In ZINC since | Heavy atoms | Benign functionality |
---|---|---|
June 19th, 2008 | 23 | Yes |
Popular Name: Combretastatin A4 Combretastatin A4
Find On: PubMed — Wikipedia — Google
CAS Numbers: 117048-59-6 , [117048-59-6]
"(Z)-2-Methoxy-5-(3,4,5-trimethoxystyryl)phenol, 98%"
117048-59-6; C20268; Combretastatin A-4; Combretastatin A4
2-Methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenol
Phenol, 2-methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]-
Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
---|---|---|---|---|---|---|---|---|---|---|
Ref Reference (pH 7) | 3.47 | 5.32 | -10.67 | 1 | 5 | 0 | 57 | 316.353 | 6 | ↓ |
Note Type | Comments | Provided By |
---|---|---|
Purity | 98% | Fluorochem |
Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
---|---|---|---|---|---|
Q862F3-1-E | Tubulin Alpha Chain (cluster #1 Of 2), Eukaryotic | Eukaryotes | 1700 | 0.35 | Binding ≤ 10μM |
Q862L2-1-E | Tubulin Alpha-1 Chain (cluster #1 Of 2), Eukaryotic | Eukaryotes | 1700 | 0.35 | Binding ≤ 10μM |
TBA1A-1-E | Tubulin Alpha-3 Chain (cluster #1 Of 3), Eukaryotic | Eukaryotes | 530 | 0.38 | Binding ≤ 10μM |
TBA4A-1-E | Tubulin Alpha-1 Chain (cluster #1 Of 1), Eukaryotic | Eukaryotes | 30 | 0.46 | Binding ≤ 10μM |
TBB1-1-E | Tubulin Beta-1 Chain (cluster #1 Of 2), Eukaryotic | Eukaryotes | 530 | 0.38 | Binding ≤ 10μM |
TBB2B-1-E | Tubulin Beta Chain (cluster #1 Of 1), Eukaryotic | Eukaryotes | 2900 | 0.34 | Binding ≤ 10μM |
Q25270-2-E | Beta Tubulin (cluster #2 Of 2), Eukaryotic | Eukaryotes | 2000 | 0.35 | Functional ≤ 10μM |
Q862F3-1-E | Tubulin Alpha Chain (cluster #1 Of 2), Eukaryotic | Eukaryotes | 660 | 0.38 | Functional ≤ 10μM |
Q862L2-1-E | Tubulin Alpha-1 Chain (cluster #1 Of 2), Eukaryotic | Eukaryotes | 660 | 0.38 | Functional ≤ 10μM |
TBA1A-1-E | Tubulin Alpha-1 Chain (cluster #1 Of 2), Eukaryotic | Eukaryotes | 530 | 0.38 | Functional ≤ 10μM |
TBA4A-1-E | Tubulin Alpha-1 Chain (cluster #1 Of 1), Eukaryotic | Eukaryotes | 4920 | 0.32 | Functional ≤ 10μM |
TBB1-1-E | Tubulin Beta-1 Chain (cluster #1 Of 2), Eukaryotic | Eukaryotes | 530 | 0.38 | Functional ≤ 10μM |
TBB2B-1-E | Tubulin Beta Chain (cluster #1 Of 2), Eukaryotic | Eukaryotes | 660 | 0.38 | Functional ≤ 10μM |
TBB3-3-E | Tubulin Beta-3 Chain (cluster #3 Of 3), Eukaryotic | Eukaryotes | 1400 | 0.36 | Functional ≤ 10μM |
TBB4A-3-E | Tubulin Beta-4 Chain (cluster #3 Of 3), Eukaryotic | Eukaryotes | 1400 | 0.36 | Functional ≤ 10μM |
