| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| February 6th, 2009 | 13 | Yes |
Popular Name: (2S)-2-amino-3-(4-chloro-3-hydroxy-isoxazol-5-yl)propanoic (2S)-2-amino-3-(4-chloro-3-hydro…
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CAS Number: 909400-43-7
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | -2.45 | -0.69 | -40.56 | 3 | 6 | -1 | 112 | 205.577 | 3 | ↓ |
| Mid Mid (pH 6-8) | -2.00 | -2.71 | -32.85 | 4 | 6 | 0 | 114 | 206.585 | 3 | ↓ |
| Mid Mid (pH 6-8) | -2.00 | -2.24 | -90.61 | 2 | 6 | -2 | 115 | 204.569 | 3 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| GRIA1-1-E | Glutamate Receptor Ionotropic, AMPA 1 (cluster #1 Of 4), Eukaryotic | Eukaryotes | 130 | 0.74 | Binding ≤ 10μM |
| GRIA2-4-E | Glutamate Receptor Ionotropic, AMPA 2 (cluster #4 Of 4), Eukaryotic | Eukaryotes | 370 | 0.69 | Binding ≤ 10μM |
| GRIK1-1-E | Glutamate Receptor Ionotropic Kainate 1 (cluster #1 Of 3), Eukaryotic | Eukaryotes | 6800 | 0.56 | Binding ≤ 10μM |
| GRIA1-1-E | Glutamate Receptor Ionotropic, AMPA 1 (cluster #1 Of 3), Eukaryotic | Eukaryotes | 4700 | 0.57 | Functional ≤ 10μM |
| GRIA2-2-E | Glutamate Receptor Ionotropic, AMPA 2 (cluster #2 Of 4), Eukaryotic | Eukaryotes | 1700 | 0.62 | Functional ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| GRIA1_HUMAN | P42261 | Glutamate Receptor Ionotropic, AMPA 1, Human | 130 | 0.74 | Binding ≤ 1μM |
| GRIA1_RAT | P19490 | Glutamate Receptor Ionotropic, AMPA 1, Rat | 130 | 0.74 | Binding ≤ 1μM |
| GRIA2_HUMAN | P42262 | Glutamate Receptor Ionotropic, AMPA 2, Human | 370 | 0.69 | Binding ≤ 1μM |
| GRIA2_RAT | P19491 | Glutamate Receptor Ionotropic, AMPA 2, Rat | 370 | 0.69 | Binding ≤ 1μM |
| GRIK1_RAT | P22756 | Glutamate Receptor Ionotropic Kainate 1, Rat | 6800 | 0.56 | Binding ≤ 10μM |
| GRIK1_HUMAN | P39086 | Glutamate Receptor Ionotropic Kainate 1, Human | 6800 | 0.56 | Binding ≤ 10μM |
| GRIA1_RAT | P19490 | Glutamate Receptor Ionotropic, AMPA 1, Rat | 130 | 0.74 | Binding ≤ 10μM |
| GRIA1_HUMAN | P42261 | Glutamate Receptor Ionotropic, AMPA 1, Human | 130 | 0.74 | Binding ≤ 10μM |
| GRIA2_RAT | P19491 | Glutamate Receptor Ionotropic, AMPA 2, Rat | 370 | 0.69 | Binding ≤ 10μM |
| GRIA2_HUMAN | P42262 | Glutamate Receptor Ionotropic, AMPA 2, Human | 370 | 0.69 | Binding ≤ 10μM |
| GRIA1_HUMAN | P42261 | Glutamate Receptor Ionotropic, AMPA 1, Human | 4100 | 0.58 | Functional ≤ 10μM |
| GRIA1_MOUSE | P23818 | Glutamate Receptor Ionotropic, AMPA 1, Mouse | 4700 | 0.57 | Functional ≤ 10μM |
| GRIA1_RAT | P19490 | Glutamate Receptor Ionotropic, AMPA 1, Rat | 4700 | 0.57 | Functional ≤ 10μM |
| GRIA2_RAT | P19491 | Glutamate Receptor Ionotropic, AMPA 2, Rat | 1700 | 0.62 | Functional ≤ 10μM |
| GRIA2_HUMAN | P42262 | Glutamate Receptor Ionotropic, AMPA 2, Human | 1700 | 0.62 | Functional ≤ 10μM |
| Description | Species |
|---|---|
| Activation of AMPA receptors | |
| Activation of Ca-permeable Kainate Receptor | |
| Activation of Na-permeable Kainate Receptors | |
| Trafficking of AMPA receptors | |
| Trafficking of GluR2-containing AMPA receptors | |
| Unblocking of NMDA receptor, glutamate binding and activation |
