| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| July 25th, 2004 | 29 | Yes |
Popular Name: Colchicine Colchicine
Find On: PubMed — Wikipedia — Google
CAS Numbers: 54192-66-4 , 64-86-8 , [64-86-8]
(S)-N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide
64-86-8; Colchicine (JP16/USP); Colchicine (TN); D00570
64-86-8; Colchicine; Prestwick_695
Acetamide, N-((7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)-
Acetamide, N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(.alpha.)heptalen-7-yl)-
Acetamide, N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)-, (S)-
Acetamide, N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(alpha)heptalen-7-yl)-
Acetamide, N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[.alpha.]heptalen-7-yl)-
Acetamide, N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)-, (S)-
Benzo(a)heptalen-9(5H)-one, 7-acetamido-6,7-dihydro-1,2,3,10-tetramethoxy-
Benzo[a]heptalen-9(5H)-one, 7-acetamido-6,7-dihydro-1,2,3,10-tetramethoxy-
Colchicin;Colchicina;Colchicinum
Colchicine (contains 5% Ethyl Acetate at maximum)
Colchicine, 95% (dry wt.), may cont. up to 2% water and 8% ethyl acetate
Colchicine, Colchicum autumnale
COLCHICINE; LS-187917; PROBENECID; PROBENECID AND COLCHICINE
CPD-9785; colchicin; colchicina; colchicine; colsaloid; condylon; spindle poison
inhibits microtubular assembly
N-((7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)- acetamide
N-((S)-1,2,3,10-Tetramethoxy-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalen-7-yl)-acetamide
N-(1,2,3,10-Tetramethoxy-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalen-7-yl)-acetamide
N-(1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl)acetamide
N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)acetamide
N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[.alpha.]heptalen-7-yl)-acetamide
N-Acetyl trimethylcolchicinic acid methylether
N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl]acetamide
N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide
N-[(7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]acetamide
N1-(1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl)acetamide
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 1.10 | 7.99 | -20.74 | 1 | 7 | 0 | 83 | 399.443 | 5 | ↓ |
| Note Type | Comments | Provided By |
|---|---|---|
| biological_source | Chief alkaloid from Colchicum autumnale, many other Colchicum spp., several Merendera spp., Gloriosa superba and others (Liliaceae) | ZereneX Building Blocks |
| Molecular_Solubility | 4.695 | Bitter DB |
| mechanism | . | ZereneX Building Blocks |
| Mp [°C] | 150 - 160 | Acros Organics |
| M.P | 150-160 °C | Indofine Natural Products |
| MP | 150-160 °C (dec.)(lit.) | Indofine |
| MP | 155 - 157 | Enamine Building Blocks |
| MP | 155...157 | Enamine Building Blocks |
| M.P | 157C | Indofine Natural Products |
| ALOGPS_SOLUBILITY | 2.76e-02 g/l | DrugBank-approved |
| purity | 9.500000000000000e+001 | Enamine Building Blocks Enamine Building Blocks |
| Therapy | antimitotic, antigout agent | SMDC Iconix |
| biological_use | Antirheumatic | IBScreen Bioactives |
