|
Analogs
Draw
Identity
99%
90%
80%
70%
Vendors
And 19 More
Clustered Target Annotations
Code |
Organism Class |
Affinity (nM) |
LE (kcal/mol/atom) |
Type |
GRM4-3-E |
Metabotropic Glutamate Receptor 4 (cluster #3 Of 3), Eukaryotic |
Eukaryotes |
1300 |
0.75 |
Binding ≤ 10μM
|
GRM6-1-E |
Metabotropic Glutamate Receptor 6 (cluster #1 Of 1), Eukaryotic |
Eukaryotes |
2700 |
0.71 |
Binding ≤ 10μM
|
Physical Representations
Type
pH range
|
xlogP
|
Des A‑Pol
Apolar desolvation
(kcal/mol)
|
Des Pol
Polar desolvation
(kcal/mol)
|
H Don
H-bond donors
|
H Acc
H-bond acceptors
|
Chg
Net charge
|
tPSA
(Ų)
|
MWT
Molecular weight
(g/mol)
|
RB
Rotatable bonds
|
DL |
Ref
Reference (pH 7)
|
-4.29 |
-1.1 |
-142.53 |
3 |
7 |
-2 |
140 |
183.056 |
4 |
↓
|
Lo
Low (pH 4.5-6)
|
-4.29 |
-2.27 |
-64.66 |
4 |
7 |
-1 |
137 |
184.064 |
4 |
↓
|
|
|
Analogs
-
39268864
-
-
39268865
-
Draw
Identity
99%
90%
80%
70%
Vendors
And 10 More
Clustered Target Annotations
Code |
Organism Class |
Affinity (nM) |
LE (kcal/mol/atom) |
Type |
GRM4-3-E |
Metabotropic Glutamate Receptor 4 (cluster #3 Of 3), Eukaryotic |
Eukaryotes |
330 |
0.82 |
Binding ≤ 10μM
|
GRM4-3-E |
Metabotropic Glutamate Receptor 4 (cluster #3 Of 3), Eukaryotic |
Eukaryotes |
500 |
0.80 |
Binding ≤ 10μM
|
GRM6-1-E |
Metabotropic Glutamate Receptor 6 (cluster #1 Of 1), Eukaryotic |
Eukaryotes |
280 |
0.83 |
Binding ≤ 10μM
|
GRM6-1-E |
Metabotropic Glutamate Receptor 6 (cluster #1 Of 1), Eukaryotic |
Eukaryotes |
900 |
0.77 |
Binding ≤ 10μM
|
GRM8-1-E |
Metabotropic Glutamate Receptor 8 (cluster #1 Of 2), Eukaryotic |
Eukaryotes |
5 |
1.06 |
Binding ≤ 10μM
|
GRM8-1-E |
Metabotropic Glutamate Receptor 8 (cluster #1 Of 2), Eukaryotic |
Eukaryotes |
1900 |
0.73 |
Binding ≤ 10μM
|
GRM4-1-E |
Metabotropic Glutamate Receptor 4 (cluster #1 Of 1), Eukaryotic |
Eukaryotes |
910 |
0.77 |
Functional ≤ 10μM
|
GRM6-1-E |
Metabotropic Glutamate Receptor 6 (cluster #1 Of 2), Eukaryotic |
Eukaryotes |
55 |
0.92 |
Functional ≤ 10μM
|
GRM6-1-E |
Metabotropic Glutamate Receptor 6 (cluster #1 Of 2), Eukaryotic |
Eukaryotes |
1000 |
0.76 |
Functional ≤ 10μM |
GRM8-2-E |
Metabotropic Glutamate Receptor 8 (cluster #2 Of 2), Eukaryotic |
Eukaryotes |
60 |
0.92 |
Functional ≤ 10μM
|
Z50597-3-O |
Rattus Norvegicus (cluster #3 Of 5), Other |
Other |
1500 |
0.74 |
Binding ≤ 10μM
|
Z50597-2-O |
Rattus Norvegicus (cluster #2 Of 12), Other |
Other |
2500 |
0.71 |
Functional ≤ 10μM
|
Physical Representations
Type
pH range
|
xlogP
|
Des A‑Pol
Apolar desolvation
(kcal/mol)
|
Des Pol
Polar desolvation
