| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| May 15th, 2008 | 23 | No |
Popular Name: SL-75102 SL-75102
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 3.39 | 7.6 | -50.35 | 2 | 4 | 0 | 74 | 335.762 | 6 | ↓ |
| Hi High (pH 8-9.5) | 3.39 | 9.38 | -52.73 | 1 | 4 | -1 | 77 | 334.754 | 6 | ↓ |
| Hi High (pH 8-9.5) | 3.39 | 7.37 | -46.73 | 1 | 4 | -1 | 73 | 334.754 | 6 | ↓ |
| Hi High (pH 8-9.5) | 3.39 | 9.57 | -52.16 | 1 | 4 | -1 | 77 | 334.754 | 6 | ↓ |
| Hi High (pH 8-9.5) | 3.39 | 6.99 | -51.33 | 1 | 4 | -1 | 73 | 334.754 | 6 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| GBRA1-1-E | GABA Receptor Alpha-1 Subunit (cluster #1 Of 8), Eukaryotic | Eukaryotes | 680 | 0.38 | Binding ≤ 10μM |
| GBRA2-1-E | GABA Receptor Alpha-2 Subunit (cluster #1 Of 8), Eukaryotic | Eukaryotes | 680 | 0.38 | Binding ≤ 10μM |
| GBRA3-1-E | GABA Receptor Alpha-3 Subunit (cluster #1 Of 8), Eukaryotic | Eukaryotes | 680 | 0.38 | Binding ≤ 10μM |
| GBRA4-1-E | GABA Receptor Alpha-4 Subunit (cluster #1 Of 7), Eukaryotic | Eukaryotes | 680 | 0.38 | Binding ≤ 10μM |
| GBRA5-6-E | GABA Receptor Alpha-5 Subunit (cluster #6 Of 8), Eukaryotic | Eukaryotes | 680 | 0.38 | Binding ≤ 10μM |
| GBRA6-2-E | GABA Receptor Alpha-6 Subunit (cluster #2 Of 8), Eukaryotic | Eukaryotes | 680 | 0.38 | Binding ≤ 10μM |
| GBRB1-3-E | GABA Receptor Beta-1 Subunit (cluster #3 Of 6), Eukaryotic | Eukaryotes | 680 | 0.38 | Binding ≤ 10μM |
| GBRB2-1-E | GABA Receptor Beta-2 Subunit (cluster #1 Of 7), Eukaryotic | Eukaryotes | 680 | 0.38 | Binding ≤ 10μM |
| GBRB3-1-E | GABA Receptor Beta-3 Subunit (cluster #1 Of 6), Eukaryotic | Eukaryotes | 680 | 0.38 | Binding ≤ 10μM |
| GBRD-1-E | GABA Receptor Delta Subunit (cluster #1 Of 5), Eukaryotic | Eukaryotes | 680 | 0.38 | Binding ≤ 10μM |
| GBRE-1-E | GABA Receptor Epsilon Subunit (cluster #1 Of 5), Eukaryotic | Eukaryotes | 680 | 0.38 | Binding ≤ 10μM |
| GBRG1-5-E | GABA Receptor Gamma-1 Subunit (cluster #5 Of 7), Eukaryotic | Eukaryotes | 680 | 0.38 | Binding ≤ 10μM |
| GBRG2-1-E | GABA Receptor Gamma-2 Subunit (cluster #1 Of 7), Eukaryotic | Eukaryotes | 680 | 0.38 | Binding ≤ 10μM |
| GBRG3-2-E | GABA Receptor Gamma-3 Subunit (cluster #2 Of 7), Eukaryotic | Eukaryotes | 680 | 0.38 | Binding ≤ 10μM |
| GBRP-1-E | GABA Receptor Pi Subunit (cluster #1 Of 6), Eukaryotic | Eukaryotes | 680 | 0.38 | Binding ≤ 10μM |
| GBRT-2-E | GABA Receptor Theta Subunit (cluster #2 Of 5), Eukaryotic | Eukaryotes | 680 | 0.38 | Binding ≤ 10μM |
| Z104301-4-O | GABA-A Receptor; Anion Channel (cluster #4 Of 8), Other | Other | 590 | 0.38 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| GBRA1_HUMAN | P14867 | GABA Receptor Alpha-1 Subunit, Human | 680 | 0.38 | Binding ≤ 1μM |
| GBRA2_HUMAN | P47869 | GABA Receptor Alpha-2 Subunit, Human | 680 | 0.38 | Binding ≤ 1μM |
| GBRA3_HUMAN | P34903 | GABA Receptor Alpha-3 Subunit, Human | 680 | 0.38 | Binding ≤ 1μM |
| GBRA4_HUMAN | P48169 | GABA Receptor Alpha-4 Subunit, Human | 680 | 0.38 | Binding ≤ 1μM |