| Melting_Point | ca 150? dec. | Alfa-Aesar |
| Melting_Point | ca 150° dec. | Alfa-Aesar |
| biological_use | Cytostatic | IBScreen Bioactives |
| Patent Database Links | EP0970694; EP0984012; EP1104760; EP1229034; EP1438962; EP1516597; EP1574499; EP1669091; EP1698635; EP1757250; EP1780268; EP1788085; EP1808172; EP1813623; EP1870105; EP1889847; EP1947113; EP1967189; EP1982720; US2002037918; US2004097503; US2004132722; US20 | ChEBI |
| Patent Database Links | EP0970694; EP0984012; EP1104760; EP1229034; EP1438962; EP1516597; EP1574499; EP1669091; EP1698635; EP1757250; EP1780268; EP1808172; EP1813623; EP1870105; EP1889847; EP1947113; EP1967189; EP1982720; US2002037918; US2004097503; US2004132722; US2004171637; U | ChEBI |
| mechanism | Exact mechanism unknown | IBScreen Bioactives |
| UniProt Database Links | GENL2_ORYSJ; MEFV_HUMAN | ChEBI |
| SOLUBILITY | H2O: 10 mg/mL | Indofine Natural Products |
| H phrase | H300: Fatal if swallowed | Acros Organics |
| H phrase | H300: Fatal if swallowed; H340: May cause genetic defects | Acros Organics |
| biological_use | Immunosuppressive | IBScreen Bioactives IBScreen Bioactives |
| mechanism | Interferes with kinin formation | IBScreen Bioactives |
| mechanism | Leukocyte migration inhibitor | IBScreen Bioactives IBScreen Bioactives |
| P phrase | P301 + P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician | Acros Organics |
| P phrase | P301 + P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician; P201: Obtain special instructions before use; P308 + P313: IF exposed or concerned: Get medical advice/attention | Acros Organics |
| mechanism | Phagocytosis inhibitor | IBScreen Bioactives |
| biological_use | Potential HIV inhibitor | IBScreen Bioactives |
| Target | Prostaglandin E synthase(O14684)&Glucose-6-phosphate 1-dehydrogenase(P11413)&Aldehyde dehydrogenase, dimeric NADP-preferring(P30838)&Peroxisome proliferator-activated receptor gamma(P37231)&Transcription factor p65(Q04206)&Cytosolic phospholipase A2(P4771 | Herbal Ingredients Targets |
| R phrase | R46: May cause heritable genetic damage. | Acros Organics |
| R phrase | R46: May cause heritable genetic damage.; R28: Very toxic if swallowed. | Acros Organics |
| Reactome Database Links | REACT_15538; REACT_163726; REACT_22239; REACT_22289 | ChEBI |
| mechanism | Reduces phagocytosis with inflammatory | IBScreen Bioactives |
| mechanism | Response abatement | IBScreen Bioactives |
| SOLUBILITY | Soluble in chloroform | Indofine Natural Products |
| Hazard | T+: Very toxic | Acros Organics |
| APPEARANCE | White to yellow with a green cast | Indofine Natural Products |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| Q862F3-2-E | Tubulin Alpha Chain (cluster #2 Of 2), Eukaryotic | Eukaryotes | 2500 | 0.27 | Binding ≤ 10μM |
| Q862L2-2-E | Tubulin Alpha-1 Chain (cluster #2 Of 2), Eukaryotic | Eukaryotes | 2500 | 0.27 | Binding ≤ 10μM |
| TBA1A-1-E | Tubulin Alpha-3 Chain (cluster #1 Of 3), Eukaryotic | Eukaryotes | 5750 | 0.25 | Binding ≤ 10μM |
| TBA4A-1-E | Tubulin Alpha-1 Chain (cluster #1 Of 1), Eukaryotic | Eukaryotes | 2700 | 0.27 | Binding ≤ 10μM |