(kcal/mol)
|
H Don
H-bond donors
|
H Acc
H-bond acceptors
|
Chg
Net charge
|
tPSA
(Ų)
|
MWT
Molecular weight
(g/mol)
|
RB
Rotatable bonds
|
DL |
Ref
Reference (pH 7)
|
-4.02 |
-1.71 |
-66.95 |
4 |
6 |
-1 |
128 |
182.092 |
4 |
↓
|
|
|
Analogs
Draw
Identity
99%
90%
80%
70%
Vendors
And 4 More
Clustered Target Annotations
Code |
Organism Class |
Affinity (nM) |
LE (kcal/mol/atom) |
Type |
GRM5-4-E |
Metabotropic Glutamate Receptor 5 (cluster #4 Of 5), Eukaryotic |
Eukaryotes |
6490 |
0.61 |
Binding ≤ 10μM
|
GRM6-1-E |
Metabotropic Glutamate Receptor 6 (cluster #1 Of 1), Eukaryotic |
Eukaryotes |
6490 |
0.61 |
Binding ≤ 10μM
|
GRM7-1-E |
Metabotropic Glutamate Receptor 7 (cluster #1 Of 1), Eukaryotic |
Eukaryotes |
6490 |
0.61 |
Binding ≤ 10μM
|
GRM8-1-E |
Metabotropic Glutamate Receptor 8 (cluster #1 Of 2), Eukaryotic |
Eukaryotes |
6490 |
0.61 |
Binding ≤ 10μM
|
GRM2-1-E |
Metabotropic Glutamate Receptor 2 (cluster #1 Of 2), Eukaryotic |
Eukaryotes |
450 |
0.74 |
Functional ≤ 10μM
|
GRM3-1-E |
Metabotropic Glutamate Receptor 3 (cluster #1 Of 2), Eukaryotic |
Eukaryotes |
410 |
0.75 |
Functional ≤ 10μM
|
Physical Representations
Type
pH range
|
xlogP
|
Des A‑Pol
Apolar desolvation
(kcal/mol)
|
Des Pol
Polar desolvation
(kcal/mol)
|
H Don
H-bond donors
|
H Acc
H-bond acceptors
|
Chg
Net charge
|
tPSA
(Ų)
|
MWT
Molecular weight
(g/mol)
|
RB
Rotatable bonds
|
DL |
Ref
Reference (pH 7)
|
-4.82 |
-0.09 |
-57.41 |
4 |
6 |
-1 |
123 |
173.148 |
2 |
↓
|
Hi
High (pH 8-9.5)
|
-4.82 |
-1.49 |
-97.56 |
3 |
6 |
-2 |
118 |
172.14 |
2 |
↓
|
|
|
Analogs
Draw
Identity
99%
90%
80%
70%
Vendors
Clustered Target Annotations
Code |
Organism Class |
Affinity (nM) |
LE (kcal/mol/atom) |
Type |
GRM1-1-E |
Metabotropic Glutamate Receptor 1 (cluster #1 Of 3), Eukaryotic |
Eukaryotes |
8990 |
0.27 |
Binding ≤ 10μM
|
GRM2-1-E |
Metabotropic Glutamate Receptor 2 (cluster #1 Of 2), Eukaryotic |
Eukaryotes |
200 |
0.36 |
Binding ≤ 10μM
|
GRM3-1-E |
Metabotropic Glutamate Receptor 3 (cluster #1 Of 1), Eukaryotic |
Eukaryotes |
3 |
0.46 |
Binding ≤ 10μM
|
GRM4-2-E |
Metabotropic Glutamate Receptor 4 (cluster #2 Of 3), Eukaryotic |
Eukaryotes |
2650 |
0.30 |
Binding ≤ 10μM
|
GRM6-1-E |
Metabotropic Glutamate Receptor 6 (cluster #1 Of 1), Eukaryotic |
Eukaryotes |
1140 |
0.32 |
Binding ≤ 10μM
|
GRM7-1-E |
Metabotropic Glutamate Receptor 7 (cluster #1 Of 1), Eukaryotic |
Eukaryotes |
110 |
0.37 |
Binding ≤ 10μM
|
GRM1-4-E |
Metabotropic Glutamate Receptor 1 (cluster #4 Of 5), Eukaryotic |
Eukaryotes |
7800 |
0.28 |