TBB4B-3-E | Tubulin Beta-2 Chain (cluster #3 Of 3), Eukaryotic | Eukaryotes | 1400 | 0.36 | Functional ≤ 10μM |
TBB5-1-E | Tubulin Beta-5 Chain (cluster #1 Of 1), Eukaryotic | Eukaryotes | 1400 | 0.36 | Functional ≤ 10μM |
TBB8-3-E | Tubulin Beta-8 Chain (cluster #3 Of 3), Eukaryotic | Eukaryotes | 1400 | 0.36 | Functional ≤ 10μM |
Z100495-1-O | BMEC (Brain Microvessel Endothelial Cells) (cluster #1 Of 1), Other | Other | 4 | 0.51 | Functional ≤ 10μM |
Z100742-1-O | MeWo (Melanoma Cells) (cluster #1 Of 1), Other | Other | 4 | 0.51 | Functional ≤ 10μM |
Z103203-1-O | A375 (cluster #1 Of 3), Other | Other | 2 | 0.53 | Functional ≤ 10μM |
Z103205-1-O | A431 (cluster #1 Of 4), Other | Other | 188 | 0.41 | Functional ≤ 10μM |
Z103208-1-O | AU565 (cluster #1 Of 1), Other | Other | 4 | 0.51 | Functional ≤ 10μM |
Z103407-2-O | SW1990 (cluster #2 Of 2), Other | Other | 250 | 0.40 | Functional ≤ 10μM |
Z50591-2-O | Bos Taurus (cluster #2 Of 2), Other | Other | 2000 | 0.35 | Functional ≤ 10μM |
Z50594-1-O | Mus Musculus (cluster #1 Of 9), Other | Other | 18 | 0.47 | Functional ≤ 10μM |
Z80002-1-O | 1A9 (Ovarian Adenocarcinoma Cells) (cluster #1 Of 2), Other | Other | 4 | 0.51 | Functional ≤ 10μM |
Z80013-2-O | A10 (cluster #2 Of 2), Other | Other | 7 | 0.50 | Functional ≤ 10μM |
Z80025-1-O | ACHN (Renal Adenocarcinoma Cells) (cluster #1 Of 3), Other | Other | 2 | 0.53 | Functional ≤ 10μM |
Z80035-5-O | B16 (Melanoma Cells) (cluster #5 Of 7), Other | Other | 5 | 0.51 | Functional ≤ 10μM |
Z80064-4-O | CCRF-CEM (T-cell Leukemia) (cluster #4 Of 9), Other | Other | 2 | 0.53 | Functional ≤ 10μM |
Z80071-2-O | CEM-0 (T-cell Leukemia) (cluster #2 Of 2), Other | Other | 2 | 0.53 | Functional ≤ 10μM |
Z80099-3-O | COLO 205 (Colon Adenocarcinoma Cells) (cluster #3 Of 3), Other | Other | 2756 | 0.34 | Functional ≤ 10μM |
Z80120-1-O | DLD-1 (Colon Adenocarcinoma Cells) (cluster #1 Of 5), Other | Other | 36 | 0.45 | Functional ≤ 10μM |
Z80121-1-O | DMS-79 (Small Cell Lung Carcinoma Cells) (cluster #1 Of 1), Other | Other | 124 | 0.42 | Functional ≤ 10μM |
Z80125-9-O | DU-145 (Prostate Carcinoma) (cluster #9 Of 9), Other | Other | 9 | 0.49 | Functional ≤ 10μM |
Z80136-2-O | FM3A (Breast Carcinoma Cells) (cluster #2 Of 6), Other | Other | 42 | 0.45 | Functional ≤ 10μM |
Z80156-1-O | HL-60 (Promyeloblast Leukemia Cells) (cluster #1 Of 12), Other | Other | 4 | 0.51 | Functional ≤ 10μM |
