Note Type	Comments	Provided By
UniProt Database Links	050L_FRG3G; 089R_FRG3G; 1A110_ARATH; 22K_ADES1; 254L_IIV6; 2SS_SOYBN; 33K_ADES1; 348R_IIV6; 3BP5L_BOVIN; 3BP5L_HUMAN; 3BP5L_MOUSE; 3BP5L_PONAB; 3BP5_HUMAN; 3BP5_MOUSE; 3BP5_RAT; AAAT_MOUSE; AAC4_DICDI; AACL_AGRT5; AADAT_BOVIN; AADAT_HUMAN; AADAT_MOUSE; AA	ChEBI
SOLUBILITY	1 M HCl: 100 mg/mL	Indofine
Melting_Point	115-118?	Alfa-Aesar
Melting_Point	115-118°	Alfa-Aesar
Melting_Point	189-192? dec.	Alfa-Aesar
Melting_Point	189-192° dec.	Alfa-Aesar
Mp [°C]	194	Acros Organics
MP	199°(dec.)	Oakwood Chemical
Melting_Point	203? dec.	Alfa-Aesar
Melting_Point	203° dec.	Alfa-Aesar
MP	205 °C (dec.)(lit.)	Indofine
Melting_Point	228? dec.	Alfa-Aesar
Melting_Point	228° dec.	Alfa-Aesar
UniProt Database Links	3HAPM_CUPPJ; A16A1_BOVIN; A16A1_HUMAN; A16A1_MOUSE; A16A1_RAT; AAAT_MOUSE; AACL_AGRT5; AADAT_BOVIN; AADAT_HUMAN; AADAT_MOUSE; AADAT_RAT; AAP1_ARATH; AAP2_ARATH; AAP5_ARATH; AAP8_ARATH; AASS_ARATH; AASS_BOVIN; AASS_HUMAN; AASS_MOUSE; AASS_RAT; AAT1_ARATH	ChEBI
ALOGPS_SOLUBILITY	8.06e+01 g/l	DrugBank-experimental
BP	94-97°/3mm	Oakwood Chemical
Purity	95%	Fluorochem
Purity	97%	APIChem
Purity	98%	Fluorochem
Melting_Point	ca 200? dec.	Alfa-Aesar
Melting_Point	ca 200° dec.	Alfa-Aesar
UniProt Database Links	CITE2_HUMAN; CITE2_MOUSE; GNAT3_BOVIN; GNAT3_HUMAN; GNAT3_MOUSE; GNAT3_RAT; MASZ_ECOLI; SER1_GALME; SER2_GALME; SERI1_BOMMO; SERO_GALME; TS1R1_HUMAN; TS1R1_MOUSE; TS1R1_RAT; TS1R3_CANFA; TS1R3_FELCA; TS1R3_GORGO; TS1R3_HUMAN; TS1R3_MOUSE; TS1R3_PANTR; TS1	ChEBI
UniProt Database Links	CSPG4_HUMAN; CSPG4_MOUSE; CSPG4_RAT; ENOA_BOVIN; ENOA_HUMAN; ENOA_MACFA; ENOA_MESAU; ENOA_MOUSE; ENOA_PONAB; ENOA_RAT; ENOB_MOUSE; HRG_BOVIN; HRG_HUMAN; HRG_MOUSE; HRG_RABIT; HRG_RAT; PDGFC_HUMAN; PDGFC_MOUSE; PDGFC_RAT; PLMN_BOVIN; PLMN_CANFA; PLMN_CAPHI	ChEBI
PUBCHEM_PATENT_ID	EP0019081A1; US4352792	IBM Patent Data
Patent Database Links	EP1127869; EP1291342; EP1422218; EP1541585; EP1568283; EP1609462; EP1616963; EP1627884; EP1632233; EP1714677; EP1745791; EP1752189; EP1762232; EP1849466; EP1867657; EP1958965; EP1967186; EP1983044; GB2096992; US2002159961; US2003049284; US2003125517; US20	ChEBI
Notes	Ph.Eur, Pyrogen free	Apollo Scientific Bioactives
Reactome Database Links	REACT_11083; REACT_11098; REACT_111140; REACT_111222; REACT_11134; REACT_11135; REACT_1136; REACT_116056; REACT_1171; REACT_12411; REACT_12503; REACT_12617; REACT_13574; REACT_13588; REACT_14; REACT_1427; REACT_14830; REACT_150192; REACT_15291; REACT_1532	ChEBI
S phrase	S24/25: Avoid contact with skin and eyes.	Acros Organics

Activity (Go SEA)

Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
AA3R-6-E	Adenosine Receptor A3 (cluster #6 Of 6), Eukaryotic	Eukaryotes	613	0.87	Binding ≤ 10μM
EAA3-2-E	Excitatory Amino Acid Transporter 3 (cluster #2 Of 2), Eukaryotic	Eukaryotes	51	1.02	Binding ≤ 10μM
GRIA1-3-E	Glutamate Receptor Ionotropic, AMPA 1 (cluster #3 Of 4), Eukaryotic	Eukaryotes	1360	0.82	Binding ≤ 10μM
GRIA2-3-E	Glutamate Receptor Ionotropic, AMPA 2 (cluster #3 Of 4), Eukaryotic	Eukaryotes	940	0.84	Binding ≤ 10μM
GRIA3-3-E	Glutamate Receptor Ionotropic, AMPA 3 (cluster #3 Of 4), Eukaryotic	Eukaryotes	500	0.88	Binding ≤ 10μM
GRIA4-3-E	Glutamate Receptor Ionotropic, AMPA 4 (cluster #3 Of 5), Eukaryotic	Eukaryotes	868	0.85	Binding ≤ 10μM
GRIK1-3-E	Glutamate Receptor Ionotropic Kainate 1 (cluster #3 Of 3), Eukaryotic	Eukaryotes	701	0.86	Binding ≤ 10μM
GRIK2-2-E	Glutamate Receptor Ionotropic Kainate 2 (cluster #2 Of 3), Eukaryotic	Eukaryotes	1106	0.83	Binding ≤ 10μM
