UCSF

Lysophosphatidic Acid Receptor Edg-4, Human (59 Compounds)

Swissprot:
LPAR2_HUMAN
Stitch:
LPAR2_HUMAN
UniProt:
Q9HBW0
ChEMBL:
CHEMBL3724
Reactome:
REACT_19231
REACT_18283
REACT_18365
PDB:
LPAR2

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 59 3 0 0
Binding ≤ 1μM 36 0 0 0
Functional ≤ 10μM 47 8 2 0

Reactome Network (3)

Reactome ID Description Species
REACT_19231 G alpha (i) signalling events Homo sapiens
REACT_18283 G alpha (q) signalling events Homo sapiens
REACT_18365 Lysosphingolipid and LPA receptors Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
LPAR1_HUMAN Q92633 CHEMBL3819 Lysophosphatidic Acid Receptor Edg-2, Human 27
LPAR3_HUMAN Q9UBY5 CHEMBL3250 Lysophosphatidic Acid Receptor Edg-7, Human 27
LPAR5_HUMAN Q9H1C0 CHEMBL5700 Lysophosphatidic Acid Receptor 5, Human 1
S1PR1_HUMAN P21453 CHEMBL4333 Sphingosine 1-phosphate Receptor Edg-1, Human 30
S1PR2_HUMAN O95136 CHEMBL2955 Sphingosine 1-phosphate Receptor Edg-5, Human 28
S1PR3_HUMAN Q99500 CHEMBL3892 Sphingosine 1-phosphate Receptor Edg-3, Human 29
S1PR4_HUMAN O95977 CHEMBL3230 Sphingosine 1-phosphate Receptor Edg-6, Human 2
S1PR5_HUMAN Q9H228 CHEMBL2274 Sphingosine 1-phosphate Receptor Edg-8, Human 2

G alpha (q) signalling events

Uniprot Swissprot Chembl Description Number Shared
LPAR1_HUMAN Q92633 CHEMBL3819 Lysophosphatidic Acid Receptor Edg-2, Human 27
LPAR3_HUMAN Q9UBY5 CHEMBL3250 Lysophosphatidic Acid Receptor Edg-7, Human 27
LPAR5_HUMAN Q9H1C0 CHEMBL5700 Lysophosphatidic Acid Receptor 5, Human 1

Lysosphingolipid and LPA receptors

Uniprot Swissprot Chembl Description Number Shared
LPAR1_HUMAN Q92633 CHEMBL3819 Lysophosphatidic Acid Receptor Edg-2, Human 27
LPAR3_HUMAN Q9UBY5 CHEMBL3250 Lysophosphatidic Acid Receptor Edg-7, Human 27
LPAR5_HUMAN Q9H1C0 CHEMBL5700 Lysophosphatidic Acid Receptor 5, Human 1
S1PR1_HUMAN P21453 CHEMBL4333 Sphingosine 1-phosphate Receptor Edg-1, Human 30
S1PR2_HUMAN O95136 CHEMBL2955 Sphingosine 1-phosphate Receptor Edg-5, Human 28
S1PR3_HUMAN Q99500 CHEMBL3892 Sphingosine 1-phosphate Receptor Edg-3, Human 29
S1PR4_HUMAN O95977 CHEMBL3230 Sphingosine 1-phosphate Receptor Edg-6, Human 2
S1PR5_HUMAN Q9H228 CHEMBL2274 Sphingosine 1-phosphate Receptor Edg-8, Human 2
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
LPAR1_HUMAN Q92633 CHEMBL3819 Lysophosphatidic Acid Receptor Edg-2, Human 59 5 0 0
LPAR3_HUMAN Q9UBY5 CHEMBL3250 Lysophosphatidic Acid Receptor Edg-7, Human 80 5 0 1
LPAR5_HUMAN Q9H1C0 CHEMBL5700 Lysophosphatidic Acid Receptor 5, Human 1 1 0 0

Clustered By Gene (0)

Clustered By Organism (1)

Code Description Substances Purchasable Natural In Man
LPAR2-1-E Lysophosphatidic Acid Receptor Edg-4 (cluster #1 Of 2), Eukaryotic 33 3 0 0
LPAR2-2-E Lysophosphatidic Acid Receptor Edg-4 (cluster #2 Of 2), Eukaryotic 30 0 0 0
Uniprot Swissprot Chembl Description Number Shared
S1PR1_HUMAN P21453 CHEMBL4333 Sphingosine 1-phosphate Receptor Edg-1, Human 30
S1PR3_HUMAN Q99500 CHEMBL3892 Sphingosine 1-phosphate Receptor Edg-3, Human 29
S1PR2_HUMAN O95136 CHEMBL2955 Sphingosine 1-phosphate Receptor Edg-5, Human 28
LPAR1_HUMAN Q92633 CHEMBL3819 Lysophosphatidic Acid Receptor Edg-2, Human 27
LPAR3_HUMAN Q9UBY5 CHEMBL3250 Lysophosphatidic Acid Receptor Edg-7, Human 27
ENPP2_HUMAN Q13822 CHEMBL3691 Autotaxin, Human 16
LPAR1_RAT P61794 CHEMBL4595 Lysophosphatidic Acid Receptor Edg-2, Rat 16
Z80390 Z80390 CHEMBL390 PC-3 (Prostate Carcinoma Cells) 14
LPAR3_RAT Q8K5E0 CHEMBL4424 Lysophosphatidic Acid Receptor Edg-7, Rat 9
Z50587 Z50587 CHEMBL372 Homo Sapiens 4
S1PR4_HUMAN O95977 CHEMBL3230 Sphingosine 1-phosphate Receptor Edg-6, Human 2
S1PR5_HUMAN Q9H228 CHEMBL2274 Sphingosine 1-phosphate Receptor Edg-8, Human 2
LPAR5_HUMAN Q9H1C0 CHEMBL5700 Lysophosphatidic Acid Receptor 5, Human 1