Z80166-1-O | HT-29 (Colon Adenocarcinoma Cells) (cluster #1 Of 12), Other | Other | 94 | 0.43 | Functional ≤ 10μM |
Z80186-6-O | K562 (Erythroleukemia Cells) (cluster #6 Of 11), Other | Other | 5 | 0.51 | Functional ≤ 10μM |
Z80193-1-O | L1210 (Lymphocytic Leukemia Cells) (cluster #1 Of 12), Other | Other | 8 | 0.49 | Functional ≤ 10μM |
Z80211-2-O | LoVo (Colon Adenocarcinoma Cells) (cluster #2 Of 5), Other | Other | 3 | 0.52 | Functional ≤ 10μM |
Z80224-1-O | MCF7 (Breast Carcinoma Cells) (cluster #1 Of 14), Other | Other | 8 | 0.49 | Functional ≤ 10μM |
Z80229-1-O | MCF7-DOX (Breast Carcinoma Cells) (cluster #1 Of 1), Other | Other | 2 | 0.53 | Functional ≤ 10μM |
Z80254-1-O | MES-SA (Uterine Sarcoma Cells) (cluster #1 Of 2), Other | Other | 13 | 0.48 | Functional ≤ 10μM |
Z80255-2-O | MES-SA/DxS (Uterine Sarcoma Cells) (cluster #2 Of 2), Other | Other | 5 | 0.51 | Functional ≤ 10μM |
Z80269-1-O | MKN-45 (Gastric Adenocarcinoma Cells) (cluster #1 Of 3), Other | Other | 82 | 0.43 | Functional ≤ 10μM |
Z80284-3-O | MOLT-3 (T-lymphoblastic Leukemia Cells) (cluster #3 Of 3), Other | Other | 9 | 0.49 | Functional ≤ 10μM |
Z80285-2-O | MOLT-4 (Acute T-lymphoblastic Leukemia Cells) (cluster #2 Of 4), Other | Other | 16 | 0.47 | Functional ≤ 10μM |
Z80353-1-O | OVCAR (cluster #1 Of 1), Other | Other | 3 | 0.52 | Functional ≤ 10μM |
Z80362-1-O | P388 (Lymphoma Cells) (cluster #1 Of 8), Other | Other | 3 | 0.52 | Functional ≤ 10μM |
Z80390-1-O | PC-3 (Prostate Carcinoma Cells) (cluster #1 Of 10), Other | Other | 5400 | 0.32 | Functional ≤ 10μM |
Z80471-3-O | SH-SY5 (Bone Marrow Neuroblastoma Cells) (cluster #3 Of 3), Other | Other | 6 | 0.50 | Functional ≤ 10μM |
Z80485-3-O | SK-MEL-28 (Melanoma Cells) (cluster #3 Of 6), Other | Other | 3 | 0.52 | Functional ≤ 10μM |
Z80493-2-O | SK-OV-3 (Ovarian Carcinoma Cells) (cluster #2 Of 6), Other | Other | 6 | 0.50 | Functional ≤ 10μM |
Z80555-1-O | TSGH (cluster #1 Of 1), Other | Other | 45 | 0.45 | Functional ≤ 10μM |
Z80682-7-O | A549 (Lung Carcinoma Cells) (cluster #7 Of 11), Other | Other | 8 | 0.49 | Functional ≤ 10μM |
Z80697-3-O | Bel-7402 (Hepatoma Cells) (cluster #3 Of 3), Other | Other | 10 | 0.49 | Functional ≤ 10μM |
Z80711-1-O | NCI/ADR-RES (Breast Carcinoma Cells) (cluster #1 Of 2), Other | Other | 2 | 0.53 | Functional ≤ 10μM |
Z80792-1-O | Colon 26 (Colon Adenocarcinoma Cells) (cluster #1 Of 2), Other | Other | 9 | 0.49 | Functional ≤ 10μM |