Functional ≤ 10μM
|
GRM2-2-E |
Metabotropic Glutamate Receptor 2 (cluster #2 Of 2), Eukaryotic |
Eukaryotes |
23 |
0.41 |
Functional ≤ 10μM
|
GRM3-1-E |
Metabotropic Glutamate Receptor 3 (cluster #1 Of 2), Eukaryotic |
Eukaryotes |
14 |
0.42 |
Functional ≤ 10μM
|
GRM5-2-E |
Metabotropic Glutamate Receptor 5 (cluster #2 Of 5), Eukaryotic |
Eukaryotes |
8200 |
0.27 |
Functional ≤ 10μM
|
GRM7-2-E |
Metabotropic Glutamate Receptor 7 (cluster #2 Of 2), Eukaryotic |
Eukaryotes |
990 |
0.32 |
Functional ≤ 10μM
|
GRM8-1-E |
Metabotropic Glutamate Receptor 8 (cluster #1 Of 2), Eukaryotic |
Eukaryotes |
170 |
0.36 |
Functional ≤ 10μM
|
Z50597-1-O |
Rattus Norvegicus (cluster #1 Of 5), Other |
Other |
10 |
0.43 |
Binding ≤ 10μM
|
Physical Representations
Type
pH range
|
xlogP
|
Des A‑Pol
Apolar desolvation
(kcal/mol)
|
Des Pol
Polar desolvation
(kcal/mol)
|
H Don
H-bond donors
|
H Acc
H-bond acceptors
|
Chg
Net charge
|
tPSA
(Ų)
|
MWT
Molecular weight
(g/mol)
|
RB
Rotatable bonds
|
DL |
Ref
Reference (pH 7)
|
0.75 |
10.29 |
-80.49 |
3 |
6 |
-1 |
117 |
352.366 |
5 |
↓
|
|
|
Analogs
Draw
Identity
99%
90%
80%
70%
Vendors
And 145 More
Clustered Target Annotations
Code |
Organism Class |
Affinity (nM) |
LE (kcal/mol/atom) |
Type |
AA3R-6-E |
Adenosine Receptor A3 (cluster #6 Of 6), Eukaryotic |
Eukaryotes |
613 |
0.87 |
Binding ≤ 10μM
|
EAA3-2-E |
Excitatory Amino Acid Transporter 3 (cluster #2 Of 2), Eukaryotic |
Eukaryotes |
51 |
1.02 |
Binding ≤ 10μM
|
GRIA1-3-E |
Glutamate Receptor Ionotropic, AMPA 1 (cluster #3 Of 4), Eukaryotic |
Eukaryotes |
1360 |
0.82 |
Binding ≤ 10μM
|
GRIA2-3-E |
Glutamate Receptor Ionotropic, AMPA 2 (cluster #3 Of 4), Eukaryotic |
Eukaryotes |
940 |
0.84 |
Binding ≤ 10μM
|
GRIA3-3-E |
Glutamate Receptor Ionotropic, AMPA 3 (cluster #3 Of 4), Eukaryotic |
Eukaryotes |
500 |
0.88 |
Binding ≤ 10μM
|
GRIA4-3-E |
Glutamate Receptor Ionotropic, AMPA 4 (cluster #3 Of 5), Eukaryotic |
Eukaryotes |
868 |
0.85 |
Binding ≤ 10μM
|
GRIK1-3-E |
Glutamate Receptor Ionotropic Kainate 1 (cluster #3 Of 3), Eukaryotic |
Eukaryotes |
701 |
0.86 |
Binding ≤ 10μM
|
GRIK2-2-E |
Glutamate Receptor Ionotropic Kainate 2 (cluster #2 Of 3), Eukaryotic |
Eukaryotes |
1106 |
0.83 |
Binding ≤ 10μM
|
GRIK3-2-E |
Glutamate Receptor Ionotropic Kainate 3 (cluster #2 Of 3), Eukaryotic |
Eukaryotes |
789 |
0.85 |
Binding ≤ 10μM
|
GRIK4-2-E |
Glutamate Receptor Ionotropic Kainate 4 (cluster #2 Of 2), Eukaryotic |
Eukaryotes |
700 |
0.86 |
Binding ≤ 10μM
|
GRIK5-2-E |
Glutamate Receptor Ionotropic Kainate 5 (cluster #2 Of 2), Eukaryotic |
