UCSF

ZINC03938688

Draw Identity 99% 90% 80% 70%

Substance Information

In ZINC since Heavy atoms Benign functionality
October 21st, 2005 27 Yes

Popular Name: JNJ-7706621 JNJ-7706621

Find On: PubMed — Wikipedia — Google

CAS Numbers: 443797-96-4 , [443797-96-4]

Download: MOL2 SDF SMILES Flexibase

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.97 5.91 -18.67 5 9 0 146 394.363 4 ↓

Vendor Notes

Note Type Comments Provided By
Target CDK, Aurora Kinase Selleck Chemicals

Activity (Go SEA)

Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
AAK1-1-E Adaptor-associated Kinase (cluster #1 Of 2), Eukaryotic Eukaryotes 200 0.35 Binding ≤ 10μM
AAPK1-1-E AMP-activated Protein Kinase, Alpha-1 Subunit (cluster #1 Of 1), Eukaryotic Eukaryotes 1700 0.30 Binding ≤ 10μM
AAPK2-1-E AMP-activated Protein Kinase, Alpha-2 Subunit (cluster #1 Of 1), Eukaryotic Eukaryotes 1800 0.30 Binding ≤ 10μM
ABL1-1-E Tyrosine-protein Kinase ABL (cluster #1 Of 1), Eukaryotic Eukaryotes 820 0.32 Binding ≤ 10μM
ACVL1-1-E Serine/threonine-protein Kinase Receptor R3 (cluster #1 Of 1), Eukaryotic Eukaryotes 2900 0.29 Binding ≤ 10μM
ACVR1-1-E Activin Receptor Type-1 (cluster #1 Of 1), Eukaryotic Eukaryotes 5900 0.27 Binding ≤ 10μM
ADCK3-1-E Chaperone Activity Of Bc1 Complex-like, Mitochondrial (cluster #1 Of 1), Eukaryotic Eukaryotes 1200 0.31 Binding ≤ 10μM
ALK-1-E ALK Tyrosine Kinase Receptor (cluster #1 Of 1), Eukaryotic Eukaryotes 7100 0.27 Binding ≤ 10μM
ANKK1-1-E Ankyrin Repeat And Protein Kinase Domain-containing Protein 1 (cluster #1 Of 1), Eukaryotic Eukaryotes 500 0.33 Binding ≤ 10μM
AURKA-3-E Serine/threonine-protein Kinase Aurora-A (cluster #3 Of 3), Eukaryotic Eukaryotes 250 0.34 Binding ≤ 10μM
AURKB-1-E Serine/threonine-protein Kinase Aurora-B (cluster #1 Of 2), Eukaryotic Eukaryotes 160 0.35 Binding ≤ 10μM
AURKC-1-E Serine/threonine-protein Kinase Aurora-C (cluster #1 Of 2), Eukaryotic Eukaryotes 86 0.37 Binding ≤ 10μM
AVR2A-1-E Activin Receptor Type-2A (cluster #1 Of 1), Eukaryotic Eukaryotes 2900 0.29 Binding ≤ 10μM
AVR2B-1-E Activin Receptor Type-2B (cluster #1 Of 1), Eukaryotic Eukaryotes 5900 0.27 Binding ≤ 10μM
BMP2K-1-E BMP-2-inducible Protein Kinase (cluster #1 Of 2), Eukaryotic Eukaryotes 180 0.35 Binding ≤ 10μM
BMPR2-1-E Bone Morphogenetic Protein Receptor Type-2 (cluster #1 Of 1), Eukaryotic Eukaryotes 880 0.31 Binding ≤ 10μM
BMX-1-E Tyrosine-protein Kinase BMX (cluster #1 Of 1), Eukaryotic Eukaryotes 4700 0.28 Binding ≤ 10μM
BRSK1-1-E BR Serine/threonine-protein Kinase 1 (cluster #1 Of 1), Eukaryotic Eukaryotes 6500 0.27 Binding ≤ 10μM
BRSK2-1-E BR Serine/threonine-protein Kinase 2 (cluster #1 Of 1), Eukaryotic Eukaryotes 2700 0.29 Binding ≤ 10μM
CCNA1-1-E Cyclin A1 (cluster #1 Of 3), Eukaryotic Eukaryotes 2 0.45 Binding ≤ 10μM
CCNA2-1-E Cyclin A2 (cluster #1 Of 3), Eukaryotic Eukaryotes 2 0.45 Binding ≤ 10μM
CCNB1-1-E G2/mitotic-specific Cyclin B1 (cluster #1 Of 2), Eukaryotic Eukaryotes 6 0.43 Binding ≤ 10μM
CCNB2-1-E G2/mitotic-specific Cyclin B2 (cluster #1 Of 2), Eukaryotic Eukaryotes 6 0.43 Binding ≤ 10μM
CCNB3-1-E G2/mitotic-specific Cyclin B3 (cluster #1 Of 2), Eukaryotic Eukaryotes 6 0.43 Binding ≤ 10μM
CD11A-1-E PITSLRE Serine/threonine-protein Kinase CDC2L2 (cluster #1 Of 1), Eukaryotic Eukaryotes 110 0.36 Binding ≤ 10μM
CD11B-1-E PITSLRE Serine/threonine-protein Kinase CDC2L1 (cluster #1 Of 1), Eukaryotic Eukaryotes 150 0.35 Binding ≤ 10μM