Z80798-1-O | CPT30 Cell Line (cluster #1 Of 1), Other | Other | 7 | 0.50 | Functional ≤ 10μM |
Z80847-3-O | FaDu (Pharyngeal Carcinoma Cells) (cluster #3 Of 3), Other | Other | 2 | 0.53 | Functional ≤ 10μM |
Z80852-2-O | A-431 (Epidermoid Carcinoma Cells) (cluster #2 Of 3), Other | Other | 4 | 0.51 | Functional ≤ 10μM |
Z80874-2-O | CEM (T-cell Leukemia) (cluster #2 Of 7), Other | Other | 12 | 0.48 | Functional ≤ 10μM |
Z80896-1-O | NCI-H69 (Small Cell Lung Carcinoma Cells) (cluster #1 Of 1), Other | Other | 2 | 0.53 | Functional ≤ 10μM |
Z80900-1-O | HA22T Cell Line (cluster #1 Of 1), Other | Other | 2708 | 0.34 | Functional ≤ 10μM |
Z80928-6-O | HCT-116 (Colon Carcinoma Cells) (cluster #6 Of 9), Other | Other | 6 | 0.50 | Functional ≤ 10μM |
Z80967-2-O | Hone-1 Cell Line (cluster #2 Of 2), Other | Other | 7 | 0.50 | Functional ≤ 10μM |
Z81001-1-O | TSGH 9201 (Gastric Carcinoma Cells) (cluster #1 Of 1), Other | Other | 38 | 0.45 | Functional ≤ 10μM |
Z81020-3-O | HepG2 (Hepatoblastoma Cells) (cluster #3 Of 8), Other | Other | 6 | 0.50 | Functional ≤ 10μM |
Z81024-5-O | NCI-H460 (Non-small Cell Lung Carcinoma) (cluster #5 Of 8), Other | Other | 3 | 0.52 | Functional ≤ 10μM |
Z81034-3-O | A2780 (Ovarian Carcinoma Cells) (cluster #3 Of 10), Other | Other | 2 | 0.53 | Functional ≤ 10μM |
Z81057-1-O | HUVEC (Umbilical Vein Endothelial Cells) (cluster #1 Of 4), Other | Other | 5 | 0.51 | Functional ≤ 10μM |
Z81065-3-O | IGROV-1 (Ovarian Adenocarcinoma Cells) (cluster #3 Of 3), Other | Other | 10 | 0.49 | Functional ≤ 10μM |
Z81072-1-O | Jurkat (Acute Leukemic T-cells) (cluster #1 Of 10), Other | Other | 5 | 0.51 | Functional ≤ 10μM |
Z81115-1-O | KB (Squamous Cell Carcinoma) (cluster #1 Of 6), Other | Other | 10 | 0.49 | Functional ≤ 10μM |
Z81233-2-O | M21 (Melanoma Cells) (cluster #2 Of 2), Other | Other | 4 | 0.51 | Functional ≤ 10μM |
Z81245-1-O | MDA-MB-435 (Breast Carcinoma Cells) (cluster #1 Of 6), Other | Other | 3 | 0.52 | Functional ≤ 10μM |
Z81247-2-O | HeLa (Cervical Adenocarcinoma Cells) (cluster #2 Of 9), Other | Other | 4 | 0.51 | Functional ≤ 10μM |
Z81252-7-O | MDA-MB-231 (Breast Adenocarcinoma Cells) (cluster #7 Of 11), Other | Other | 43 | 0.45 | Functional ≤ 10μM |
Z81331-6-O | SW-620 (Colon Adenocarcinoma Cells) (cluster #6 Of 6), Other | Other | 23 | 0.46 | Functional ≤ 10μM |
Z81335-2-O | HCT-15 (Colon Adenocarcinoma Cells) (cluster #2 Of 5), Other | Other | 3 | 0.52 | Functional ≤ 10μM |