| TBB-1-E | Tubulin Beta Chain (cluster #1 Of 1), Eukaryotic | Eukaryotes | 1260 | 0.28 | Binding ≤ 10μM |
| TBB1-1-E | Tubulin Beta-1 Chain (cluster #1 Of 2), Eukaryotic | Eukaryotes | 800 | 0.29 | Binding ≤ 10μM |
| TBB2B-1-E | Tubulin Beta Chain (cluster #1 Of 1), Eukaryotic | Eukaryotes | 780 | 0.29 | Binding ≤ 10μM |
| TBB3-1-E | Tubulin Beta-3 Chain (cluster #1 Of 1), Eukaryotic | Eukaryotes | 5750 | 0.25 | Binding ≤ 10μM |
| TBB4A-1-E | Tubulin Beta-4 Chain (cluster #1 Of 1), Eukaryotic | Eukaryotes | 500 | 0.30 | Binding ≤ 10μM |
| TBB4B-1-E | Tubulin Beta-2 Chain (cluster #1 Of 1), Eukaryotic | Eukaryotes | 500 | 0.30 | Binding ≤ 10μM |
| TBB5-1-E | Tubulin Beta-5 Chain (cluster #1 Of 1), Eukaryotic | Eukaryotes | 5750 | 0.25 | Binding ≤ 10μM |
| TBB8-1-E | Tubulin Beta-8 Chain (cluster #1 Of 1), Eukaryotic | Eukaryotes | 500 | 0.30 | Binding ≤ 10μM |
| TBG1-1-E | Tubulin Gamma-1 Chain (cluster #1 Of 1), Eukaryotic | Eukaryotes | 5750 | 0.25 | Binding ≤ 10μM |
| Q862F3-1-E | Tubulin Alpha Chain (cluster #1 Of 2), Eukaryotic | Eukaryotes | 8700 | 0.24 | Functional ≤ 10μM |
| Q862L2-1-E | Tubulin Alpha-1 Chain (cluster #1 Of 2), Eukaryotic | Eukaryotes | 8700 | 0.24 | Functional ≤ 10μM |
| TBA1A-1-E | Tubulin Alpha-1 Chain (cluster #1 Of 2), Eukaryotic | Eukaryotes | 800 | 0.29 | Functional ≤ 10μM |
| TBA4A-1-E | Tubulin Alpha-1 Chain (cluster #1 Of 1), Eukaryotic | Eukaryotes | 1700 | 0.28 | Functional ≤ 10μM |
| TBB1-1-E | Tubulin Beta-1 Chain (cluster #1 Of 2), Eukaryotic | Eukaryotes | 800 | 0.29 | Functional ≤ 10μM |
| TBB2B-1-E | Tubulin Beta Chain (cluster #1 Of 2), Eukaryotic | Eukaryotes | 8700 | 0.24 | Functional ≤ 10μM |
| TBB3-1-E | Tubulin Beta-3 Chain (cluster #1 Of 3), Eukaryotic | Eukaryotes | 4200 | 0.26 | Functional ≤ 10μM |
| TBB4A-1-E | Tubulin Beta-4 Chain (cluster #1 Of 3), Eukaryotic | Eukaryotes | 4200 | 0.26 | Functional ≤ 10μM |
| TBB4B-1-E | Tubulin Beta-2 Chain (cluster #1 Of 3), Eukaryotic | Eukaryotes | 4200 | 0.26 | Functional ≤ 10μM |
| TBB5-1-E | Tubulin Beta-5 Chain (cluster #1 Of 1), Eukaryotic | Eukaryotes | 3300 | 0.26 | Functional ≤ 10μM |
| TBB8-1-E | Tubulin Beta-8 Chain (cluster #1 Of 3), Eukaryotic | Eukaryotes | 4200 | 0.26 | Functional ≤ 10μM |
| Z101682-1-O | BK Polyomavirus (cluster #1 Of 2), Other | Other | 22 | 0.37 | Functional ≤ 10μM |
| Z103203-1-O | A375 (cluster #1 Of 3), Other | Other | 20 | 0.37 | Functional ≤ 10μM |
| Z103205-1-O | A431 (cluster #1 Of 4), Other | Other | 53 | 0.35 | Functional ≤ 10μM |
| Z50425-3-O | Plasmodium Falciparum (cluster #3 Of 22), Other | Other | 10000 | 0.24 | Functional ≤ 10μM |
| Z50590-1-O | Sus Scrofa (cluster #1 Of 1), Other | Other | 1400 | 0.28 | Functional ≤ 10μM |
| Z50607-1-O | Human Immunodeficiency Virus 1 (cluster #1 Of 10), Other | Other | 18 | 0.37 | Functional ≤ 10μM |
| Z80002-1-O | 1A9 (Ovarian Adenocarcinoma Cells) (cluster #1 Of 2), Other | Other | 12 | 0.38 | Functional ≤ 10μM |
| Z80024-1-O | A9 (Fibroblast Cells) (cluster #1 Of 3), Other | Other | 14 | 0.38 | Functional ≤ 10μM |
| Z80025-1-O | ACHN (Renal Adenocarcinoma Cells) (cluster #1 Of 3), Other | Other | 40 | 0.36 | Functional ≤ 10μM |
