Note Type	Comments	Provided By
UniProt Database Links	050L_FRG3G; 089R_FRG3G; 1A110_ARATH; 22K_ADES1; 254L_IIV6; 2SS_SOYBN; 33K_ADES1; 348R_IIV6; 3BP5L_BOVIN; 3BP5L_HUMAN; 3BP5L_MOUSE; 3BP5L_PONAB; 3BP5_HUMAN; 3BP5_MOUSE; 3BP5_RAT; AAAT_MOUSE; AAC4_DICDI; AACL_AGRT5; AADAT_BOVIN; AADAT_HUMAN; AADAT_MOUSE; AA	ChEBI
SOLUBILITY	1 M HCl: 100 mg/mL	Indofine
Melting_Point	115-118?	Alfa-Aesar
Melting_Point	115-118°	Alfa-Aesar
Melting_Point	189-192? dec.	Alfa-Aesar
Melting_Point	189-192° dec.	Alfa-Aesar
Mp [°C]	194	Acros Organics
MP	199°(dec.)	Oakwood Chemical
Melting_Point	203? dec.	Alfa-Aesar
Melting_Point	203° dec.	Alfa-Aesar
MP	205 °C (dec.)(lit.)	Indofine
Melting_Point	228? dec.	Alfa-Aesar
Melting_Point	228° dec.	Alfa-Aesar
UniProt Database Links	3HAPM_CUPPJ; A16A1_BOVIN; A16A1_HUMAN; A16A1_MOUSE; A16A1_RAT; AAAT_MOUSE; AACL_AGRT5; AADAT_BOVIN; AADAT_HUMAN; AADAT_MOUSE; AADAT_RAT; AAP1_ARATH; AAP2_ARATH; AAP5_ARATH; AAP8_ARATH; AASS_ARATH; AASS_BOVIN; AASS_HUMAN; AASS_MOUSE; AASS_RAT; AAT1_ARATH	ChEBI
ALOGPS_SOLUBILITY	8.06e+01 g/l	DrugBank-experimental
BP	94-97°/3mm	Oakwood Chemical
Purity	95%	Fluorochem
Purity	97%	APIChem
Purity	98%	Fluorochem
Melting_Point	ca 200? dec.	Alfa-Aesar
Melting_Point	ca 200° dec.	Alfa-Aesar
UniProt Database Links	CITE2_HUMAN; CITE2_MOUSE; GNAT3_BOVIN; GNAT3_HUMAN; GNAT3_MOUSE; GNAT3_RAT; MASZ_ECOLI; SER1_GALME; SER2_GALME; SERI1_BOMMO; SERO_GALME; TS1R1_HUMAN; TS1R1_MOUSE; TS1R1_RAT; TS1R3_CANFA; TS1R3_FELCA; TS1R3_GORGO; TS1R3_HUMAN; TS1R3_MOUSE; TS1R3_PANTR; TS1	ChEBI
UniProt Database Links	CSPG4_HUMAN; CSPG4_MOUSE; CSPG4_RAT; ENOA_BOVIN; ENOA_HUMAN; ENOA_MACFA; ENOA_MESAU; ENOA_MOUSE; ENOA_PONAB; ENOA_RAT; ENOB_MOUSE; HRG_BOVIN; HRG_HUMAN; HRG_MOUSE; HRG_RABIT; HRG_RAT; PDGFC_HUMAN; PDGFC_MOUSE; PDGFC_RAT; PLMN_BOVIN; PLMN_CANFA; PLMN_CAPHI	ChEBI
PUBCHEM_PATENT_ID	EP0019081A1; US4352792	IBM Patent Data
Patent Database Links	EP1127869; EP1291342; EP1422218; EP1541585; EP1568283; EP1609462; EP1616963; EP1627884; EP1632233; EP1714677; EP1745791; EP1752189; EP1762232; EP1849466; EP1867657; EP1958965; EP1967186; EP1983044; GB2096992; US2002159961; US2003049284; US2003125517; US20	ChEBI
Notes	Ph.Eur, Pyrogen free	Apollo Scientific Bioactives
Reactome Database Links	REACT_11083; REACT_11098; REACT_111140; REACT_111222; REACT_11134; REACT_11135; REACT_1136; REACT_116056; REACT_1171; REACT_12411; REACT_12503; REACT_12617; REACT_13574; REACT_13588; REACT_14; REACT_1427; REACT_14830; REACT_150192; REACT_15291; REACT_1532	ChEBI
S phrase	S24/25: Avoid contact with skin and eyes.	Acros Organics

Activity (Go SEA)

Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
AA3R-6-E	Adenosine Receptor A3 (cluster #6 Of 6), Eukaryotic	Eukaryotes	613	0.87	Binding ≤ 10μM
EAA3-2-E	Excitatory Amino Acid Transporter 3 (cluster #2 Of 2), Eukaryotic	Eukaryotes	51	1.02	Binding ≤ 10μM
GRIA1-3-E	Glutamate Receptor Ionotropic, AMPA 1 (cluster #3 Of 4), Eukaryotic	Eukaryotes	1360	0.82	Binding ≤ 10μM
GRIA2-3-E	Glutamate Receptor Ionotropic, AMPA 2 (cluster #3 Of 4), Eukaryotic	Eukaryotes	940	0.84	Binding ≤ 10μM
GRIA3-3-E	Glutamate Receptor Ionotropic, AMPA 3 (cluster #3 Of 4), Eukaryotic	Eukaryotes	500	0.88	Binding ≤ 10μM
GRIA4-3-E	Glutamate Receptor Ionotropic, AMPA 4 (cluster #3 Of 5), Eukaryotic	Eukaryotes	868	0.85	Binding ≤ 10μM
GRIK1-3-E	Glutamate Receptor Ionotropic Kainate 1 (cluster #3 Of 3), Eukaryotic	Eukaryotes	701	0.86	Binding ≤ 10μM
GRIK2-2-E	Glutamate Receptor Ionotropic Kainate 2 (cluster #2 Of 3), Eukaryotic	Eukaryotes	1106	0.83	Binding ≤ 10μM