Z100495-1-O | BMEC (Brain Microvessel Endothelial Cells) (cluster #1 Of 1), Other | Other | 4 | 0.51 | ADME/T ≤ 10μM |
Z80013-2-O | A10 (cluster #2 Of 2), Other | Other | 23 | 0.46 | ADME/T ≤ 10μM |
Z80390-1-O | PC-3 (Prostate Carcinoma Cells) (cluster #1 Of 2), Other | Other | 3 | 0.52 | ADME/T ≤ 10μM |
Z80608-1-O | ZR-75-1 (Breast Carcinoma Cells) (cluster #1 Of 1), Other | Other | 0 | 0.00 | ADME/T ≤ 10μM |
Z80874-1-O | CEM (T-cell Leukemia) (cluster #1 Of 4), Other | Other | 2 | 0.53 | ADME/T ≤ 10μM |
Z80928-1-O | HCT-116 (Colon Carcinoma Cells) (cluster #1 Of 2), Other | Other | 0 | 0.00 | ADME/T ≤ 10μM |
Z81057-2-O | HUVEC (Umbilical Vein Endothelial Cells) (cluster #2 Of 5), Other | Other | 5 | 0.51 | ADME/T ≤ 10μM |
Z81247-1-O | HeLa (Cervical Adenocarcinoma Cells) (cluster #1 Of 3), Other | Other | 3 | 0.52 | ADME/T ≤ 10μM |
Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
---|---|---|---|---|---|
TBA1A_PIG | P02550 | Tubulin Alpha Chain, Pig | 530 | 0.38 | Binding ≤ 1μM |
TBA4A_HUMAN | P68366 | Tubulin Alpha-1 Chain, Human | 12.9 | 0.48 | Binding ≤ 1μM |
TBA1A_RAT | P68370 | Tubulin Alpha-1 Chain, Rat | 530 | 0.38 | Binding ≤ 1μM |
TBB2B_BOVIN | Q6B856 | Tubulin Beta Chain, Bovin | 180 | 0.41 | Binding ≤ 1μM |
TBB1_HUMAN | Q9H4B7 | Tubulin Beta-1 Chain, Human | 12.9 | 0.48 | Binding ≤ 1μM |
Q862F3_BOVIN | Q862F3 | Tubulin Alpha Chain, Bovin | 1200 | 0.36 | Binding ≤ 10μM |
TBA1A_PIG | P02550 | Tubulin Alpha Chain, Pig | 1200 | 0.36 | Binding ≤ 10μM |
Q862L2_BOVIN | Q862L2 | Tubulin Alpha-1 Chain, Bovin | 1200 | 0.36 | Binding ≤ 10μM |
TBA1A_RAT | P68370 | Tubulin Alpha-1 Chain, Rat | 530 | 0.38 | Binding ≤ 10μM |
TBA4A_HUMAN | P68366 | Tubulin Alpha-1 Chain, Human | 12.9 | 0.48 | Binding ≤ 10μM |
TBB2B_BOVIN | Q6B856 | Tubulin Beta Chain, Bovin | 1200 | 0.36 | Binding ≤ 10μM |
TBB1_HUMAN | Q9H4B7 | Tubulin Beta-1 Chain, Human | 12.9 | 0.48 | Binding ≤ 10μM |
Z80002 | Z80002 | 1A9 (Ovarian Adenocarcinoma Cells) | 3.6 | 0.51 | Functional ≤ 10μM |
Z80852 | Z80852 | A-431 (Epidermoid Carcinoma Cells) | 3.5 | 0.51 | Functional ≤ 10μM |
Z80013 | Z80013 | A10 | 7 | 0.50 | Functional ≤ 10μM |
Z81034 | Z81034 | A2780 (Ovarian Carcinoma Cells) | 1.66 | 0.53 | Functional ≤ 10μM |
Z103203 | Z103203 | A375 | 2.1 | 0.53 | Functional ≤ 10μM |
Z103205 | Z103205 | A431 | 188 | 0.41 | Functional ≤ 10μM |
Z80682 | Z80682 | A549 (Lung Carcinoma Cells) | 117 | 0.42 | Functional ≤ 10μM |