CDK1-1-E Cyclin-dependent Kinase 1 (cluster #1 Of 4), Eukaryotic Eukaryotes 6 0.43 Binding ≤ 10μM
CDK14-1-E Serine/threonine-protein Kinase PFTAIRE-1 (cluster #1 Of 1), Eukaryotic Eukaryotes 3600 0.28 Binding ≤ 10μM
CDK16-1-E Serine/threonine-protein Kinase PCTAIRE-1 (cluster #1 Of 1), Eukaryotic Eukaryotes 23 0.40 Binding ≤ 10μM
CDK17-1-E Serine/threonine-protein Kinase PCTAIRE-2 (cluster #1 Of 1), Eukaryotic Eukaryotes 290 0.34 Binding ≤ 10μM
CDK18-1-E Serine/threonine-protein Kinase PCTAIRE-3 (cluster #1 Of 1), Eukaryotic Eukaryotes 2100 0.29 Binding ≤ 10μM
CDK2-1-E Cyclin-dependent Kinase 2 (cluster #1 Of 5), Eukaryotic Eukaryotes 23 0.40 Binding ≤ 10μM
CDK3-1-E Cyclin-dependent Kinase 3 (cluster #1 Of 1), Eukaryotic Eukaryotes 180 0.35 Binding ≤ 10μM
CDK5-1-E Cyclin-dependent Kinase 5 (cluster #1 Of 1), Eukaryotic Eukaryotes 240 0.34 Binding ≤ 10μM
CDK7-1-E Cyclin-dependent Kinase 7 (cluster #1 Of 1), Eukaryotic Eukaryotes 760 0.32 Binding ≤ 10μM
CDK9-1-E Cyclin-dependent Kinase 9 (cluster #1 Of 2), Eukaryotic Eukaryotes 470 0.33 Binding ≤ 10μM
CLK1-1-E Dual Specificty Protein Kinase CLK1 (cluster #1 Of 2), Eukaryotic Eukaryotes 660 0.32 Binding ≤ 10μM
CLK2-1-E Dual Specificity Protein Kinase CLK2 (cluster #1 Of 2), Eukaryotic Eukaryotes 290 0.34 Binding ≤ 10μM
CLK3-1-E Dual Specificity Protein Kinase CLK3 (cluster #1 Of 1), Eukaryotic Eukaryotes 310 0.34 Binding ≤ 10μM
CLK4-1-E Dual Specificity Protein Kinase CLK4 (cluster #1 Of 2), Eukaryotic Eukaryotes 1700 0.30 Binding ≤ 10μM
CSF1R-1-E Macrophage Colony-stimulating Factor 1 Receptor (cluster #1 Of 1), Eukaryotic Eukaryotes 4200 0.28 Binding ≤ 10μM
CSK22-1-E Casein Kinase II Alpha (prime) (cluster #1 Of 2), Eukaryotic Eukaryotes 2000 0.30 Binding ≤ 10μM
DAPK3-1-E Death-associated Protein Kinase 3 (cluster #1 Of 2), Eukaryotic Eukaryotes 5200 0.27 Binding ≤ 10μM
DCLK1-1-E Serine/threonine-protein Kinase DCLK1 (cluster #1 Of 1), Eukaryotic Eukaryotes 2500 0.29 Binding ≤ 10μM
DCLK2-1-E Serine/threonine-protein Kinase DCLK2 (cluster #1 Of 1), Eukaryotic Eukaryotes 4500 0.28 Binding ≤ 10μM
DCLK3-1-E Serine/threonine-protein Kinase DCLK3 (cluster #1 Of 1), Eukaryotic Eukaryotes 6500 0.27 Binding ≤ 10μM
DMPK-1-E Myotonin-protein Kinase (cluster #1 Of 1), Eukaryotic Eukaryotes 1200 0.31 Binding ≤ 10μM
E2AK2-1-E Interferon-induced, Double-stranded RNA-activated Protein Kinase (cluster #1 Of 1), Eukaryotic Eukaryotes 6300 0.27 Binding ≤ 10μM
E2AK4-1-E Eukaryotic Translation Initiation Factor 2-alpha Kinase 4 (cluster #1 Of 1), Eukaryotic Eukaryotes 3900 0.28 Binding ≤ 10μM
EPHA7-1-E Ephrin Type-A Receptor 7 (cluster #1 Of 1), Eukaryotic Eukaryotes 3100 0.29 Binding ≤ 10μM
FGFR1-1-E Fibroblast Growth Factor Receptor 1 (cluster #1 Of 1), Eukaryotic Eukaryotes 810 0.32 Binding ≤ 10μM
FGFR2-1-E Fibroblast Growth Factor Receptor 2 (cluster #1 Of 1), Eukaryotic Eukaryotes 680 0.32 Binding ≤ 10μM
FGFR3-1-E Fibroblast Growth Factor Receptor 3 (cluster #1 Of 1), Eukaryotic Eukaryotes 690 0.32 Binding ≤ 10μM
FGR-1-E Tyrosine-protein Kinase FGR (cluster #1 Of 2), Eukaryotic Eukaryotes 2000 0.30 Binding ≤ 10μM
FLT3-1-E Tyrosine-protein Kinase Receptor FLT3 (cluster #1 Of 1), Eukaryotic Eukaryotes 850 0.31 Binding ≤ 10μM
GAK-1-E Serine/threonine-protein Kinase GAK (cluster #1 Of 2), Eukaryotic Eukaryotes 2400 0.29 Binding ≤ 10μM
GSK3A-1-E Glycogen Synthase Kinase-3 Alpha (cluster #1 Of 3), Eukaryotic Eukaryotes 41 0.38 Binding ≤ 10μM