GRIK3-2-E	Glutamate Receptor Ionotropic Kainate 3 (cluster #2 Of 3), Eukaryotic	Eukaryotes	789	0.85	Binding ≤ 10μM
GRIK4-2-E	Glutamate Receptor Ionotropic Kainate 4 (cluster #2 Of 2), Eukaryotic	Eukaryotes	700	0.86	Binding ≤ 10μM
GRIK5-2-E	Glutamate Receptor Ionotropic Kainate 5 (cluster #2 Of 2), Eukaryotic	Eukaryotes	700	0.86	Binding ≤ 10μM
GRM1-3-E	Metabotropic Glutamate Receptor 1 (cluster #3 Of 3), Eukaryotic	Eukaryotes	570	0.87	Binding ≤ 10μM
GRM2-1-E	Metabotropic Glutamate Receptor 2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	7400	0.72	Binding ≤ 10μM
GRM3-1-E	Metabotropic Glutamate Receptor 3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	3000	0.77	Binding ≤ 10μM
GRM4-3-E	Metabotropic Glutamate Receptor 4 (cluster #3 Of 3), Eukaryotic	Eukaryotes	2400	0.79	Binding ≤ 10μM
GRM5-4-E	Metabotropic Glutamate Receptor 5 (cluster #4 Of 5), Eukaryotic	Eukaryotes	4100	0.75	Binding ≤ 10μM
GRM6-1-E	Metabotropic Glutamate Receptor 6 (cluster #1 Of 1), Eukaryotic	Eukaryotes	7600	0.72	Binding ≤ 10μM
GRM8-1-E	Metabotropic Glutamate Receptor 8 (cluster #1 Of 2), Eukaryotic	Eukaryotes	3400	0.77	Binding ≤ 10μM
NMDZ1-4-E	Glutamate (NMDA) Receptor Subunit Zeta 1 (cluster #4 Of 6), Eukaryotic	Eukaryotes	450	0.89	Binding ≤ 10μM
GRIA1-3-E	Glutamate Receptor Ionotropic, AMPA 1 (cluster #3 Of 3), Eukaryotic	Eukaryotes	6160	0.73	Functional ≤ 10μM
GRIA2-3-E	Glutamate Receptor Ionotropic, AMPA 2 (cluster #3 Of 4), Eukaryotic	Eukaryotes	6200	0.73	Functional ≤ 10μM
GRIA3-2-E	Glutamate Receptor Ionotropic, AMPA 3 (cluster #2 Of 2), Eukaryotic	Eukaryotes	3660	0.76	Functional ≤ 10μM
GRM1-4-E	Metabotropic Glutamate Receptor 1 (cluster #4 Of 5), Eukaryotic	Eukaryotes	10000	0.70	Functional ≤ 10μM
GRM2-1-E	Metabotropic Glutamate Receptor 2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	8500	0.71	Functional ≤ 10μM
GRM3-1-E	Metabotropic Glutamate Receptor 3 (cluster #1 Of 2), Eukaryotic	Eukaryotes	9000	0.71	Functional ≤ 10μM
GRM4-1-E	Metabotropic Glutamate Receptor 4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	6100	0.73	Functional ≤ 10μM
GRM5-5-E	Metabotropic Glutamate Receptor 5 (cluster #5 Of 5), Eukaryotic	Eukaryotes	4900	0.74	Functional ≤ 10μM
GRM6-1-E	Metabotropic Glutamate Receptor 6 (cluster #1 Of 2), Eukaryotic	Eukaryotes	7600	0.72	Functional ≤ 10μM
GRM8-1-E	Metabotropic Glutamate Receptor 8 (cluster #1 Of 2), Eukaryotic	Eukaryotes	9500	0.70	Functional ≤ 10μM
NMDE1-1-E	Glutamate [NMDA] Receptor Subunit Epsilon 1 (cluster #1 Of 2), Eukaryotic	Eukaryotes	1800	0.80	Functional ≤ 10μM
NMDZ1-1-E	Glutamate (NMDA) Receptor Subunit Zeta 1 (cluster #1 Of 3), Eukaryotic	Eukaryotes	1800	0.80	Functional ≤ 10μM
Z104302-3-O	Glutamate NMDA Receptor (cluster #3 Of 7), Other	Other	870	0.85	Binding ≤ 10μM
Z50597-3-O	Rattus Norvegicus (cluster #3 Of 5), Other	Other	170	0.95	Binding ≤ 10μM
Z50597-7-O	Rattus Norvegicus (cluster #7 Of 12), Other	Other	1300	0.82	Functional ≤ 10μM

ChEMBL Target Annotations
Uniprot	Swissprot	Description	Affinity (nM)	LE (kcal/mol/atom)	Type
AA3R_HUMAN	P33765	Adenosine A3 Receptor, Human	613	0.87	Binding ≤ 1μM
EAA3_HUMAN	P43005	Excitatory Amino Acid Transporter 3, Human	51	1.02	Binding ≤ 1μM
NMDZ1_RAT	P35439	Glutamate (NMDA) Receptor Subunit Zeta 1, Rat	1000	0.84	Binding ≤ 1μM
Z104302	Z104302	Glutamate NMDA Receptor	1000	0.84	Binding ≤ 1μM
GRIK1_HUMAN	P39086	Glutamate Receptor Ionotropic Kainate 1, Human	701	0.86	Binding ≤ 1μM
GRIK1_RAT	P22756	Glutamate Receptor Ionotropic Kainate 1, Rat	138.038426	0.96	Binding ≤ 1μM