| Z80035-1-O | B16 (Melanoma Cells) (cluster #1 Of 7), Other | Other | 31 | 0.36 | Functional ≤ 10μM |
| Z80088-1-O | CHO (Ovarian Cells) (cluster #1 Of 4), Other | Other | 220 | 0.32 | Functional ≤ 10μM |
| Z80096-1-O | CHO-TAX 5-6 (cluster #1 Of 2), Other | Other | 140 | 0.33 | Functional ≤ 10μM |
| Z80097-1-O | CHO-VV 3-2 (cluster #1 Of 2), Other | Other | 620 | 0.30 | Functional ≤ 10μM |
| Z80120-1-O | DLD-1 (Colon Adenocarcinoma Cells) (cluster #1 Of 5), Other | Other | 190 | 0.32 | Functional ≤ 10μM |
| Z80125-1-O | DU-145 (Prostate Carcinoma) (cluster #1 Of 9), Other | Other | 10 | 0.39 | Functional ≤ 10μM |
| Z80156-1-O | HL-60 (Promyeloblast Leukemia Cells) (cluster #1 Of 12), Other | Other | 53 | 0.35 | Functional ≤ 10μM |
| Z80164-1-O | HT-1080 (Fibrosarcoma Cells) (cluster #1 Of 6), Other | Other | 1 | 0.43 | Functional ≤ 10μM |
| Z80166-1-O | HT-29 (Colon Adenocarcinoma Cells) (cluster #1 Of 12), Other | Other | 22 | 0.37 | Functional ≤ 10μM |
| Z80186-1-O | K562 (Erythroleukemia Cells) (cluster #1 Of 11), Other | Other | 7 | 0.39 | Functional ≤ 10μM |
| Z80193-2-O | L1210 (Lymphocytic Leukemia Cells) (cluster #2 Of 12), Other | Other | 7 | 0.39 | Functional ≤ 10μM |
| Z80211-1-O | LoVo (Colon Adenocarcinoma Cells) (cluster #1 Of 5), Other | Other | 6 | 0.40 | Functional ≤ 10μM |
| Z80224-1-O | MCF7 (Breast Carcinoma Cells) (cluster #1 Of 14), Other | Other | 1900 | 0.28 | Functional ≤ 10μM |
| Z80244-4-O | MDA-MB-468 (Breast Adenocarcinoma) (cluster #4 Of 7), Other | Other | 7 | 0.39 | Functional ≤ 10μM |
| Z80269-1-O | MKN-45 (Gastric Adenocarcinoma Cells) (cluster #1 Of 3), Other | Other | 15 | 0.38 | Functional ≤ 10μM |
| Z80354-1-O | OVCAR-3 (Ovarian Adenocarcinoma Cells) (cluster #1 Of 4), Other | Other | 800 | 0.29 | Functional ≤ 10μM |
| Z80362-1-O | P388 (Lymphoma Cells) (cluster #1 Of 8), Other | Other | 10 | 0.39 | Functional ≤ 10μM |
| Z80390-1-O | PC-3 (Prostate Carcinoma Cells) (cluster #1 Of 10), Other | Other | 33 | 0.36 | Functional ≤ 10μM |
| Z80414-1-O | Raji (B-lymphoblastic Cells) (cluster #1 Of 3), Other | Other | 14 | 0.38 | Functional ≤ 10μM |
| Z80427-1-O | RKO (Colon Carcinoma) (cluster #1 Of 1), Other | Other | 20 | 0.37 | Functional ≤ 10μM |
| Z80466-1-O | SF268 (cluster #1 Of 4), Other | Other | 50 | 0.35 | Functional ≤ 10μM |
| Z80475-1-O | SK-BR-3 (Breast Adenocarcinoma) (cluster #1 Of 3), Other | Other | 5 | 0.40 | Functional ≤ 10μM |
| Z80493-2-O | SK-OV-3 (Ovarian Carcinoma Cells) (cluster #2 Of 6), Other | Other | 71 | 0.35 | Functional ≤ 10μM |
| Z80526-1-O | SW480 (Colon Adenocarcinoma Cells) (cluster #1 Of 6), Other | Other | 30 | 0.36 | Functional ≤ 10μM |
| Z80566-1-O | U-937 (Histiocytic Lymphoma Cells) (cluster #1 Of 2), Other | Other | 5 | 0.40 | Functional ≤ 10μM |
| Z80583-1-O | Vero (Kidney Cells) (cluster #1 Of 7), Other | Other | 390 | 0.31 | Functional ≤ 10μM |
| Z80608-1-O | ZR-75-1 (Breast Carcinoma Cells) (cluster #1 Of 4), Other | Other | 6 | 0.40 | Functional ≤ 10μM |
| Z80682-1-O | A549 (Lung Carcinoma Cells) (cluster #1 Of 11), Other | Other | 45 | 0.35 | Functional ≤ 10μM |
