In ZINC since | Heavy atoms | Benign functionality |
---|---|---|
February 4th, 2009 | 40 | No |
Popular Name: LS-193210 LS-193210
Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
---|---|---|---|---|---|---|---|---|---|---|
Ref Reference (pH 7) | 5.77 | 12.44 | -62.71 | 2 | 8 | -1 | 111 | 562.609 | 11 | ↓ |
Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
---|---|---|---|---|---|
ADCY1-1-E | Brain Adenylate Cyclase 1 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 254 | 0.23 | Binding ≤ 10μM |
ADCY2-2-E | Adenylate Cyclase Type II (cluster #2 Of 2), Eukaryotic | Eukaryotes | 254 | 0.23 | Binding ≤ 10μM |
ADCY3-2-E | Adenylate Cyclase Type III (cluster #2 Of 2), Eukaryotic | Eukaryotes | 254 | 0.23 | Binding ≤ 10μM |
ADCY4-2-E | Adenylate Cyclase Type IV (cluster #2 Of 2), Eukaryotic | Eukaryotes | 254 | 0.23 | Binding ≤ 10μM |
ADCY5-2-E | Adenylate Cyclase Type V (cluster #2 Of 2), Eukaryotic | Eukaryotes | 254 | 0.23 | Binding ≤ 10μM |
ADCY6-2-E | Adenylate Cyclase Type VI (cluster #2 Of 2), Eukaryotic | Eukaryotes | 254 | 0.23 | Binding ≤ 10μM |
ADCY7-2-E | Adenylate Cyclase Type VII (cluster #2 Of 2), Eukaryotic | Eukaryotes | 254 | 0.23 | Binding ≤ 10μM |
ADCY8-1-E | Adenylate Cyclase Type VIII (cluster #1 Of 2), Eukaryotic | Eukaryotes | 254 | 0.23 | Binding ≤ 10μM |
ADCY9-2-E | Adenylate Cyclase Type IX (cluster #2 Of 2), Eukaryotic | Eukaryotes | 254 | 0.23 | Binding ≤ 10μM |
GIPR-1-E | Gastric Inhibitory Polypeptide Receptor (cluster #1 Of 1), Eukaryotic | Eukaryotes | 28 | 0.26 | Binding ≤ 10μM |
GLP1R-1-E | Glucagon-like Peptide Receptor (cluster #1 Of 1), Eukaryotic | Eukaryotes | 1000 | 0.21 | Binding ≤ 10μM |
GLP1R-1-E | Glucagon-like Peptide Receptor (cluster #1 Of 1), Eukaryotic | Eukaryotes | 2536 | 0.20 | Binding ≤ 10μM |
GLR-1-E | Glucagon Receptor (cluster #1 Of 2), Eukaryotic | Eukaryotes | 23 | 0.27 | Binding ≤ 10μM |
GLR-1-E | Glucagon Receptor (cluster #1 Of 2), Eukaryotic | Eukaryotes | 47 | 0.26 | Binding ≤ 10μM |
GLR-1-E | Glucagon Receptor (cluster #1 Of 2), Eukaryotic | Eukaryotes | 63 | 0.25 | Binding ≤ 10μM |
GIPR-1-E | Gastric Inhibitory Polypeptide Receptor (cluster #1 Of 1), Eukaryotic | Eukaryotes | 1300 | 0.21 | Functional ≤ 10μM |
GLR-1-E | Glucagon Receptor (cluster #1 Of 1), Eukaryotic | Eukaryotes | 21 | 0.27 | Functional ≤ 10μM |
GLR-1-E | Glucagon Receptor (cluster #1 Of 1), Eukaryotic | Eukaryotes | 140 | 0.24 | Functional ≤ 10μM |
Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
---|---|---|---|---|---|
ADCY2_HUMAN | Q08462 | Adenylate Cyclase Type II, Human | 254 | 0.23 | Binding ≤ 1μM |
ADCY3_HUMAN | O60266 | Adenylate Cyclase Type III, Human | 254 | 0.23 | Binding ≤ 1μM |
ADCY4_HUMAN | Q8NFM4 | Adenylate Cyclase Type IV, Human | 254 | 0.23 | Binding ≤ 1μM |
ADCY9_HUMAN | O60503 | Adenylate Cyclase Type IX, Human | 254 | 0.23 | Binding ≤ 1μM |
