| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| September 9th, 2009 | 33 | No |
Popular Name: DNC003727 DNC003727
None
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 4.53 | 8.99 | -11.5 | 2 | 4 | 0 | 61 | 449.635 | 5 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| ANDR-2-E | Androgen Receptor (cluster #2 Of 4), Eukaryotic | Eukaryotes | 269 | 0.28 | Binding ≤ 10μM |
| ESR1-2-E | Estrogen Receptor Alpha (cluster #2 Of 5), Eukaryotic | Eukaryotes | 20 | 0.33 | Binding ≤ 10μM |
| ESR2-2-E | Estrogen Receptor Beta (cluster #2 Of 4), Eukaryotic | Eukaryotes | 20 | 0.33 | Binding ≤ 10μM |
| GCR-2-E | Glucocorticoid Receptor (cluster #2 Of 2), Eukaryotic | Eukaryotes | 42 | 0.31 | Binding ≤ 10μM |
| PRGR-1-E | Progesterone Receptor (cluster #1 Of 3), Eukaryotic | Eukaryotes | 3 | 0.36 | Binding ≤ 10μM |
| ANDR-2-E | Androgen Receptor (cluster #2 Of 3), Eukaryotic | Eukaryotes | 269 | 0.28 | Functional ≤ 10μM |
| GCR-2-E | Glucocorticoid Receptor (cluster #2 Of 2), Eukaryotic | Eukaryotes | 27 | 0.32 | Functional ≤ 10μM |
| MCR-2-E | Mineralocorticoid Receptor (cluster #2 Of 2), Eukaryotic | Eukaryotes | 470 | 0.27 | Functional ≤ 10μM |
| PRGR-2-E | Progesterone Receptor (cluster #2 Of 2), Eukaryotic | Eukaryotes | 3 | 0.36 | Functional ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| ANDR_HUMAN | P10275 | Androgen Receptor, Human | 269 | 0.28 | Binding ≤ 1μM |
| ESR1_HUMAN | P03372 | Estrogen Receptor Alpha, Human | 20 | 0.33 | Binding ≤ 1μM |
| ESR2_HUMAN | Q92731 | Estrogen Receptor Beta, Human | 20 | 0.33 | Binding ≤ 1μM |
| GCR_HUMAN | P04150 | Glucocorticoid Receptor, Human | 27 | 0.32 | Binding ≤ 1μM |
| PRGR_HUMAN | P06401 | Progesterone Receptor, Human | 1.6 | 0.37 | Binding ≤ 1μM |
| ANDR_HUMAN | P10275 | Androgen Receptor, Human | 269 | 0.28 | Binding ≤ 10μM |
| ESR1_HUMAN | P03372 | Estrogen Receptor Alpha, Human | 20 | 0.33 | Binding ≤ 10μM |
| ESR2_HUMAN | Q92731 | Estrogen Receptor Beta, Human | 20 | 0.33 | Binding ≤ 10μM |
| GCR_HUMAN | P04150 | Glucocorticoid Receptor, Human | 27 | 0.32 | Binding ≤ 10μM |
| PRGR_HUMAN | P06401 | Progesterone Receptor, Human | 1.6 | 0.37 | Binding ≤ 10μM |
| ANDR_HUMAN | P10275 | Androgen Receptor, Human | 269 | 0.28 | Functional ≤ 10μM |
| GCR_HUMAN | P04150 | Glucocorticoid Receptor, Human | 27 | 0.32 | Functional ≤ 10μM |
| MCR_HUMAN | P08235 | Mineralocorticoid Receptor, Human | 470 | 0.27 | Functional ≤ 10μM |
| PRGR_HUMAN | P06401 | Progesterone Receptor, Human | 1.6 | 0.37 | Functional ≤ 10μM |
| Description | Species |
|---|---|
| BMAL1:CLOCK,NPAS2 activates circadian gene expression | |
| Nuclear Receptor transcription pathway | |
| Nuclear signaling by ERBB4 |