| Z80711-1-O | NCI/ADR-RES (Breast Carcinoma Cells) (cluster #1 Of 2), Other | Other | 1113 | 0.29 | Functional ≤ 10μM |
| Z80712-2-O | T47D (Breast Carcinoma Cells) (cluster #2 Of 7), Other | Other | 9 | 0.39 | Functional ≤ 10μM |
| Z80720-1-O | Burkitts Lymphoma Cells (cluster #1 Of 1), Other | Other | 50 | 0.35 | Functional ≤ 10μM |
| Z80819-1-O | J774.2 (cluster #1 Of 1), Other | Other | 52 | 0.35 | Functional ≤ 10μM |
| Z80852-1-O | A-431 (Epidermoid Carcinoma Cells) (cluster #1 Of 3), Other | Other | 3 | 0.41 | Functional ≤ 10μM |
| Z80874-1-O | CEM (T-cell Leukemia) (cluster #1 Of 7), Other | Other | 8 | 0.39 | Functional ≤ 10μM |
| Z80928-3-O | HCT-116 (Colon Carcinoma Cells) (cluster #3 Of 9), Other | Other | 40 | 0.36 | Functional ≤ 10μM |
| Z81020-3-O | HepG2 (Hepatoblastoma Cells) (cluster #3 Of 8), Other | Other | 50 | 0.35 | Functional ≤ 10μM |
| Z81024-1-O | NCI-H460 (Non-small Cell Lung Carcinoma) (cluster #1 Of 8), Other | Other | 70 | 0.35 | Functional ≤ 10μM |
| Z81054-2-O | SF-268 (Glioblastoma Cells) (cluster #2 Of 3), Other | Other | 50 | 0.35 | Functional ≤ 10μM |
| Z81072-1-O | Jurkat (Acute Leukemic T-cells) (cluster #1 Of 10), Other | Other | 17 | 0.38 | Functional ≤ 10μM |
| Z81115-1-O | KB (Squamous Cell Carcinoma) (cluster #1 Of 6), Other | Other | 6 | 0.40 | Functional ≤ 10μM |
| Z81170-1-O | LNCaP (Prostate Carcinoma) (cluster #1 Of 5), Other | Other | 20 | 0.37 | Functional ≤ 10μM |
| Z81244-1-O | J774 (Macrophage Cells) (cluster #1 Of 1), Other | Other | 93 | 0.34 | Functional ≤ 10μM |
| Z81245-1-O | MDA-MB-435 (Breast Carcinoma Cells) (cluster #1 Of 6), Other | Other | 7 | 0.39 | Functional ≤ 10μM |
| Z81247-1-O | HeLa (Cervical Adenocarcinoma Cells) (cluster #1 Of 9), Other | Other | 39 | 0.36 | Functional ≤ 10μM |
| Z81252-3-O | MDA-MB-231 (Breast Adenocarcinoma Cells) (cluster #3 Of 11), Other | Other | 70 | 0.35 | Functional ≤ 10μM |
| Z81281-1-O | NCI-H23 (Non-small Cell Lung Carcinoma Cells) (cluster #1 Of 5), Other | Other | 13 | 0.38 | Functional ≤ 10μM |
| Z81283-1-O | NCI-H522 (Non-small Cell Lung Carcinoma Cells) (cluster #1 Of 2), Other | Other | 14 | 0.38 | Functional ≤ 10μM |
| Z81331-1-O | SW-620 (Colon Adenocarcinoma Cells) (cluster #1 Of 6), Other | Other | 14 | 0.38 | Functional ≤ 10μM |
| Z81335-2-O | HCT-15 (Colon Adenocarcinoma Cells) (cluster #2 Of 5), Other | Other | 140 | 0.33 | Functional ≤ 10μM |
| Z80583-1-O | Vero (Kidney Cells) (cluster #1 Of 3), Other | Other | 530 | 0.30 | ADME/T ≤ 10μM |
| Z80608-1-O | ZR-75-1 (Breast Carcinoma Cells) (cluster #1 Of 1), Other | Other | 522 | 0.30 | ADME/T ≤ 10μM |
| Z80897-1-O | H9 (T-lymphoid Cells) (cluster #1 Of 2), Other | Other | 10 | 0.39 | ADME/T ≤ 10μM |
| Z80928-1-O | HCT-116 (Colon Carcinoma Cells) (cluster #1 Of 2), Other | Other | 3 | 0.41 | ADME/T ≤ 10μM |
| Z81244-1-O | J774 (Macrophage Cells) (cluster #1 Of 3), Other | Other | 210 | 0.32 | ADME/T ≤ 10μM |
| Z81247-1-O | HeLa (Cervical Adenocarcinoma Cells) (cluster #1 Of 3), Other | Other | 2 | 0.42 | ADME/T ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| TBA1A_PIG | P02550 | Tubulin Alpha Chain, Pig | 800 | 0.29 | Binding ≤ 1μM |
