| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| June 23rd, 2008 | 32 | Yes |
None
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 3.03 | 7.2 | -49.79 | 3 | 8 | 1 | 88 | 433.488 | 4 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| ALK-1-E | ALK Tyrosine Kinase Receptor (cluster #1 Of 1), Eukaryotic | Eukaryotes | 700 | 0.27 | Binding ≤ 10μM |
| FLT3-1-E | Tyrosine-protein Kinase Receptor FLT3 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 5000 | 0.23 | Binding ≤ 10μM |
| INSR-1-E | Insulin Receptor (cluster #1 Of 1), Eukaryotic | Eukaryotes | 8800 | 0.22 | Binding ≤ 10μM |
| ABL1-1-E | Tyrosine-protein Kinase ABL (cluster #1 Of 2), Eukaryotic | Eukaryotes | 3800 | 0.24 | Functional ≤ 10μM |
| ALK-1-E | ALK Tyrosine Kinase Receptor (cluster #1 Of 1), Eukaryotic | Eukaryotes | 6500 | 0.23 | Functional ≤ 10μM |
| BCR-1-E | Breakpoint Cluster Region Protein (cluster #1 Of 2), Eukaryotic | Eukaryotes | 3800 | 0.24 | Functional ≤ 10μM |
| NPM-1-E | Nucleophosmin (cluster #1 Of 1), Eukaryotic | Eukaryotes | 6500 | 0.23 | Functional ≤ 10μM |
| Z80036-1-O | BaF3 (IL-3-dependent Pro-B-cells) (cluster #1 Of 3), Other | Other | 6500 | 0.23 | Functional ≤ 10μM |
| Z81072-1-O | Jurkat (Acute Leukemic T-cells) (cluster #1 Of 10), Other | Other | 3500 | 0.24 | Functional ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| ALK_HUMAN | Q9UM73 | ALK Tyrosine Kinase Receptor, Human | 600 | 0.27 | Binding ≤ 1μM |
| ALK_HUMAN | Q9UM73 | ALK Tyrosine Kinase Receptor, Human | 600 | 0.27 | Binding ≤ 10μM |
| INSR_HUMAN | P06213 | Insulin Receptor, Human | 4800 | 0.23 | Binding ≤ 10μM |
| FLT3_HUMAN | P36888 | Tyrosine-protein Kinase Receptor FLT3, Human | 5000 | 0.23 | Binding ≤ 10μM |
| ALK_HUMAN | Q9UM73 | ALK Tyrosine Kinase Receptor, Human | 3600 | 0.24 | Functional ≤ 10μM |
| Z80036 | Z80036 | BaF3 (IL-3-dependent Pro-B-cells) | 6500 | 0.23 | Functional ≤ 10μM |
| BCR_HUMAN | P11274 | Breakpoint Cluster Region Protein, Human | 3800 | 0.24 | Functional ≤ 10μM |
| Z81072 | Z81072 | Jurkat (Acute Leukemic T-cells) | 3500 | 0.24 | Functional ≤ 10μM |
| NPM_HUMAN | P06748 | Nucleophosmin, Human | 3600 | 0.24 | Functional ≤ 10μM |
| ABL1_HUMAN | P00519 | Tyrosine-protein Kinase ABL, Human | 3800 | 0.24 | Functional ≤ 10μM |
| Description | Species |
|---|---|
| CDO in myogenesis | |
| Deposition of new CENPA-containing nucleosomes at the centromere | |
| Factors involved in megakaryocyte development and platelet production | |
| Insulin receptor recycling | |
| IRS activation | |
| Nuclear import of Rev protein | |
| Regulation of actin dynamics for phagocytic cup formation | |
| Rho GTPase cycle | |
| Role of Abl in Robo-Slit signaling | |
| SHC activation | |
| Signal attenuation | |
| Signaling by FGFR1 fusion mutants | |
| Signaling by Insulin receptor |
No pre-computed analogs available. Try a structural similarity search.