GRIK3-2-E	Glutamate Receptor Ionotropic Kainate 3 (cluster #2 Of 3), Eukaryotic	Eukaryotes	789	0.85	Binding ≤ 10μM
GRIK4-2-E	Glutamate Receptor Ionotropic Kainate 4 (cluster #2 Of 2), Eukaryotic	Eukaryotes	700	0.86	Binding ≤ 10μM
GRIK5-2-E	Glutamate Receptor Ionotropic Kainate 5 (cluster #2 Of 2), Eukaryotic	Eukaryotes	700	0.86	Binding ≤ 10μM
GRM1-3-E	Metabotropic Glutamate Receptor 1 (cluster #3 Of 3), Eukaryotic	Eukaryotes	570	0.87	Binding ≤ 10μM
GRM2-1-E	Metabotropic Glutamate Receptor 2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	7400	0.72	Binding ≤ 10μM
GRM3-1-E	Metabotropic Glutamate Receptor 3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	3000	0.77	Binding ≤ 10μM
GRM4-3-E	Metabotropic Glutamate Receptor 4 (cluster #3 Of 3), Eukaryotic	Eukaryotes	2400	0.79	Binding ≤ 10μM
GRM5-4-E	Metabotropic Glutamate Receptor 5 (cluster #4 Of 5), Eukaryotic	Eukaryotes	4100	0.75	Binding ≤ 10μM
GRM6-1-E	Metabotropic Glutamate Receptor 6 (cluster #1 Of 1), Eukaryotic	Eukaryotes	7600	0.72	Binding ≤ 10μM
GRM8-1-E	Metabotropic Glutamate Receptor 8 (cluster #1 Of 2), Eukaryotic	Eukaryotes	3400	0.77	Binding ≤ 10μM
NMDZ1-4-E	Glutamate (NMDA) Receptor Subunit Zeta 1 (cluster #4 Of 6), Eukaryotic	Eukaryotes	450	0.89	Binding ≤ 10μM
GRIA1-3-E	Glutamate Receptor Ionotropic, AMPA 1 (cluster #3 Of 3), Eukaryotic	Eukaryotes	6160	0.73	Functional ≤ 10μM
GRIA2-3-E	Glutamate Receptor Ionotropic, AMPA 2 (cluster #3 Of 4), Eukaryotic	Eukaryotes	6200	0.73	Functional ≤ 10μM
GRIA3-2-E	Glutamate Receptor Ionotropic, AMPA 3 (cluster #2 Of 2), Eukaryotic	Eukaryotes	3660	0.76	Functional ≤ 10μM
GRM1-4-E	Metabotropic Glutamate Receptor 1 (cluster #4 Of 5), Eukaryotic	Eukaryotes	10000	0.70	Functional ≤ 10μM
GRM2-1-E	Metabotropic Glutamate Receptor 2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	8500	0.71	Functional ≤ 10μM
GRM3-1-E	Metabotropic Glutamate Receptor 3 (cluster #1 Of 2), Eukaryotic	Eukaryotes	9000	0.71	Functional ≤ 10μM
GRM4-1-E	Metabotropic Glutamate Receptor 4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	6100	0.73	Functional ≤ 10μM
GRM5-5-E	Metabotropic Glutamate Receptor 5 (cluster #5 Of 5), Eukaryotic	Eukaryotes	4900	0.74	Functional ≤ 10μM
GRM6-1-E	Metabotropic Glutamate Receptor 6 (cluster #1 Of 2), Eukaryotic	Eukaryotes	7600	0.72	Functional ≤ 10μM
GRM8-1-E	Metabotropic Glutamate Receptor 8 (cluster #1 Of 2), Eukaryotic	Eukaryotes	9500	0.70	Functional ≤ 10μM
NMDE1-1-E	Glutamate [NMDA] Receptor Subunit Epsilon 1 (cluster #1 Of 2), Eukaryotic	Eukaryotes	1800	0.80	Functional ≤ 10μM
NMDZ1-1-E	Glutamate (NMDA) Receptor Subunit Zeta 1 (cluster #1 Of 3), Eukaryotic	Eukaryotes	1800	0.80	Functional ≤ 10μM
Z104302-3-O	Glutamate NMDA Receptor (cluster #3 Of 7), Other	Other	870	0.85	Binding ≤ 10μM
Z50597-3-O	Rattus Norvegicus (cluster #3 Of 5), Other	Other	170	0.95	Binding ≤ 10μM
Z50597-7-O	Rattus Norvegicus (cluster #7 Of 12), Other	Other	1300	0.82	Functional ≤ 10μM

ChEMBL Target Annotations
Uniprot	Swissprot	Description	Affinity (nM)	LE (kcal/mol/atom)	Type
AA3R_HUMAN	P33765	Adenosine A3 Receptor, Human	613	0.87	Binding ≤ 1μM
EAA3_HUMAN	P43005	Excitatory Amino Acid Transporter 3, Human	51	1.02	Binding ≤ 1μM
NMDZ1_RAT	P35439	Glutamate (NMDA) Receptor Subunit Zeta 1, Rat	1000	0.84	Binding ≤ 1μM
Z104302	Z104302	Glutamate NMDA Receptor	1000	0.84	Binding ≤ 1μM
GRIK1_RAT	P22756	Glutamate Receptor Ionotropic Kainate 1, Rat	138.038426	0.96	Binding ≤ 1μM
GRIK1_HUMAN	P39086	Glutamate Receptor Ionotropic Kainate 1, Human	701	0.86	Binding ≤ 1μM