GRIK2_RAT	P42260	Glutamate Receptor Ionotropic Kainate 2, Rat	270	0.92	Binding ≤ 1μM
GRIK3_RAT	P42264	Glutamate Receptor Ionotropic Kainate 3, Rat	270	0.92	Binding ≤ 1μM
GRIK3_HUMAN	Q13003	Glutamate Receptor Ionotropic Kainate 3, Human	789	0.85	Binding ≤ 1μM
GRIK4_RAT	Q01812	Glutamate Receptor Ionotropic Kainate 4, Rat	270	0.92	Binding ≤ 1μM
GRIK5_RAT	Q63273	Glutamate Receptor Ionotropic Kainate 5, Rat	270	0.92	Binding ≤ 1μM
GRIK5_HUMAN	Q16478	Glutamate Receptor Ionotropic Kainate 5, Human	701	0.86	Binding ≤ 1μM
GRIA1_RAT	P19490	Glutamate Receptor Ionotropic, AMPA 1, Rat	169	0.95	Binding ≤ 1μM
GRIA2_RAT	P19491	Glutamate Receptor Ionotropic, AMPA 2, Rat	280	0.92	Binding ≤ 1μM
GRIA2_HUMAN	P42262	Glutamate Receptor Ionotropic, AMPA 2, Human	940	0.84	Binding ≤ 1μM
GRIA3_RAT	P19492	Glutamate Receptor Ionotropic, AMPA 3, Rat	249	0.92	Binding ≤ 1μM
GRIA4_HUMAN	P48058	Glutamate Receptor Ionotropic, AMPA 4, Human	868	0.85	Binding ≤ 1μM
GRIA4_RAT	P19493	Glutamate Receptor Ionotropic, AMPA 4, Rat	354	0.90	Binding ≤ 1μM
GRM1_HUMAN	Q13255	Metabotropic Glutamate Receptor 1, Human	250	0.92	Binding ≤ 1μM
GRM5_HUMAN	P41594	Metabotropic Glutamate Receptor 5, Human	390	0.90	Binding ≤ 1μM
GRM8_MOUSE	P47743	Metabotropic Glutamate Receptor 8, Mouse	22	1.07	Binding ≤ 1μM
GRM8_HUMAN	O00222	Metabotropic Glutamate Receptor 8, Human	5.7	1.15	Binding ≤ 1μM
Z50597	Z50597	Rattus Norvegicus	170	0.95	Binding ≤ 1μM
AA3R_HUMAN	P33765	Adenosine A3 Receptor, Human	613	0.87	Binding ≤ 10μM
EAA3_HUMAN	P43005	Excitatory Amino Acid Transporter 3, Human	51	1.02	Binding ≤ 10μM
NMDZ1_RAT	P35439	Glutamate (NMDA) Receptor Subunit Zeta 1, Rat	1000	0.84	Binding ≤ 10μM
Z104302	Z104302	Glutamate NMDA Receptor	1000	0.84	Binding ≤ 10μM
GRIK1_RAT	P22756	Glutamate Receptor Ionotropic Kainate 1, Rat	138.038426	0.96	Binding ≤ 10μM
GRIK1_HUMAN	P39086	Glutamate Receptor Ionotropic Kainate 1, Human	701	0.86	Binding ≤ 10μM
GRIK2_RAT	P42260	Glutamate Receptor Ionotropic Kainate 2, Rat	270	0.92	Binding ≤ 10μM
GRIK2_HUMAN	Q13002	Glutamate Receptor Ionotropic Kainate 2, Human	1106	0.83	Binding ≤ 10μM
GRIK3_HUMAN	Q13003	Glutamate Receptor Ionotropic Kainate 3, Human	789	0.85	Binding ≤ 10μM
GRIK3_RAT	P42264	Glutamate Receptor Ionotropic Kainate 3, Rat	270	0.92	Binding ≤ 10μM
GRIK4_RAT	Q01812	Glutamate Receptor Ionotropic Kainate 4, Rat	270	0.92	Binding ≤ 10μM
GRIK5_RAT	Q63273	Glutamate Receptor Ionotropic Kainate 5, Rat	270	0.92	Binding ≤ 10μM
GRIK5_HUMAN	Q16478	Glutamate Receptor Ionotropic Kainate 5, Human	701	0.86	Binding ≤ 10μM
GRIA1_RAT	P19490	Glutamate Receptor Ionotropic, AMPA 1, Rat	169	0.95	Binding ≤ 10μM
GRIA1_HUMAN	P42261	Glutamate Receptor Ionotropic, AMPA 1, Human	1360	0.82	Binding ≤ 10μM
GRIA1_MOUSE	P23818	Glutamate Receptor Ionotropic, AMPA 1, Mouse	1100	0.83	Binding ≤ 10μM
GRIA2_RAT	P19491	Glutamate Receptor Ionotropic, AMPA 2, Rat	1100	0.83	Binding ≤ 10μM
GRIA2_HUMAN	P42262	Glutamate Receptor Ionotropic, AMPA 2, Human	940	0.84	Binding ≤ 10μM
GRIA3_RAT	P19492	Glutamate Receptor Ionotropic, AMPA 3, Rat	1100	0.83	Binding ≤ 10μM
GRIA4_RAT	P19493	Glutamate Receptor Ionotropic, AMPA 4, Rat	1100	0.83	Binding ≤ 10μM
GRIA4_HUMAN	P48058	Glutamate Receptor Ionotropic, AMPA 4, Human	868	0.85	Binding ≤ 10μM
GRM1_HUMAN	Q13255	Metabotropic Glutamate Receptor 1, Human	250	0.92	Binding ≤ 10μM
GRM1_RAT	P23385	Metabotropic Glutamate Receptor 1, Rat	7300	0.72	Binding ≤ 10μM
GRM2_RAT	P31421	Metabotropic Glutamate Receptor 2, Rat	4000	0.76	Binding ≤ 10μM
GRM2_HUMAN	Q14416	Metabotropic Glutamate Receptor 2, Human	4700	0.75	Binding ≤ 10μM