Eukaryotes |
700 |
0.86 |
Binding ≤ 10μM
|
GRM1-3-E |
Metabotropic Glutamate Receptor 1 (cluster #3 Of 3), Eukaryotic |
Eukaryotes |
570 |
0.87 |
Binding ≤ 10μM
|
GRM2-1-E |
Metabotropic Glutamate Receptor 2 (cluster #1 Of 2), Eukaryotic |
Eukaryotes |
7400 |
0.72 |
Binding ≤ 10μM
|
GRM3-1-E |
Metabotropic Glutamate Receptor 3 (cluster #1 Of 1), Eukaryotic |
Eukaryotes |
3000 |
0.77 |
Binding ≤ 10μM
|
GRM4-3-E |
Metabotropic Glutamate Receptor 4 (cluster #3 Of 3), Eukaryotic |
Eukaryotes |
2400 |
0.79 |
Binding ≤ 10μM
|
GRM5-4-E |
Metabotropic Glutamate Receptor 5 (cluster #4 Of 5), Eukaryotic |
Eukaryotes |
4100 |
0.75 |
Binding ≤ 10μM
|
GRM6-1-E |
Metabotropic Glutamate Receptor 6 (cluster #1 Of 1), Eukaryotic |
Eukaryotes |
7600 |
0.72 |
Binding ≤ 10μM
|
GRM8-1-E |
Metabotropic Glutamate Receptor 8 (cluster #1 Of 2), Eukaryotic |
Eukaryotes |
3400 |
0.77 |
Binding ≤ 10μM
|
NMDZ1-4-E |
Glutamate (NMDA) Receptor Subunit Zeta 1 (cluster #4 Of 6), Eukaryotic |
Eukaryotes |
450 |
0.89 |
Binding ≤ 10μM
|
GRIA1-3-E |
Glutamate Receptor Ionotropic, AMPA 1 (cluster #3 Of 3), Eukaryotic |
Eukaryotes |
6160 |
0.73 |
Functional ≤ 10μM
|
GRIA2-3-E |
Glutamate Receptor Ionotropic, AMPA 2 (cluster #3 Of 4), Eukaryotic |
Eukaryotes |
6200 |
0.73 |
Functional ≤ 10μM
|
GRIA3-2-E |
Glutamate Receptor Ionotropic, AMPA 3 (cluster #2 Of 2), Eukaryotic |
Eukaryotes |
3660 |
0.76 |
Functional ≤ 10μM
|
GRM1-4-E |
Metabotropic Glutamate Receptor 1 (cluster #4 Of 5), Eukaryotic |
Eukaryotes |
10000 |
0.70 |
Functional ≤ 10μM
|
GRM2-1-E |
Metabotropic Glutamate Receptor 2 (cluster #1 Of 2), Eukaryotic |
Eukaryotes |
8500 |
0.71 |
Functional ≤ 10μM
|
GRM3-1-E |
Metabotropic Glutamate Receptor 3 (cluster #1 Of 2), Eukaryotic |
Eukaryotes |
9000 |
0.71 |
Functional ≤ 10μM
|
GRM4-1-E |
Metabotropic Glutamate Receptor 4 (cluster #1 Of 1), Eukaryotic |
Eukaryotes |
6100 |
0.73 |
Functional ≤ 10μM
|
GRM5-5-E |
Metabotropic Glutamate Receptor 5 (cluster #5 Of 5), Eukaryotic |
Eukaryotes |
4900 |
0.74 |
Functional ≤ 10μM
|
GRM6-1-E |
Metabotropic Glutamate Receptor 6 (cluster #1 Of 2), Eukaryotic |
Eukaryotes |
7600 |
0.72 |
Functional ≤ 10μM
|
GRM8-1-E |
Metabotropic Glutamate Receptor 8 (cluster #1 Of 2), Eukaryotic |
Eukaryotes |
9500 |
0.70 |
Functional ≤ 10μM
|
NMDE1-1-E |
Glutamate [NMDA] Receptor Subunit Epsilon 1 (cluster #1 Of 2), Eukaryotic |
Eukaryotes |
1800 |
0.80 |
Functional ≤ 10μM
|
NMDZ1-1-E |
Glutamate (NMDA) Receptor Subunit Zeta 1 (cluster #1 Of 3), Eukaryotic |
Eukaryotes |