GRIK2_RAT	P42260	Glutamate Receptor Ionotropic Kainate 2, Rat	270	0.92	Binding ≤ 1μM
GRIK3_RAT	P42264	Glutamate Receptor Ionotropic Kainate 3, Rat	270	0.92	Binding ≤ 1μM
GRIK3_HUMAN	Q13003	Glutamate Receptor Ionotropic Kainate 3, Human	789	0.85	Binding ≤ 1μM
GRIK4_RAT	Q01812	Glutamate Receptor Ionotropic Kainate 4, Rat	270	0.92	Binding ≤ 1μM
GRIK5_RAT	Q63273	Glutamate Receptor Ionotropic Kainate 5, Rat	270	0.92	Binding ≤ 1μM
GRIK5_HUMAN	Q16478	Glutamate Receptor Ionotropic Kainate 5, Human	701	0.86	Binding ≤ 1μM
GRIA1_RAT	P19490	Glutamate Receptor Ionotropic, AMPA 1, Rat	169	0.95	Binding ≤ 1μM
GRIA2_RAT	P19491	Glutamate Receptor Ionotropic, AMPA 2, Rat	280	0.92	Binding ≤ 1μM
GRIA2_HUMAN	P42262	Glutamate Receptor Ionotropic, AMPA 2, Human	940	0.84	Binding ≤ 1μM
GRIA3_RAT	P19492	Glutamate Receptor Ionotropic, AMPA 3, Rat	249	0.92	Binding ≤ 1μM
GRIA4_HUMAN	P48058	Glutamate Receptor Ionotropic, AMPA 4, Human	868	0.85	Binding ≤ 1μM
GRIA4_RAT	P19493	Glutamate Receptor Ionotropic, AMPA 4, Rat	354	0.90	Binding ≤ 1μM
GRM1_HUMAN	Q13255	Metabotropic Glutamate Receptor 1, Human	250	0.92	Binding ≤ 1μM
GRM5_HUMAN	P41594	Metabotropic Glutamate Receptor 5, Human	390	0.90	Binding ≤ 1μM
GRM8_MOUSE	P47743	Metabotropic Glutamate Receptor 8, Mouse	22	1.07	Binding ≤ 1μM
GRM8_HUMAN	O00222	Metabotropic Glutamate Receptor 8, Human	5.7	1.15	Binding ≤ 1μM
Z50597	Z50597	Rattus Norvegicus	170	0.95	Binding ≤ 1μM
AA3R_HUMAN	P33765	Adenosine A3 Receptor, Human	613	0.87	Binding ≤ 10μM
EAA3_HUMAN	P43005	Excitatory Amino Acid Transporter 3, Human	51	1.02	Binding ≤ 10μM
NMDZ1_RAT	P35439	Glutamate (NMDA) Receptor Subunit Zeta 1, Rat	1000	0.84	Binding ≤ 10μM
Z104302	Z104302	Glutamate NMDA Receptor	1000	0.84	Binding ≤ 10μM
GRIK1_RAT	P22756	Glutamate Receptor Ionotropic Kainate 1, Rat	138.038426	0.96	Binding ≤ 10μM
GRIK1_HUMAN	P39086	Glutamate Receptor Ionotropic Kainate 1, Human	701	0.86	Binding ≤ 10μM
GRIK2_RAT	P42260	Glutamate Receptor Ionotropic Kainate 2, Rat	270	0.92	Binding ≤ 10μM
GRIK2_HUMAN	Q13002	Glutamate Receptor Ionotropic Kainate 2, Human	1106	0.83	Binding ≤ 10μM
GRIK3_HUMAN	Q13003	Glutamate Receptor Ionotropic Kainate 3, Human	789	0.85	Binding ≤ 10μM
GRIK3_RAT	P42264	Glutamate Receptor Ionotropic Kainate 3, Rat	270	0.92	Binding ≤ 10μM
GRIK4_RAT	Q01812	Glutamate Receptor Ionotropic Kainate 4, Rat	270	0.92	Binding ≤ 10μM
GRIK5_RAT	Q63273	Glutamate Receptor Ionotropic Kainate 5, Rat	270	0.92	Binding ≤ 10μM
GRIK5_HUMAN	Q16478	Glutamate Receptor Ionotropic Kainate 5, Human	701	0.86	Binding ≤ 10μM
GRIA1_HUMAN	P42261	Glutamate Receptor Ionotropic, AMPA 1, Human	1360	0.82	Binding ≤ 10μM
GRIA1_MOUSE	P23818	Glutamate Receptor Ionotropic, AMPA 1, Mouse	1100	0.83	Binding ≤ 10μM
GRIA1_RAT	P19490	Glutamate Receptor Ionotropic, AMPA 1, Rat	169	0.95	Binding ≤ 10μM
GRIA2_RAT	P19491	Glutamate Receptor Ionotropic, AMPA 2, Rat	1100	0.83	Binding ≤ 10μM
GRIA2_HUMAN	P42262	Glutamate Receptor Ionotropic, AMPA 2, Human	940	0.84	Binding ≤ 10μM
GRIA3_RAT	P19492	Glutamate Receptor Ionotropic, AMPA 3, Rat	1100	0.83	Binding ≤ 10μM
GRIA4_RAT	P19493	Glutamate Receptor Ionotropic, AMPA 4, Rat	1100	0.83	Binding ≤ 10μM
GRIA4_HUMAN	P48058	Glutamate Receptor Ionotropic, AMPA 4, Human	868	0.85	Binding ≤ 10μM
GRM1_HUMAN	Q13255	Metabotropic Glutamate Receptor 1, Human	250	0.92	Binding ≤ 10μM
GRM1_RAT	P23385	Metabotropic Glutamate Receptor 1, Rat	7300	0.72	Binding ≤ 10μM
GRM2_RAT	P31421	Metabotropic Glutamate Receptor 2, Rat	4000	0.76	Binding ≤ 10μM
GRM2_HUMAN	Q14416	Metabotropic Glutamate Receptor 2, Human	4700	0.75	Binding ≤ 10μM