GRM3_RAT	P31422	Metabotropic Glutamate Receptor 3, Rat	3000	0.77	Binding ≤ 10μM
GRM4_RAT	P31423	Metabotropic Glutamate Receptor 4, Rat	3200	0.77	Binding ≤ 10μM
GRM4_HUMAN	Q14833	Metabotropic Glutamate Receptor 4, Human	1400	0.82	Binding ≤ 10μM
GRM5_HUMAN	P41594	Metabotropic Glutamate Receptor 5, Human	1160	0.83	Binding ≤ 10μM
GRM5_RAT	P31424	Metabotropic Glutamate Receptor 5, Rat	10000	0.70	Binding ≤ 10μM
GRM6_RAT	P35349	Metabotropic Glutamate Receptor 6, Rat	7600	0.72	Binding ≤ 10μM
GRM8_RAT	P70579	Metabotropic Glutamate Receptor 8, Rat	3400	0.77	Binding ≤ 10μM
GRM8_MOUSE	P47743	Metabotropic Glutamate Receptor 8, Mouse	22	1.07	Binding ≤ 10μM
GRM8_HUMAN	O00222	Metabotropic Glutamate Receptor 8, Human	5.7	1.15	Binding ≤ 10μM
Z50597	Z50597	Rattus Norvegicus	170	0.95	Binding ≤ 10μM
NMDZ1_RAT	P35439	Glutamate (NMDA) Receptor Subunit Zeta 1, Rat	1800	0.80	Functional ≤ 10μM
GRIA1_RAT	P19490	Glutamate Receptor Ionotropic, AMPA 1, Rat	6400	0.73	Functional ≤ 10μM
GRIA1_HUMAN	P42261	Glutamate Receptor Ionotropic, AMPA 1, Human	2260	0.79	Functional ≤ 10μM
GRIA2_HUMAN	P42262	Glutamate Receptor Ionotropic, AMPA 2, Human	2190	0.79	Functional ≤ 10μM
GRIA3_RAT	P19492	Glutamate Receptor Ionotropic, AMPA 3, Rat	1300	0.82	Functional ≤ 10μM
GRIA3_HUMAN	P42263	Glutamate Receptor Ionotropic, AMPA 3, Human	3660	0.76	Functional ≤ 10μM
NMDE1_RAT	Q00959	Glutamate [NMDA] Receptor Subunit Epsilon 1, Rat	1800	0.80	Functional ≤ 10μM
GRM1_HUMAN	Q13255	Metabotropic Glutamate Receptor 1, Human	10000	0.70	Functional ≤ 10μM
GRM1_RAT	P23385	Metabotropic Glutamate Receptor 1, Rat	4900	0.74	Functional ≤ 10μM
GRM2_HUMAN	Q14416	Metabotropic Glutamate Receptor 2, Human	8500	0.71	Functional ≤ 10μM
GRM2_RAT	P31421	Metabotropic Glutamate Receptor 2, Rat	290	0.92	Functional ≤ 10μM
GRM3_HUMAN	Q14832	Metabotropic Glutamate Receptor 3, Human	2500	0.78	Functional ≤ 10μM
GRM3_RAT	P31422	Metabotropic Glutamate Receptor 3, Rat	290	0.92	Functional ≤ 10μM
GRM4_RAT	P31423	Metabotropic Glutamate Receptor 4, Rat	6100	0.73	Functional ≤ 10μM
GRM5_RAT	P31424	Metabotropic Glutamate Receptor 5, Rat	1200	0.83	Functional ≤ 10μM
GRM6_RAT	P35349	Metabotropic Glutamate Receptor 6, Rat	7600	0.72	Functional ≤ 10μM
GRM8_HUMAN	O00222	Metabotropic Glutamate Receptor 8, Human	9500	0.70	Functional ≤ 10μM
Z50597	Z50597	Rattus Norvegicus	1300	0.82	Functional ≤ 10μM

Direct Reactome Annotations (via ChEBI)

Description	Species
Activation of AMPA receptors	Taeniopygia guttata Mus musculus Canis familiaris Rattus norvegicus Danio rerio Caenorhabditis elegans Drosophila melanogaster Xenopus tropicalis Bos taurus Gallus gallus Sus scrofa Homo sapiens
Activation of Ca-permeable Kainate Receptor	Caenorhabditis elegans Canis familiaris Taeniopygia guttata Xenopus tropicalis Danio rerio Gallus gallus Bos taurus Drosophila melanogaster Sus scrofa Rattus norvegicus Homo sapiens Mus musculus
Activation of Na-permeable Kainate Receptors	Gallus gallus Bos taurus Taeniopygia guttata Mus musculus Sus scrofa Homo sapiens Rattus norvegicus Caenorhabditis elegans Danio rerio Drosophila melanogaster Canis familiaris Xenopus tropicalis
Aflatoxin activation and detoxification	Rattus norvegicus Schizosaccharomyces pombe Canis familiaris Mus musculus Taeniopygia guttata Arabidopsis thaliana Drosophila melanogaster Bos taurus Caenorhabditis elegans Saccharomyces cerevisiae Homo sapiens Sus scrofa Oryza sativa Gallus gallus Danio rerio Xenopus tropicalis
Amino acid metabolism	Gallus gallus