| TBA1A_RAT | P68370 | Tubulin Alpha-1 Chain, Rat | 800 | 0.29 | Binding ≤ 1μM |
| TBB2B_BOVIN | Q6B856 | Tubulin Beta Chain, Bovin | 780 | 0.29 | Binding ≤ 1μM |
| TBB1_HUMAN | Q9H4B7 | Tubulin Beta-1 Chain, Human | 800 | 0.29 | Binding ≤ 1μM |
| TBB4B_HUMAN | P68371 | Tubulin Beta-2 Chain, Human | 500 | 0.30 | Binding ≤ 1μM |
| TBB3_HUMAN | Q13509 | Tubulin Beta-3 Chain, Human | 500 | 0.30 | Binding ≤ 1μM |
| TBB4A_HUMAN | P04350 | Tubulin Beta-4 Chain, Human | 500 | 0.30 | Binding ≤ 1μM |
| TBB5_HUMAN | P07437 | Tubulin Beta-5 Chain, Human | 500 | 0.30 | Binding ≤ 1μM |
| TBB8_HUMAN | Q3ZCM7 | Tubulin Beta-8 Chain, Human | 500 | 0.30 | Binding ≤ 1μM |
| Q862F3_BOVIN | Q862F3 | Tubulin Alpha Chain, Bovin | 1900 | 0.28 | Binding ≤ 10μM |
| TBA1A_PIG | P02550 | Tubulin Alpha Chain, Pig | 10000 | 0.24 | Binding ≤ 10μM |
| TBA1A_RAT | P68370 | Tubulin Alpha-1 Chain, Rat | 800 | 0.29 | Binding ≤ 10μM |
| Q862L2_BOVIN | Q862L2 | Tubulin Alpha-1 Chain, Bovin | 1900 | 0.28 | Binding ≤ 10μM |
| TBA4A_HUMAN | P68366 | Tubulin Alpha-1 Chain, Human | 2700 | 0.27 | Binding ≤ 10μM |
| TBA1A_HUMAN | Q71U36 | Tubulin Alpha-3 Chain, Human | 5750 | 0.25 | Binding ≤ 10μM |
| TBB2B_BOVIN | Q6B856 | Tubulin Beta Chain, Bovin | 1250 | 0.28 | Binding ≤ 10μM |
| TBB_PIG | P02554 | Tubulin Beta Chain, Pig | 10000 | 0.24 | Binding ≤ 10μM |
| TBB2B_RAT | Q3KRE8 | Tubulin Beta Chain, Rat | 5750 | 0.25 | Binding ≤ 10μM |
| TBB1_HUMAN | Q9H4B7 | Tubulin Beta-1 Chain, Human | 1400 | 0.28 | Binding ≤ 10μM |
| TBB4B_HUMAN | P68371 | Tubulin Beta-2 Chain, Human | 1400 | 0.28 | Binding ≤ 10μM |
| TBB3_RAT | Q4QRB4 | Tubulin Beta-3 Chain, Rat | 5750 | 0.25 | Binding ≤ 10μM |
| TBB3_HUMAN | Q13509 | Tubulin Beta-3 Chain, Human | 1400 | 0.28 | Binding ≤ 10μM |
| TBB4A_HUMAN | P04350 | Tubulin Beta-4 Chain, Human | 1400 | 0.28 | Binding ≤ 10μM |
| TBB5_HUMAN | P07437 | Tubulin Beta-5 Chain, Human | 500 | 0.30 | Binding ≤ 10μM |
| TBB8_HUMAN | Q3ZCM7 | Tubulin Beta-8 Chain, Human | 1400 | 0.28 | Binding ≤ 10μM |
| TBG1_RAT | P83888 | Tubulin Gamma-1 Chain, Rat | 5750 | 0.25 | Binding ≤ 10μM |
| Z80002 | Z80002 | 1A9 (Ovarian Adenocarcinoma Cells) | 11.9 | 0.38 | Functional ≤ 10μM |
| Z80852 | Z80852 | A-431 (Epidermoid Carcinoma Cells) | 14 | 0.38 | Functional ≤ 10μM |
| Z103203 | Z103203 | A375 | 20 | 0.37 | Functional ≤ 10μM |
| Z103205 | Z103205 | A431 | 53.2 | 0.35 | Functional ≤ 10μM |
| Z80682 | Z80682 | A549 (Lung Carcinoma Cells) | 1000 | 0.29 | Functional ≤ 10μM |
| Z80024 | Z80024 | A9 (Fibroblast Cells) | 13.8 | 0.38 | Functional ≤ 10μM |
| Z80025 | Z80025 | ACHN (Renal Adenocarcinoma Cells) | 39.8 | 0.36 | Functional ≤ 10μM |
| Z80035 | Z80035 | B16 (Melanoma Cells) | 31 | 0.36 | Functional ≤ 10μM |
| Z101682 | Z101682 | BK Polyomavirus | 22 | 0.37 | Functional ≤ 10μM |
| Z80720 | Z80720 | Burkitts Lymphoma Cells | 50 | 0.35 | Functional ≤ 10μM |
| Z80874 | Z80874 | CEM (T-cell Leukemia) | 17.2 | 0.37 | Functional ≤ 10μM |
| Z80088 | Z80088 | CHO (Ovarian Cells) | 220 | 0.32 | Functional ≤ 10μM |
| Z80096 | Z80096 | CHO-TAX 5-6 | 140 | 0.33 | Functional ≤ 10μM |
| Z80097 | Z80097 | CHO-VV 3-2 | 620 | 0.30 | Functional ≤ 10μM |
