UCSF

ZINC21288966

Draw Identity 99% 90% 80% 70%

Substance Information

In ZINC since Heavy atoms Benign functionality
December 3rd, 2008 28 Yes

Popular Name: Flavopiridol Flavopiridol

Find On: PubMed — Wikipedia — Google

CAS Numbers: 131740-09-5 , 146426-40-6

Other Names:

(-)cis-5,7-Dihydroxy-2-(2-chlorophenyl)-8-(4-(3-hydroxy-1-methyl)piperidinyl)-4H-1-benzopyran-4-one

(-)cis-5,7-Dihydroxy-2-(2-chlorophenyl)-8-(4-(3-hydroxy-1-methyl)piperidinyl)-4H-1-benzopyran-4-one; 4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5,7-dihydroxy-8-((3R,4S)-3-hydroxy-1-methyl-4-piperidinyl)-, rel-(-)-; 4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)

131740-09-5

131740-09-5; Alvocidib hydrochloride (USAN); D02880

146426-40-6

146426-40-6; Alvocidib (USAN/INN); D09868

1c8k

1e1y

2-(2-CHLORO-PHENYL)-5,7-DIHYDROXY-8-(3-HYDROXY-1-METHYL-PIPERIDIN-4-YL)-4H-BENZOPYRAN-4-ONE

2-(2-Chlorophenyl)-5,7-dihydroxy-8-((3S,4R)-3-hydroxy-1-methylpiperidin-4-yl)-4H-chromen-4-one

2-(2-chlorophenyl)-5,7-dihydroxy-8-(3-hydroxy-1-methyl-4-piperidinyl)-4H-chromen-4-one hydrochloride; nsc649890

2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]chromen-4-one

358739-39-6

4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-2,3-dihydro-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-

4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5,7-dihydroxy-8-((3R,4S)-3-hydroxy-1-methyl-4-piperidinyl)-, rel-(-)-

4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5,7-dihydroxy-8-(3-hydroxy-1-methyl-4-piperidinyl)-, cis-(-)-

AC1NRALK

Alvocidib

Alvocidib (INN

Alvocidib [INN]

C21H20ClNO5

CHEMBL428690

CHEMBL8817

CID5287969

CPB

DB03496

DCL000422

Flavo

Flavopiridol (Alvocidib) HCl

Flavopiridol hydrochloride

HL 275

HL-275

HL-275; HMR-1275; L-86-8275; MDL-107826A; NSC-649890

HL-275; HMR-1275; L-868275; L-86-8275; MDL-107826A; NSC-649890

HL-275; HMR-1275; L86-8275; MDL-107826A; NSC-649890; L-86-8275

HMR 1275

HMR-1275

HMR-1275, Alvocidib, L868275, Flavopiridol

L 86 8275

L 868275

L-868275

L86-8275

LS-173272

MDL-107826A

N/A

NSC-649890

NSC649890

S1230_Selleck

UNII-45AD6X575G

USAN); Alvocidib HCl (USAN)

USAN); Alvocidib Hydrochloride (USAN)

Download: MOL2 SDF SMILES Flexibase

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.46 7.04 -50.59 4 6 1 95 402.854 2 ↓
Hi High (pH 8-9.5) 3.46 7.74 -91.2 3 6 0 98 401.846 2 ↓

Vendor Notes

Note Type Comments Provided By
ALOGPS_SOLUBILITY 9.40e-02 g/l DrugBank-experimental
Target CDK Selleck Chemicals
PUBCHEM_PATENT_ID EP0150999A2; EP0150999B1; EP0167248A2; EP0167248B1; EP0170446A1; EP0170446B1; EP0222279A2; EP0244932A2; EP0257052A1; EP0338439A1; EP0338440A1; EP0343696A2; EP0395124A1; EP0874847A1; EP0888458A1; EP0912535A1; EP0914116A1; EP0914116B1; EP0919244A2; EP095538 IBM Patent Data

Activity (Go SEA)

Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
AAK1-1-E Adaptor-associated Kinase (cluster #1 Of 2), Eukaryotic Eukaryotes 5300 0.26 Binding ≤ 10μM
AAPK1-1-E AMP-activated Protein Kinase, Alpha-1 Subunit (cluster #1 Of 1), Eukaryotic Eukaryotes 6600 0.26 Binding ≤ 10μM
ACVR1-1-E Activin Receptor Type-1 (cluster #1 Of 1), Eukaryotic Eukaryotes 1900 0.29 Binding ≤ 10μM
ALK-1-E ALK Tyrosine Kinase Receptor (cluster #1 Of 1), Eukaryotic Eukaryotes 670 0.31 Binding ≤ 10μM
AVR2B-1-E Activin Receptor Type-2B (cluster #1 Of 1), Eukaryotic Eukaryotes 2400 0.28 Binding ≤ 10μM
CCNA1-1-E Cyclin A1 (cluster #1 Of 3), Eukaryotic Eukaryotes 70 0.36 Binding ≤ 10μM
CCNA2-1-E Cyclin A2 (cluster #1 Of 3), Eukaryotic Eukaryotes 70 0.36 Binding ≤ 10μM
CCNB-1-E G2/mitotic-specific Cyclin B (cluster #1 Of 1), Eukaryotic Eukaryotes 400 0.32 Binding ≤ 10μM
CCNB1-1-E G2/mitotic-specific Cyclin B1 (cluster #1 Of 2), Eukaryotic Eukaryotes 520 0.31 Binding ≤ 10μM
CCNB2-1-E G2/mitotic-specific Cyclin B2 (cluster #1 Of 2), Eukaryotic Eukaryotes 520 0.31 Binding ≤ 10μM
CCNB3-1-E G2/mitotic-specific Cyclin B3 (cluster #1 Of 2), Eukaryotic Eukaryotes 520 0.31 Binding ≤ 10μM
CCND1-1-E G1/S-specific Cyclin D1 (cluster #1 Of 1), Eukaryotic Eukaryotes 100 0.35 Binding ≤ 10μM
CCND2-1-E G1/S-specific Cyclin D2 (cluster #1 Of 1), Eukaryotic Eukaryotes 100 0.35 Binding ≤ 10μM
CCND3-1-E G1/S-specific Cyclin D3 (cluster #1 Of 1), Eukaryotic Eukaryotes 100 0.35 Binding ≤ 10μM
CCNE1-1-E G1/S-specific Cyclin E1 (cluster #1 Of 2), Eukaryotic Eukaryotes 960 0.30 Binding ≤ 10μM
CCNE2-1-E G1/S-specific Cyclin E2 (cluster #1 Of 2), Eukaryotic Eukaryotes 960 0.30 Binding ≤ 10μM
CCNH-1-E Cyclin H (cluster #1 Of 1), Eukaryotic Eukaryotes 400 0.32 Binding ≤ 10μM
CDK1-1-E Cyclin-dependent Kinase 1 (cluster #1 Of 4), Eukaryotic Eukaryotes 520 0.31 Binding ≤ 10μM
CDK14-1-E Serine/threonine-protein Kinase PFTAIRE-1 (cluster #1 Of 1), Eukaryotic Eukaryotes 110 0.35 Binding ≤ 10μM
CDK16-1-E Serine/threonine-protein Kinase PCTAIRE-1 (cluster #1 Of 1), Eukaryotic Eukaryotes 440 0.32 Binding ≤ 10μM
CDK17-1-E Serine/threonine-protein Kinase PCTAIRE-2 (cluster #1 Of 1), Eukaryotic Eukaryotes 480 0.32 Binding ≤ 10μM
CDK18-1-E Serine/threonine-protein Kinase PCTAIRE-3 (cluster #1 Of 1), Eukaryotic Eukaryotes 1100 0.30 Binding ≤ 10μM
CDK19-1-E Cell Division Cycle 2-like Protein Kinase 6 (cluster #1 Of 1), Eukaryotic Eukaryotes 57 0.36 Binding ≤ 10μM
CDK2-1-E Cyclin-dependent Kinase 2 (cluster #1 Of 5), Eukaryotic Eukaryotes 960 0.30 Binding ≤ 10μM
CDK3-1-E Cyclin-dependent Kinase 3 (cluster #1 Of 1), Eukaryotic Eukaryotes 410 0.32 Binding ≤ 10μM
CDK4-2-E Cyclin-dependent Kinase 4 (cluster #2 Of 3), Eukaryotic Eukaryotes 100 0.35 Binding ≤ 10μM
CDK5-1-E Cyclin-dependent Kinase 5 (cluster #1 Of 1), Eukaryotic Eukaryotes 43 0.37 Binding ≤ 10μM
CDK6-1-E Cyclin-dependent Kinase 6 (cluster #1 Of 1), Eukaryotic Eukaryotes 80 0.35 Binding ≤ 10μM
CDK7-1-E Cyclin-dependent Kinase 7 (cluster #1 Of 1), Eukaryotic Eukaryotes 875 0.30 Binding ≤ 10μM
CDK8-1-E Cell Division Protein Kinase 8 (cluster #1 Of 1), Eukaryotic Eukaryotes 120 0.35 Binding ≤ 10μM
CDK9-1-E Cyclin-dependent Kinase 9 (cluster #1 Of 2), Eukaryotic Eukaryotes 6 0.41 Binding ≤ 10μM
CLK1-1-E Dual Specificty Protein Kinase CLK1 (cluster #1 Of 2), Eukaryotic Eukaryotes 2200 0.28 Binding ≤ 10μM
CLK2-1-E Dual Specificity Protein Kinase CLK2 (cluster #1 Of 2), Eukaryotic Eukaryotes 2200 0.28 Binding ≤ 10μM
CLK3-1-E Dual Specificity Protein Kinase CLK3 (cluster #1 Of 1), Eukaryotic Eukaryotes 1600 0.29 Binding ≤ 10μM
CSF1R-1-E Macrophage Colony-stimulating Factor 1 Receptor (cluster #1 Of 1), Eukaryotic Eukaryotes 2800 0.28 Binding ≤ 10μM
CTRO-1-E Citron Rho-interacting Kinase (cluster #1 Of 1), Eukaryotic Eukaryotes 110 0.35 Binding ≤ 10μM
DCLK1-1-E Serine/threonine-protein Kinase DCLK1 (cluster #1 Of 1), Eukaryotic Eukaryotes 2100 0.28 Binding ≤ 10μM
DCLK3-1-E Serine/threonine-protein Kinase DCLK3 (cluster #1 Of 1), Eukaryotic Eukaryotes 1100 0.30 Binding ≤ 10μM
DMPK-1-E Myotonin-protein Kinase (cluster #1 Of 1), Eukaryotic Eukaryotes 650 0.31 Binding ≤ 10μM
DYR1B-1-E Dual Specificity Tyrosine-phosphorylation-regulated Kinase 1B (cluster #1 Of 1), Eukaryotic Eukaryotes 84 0.35 Binding ≤ 10μM
E2AK2-1-E Interferon-induced, Double-stranded RNA-activated Protein Kinase (cluster #1 Of 1), Eukaryotic Eukaryotes 5200 0.26 Binding ≤ 10μM
EGFR-2-E Epidermal Growth Factor Receptor ErbB1 (cluster #2 Of 4), Eukaryotic Eukaryotes 7600 0.26 Binding ≤ 10μM
EPHA2-1-E Ephrin Type-A Receptor 2 (cluster #1 Of 1), Eukaryotic Eukaryotes 2500 0.28 Binding ≤ 10μM
