| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| November 13th, 2008 | 12 | No |
Popular Name: Ap-5 lithium salt Ap-5 lithium salt
Find On: PubMed — Wikipedia — Google
CAS Numbers: 125229-62-1 , 76326-31-3 , [79055-68-8]
(R)-2-Amino-5-phosphono-pentanoic acid
2-amino-5-phosphonopentanoic acid
2-Amino-5-phosphonovaleric acid; 2-Amino-5-phosphovaleric acid
2-Amino-5-phosphopentanoic acid; 76326-31-3; C13734
5-Phosphono-D-norvaline; D-2-Amino-5-phosphopentanoic acid; D-Norvaline, 5-phosphono-; LS-183830
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | -3.75 | -0.93 | -61.42 | 4 | 6 | -1 | 128 | 196.119 | 5 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| NMD3A-2-E | Glutamate [NMDA] Receptor Subunit 3A (cluster #2 Of 6), Eukaryotic | Eukaryotes | 3700 | 0.63 | Binding ≤ 10μM |
| NMD3B-2-E | Glutamate [NMDA] Receptor Subunit 3B (cluster #2 Of 6), Eukaryotic | Eukaryotes | 3700 | 0.63 | Binding ≤ 10μM |
| NMDE1-4-E | Glutamate [NMDA] Receptor Subunit Epsilon 1 (cluster #4 Of 5), Eukaryotic | Eukaryotes | 280 | 0.76 | Binding ≤ 10μM |
| NMDE1-4-E | Glutamate [NMDA] Receptor Subunit Epsilon 1 (cluster #4 Of 5), Eukaryotic | Eukaryotes | 3700 | 0.63 | Binding ≤ 10μM |
| NMDE2-4-E | Glutamate [NMDA] Receptor Subunit Epsilon 2 (cluster #4 Of 5), Eukaryotic | Eukaryotes | 460 | 0.74 | Binding ≤ 10μM |
| NMDE2-4-E | Glutamate [NMDA] Receptor Subunit Epsilon 2 (cluster #4 Of 5), Eukaryotic | Eukaryotes | 3700 | 0.63 | Binding ≤ 10μM |
| NMDE3-3-E | Glutamate [NMDA] Receptor Subunit Epsilon 3 (cluster #3 Of 4), Eukaryotic | Eukaryotes | 280 | 0.76 | Binding ≤ 10μM |
| NMDE3-3-E | Glutamate [NMDA] Receptor Subunit Epsilon 3 (cluster #3 Of 4), Eukaryotic | Eukaryotes | 3700 | 0.63 | Binding ≤ 10μM |
| NMDE4-2-E | Glutamate [NMDA] Receptor Subunit Epsilon 4 (cluster #2 Of 6), Eukaryotic | Eukaryotes | 176 | 0.79 | Binding ≤ 10μM |
| NMDE4-2-E | Glutamate [NMDA] Receptor Subunit Epsilon 4 (cluster #2 Of 6), Eukaryotic | Eukaryotes | 3710 | 0.63 | Binding ≤ 10μM |
| NMDZ1-4-E | Glutamate (NMDA) Receptor Subunit Zeta 1 (cluster #4 Of 6), Eukaryotic | Eukaryotes | 460 | 0.74 | Binding ≤ 10μM |
| NMDZ1-4-E | Glutamate (NMDA) Receptor Subunit Zeta 1 (cluster #4 Of 6), Eukaryotic | Eukaryotes | 3700 | 0.63 | Binding ≤ 10μM |
| Z104302-3-O | Glutamate NMDA Receptor (cluster #3 Of 7), Other | Other | 420 | 0.74 | Binding ≤ 10μM |
| Z104302-3-O | Glutamate NMDA Receptor (cluster #3 Of 7), Other | Other | 880 | 0.71 | Binding ≤ 10μM |
| Z50597-2-O | Rattus Norvegicus (cluster #2 Of 12), Other | Other | 6100 | 0.61 | Functional ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| NMDZ1_RAT | P35439 | Glutamate (NMDA) Receptor Subunit Zeta 1, Rat | 170 | 0.79 | Binding ≤ 1μM |
| NMDZ1_HUMAN | Q05586 | Glutamate (NMDA) Receptor Subunit Zeta 1, Human | 177 | 0.79 | Binding ≤ 1μM |
