| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| June 26th, 2008 | 31 | No |
Popular Name: Leupeptin acid Leupeptin acid
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | -2.00 | 4.31 | -74.88 | 8 | 11 | 0 | 193 | 442.561 | 14 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| CAN1-1-E | Calpain 1 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 80 | 0.32 | Binding ≤ 10μM |
| CATB-1-E | Cathepsin B (cluster #1 Of 6), Eukaryotic | Eukaryotes | 9 | 0.36 | Binding ≤ 10μM |
| CATL1-1-E | Cathepsin L (cluster #1 Of 5), Eukaryotic | Eukaryotes | 70 | 0.32 | Binding ≤ 10μM |
| CATL2-1-E | Cathepsin L2 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 70 | 0.32 | Binding ≤ 10μM |
| CPNS1-1-E | Calpain Small Subunit 1 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 80 | 0.32 | Binding ≤ 10μM |
| PLMN-2-E | Plasminogen (cluster #2 Of 2), Eukaryotic | Eukaryotes | 3700 | 0.25 | Binding ≤ 10μM |
| Q95WR6-1-E | Cysteine Protease (cluster #1 Of 1), Eukaryotic | Eukaryotes | 10 | 0.36 | Binding ≤ 10μM |
| Q9N6S8-1-E | Falcipain 2 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 6 | 0.37 | Binding ≤ 10μM |
| Q9NAW4-1-E | Cysteine Protease Falcipain-3 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 98 | 0.32 | Binding ≤ 10μM |
| Q9NBD4-1-E | Cysteine Protease Falcipain-2 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 98 | 0.32 | Binding ≤ 10μM |
| ST14-1-E | Matriptase (cluster #1 Of 1), Eukaryotic | Eukaryotes | 1900 | 0.26 | Binding ≤ 10μM |
| TRY1-3-E | Trypsin I (cluster #3 Of 5), Eukaryotic | Eukaryotes | 8100 | 0.23 | Binding ≤ 10μM |
| Z50426-8-O | Plasmodium Falciparum (isolate K1 / Thailand) (cluster #8 Of 9), Other | Other | 6260 | 0.23 | Functional ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| CAN1_HUMAN | P07384 | Calpain 1, Human | 300 | 0.29 | Binding ≤ 1μM |
| CAN1_PIG | P35750 | Calpain 1, Pig | 80 | 0.32 | Binding ≤ 1μM |
| CPNS1_PIG | P04574 | Calpain Small Subunit 1, Pig | 80 | 0.32 | Binding ≤ 1μM |
| CATB_BOVIN | P07688 | Cathepsin B, Bovin | 310 | 0.29 | Binding ≤ 1μM |
| CATB_HUMAN | P07858 | Cathepsin B, Human | 117 | 0.31 | Binding ≤ 1μM |
| CATL1_HUMAN | P07711 | Cathepsin L, Human | 2.5 | 0.39 | Binding ≤ 1μM |
| CATL2_HUMAN | O60911 | Cathepsin L2, Human | 70.3 | 0.32 | Binding ≤ 1μM |
| Q95WR6_LEIDO | Q95WR6 | Cysteine Protease, Leido | 10 | 0.36 | Binding ≤ 1μM |
| Q9NBD4_PLAFA | Q9NBD4 | Cysteine Protease Falcipain-2, Plafa | 87 | 0.32 | Binding ≤ 1μM |
| Q9NAW4_PLAFA | Q9NAW4 | Cysteine Protease Falcipain-3, Plafa | 87 | 0.32 | Binding ≤ 1μM |
| Q9N6S8_PLAFA | Q9N6S8 | Falcipain 2, Plafa | 5.8 | 0.37 | Binding ≤ 1μM |
| CAN1_HUMAN | P07384 | Calpain 1, Human | 300 | 0.29 | Binding ≤ 10μM |
| CAN1_PIG | P35750 | Calpain 1, Pig | 80 | 0.32 | Binding ≤ 10μM |
| CPNS1_PIG | P04574 | Calpain Small Subunit 1, Pig | 80 | 0.32 | Binding ≤ 10μM |
| CATB_HUMAN | P07858 | Cathepsin B, Human | 117 | 0.31 | Binding ≤ 10μM |
| CATB_BOVIN | P07688 | Cathepsin B, Bovin | 310 | 0.29 | Binding ≤ 10μM |
| CATL1_HUMAN | P07711 | Cathepsin L, Human | 2.5 | 0.39 | Binding ≤ 10μM |
| CATL2_HUMAN | O60911 | Cathepsin L2, Human | 70.3 | 0.32 | Binding ≤ 10μM |
| Q95WR6_LEIDO | Q95WR6 | Cysteine Protease, Leido | 10 | 0.36 | Binding ≤ 10μM |
| Q9NBD4_PLAFA | Q9NBD4 | Cysteine Protease Falcipain-2, Plafa | 87 | 0.32 | Binding ≤ 10μM |
| Q9NAW4_PLAFA | Q9NAW4 | Cysteine Protease Falcipain-3, Plafa | 87 | 0.32 | Binding ≤ 10μM |
| Q9N6S8_PLAFA | Q9N6S8 | Falcipain 2, Plafa | 5.8 | 0.37 | Binding ≤ 10μM |
| ST14_HUMAN | Q9Y5Y6 | Matriptase, Human | 1900 | 0.26 | Binding ≤ 10μM |
| PLMN_BOVIN | P06868 | Plasminogen, Bovin | 3700 | 0.25 | Binding ≤ 10μM |
| PLMN_HUMAN | P00747 | Plasminogen, Human | 1200 | 0.27 | Binding ≤ 10μM |
| TRY1_BOVIN | P00760 | Trypsin I, Bovin | 8100 | 0.23 | Binding ≤ 10μM |
| Z50426 | Z50426 | Plasmodium Falciparum (isolate K1 / Thailand) | 6260 | 0.23 | Functional ≤ 10μM |
| Description | Species |
|---|---|
| Activation of Matrix Metalloproteinases | |
| Assembly of collagen fibrils and other multimeric structures | |
| Collagen degradation | |
| Degradation of the extracellular matrix | |
| Dissolution of Fibrin Clot | |
| Endosomal/Vacuolar pathway | |
| MHC class II antigen presentation | |
| Platelet degranulation | |
| Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l | |
| Signaling by PDGF | |
| Trafficking and processing of endosomal TLR |