GSK3B-1-E Glycogen Synthase Kinase-3 Beta (cluster #1 Of 7), Eukaryotic Eukaryotes 950 0.31 Binding ≤ 10μM
IKKE-1-E Inhibitor Of Nuclear Factor Kappa B Kinase Epsilon Subunit (cluster #1 Of 1), Eukaryotic Eukaryotes 8300 0.26 Binding ≤ 10μM
IRAK3-1-E Interleukin-1 Receptor-associated Kinase 3 (cluster #1 Of 1), Eukaryotic Eukaryotes 3400 0.28 Binding ≤ 10μM
JAK1-1-E Tyrosine-protein Kinase JAK1 (cluster #1 Of 1), Eukaryotic Eukaryotes 21 0.40 Binding ≤ 10μM
JAK2-1-E Tyrosine-protein Kinase JAK2 (cluster #1 Of 1), Eukaryotic Eukaryotes 220 0.35 Binding ≤ 10μM
JAK3-1-E Tyrosine-protein Kinase JAK3 (cluster #1 Of 2), Eukaryotic Eukaryotes 180 0.35 Binding ≤ 10μM
KC1E-1-E Casein Kinase I Epsilon (cluster #1 Of 2), Eukaryotic Eukaryotes 3600 0.28 Binding ≤ 10μM
KC1G1-1-E Casein Kinase I Gamma 1 (cluster #1 Of 2), Eukaryotic Eukaryotes 1200 0.31 Binding ≤ 10μM
KC1G2-1-E Casein Kinase I Gamma 2 (cluster #1 Of 1), Eukaryotic Eukaryotes 740 0.32 Binding ≤ 10μM
KC1G3-1-E Casein Kinase I Isoform Gamma-3 (cluster #1 Of 1), Eukaryotic Eukaryotes 7900 0.26 Binding ≤ 10μM
KIT-1-E Stem Cell Growth Factor Receptor (cluster #1 Of 1), Eukaryotic Eukaryotes 590 0.32 Binding ≤ 10μM
KKCC1-1-E CaM-kinase Kinase Alpha (cluster #1 Of 1), Eukaryotic Eukaryotes 2900 0.29 Binding ≤ 10μM
KKCC2-1-E CaM-kinase Kinase Beta (cluster #1 Of 2), Eukaryotic Eukaryotes 2600 0.29 Binding ≤ 10μM
KPCD-1-E Protein Kinase C Delta (cluster #1 Of 4), Eukaryotic Eukaryotes 4500 0.28 Binding ≤ 10μM
KPCD1-1-E Protein Kinase C Mu (cluster #1 Of 3), Eukaryotic Eukaryotes 8400 0.26 Binding ≤ 10μM
KPCD3-1-E Protein Kinase C Nu (cluster #1 Of 3), Eukaryotic Eukaryotes 4200 0.28 Binding ≤ 10μM
KPCT-1-E Protein Kinase C Theta (cluster #1 Of 3), Eukaryotic Eukaryotes 4400 0.28 Binding ≤ 10μM
KS6A1-1-E Ribosomal Protein S6 Kinase Alpha 1 (cluster #1 Of 1), Eukaryotic Eukaryotes 4000 0.28 Binding ≤ 10μM
KS6A2-1-E Ribosomal Protein S6 Kinase Alpha 2 (cluster #1 Of 2), Eukaryotic Eukaryotes 410 0.33 Binding ≤ 10μM
KS6A4-1-E Ribosomal Protein S6 Kinase Alpha 4 (cluster #1 Of 1), Eukaryotic Eukaryotes 3000 0.29 Binding ≤ 10μM
KSYK-1-E Tyrosine-protein Kinase SYK (cluster #1 Of 2), Eukaryotic Eukaryotes 1300 0.31 Binding ≤ 10μM
LIMK1-1-E LIM Domain Kinase 1 (cluster #1 Of 1), Eukaryotic Eukaryotes 620 0.32 Binding ≤ 10μM
LIMK2-1-E LIM Domain Kinase 2 (cluster #1 Of 1), Eukaryotic Eukaryotes 1000 0.31 Binding ≤ 10μM
M3K9-1-E Mitogen-activated Protein Kinase Kinase Kinase 9 (cluster #1 Of 1), Eukaryotic Eukaryotes 3600 0.28 Binding ≤ 10μM
M4K1-1-E Mitogen-activated Protein Kinase Kinase Kinase Kinase 1 (cluster #1 Of 1), Eukaryotic Eukaryotes 120 0.36 Binding ≤ 10μM
M4K3-1-E Mitogen-activated Protein Kinase Kinase Kinase Kinase 3 (cluster #1 Of 1), Eukaryotic Eukaryotes 820 0.32 Binding ≤ 10μM
M4K5-1-E Mitogen-activated Protein Kinase Kinase Kinase Kinase 5 (cluster #1 Of 1), Eukaryotic Eukaryotes 2100 0.29 Binding ≤ 10μM
MARK1-1-E Serine/threonine-protein Kinase MARK1 (cluster #1 Of 1), Eukaryotic Eukaryotes 620 0.32 Binding ≤ 10μM
MARK2-1-E MAP/microtubule Affinity-regulating Kinase 2 (cluster #1 Of 2), Eukaryotic Eukaryotes 1200 0.31 Binding ≤ 10μM
MARK3-1-E Serine/threonine-protein Kinase C-TAK1 (cluster #1 Of 1), Eukaryotic Eukaryotes 600 0.32 Binding ≤ 10μM
MARK4-1-E MAP/microtubule Affinity-regulating Kinase 4 (cluster #1 Of 1), Eukaryotic Eukaryotes 660 0.32 Binding ≤ 10μM
