| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| July 28th, 2004 | 11 | Yes |
Popular Name: (2S,4R)-4-METHYLGLUTAMIC ACID (2S,4R)-4-METHYLGLUTAMIC ACID
Find On: PubMed — Wikipedia — Google
CAS Numbers: 14561-55-8 , 31137-74-3
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | -2.77 | 2.24 | -66.93 | 3 | 5 | -1 | 108 | 160.149 | 4 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| GRIK1-3-E | Glutamate Receptor Ionotropic Kainate 1 (cluster #3 Of 3), Eukaryotic | Eukaryotes | 3 | 1.08 | Binding ≤ 10μM |
| GRIK2-2-E | Glutamate Receptor Ionotropic Kainate 2 (cluster #2 Of 3), Eukaryotic | Eukaryotes | 10 | 1.02 | Binding ≤ 10μM |
| GRIK3-2-E | Glutamate Receptor Ionotropic Kainate 3 (cluster #2 Of 3), Eukaryotic | Eukaryotes | 6 | 1.05 | Binding ≤ 10μM |
| GRIK4-2-E | Glutamate Receptor Ionotropic Kainate 4 (cluster #2 Of 2), Eukaryotic | Eukaryotes | 35 | 0.95 | Binding ≤ 10μM |
| GRIK5-2-E | Glutamate Receptor Ionotropic Kainate 5 (cluster #2 Of 2), Eukaryotic | Eukaryotes | 35 | 0.95 | Binding ≤ 10μM |
| EAA3-1-E | Excitatory Amino Acid Transporter 3 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 6600 | 0.66 | Functional ≤ 10μM |
| GRM6-1-E | Metabotropic Glutamate Receptor 6 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 4000 | 0.69 | Functional ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| GRIK1_HUMAN | P39086 | Glutamate Receptor Ionotropic Kainate 1, Human | 3 | 1.08 | Binding ≤ 1μM |
| GRIK1_RAT | P22756 | Glutamate Receptor Ionotropic Kainate 1, Rat | 0.660693448 | 1.17 | Binding ≤ 1μM |
| GRIK2_HUMAN | Q13002 | Glutamate Receptor Ionotropic Kainate 2, Human | 10 | 1.02 | Binding ≤ 1μM |
| GRIK2_RAT | P42260 | Glutamate Receptor Ionotropic Kainate 2, Rat | 14.7910839 | 1.00 | Binding ≤ 1μM |
| GRIK3_RAT | P42264 | Glutamate Receptor Ionotropic Kainate 3, Rat | 35 | 0.95 | Binding ≤ 1μM |
| GRIK4_RAT | Q01812 | Glutamate Receptor Ionotropic Kainate 4, Rat | 35 | 0.95 | Binding ≤ 1μM |
| GRIK5_RAT | Q63273 | Glutamate Receptor Ionotropic Kainate 5, Rat | 35 | 0.95 | Binding ≤ 1μM |
| GRIK1_HUMAN | P39086 | Glutamate Receptor Ionotropic Kainate 1, Human | 3 | 1.08 | Binding ≤ 10μM |
| GRIK1_RAT | P22756 | Glutamate Receptor Ionotropic Kainate 1, Rat | 0.660693448 | 1.17 | Binding ≤ 10μM |
| GRIK2_HUMAN | Q13002 | Glutamate Receptor Ionotropic Kainate 2, Human | 10 | 1.02 | Binding ≤ 10μM |
| GRIK2_RAT | P42260 | Glutamate Receptor Ionotropic Kainate 2, Rat | 14.7910839 | 1.00 | Binding ≤ 10μM |
| GRIK3_RAT | P42264 | Glutamate Receptor Ionotropic Kainate 3, Rat | 35 | 0.95 | Binding ≤ 10μM |
| GRIK4_RAT | Q01812 | Glutamate Receptor Ionotropic Kainate 4, Rat | 35 | 0.95 | Binding ≤ 10μM |
| GRIK5_RAT | Q63273 | Glutamate Receptor Ionotropic Kainate 5, Rat | 35 | 0.95 | Binding ≤ 10μM |
| EAA3_HUMAN | P43005 | Excitatory Amino Acid Transporter 3, Human | 6600 | 0.66 | Functional ≤ 10μM |
| GRM6_HUMAN | O15303 | Metabotropic Glutamate Receptor 6, Human | 4000 | 0.69 | Functional ≤ 10μM |
| Description | Species |
|---|---|
| Activation of Ca-permeable Kainate Receptor | |
| Activation of Na-permeable Kainate Receptors | |
| Class C/3 (Metabotropic glutamate/pheromone receptors) | |
| G alpha (i) signalling events | |
| Glutamate Neurotransmitter Release Cycle | |
| Transport of inorganic cations/anions and amino acids/oligopeptides |