EPHA3-1-E Ephrin Type-A Receptor 3 (cluster #1 Of 2), Eukaryotic Eukaryotes 3300 0.27 Binding ≤ 10μM
EPHA5-1-E Ephrin Type-A Receptor 5 (cluster #1 Of 1), Eukaryotic Eukaryotes 4000 0.27 Binding ≤ 10μM
EPHB1-1-E Ephrin Type-B Receptor 1 (cluster #1 Of 1), Eukaryotic Eukaryotes 2200 0.28 Binding ≤ 10μM
FLT3-1-E Tyrosine-protein Kinase Receptor FLT3 (cluster #1 Of 1), Eukaryotic Eukaryotes 6500 0.26 Binding ≤ 10μM
GAK-1-E Serine/threonine-protein Kinase GAK (cluster #1 Of 2), Eukaryotic Eukaryotes 370 0.32 Binding ≤ 10μM
GSK3A-1-E Glycogen Synthase Kinase-3 Alpha (cluster #1 Of 3), Eukaryotic Eukaryotes 1300 0.29 Binding ≤ 10μM
GSK3B-7-E Glycogen Synthase Kinase-3 Beta (cluster #7 Of 7), Eukaryotic Eukaryotes 730 0.31 Binding ≤ 10μM
IKKE-1-E Inhibitor Of Nuclear Factor Kappa B Kinase Epsilon Subunit (cluster #1 Of 1), Eukaryotic Eukaryotes 3100 0.28 Binding ≤ 10μM
KCC2A-1-E CaM Kinase II Alpha (cluster #1 Of 1), Eukaryotic Eukaryotes 1700 0.29 Binding ≤ 10μM
KCC2B-1-E CaM Kinase II Beta (cluster #1 Of 1), Eukaryotic Eukaryotes 2600 0.28 Binding ≤ 10μM
KCC4-1-E CaM Kinase IV (cluster #1 Of 1), Eukaryotic Eukaryotes 3200 0.27 Binding ≤ 10μM
KIT-1-E Stem Cell Growth Factor Receptor (cluster #1 Of 1), Eukaryotic Eukaryotes 4600 0.27 Binding ≤ 10μM
KKCC1-1-E CaM-kinase Kinase Alpha (cluster #1 Of 1), Eukaryotic Eukaryotes 79 0.36 Binding ≤ 10μM
KKCC2-1-E CaM-kinase Kinase Beta (cluster #1 Of 2), Eukaryotic Eukaryotes 430 0.32 Binding ≤ 10μM
KPCA-1-E Protein Kinase C Alpha (cluster #1 Of 6), Eukaryotic Eukaryotes 2800 0.28 Binding ≤ 10μM
KPCB-1-E Protein Kinase C Beta (cluster #1 Of 4), Eukaryotic Eukaryotes 10000 0.25 Binding ≤ 10μM
KPCD-1-E Protein Kinase C Delta (cluster #1 Of 4), Eukaryotic Eukaryotes 890 0.30 Binding ≤ 10μM
KPCD1-1-E Protein Kinase C Mu (cluster #1 Of 3), Eukaryotic Eukaryotes 520 0.31 Binding ≤ 10μM
KPCD2-1-E Serine/threonine-protein Kinase D2 (cluster #1 Of 1), Eukaryotic Eukaryotes 1100 0.30 Binding ≤ 10μM
KPCD3-1-E Protein Kinase C Nu (cluster #1 Of 3), Eukaryotic Eukaryotes 170 0.34 Binding ≤ 10μM
KPCE-1-E Protein Kinase C Epsilon (cluster #1 Of 5), Eukaryotic Eukaryotes 480 0.32 Binding ≤ 10μM
KPCG-1-E Protein Kinase C Gamma (cluster #1 Of 4), Eukaryotic Eukaryotes 10000 0.25 Binding ≤ 10μM
KPCI-1-E Protein Kinase C Iota (cluster #1 Of 3), Eukaryotic Eukaryotes 10000 0.25 Binding ≤ 10μM
KPCL-2-E Protein Kinase C Eta (cluster #2 Of 4), Eukaryotic Eukaryotes 350 0.32 Binding ≤ 10μM
KPCT-1-E Protein Kinase C Theta (cluster #1 Of 3), Eukaryotic Eukaryotes 350 0.32 Binding ≤ 10μM
KPCZ-1-E Protein Kinase C Zeta (cluster #1 Of 5), Eukaryotic Eukaryotes 10000 0.25 Binding ≤ 10μM
KS6A1-1-E Ribosomal Protein S6 Kinase Alpha 1 (cluster #1 Of 1), Eukaryotic Eukaryotes 720 0.31 Binding ≤ 10μM
KS6A2-1-E Ribosomal Protein S6 Kinase Alpha 2 (cluster #1 Of 2), Eukaryotic Eukaryotes 1600 0.29 Binding ≤ 10μM
KS6A4-1-E Ribosomal Protein S6 Kinase Alpha 4 (cluster #1 Of 1), Eukaryotic Eukaryotes 1300 0.29 Binding ≤ 10μM
KS6A5-1-E Ribosomal Protein S6 Kinase Alpha 5 (cluster #1 Of 3), Eukaryotic Eukaryotes 2000 0.28 Binding ≤ 10μM
KS6A6-1-E Ribosomal Protein S6 Kinase Alpha 6 (cluster #1 Of 1), Eukaryotic Eukaryotes 800 0.30 Binding ≤ 10μM
LTK-1-E Leukocyte Tyrosine Kinase Receptor (cluster #1 Of 1), Eukaryotic Eukaryotes 2200 0.28 Binding ≤ 10μM
M3K10-1-E Mitogen-activated Protein Kinase Kinase Kinase 10 (cluster #1 Of 1), Eukaryotic Eukaryotes 5200 0.26 Binding ≤ 10μM
M3K9-1-E Mitogen-activated Protein Kinase Kinase Kinase 9 (cluster #1 Of 1), Eukaryotic Eukaryotes 5700 0.26 Binding ≤ 10μM
M4K1-1-E Mitogen-activated Protein Kinase Kinase Kinase Kinase 1 (cluster #1 Of 1), Eukaryotic Eukaryotes 3300 0.27 Binding ≤ 10μM
M4K3-1-E Mitogen-activated Protein Kinase Kinase Kinase Kinase 3 (cluster #1 Of 1), Eukaryotic Eukaryotes 4500 0.27 Binding ≤ 10μM
MERTK-1-E Proto-oncogene Tyrosine-protein Kinase MER (cluster #1 Of 1), Eukaryotic Eukaryotes 6800 0.26 Binding ≤ 10μM
MK07-1-E Mitogen-activated Protein Kinase 7 (cluster #1 Of 1), Eukaryotic Eukaryotes 620 0.31 Binding ≤ 10μM
MK10-1-E C-Jun N-terminal Kinase 3 (cluster #1 Of 2), Eukaryotic Eukaryotes 5500 0.26 Binding ≤ 10μM
MK15-1-E Mitogen-activated Protein Kinase 15 (cluster #1 Of 1), Eukaryotic Eukaryotes 330 0.32 Binding ≤ 10μM
MKNK2-1-E MAP Kinase Signal-integrating Kinase 2 (cluster #1 Of 2), Eukaryotic Eukaryotes 3200 0.27 Binding ≤ 10μM
MRCKA-1-E Serine/threonine-protein Kinase MRCK-A (cluster #1 Of 1), Eukaryotic Eukaryotes 9500 0.25 Binding ≤ 10μM
MRCKB-1-E Serine/threonine-protein Kinase MRCK Beta (cluster #1 Of 1), Eukaryotic Eukaryotes 3300 0.27 Binding ≤ 10μM