GRM3_RAT	P31422	Metabotropic Glutamate Receptor 3, Rat	3000	0.77	Binding ≤ 10μM
GRM4_RAT	P31423	Metabotropic Glutamate Receptor 4, Rat	3200	0.77	Binding ≤ 10μM
GRM4_HUMAN	Q14833	Metabotropic Glutamate Receptor 4, Human	1400	0.82	Binding ≤ 10μM
GRM5_HUMAN	P41594	Metabotropic Glutamate Receptor 5, Human	1160	0.83	Binding ≤ 10μM
GRM5_RAT	P31424	Metabotropic Glutamate Receptor 5, Rat	10000	0.70	Binding ≤ 10μM
GRM6_RAT	P35349	Metabotropic Glutamate Receptor 6, Rat	7600	0.72	Binding ≤ 10μM
GRM8_RAT	P70579	Metabotropic Glutamate Receptor 8, Rat	3400	0.77	Binding ≤ 10μM
GRM8_MOUSE	P47743	Metabotropic Glutamate Receptor 8, Mouse	22	1.07	Binding ≤ 10μM
GRM8_HUMAN	O00222	Metabotropic Glutamate Receptor 8, Human	5.7	1.15	Binding ≤ 10μM
Z50597	Z50597	Rattus Norvegicus	170	0.95	Binding ≤ 10μM
NMDZ1_RAT	P35439	Glutamate (NMDA) Receptor Subunit Zeta 1, Rat	1800	0.80	Functional ≤ 10μM
GRIA1_RAT	P19490	Glutamate Receptor Ionotropic, AMPA 1, Rat	6400	0.73	Functional ≤ 10μM
GRIA1_HUMAN	P42261	Glutamate Receptor Ionotropic, AMPA 1, Human	2260	0.79	Functional ≤ 10μM
GRIA2_HUMAN	P42262	Glutamate Receptor Ionotropic, AMPA 2, Human	2190	0.79	Functional ≤ 10μM
GRIA3_RAT	P19492	Glutamate Receptor Ionotropic, AMPA 3, Rat	1300	0.82	Functional ≤ 10μM
GRIA3_HUMAN	P42263	Glutamate Receptor Ionotropic, AMPA 3, Human	3660	0.76	Functional ≤ 10μM
NMDE1_RAT	Q00959	Glutamate [NMDA] Receptor Subunit Epsilon 1, Rat	1800	0.80	Functional ≤ 10μM
GRM1_HUMAN	Q13255	Metabotropic Glutamate Receptor 1, Human	10000	0.70	Functional ≤ 10μM
GRM1_RAT	P23385	Metabotropic Glutamate Receptor 1, Rat	4900	0.74	Functional ≤ 10μM
GRM2_HUMAN	Q14416	Metabotropic Glutamate Receptor 2, Human	8500	0.71	Functional ≤ 10μM
GRM2_RAT	P31421	Metabotropic Glutamate Receptor 2, Rat	290	0.92	Functional ≤ 10μM
GRM3_HUMAN	Q14832	Metabotropic Glutamate Receptor 3, Human	2500	0.78	Functional ≤ 10μM
GRM3_RAT	P31422	Metabotropic Glutamate Receptor 3, Rat	290	0.92	Functional ≤ 10μM
GRM4_RAT	P31423	Metabotropic Glutamate Receptor 4, Rat	6100	0.73	Functional ≤ 10μM
GRM5_RAT	P31424	Metabotropic Glutamate Receptor 5, Rat	1200	0.83	Functional ≤ 10μM
GRM6_RAT	P35349	Metabotropic Glutamate Receptor 6, Rat	7600	0.72	Functional ≤ 10μM
GRM8_HUMAN	O00222	Metabotropic Glutamate Receptor 8, Human	9500	0.70	Functional ≤ 10μM
Z50597	Z50597	Rattus Norvegicus	1300	0.82	Functional ≤ 10μM

Direct Reactome Annotations (via ChEBI)

Description	Species
Activation of AMPA receptors	Sus scrofa Homo sapiens Gallus gallus Mus musculus Taeniopygia guttata Canis familiaris Danio rerio Rattus norvegicus Drosophila melanogaster Caenorhabditis elegans Xenopus tropicalis Bos taurus
Activation of Ca-permeable Kainate Receptor	Mus musculus Homo sapiens Caenorhabditis elegans Canis familiaris Taeniopygia guttata Gallus gallus Xenopus tropicalis Danio rerio Drosophila melanogaster Bos taurus Rattus norvegicus Sus scrofa
Activation of Na-permeable Kainate Receptors	Xenopus tropicalis Gallus gallus Bos taurus Taeniopygia guttata Mus musculus Sus scrofa Rattus norvegicus Homo sapiens Drosophila melanogaster Canis familiaris Caenorhabditis elegans Danio rerio
Aflatoxin activation and detoxification	Xenopus tropicalis Danio rerio Rattus norvegicus Canis familiaris Mus musculus Taeniopygia guttata Schizosaccharomyces pombe Arabidopsis thaliana Drosophila melanogaster Bos taurus Caenorhabditis elegans Saccharomyces cerevisiae Oryza sativa Homo sapiens Sus scrofa Gallus gallus
Amino acid metabolism	Gallus gallus
