| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| October 21st, 2005 | 30 | Yes |
Popular Name: DNC003825 DNC003825
None
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 2.42 | -0.98 | -69.94 | 2 | 5 | 0 | 75 | 402.494 | 8 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| ITA2B-1-E | Integrin Alpha-IIb (cluster #1 Of 1), Eukaryotic | Eukaryotes | 9000 | 0.24 | Binding ≤ 10μM |
| ITAV-1-E | Vitronectin Receptor Alpha (cluster #1 Of 1), Eukaryotic | Eukaryotes | 3 | 0.40 | Binding ≤ 10μM |
| ITB3-1-E | Integrin Beta-3 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 9000 | 0.24 | Binding ≤ 10μM |
| ITB5-1-E | Integrin Beta-5 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 3 | 0.40 | Binding ≤ 10μM |
| Z104292-1-O | Integrin Alpha-V/beta-3 (cluster #1 Of 1), Other | Other | 8 | 0.38 | Binding ≤ 10μM |
| Z104292-1-O | Integrin Alpha-V/beta-3 (cluster #1 Of 1), Other | Other | 60 | 0.34 | Binding ≤ 10μM |
| Z104292-1-O | Integrin Alpha-V/beta-3 (cluster #1 Of 1), Other | Other | 60 | 0.34 | Functional ≤ 10μM |
| Z50587-4-O | Homo Sapiens (cluster #4 Of 9), Other | Other | 48 | 0.34 | Functional ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| Z104292 | Z104292 | Integrin Alpha-V/beta-3 | 4 | 0.39 | Binding ≤ 1μM |
| ITB5_HUMAN | P18084 | Integrin Beta-5, Human | 1.3 | 0.41 | Binding ≤ 1μM |
| ITAV_HUMAN | P06756 | Vitronectin Receptor Alpha, Human | 1.3 | 0.41 | Binding ≤ 1μM |
| ITA2B_HUMAN | P08514 | Integrin Alpha-IIb, Human | 1200 | 0.28 | Binding ≤ 10μM |
| Z104292 | Z104292 | Integrin Alpha-V/beta-3 | 4 | 0.39 | Binding ≤ 10μM |
| ITB3_HUMAN | P05106 | Integrin Beta-3, Human | 1200 | 0.28 | Binding ≤ 10μM |
| ITB5_HUMAN | P18084 | Integrin Beta-5, Human | 1.3 | 0.41 | Binding ≤ 10μM |
| ITAV_HUMAN | P06756 | Vitronectin Receptor Alpha, Human | 1.3 | 0.41 | Binding ≤ 10μM |
| Z50587 | Z50587 | Homo Sapiens | 48 | 0.34 | Functional ≤ 10μM |
| Z104292 | Z104292 | Integrin Alpha-V/beta-3 | 60 | 0.34 | Functional ≤ 10μM |
| Description | Species |
|---|---|
| Cross-presentation of particulate exogenous antigens (phagosomes) | |
| ECM proteoglycans | |
| Elastic fibre formation | |
| GRB2:SOS provides linkage to MAPK signaling for Integrins | |
| Integrin alphaIIb beta3 signaling | |
| Integrin cell surface interactions | |
| Laminin interactions | |
| Molecules associated with elastic fibres | |
| p130Cas linkage to MAPK signaling for integrins | |
| PECAM1 interactions | |
| Platelet degranulation | |
| Signal transduction by L1 | |
| Smooth Muscle Contraction | |
| Syndecan interactions | |
| VEGFA-VEGFR2 Pathway |