NUAK2-1-E NUAK Family SNF1-like Kinase 2 (cluster #1 Of 1), Eukaryotic Eukaryotes 1400 0.29 Binding ≤ 10μM
PHKG1-1-E Phosphorylase Kinase Gamma Subunit 1 (cluster #1 Of 2), Eukaryotic Eukaryotes 2200 0.28 Binding ≤ 10μM
PHKG2-1-E Phosphorylase Kinase Gamma Subunit 2 (cluster #1 Of 2), Eukaryotic Eukaryotes 2900 0.28 Binding ≤ 10μM
PIM1-1-E Serine/threonine-protein Kinase PIM1 (cluster #1 Of 1), Eukaryotic Eukaryotes 560 0.31 Binding ≤ 10μM
PIM2-1-E Serine/threonine-protein Kinase PIM2 (cluster #1 Of 2), Eukaryotic Eukaryotes 770 0.31 Binding ≤ 10μM
PIM3-1-E Serine/threonine-protein Kinase PIM3 (cluster #1 Of 1), Eukaryotic Eukaryotes 600 0.31 Binding ≤ 10μM
PKN1-1-E Protein Kinase N1 (cluster #1 Of 1), Eukaryotic Eukaryotes 3500 0.27 Binding ≤ 10μM
PLK4-1-E Serine/threonine-protein Kinase PLK4 (cluster #1 Of 1), Eukaryotic Eukaryotes 3100 0.28 Binding ≤ 10μM
PYGM-2-E Muscle Glycogen Phosphorylase (cluster #2 Of 4), Eukaryotic Eukaryotes 1000 0.30 Binding ≤ 10μM
SRMS-1-E Tyrosine-protein Kinase Srms (cluster #1 Of 1), Eukaryotic Eukaryotes 1400 0.29 Binding ≤ 10μM
ST17B-1-E Serine/threonine-protein Kinase 17B (cluster #1 Of 1), Eukaryotic Eukaryotes 5100 0.26 Binding ≤ 10μM
STK3-1-E Serine/threonine-protein Kinase MST2 (cluster #1 Of 2), Eukaryotic Eukaryotes 9400 0.25 Binding ≤ 10μM
STK33-1-E Serine/threonine-protein Kinase 33 (cluster #1 Of 1), Eukaryotic Eukaryotes 1700 0.29 Binding ≤ 10μM
TGFR2-1-E TGF-beta Receptor Type II (cluster #1 Of 1), Eukaryotic Eukaryotes 5600 0.26 Binding ≤ 10μM
TNI3K-1-E Serine/threonine-protein Kinase TNNI3K (cluster #1 Of 1), Eukaryotic Eukaryotes 55 0.36 Binding ≤ 10μM
UFO-1-E Tyrosine-protein Kinase Receptor UFO (cluster #1 Of 1), Eukaryotic Eukaryotes 3500 0.27 Binding ≤ 10μM
Z104294-2-O Cyclin-dependent Kinase 5/CDK5 Activator 1 (cluster #2 Of 2), Other Other 170 0.34 Binding ≤ 10μM
Z104295-1-O Cyclin-dependent Kinase 4/cyclin D1 (cluster #1 Of 2), Other Other 90 0.35 Binding ≤ 10μM
Z104295-1-O Cyclin-dependent Kinase 4/cyclin D1 (cluster #1 Of 2), Other Other 100 0.35 Binding ≤ 10μM
Z104296-1-O Cyclin-dependent Kinase 1/cyclin B1 (cluster #1 Of 2), Other Other 30 0.38 Binding ≤ 10μM
Z100090-1-O ABAE (Fibroblast Cells) (cluster #1 Of 1), Other Other 45 0.37 Functional ≤ 10μM
Z100091-1-O HS27 (Fibroblast Cells) (cluster #1 Of 1), Other Other 51 0.36 Functional ≤ 10μM
Z100093-1-O LX-1 (Lung Carcinoma Cells) (cluster #1 Of 1), Other Other 75 0.36 Functional ≤ 10μM
Z100094-1-O MLF (Lung Fibroblast Cells) (cluster #1 Of 1), Other Other 72 0.36 Functional ≤ 10μM
Z100095-1-O MIP (Colon Carcinoma Cells) (cluster #1 Of 1), Other Other 120 0.35 Functional ≤ 10μM
Z80054-1-O Caco-2 (Colon Adenocarcinoma Cells) (cluster #1 Of 4), Other Other 86 0.35 Functional ≤ 10μM
Z80064-1-O CCRF-CEM (T-cell Leukemia) (cluster #1 Of 9), Other Other 52 0.36 Functional ≤ 10μM
Z80156-2-O HL-60 (Promyeloblast Leukemia Cells) (cluster #2 Of 12), Other Other 46 0.37 Functional ≤ 10μM
Z80186-9-O K562 (Erythroleukemia Cells) (cluster #9 Of 11), Other Other 130 0.34 Functional ≤ 10μM
Z80224-1-O MCF7 (Breast Carcinoma Cells) (cluster #1 Of 14), Other Other 66 0.36 Functional ≤ 10μM
Z80354-4-O OVCAR-3 (Ovarian Adenocarcinoma Cells) (cluster #4 Of 4), Other Other 54 0.36 Functional ≤ 10μM
Z80390-1-O PC-3 (Prostate Carcinoma Cells) (cluster #1 Of 10), Other Other 66 0.36 Functional ≤ 10μM
Z80475-1-O SK-BR-3 (Breast Adenocarcinoma) (cluster #1 Of 3), Other Other 77 0.36 Functional ≤ 10μM
Z80675-1-O AG1523 (Fibroblast Cells) (cluster #1 Of 1), Other Other 6700 0.26 Functional ≤ 10μM
Z80682-1-O A549 (Lung Carcinoma Cells) (cluster #1 Of 11), Other Other 96 0.35 Functional ≤ 10μM
Z80852-2-O A-431 (Epidermoid Carcinoma Cells) (cluster #2 Of 3), Other Other 75 0.36 Functional ≤ 10μM
Z80928-1-O HCT-116 (Colon Carcinoma Cells) (cluster #1 Of 9), Other Other 490 0.32 Functional ≤ 10μM
Z81034-1-O A2780 (Ovarian Carcinoma Cells) (cluster #1 Of 10), Other Other 78 0.36 Functional ≤ 10μM
Z81170-1-O LNCaP (Prostate Carcinoma) (cluster #1 Of 5), Other Other 16 0.39 Functional ≤ 10μM
Z81186-1-O LS174T (Colon Adencocarcinoma Cells) (cluster #1 Of 2), Other Other 65 0.36 Functional ≤ 10μM
Z81225-1-O M109 (Lung Carcinoma Cells) (cluster #1 Of 2), Other Other 80 0.35 Functional ≤ 10μM
ChEMBL Target Annotations
Uniprot Swissprot Description Affinity (nM) LE (kcal/mol/atom) Type
ALK_HUMAN Q9UM73 ALK Tyrosine Kinase Receptor, Human 670 0.31 Binding ≤ 1μM
KKCC1_HUMAN Q8N5S9 CaM-kinase Kinase Alpha, Human 19 0.39 Binding ≤ 1μM
KKCC2_HUMAN Q96RR4 CaM-kinase Kinase Beta, Human 320 0.32 Binding ≤ 1μM
CDK19_HUMAN Q9BWU1 Cell Division Cycle 2-like Protein Kinase 6, Human 57 0.36 Binding ≤ 1μM