| GBRA5_HUMAN | P31644 | GABA Receptor Alpha-5 Subunit, Human | 680 | 0.38 | Binding ≤ 1μM |
| GBRA6_HUMAN | Q16445 | GABA Receptor Alpha-6 Subunit, Human | 680 | 0.38 | Binding ≤ 1μM |
| GBRB1_HUMAN | P18505 | GABA Receptor Beta-1 Subunit, Human | 680 | 0.38 | Binding ≤ 1μM |
| GBRB2_HUMAN | P47870 | GABA Receptor Beta-2 Subunit, Human | 680 | 0.38 | Binding ≤ 1μM |
| GBRB3_HUMAN | P28472 | GABA Receptor Beta-3 Subunit, Human | 680 | 0.38 | Binding ≤ 1μM |
| GBRD_HUMAN | O14764 | GABA Receptor Delta Subunit, Human | 680 | 0.38 | Binding ≤ 1μM |
| GBRE_HUMAN | P78334 | GABA Receptor Epsilon Subunit, Human | 680 | 0.38 | Binding ≤ 1μM |
| GBRG1_HUMAN | Q8N1C3 | GABA Receptor Gamma-1 Subunit, Human | 680 | 0.38 | Binding ≤ 1μM |
| GBRG2_HUMAN | P18507 | GABA Receptor Gamma-2 Subunit, Human | 680 | 0.38 | Binding ≤ 1μM |
| GBRG3_HUMAN | Q99928 | GABA Receptor Gamma-3 Subunit, Human | 680 | 0.38 | Binding ≤ 1μM |
| GBRP_HUMAN | O00591 | GABA Receptor Pi Subunit, Human | 680 | 0.38 | Binding ≤ 1μM |
| GBRT_HUMAN | Q9UN88 | GABA Receptor Theta Subunit, Human | 680 | 0.38 | Binding ≤ 1μM |
| Z104301 | Z104301 | GABA-A Receptor; Anion Channel | 590 | 0.38 | Binding ≤ 1μM |
| GBRA1_HUMAN | P14867 | GABA Receptor Alpha-1 Subunit, Human | 680 | 0.38 | Binding ≤ 10μM |
| GBRA2_HUMAN | P47869 | GABA Receptor Alpha-2 Subunit, Human | 680 | 0.38 | Binding ≤ 10μM |
| GBRA3_HUMAN | P34903 | GABA Receptor Alpha-3 Subunit, Human | 680 | 0.38 | Binding ≤ 10μM |
| GBRA4_HUMAN | P48169 | GABA Receptor Alpha-4 Subunit, Human | 680 | 0.38 | Binding ≤ 10μM |
| GBRA5_HUMAN | P31644 | GABA Receptor Alpha-5 Subunit, Human | 680 | 0.38 | Binding ≤ 10μM |
| GBRA6_HUMAN | Q16445 | GABA Receptor Alpha-6 Subunit, Human | 680 | 0.38 | Binding ≤ 10μM |
| GBRB1_HUMAN | P18505 | GABA Receptor Beta-1 Subunit, Human | 680 | 0.38 | Binding ≤ 10μM |
| GBRB2_HUMAN | P47870 | GABA Receptor Beta-2 Subunit, Human | 680 | 0.38 | Binding ≤ 10μM |
| GBRB3_HUMAN | P28472 | GABA Receptor Beta-3 Subunit, Human | 680 | 0.38 | Binding ≤ 10μM |
| GBRD_HUMAN | O14764 | GABA Receptor Delta Subunit, Human | 680 | 0.38 | Binding ≤ 10μM |
| GBRE_HUMAN | P78334 | GABA Receptor Epsilon Subunit, Human | 680 | 0.38 | Binding ≤ 10μM |
| GBRG1_HUMAN | Q8N1C3 | GABA Receptor Gamma-1 Subunit, Human | 680 | 0.38 | Binding ≤ 10μM |
| GBRG2_HUMAN | P18507 | GABA Receptor Gamma-2 Subunit, Human | 680 | 0.38 | Binding ≤ 10μM |
| GBRG3_HUMAN | Q99928 | GABA Receptor Gamma-3 Subunit, Human | 680 | 0.38 | Binding ≤ 10μM |
| GBRP_HUMAN | O00591 | GABA Receptor Pi Subunit, Human | 680 | 0.38 | Binding ≤ 10μM |
| GBRT_HUMAN | Q9UN88 | GABA Receptor Theta Subunit, Human | 680 | 0.38 | Binding ≤ 10μM |
| Z104301 | Z104301 | GABA-A Receptor; Anion Channel | 590 | 0.38 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| GABA A receptor activation | |
| Ligand-gated ion channel transport |
No pre-computed analogs available. Try a structural similarity search.