Amino acid synthesis and interconversion (transamination)	Bos taurus Plasmodium falciparum Drosophila melanogaster Mus musculus Gallus gallus Homo sapiens Canis familiaris Sus scrofa Saccharomyces cerevisiae Rattus norvegicus Taeniopygia guttata Oryza sativa Schizosaccharomyces pombe Caenorhabditis elegans Xenopus tropicalis Dictyostelium discoideum Arabidopsis thaliana Danio rerio
Amino acid transport across the plasma membrane	Rattus norvegicus Bos taurus Canis familiaris Sus scrofa Drosophila melanogaster Danio rerio Mus musculus Homo sapiens Xenopus tropicalis
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	Homo sapiens Oryza sativa Bos taurus Gallus gallus Caenorhabditis elegans Canis familiaris Xenopus tropicalis Danio rerio Mus musculus Rattus norvegicus Sus scrofa Dictyostelium discoideum Drosophila melanogaster
Antigen processing: Ubiquitination & Proteasome degradation	Mus musculus Drosophila melanogaster Taeniopygia guttata Canis familiaris Schizosaccharomyces pombe Homo sapiens Gallus gallus Danio rerio Saccharomyces cerevisiae Oryza sativa Sus scrofa Dictyostelium discoideum Xenopus tropicalis Rattus norvegicus Arabidopsis thaliana Plasmodium falciparum Caenorhabditis elegans Bos taurus
Astrocytic Glutamate-Glutamine Uptake And Metabolism	Rattus norvegicus Gallus gallus Schizosaccharomyces pombe Xenopus tropicalis Sus scrofa Saccharomyces cerevisiae Homo sapiens Mus musculus Danio rerio Taeniopygia guttata Canis familiaris Drosophila melanogaster Caenorhabditis elegans Oryza sativa Arabidopsis thaliana Bos taurus
Branched-chain amino acid catabolism	Gallus gallus Homo sapiens Saccharomyces cerevisiae Oryza sativa Taeniopygia guttata Xenopus tropicalis Mus musculus Rattus norvegicus Dictyostelium discoideum Schizosaccharomyces pombe Drosophila melanogaster Canis familiaris Arabidopsis thaliana Danio rerio Sus scrofa Bos taurus Caenorhabditis elegans
Class C/3 (Metabotropic glutamate/pheromone receptors)	Canis familiaris Taeniopygia guttata Caenorhabditis elegans Sus scrofa Danio rerio Bos taurus Rattus norvegicus Gallus gallus Xenopus tropicalis Homo sapiens Drosophila melanogaster Mus musculus
CREB phosphorylation through the activation of CaMKII	Mus musculus Xenopus tropicalis Gallus gallus Danio rerio Canis familiaris Caenorhabditis elegans Bos taurus Drosophila melanogaster Taeniopygia guttata Homo sapiens Sus scrofa Rattus norvegicus
Cross-presentation of soluble exogenous antigens (endosomes)	Schizosaccharomyces pombe Homo sapiens Drosophila melanogaster Dictyostelium discoideum Danio rerio Arabidopsis thaliana Plasmodium falciparum Mus musculus Oryza sativa Sus scrofa Canis familiaris Taeniopygia guttata Rattus norvegicus Caenorhabditis elegans Gallus gallus Bos taurus Xenopus tropicalis Saccharomyces cerevisiae
Cytosolic tRNA aminoacylation	Arabidopsis thaliana Gallus gallus Drosophila melanogaster Dictyostelium discoideum Xenopus tropicalis Bos taurus Danio rerio Mus musculus Oryza sativa Canis familiaris Homo sapiens Sus scrofa Taeniopygia guttata Rattus norvegicus Plasmodium falciparum
De novo synthesis of GMP	Gallus gallus
De novo synthesis of IMP	Gallus gallus
De novo synthesis of UMP	Gallus gallus
Degradation of GABA	Rattus norvegicus Sus scrofa Canis familiaris Oryza sativa Homo sapiens Xenopus tropicalis Mus musculus Drosophila melanogaster Caenorhabditis elegans Danio rerio Schizosaccharomyces pombe Gallus gallus Arabidopsis thaliana Saccharomyces cerevisiae Taeniopygia guttata Bos taurus Dictyostelium discoideum