| Z80120 | Z80120 | DLD-1 (Colon Adenocarcinoma Cells) | 190 | 0.32 | Functional ≤ 10μM |
| Z80125 | Z80125 | DU-145 (Prostate Carcinoma) | 10 | 0.39 | Functional ≤ 10μM |
| Z80928 | Z80928 | HCT-116 (Colon Carcinoma Cells) | 15 | 0.38 | Functional ≤ 10μM |
| Z81335 | Z81335 | HCT-15 (Colon Adenocarcinoma Cells) | 100 | 0.34 | Functional ≤ 10μM |
| Z81247 | Z81247 | HeLa (Cervical Adenocarcinoma Cells) | 1000 | 0.29 | Functional ≤ 10μM |
| Z81020 | Z81020 | HepG2 (Hepatoblastoma Cells) | 1900 | 0.28 | Functional ≤ 10μM |
| Z80156 | Z80156 | HL-60 (Promyeloblast Leukemia Cells) | 53 | 0.35 | Functional ≤ 10μM |
| Z80164 | Z80164 | HT-1080 (Fibrosarcoma Cells) | 1.1 | 0.43 | Functional ≤ 10μM |
| Z80166 | Z80166 | HT-29 (Colon Adenocarcinoma Cells) | 10 | 0.39 | Functional ≤ 10μM |
| Z50607 | Z50607 | Human Immunodeficiency Virus 1 | 18 | 0.37 | Functional ≤ 10μM |
| Z81244 | Z81244 | J774 (Macrophage Cells) | 93.1 | 0.34 | Functional ≤ 10μM |
| Z80819 | Z80819 | J774.2 | 228.3 | 0.32 | Functional ≤ 10μM |
| Z81072 | Z81072 | Jurkat (Acute Leukemic T-cells) | 17 | 0.38 | Functional ≤ 10μM |
| Z80186 | Z80186 | K562 (Erythroleukemia Cells) | 14.1 | 0.38 | Functional ≤ 10μM |
| Z81115 | Z81115 | KB (Squamous Cell Carcinoma) | 10 | 0.39 | Functional ≤ 10μM |
| Z80193 | Z80193 | L1210 (Lymphocytic Leukemia Cells) | 14.7 | 0.38 | Functional ≤ 10μM |
| Z81170 | Z81170 | LNCaP (Prostate Carcinoma) | 16 | 0.38 | Functional ≤ 10μM |
| Z80211 | Z80211 | LoVo (Colon Adenocarcinoma Cells) | 101 | 0.34 | Functional ≤ 10μM |
| Z80224 | Z80224 | MCF7 (Breast Carcinoma Cells) | 12 | 0.38 | Functional ≤ 10μM |
| Z81252 | Z81252 | MDA-MB-231 (Breast Adenocarcinoma Cells) | 1.8 | 0.42 | Functional ≤ 10μM |
| Z81245 | Z81245 | MDA-MB-435 (Breast Carcinoma Cells) | 2000 | 0.28 | Functional ≤ 10μM |
| Z80244 | Z80244 | MDA-MB-468 (Breast Adenocarcinoma) | 6.9 | 0.39 | Functional ≤ 10μM |
| Z80269 | Z80269 | MKN-45 (Gastric Adenocarcinoma Cells) | 15 | 0.38 | Functional ≤ 10μM |
| Z81281 | Z81281 | NCI-H23 (Non-small Cell Lung Carcinoma Cells) | 13 | 0.38 | Functional ≤ 10μM |
| Z81024 | Z81024 | NCI-H460 (Non-small Cell Lung Carcinoma) | 10 | 0.39 | Functional ≤ 10μM |
| Z81283 | Z81283 | NCI-H522 (Non-small Cell Lung Carcinoma Cells) | 14 | 0.38 | Functional ≤ 10μM |
| Z80711 | Z80711 | NCI/ADR-RES (Breast Carcinoma Cells) | 1113 | 0.29 | Functional ≤ 10μM |
| Z80354 | Z80354 | OVCAR-3 (Ovarian Adenocarcinoma Cells) | 800 | 0.29 | Functional ≤ 10μM |
| Z80362 | Z80362 | P388 (Lymphoma Cells) | 0.62 | 0.44 | Functional ≤ 10μM |
| Z80390 | Z80390 | PC-3 (Prostate Carcinoma Cells) | 10 | 0.39 | Functional ≤ 10μM |
| Z50425 | Z50425 | Plasmodium Falciparum | 10000 | 0.24 | Functional ≤ 10μM |
| Z80414 | Z80414 | Raji (B-lymphoblastic Cells) | 14 | 0.38 | Functional ≤ 10μM |
| Z80427 | Z80427 | RKO (Colon Carcinoma) | 10 | 0.39 | Functional ≤ 10μM |
| Z81054 | Z81054 | SF-268 (Glioblastoma Cells) | 25 | 0.37 | Functional ≤ 10μM |
| Z80466 | Z80466 | SF268 | 10 | 0.39 | Functional ≤ 10μM |
| Z80475 | Z80475 | SK-BR-3 (Breast Adenocarcinoma) | 5 | 0.40 | Functional ≤ 10μM |
| Z80493 | Z80493 | SK-OV-3 (Ovarian Carcinoma Cells) | 10 | 0.39 | Functional ≤ 10μM |