Amino acid synthesis and interconversion (transamination)	Danio rerio Dictyostelium discoideum Arabidopsis thaliana Plasmodium falciparum Drosophila melanogaster Bos taurus Canis familiaris Mus musculus Gallus gallus Homo sapiens Saccharomyces cerevisiae Rattus norvegicus Sus scrofa Oryza sativa Taeniopygia guttata Schizosaccharomyces pombe Caenorhabditis elegans Xenopus tropicalis
Amino acid transport across the plasma membrane	Xenopus tropicalis Rattus norvegicus Canis familiaris Bos taurus Sus scrofa Drosophila melanogaster Homo sapiens Danio rerio Mus musculus
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	Homo sapiens Oryza sativa Canis familiaris Xenopus tropicalis Bos taurus Gallus gallus Caenorhabditis elegans Danio rerio Rattus norvegicus Mus musculus Sus scrofa Dictyostelium discoideum Drosophila melanogaster
Antigen processing: Ubiquitination & Proteasome degradation	Bos taurus Drosophila melanogaster Mus musculus Taeniopygia guttata Schizosaccharomyces pombe Canis familiaris Saccharomyces cerevisiae Oryza sativa Homo sapiens Gallus gallus Danio rerio Xenopus tropicalis Sus scrofa Dictyostelium discoideum Rattus norvegicus Arabidopsis thaliana Plasmodium falciparum Caenorhabditis elegans
Astrocytic Glutamate-Glutamine Uptake And Metabolism	Bos taurus Gallus gallus Rattus norvegicus Schizosaccharomyces pombe Xenopus tropicalis Saccharomyces cerevisiae Homo sapiens Sus scrofa Danio rerio Taeniopygia guttata Canis familiaris Drosophila melanogaster Mus musculus Caenorhabditis elegans Oryza sativa Arabidopsis thaliana
Branched-chain amino acid catabolism	Bos taurus Caenorhabditis elegans Sus scrofa Homo sapiens Saccharomyces cerevisiae Gallus gallus Xenopus tropicalis Oryza sativa Taeniopygia guttata Rattus norvegicus Mus musculus Dictyostelium discoideum Schizosaccharomyces pombe Drosophila melanogaster Canis familiaris Arabidopsis thaliana Danio rerio
Class C/3 (Metabotropic glutamate/pheromone receptors)	Mus musculus Canis familiaris Taeniopygia guttata Sus scrofa Caenorhabditis elegans Bos taurus Danio rerio Gallus gallus Xenopus tropicalis Rattus norvegicus Homo sapiens Drosophila melanogaster
CREB phosphorylation through the activation of CaMKII	Sus scrofa Rattus norvegicus Mus musculus Xenopus tropicalis Danio rerio Gallus gallus Canis familiaris Caenorhabditis elegans Bos taurus Drosophila melanogaster Taeniopygia guttata Homo sapiens
Cross-presentation of soluble exogenous antigens (endosomes)	Schizosaccharomyces pombe Drosophila melanogaster Homo sapiens Dictyostelium discoideum Danio rerio Arabidopsis thaliana Plasmodium falciparum Mus musculus Oryza sativa Taeniopygia guttata Rattus norvegicus Sus scrofa Canis familiaris Caenorhabditis elegans Saccharomyces cerevisiae Gallus gallus Bos taurus Xenopus tropicalis
Cytosolic tRNA aminoacylation	Plasmodium falciparum Gallus gallus Drosophila melanogaster Dictyostelium discoideum Arabidopsis thaliana Xenopus tropicalis Danio rerio Mus musculus Bos taurus Oryza sativa Canis familiaris Homo sapiens Sus scrofa Rattus norvegicus Taeniopygia guttata
De novo synthesis of GMP	Gallus gallus
De novo synthesis of IMP	Gallus gallus
De novo synthesis of UMP	Gallus gallus
Degradation of GABA	Bos taurus Dictyostelium discoideum Sus scrofa Rattus norvegicus Xenopus tropicalis Canis familiaris Oryza sativa Homo sapiens Danio rerio Schizosaccharomyces pombe Mus musculus Drosophila melanogaster Caenorhabditis elegans Gallus gallus Arabidopsis thaliana Taeniopygia guttata Saccharomyces cerevisiae
