UCSF

Fibroblast Growth Factor Receptor 4, Mouse (22 Compounds)

Swissprot:
FGFR4_MOUSE
Stitch:
FGFR4_MOUSE
UniProt:
Q03142
ChEMBL:
CHEMBL3839
Reactome:
REACT_199063
REACT_196588
REACT_206694
REACT_234357
REACT_198525
REACT_230708
REACT_223993
REACT_240139
REACT_226341
REACT_94437
REACT_196455
REACT_196510
PDB:
Fgfr4

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 22 1 0 0
Binding ≤ 1μM 11 1 0 0
Functional ≤ 10μM 5 0 0 0

Reactome Network (12)

Reactome ID Description Species
REACT_199063 betaKlotho-mediated ligand binding Mus musculus
REACT_196588 Constitutive PI3K/AKT Signaling in Cancer Mus musculus
REACT_206694 FGFR4 ligand binding and activation Mus musculus
REACT_234357 FRS2-mediated cascade Mus musculus
REACT_198525 Negative regulation of FGFR signaling Mus musculus
REACT_230708 Phospholipase C-mediated cascade Mus musculus
REACT_223993 PI-3K cascade Mus musculus
REACT_240139 PI3K Cascade Mus musculus
REACT_226341 PIP3 activates AKT signaling Mus musculus
REACT_94437 SHC-mediated cascade Mus musculus
REACT_196455 Signaling by FGFR mutants Mus musculus
REACT_196510 Signaling by FGFR4 mutants Mus musculus
Uniprot Swissprot Chembl Description Number Shared
FGFR1_MOUSE P16092 CHEMBL3960 Fibroblast Growth Factor Receptor 1, Mouse 27
PGFRA_MOUSE P26618 CHEMBL3466 Platelet-derived Growth Factor Receptor Alpha, Mouse 21

FRS2-mediated cascade

Uniprot Swissprot Chembl Description Number Shared
FGFR1_MOUSE P16092 CHEMBL3960 Fibroblast Growth Factor Receptor 1, Mouse 27

Negative regulation of FGFR signaling

Uniprot Swissprot Chembl Description Number Shared
FGFR1_MOUSE P16092 CHEMBL3960 Fibroblast Growth Factor Receptor 1, Mouse 27

Phospholipase C-mediated cascade

Uniprot Swissprot Chembl Description Number Shared
FGFR1_MOUSE P16092 CHEMBL3960 Fibroblast Growth Factor Receptor 1, Mouse 27

PI-3K cascade

Uniprot Swissprot Chembl Description Number Shared
FGFR1_MOUSE P16092 CHEMBL3960 Fibroblast Growth Factor Receptor 1, Mouse 27

PI3K Cascade

Uniprot Swissprot Chembl Description Number Shared
FGFR1_MOUSE P16092 CHEMBL3960 Fibroblast Growth Factor Receptor 1, Mouse 27

PIP3 activates AKT signaling

Uniprot Swissprot Chembl Description Number Shared
FGFR1_MOUSE P16092 CHEMBL3960 Fibroblast Growth Factor Receptor 1, Mouse 27
PGFRA_MOUSE P26618 CHEMBL3466 Platelet-derived Growth Factor Receptor Alpha, Mouse 21

SHC-mediated cascade

Uniprot Swissprot Chembl Description Number Shared
FGFR1_MOUSE P16092 CHEMBL3960 Fibroblast Growth Factor Receptor 1, Mouse 27

Signaling by FGFR mutants

Uniprot Swissprot Chembl Description Number Shared
FGFR1_MOUSE P16092 CHEMBL3960 Fibroblast Growth Factor Receptor 1, Mouse 27
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
FGFR4_HUMAN P22455 CHEMBL3973 Fibroblast Growth Factor Receptor 4, Human 62 13 3 6
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
FGFR1_MOUSE P16092 CHEMBL3960 Fibroblast Growth Factor Receptor 1, Mouse 30 4 0 2
FGFR2_MOUSE P21803 CHEMBL3648 Fibroblast Growth Factor Receptor 2, Mouse 22 1 0 0
FGFR3_MOUSE Q61851 CHEMBL4066 Fibroblast Growth Factor Receptor 3, Mouse 22 1 0 0

Clustered By Gene (0)

Uniprot Swissprot Chembl Description Number Shared
FGFR1_MOUSE P16092 CHEMBL3960 Fibroblast Growth Factor Receptor 1, Mouse 27
FGFR2_MOUSE P21803 CHEMBL3648 Fibroblast Growth Factor Receptor 2, Mouse 27
FGFR3_MOUSE Q61851 CHEMBL4066 Fibroblast Growth Factor Receptor 3, Mouse 27
PGFRB_MOUSE P05622 CHEMBL2749 Platelet-derived Growth Factor Receptor Beta, Mouse 24
PGFRA_MOUSE P26618 CHEMBL3466 Platelet-derived Growth Factor Receptor Alpha, Mouse 21
SRC_MOUSE P05480 CHEMBL3074 Tyrosine-protein Kinase SRC, Mouse 21
PGFRA_RAT P20786 CHEMBL2513 Platelet-derived Growth Factor Receptor Alpha, Rat 5
PGFRB_RAT Q05030 CHEMBL4125 Platelet-derived Growth Factor Receptor Beta, Rat 5
FGFR1_HUMAN P11362 CHEMBL3650 Fibroblast Growth Factor Receptor 1, Human 4
SRC_CHICK P00523 CHEMBL3655 Tyrosine-protein Kinase SRC, Chick 3
Z80005 Z80005 CHEMBL614077 3T3 (Fibroblast Cells) 3
Z80530 Z80530 CHEMBL614946 Swiss-3T3 (Fibroblast Cells) 3
EGFR_HUMAN P00533 CHEMBL203 Epidermal Growth Factor Receptor ErbB1, Human 2
FGFR2_HUMAN P21802 CHEMBL4142 Fibroblast Growth Factor Receptor 2, Human 2
FGFR3_HUMAN P22607 CHEMBL2742 Fibroblast Growth Factor Receptor 3, Human 2
FGFR4_HUMAN P22455 CHEMBL3973 Fibroblast Growth Factor Receptor 4, Human 2
SRC_HUMAN P12931 CHEMBL267 Tyrosine-protein Kinase SRC, Human 2
CSK_MOUSE P41241 CHEMBL2333 Tyrosine-protein Kinase CSK, Mouse 1
WEE1_HUMAN P30291 CHEMBL5491 Serine/threonine-protein Kinase WEE1, Human 1