Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	2.39	10.08	-45.78	2	9	1	94	424.529	6	↓ MOL2 SDF SMILES Flexibase
Hi High (pH 8-9.5)	2.39	7.8	-18.86	1	9	0	92	423.521	6	↓ MOL2 SDF SMILES Flexibase
Hi High (pH 8-9.5)	2.21	8.98	-37.95	1	9	0	100	423.521	6	↓ MOL2 SDF SMILES Flexibase

Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
AA1R-2-E	Adenosine A1 Receptor (cluster #2 Of 4), Eukaryotic	Eukaryotes	1880	0.26	Binding ≤ 10μM
AA2AR-1-E	Adenosine A2a Receptor (cluster #1 Of 4), Eukaryotic	Eukaryotes	270	0.30	Binding ≤ 10μM

ChEMBL Target Annotations
Uniprot	Swissprot	Description	Affinity (nM)	LE (kcal/mol/atom)	Type
AA2AR_RAT	P30543	Adenosine A2a Receptor, Rat	270	0.30	Binding ≤ 1μM
AA2AR_HUMAN	P29274	Adenosine A2a Receptor, Human	11	0.36	Binding ≤ 1μM
AA1R_HUMAN	P30542	Adenosine A1 Receptor, Human	1880	0.26	Binding ≤ 10μM
AA2AR_RAT	P30543	Adenosine A2a Receptor, Rat	270	0.30	Binding ≤ 10μM
AA2AR_HUMAN	P29274	Adenosine A2a Receptor, Human	11	0.36	Binding ≤ 10μM

Description	Species
Adenosine P1 receptors	Rattus norvegicus (AA2AR_RAT) Homo sapiens (AA2AR_HUMAN)
G alpha (i) signalling events	Homo sapiens (AA1R_HUMAN)
G alpha (s) signalling events	Rattus norvegicus (AA2AR_RAT) Homo sapiens (AA2AR_HUMAN)
NGF-independant TRKA activation	Rattus norvegicus (AA2AR_RAT) Homo sapiens (AA2AR_HUMAN)