| Z50590 | Z50590 | Sus Scrofa | 1400 | 0.28 | Functional ≤ 10μM |
| Z81331 | Z81331 | SW-620 (Colon Adenocarcinoma Cells) | 14 | 0.38 | Functional ≤ 10μM |
| Z80526 | Z80526 | SW480 (Colon Adenocarcinoma Cells) | 30 | 0.36 | Functional ≤ 10μM |
| Z80712 | Z80712 | T47D (Breast Carcinoma Cells) | 14 | 0.38 | Functional ≤ 10μM |
| TBA1A_PIG | P02550 | Tubulin Alpha Chain, Pig | 1500 | 0.28 | Functional ≤ 10μM |
| Q862F3_BOVIN | Q862F3 | Tubulin Alpha Chain, Bovin | 1700 | 0.28 | Functional ≤ 10μM |
| Q862L2_BOVIN | Q862L2 | Tubulin Alpha-1 Chain, Bovin | 1700 | 0.28 | Functional ≤ 10μM |
| TBA1A_RAT | P68370 | Tubulin Alpha-1 Chain, Rat | 1400 | 0.28 | Functional ≤ 10μM |
| TBA4A_HUMAN | P68366 | Tubulin Alpha-1 Chain, Human | 1700 | 0.28 | Functional ≤ 10μM |
| TBB2B_BOVIN | Q6B856 | Tubulin Beta Chain, Bovin | 1700 | 0.28 | Functional ≤ 10μM |
| TBB1_HUMAN | Q9H4B7 | Tubulin Beta-1 Chain, Human | 1400 | 0.28 | Functional ≤ 10μM |
| TBB4B_HUMAN | P68371 | Tubulin Beta-2 Chain, Human | 1500 | 0.28 | Functional ≤ 10μM |
| TBB3_HUMAN | Q13509 | Tubulin Beta-3 Chain, Human | 1500 | 0.28 | Functional ≤ 10μM |
| TBB4A_HUMAN | P04350 | Tubulin Beta-4 Chain, Human | 1500 | 0.28 | Functional ≤ 10μM |
| TBB5_HUMAN | P07437 | Tubulin Beta-5 Chain, Human | 3200 | 0.27 | Functional ≤ 10μM |
| TBB8_HUMAN | Q3ZCM7 | Tubulin Beta-8 Chain, Human | 1500 | 0.28 | Functional ≤ 10μM |
| Z80566 | Z80566 | U-937 (Histiocytic Lymphoma Cells) | 5.2 | 0.40 | Functional ≤ 10μM |
| Z80583 | Z80583 | Vero (Kidney Cells) | 270 | 0.32 | Functional ≤ 10μM |
| Z80608 | Z80608 | ZR-75-1 (Breast Carcinoma Cells) | 6 | 0.40 | Functional ≤ 10μM |
| Z80897 | Z80897 | H9 (T-lymphoid Cells) | 10 | 0.39 | ADME/T ≤ 10μM |
| Z80928 | Z80928 | HCT-116 (Colon Carcinoma Cells) | 2.75 | 0.41 | ADME/T ≤ 10μM |
| Z81247 | Z81247 | HeLa (Cervical Adenocarcinoma Cells) | 1.84 | 0.42 | ADME/T ≤ 10μM |
| Z81244 | Z81244 | J774 (Macrophage Cells) | 210 | 0.32 | ADME/T ≤ 10μM |
| Z80583 | Z80583 | Vero (Kidney Cells) | 530 | 0.30 | ADME/T ≤ 10μM |
| Z80608 | Z80608 | ZR-75-1 (Breast Carcinoma Cells) | 522 | 0.30 | ADME/T ≤ 10μM |
| Description | Species |
|---|---|
| Class C/3 (Metabotropic glutamate/pheromone receptors) | |
| G alpha (i) signalling events |
| Description | Species |
|---|---|
| Formation of tubulin folding intermediates by CCT/TriC | |
| Gap junction assembly | |
| Kinesins | |
| Loss of Nlp from mitotic centrosomes | |
| Loss of proteins required for interphase microtubule organization from the ce | |
| MHC class II antigen presentation | |
| Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | |
| Mitotic Prometaphase | |
| Platelet degranulation | |
| Post-chaperonin tubulin folding pathway | |
| Prefoldin mediated transfer of substrate to CCT/TriC | |
| Recruitment of mitotic centrosome proteins and complexes | |
| Recruitment of NuMA to mitotic centrosomes | |
| Recycling pathway of L1 | |
| Regulation of PLK1 Activity at G2/M Transition | |
| Resolution of Sister Chromatid Cohesion | |
| Separation of Sister Chromatids | |
| Translocation of GLUT4 to the plasma membrane |