CDK8_HUMAN P49336 Cell Division Protein Kinase 8, Human 120 0.35 Binding ≤ 1μM
CTRO_HUMAN O14578 Citron Rho-interacting Kinase, Human 110 0.35 Binding ≤ 1μM
CCNA1_HUMAN P78396 Cyclin A1, Human 50 0.37 Binding ≤ 1μM
CCNA2_HUMAN P20248 Cyclin A2, Human 50 0.37 Binding ≤ 1μM
CCNH_HUMAN P51946 Cyclin H, Human 400 0.32 Binding ≤ 1μM
CDK1_HUMAN P06493 Cyclin-dependent Kinase 1, Human 210 0.33 Binding ≤ 1μM
Z104296 Z104296 Cyclin-dependent Kinase 1/cyclin B1 200 0.33 Binding ≤ 1μM
CDK2_HUMAN P24941 Cyclin-dependent Kinase 2, Human 170 0.34 Binding ≤ 1μM
CDK3_HUMAN Q00526 Cyclin-dependent Kinase 3, Human 410 0.32 Binding ≤ 1μM
CDK4_HUMAN P11802 Cyclin-dependent Kinase 4, Human 100 0.35 Binding ≤ 1μM
Z104295 Z104295 Cyclin-dependent Kinase 4/cyclin D1 100 0.35 Binding ≤ 1μM
CDK5_HUMAN Q00535 Cyclin-dependent Kinase 5, Human 110 0.35 Binding ≤ 1μM
Z104294 Z104294 Cyclin-dependent Kinase 5/CDK5 Activator 1 170 0.34 Binding ≤ 1μM
CDK6_HUMAN Q00534 Cyclin-dependent Kinase 6, Human 80 0.35 Binding ≤ 1μM
CDK7_HUMAN P50613 Cyclin-dependent Kinase 7, Human 23 0.38 Binding ≤ 1μM
CDK9_HUMAN P50750 Cyclin-dependent Kinase 9, Human 20 0.38 Binding ≤ 1μM
CLK3_HUMAN P49761 Dual Specificity Protein Kinase CLK3, Human 1000 0.30 Binding ≤ 1μM
DYR1B_HUMAN Q9Y463 Dual Specificity Tyrosine-phosphorylation-regulated Kinase 1B, Human 84 0.35 Binding ≤ 1μM
CCND1_HUMAN P24385 G1/S-specific Cyclin D1, Human 100 0.35 Binding ≤ 1μM
CCND2_HUMAN P30279 G1/S-specific Cyclin D2, Human 100 0.35 Binding ≤ 1μM
CCND3_HUMAN P30281 G1/S-specific Cyclin D3, Human 100 0.35 Binding ≤ 1μM
CCNE1_HUMAN P24864 G1/S-specific Cyclin E1, Human 170 0.34 Binding ≤ 1μM
CCNE2_HUMAN O96020 G1/S-specific Cyclin E2, Human 170 0.34 Binding ≤ 1μM
CCNB_MARGL P15206 G2/mitotic-specific Cyclin B, Margl 400 0.32 Binding ≤ 1μM
CCNB1_HUMAN P14635 G2/mitotic-specific Cyclin B1, Human 210 0.33 Binding ≤ 1μM
CCNB2_HUMAN O95067 G2/mitotic-specific Cyclin B2, Human 210 0.33 Binding ≤ 1μM
CCNB3_HUMAN Q8WWL7 G2/mitotic-specific Cyclin B3, Human 210 0.33 Binding ≤ 1μM
GSK3A_HUMAN P49840 Glycogen Synthase Kinase-3 Alpha, Human 280 0.33 Binding ≤ 1μM
GSK3B_HUMAN P49841 Glycogen Synthase Kinase-3 Beta, Human 280 0.33 Binding ≤ 1μM
MK15_HUMAN Q8TD08 Mitogen-activated Protein Kinase 15, Human 330 0.32 Binding ≤ 1μM
MK07_HUMAN Q13164 Mitogen-activated Protein Kinase 7, Human 620 0.31 Binding ≤ 1μM
PYGM_HUMAN P11217 Muscle Glycogen Phosphorylase, Human 1000 0.30 Binding ≤ 1μM
DMPK_HUMAN Q09013 Myotonin-protein Kinase, Human 650 0.31 Binding ≤ 1μM
KPCD_HUMAN Q05655 Protein Kinase C Delta, Human 590 0.31 Binding ≤ 1μM
KPCE_HUMAN Q02156 Protein Kinase C Epsilon, Human 380 0.32 Binding ≤ 1μM
KPCL_HUMAN P24723 Protein Kinase C Eta, Human 350 0.32 Binding ≤ 1μM
KPCD1_HUMAN Q15139 Protein Kinase C Mu, Human 520 0.31 Binding ≤ 1μM
KPCD3_HUMAN O94806 Protein Kinase C Nu, Human 170 0.34 Binding ≤ 1μM
KPCT_HUMAN Q04759 Protein Kinase C Theta, Human 350 0.32 Binding ≤ 1μM
KS6A1_HUMAN Q15418 Ribosomal Protein S6 Kinase Alpha 1, Human 720 0.31 Binding ≤ 1μM
KS6A6_HUMAN Q9UK32 Ribosomal Protein S6 Kinase Alpha 6, Human 800 0.30 Binding ≤ 1μM
GAK_HUMAN O14976 Serine/threonine-protein Kinase GAK, Human 370 0.32 Binding ≤ 1μM
CDK16_HUMAN Q00536 Serine/threonine-protein Kinase PCTAIRE-1, Human 180 0.34 Binding ≤ 1μM
CDK17_HUMAN Q00537 Serine/threonine-protein Kinase PCTAIRE-2, Human 480 0.32 Binding ≤ 1μM
CDK14_HUMAN O94921 Serine/threonine-protein Kinase PFTAIRE-1, Human 110 0.35 Binding ≤ 1μM
PIM1_HUMAN P11309 Serine/threonine-protein Kinase PIM1, Human 520 0.31 Binding ≤ 1μM
PIM2_HUMAN Q9P1W9 Serine/threonine-protein Kinase PIM2, Human 650 0.31 Binding ≤ 1μM
PIM3_HUMAN Q86V86 Serine/threonine-protein Kinase PIM3, Human 600 0.31 Binding ≤ 1μM
TNI3K_HUMAN Q59H18 Serine/threonine-protein Kinase TNNI3K, Human 55 0.36 Binding ≤ 1μM
ACVR1_HUMAN Q04771 Activin Receptor Type-1, Human 1900 0.29 Binding ≤ 10μM
AVR2B_HUMAN Q13705 Activin Receptor Type-2B, Human 2400 0.28 Binding ≤ 10μM
AAK1_HUMAN Q2M2I8 Adaptor-associated Kinase, Human 5300 0.26 Binding ≤ 10μM
ALK_HUMAN Q9UM73 ALK Tyrosine Kinase Receptor, Human 670 0.31 Binding ≤ 10μM
AAPK1_HUMAN Q13131 AMP-activated Protein Kinase, Alpha-1 Subunit, Human 6600 0.26 Binding ≤ 10μM
MK10_HUMAN P53779 C-Jun N-terminal Kinase 3, Human 5500 0.26 Binding ≤ 10μM
KCC2A_HUMAN Q9UQM7 CaM Kinase II Alpha, Human 1300 0.29 Binding ≤ 10μM
KCC2B_HUMAN Q13554 CaM Kinase II Beta, Human 2600 0.28 Binding ≤ 10μM
KCC4_HUMAN Q16566 CaM Kinase IV, Human 3200 0.27 Binding ≤ 10μM
KKCC1_HUMAN Q8N5S9 CaM-kinase Kinase Alpha, Human 19 0.39 Binding ≤ 10μM
KKCC2_HUMAN Q96RR4 CaM-kinase Kinase Beta, Human 320 0.32 Binding ≤ 10μM