1800 |
0.80 |
Functional ≤ 10μM
|
Z104302-3-O |
Glutamate NMDA Receptor (cluster #3 Of 7), Other |
Other |
870 |
0.85 |
Binding ≤ 10μM
|
Z50597-3-O |
Rattus Norvegicus (cluster #3 Of 5), Other |
Other |
170 |
0.95 |
Binding ≤ 10μM
|
Z50597-7-O |
Rattus Norvegicus (cluster #7 Of 12), Other |
Other |
1300 |
0.82 |
Functional ≤ 10μM
|
Physical Representations
Type
pH range
|
xlogP
|
Des A‑Pol
Apolar desolvation
(kcal/mol)
|
Des Pol
Polar desolvation
(kcal/mol)
|
H Don
H-bond donors
|
H Acc
H-bond acceptors
|
Chg
Net charge
|
tPSA
(Ų)
|
MWT
Molecular weight
(g/mol)
|
RB
Rotatable bonds
|
DL |
Ref
Reference (pH 7)
|
-3.25 |
1.74 |
-73.91 |
3 |
5 |
-1 |
108 |
146.122 |
4 |
↓
|
|
|
Analogs
Draw
Identity
99%
90%
80%
70%
Vendors
And 1 More
Clustered Target Annotations
Code |
Organism Class |
Affinity (nM) |
LE (kcal/mol/atom) |
Type |
GRM4-1-E |
Metabotropic Glutamate Receptor 4 (cluster #1 Of 1), Eukaryotic |
Eukaryotes |
8800 |
0.42 |
Functional ≤ 10μM
|
GRM6-2-E |
Metabotropic Glutamate Receptor 6 (cluster #2 Of 2), Eukaryotic |
Eukaryotes |
3600 |
0.45 |
Functional ≤ 10μM
|
GRM8-2-E |
Metabotropic Glutamate Receptor 8 (cluster #2 Of 2), Eukaryotic |
Eukaryotes |
31 |
0.62 |
Functional ≤ 10μM
|
Physical Representations
Type
pH range
|
xlogP
|
Des A‑Pol
Apolar desolvation
(kcal/mol)
|
Des Pol
Polar desolvation
(kcal/mol)
|
H Don
H-bond donors
|
H Acc
H-bond acceptors
|
Chg
Net charge
|
tPSA
(Ų)
|
MWT
Molecular weight
(g/mol)
|
RB
Rotatable bonds
|
DL |
Ref
Reference (pH 7)
|
-2.25 |
-2.79 |
-173.92 |
3 |
7 |
-2 |
148 |
237.167 |
4 |
↓
|
|
|
Analogs
-
3995880
-
Draw
Identity
99%
90%
80%
70%
Vendors
And 1 More
Clustered Target Annotations
Code |
Organism Class |
Affinity (nM) |
LE (kcal/mol/atom) |
Type |
GRM4-3-E |
Metabotropic Glutamate Receptor 4 (cluster #3 Of 3), Eukaryotic |
Eukaryotes |
4700 |
0.50 |
Binding ≤ 10μM
|
GRM4-1-E |
Metabotropic Glutamate Receptor 4 (cluster #1 Of 1), Eukaryotic |
Eukaryotes |
5200 |
0.49 |
Functional ≤ 10μM
|
GRM6-1-E |
Metabotropic Glutamate Receptor 6 (cluster #1 Of 2), Eukaryotic |
Eukaryotes |
4700 |
0.50 |
Functional ≤ 10μM
|
GRM8-2-E |
Metabotropic Glutamate Receptor 8 (cluster #2 Of 2), Eukaryotic |
Eukaryotes |
210 |
0.62 |
Functional ≤ 10μM
|
Physical Representations
Type
pH range
|
xlogP
|
Des A‑Pol
Apolar desolvation
(kcal/mol)
|
Des Pol
Polar desolvation
(kcal/mol)
|
H Don
H-bond donors
|
H Acc
H-bond acceptors
|
Chg
Net charge
|
tPSA
(Ų)
|
MWT
Molecular weight
(g/mol)
|
RB
Rotatable bonds
|
DL |
Ref
Reference (pH 7)
|
-2.51 |
1.54 |
-162.59 |
3 |