Endosomal/Vacuolar pathway	Sus scrofa Canis familiaris Gallus gallus Rattus norvegicus Caenorhabditis elegans Xenopus tropicalis Bos taurus Taeniopygia guttata Dictyostelium discoideum Danio rerio Homo sapiens Drosophila melanogaster Mus musculus
EPHB-mediated forward signaling	Mus musculus Danio rerio Caenorhabditis elegans Gallus gallus Rattus norvegicus Sus scrofa Canis familiaris Taeniopygia guttata Homo sapiens Drosophila melanogaster Bos taurus Xenopus tropicalis
ER-Phagosome pathway	Drosophila melanogaster Caenorhabditis elegans Gallus gallus Taeniopygia guttata Plasmodium falciparum Dictyostelium discoideum Oryza sativa Danio rerio Arabidopsis thaliana Canis familiaris Sus scrofa Xenopus tropicalis Homo sapiens Saccharomyces cerevisiae Mus musculus Schizosaccharomyces pombe Rattus norvegicus Bos taurus
G alpha (i) signalling events	Sus scrofa Drosophila melanogaster Homo sapiens Bos taurus Taeniopygia guttata Canis familiaris Mus musculus Gallus gallus Rattus norvegicus Xenopus tropicalis Danio rerio Caenorhabditis elegans
G alpha (q) signalling events	Xenopus tropicalis Taeniopygia guttata Canis familiaris Rattus norvegicus Mus musculus Gallus gallus Sus scrofa Bos taurus Homo sapiens Danio rerio
GABA synthesis	Canis familiaris Rattus norvegicus Gallus gallus Homo sapiens Xenopus tropicalis Mus musculus Caenorhabditis elegans Sus scrofa Bos taurus Drosophila melanogaster Danio rerio Taeniopygia guttata
Gluconeogenesis	Danio rerio Sus scrofa Bos taurus Caenorhabditis elegans Taeniopygia guttata Oryza sativa Xenopus tropicalis Drosophila melanogaster Mus musculus Homo sapiens Canis familiaris Saccharomyces cerevisiae Dictyostelium discoideum Arabidopsis thaliana Gallus gallus Rattus norvegicus Plasmodium falciparum Gallus gallus Schizosaccharomyces pombe
Glutamate Neurotransmitter Release Cycle	Drosophila melanogaster Dictyostelium discoideum Caenorhabditis elegans Rattus norvegicus Homo sapiens Mus musculus Canis familiaris Danio rerio Gallus gallus Xenopus tropicalis Bos taurus Taeniopygia guttata Sus scrofa
Glutathione synthesis and recycling	Oryza sativa Danio rerio Rattus norvegicus Homo sapiens Saccharomyces cerevisiae Canis familiaris Arabidopsis thaliana Taeniopygia guttata Caenorhabditis elegans Xenopus tropicalis Bos taurus Schizosaccharomyces pombe Gallus gallus Dictyostelium discoideum Sus scrofa Mus musculus Drosophila melanogaster
Histidine catabolism	Danio rerio Xenopus tropicalis Dictyostelium discoideum Bos taurus Canis familiaris Mus musculus Rattus norvegicus Homo sapiens Sus scrofa Taeniopygia guttata Gallus gallus
Lysine catabolism	Gallus gallus Homo sapiens Mus musculus Dictyostelium discoideum Bos taurus Taeniopygia guttata Sus scrofa Canis familiaris Caenorhabditis elegans Arabidopsis thaliana Xenopus tropicalis Saccharomyces cerevisiae Drosophila melanogaster Oryza sativa Rattus norvegicus Schizosaccharomyces pombe Danio rerio
Metabolism of folate and pterines	Gallus gallus Bos taurus Danio rerio Mus musculus Plasmodium falciparum Homo sapiens Canis familiaris Dictyostelium discoideum Oryza sativa Rattus norvegicus Arabidopsis thaliana Sus scrofa Saccharomyces cerevisiae Drosophila melanogaster Schizosaccharomyces pombe Caenorhabditis elegans Taeniopygia guttata Xenopus tropicalis
Mitochondrial tRNA aminoacylation	Bos taurus Plasmodium falciparum Gallus gallus Dictyostelium discoideum Saccharomyces cerevisiae Danio rerio Xenopus tropicalis Mus musculus Homo sapiens Sus scrofa Oryza sativa Rattus norvegicus Drosophila melanogaster Canis familiaris Taeniopygia guttata Schizosaccharomyces pombe Caenorhabditis elegans Arabidopsis thaliana
