UCSF

Sphingosine 1-phosphate Receptor Edg-6, Human (206 Compounds)

Swissprot:
S1PR4_HUMAN
Stitch:
S1PR4_HUMAN
UniProt:
O95977
ChEMBL:
CHEMBL3230
Reactome:
REACT_19231
REACT_18365
PDB:
2DCO (DOCK)
S1PR4

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 206 5 4 0
Binding ≤ 1μM 167 5 4 0
Functional ≤ 10μM 64 6 0 0

Reactome Network (2)

Reactome ID Description Species
REACT_19231 G alpha (i) signalling events Homo sapiens
REACT_18365 Lysosphingolipid and LPA receptors Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
LPAR2_HUMAN Q9HBW0 CHEMBL3724 Lysophosphatidic Acid Receptor Edg-4, Human 2
S1PR1_HUMAN P21453 CHEMBL4333 Sphingosine 1-phosphate Receptor Edg-1, Human 216
S1PR2_HUMAN O95136 CHEMBL2955 Sphingosine 1-phosphate Receptor Edg-5, Human 80
S1PR3_HUMAN Q99500 CHEMBL3892 Sphingosine 1-phosphate Receptor Edg-3, Human 177
S1PR5_HUMAN Q9H228 CHEMBL2274 Sphingosine 1-phosphate Receptor Edg-8, Human 173

Lysosphingolipid and LPA receptors

Uniprot Swissprot Chembl Description Number Shared
LPAR2_HUMAN Q9HBW0 CHEMBL3724 Lysophosphatidic Acid Receptor Edg-4, Human 2
S1PR1_HUMAN P21453 CHEMBL4333 Sphingosine 1-phosphate Receptor Edg-1, Human 216
S1PR2_HUMAN O95136 CHEMBL2955 Sphingosine 1-phosphate Receptor Edg-5, Human 80
S1PR3_HUMAN Q99500 CHEMBL3892 Sphingosine 1-phosphate Receptor Edg-3, Human 177
S1PR5_HUMAN Q9H228 CHEMBL2274 Sphingosine 1-phosphate Receptor Edg-8, Human 173
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
S1PR1_HUMAN P21453 CHEMBL4333 Sphingosine 1-phosphate Receptor Edg-1, Human 487 13 7 2
S1PR2_HUMAN O95136 CHEMBL2955 Sphingosine 1-phosphate Receptor Edg-5, Human 116 4 2 0
S1PR3_HUMAN Q99500 CHEMBL3892 Sphingosine 1-phosphate Receptor Edg-3, Human 317 5 4 1
S1PR5_HUMAN Q9H228 CHEMBL2274 Sphingosine 1-phosphate Receptor Edg-8, Human 207 8 6 1

Clustered By Gene (0)

Clustered By Organism (1)

Code Description Substances Purchasable Natural In Man
S1PR4-1-E Sphingosine 1-phosphate Receptor Edg-6 (cluster #1 Of 2), Eukaryotic 156 0 0 0
S1PR4-2-E Sphingosine 1-phosphate Receptor Edg-6 (cluster #2 Of 2), Eukaryotic 57 9 7 0
Uniprot Swissprot Chembl Description Number Shared
S1PR1_HUMAN P21453 CHEMBL4333 Sphingosine 1-phosphate Receptor Edg-1, Human 213
S1PR3_HUMAN Q99500 CHEMBL3892 Sphingosine 1-phosphate Receptor Edg-3, Human 175
S1PR5_HUMAN Q9H228 CHEMBL2274 Sphingosine 1-phosphate Receptor Edg-8, Human 171
S1PR2_HUMAN O95136 CHEMBL2955 Sphingosine 1-phosphate Receptor Edg-5, Human 74
LPAR2_HUMAN Q9HBW0 CHEMBL3724 Lysophosphatidic Acid Receptor Edg-4, Human 2
SPHK1_HUMAN Q9NYA1 CHEMBL4394 Sphingosine Kinase 1, Human 1

Most Common Rings