MERTK-1-E Proto-oncogene Tyrosine-protein Kinase MER (cluster #1 Of 1), Eukaryotic Eukaryotes 2800 0.29 Binding ≤ 10μM
MET-1-E Hepatocyte Growth Factor Receptor (cluster #1 Of 1), Eukaryotic Eukaryotes 650 0.32 Binding ≤ 10μM
MK04-1-E Mitogen-activated Protein Kinase 4 (cluster #1 Of 1), Eukaryotic Eukaryotes 1600 0.30 Binding ≤ 10μM
MK06-1-E Mitogen-activated Protein Kinase 6 (cluster #1 Of 1), Eukaryotic Eukaryotes 480 0.33 Binding ≤ 10μM
MK07-1-E Mitogen-activated Protein Kinase 7 (cluster #1 Of 1), Eukaryotic Eukaryotes 520 0.33 Binding ≤ 10μM
MK08-1-E Mitogen-activated Protein Kinase 8 (cluster #1 Of 5), Eukaryotic Eukaryotes 1700 0.30 Binding ≤ 10μM
MK10-1-E C-Jun N-terminal Kinase 3 (cluster #1 Of 2), Eukaryotic Eukaryotes 1300 0.31 Binding ≤ 10μM
MK15-1-E Mitogen-activated Protein Kinase 15 (cluster #1 Of 1), Eukaryotic Eukaryotes 1100 0.31 Binding ≤ 10μM
MP2K1-1-E Dual Specificity Mitogen-activated Protein Kinase Kinase 1 (cluster #1 Of 4), Eukaryotic Eukaryotes 1800 0.30 Binding ≤ 10μM
MP2K2-1-E Dual Specificity Mitogen-activated Protein Kinase Kinase 2 (cluster #1 Of 1), Eukaryotic Eukaryotes 5600 0.27 Binding ≤ 10μM
MP2K3-1-E Dual Specificity Mitogen-activated Protein Kinase Kinase 3 (cluster #1 Of 1), Eukaryotic Eukaryotes 1500 0.30 Binding ≤ 10μM
MP2K4-1-E Dual Specificity Mitogen-activated Protein Kinase Kinase 4 (cluster #1 Of 1), Eukaryotic Eukaryotes 630 0.32 Binding ≤ 10μM
MP2K6-1-E Dual Specificity Mitogen-activated Protein Kinase Kinase 6 (cluster #1 Of 1), Eukaryotic Eukaryotes 1000 0.31 Binding ≤ 10μM
MST4-1-E Serine/threonine-protein Kinase MST4 (cluster #1 Of 1), Eukaryotic Eukaryotes 210 0.35 Binding ≤ 10μM
MYLK-1-E Myosin Light Chain Kinase, Smooth Muscle (cluster #1 Of 1), Eukaryotic Eukaryotes 2100 0.29 Binding ≤ 10μM
NUAK1-1-E NUAK Family SNF1-like Kinase 1 (cluster #1 Of 1), Eukaryotic Eukaryotes 180 0.35 Binding ≤ 10μM
NUAK2-1-E NUAK Family SNF1-like Kinase 2 (cluster #1 Of 1), Eukaryotic Eukaryotes 26 0.39 Binding ≤ 10μM
PAK3-1-E Serine/threonine-protein Kinase PAK 3 (cluster #1 Of 1), Eukaryotic Eukaryotes 2100 0.29 Binding ≤ 10μM
PAK4-1-E Serine/threonine-protein Kinase PAK 4 (cluster #1 Of 1), Eukaryotic Eukaryotes 2300 0.29 Binding ≤ 10μM
PAK6-1-E Serine/threonine-protein Kinase PAK6 (cluster #1 Of 1), Eukaryotic Eukaryotes 1400 0.30 Binding ≤ 10μM
PAK7-1-E Serine/threonine-protein Kinase PAK7 (cluster #1 Of 1), Eukaryotic Eukaryotes 830 0.32 Binding ≤ 10μM
PDPK1-1-E 3-phosphoinositide Dependent Protein Kinase-1 (cluster #1 Of 2), Eukaryotic Eukaryotes 3100 0.29 Binding ≤ 10μM
PGFRA-1-E Platelet-derived Growth Factor Receptor Alpha (cluster #1 Of 2), Eukaryotic Eukaryotes 4000 0.28 Binding ≤ 10μM
PGFRB-1-E Platelet-derived Growth Factor Receptor Beta (cluster #1 Of 1), Eukaryotic Eukaryotes 910 0.31 Binding ≤ 10μM
PI42B-1-E Phosphatidylinositol-5-phosphate 4-kinase Type-2 Beta (cluster #1 Of 1), Eukaryotic Eukaryotes 1300 0.31 Binding ≤ 10μM
PI51A-1-E Phosphatidylinositol-4-phosphate 5-kinase Type-1 Alpha (cluster #1 Of 1), Eukaryotic Eukaryotes 9200 0.26 Binding ≤ 10μM
PKN2-1-E Protein Kinase N2 (cluster #1 Of 1), Eukaryotic Eukaryotes 1900 0.30 Binding ≤ 10μM
PLK1-1-E Serine/threonine-protein Kinase PLK1 (cluster #1 Of 1), Eukaryotic Eukaryotes 5000 0.27 Binding ≤ 10μM
PLK3-1-E Serine/threonine-protein Kinase PLK3 (cluster #1 Of 1), Eukaryotic Eukaryotes 7100 0.27 Binding ≤ 10μM