ADCY5_HUMAN | O95622 | Adenylate Cyclase Type V, Human | 254 | 0.23 | Binding ≤ 1μM |
ADCY6_HUMAN | O43306 | Adenylate Cyclase Type VI, Human | 254 | 0.23 | Binding ≤ 1μM |
ADCY7_HUMAN | P51828 | Adenylate Cyclase Type VII, Human | 254 | 0.23 | Binding ≤ 1μM |
ADCY8_HUMAN | P40145 | Adenylate Cyclase Type VIII, Human | 254 | 0.23 | Binding ≤ 1μM |
ADCY1_HUMAN | Q08828 | Brain Adenylate Cyclase 1, Human | 254 | 0.23 | Binding ≤ 1μM |
GIPR_HUMAN | P48546 | Gastric Inhibitory Polypeptide Receptor, Human | 28.3 | 0.26 | Binding ≤ 1μM |
GIPR_RAT | P43219 | Gastric Inhibitory Polypeptide Receptor, Rat | 42 | 0.26 | Binding ≤ 1μM |
GLR_RAT | P30082 | Glucagon Receptor, Rat | 23 | 0.27 | Binding ≤ 1μM |
GLR_HUMAN | P47871 | Glucagon Receptor, Human | 23.4 | 0.27 | Binding ≤ 1μM |
GLP1R_HUMAN | P43220 | Glucagon-like Peptide Receptor, Human | 1000 | 0.21 | Binding ≤ 1μM |
ADCY2_HUMAN | Q08462 | Adenylate Cyclase Type II, Human | 254 | 0.23 | Binding ≤ 10μM |
ADCY3_HUMAN | O60266 | Adenylate Cyclase Type III, Human | 254 | 0.23 | Binding ≤ 10μM |
ADCY4_HUMAN | Q8NFM4 | Adenylate Cyclase Type IV, Human | 254 | 0.23 | Binding ≤ 10μM |
ADCY9_HUMAN | O60503 | Adenylate Cyclase Type IX, Human | 254 | 0.23 | Binding ≤ 10μM |
ADCY5_HUMAN | O95622 | Adenylate Cyclase Type V, Human | 254 | 0.23 | Binding ≤ 10μM |
ADCY6_HUMAN | O43306 | Adenylate Cyclase Type VI, Human | 254 | 0.23 | Binding ≤ 10μM |
ADCY7_HUMAN | P51828 | Adenylate Cyclase Type VII, Human | 254 | 0.23 | Binding ≤ 10μM |
ADCY8_HUMAN | P40145 | Adenylate Cyclase Type VIII, Human | 254 | 0.23 | Binding ≤ 10μM |
ADCY1_HUMAN | Q08828 | Brain Adenylate Cyclase 1, Human | 254 | 0.23 | Binding ≤ 10μM |
GIPR_RAT | P43219 | Gastric Inhibitory Polypeptide Receptor, Rat | 42 | 0.26 | Binding ≤ 10μM |
GIPR_HUMAN | P48546 | Gastric Inhibitory Polypeptide Receptor, Human | 28.3 | 0.26 | Binding ≤ 10μM |
GLR_HUMAN | P47871 | Glucagon Receptor, Human | 23.4 | 0.27 | Binding ≤ 10μM |
GLR_RAT | P30082 | Glucagon Receptor, Rat | 23 | 0.27 | Binding ≤ 10μM |
GLP1R_HUMAN | P43220 | Glucagon-like Peptide Receptor, Human | 2536 | 0.20 | Binding ≤ 10μM |
GIPR_HUMAN | P48546 | Gastric Inhibitory Polypeptide Receptor, Human | 1300 | 0.21 | Functional ≤ 10μM |
GLR_HUMAN | P47871 | Glucagon Receptor, Human | 144 | 0.24 | Functional ≤ 10μM |
Description | Species |
---|---|
Adenylate cyclase activating pathway | |
Adenylate cyclase inhibitory pathway | |
Adrenaline,noradrenaline inhibits insulin secretion | |
CREB phosphorylation through the activation of Adenylate Cyclase | |
G alpha (i) signalling events | |
G alpha (q) signalling events | |
G alpha (s) signalling events | |
G alpha (z) signalling events | |
Glucagon signaling in metabolic regulation | |
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | |
Glucagon-type ligand receptors | |
PKA activation | |
PKA activation in glucagon signalling | |
Vasopressin regulates renal water homeostasis via Aquaporins |