| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| February 14th, 2009 | 17 | No |
Popular Name: (2S)-2-amino-3-(5-nitro-2,4-dioxo-pyrimidin-1-yl)propanoic (2S)-2-amino-3-(5-nitro-2,4-diox…
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | -3.61 | -1.5 | -58.63 | 3 | 10 | -1 | 172 | 243.155 | 4 | ↓ |
| Hi High (pH 8-9.5) | -3.61 | -1.72 | -91.85 | 2 | 10 | -2 | 170 | 242.147 | 4 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| GRIA1-2-E | Glutamate Receptor Ionotropic, AMPA 1 (cluster #2 Of 4), Eukaryotic | Eukaryotes | 120 | 0.57 | Binding ≤ 10μM |
| GRIA1-2-E | Glutamate Receptor Ionotropic, AMPA 1 (cluster #2 Of 4), Eukaryotic | Eukaryotes | 279 | 0.54 | Binding ≤ 10μM |
| GRIA2-4-E | Glutamate Receptor Ionotropic, AMPA 2 (cluster #4 Of 4), Eukaryotic | Eukaryotes | 115 | 0.57 | Binding ≤ 10μM |
| GRIA2-4-E | Glutamate Receptor Ionotropic, AMPA 2 (cluster #4 Of 4), Eukaryotic | Eukaryotes | 120 | 0.57 | Binding ≤ 10μM |
| GRIA3-4-E | Glutamate Receptor Ionotropic, AMPA 3 (cluster #4 Of 4), Eukaryotic | Eukaryotes | 120 | 0.57 | Binding ≤ 10μM |
| GRIA4-4-E | Glutamate Receptor Ionotropic, AMPA 4 (cluster #4 Of 5), Eukaryotic | Eukaryotes | 120 | 0.57 | Binding ≤ 10μM |
| GRIA4-4-E | Glutamate Receptor Ionotropic, AMPA 4 (cluster #4 Of 5), Eukaryotic | Eukaryotes | 207 | 0.55 | Binding ≤ 10μM |
| GRIK1-2-E | Glutamate Receptor Ionotropic Kainate 1 (cluster #2 Of 3), Eukaryotic | Eukaryotes | 3700 | 0.45 | Binding ≤ 10μM |
| GRIK2-1-E | Glutamate Receptor Ionotropic Kainate 2 (cluster #1 Of 3), Eukaryotic | Eukaryotes | 3700 | 0.45 | Binding ≤ 10μM |
| GRIK3-1-E | Glutamate Receptor Ionotropic Kainate 3 (cluster #1 Of 3), Eukaryotic | Eukaryotes | 3700 | 0.45 | Binding ≤ 10μM |
| GRIK4-1-E | Glutamate Receptor Ionotropic Kainate 4 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 3700 | 0.45 | Binding ≤ 10μM |
| GRIK5-1-E | Glutamate Receptor Ionotropic Kainate 5 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 393 | 0.53 | Binding ≤ 10μM |
| GRIK5-1-E | Glutamate Receptor Ionotropic Kainate 5 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 3700 | 0.45 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| GRIK5_HUMAN | Q16478 | Glutamate Receptor Ionotropic Kainate 5, Human | 393 | 0.53 | Binding ≤ 1μM |
| GRIA1_HUMAN | P42261 | Glutamate Receptor Ionotropic, AMPA 1, Human | 279 | 0.54 | Binding ≤ 1μM |
| GRIA1_MOUSE | P23818 | Glutamate Receptor Ionotropic, AMPA 1, Mouse | 120 | 0.57 | Binding ≤ 1μM |
| GRIA2_HUMAN | P42262 | Glutamate Receptor Ionotropic, AMPA 2, Human | 115 | 0.57 | Binding ≤ 1μM |
| GRIA2_RAT | P19491 | Glutamate Receptor Ionotropic, AMPA 2, Rat | 120 | 0.57 | Binding ≤ 1μM |
| GRIA3_RAT | P19492 | Glutamate Receptor Ionotropic, AMPA 3, Rat | 120 | 0.57 | Binding ≤ 1μM |
| GRIA4_RAT | P19493 | Glutamate Receptor Ionotropic, AMPA 4, Rat | 120 | 0.57 | Binding ≤ 1μM |
| GRIA4_HUMAN | P48058 | Glutamate Receptor Ionotropic, AMPA 4, Human | 207 | 0.55 | Binding ≤ 1μM |
| GRIK1_RAT | P22756 | Glutamate Receptor Ionotropic Kainate 1, Rat | 3700 | 0.45 | Binding ≤ 10μM |
| GRIK2_RAT | P42260 | Glutamate Receptor Ionotropic Kainate 2, Rat | 3700 | 0.45 | Binding ≤ 10μM |
| GRIK3_RAT | P42264 | Glutamate Receptor Ionotropic Kainate 3, Rat | 3700 | 0.45 | Binding ≤ 10μM |
| GRIK4_RAT | Q01812 | Glutamate Receptor Ionotropic Kainate 4, Rat | 3700 | 0.45 | Binding ≤ 10μM |
| GRIK5_RAT | Q63273 | Glutamate Receptor Ionotropic Kainate 5, Rat | 3700 | 0.45 | Binding ≤ 10μM |
| GRIK5_HUMAN | Q16478 | Glutamate Receptor Ionotropic Kainate 5, Human | 393 | 0.53 | Binding ≤ 10μM |
| GRIA1_HUMAN | P42261 | Glutamate Receptor Ionotropic, AMPA 1, Human | 279 | 0.54 | Binding ≤ 10μM |
| GRIA1_MOUSE | P23818 | Glutamate Receptor Ionotropic, AMPA 1, Mouse | 120 | 0.57 | Binding ≤ 10μM |
| GRIA2_HUMAN | P42262 | Glutamate Receptor Ionotropic, AMPA 2, Human | 115 | 0.57 | Binding ≤ 10μM |
| GRIA2_RAT | P19491 | Glutamate Receptor Ionotropic, AMPA 2, Rat | 120 | 0.57 | Binding ≤ 10μM |
| GRIA3_RAT | P19492 | Glutamate Receptor Ionotropic, AMPA 3, Rat | 120 | 0.57 | Binding ≤ 10μM |
| GRIA4_RAT | P19493 | Glutamate Receptor Ionotropic, AMPA 4, Rat | 120 | 0.57 | Binding ≤ 10μM |
| GRIA4_HUMAN | P48058 | Glutamate Receptor Ionotropic, AMPA 4, Human | 207 | 0.55 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| Activation of AMPA receptors | |
| Activation of Ca-permeable Kainate Receptor | |
| Activation of Na-permeable Kainate Receptors | |
| Trafficking of AMPA receptors | |
| Trafficking of GluR2-containing AMPA receptors | |
| Unblocking of NMDA receptor, glutamate binding and activation |
No pre-computed analogs available. Try a structural similarity search.