PLK4-1-E Serine/threonine-protein Kinase PLK4 (cluster #1 Of 1), Eukaryotic Eukaryotes 120 0.36 Binding ≤ 10μM
RET-1-E Tyrosine-protein Kinase Receptor RET (cluster #1 Of 1), Eukaryotic Eukaryotes 4200 0.28 Binding ≤ 10μM
RIOK1-1-E Serine/threonine-protein Kinase RIO1 (cluster #1 Of 1), Eukaryotic Eukaryotes 1100 0.31 Binding ≤ 10μM
RIOK3-1-E Serine/threonine-protein Kinase RIO3 (cluster #1 Of 1), Eukaryotic Eukaryotes 1200 0.31 Binding ≤ 10μM
RIPK1-1-E Receptor-interacting Serine/threonine-protein Kinase 1 (cluster #1 Of 1), Eukaryotic Eukaryotes 1800 0.30 Binding ≤ 10μM
SIK1-1-E Serine/threonine-protein Kinase SIK1 (cluster #1 Of 1), Eukaryotic Eukaryotes 2200 0.29 Binding ≤ 10μM
SIK2-1-E Serine/threonine-protein Kinase SIK2 (cluster #1 Of 1), Eukaryotic Eukaryotes 1600 0.30 Binding ≤ 10μM
SLK-1-E Serine/threonine-protein Kinase 2 (cluster #1 Of 2), Eukaryotic Eukaryotes 48 0.38 Binding ≤ 10μM
SRPK1-1-E Serine/threonine-protein Kinase SRPK1 (cluster #1 Of 1), Eukaryotic Eukaryotes 2800 0.29 Binding ≤ 10μM
ST17A-1-E Serine/threonine-protein Kinase 17A (cluster #1 Of 2), Eukaryotic Eukaryotes 5600 0.27 Binding ≤ 10μM
STK10-1-E Serine/threonine-protein Kinase 10 (cluster #1 Of 1), Eukaryotic Eukaryotes 110 0.36 Binding ≤ 10μM
STK16-1-E Serine/threonine-protein Kinase 16 (cluster #1 Of 1), Eukaryotic Eukaryotes 140 0.36 Binding ≤ 10μM
STK24-1-E Serine/threonine-protein Kinase 24 (cluster #1 Of 1), Eukaryotic Eukaryotes 180 0.35 Binding ≤ 10μM
STK25-1-E Serine/threonine-protein Kinase 25 (cluster #1 Of 1), Eukaryotic Eukaryotes 360 0.33 Binding ≤ 10μM
STK3-1-E Serine/threonine-protein Kinase MST2 (cluster #1 Of 2), Eukaryotic Eukaryotes 61 0.37 Binding ≤ 10μM
STK4-1-E Serine/threonine-protein Kinase MST1 (cluster #1 Of 2), Eukaryotic Eukaryotes 130 0.36 Binding ≤ 10μM
TEC-1-E Tyrosine-protein Kinase TEC (cluster #1 Of 1), Eukaryotic Eukaryotes 1000 0.31 Binding ≤ 10μM
TESK1-1-E Dual Specificity Testis-specific Protein Kinase 1 (cluster #1 Of 1), Eukaryotic Eukaryotes 3100 0.29 Binding ≤ 10μM
TIE1-1-E Tyrosine-protein Kinase Receptor Tie-1 (cluster #1 Of 1), Eukaryotic Eukaryotes 260 0.34 Binding ≤ 10μM
TIE2-1-E Tyrosine-protein Kinase TIE-2 (cluster #1 Of 2), Eukaryotic Eukaryotes 950 0.31 Binding ≤ 10μM
TLK1-1-E Serine/threonine-protein Kinase Tousled-like 1 (cluster #1 Of 1), Eukaryotic Eukaryotes 1100 0.31 Binding ≤ 10μM
TLK2-1-E Serine/threonine-protein Kinase Tousled-like 2 (cluster #1 Of 1), Eukaryotic Eukaryotes 750 0.32 Binding ≤ 10μM
TNI3K-1-E Serine/threonine-protein Kinase TNNI3K (cluster #1 Of 1), Eukaryotic Eukaryotes 1400 0.30 Binding ≤ 10μM
TTK-1-E Dual Specificity Protein Kinase TTK (cluster #1 Of 2), Eukaryotic Eukaryotes 190 0.35 Binding ≤ 10μM
TYK2-1-E Tyrosine-protein Kinase TYK2 (cluster #1 Of 1), Eukaryotic Eukaryotes 32 0.39 Binding ≤ 10μM
UFO-1-E Tyrosine-protein Kinase Receptor UFO (cluster #1 Of 1), Eukaryotic Eukaryotes 2200 0.29 Binding ≤ 10μM
VGFR1-1-E Vascular Endothelial Growth Factor Receptor 1 (cluster #1 Of 1), Eukaryotic Eukaryotes 2100 0.29 Binding ≤ 10μM
VGFR2-1-E Vascular Endothelial Growth Factor Receptor 2 (cluster #1 Of 2), Eukaryotic Eukaryotes 3700 0.28 Binding ≤ 10μM
VGFR3-1-E Vascular Endothelial Growth Factor Receptor 3 (cluster #1 Of 2), Eukaryotic Eukaryotes 1100 0.31 Binding ≤ 10μM
Z104295-1-O Cyclin-dependent Kinase 4/cyclin D1 (cluster #1 Of 2), Other Other 110 0.36 Binding ≤ 10μM
