| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| September 26th, 2005 | 19 | Yes |
Popular Name: 6-(1H-tetrazol-5-ylmethyl)-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic 6-(1H-tetrazol-5-ylmethyl)-1,2,3…
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | -0.99 | -0.5 | -69.33 | 2 | 7 | -1 | 109 | 264.309 | 3 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| NMD3A-2-E | Glutamate [NMDA] Receptor Subunit 3A (cluster #2 Of 6), Eukaryotic | Eukaryotes | 820 | 0.45 | Binding ≤ 10μM |
| NMD3B-2-E | Glutamate [NMDA] Receptor Subunit 3B (cluster #2 Of 6), Eukaryotic | Eukaryotes | 820 | 0.45 | Binding ≤ 10μM |
| NMDE1-4-E | Glutamate [NMDA] Receptor Subunit Epsilon 1 (cluster #4 Of 5), Eukaryotic | Eukaryotes | 820 | 0.45 | Binding ≤ 10μM |
| NMDE2-2-E | Glutamate [NMDA] Receptor Subunit Epsilon 2 (cluster #2 Of 5), Eukaryotic | Eukaryotes | 820 | 0.45 | Binding ≤ 10μM |
| NMDE4-2-E | Glutamate [NMDA] Receptor Subunit Epsilon 4 (cluster #2 Of 6), Eukaryotic | Eukaryotes | 820 | 0.45 | Binding ≤ 10μM |
| NMDZ1-2-E | Glutamate (NMDA) Receptor Subunit Zeta 1 (cluster #2 Of 6), Eukaryotic | Eukaryotes | 820 | 0.45 | Binding ≤ 10μM |
| Z104302-3-O | Glutamate NMDA Receptor (cluster #3 Of 7), Other | Other | 940 | 0.44 | Binding ≤ 10μM |
| Z104302-1-O | Glutamate NMDA Receptor (cluster #1 Of 3), Other | Other | 1400 | 0.43 | Functional ≤ 10μM |
| Z50597-1-O | Rattus Norvegicus (cluster #1 Of 12), Other | Other | 1400 | 0.43 | Functional ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| NMDZ1_RAT | P35439 | Glutamate (NMDA) Receptor Subunit Zeta 1, Rat | 820 | 0.45 | Binding ≤ 1μM |
| Z104302 | Z104302 | Glutamate NMDA Receptor | 940 | 0.44 | Binding ≤ 1μM |
| NMD3A_RAT | Q9R1M7 | Glutamate [NMDA] Receptor Subunit 3A, Rat | 820 | 0.45 | Binding ≤ 1μM |
| NMD3B_RAT | Q8VHN2 | Glutamate [NMDA] Receptor Subunit 3B, Rat | 820 | 0.45 | Binding ≤ 1μM |
| NMDE1_RAT | Q00959 | Glutamate [NMDA] Receptor Subunit Epsilon 1, Rat | 820 | 0.45 | Binding ≤ 1μM |
| NMDE2_RAT | Q00960 | Glutamate [NMDA] Receptor Subunit Epsilon 2, Rat | 820 | 0.45 | Binding ≤ 1μM |
| NMDE4_RAT | Q62645 | Glutamate [NMDA] Receptor Subunit Epsilon 4, Rat | 820 | 0.45 | Binding ≤ 1μM |
| NMDZ1_RAT | P35439 | Glutamate (NMDA) Receptor Subunit Zeta 1, Rat | 820 | 0.45 | Binding ≤ 10μM |
| Z104302 | Z104302 | Glutamate NMDA Receptor | 940 | 0.44 | Binding ≤ 10μM |
| NMD3A_RAT | Q9R1M7 | Glutamate [NMDA] Receptor Subunit 3A, Rat | 820 | 0.45 | Binding ≤ 10μM |
| NMD3B_RAT | Q8VHN2 | Glutamate [NMDA] Receptor Subunit 3B, Rat | 820 | 0.45 | Binding ≤ 10μM |
| NMDE1_RAT | Q00959 | Glutamate [NMDA] Receptor Subunit Epsilon 1, Rat | 820 | 0.45 | Binding ≤ 10μM |
| NMDE2_RAT | Q00960 | Glutamate [NMDA] Receptor Subunit Epsilon 2, Rat | 820 | 0.45 | Binding ≤ 10μM |
| NMDE4_RAT | Q62645 | Glutamate [NMDA] Receptor Subunit Epsilon 4, Rat | 820 | 0.45 | Binding ≤ 10μM |
| Z104302 | Z104302 | Glutamate NMDA Receptor | 1400 | 0.43 | Functional ≤ 10μM |
| Z50597 | Z50597 | Rattus Norvegicus | 1400 | 0.43 | Functional ≤ 10μM |
| Description | Species |
|---|---|
| CREB phosphorylation through the activation of CaMKII | |
| EPHB-mediated forward signaling | |
| Ras activation uopn Ca2+ infux through NMDA receptor | |
| Unblocking of NMDA receptor, glutamate binding and activation |