Nicotinate metabolism	Sus scrofa Mus musculus Danio rerio Gallus gallus Dictyostelium discoideum Canis familiaris Saccharomyces cerevisiae Oryza sativa Caenorhabditis elegans Taeniopygia guttata Arabidopsis thaliana Rattus norvegicus Schizosaccharomyces pombe Homo sapiens Drosophila melanogaster Plasmodium falciparum Bos taurus Xenopus tropicalis
Organic anion transporters	Taeniopygia guttata Sus scrofa Homo sapiens Gallus gallus Caenorhabditis elegans Rattus norvegicus Bos taurus Drosophila melanogaster Danio rerio Canis familiaris Xenopus tropicalis Mus musculus
Phenylalanine and tyrosine catabolism	Gallus gallus Mus musculus Homo sapiens Danio rerio Arabidopsis thaliana Sus scrofa Oryza sativa Dictyostelium discoideum Canis familiaris Caenorhabditis elegans Drosophila melanogaster Taeniopygia guttata Xenopus tropicalis Bos taurus Rattus norvegicus
Presynaptic function of Kainate receptors	Bos taurus Xenopus tropicalis Homo sapiens Caenorhabditis elegans Drosophila melanogaster Rattus norvegicus Canis familiaris Taeniopygia guttata Sus scrofa Gallus gallus Danio rerio Mus musculus
Proline catabolism	Caenorhabditis elegans Oryza sativa Homo sapiens Sus scrofa Rattus norvegicus Schizosaccharomyces pombe Gallus gallus Mus musculus Dictyostelium discoideum Taeniopygia guttata Bos taurus Saccharomyces cerevisiae Canis familiaris Drosophila melanogaster Danio rerio Xenopus tropicalis
Proton/oligonucleotide cotransporters	Drosophila melanogaster Bos taurus Oryza sativa Caenorhabditis elegans Xenopus tropicalis Dictyostelium discoideum Taeniopygia guttata Homo sapiens Arabidopsis thaliana Mus musculus Sus scrofa Canis familiaris Danio rerio Rattus norvegicus Gallus gallus
Purine ribonucleoside monophosphate biosynthesis	Oryza sativa Schizosaccharomyces pombe Sus scrofa Rattus norvegicus Danio rerio Gallus gallus Drosophila melanogaster Mus musculus Caenorhabditis elegans Bos taurus Taeniopygia guttata Arabidopsis thaliana Saccharomyces cerevisiae Plasmodium falciparum Xenopus tropicalis Homo sapiens Dictyostelium discoideum Canis familiaris
Pyrimidine biosynthesis	Sus scrofa Danio rerio Drosophila melanogaster Xenopus tropicalis Homo sapiens Canis familiaris Schizosaccharomyces pombe Plasmodium falciparum Arabidopsis thaliana Rattus norvegicus Bos taurus Taeniopygia guttata Dictyostelium discoideum Saccharomyces cerevisiae Gallus gallus Caenorhabditis elegans Mus musculus
Ras activation uopn Ca2+ infux through NMDA receptor	Sus scrofa Bos taurus Danio rerio Gallus gallus Homo sapiens Canis familiaris Xenopus tropicalis Rattus norvegicus Mus musculus Taeniopygia guttata
Serine biosynthesis	Sus scrofa Caenorhabditis elegans Arabidopsis thaliana Canis familiaris Oryza sativa Homo sapiens Saccharomyces cerevisiae Dictyostelium discoideum Rattus norvegicus Danio rerio Schizosaccharomyces pombe Taeniopygia guttata Mus musculus Xenopus tropicalis Bos taurus Gallus gallus Drosophila melanogaster
Sulfur amino acid metabolism	Taeniopygia guttata Xenopus tropicalis Rattus norvegicus Drosophila melanogaster Gallus gallus Bos taurus Mus musculus Canis familiaris Sus scrofa Danio rerio Schizosaccharomyces pombe Homo sapiens Caenorhabditis elegans
Synthesis and interconversion of nucleotide di- and triphosphates	Arabidopsis thaliana Xenopus tropicalis Rattus norvegicus Saccharomyces cerevisiae Canis familiaris Caenorhabditis elegans Sus scrofa Schizosaccharomyces pombe Homo sapiens Dictyostelium discoideum Taeniopygia guttata Mus musculus Bos taurus Plasmodium falciparum Danio rerio Oryza sativa Gallus gallus Drosophila melanogaster