Z80025 | Z80025 | ACHN (Renal Adenocarcinoma Cells) | 1.6 | 0.54 | Functional ≤ 10μM |
Z103208 | Z103208 | AU565 | 4.4 | 0.51 | Functional ≤ 10μM |
Z80035 | Z80035 | B16 (Melanoma Cells) | 1 | 0.55 | Functional ≤ 10μM |
Z80697 | Z80697 | Bel-7402 (Hepatoma Cells) | 10 | 0.49 | Functional ≤ 10μM |
Q25270_LEIDO | Q25270 | Beta Tubulin, Leido | 1900 | 0.35 | Functional ≤ 10μM |
Z100495 | Z100495 | BMEC (Brain Microvessel Endothelial Cells) | 3.7 | 0.51 | Functional ≤ 10μM |
Z50591 | Z50591 | Bos Taurus | 1600 | 0.35 | Functional ≤ 10μM |
Z80064 | Z80064 | CCRF-CEM (T-cell Leukemia) | 2 | 0.53 | Functional ≤ 10μM |
Z80874 | Z80874 | CEM (T-cell Leukemia) | 1.9 | 0.53 | Functional ≤ 10μM |
Z80071 | Z80071 | CEM-0 (T-cell Leukemia) | 1.9 | 0.53 | Functional ≤ 10μM |
Z80099 | Z80099 | COLO 205 (Colon Adenocarcinoma Cells) | 2756 | 0.34 | Functional ≤ 10μM |
Z80792 | Z80792 | Colon 26 (Colon Adenocarcinoma Cells) | 18 | 0.47 | Functional ≤ 10μM |
Z80798 | Z80798 | CPT30 Cell Line | 6.9 | 0.50 | Functional ≤ 10μM |
Z80120 | Z80120 | DLD-1 (Colon Adenocarcinoma Cells) | 36 | 0.45 | Functional ≤ 10μM |
Z80121 | Z80121 | DMS-79 (Small Cell Lung Carcinoma Cells) | 124 | 0.42 | Functional ≤ 10μM |
Z80125 | Z80125 | DU-145 (Prostate Carcinoma) | 32 | 0.46 | Functional ≤ 10μM |
Z80847 | Z80847 | FaDu (Pharyngeal Carcinoma Cells) | 1.9 | 0.53 | Functional ≤ 10μM |
Z80136 | Z80136 | FM3A (Breast Carcinoma Cells) | 42 | 0.45 | Functional ≤ 10μM |
Z80900 | Z80900 | HA22T Cell Line | 2708 | 0.34 | Functional ≤ 10μM |
Z80928 | Z80928 | HCT-116 (Colon Carcinoma Cells) | 0.9 | 0.55 | Functional ≤ 10μM |
Z81335 | Z81335 | HCT-15 (Colon Adenocarcinoma Cells) | 1 | 0.55 | Functional ≤ 10μM |
Z81247 | Z81247 | HeLa (Cervical Adenocarcinoma Cells) | 0.51 | 0.57 | Functional ≤ 10μM |
Z81020 | Z81020 | HepG2 (Hepatoblastoma Cells) | 0.14 | 0.60 | Functional ≤ 10μM |
Z80156 | Z80156 | HL-60 (Promyeloblast Leukemia Cells) | 0.1 | 0.61 | Functional ≤ 10μM |
Z80967 | Z80967 | Hone-1 Cell Line | 4 | 0.51 | Functional ≤ 10μM |
Z80166 | Z80166 | HT-29 (Colon Adenocarcinoma Cells) | 118 | 0.42 | Functional ≤ 10μM |
Z81057 | Z81057 | HUVEC (Umbilical Vein Endothelial Cells) | 1.5 | 0.54 | Functional ≤ 10μM |
Z81065 | Z81065 | IGROV-1 (Ovarian Adenocarcinoma Cells) | 10.3 | 0.49 | Functional ≤ 10μM |
Z81072 | Z81072 | Jurkat (Acute Leukemic T-cells) | 5 | 0.51 | Functional ≤ 10μM |
Z80186 | Z80186 | K562 (Erythroleukemia Cells) | 1.4 | 0.54 | Functional ≤ 10μM |