Z80018-2-O A-375 (Malignant Melanoma Cells) (cluster #2 Of 4), Other Other 450 0.33 Functional ≤ 10μM
Z80390-1-O PC-3 (Prostate Carcinoma Cells) (cluster #1 Of 10), Other Other 120 0.36 Functional ≤ 10μM
Z80493-1-O SK-OV-3 (Ovarian Carcinoma Cells) (cluster #1 Of 6), Other Other 750 0.32 Functional ≤ 10μM
Z80928-3-O HCT-116 (Colon Carcinoma Cells) (cluster #3 Of 9), Other Other 254 0.34 Functional ≤ 10μM
Z81247-1-O HeLa (Cervical Adenocarcinoma Cells) (cluster #1 Of 9), Other Other 284 0.34 Functional ≤ 10μM
Z81252-3-O MDA-MB-231 (Breast Adenocarcinoma Cells) (cluster #3 Of 11), Other Other 590 0.32 Functional ≤ 10μM
ChEMBL Target Annotations
Uniprot Swissprot Description Affinity (nM) LE (kcal/mol/atom) Type
AAK1_HUMAN Q2M2I8 Adaptor-associated Kinase, Human 200 0.35 Binding ≤ 1μM
ANKK1_HUMAN Q8NFD2 Ankyrin Repeat And Protein Kinase Domain-containing Protein 1, Human 500 0.33 Binding ≤ 1μM
BMP2K_HUMAN Q9NSY1 BMP-2-inducible Protein Kinase, Human 180 0.35 Binding ≤ 1μM
BMPR2_HUMAN Q13873 Bone Morphogenetic Protein Receptor Type-2, Human 880 0.31 Binding ≤ 1μM
KC1G2_HUMAN P78368 Casein Kinase I Gamma 2, Human 740 0.32 Binding ≤ 1μM
CCNA1_HUMAN P78396 Cyclin A1, Human 2 0.45 Binding ≤ 1μM
CCNA2_HUMAN P20248 Cyclin A2, Human 2 0.45 Binding ≤ 1μM
CDK1_HUMAN P06493 Cyclin-dependent Kinase 1, Human 6 0.43 Binding ≤ 1μM
CDK2_HUMAN P24941 Cyclin-dependent Kinase 2, Human 2 0.45 Binding ≤ 1μM
CDK3_HUMAN Q00526 Cyclin-dependent Kinase 3, Human 180 0.35 Binding ≤ 1μM
Z104295 Z104295 Cyclin-dependent Kinase 4/cyclin D1 110 0.36 Binding ≤ 1μM
CDK5_HUMAN Q00535 Cyclin-dependent Kinase 5, Human 240 0.34 Binding ≤ 1μM
CDK7_HUMAN P50613 Cyclin-dependent Kinase 7, Human 760 0.32 Binding ≤ 1μM
CDK9_HUMAN P50750 Cyclin-dependent Kinase 9, Human 470 0.33 Binding ≤ 1μM
MP2K4_HUMAN P45985 Dual Specificity Mitogen-activated Protein Kinase Kinase 4, Human 630 0.32 Binding ≤ 1μM
MP2K6_HUMAN P52564 Dual Specificity Mitogen-activated Protein Kinase Kinase 6, Human 1000 0.31 Binding ≤ 1μM
CLK2_HUMAN P49760 Dual Specificity Protein Kinase CLK2, Human 290 0.34 Binding ≤ 1μM
CLK3_HUMAN P49761 Dual Specificity Protein Kinase CLK3, Human 310 0.34 Binding ≤ 1μM
TTK_HUMAN P33981 Dual Specificity Protein Kinase TTK, Human 190 0.35 Binding ≤ 1μM
CLK1_HUMAN P49759 Dual Specificty Protein Kinase CLK1, Human 660 0.32 Binding ≤ 1μM
FGFR1_HUMAN P11362 Fibroblast Growth Factor Receptor 1, Human 810 0.32 Binding ≤ 1μM
FGFR2_HUMAN P21802 Fibroblast Growth Factor Receptor 2, Human 220 0.35 Binding ≤ 1μM
FGFR3_HUMAN P22607 Fibroblast Growth Factor Receptor 3, Human 510 0.33 Binding ≤ 1μM
CCNB1_HUMAN P14635 G2/mitotic-specific Cyclin B1, Human 6 0.43 Binding ≤ 1μM
CCNB2_HUMAN O95067 G2/mitotic-specific Cyclin B2, Human 6 0.43 Binding ≤ 1μM
CCNB3_HUMAN Q8WWL7 G2/mitotic-specific Cyclin B3, Human 6 0.43 Binding ≤ 1μM
GSK3A_HUMAN P49840 Glycogen Synthase Kinase-3 Alpha, Human 160 0.35 Binding ≤ 1μM
GSK3B_HUMAN P49841 Glycogen Synthase Kinase-3 Beta, Human 41 0.38 Binding ≤ 1μM
MET_HUMAN P08581 Hepatocyte Growth Factor Receptor, Human 650 0.32 Binding ≤ 1μM
LIMK1_HUMAN P53667 LIM Domain Kinase 1, Human 620 0.32 Binding ≤ 1μM
LIMK2_HUMAN P53671 LIM Domain Kinase 2, Human 1000 0.31 Binding ≤ 1μM
MARK4_HUMAN Q96L34 MAP/microtubule Affinity-regulating Kinase 4, Human 660 0.32 Binding ≤ 1μM
MK06_HUMAN Q16659 Mitogen-activated Protein Kinase 6, Human 480 0.33 Binding ≤ 1μM
MK07_HUMAN Q13164 Mitogen-activated Protein Kinase 7, Human 520 0.33 Binding ≤ 1μM