Synthesis of Leukotrienes (LT) and Eoxins (EX)	Gallus gallus Homo sapiens Schizosaccharomyces pombe Arabidopsis thaliana Saccharomyces cerevisiae Sus scrofa Xenopus tropicalis Bos taurus Mus musculus Taeniopygia guttata Canis familiaris Caenorhabditis elegans Danio rerio Rattus norvegicus Oryza sativa Drosophila melanogaster
Synthesis of UDP-N-acetyl-glucosamine	Taeniopygia guttata Xenopus tropicalis Drosophila melanogaster Saccharomyces cerevisiae Gallus gallus Canis familiaris Danio rerio Sus scrofa Bos taurus Schizosaccharomyces pombe Arabidopsis thaliana Rattus norvegicus Plasmodium falciparum Dictyostelium discoideum Mus musculus Caenorhabditis elegans Oryza sativa Homo sapiens
Transport of inorganic cations/anions and amino acids/oligopeptides	Mus musculus Canis familiaris Homo sapiens Sus scrofa Gallus gallus Drosophila melanogaster Rattus norvegicus Xenopus tropicalis Bos taurus Danio rerio Taeniopygia guttata Caenorhabditis elegans
Tryptophan catabolism	Drosophila melanogaster Mus musculus Canis familiaris Bos taurus Rattus norvegicus Taeniopygia guttata Sus scrofa Schizosaccharomyces pombe Xenopus tropicalis Dictyostelium discoideum Danio rerio Saccharomyces cerevisiae Gallus gallus Homo sapiens
Unblocking of NMDA receptor, glutamate binding and activation	Caenorhabditis elegans Taeniopygia guttata Gallus gallus Drosophila melanogaster Sus scrofa Xenopus tropicalis Danio rerio Bos taurus Canis familiaris Homo sapiens Mus musculus Rattus norvegicus
Urea cycle	Sus scrofa Canis familiaris Xenopus tropicalis Saccharomyces cerevisiae Rattus norvegicus Danio rerio Homo sapiens Dictyostelium discoideum Mus musculus Schizosaccharomyces pombe Bos taurus

Reactome Annotations from Targets (via Uniprot)

Description	Species
Activation of AMPA receptors	Homo sapiens (GRIA1_HUMAN) Mus musculus (GRIA1_MOUSE)
Activation of Ca-permeable Kainate Receptor	Rattus norvegicus (GRIK1_RAT) Homo sapiens (GRIK1_HUMAN)
Activation of Na-permeable Kainate Receptors	Homo sapiens (GRIK1_HUMAN) Rattus norvegicus (GRIK1_RAT)
Adenosine P1 receptors	Homo sapiens (AA3R_HUMAN)
Class C/3 (Metabotropic glutamate/pheromone receptors)	Homo sapiens (GRM8_HUMAN) Rattus norvegicus (GRM2_RAT) Mus musculus (GRM8_MOUSE)
CREB phosphorylation through the activation of CaMKII	Rattus norvegicus (NMDZ1_RAT)
EPHB-mediated forward signaling	Rattus norvegicus (NMDZ1_RAT)
G alpha (i) signalling events	Homo sapiens (GRM8_HUMAN) Rattus norvegicus (GRM2_RAT) Mus musculus (GRM8_MOUSE)
G alpha (q) signalling events	Rattus norvegicus (GRM5_RAT) Homo sapiens (GRM5_HUMAN)
Glutamate Neurotransmitter Release Cycle	Homo sapiens (EAA3_HUMAN)
Presynaptic function of Kainate receptors	Homo sapiens (GRIK3_HUMAN)
Ras activation uopn Ca2+ infux through NMDA receptor	Rattus norvegicus (NMDZ1_RAT)
Trafficking of AMPA receptors	Homo sapiens (GRIA1_HUMAN)
Trafficking of GluR2-containing AMPA receptors	Mus musculus (GRIA1_MOUSE) Homo sapiens (GRIA1_HUMAN)
Transport of inorganic cations/anions and amino acids/oligopeptides	Homo sapiens (EAA3_HUMAN)
Unblocking of NMDA receptor, glutamate binding and activation	Rattus norvegicus (NMDZ1_RAT) Homo sapiens (GRIA1_HUMAN) Mus musculus (GRIA1_MOUSE)

Analogs ( Draw Identity 99% 90% 80% 70% )

33836585

Synonyms (242)
Vendors (57)
Annotations (36)
Representations (1)
Notes (28)
Targets (76)
Clustered (34)
Reactome (16)
Rings (0)
Analogs (1)