6 |
-2 |
131 |
229.128 |
3 |
↓
|
|
|
Analogs
-
1997134
-
Draw
Identity
99%
90%
80%
70%
Vendors
And 1 More
Clustered Target Annotations
Code |
Organism Class |
Affinity (nM) |
LE (kcal/mol/atom) |
Type |
GRM4-3-E |
Metabotropic Glutamate Receptor 4 (cluster #3 Of 3), Eukaryotic |
Eukaryotes |
4700 |
0.50 |
Binding ≤ 10μM
|
GRM4-1-E |
Metabotropic Glutamate Receptor 4 (cluster #1 Of 1), Eukaryotic |
Eukaryotes |
5200 |
0.49 |
Functional ≤ 10μM
|
GRM6-1-E |
Metabotropic Glutamate Receptor 6 (cluster #1 Of 2), Eukaryotic |
Eukaryotes |
4700 |
0.50 |
Functional ≤ 10μM
|
GRM8-2-E |
Metabotropic Glutamate Receptor 8 (cluster #2 Of 2), Eukaryotic |
Eukaryotes |
210 |
0.62 |
Functional ≤ 10μM
|
Physical Representations
Type
pH range
|
xlogP
|
Des A‑Pol
Apolar desolvation
(kcal/mol)
|
Des Pol
Polar desolvation
(kcal/mol)
|
H Don
H-bond donors
|
H Acc
H-bond acceptors
|
Chg
Net charge
|
tPSA
(Ų)
|
MWT
Molecular weight
(g/mol)
|
RB
Rotatable bonds
|
DL |
Ref
Reference (pH 7)
|
-2.51 |
1.55 |
-163.03 |
3 |
6 |
-2 |
131 |
229.128 |
3 |
↓
|
Mid
Mid (pH 6-8)
|
-2.51 |
0.44 |
-76.52 |
4 |
6 |
-1 |
128 |
230.136 |
3 |
↓
|
|
|
Analogs
Draw
Identity
99%
90%
80%
70%
Vendors
Physical Representations
Type
pH range
|
xlogP
|
Des A‑Pol
Apolar desolvation
(kcal/mol)
|
Des Pol
Polar desolvation
(kcal/mol)
|
H Don
H-bond donors
|
H Acc
H-bond acceptors
|
Chg
Net charge
|
tPSA
(Ų)
|
MWT
Molecular weight
(g/mol)
|
RB
Rotatable bonds
|
DL |
Ref
Reference (pH 7)
|
-2.69 |
2.22 |
-74.96 |
3 |
5 |
-1 |
108 |
158.133 |
3 |
↓
|
|
|
Analogs
-
39268864
-
-
39268865
-
Draw
Identity
99%
90%
80%
70%
Vendors
And 10 More
Clustered Target Annotations
Code |
Organism Class |
Affinity (nM) |
LE (kcal/mol/atom) |
Type |
GRM4-3-E |
Metabotropic Glutamate Receptor 4 (cluster #3 Of 3), Eukaryotic |
Eukaryotes |
330 |
0.82 |
Binding ≤ 10μM
|
GRM6-1-E |
Metabotropic Glutamate Receptor 6 (cluster #1 Of 1), Eukaryotic |
Eukaryotes |
280 |
0.83 |
Binding ≤ 10μM
|
GRM8-1-E |
Metabotropic Glutamate Receptor 8 (cluster #1 Of 2), Eukaryotic |
Eukaryotes |
5 |
1.06 |
Binding ≤ 10μM
|
GRM6-1-E |
Metabotropic Glutamate Receptor 6 (cluster #1 Of 2), Eukaryotic |
Eukaryotes |
1000 |
0.76 |
Functional ≤ 10μM |
Physical Representations
Type
pH range
|
xlogP
|
Des A‑Pol
Apolar desolvation
(kcal/mol)
|
Des Pol
Polar desolvation
(kcal/mol)
|
H Don
H-bond donors
|
H Acc
H-bond acceptors
|
Chg
Net charge
|
tPSA
(Ų)
|
MWT
Molecular weight
(g/mol)
|
RB
Rotatable bonds
|
DL |
Ref
Reference (pH 7)
|
-4.02 |
-1.72 |
-66.73 |
4 |
6 |
-1 |
128 |
182.092 |
4 |
↓
|
|