Endosomal/Vacuolar pathway	Sus scrofa Canis familiaris Gallus gallus Rattus norvegicus Caenorhabditis elegans Xenopus tropicalis Taeniopygia guttata Bos taurus Dictyostelium discoideum Danio rerio Drosophila melanogaster Mus musculus Homo sapiens
EPHB-mediated forward signaling	Xenopus tropicalis Mus musculus Danio rerio Caenorhabditis elegans Rattus norvegicus Gallus gallus Sus scrofa Canis familiaris Taeniopygia guttata Drosophila melanogaster Homo sapiens Bos taurus
ER-Phagosome pathway	Bos taurus Drosophila melanogaster Taeniopygia guttata Plasmodium falciparum Caenorhabditis elegans Gallus gallus Oryza sativa Danio rerio Arabidopsis thaliana Dictyostelium discoideum Canis familiaris Saccharomyces cerevisiae Mus musculus Sus scrofa Xenopus tropicalis Homo sapiens Schizosaccharomyces pombe Rattus norvegicus
G alpha (i) signalling events	Caenorhabditis elegans Drosophila melanogaster Sus scrofa Homo sapiens Bos taurus Taeniopygia guttata Canis familiaris Mus musculus Gallus gallus Rattus norvegicus Danio rerio Xenopus tropicalis
G alpha (q) signalling events	Homo sapiens Danio rerio Xenopus tropicalis Taeniopygia guttata Canis familiaris Rattus norvegicus Mus musculus Sus scrofa Gallus gallus Bos taurus
GABA synthesis	Taeniopygia guttata Gallus gallus Homo sapiens Xenopus tropicalis Canis familiaris Rattus norvegicus Mus musculus Sus scrofa Caenorhabditis elegans Bos taurus Danio rerio Drosophila melanogaster
Gluconeogenesis	Gallus gallus Schizosaccharomyces pombe Danio rerio Sus scrofa Bos taurus Caenorhabditis elegans Taeniopygia guttata Oryza sativa Xenopus tropicalis Drosophila melanogaster Homo sapiens Canis familiaris Mus musculus Dictyostelium discoideum Arabidopsis thaliana Gallus gallus Saccharomyces cerevisiae Plasmodium falciparum Rattus norvegicus
Glutamate Neurotransmitter Release Cycle	Taeniopygia guttata Sus scrofa Drosophila melanogaster Dictyostelium discoideum Caenorhabditis elegans Homo sapiens Rattus norvegicus Canis familiaris Mus musculus Danio rerio Xenopus tropicalis Bos taurus Gallus gallus
Glutathione synthesis and recycling	Drosophila melanogaster Dictyostelium discoideum Sus scrofa Mus musculus Oryza sativa Danio rerio Homo sapiens Rattus norvegicus Canis familiaris Saccharomyces cerevisiae Taeniopygia guttata Caenorhabditis elegans Arabidopsis thaliana Bos taurus Schizosaccharomyces pombe Gallus gallus Xenopus tropicalis
Histidine catabolism	Gallus gallus Xenopus tropicalis Danio rerio Bos taurus Canis familiaris Dictyostelium discoideum Mus musculus Rattus norvegicus Homo sapiens Sus scrofa Taeniopygia guttata
Lysine catabolism	Oryza sativa Rattus norvegicus Schizosaccharomyces pombe Danio rerio Gallus gallus Homo sapiens Mus musculus Bos taurus Dictyostelium discoideum Canis familiaris Caenorhabditis elegans Taeniopygia guttata Sus scrofa Xenopus tropicalis Arabidopsis thaliana Saccharomyces cerevisiae Drosophila melanogaster
Metabolism of folate and pterines	Xenopus tropicalis Mus musculus Plasmodium falciparum Homo sapiens Gallus gallus Bos taurus Danio rerio Oryza sativa Rattus norvegicus Canis familiaris Dictyostelium discoideum Arabidopsis thaliana Sus scrofa Saccharomyces cerevisiae Drosophila melanogaster Caenorhabditis elegans Taeniopygia guttata Schizosaccharomyces pombe
Mitochondrial tRNA aminoacylation	Arabidopsis thaliana Schizosaccharomyces pombe Caenorhabditis elegans Bos taurus Gallus gallus Dictyostelium discoideum Saccharomyces cerevisiae Plasmodium falciparum Xenopus tropicalis Danio rerio Homo sapiens Sus scrofa Mus musculus Rattus norvegicus Oryza sativa Drosophila melanogaster Canis familiaris Taeniopygia guttata