CDK19_HUMAN Q9BWU1 Cell Division Cycle 2-like Protein Kinase 6, Human 57 0.36 Binding ≤ 10μM
CDK8_HUMAN P49336 Cell Division Protein Kinase 8, Human 120 0.35 Binding ≤ 10μM
CTRO_HUMAN O14578 Citron Rho-interacting Kinase, Human 110 0.35 Binding ≤ 10μM
CCNA1_HUMAN P78396 Cyclin A1, Human 1500 0.29 Binding ≤ 10μM
CCNA2_HUMAN P20248 Cyclin A2, Human 1500 0.29 Binding ≤ 10μM
CCNH_HUMAN P51946 Cyclin H, Human 400 0.32 Binding ≤ 10μM
CDK1_HUMAN P06493 Cyclin-dependent Kinase 1, Human 210 0.33 Binding ≤ 10μM
Z104296 Z104296 Cyclin-dependent Kinase 1/cyclin B1 200 0.33 Binding ≤ 10μM
CDK2_HUMAN P24941 Cyclin-dependent Kinase 2, Human 1500 0.29 Binding ≤ 10μM
CDK3_HUMAN Q00526 Cyclin-dependent Kinase 3, Human 410 0.32 Binding ≤ 10μM
CDK4_HUMAN P11802 Cyclin-dependent Kinase 4, Human 100 0.35 Binding ≤ 10μM
Z104295 Z104295 Cyclin-dependent Kinase 4/cyclin D1 100 0.35 Binding ≤ 10μM
CDK5_HUMAN Q00535 Cyclin-dependent Kinase 5, Human 110 0.35 Binding ≤ 10μM
Z104294 Z104294 Cyclin-dependent Kinase 5/CDK5 Activator 1 170 0.34 Binding ≤ 10μM
CDK6_HUMAN Q00534 Cyclin-dependent Kinase 6, Human 80 0.35 Binding ≤ 10μM
CDK7_HUMAN P50613 Cyclin-dependent Kinase 7, Human 23 0.38 Binding ≤ 10μM
CDK9_HUMAN P50750 Cyclin-dependent Kinase 9, Human 20 0.38 Binding ≤ 10μM
CLK2_HUMAN P49760 Dual Specificity Protein Kinase CLK2, Human 1400 0.29 Binding ≤ 10μM
CLK3_HUMAN P49761 Dual Specificity Protein Kinase CLK3, Human 1000 0.30 Binding ≤ 10μM
DYR1B_HUMAN Q9Y463 Dual Specificity Tyrosine-phosphorylation-regulated Kinase 1B, Human 84 0.35 Binding ≤ 10μM
CLK1_HUMAN P49759 Dual Specificty Protein Kinase CLK1, Human 1700 0.29 Binding ≤ 10μM
EPHA2_HUMAN P29317 Ephrin Type-A Receptor 2, Human 2500 0.28 Binding ≤ 10μM
EPHA3_HUMAN P29320 Ephrin Type-A Receptor 3, Human 3300 0.27 Binding ≤ 10μM
EPHA5_HUMAN P54756 Ephrin Type-A Receptor 5, Human 4000 0.27 Binding ≤ 10μM
EPHB1_HUMAN P54762 Ephrin Type-B Receptor 1, Human 2200 0.28 Binding ≤ 10μM
EGFR_HUMAN P00533 Epidermal Growth Factor Receptor ErbB1, Human 1400 0.29 Binding ≤ 10μM
CCND1_HUMAN P24385 G1/S-specific Cyclin D1, Human 100 0.35 Binding ≤ 10μM
CCND2_HUMAN P30279 G1/S-specific Cyclin D2, Human 100 0.35 Binding ≤ 10μM
CCND3_HUMAN P30281 G1/S-specific Cyclin D3, Human 100 0.35 Binding ≤ 10μM
CCNE1_HUMAN P24864 G1/S-specific Cyclin E1, Human 170 0.34 Binding ≤ 10μM
CCNE2_HUMAN O96020 G1/S-specific Cyclin E2, Human 170 0.34 Binding ≤ 10μM
CCNB_MARGL P15206 G2/mitotic-specific Cyclin B, Margl 400 0.32 Binding ≤ 10μM
CCNB1_HUMAN P14635 G2/mitotic-specific Cyclin B1, Human 210 0.33 Binding ≤ 10μM
CCNB2_HUMAN O95067 G2/mitotic-specific Cyclin B2, Human 210 0.33 Binding ≤ 10μM
CCNB3_HUMAN Q8WWL7 G2/mitotic-specific Cyclin B3, Human 210 0.33 Binding ≤ 10μM
GSK3A_HUMAN P49840 Glycogen Synthase Kinase-3 Alpha, Human 280 0.33 Binding ≤ 10μM
GSK3B_HUMAN P49841 Glycogen Synthase Kinase-3 Beta, Human 280 0.33 Binding ≤ 10μM
IKKE_HUMAN Q14164 Inhibitor Of Nuclear Factor Kappa B Kinase Epsilon Subunit, Human 3100 0.28 Binding ≤ 10μM
E2AK2_HUMAN P19525 Interferon-induced, Double-stranded RNA-activated Protein Kinase, Human 5200 0.26 Binding ≤ 10μM
LTK_HUMAN P29376 Leukocyte Tyrosine Kinase Receptor, Human 2200 0.28 Binding ≤ 10μM
CSF1R_HUMAN P07333 Macrophage Colony Stimulating Factor Receptor, Human 2800 0.28 Binding ≤ 10μM
MKNK2_HUMAN Q9HBH9 MAP Kinase Signal-integrating Kinase 2, Human 1900 0.29 Binding ≤ 10μM
MK15_HUMAN Q8TD08 Mitogen-activated Protein Kinase 15, Human 330 0.32 Binding ≤ 10μM
MK07_HUMAN Q13164 Mitogen-activated Protein Kinase 7, Human 620 0.31 Binding ≤ 10μM
M3K10_HUMAN Q02779 Mitogen-activated Protein Kinase Kinase Kinase 10, Human 5200 0.26 Binding ≤ 10μM
M3K9_HUMAN P80192 Mitogen-activated Protein Kinase Kinase Kinase 9, Human 5700 0.26 Binding ≤ 10μM
M4K1_HUMAN Q92918 Mitogen-activated Protein Kinase Kinase Kinase Kinase 1, Human 3300 0.27 Binding ≤ 10μM
M4K3_HUMAN Q8IVH8 Mitogen-activated Protein Kinase Kinase Kinase Kinase 3, Human 4500 0.27 Binding ≤ 10μM
PYGM_HUMAN P11217 Muscle Glycogen Phosphorylase, Human 1000 0.30 Binding ≤ 10μM
DMPK_HUMAN Q09013 Myotonin-protein Kinase, Human 650 0.31 Binding ≤ 10μM
NUAK2_HUMAN Q9H093 NUAK Family SNF1-like Kinase 2, Human 1400 0.29 Binding ≤ 10μM
PHKG1_HUMAN Q16816 Phosphorylase Kinase Gamma Subunit 1, Human 2200 0.28 Binding ≤ 10μM
PHKG2_HUMAN P15735 Phosphorylase Kinase Gamma Subunit 2, Human 2000 0.28 Binding ≤ 10μM
KPCA_HUMAN P17252 Protein Kinase C Alpha, Human 10000 0.25 Binding ≤ 10μM
KPCB_HUMAN P05771 Protein Kinase C Beta, Human 10000 0.25 Binding ≤ 10μM
KPCD_HUMAN Q05655 Protein Kinase C Delta, Human 10000 0.25 Binding ≤ 10μM
KPCE_HUMAN Q02156 Protein Kinase C Epsilon, Human 10000 0.25 Binding ≤ 10μM
