| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| November 7th, 2005 | 26 | Yes |
Popular Name: Protirelin Protirelin
Find On: PubMed — Wikipedia — Google
CAS Numbers: 24305-27-9 , 40216-95-3 , 53935-32-3 , [24305-27-9]
24305-27-9; C03958; Protirelin; TRH; Thyroliberin; Thyrotropin-releasing hormone
53935-32-3; D02007; Hirtonin (TN); Protirelin tartrate hydrate (JP16)
A-38579; ABBOTT-38579; Synthetic Trh
L-Pyroglutamyl-L-histidyl-L-prolinamide
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | -2.03 | 0.18 | -23.59 | 5 | 10 | 0 | 150 | 362.39 | 6 | ↓ |
| Mid Mid (pH 6-8) | -2.03 | 0.01 | -48.98 | 6 | 10 | 1 | 152 | 363.398 | 6 | ↓ |
| Mid Mid (pH 6-8) | -1.91 | -8.71 | -54.13 | 6 | 10 | 1 | 160 | 363.398 | 6 | ↓ |
| Mid Mid (pH 6-8) | -1.91 | -10.03 | -22.33 | 5 | 10 | 0 | 158 | 362.39 | 6 | ↓ |
| Mid Mid (pH 6-8) | -1.91 | -9.27 | -22.9 | 5 | 10 | 0 | 158 | 362.39 | 6 | ↓ |
| Mid Mid (pH 6-8) | -1.91 | -8.91 | -58.35 | 6 | 10 | 1 | 160 | 363.398 | 6 | ↓ |
| Mid Mid (pH 6-8) | -2.03 | -0.51 | -25.71 | 5 | 10 | 0 | 150 | 362.39 | 6 | ↓ |
| Mid Mid (pH 6-8) | -2.03 | 0.02 | -48.79 | 6 | 10 | 1 | 152 | 363.398 | 6 | ↓ |
| Note Type | Comments | Provided By |
|---|---|---|
| UniProt Database Links | AKT1_DROME; IGSF1_MOUSE; PH4H_DICDI; PH4H_DROME; TRFR_BOVIN; TRFR_CHICK; TRFR_HUMAN; TRFR_MOUSE; TRFR_RAT; TRFR_SHEEP; TRHA_XENLA; TRHB_XENLA; TRHDE_HUMAN; TRHDE_MOUSE; TRHDE_RAT; TRH_BOMOR; TRH_CARAU; TRH_CHICK; TRH_CYPCA; TRH_DANRE; TRH_HUMAN; TRH_MOUSE | ChEBI |
| Therapy | prothyrotropin | SMDC Pharmakon |
| Indications | thyrotrophin releasing hormone | KeyOrganics Bioactives |
| Indications | thyrotrophin releasing hormone, epilepsy | KeyOrganics Bioactives |
| Patent Database Links | WO2007125318 | ChEBI |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| Q9R297-1-E | Thyrotropin-releasing Hormone Receptor 2 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 3 | 0.46 | Binding ≤ 10μM |
| TRFR-1-E | Thyrotropin-releasing Hormone Receptor (cluster #1 Of 1), Eukaryotic | Eukaryotes | 3 | 0.46 | Binding ≤ 10μM |
| TRFR-1-E | Thyrotropin-releasing Hormone Receptor (cluster #1 Of 1), Eukaryotic | Eukaryotes | 23 | 0.41 | Binding ≤ 10μM |
| TRFR-1-E | Thyrotropin-releasing Hormone Receptor (cluster #1 Of 1), Eukaryotic | Eukaryotes | 42 | 0.40 | Binding ≤ 10μM |
| Q9R297-1-E | Thyrotropin-releasing Hormone Receptor 2 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 3 | 0.46 | Functional ≤ 10μM |
| TRFR-1-E | Thyrotropin-releasing Hormone Receptor (cluster #1 Of 1), Eukaryotic | Eukaryotes | 3 | 0.46 | Functional ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| TRFR_RAT | Q01717 | Thyrotropin-releasing Hormone Receptor, Rat | 20 | 0.41 | Binding ≤ 1μM |
| TRFR_HUMAN | P34981 | Thyrotropin-releasing Hormone Receptor, Human | 20 | 0.41 | Binding ≤ 1μM |
| TRFR_MOUSE | P21761 | Thyrotropin-releasing Hormone Receptor, Mouse | 0.49 | 0.50 | Binding ≤ 1μM |
| Q9R297_RAT | Q9R297 | Thyrotropin-releasing Hormone Receptor 2, Rat | 10 | 0.43 | Binding ≤ 1μM |
| TRFR_RAT | Q01717 | Thyrotropin-releasing Hormone Receptor, Rat | 20 | 0.41 | Binding ≤ 10μM |
| TRFR_HUMAN | P34981 | Thyrotropin-releasing Hormone Receptor, Human | 20 | 0.41 | Binding ≤ 10μM |
| TRFR_MOUSE | P21761 | Thyrotropin-releasing Hormone Receptor, Mouse | 0.49 | 0.50 | Binding ≤ 10μM |
| Q9R297_RAT | Q9R297 | Thyrotropin-releasing Hormone Receptor 2, Rat | 10 | 0.43 | Binding ≤ 10μM |
| TRFR_HUMAN | P34981 | Thyrotropin-releasing Hormone Receptor, Human | 3 | 0.46 | Functional ≤ 10μM |
| Q9R297_RAT | Q9R297 | Thyrotropin-releasing Hormone Receptor 2, Rat | 3 | 0.46 | Functional ≤ 10μM |
| Description | Species |
|---|---|
| G alpha (q) signalling events | |
| Peptide ligand-binding receptors |