Nicotinate metabolism	Bos taurus Xenopus tropicalis Sus scrofa Mus musculus Danio rerio Canis familiaris Saccharomyces cerevisiae Gallus gallus Dictyostelium discoideum Oryza sativa Caenorhabditis elegans Taeniopygia guttata Arabidopsis thaliana Drosophila melanogaster Plasmodium falciparum Rattus norvegicus Schizosaccharomyces pombe Homo sapiens
Organic anion transporters	Mus musculus Taeniopygia guttata Sus scrofa Gallus gallus Caenorhabditis elegans Rattus norvegicus Bos taurus Homo sapiens Drosophila melanogaster Danio rerio Canis familiaris Xenopus tropicalis
Phenylalanine and tyrosine catabolism	Bos taurus Rattus norvegicus Gallus gallus Mus musculus Homo sapiens Arabidopsis thaliana Danio rerio Dictyostelium discoideum Sus scrofa Oryza sativa Canis familiaris Caenorhabditis elegans Drosophila melanogaster Taeniopygia guttata Xenopus tropicalis
Presynaptic function of Kainate receptors	Danio rerio Mus musculus Bos taurus Xenopus tropicalis Drosophila melanogaster Rattus norvegicus Homo sapiens Caenorhabditis elegans Canis familiaris Taeniopygia guttata Sus scrofa Gallus gallus
Proline catabolism	Danio rerio Xenopus tropicalis Canis familiaris Drosophila melanogaster Caenorhabditis elegans Homo sapiens Oryza sativa Rattus norvegicus Schizosaccharomyces pombe Sus scrofa Gallus gallus Mus musculus Bos taurus Saccharomyces cerevisiae Dictyostelium discoideum Taeniopygia guttata
Proton/oligonucleotide cotransporters	Rattus norvegicus Gallus gallus Canis familiaris Danio rerio Drosophila melanogaster Bos taurus Oryza sativa Caenorhabditis elegans Xenopus tropicalis Dictyostelium discoideum Homo sapiens Arabidopsis thaliana Taeniopygia guttata Mus musculus Sus scrofa
Purine ribonucleoside monophosphate biosynthesis	Canis familiaris Dictyostelium discoideum Danio rerio Gallus gallus Oryza sativa Schizosaccharomyces pombe Sus scrofa Rattus norvegicus Drosophila melanogaster Caenorhabditis elegans Mus musculus Bos taurus Arabidopsis thaliana Taeniopygia guttata Plasmodium falciparum Xenopus tropicalis Saccharomyces cerevisiae Homo sapiens
Pyrimidine biosynthesis	Caenorhabditis elegans Mus musculus Saccharomyces cerevisiae Gallus gallus Sus scrofa Xenopus tropicalis Homo sapiens Danio rerio Drosophila melanogaster Canis familiaris Plasmodium falciparum Schizosaccharomyces pombe Arabidopsis thaliana Rattus norvegicus Bos taurus Dictyostelium discoideum Taeniopygia guttata
Ras activation uopn Ca2+ infux through NMDA receptor	Mus musculus Taeniopygia guttata Sus scrofa Bos taurus Danio rerio Homo sapiens Gallus gallus Canis familiaris Xenopus tropicalis Rattus norvegicus
Serine biosynthesis	Drosophila melanogaster Caenorhabditis elegans Arabidopsis thaliana Canis familiaris Sus scrofa Homo sapiens Oryza sativa Dictyostelium discoideum Rattus norvegicus Saccharomyces cerevisiae Danio rerio Schizosaccharomyces pombe Taeniopygia guttata Xenopus tropicalis Mus musculus Gallus gallus Bos taurus
Sulfur amino acid metabolism	Homo sapiens Caenorhabditis elegans Rattus norvegicus Taeniopygia guttata Xenopus tropicalis Gallus gallus Drosophila melanogaster Bos taurus Sus scrofa Danio rerio Schizosaccharomyces pombe Mus musculus Canis familiaris
Synthesis and interconversion of nucleotide di- and triphosphates	Drosophila melanogaster Arabidopsis thaliana Rattus norvegicus Xenopus tropicalis Sus scrofa Saccharomyces cerevisiae Canis familiaris Caenorhabditis elegans Homo sapiens Dictyostelium discoideum Taeniopygia guttata Mus musculus Schizosaccharomyces pombe Danio rerio Bos taurus Plasmodium falciparum Oryza sativa Gallus gallus