| Z104302 | Z104302 | Glutamate NMDA Receptor | 1000 | 0.70 | Binding ≤ 1μM |
| NMD3A_HUMAN | Q8TCU5 | Glutamate [NMDA] Receptor Subunit 3A, Human | 177 | 0.79 | Binding ≤ 1μM |
| NMD3B_HUMAN | O60391 | Glutamate [NMDA] Receptor Subunit 3B, Human | 177 | 0.79 | Binding ≤ 1μM |
| NMDE1_RAT | Q00959 | Glutamate [NMDA] Receptor Subunit Epsilon 1, Rat | 176 | 0.79 | Binding ≤ 1μM |
| NMDE1_HUMAN | Q12879 | Glutamate [NMDA] Receptor Subunit Epsilon 1, Human | 177 | 0.79 | Binding ≤ 1μM |
| NMDE2_RAT | Q00960 | Glutamate [NMDA] Receptor Subunit Epsilon 2, Rat | 176 | 0.79 | Binding ≤ 1μM |
| NMDE2_HUMAN | Q13224 | Glutamate [NMDA] Receptor Subunit Epsilon 2, Human | 177 | 0.79 | Binding ≤ 1μM |
| NMDE3_RAT | Q00961 | Glutamate [NMDA] Receptor Subunit Epsilon 3, Rat | 176 | 0.79 | Binding ≤ 1μM |
| NMDE3_HUMAN | Q14957 | Glutamate [NMDA] Receptor Subunit Epsilon 3, Human | 177 | 0.79 | Binding ≤ 1μM |
| NMDE4_HUMAN | O15399 | Glutamate [NMDA] Receptor Subunit Epsilon 4, Human | 177 | 0.79 | Binding ≤ 1μM |
| NMDE4_RAT | Q62645 | Glutamate [NMDA] Receptor Subunit Epsilon 4, Rat | 176 | 0.79 | Binding ≤ 1μM |
| NMDZ1_HUMAN | Q05586 | Glutamate (NMDA) Receptor Subunit Zeta 1, Human | 177 | 0.79 | Binding ≤ 10μM |
| NMDZ1_RAT | P35439 | Glutamate (NMDA) Receptor Subunit Zeta 1, Rat | 1640 | 0.67 | Binding ≤ 10μM |
| Z104302 | Z104302 | Glutamate NMDA Receptor | 1000 | 0.70 | Binding ≤ 10μM |
| NMD3A_HUMAN | Q8TCU5 | Glutamate [NMDA] Receptor Subunit 3A, Human | 177 | 0.79 | Binding ≤ 10μM |
| NMD3B_HUMAN | O60391 | Glutamate [NMDA] Receptor Subunit 3B, Human | 177 | 0.79 | Binding ≤ 10μM |
| NMDE1_HUMAN | Q12879 | Glutamate [NMDA] Receptor Subunit Epsilon 1, Human | 177 | 0.79 | Binding ≤ 10μM |
| NMDE1_RAT | Q00959 | Glutamate [NMDA] Receptor Subunit Epsilon 1, Rat | 176 | 0.79 | Binding ≤ 10μM |
| NMDE2_HUMAN | Q13224 | Glutamate [NMDA] Receptor Subunit Epsilon 2, Human | 177 | 0.79 | Binding ≤ 10μM |
| NMDE2_RAT | Q00960 | Glutamate [NMDA] Receptor Subunit Epsilon 2, Rat | 176 | 0.79 | Binding ≤ 10μM |
| NMDE3_RAT | Q00961 | Glutamate [NMDA] Receptor Subunit Epsilon 3, Rat | 176 | 0.79 | Binding ≤ 10μM |
| NMDE3_HUMAN | Q14957 | Glutamate [NMDA] Receptor Subunit Epsilon 3, Human | 177 | 0.79 | Binding ≤ 10μM |
| NMDE4_HUMAN | O15399 | Glutamate [NMDA] Receptor Subunit Epsilon 4, Human | 177 | 0.79 | Binding ≤ 10μM |
| NMDE4_RAT | Q62645 | Glutamate [NMDA] Receptor Subunit Epsilon 4, Rat | 176 | 0.79 | Binding ≤ 10μM |
| Z50597 | Z50597 | Rattus Norvegicus | 5500 | 0.61 | Functional ≤ 10μM |
| Description | Species |
|---|---|
| CREB phosphorylation through the activation of CaMKII | |
| EPHB-mediated forward signaling | |
| Ras activation uopn Ca2+ infux through NMDA receptor | |
| Unblocking of NMDA receptor, glutamate binding and activation |
