| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| October 4th, 2005 | 25 | Yes |
Popular Name: Disopyramide Phosphate Disopyramide Phosphate
Find On: PubMed — Wikipedia — Google
CAS Numbers: 1309283-08-6 , 22059-60-5 , 22059-60-5, 3737-09-5 , 3737-09-5 , [22059-60-5] , [3737-09-5]
2-Pyridineacetamide, .alpha.-[2-[bis(1-methylethyl)amino]ethyl]-.alpha.-phenyl-
2-Pyridineacetamide, alpha-(2-(bis(1-methylethyl)amino)ethyl)-alpha-phenyl-
2-Pyridineacetamide, alpha-(2-(diisopropylamino)ethyl)-alpha-phenyl-
22059-60-5; C07740; Disopyramide phosphate
22059-60-5; D00637; Disopyramide phosphate (JAN/USP); Norpace (TN)
3737-09-5; Disopyramide; Prestwick_681
4-(diisopropylamino)-2-phenyl-2-pyridin-2-ylbutanamide
4-[di(propan-2-yl)amino]-2-phenyl-2-pyridin-2-ylbutanamide
54687-36-4 (mono-hydrochloride)
alpha-(2-(Diisopropylamino)ethyl)-alpha-phenyl-2-pyridineacetamide
alpha-Diisopropylaminoethyl-alpha-phenylpyridine-2-acetamide
alpha-[2-[Bis(1-methylethyl)amino]ethyl]- alpha-phenyl-2-pyridine acetamide
CPD000058438; Norpace; SAM002264607
Disopiramida [INN-Spanish];Disopyramide Free Base;Disopyramide Phosphate;Disopyramidum [INN-Latin]
disopiramida; disopyramide; disopyramidum
Disopyramide [USAN:BAN:INN:JAN]
gamma-Diisopropylamino-alpha-phenyl-alpha-(2-pyridyl)butyramide
USAN); Disopyramide Phosphate (BAN
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 2.78 | 8.24 | -40.49 | 3 | 4 | 1 | 60 | 340.491 | 8 | ↓ |
| Hi High (pH 8-9.5) | -1.21 | -6.06 | -16.4 | 6 | 11 | 0 | 175 | 438.47 | 9 | ↓ |
| Note Type | Comments | Provided By |
|---|---|---|
| ALOGPS_SOLUBILITY | 4.93e-02 g/l | DrugBank-approved |
| Indications | antiarrhythmic | KeyOrganics Bioactives |
| Patent Database Links | EP1438962; EP1586349; EP1655286; EP1764111; EP1785145; EP1990639; US2002115655; US2004254182; US2005070552; US2007207222; US2007219221; US2007232536; US2007238674; US2007258894; WO2005018635; WO2007103687; WO2007112288; WO2007112581; WO2007117621 | ChEBI |
| Therapy | K+ channel modulator; anti-arrhythmic; cardiac depressant | SMDC Iconix |
| PUBCHEM_SUBSTANCE_COMMENT | NCC_SAMPLE_SUPPLIER : LightBiologicals; NCC_SUPPLIER_STRUCTURE_ID : D-8639; 1 Phosphoric acid | NIH Clinical Collection via PubChem |
| Target | Others | Selleck Chemicals |
| PUBCHEM_SUBSTANCE_COMMENT | SAMPLE_SUPPLIER: LightBiologicals; SUPPLIER_STRUCTURE_ID: D-8639; SALT: 1 Phosphoric acid | NIH Clinical Collection via PubChem |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| KCNH2-5-E | HERG (cluster #5 Of 5), Eukaryotic | Eukaryotes | 4040 | 0.30 | Binding ≤ 10μM |
| Z50425-3-O | Plasmodium Falciparum (cluster #3 Of 22), Other | Other | 10000 | 0.28 | Functional ≤ 10μM |
| Z50512-1-O | Cavia Porcellus (cluster #1 Of 7), Other | Other | 4500 | 0.30 | Functional ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| KCNH2_HUMAN | Q12809 | HERG, Human | 4040 | 0.30 | Binding ≤ 10μM |
| Z50512 | Z50512 | Cavia Porcellus | 1500 | 0.33 | Functional ≤ 10μM |
| Z50425 | Z50425 | Plasmodium Falciparum | 10000 | 0.28 | Functional ≤ 10μM |
| Description | Species |
|---|---|
| Voltage gated Potassium channels |