KPCL_HUMAN P24723 Protein Kinase C Eta, Human 10000 0.25 Binding ≤ 10μM
KPCG_HUMAN P05129 Protein Kinase C Gamma, Human 10000 0.25 Binding ≤ 10μM
KPCI_HUMAN P41743 Protein Kinase C Iota, Human 10000 0.25 Binding ≤ 10μM
KPCD1_HUMAN Q15139 Protein Kinase C Mu, Human 10000 0.25 Binding ≤ 10μM
KPCD3_HUMAN O94806 Protein Kinase C Nu, Human 10000 0.25 Binding ≤ 10μM
KPCT_HUMAN Q04759 Protein Kinase C Theta, Human 10000 0.25 Binding ≤ 10μM
KPCZ_HUMAN Q05513 Protein Kinase C Zeta, Human 10000 0.25 Binding ≤ 10μM
PKN1_HUMAN Q16512 Protein Kinase N1, Human 3500 0.27 Binding ≤ 10μM
MERTK_HUMAN Q12866 Proto-oncogene Tyrosine-protein Kinase MER, Human 6800 0.26 Binding ≤ 10μM
KS6A1_HUMAN Q15418 Ribosomal Protein S6 Kinase Alpha 1, Human 2300 0.28 Binding ≤ 10μM
KS6A2_HUMAN Q15349 Ribosomal Protein S6 Kinase Alpha 2, Human 1500 0.29 Binding ≤ 10μM
KS6A4_HUMAN O75676 Ribosomal Protein S6 Kinase Alpha 4, Human 1300 0.29 Binding ≤ 10μM
KS6A5_HUMAN O75582 Ribosomal Protein S6 Kinase Alpha 5, Human 2000 0.28 Binding ≤ 10μM
KS6A6_HUMAN Q9UK32 Ribosomal Protein S6 Kinase Alpha 6, Human 800 0.30 Binding ≤ 10μM
ST17B_HUMAN O94768 Serine/threonine-protein Kinase 17B, Human 1900 0.29 Binding ≤ 10μM
STK33_HUMAN Q9BYT3 Serine/threonine-protein Kinase 33, Human 1700 0.29 Binding ≤ 10μM
KPCD2_HUMAN Q9BZL6 Serine/threonine-protein Kinase D2, Human 1100 0.30 Binding ≤ 10μM
DCLK1_HUMAN O15075 Serine/threonine-protein Kinase DCLK1, Human 2100 0.28 Binding ≤ 10μM
DCLK3_HUMAN Q9C098 Serine/threonine-protein Kinase DCLK3, Human 1100 0.30 Binding ≤ 10μM
GAK_HUMAN O14976 Serine/threonine-protein Kinase GAK, Human 1100 0.30 Binding ≤ 10μM
MRCKB_HUMAN Q9Y5S2 Serine/threonine-protein Kinase MRCK Beta, Human 3300 0.27 Binding ≤ 10μM
MRCKA_HUMAN Q5VT25 Serine/threonine-protein Kinase MRCK-A, Human 9500 0.25 Binding ≤ 10μM
STK3_HUMAN Q13188 Serine/threonine-protein Kinase MST2, Human 9400 0.25 Binding ≤ 10μM
CDK16_HUMAN Q00536 Serine/threonine-protein Kinase PCTAIRE-1, Human 180 0.34 Binding ≤ 10μM
CDK17_HUMAN Q00537 Serine/threonine-protein Kinase PCTAIRE-2, Human 480 0.32 Binding ≤ 10μM
CDK18_HUMAN Q07002 Serine/threonine-protein Kinase PCTAIRE-3, Human 1100 0.30 Binding ≤ 10μM
CDK14_HUMAN O94921 Serine/threonine-protein Kinase PFTAIRE-1, Human 110 0.35 Binding ≤ 10μM
PIM1_HUMAN P11309 Serine/threonine-protein Kinase PIM1, Human 520 0.31 Binding ≤ 10μM
PIM2_HUMAN Q9P1W9 Serine/threonine-protein Kinase PIM2, Human 650 0.31 Binding ≤ 10μM
PIM3_HUMAN Q86V86 Serine/threonine-protein Kinase PIM3, Human 600 0.31 Binding ≤ 10μM
PLK4_HUMAN O00444 Serine/threonine-protein Kinase PLK4, Human 3100 0.28 Binding ≤ 10μM
TNI3K_HUMAN Q59H18 Serine/threonine-protein Kinase TNNI3K, Human 55 0.36 Binding ≤ 10μM
KIT_HUMAN P10721 Stem Cell Growth Factor Receptor, Human 4600 0.27 Binding ≤ 10μM
TGFR2_HUMAN P37173 TGF-beta Receptor Type II, Human 5600 0.26 Binding ≤ 10μM
FLT3_HUMAN P36888 Tyrosine-protein Kinase Receptor FLT3, Human 3200 0.27 Binding ≤ 10μM
UFO_HUMAN P30530 Tyrosine-protein Kinase Receptor UFO, Human 3500 0.27 Binding ≤ 10μM
SRMS_HUMAN Q9H3Y6 Tyrosine-protein Kinase Srms, Human 1400 0.29 Binding ≤ 10μM
Z80852 Z80852 A-431 (Epidermoid Carcinoma Cells) 75 0.36 Functional ≤ 10μM
Z81034 Z81034 A2780 (Ovarian Carcinoma Cells) 38 0.37 Functional ≤ 10μM
Z80682 Z80682 A549 (Lung Carcinoma Cells) 96 0.35 Functional ≤ 10μM
Z100090 Z100090 ABAE (Fibroblast Cells) 45 0.37 Functional ≤ 10μM
Z80675 Z80675 AG1523 (Fibroblast Cells) 6700 0.26 Functional ≤ 10μM
Z80054 Z80054 Caco-2 (Colon Adenocarcinoma Cells) 86 0.35 Functional ≤ 10μM
Z80064 Z80064 CCRF-CEM (T-cell Leukemia) 52 0.36 Functional ≤ 10μM
Z80928 Z80928 HCT-116 (Colon Carcinoma Cells) 17 0.39 Functional ≤ 10μM
Z80156 Z80156 HL-60 (Promyeloblast Leukemia Cells) 46 0.37 Functional ≤ 10μM
Z100091 Z100091 HS27 (Fibroblast Cells) 51 0.36 Functional ≤ 10μM
Z80186 Z80186 K562 (Erythroleukemia Cells) 130 0.34 Functional ≤ 10μM
Z81170 Z81170 LNCaP (Prostate Carcinoma) 16 0.39 Functional ≤ 10μM
Z81186 Z81186 LS174T (Colon Adencocarcinoma Cells) 65 0.36 Functional ≤ 10μM
Z100093 Z100093 LX-1 (Lung Carcinoma Cells) 75 0.36 Functional ≤ 10μM
Z81225 Z81225 M109 (Lung Carcinoma Cells) 80 0.35 Functional ≤ 10μM
Z80224 Z80224 MCF7 (Breast Carcinoma Cells) 26 0.38 Functional ≤ 10μM
Z100095 Z100095 MIP (Colon Carcinoma Cells) 120 0.35 Functional ≤ 10μM
Z100094 Z100094 MLF (Lung Fibroblast Cells) 72 0.36 Functional ≤ 10μM
Z80354 Z80354 OVCAR-3 (Ovarian Adenocarcinoma Cells) 54 0.36 Functional ≤ 10μM
Z80390 Z80390 PC-3 (Prostate Carcinoma Cells) 10000 0.25 Functional ≤ 10μM
Z80475 Z80475 SK-BR-3 (Breast Adenocarcinoma) 77 0.36 Functional ≤ 10μM