Z81115 | Z81115 | KB (Squamous Cell Carcinoma) | 1.5 | 0.54 | Functional ≤ 10μM |
Z80193 | Z80193 | L1210 (Lymphocytic Leukemia Cells) | 2 | 0.53 | Functional ≤ 10μM |
Z80211 | Z80211 | LoVo (Colon Adenocarcinoma Cells) | 2.9 | 0.52 | Functional ≤ 10μM |
Z81233 | Z81233 | M21 (Melanoma Cells) | 4.3 | 0.51 | Functional ≤ 10μM |
Z80224 | Z80224 | MCF7 (Breast Carcinoma Cells) | 11 | 0.48 | Functional ≤ 10μM |
Z80229 | Z80229 | MCF7-DOX (Breast Carcinoma Cells) | 2.3 | 0.53 | Functional ≤ 10μM |
Z81252 | Z81252 | MDA-MB-231 (Breast Adenocarcinoma Cells) | 3 | 0.52 | Functional ≤ 10μM |
Z81245 | Z81245 | MDA-MB-435 (Breast Carcinoma Cells) | 3 | 0.52 | Functional ≤ 10μM |
Z80254 | Z80254 | MES-SA (Uterine Sarcoma Cells) | 13 | 0.48 | Functional ≤ 10μM |
Z80255 | Z80255 | MES-SA/DxS (Uterine Sarcoma Cells) | 4 | 0.51 | Functional ≤ 10μM |
Z100742 | Z100742 | MeWo (Melanoma Cells) | 4 | 0.51 | Functional ≤ 10μM |
Z80269 | Z80269 | MKN-45 (Gastric Adenocarcinoma Cells) | 52 | 0.44 | Functional ≤ 10μM |
Z80284 | Z80284 | MOLT-3 (T-lymphoblastic Leukemia Cells) | 9.3 | 0.49 | Functional ≤ 10μM |
Z80285 | Z80285 | MOLT-4 (Acute T-lymphoblastic Leukemia Cells) | 1.6 | 0.54 | Functional ≤ 10μM |
Z50594 | Z50594 | Mus Musculus | 18 | 0.47 | Functional ≤ 10μM |
Z81024 | Z81024 | NCI-H460 (Non-small Cell Lung Carcinoma) | 1.24 | 0.54 | Functional ≤ 10μM |
Z80896 | Z80896 | NCI-H69 (Small Cell Lung Carcinoma Cells) | 1.7 | 0.53 | Functional ≤ 10μM |
Z80711 | Z80711 | NCI/ADR-RES (Breast Carcinoma Cells) | 1.5 | 0.54 | Functional ≤ 10μM |
Z80353 | Z80353 | OVCAR | 3.3 | 0.52 | Functional ≤ 10μM |
Z80362 | Z80362 | P388 (Lymphoma Cells) | 160 | 0.41 | Functional ≤ 10μM |
Z80390 | Z80390 | PC-3 (Prostate Carcinoma Cells) | 2.7 | 0.52 | Functional ≤ 10μM |
Z80471 | Z80471 | SH-SY5 (Bone Marrow Neuroblastoma Cells) | 1.5 | 0.54 | Functional ≤ 10μM |
Z80485 | Z80485 | SK-MEL-28 (Melanoma Cells) | 3.16227766 | 0.52 | Functional ≤ 10μM |
Z80493 | Z80493 | SK-OV-3 (Ovarian Carcinoma Cells) | 1800 | 0.35 | Functional ≤ 10μM |
Z81331 | Z81331 | SW-620 (Colon Adenocarcinoma Cells) | 23 | 0.46 | Functional ≤ 10μM |
Z103407 | Z103407 | SW1990 | 250 | 0.40 | Functional ≤ 10μM |
Z80555 | Z80555 | TSGH | 45 | 0.45 | Functional ≤ 10μM |
Z81001 | Z81001 | TSGH 9201 (Gastric Carcinoma Cells) | 38 | 0.45 | Functional ≤ 10μM |
TBA1A_PIG | P02550 | Tubulin Alpha Chain, Pig | 1000 | 0.37 | Functional ≤ 10μM |