Synthesis of Leukotrienes (LT) and Eoxins (EX)	Drosophila melanogaster Homo sapiens Gallus gallus Schizosaccharomyces pombe Arabidopsis thaliana Saccharomyces cerevisiae Sus scrofa Xenopus tropicalis Bos taurus Mus musculus Taeniopygia guttata Canis familiaris Caenorhabditis elegans Danio rerio Oryza sativa Rattus norvegicus
Synthesis of UDP-N-acetyl-glucosamine	Oryza sativa Homo sapiens Caenorhabditis elegans Taeniopygia guttata Xenopus tropicalis Drosophila melanogaster Gallus gallus Canis familiaris Danio rerio Saccharomyces cerevisiae Bos taurus Schizosaccharomyces pombe Arabidopsis thaliana Sus scrofa Plasmodium falciparum Dictyostelium discoideum Rattus norvegicus Mus musculus
Transport of inorganic cations/anions and amino acids/oligopeptides	Caenorhabditis elegans Mus musculus Canis familiaris Homo sapiens Sus scrofa Gallus gallus Rattus norvegicus Xenopus tropicalis Drosophila melanogaster Taeniopygia guttata Bos taurus Danio rerio
Tryptophan catabolism	Homo sapiens Drosophila melanogaster Mus musculus Canis familiaris Bos taurus Rattus norvegicus Taeniopygia guttata Sus scrofa Schizosaccharomyces pombe Dictyostelium discoideum Xenopus tropicalis Gallus gallus Danio rerio Saccharomyces cerevisiae
Unblocking of NMDA receptor, glutamate binding and activation	Homo sapiens Mus musculus Rattus norvegicus Bos taurus Canis familiaris Taeniopygia guttata Gallus gallus Caenorhabditis elegans Drosophila melanogaster Sus scrofa Xenopus tropicalis Danio rerio
Urea cycle	Sus scrofa Saccharomyces cerevisiae Canis familiaris Xenopus tropicalis Rattus norvegicus Danio rerio Homo sapiens Dictyostelium discoideum Mus musculus Schizosaccharomyces pombe Bos taurus

Reactome Annotations from Targets (via Uniprot)

Description	Species
Activation of AMPA receptors	Homo sapiens (GRIA1_HUMAN) Mus musculus (GRIA1_MOUSE)
Activation of Ca-permeable Kainate Receptor	Rattus norvegicus (GRIK1_RAT) Homo sapiens (GRIK1_HUMAN)
Activation of Na-permeable Kainate Receptors	Homo sapiens (GRIK1_HUMAN) Rattus norvegicus (GRIK1_RAT)
Adenosine P1 receptors	Homo sapiens (AA3R_HUMAN)
Class C/3 (Metabotropic glutamate/pheromone receptors)	Homo sapiens (GRM8_HUMAN) Rattus norvegicus (GRM2_RAT) Mus musculus (GRM8_MOUSE)
CREB phosphorylation through the activation of CaMKII	Rattus norvegicus (NMDZ1_RAT)
EPHB-mediated forward signaling	Rattus norvegicus (NMDZ1_RAT)
G alpha (i) signalling events	Mus musculus (GRM8_MOUSE) Homo sapiens (GRM8_HUMAN) Rattus norvegicus (GRM2_RAT)
G alpha (q) signalling events	Rattus norvegicus (GRM5_RAT) Homo sapiens (GRM5_HUMAN)
Glutamate Neurotransmitter Release Cycle	Homo sapiens (EAA3_HUMAN)
Presynaptic function of Kainate receptors	Homo sapiens (GRIK3_HUMAN)
Ras activation uopn Ca2+ infux through NMDA receptor	Rattus norvegicus (NMDZ1_RAT)
Trafficking of AMPA receptors	Homo sapiens (GRIA1_HUMAN)
Trafficking of GluR2-containing AMPA receptors	Mus musculus (GRIA1_MOUSE) Homo sapiens (GRIA1_HUMAN)
Transport of inorganic cations/anions and amino acids/oligopeptides	Homo sapiens (EAA3_HUMAN)
Unblocking of NMDA receptor, glutamate binding and activation	Mus musculus (GRIA1_MOUSE) Rattus norvegicus (NMDZ1_RAT) Homo sapiens (GRIA1_HUMAN)

Analogs ( Draw Identity 99% 90% 80% 70% )

33836585

Synonyms (242)
Vendors (57)
Annotations (36)
Representations (1)
Notes (28)
Targets (76)
Clustered (34)
Reactome (16)
Rings (0)
Analogs (1)