Physical Representations
Type
pH range
|
xlogP
|
Des A‑Pol
Apolar desolvation
(kcal/mol)
|
Des Pol
Polar desolvation
(kcal/mol)
|
H Don
H-bond donors
|
H Acc
H-bond acceptors
|
Chg
Net charge
|
tPSA
(Ų)
|
MWT
Molecular weight
(g/mol)
|
RB
Rotatable bonds
|
DL |
Ref
Reference (pH 7)
|
-0.15 |
1.39 |
-132.29 |
10 |
12 |
2 |
198 |
595.726 |
11 |
↓
|
Clustered Target Annotations
Code |
Organism Class |
Affinity (nM) |
LE (kcal/mol/atom) |
Type |
FA10-1-E |
Coagulation Factor X (cluster #1 Of 2), Eukaryotic |
Eukaryotes |
2500 |
0.19 |
Binding ≤ 10μM
|
PLMN-2-E |
Plasminogen (cluster #2 Of 2), Eukaryotic |
Eukaryotes |
2500 |
0.19 |
Binding ≤ 10μM
|
ST14-1-E |
Matriptase (cluster #1 Of 1), Eukaryotic |
Eukaryotes |
150 |
0.23 |
Binding ≤ 10μM
|
UROK-2-E |
Urokinase-type Plasminogen Activator (cluster #2 Of 4), Eukaryotic |
Eukaryotes |
8370 |
0.17 |
Binding ≤ 10μM
|
Reactome Annotations from Targets (via Uniprot)
Description |
Species |
Activation of Matrix Metalloproteinases |
|
Common Pathway |
|
Degradation of the extracellular matrix |
|
Dissolution of Fibrin Clot |
|
Extrinsic Pathway |
|
Gamma-carboxylation of protein precursors |
|
Intrinsic Pathway |
|
Platelet degranulation |
|
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l |
|
Removal of aminoterminal propeptides from gamma-carboxylated proteins |
|
Signaling by PDGF |
|
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulu |
|
No pre-computed analogs available. Try a structural similarity search.