In ZINC since | Heavy atoms | Benign functionality |
---|---|---|
September 29th, 2005 | 25 | No |
Popular Name: ARP 100 ARP 100
Find On: PubMed — Wikipedia — Google
CAS Numbers: 704888-90-4 , [704888-90-4]
Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
---|---|---|---|---|---|---|---|---|---|---|
Ref Reference (pH 7) | 2.53 | 4.59 | -15.92 | 2 | 7 | 0 | 96 | 364.423 | 7 | ↓ |
Hi High (pH 8-9.5) | 2.53 | 5.81 | -53.13 | 1 | 7 | -1 | 99 | 363.415 | 7 | ↓ |
Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
---|---|---|---|---|---|
MMP1-1-E | Matrix Metalloproteinase-1 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 2900 | 0.31 | Binding ≤ 10μM |
MMP13-3-E | Matrix Metalloproteinase 13 (cluster #3 Of 4), Eukaryotic | Eukaryotes | 45 | 0.41 | Binding ≤ 10μM |
MMP14-2-E | Matrix Metalloproteinase 14 (cluster #2 Of 3), Eukaryotic | Eukaryotes | 2300 | 0.32 | Binding ≤ 10μM |
MMP16-1-E | Matrix Metalloproteinase 16 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 900 | 0.34 | Binding ≤ 10μM |
MMP2-1-E | 72 KDa Type IV Collagenase (cluster #1 Of 3), Eukaryotic | Eukaryotes | 13 | 0.44 | Binding ≤ 10μM |
MMP3-1-E | Matrix Metalloproteinase 3 (cluster #1 Of 3), Eukaryotic | Eukaryotes | 5900 | 0.29 | Binding ≤ 10μM |
MMP8-3-E | Matrix Metalloproteinase 8 (cluster #3 Of 4), Eukaryotic | Eukaryotes | 260 | 0.37 | Binding ≤ 10μM |
MMP9-1-E | Matrix Metalloproteinase 9 (cluster #1 Of 3), Eukaryotic | Eukaryotes | 200 | 0.38 | Binding ≤ 10μM |
Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
---|---|---|---|---|---|
MMP13_HUMAN | P45452 | Matrix Metalloproteinase 13, Human | 20 | 0.43 | Binding ≤ 1μM |
MMP16_HUMAN | P51512 | Matrix Metalloproteinase 16, Human | 900 | 0.34 | Binding ≤ 1μM |
MMP8_HUMAN | P22894 | Matrix Metalloproteinase 8, Human | 260 | 0.37 | Binding ≤ 1μM |
MMP9_HUMAN | P14780 | Matrix Metalloproteinase 9, Human | 200 | 0.38 | Binding ≤ 1μM |
MMP2_HUMAN | P08253 | Matrix Metalloproteinase-2, Human | 12 | 0.44 | Binding ≤ 1μM |
MMP13_HUMAN | P45452 | Matrix Metalloproteinase 13, Human | 20 | 0.43 | Binding ≤ 10μM |
MMP14_HUMAN | P50281 | Matrix Metalloproteinase 14, Human | 2300 | 0.32 | Binding ≤ 10μM |
MMP16_HUMAN | P51512 | Matrix Metalloproteinase 16, Human | 900 | 0.34 | Binding ≤ 10μM |
MMP3_HUMAN | P08254 | Matrix Metalloproteinase 3, Human | 4500 | 0.30 | Binding ≤ 10μM |
MMP8_HUMAN | P22894 | Matrix Metalloproteinase 8, Human | 260 | 0.37 | Binding ≤ 10μM |
MMP9_HUMAN | P14780 | Matrix Metalloproteinase 9, Human | 200 | 0.38 | Binding ≤ 10μM |
MMP1_HUMAN | P03956 | Matrix Metalloproteinase-1, Human | 2900 | 0.31 | Binding ≤ 10μM |
MMP2_HUMAN | P08253 | Matrix Metalloproteinase-2, Human | 12 | 0.44 | Binding ≤ 10μM |
Description | Species |
---|---|
Activation of Matrix Metalloproteinases | |
Assembly of collagen fibrils and other multimeric structures | |
Basigin interactions | |
Collagen degradation | |
Degradation of the extracellular matrix | |
EGFR Transactivation by Gastrin | |
EPH-ephrin mediated repulsion of cells | |
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l | |
Signaling by SCF-KIT |
No pre-computed analogs available. Try a structural similarity search.