M4K1_HUMAN Q92918 Mitogen-activated Protein Kinase Kinase Kinase Kinase 1, Human 120 0.36 Binding ≤ 1μM
M4K3_HUMAN Q8IVH8 Mitogen-activated Protein Kinase Kinase Kinase Kinase 3, Human 820 0.32 Binding ≤ 1μM
NUAK1_HUMAN O60285 NUAK Family SNF1-like Kinase 1, Human 180 0.35 Binding ≤ 1μM
NUAK2_HUMAN Q9H093 NUAK Family SNF1-like Kinase 2, Human 26 0.39 Binding ≤ 1μM
CD11B_HUMAN P21127 PITSLRE Serine/threonine-protein Kinase CDC2L1, Human 150 0.35 Binding ≤ 1μM
CD11A_HUMAN Q9UQ88 PITSLRE Serine/threonine-protein Kinase CDC2L2, Human 110 0.36 Binding ≤ 1μM
PGFRB_HUMAN P09619 Platelet-derived Growth Factor Receptor Beta, Human 910 0.31 Binding ≤ 1μM
KS6A2_HUMAN Q15349 Ribosomal Protein S6 Kinase Alpha 2, Human 410 0.33 Binding ≤ 1μM
STK10_HUMAN O94804 Serine/threonine-protein Kinase 10, Human 110 0.36 Binding ≤ 1μM
STK16_HUMAN O75716 Serine/threonine-protein Kinase 16, Human 140 0.36 Binding ≤ 1μM
SLK_HUMAN Q9H2G2 Serine/threonine-protein Kinase 2, Human 48 0.38 Binding ≤ 1μM
STK24_HUMAN Q9Y6E0 Serine/threonine-protein Kinase 24, Human 180 0.35 Binding ≤ 1μM
STK25_HUMAN O00506 Serine/threonine-protein Kinase 25, Human 360 0.33 Binding ≤ 1μM
AURKA_HUMAN O14965 Serine/threonine-protein Kinase Aurora-A, Human 250 0.34 Binding ≤ 1μM
AURKB_HUMAN Q96GD4 Serine/threonine-protein Kinase Aurora-B, Human 160 0.35 Binding ≤ 1μM
AURKC_HUMAN Q9UQB9 Serine/threonine-protein Kinase Aurora-C, Human 86 0.37 Binding ≤ 1μM
MARK3_HUMAN P27448 Serine/threonine-protein Kinase C-TAK1, Human 600 0.32 Binding ≤ 1μM
MARK1_HUMAN Q9P0L2 Serine/threonine-protein Kinase MARK1, Human 620 0.32 Binding ≤ 1μM
STK4_HUMAN Q13043 Serine/threonine-protein Kinase MST1, Human 130 0.36 Binding ≤ 1μM
STK3_HUMAN Q13188 Serine/threonine-protein Kinase MST2, Human 61 0.37 Binding ≤ 1μM
MST4_HUMAN Q9P289 Serine/threonine-protein Kinase MST4, Human 210 0.35 Binding ≤ 1μM
PAK7_HUMAN Q9P286 Serine/threonine-protein Kinase PAK7, Human 830 0.32 Binding ≤ 1μM
CDK16_HUMAN Q00536 Serine/threonine-protein Kinase PCTAIRE-1, Human 23 0.40 Binding ≤ 1μM
CDK17_HUMAN Q00537 Serine/threonine-protein Kinase PCTAIRE-2, Human 290 0.34 Binding ≤ 1μM
PLK4_HUMAN O00444 Serine/threonine-protein Kinase PLK4, Human 120 0.36 Binding ≤ 1μM
TLK2_HUMAN Q86UE8 Serine/threonine-protein Kinase Tousled-like 2, Human 750 0.32 Binding ≤ 1μM
KIT_HUMAN P10721 Stem Cell Growth Factor Receptor, Human 590 0.32 Binding ≤ 1μM
ABL1_HUMAN P00519 Tyrosine-protein Kinase ABL, Human 68 0.37 Binding ≤ 1μM
JAK1_HUMAN P23458 Tyrosine-protein Kinase JAK1, Human 21 0.40 Binding ≤ 1μM
JAK2_HUMAN O60674 Tyrosine-protein Kinase JAK2, Human 220 0.35 Binding ≤ 1μM
JAK3_HUMAN P52333 Tyrosine-protein Kinase JAK3, Human 180 0.35 Binding ≤ 1μM
FLT3_HUMAN P36888 Tyrosine-protein Kinase Receptor FLT3, Human 590 0.32 Binding ≤ 1μM
RET_HUMAN P07949 Tyrosine-protein Kinase Receptor RET, Human 1000 0.31 Binding ≤ 1μM
TIE1_HUMAN P35590 Tyrosine-protein Kinase Receptor Tie-1, Human 260 0.34 Binding ≤ 1μM
TEC_HUMAN P42680 Tyrosine-protein Kinase TEC, Human 1000 0.31 Binding ≤ 1μM
TIE2_HUMAN Q02763 Tyrosine-protein Kinase TIE-2, Human 950 0.31 Binding ≤ 1μM
TYK2_HUMAN P29597 Tyrosine-protein Kinase TYK2, Human 32 0.39 Binding ≤ 1μM
VGFR2_HUMAN P35968 Vascular Endothelial Growth Factor Receptor 2, Human 130 0.36 Binding ≤ 1μM
VGFR2_MOUSE P35918 Vascular Endothelial Growth Factor Receptor 2, Mouse 130 0.36 Binding ≤ 1μM
