Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	4.22	12.81	-49.88	2	7	1	71	489.603	4	↓ MOL2 SDF SMILES Flexibase
Hi High (pH 8-9.5)	4.22	10.49	-13.6	1	7	0	70	488.595	4	↓ MOL2 SDF SMILES Flexibase
Lo Low (pH 4.5-6)	4.22	13.27	-87.02	3	7	2	72	490.611	4	↓ MOL2 SDF SMILES Flexibase

Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
BRAF-1-E	Serine/threonine-protein Kinase B-raf (cluster #1 Of 1), Eukaryotic	Eukaryotes	1	0.34	Binding ≤ 10μM
Z103203-1-O	A375 (cluster #1 Of 3), Other	Other	300	0.25	Functional ≤ 10μM
Z80054-1-O	Caco-2 (Colon Adenocarcinoma Cells) (cluster #1 Of 4), Other	Other	1300	0.22	Functional ≤ 10μM
Z80166-1-O	HT-29 (Colon Adenocarcinoma Cells) (cluster #1 Of 12), Other	Other	270	0.25	Functional ≤ 10μM

ChEMBL Target Annotations
Uniprot	Swissprot	Description	Affinity (nM)	LE (kcal/mol/atom)	Type
BRAF_HUMAN	P15056	Serine/threonine-protein Kinase B-raf, Human	0.9	0.34	Binding ≤ 1μM
BRAF_HUMAN	P15056	Serine/threonine-protein Kinase B-raf, Human	0.9	0.34	Binding ≤ 10μM
Z103203	Z103203	A375	300	0.25	Functional ≤ 10μM
Z80054	Z80054	Caco-2 (Colon Adenocarcinoma Cells)	1300	0.22	Functional ≤ 10μM
Z80166	Z80166	HT-29 (Colon Adenocarcinoma Cells)	270	0.25	Functional ≤ 10μM

Description	Species
ARMS-mediated activation	Homo sapiens (BRAF_HUMAN)
CREB phosphorylation through the activation of Ras	Homo sapiens (BRAF_HUMAN)
Frs2-mediated activation	Homo sapiens (BRAF_HUMAN)
Signalling to p38 via RIT and RIN	Homo sapiens (BRAF_HUMAN)
Spry regulation of FGF signaling	Homo sapiens (BRAF_HUMAN)