Reactome Annotations from Targets (via Uniprot)

Description Species
Acetylcholine regulates insulin secretion
Activation of ATR in response to replication stress
Activation of CaMK IV
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
Activation of NF-kappaB in B cells
Activation of NIMA Kinases NEK9, NEK6, NEK7
Activation of the AP-1 family of transcription factors
Activation of the pre-replicative complex
AKT phosphorylates targets in the cytosol
Antigen activates B Cell Receptor (BCR) leading to generation of second messenge
APC truncation mutants have impaired AXIN binding
APC/C:Cdc20 mediated degradation of Cyclin B
Apoptotic cleavage of cellular proteins
AXIN missense mutants destabilize the destruction complex
Beta-catenin phosphorylation cascade
Ca2+ pathway
Calmodulin induced events
CaMK IV-mediated phosphorylation of CREB
CDK-mediated phosphorylation and removal of Cdc6
Cell surface interactions at the vascular wall
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
Condensation of Prometaphase Chromosomes
Condensation of Prophase Chromosomes
Constitutive PI3K/AKT Signaling in Cancer
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Constitutive Signaling by NOTCH1 PEST Domain Mutants
CREB phosphorylation
CREB phosphorylation through the activation of CaMKII
CREB phosphorylation through the activation of CaMKK
CREB phosphorylation through the activation of Ras
CRMPs in Sema3A signaling
Cyclin A/B1 associated events during G2/M transition
Cyclin A:Cdk2-associated events at S phase entry
Cyclin B2 mediated events
Cyclin D associated events in G1
Cyclin E associated events during G1/S transition
DAG and IP3 signaling
DARPP-32 events
Degradation of beta-catenin by the destruction complex
Depolymerisation of the Nuclear Lamina
disassembly of the destruction complex and recruitment of AXIN to the membrane
Disinhibition of SNARE formation
DNA Damage/Telomere Stress Induced Senescence
Downregulation of TGF-beta receptor signaling
Downstream TCR signaling
Dual incision reaction in GG-NER
Dual incision reaction in TC-NER
E2F mediated regulation of DNA replication
E2F-enabled inhibition of pre-replication complex formation
Effects of PIP2 hydrolysis
EGFR downregulation
EGFR interacts with phospholipase C-gamma
EGFR Transactivation by Gastrin
EPH-ephrin mediated repulsion of cells
EPH-Ephrin signaling
EPHA-mediated growth cone collapse
EPHB-mediated forward signaling
Ephrin signaling
ERK/MAPK targets
ERK1 activation
ERKs are inactivated
Factors involved in megakaryocyte development and platelet production
FCERI mediated MAPK activation
FCERI mediated NF-kB activation
Formation of HIV elongation complex in the absence of HIV Tat
Formation of HIV-1 elongation complex containing HIV-1 Tat
Formation of incision complex in GG-NER
Formation of RNA Pol II elongation complex
Formation of the Early Elongation Complex
Formation of the HIV-1 Early Elongation Complex
Formation of transcription-coupled NER (TC-NER) repair complex
G alpha (z) signalling events
G0 and Early G1
G1/S-Specific Transcription
G2 Phase
G2/M DNA replication checkpoint
GAB1 signalosome
Gastrin-CREB signalling pathway via PKC and MAPK
Generic Transcription Pathway
Glycogen breakdown (glycogenolysis)
Golgi Associated Vesicle Biogenesis
Golgi Cisternae Pericentriolar Stack Reorganization
GPVI-mediated activation cascade
GRB2 events in EGFR signaling
GRB2 events in ERBB2 signaling
HIV elongation arrest and recovery
HIV Transcription Initiation
HSF1-dependent transactivation
HuR stabilizes mRNA
Inactivation, recovery and regulation of the phototransduction cascade
Inhibition of PKR
Interactions of Tat with host cellular proteins
Interferon gamma signaling
ISG15 antiviral mechanism
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human
Loss of Nlp from mitotic centrosomes
Loss of proteins required for interphase microtubule organization from the ce
MASTL Facilitates Mitotic Progression
Meiotic recombination
misspliced GSK3beta mutants stabilize beta-catenin
mRNA Capping
NCAM signaling for neurite out-growth
Negative regulators of RIG-I/MDA5 signaling
Netrin-1 signaling
NoRC negatively regulates rRNA expression
NOTCH1 Intracellular Domain Regulates Transcription
Nuclear Pore Complex (NPC) Disassembly
Oncogene Induced Senescence
Orc1 removal from chromatin
Oxidative Stress Induced Senescence
p53-Dependent G1 DNA Damage Response
p75NTR recruits signalling complexes
Pausing and recovery of HIV elongation
Pausing and recovery of Tat-mediated HIV elongation
Phosphorylation of Emi1
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2
Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 com
Phosphorylation of the APC/C
PI3K events in ERBB2 signaling
PIP3 activates AKT signaling
PLCG1 events in ERBB2 signaling
Polo-like kinase mediated events
PPARA activates gene expression
Pre-NOTCH Transcription and Translation
Ras activation uopn Ca2+ infux through NMDA receptor
Recruitment of mitotic centrosome proteins and complexes
Recruitment of NuMA to mitotic centrosomes
Recycling pathway of L1
Regulation of AMPK activity via LKB1
Regulation of APC/C activators between G1/S and early anaphase
Regulation of HSF1-mediated heat shock response
Regulation of KIT signaling
Regulation of PLK1 Activity at G2/M Transition
Regulation of Rheb GTPase activity by AMPK
Regulation of signaling by NODAL
Resolution of Sister Chromatid Cohesion
Response to elevated platelet cytosolic Ca2+
RMTs methylate histone arginines
RNA Pol II CTD phosphorylation and interaction with CE
RNA Polymerase I Chain Elongation
RNA Polymerase I Promoter Escape
RNA Polymerase I Transcription Initiation
RNA Polymerase I Transcription Termination
RNA Polymerase II HIV Promoter Escape
RNA Polymerase II Pre-transcription Events
RNA Polymerase II Promoter Escape
RNA Polymerase II Transcription Elongation
RNA Polymerase II Transcription Initiation
RNA Polymerase II Transcription Initiation And Promoter Clearance
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
Role of phospholipids in phagocytosis
RSK activation
S33 mutants of beta-catenin aren't phosphorylated
S37 mutants of beta-catenin aren't phosphorylated
S45 mutants of beta-catenin aren't phosphorylated
SCF(Skp2)-mediated degradation of p27/p21
Senescence-Associated Secretory Phenotype (SASP)
SHC1 events in EGFR signaling
SHC1 events in ERBB2 signaling
Signal transduction by L1
Signaling by Activin
Signaling by BMP
Signaling by constitutively active EGFR
Signaling by EGFR
Signaling by ERBB2
Signaling by ERBB4
Signaling by Hippo
Signaling by NODAL
Signaling by SCF-KIT
Signalling to ERK5
SMAD2/3 MH2 Domain Mutants in Cancer
SMAD2/3 Phosphorylation Motif Mutants in Cancer
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Sphingolipid de novo biosynthesis
Syndecan interactions
T41 mutants of beta-catenin aren't phosphorylated
Tat-mediated elongation of the HIV-1 transcript
Tat-mediated HIV elongation arrest and recovery
TGF-beta receptor signaling activates SMADs
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
TGFBR1 KD Mutants in Cancer
TGFBR1 LBD Mutants in Cancer
TGFBR2 Kinase Domain Mutants in Cancer
TGFBR2 MSI Frameshift Mutants in Cancer
Tight junction interactions
TRAF3-dependent IRF activation pathway
TRAF6 mediated IRF7 activation
Trafficking of AMPA receptors
Trafficking of GluR2-containing AMPA receptors
Transcription of the HIV genome
Transcriptional activation of mitochondrial biogenesis
Transcriptional regulation of white adipocyte differentiation
truncations of AMER1 destabilize the destruction complex
Ubiquitin-dependent degradation of Cyclin D1
Unblocking of NMDA receptor, glutamate binding and activation
VEGFA-VEGFR2 Pathway
VEGFR2 mediated cell proliferation
WNT5A-dependent internalization of FZD4
XBP1(S) activates chaperone genes

Analogs ( Draw Identity 99% 90% 80% 70% )