Q862F3_BOVIN | Q862F3 | Tubulin Alpha Chain, Bovin | 1100 | 0.36 | Functional ≤ 10μM |
TBA1A_RAT | P68370 | Tubulin Alpha-1 Chain, Rat | 1000 | 0.37 | Functional ≤ 10μM |
TBA4A_HUMAN | P68366 | Tubulin Alpha-1 Chain, Human | 2100 | 0.35 | Functional ≤ 10μM |
Q862L2_BOVIN | Q862L2 | Tubulin Alpha-1 Chain, Bovin | 1100 | 0.36 | Functional ≤ 10μM |
TBB2B_BOVIN | Q6B856 | Tubulin Beta Chain, Bovin | 1100 | 0.36 | Functional ≤ 10μM |
TBB1_HUMAN | Q9H4B7 | Tubulin Beta-1 Chain, Human | 1000 | 0.37 | Functional ≤ 10μM |
TBB4B_HUMAN | P68371 | Tubulin Beta-2 Chain, Human | 1000 | 0.37 | Functional ≤ 10μM |
TBB3_HUMAN | Q13509 | Tubulin Beta-3 Chain, Human | 1000 | 0.37 | Functional ≤ 10μM |
TBB4A_HUMAN | P04350 | Tubulin Beta-4 Chain, Human | 1000 | 0.37 | Functional ≤ 10μM |
TBB5_HUMAN | P07437 | Tubulin Beta-5 Chain, Human | 1200 | 0.36 | Functional ≤ 10μM |
TBB8_HUMAN | Q3ZCM7 | Tubulin Beta-8 Chain, Human | 1000 | 0.37 | Functional ≤ 10μM |
Z80013 | Z80013 | A10 | 23 | 0.46 | ADME/T ≤ 10μM |
Z100495 | Z100495 | BMEC (Brain Microvessel Endothelial Cells) | 3.7 | 0.51 | ADME/T ≤ 10μM |
Z80874 | Z80874 | CEM (T-cell Leukemia) | 1.9 | 0.53 | ADME/T ≤ 10μM |
Z80928 | Z80928 | HCT-116 (Colon Carcinoma Cells) | 0.35 | 0.58 | ADME/T ≤ 10μM |
Z81247 | Z81247 | HeLa (Cervical Adenocarcinoma Cells) | 0.3 | 0.58 | ADME/T ≤ 10μM |
Z81057 | Z81057 | HUVEC (Umbilical Vein Endothelial Cells) | 2.5 | 0.52 | ADME/T ≤ 10μM |
Z80390 | Z80390 | PC-3 (Prostate Carcinoma Cells) | 3.2 | 0.52 | ADME/T ≤ 10μM |
Z80608 | Z80608 | ZR-75-1 (Breast Carcinoma Cells) | 0.24 | 0.59 | ADME/T ≤ 10μM |
Description | Species |
---|---|
Formation of tubulin folding intermediates by CCT/TriC | |
Gap junction assembly | |
Kinesins | |
Loss of Nlp from mitotic centrosomes | |
Loss of proteins required for interphase microtubule organization from the ce | |
MHC class II antigen presentation | |
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | |
Mitotic Prometaphase | |
Platelet degranulation | |
Post-chaperonin tubulin folding pathway | |
Prefoldin mediated transfer of substrate to CCT/TriC | |
Recruitment of mitotic centrosome proteins and complexes | |
Recruitment of NuMA to mitotic centrosomes | |
Recycling pathway of L1 | |
Regulation of PLK1 Activity at G2/M Transition | |
Resolution of Sister Chromatid Cohesion | |
Separation of Sister Chromatids | |
Translocation of GLUT4 to the plasma membrane |
No pre-computed analogs available. Try a structural similarity search.