PDPK1_HUMAN O15530 3-phosphoinositide Dependent Protein Kinase-1, Human 3100 0.29 Binding ≤ 10μM
ACVR1_HUMAN Q04771 Activin Receptor Type-1, Human 5900 0.27 Binding ≤ 10μM
AVR2A_HUMAN P27037 Activin Receptor Type-2A, Human 2900 0.29 Binding ≤ 10μM
AVR2B_HUMAN Q13705 Activin Receptor Type-2B, Human 5900 0.27 Binding ≤ 10μM
AAK1_HUMAN Q2M2I8 Adaptor-associated Kinase, Human 200 0.35 Binding ≤ 10μM
ALK_HUMAN Q9UM73 ALK Tyrosine Kinase Receptor, Human 7100 0.27 Binding ≤ 10μM
AAPK1_HUMAN Q13131 AMP-activated Protein Kinase, Alpha-1 Subunit, Human 1700 0.30 Binding ≤ 10μM
AAPK2_HUMAN P54646 AMP-activated Protein Kinase, Alpha-2 Subunit, Human 1800 0.30 Binding ≤ 10μM
ANKK1_HUMAN Q8NFD2 Ankyrin Repeat And Protein Kinase Domain-containing Protein 1, Human 500 0.33 Binding ≤ 10μM
BMP2K_HUMAN Q9NSY1 BMP-2-inducible Protein Kinase, Human 180 0.35 Binding ≤ 10μM
BMPR2_HUMAN Q13873 Bone Morphogenetic Protein Receptor Type-2, Human 880 0.31 Binding ≤ 10μM
BRSK1_HUMAN Q8TDC3 BR Serine/threonine-protein Kinase 1, Human 6500 0.27 Binding ≤ 10μM
BRSK2_HUMAN Q8IWQ3 BR Serine/threonine-protein Kinase 2, Human 2700 0.29 Binding ≤ 10μM
MK08_HUMAN P45983 C-Jun N-terminal Kinase 1, Human 1700 0.30 Binding ≤ 10μM
MK10_HUMAN P53779 C-Jun N-terminal Kinase 3, Human 1300 0.31 Binding ≤ 10μM
KKCC1_HUMAN Q8N5S9 CaM-kinase Kinase Alpha, Human 2900 0.29 Binding ≤ 10μM
KKCC2_HUMAN Q96RR4 CaM-kinase Kinase Beta, Human 2600 0.29 Binding ≤ 10μM
KC1E_HUMAN P49674 Casein Kinase I Epsilon, Human 3600 0.28 Binding ≤ 10μM
KC1G1_HUMAN Q9HCP0 Casein Kinase I Gamma 1, Human 1200 0.31 Binding ≤ 10μM
KC1G2_HUMAN P78368 Casein Kinase I Gamma 2, Human 740 0.32 Binding ≤ 10μM
KC1G3_HUMAN Q9Y6M4 Casein Kinase I Isoform Gamma-3, Human 7900 0.26 Binding ≤ 10μM
CSK22_HUMAN P19784 Casein Kinase II Alpha (prime), Human 2000 0.30 Binding ≤ 10μM
ADCK3_HUMAN Q8NI60 Chaperone Activity Of Bc1 Complex-like, Mitochondrial, Human 1200 0.31 Binding ≤ 10μM
CCNA1_HUMAN P78396 Cyclin A1, Human 2 0.45 Binding ≤ 10μM
CCNA2_HUMAN P20248 Cyclin A2, Human 2 0.45 Binding ≤ 10μM
CDK1_HUMAN P06493 Cyclin-dependent Kinase 1, Human 6 0.43 Binding ≤ 10μM
CDK2_HUMAN P24941 Cyclin-dependent Kinase 2, Human 2 0.45 Binding ≤ 10μM
CDK3_HUMAN Q00526 Cyclin-dependent Kinase 3, Human 180 0.35 Binding ≤ 10μM
Z104295 Z104295 Cyclin-dependent Kinase 4/cyclin D1 110 0.36 Binding ≤ 10μM
CDK5_HUMAN Q00535 Cyclin-dependent Kinase 5, Human 240 0.34 Binding ≤ 10μM
CDK7_HUMAN P50613 Cyclin-dependent Kinase 7, Human 760 0.32 Binding ≤ 10μM
CDK9_HUMAN P50750 Cyclin-dependent Kinase 9, Human 470 0.33 Binding ≤ 10μM
DAPK3_HUMAN O43293 Death-associated Protein Kinase 3, Human 5200 0.27 Binding ≤ 10μM
MP2K1_HUMAN Q02750 Dual Specificity Mitogen-activated Protein Kinase Kinase 1, Human 1800 0.30 Binding ≤ 10μM
MP2K2_HUMAN P36507 Dual Specificity Mitogen-activated Protein Kinase Kinase 2, Human 5600 0.27 Binding ≤ 10μM
MP2K3_HUMAN P46734 Dual Specificity Mitogen-activated Protein Kinase Kinase 3, Human 1500 0.30 Binding ≤ 10μM
MP2K4_HUMAN P45985 Dual Specificity Mitogen-activated Protein Kinase Kinase 4, Human 630 0.32 Binding ≤ 10μM
MP2K6_HUMAN P52564 Dual Specificity Mitogen-activated Protein Kinase Kinase 6, Human 1000 0.31 Binding ≤ 10μM
CLK2_HUMAN P49760 Dual Specificity Protein Kinase CLK2, Human 290 0.34 Binding ≤ 10μM
CLK3_HUMAN P49761 Dual Specificity Protein Kinase CLK3, Human 310 0.34 Binding ≤ 10μM
CLK4_HUMAN Q9HAZ1 Dual Specificity Protein Kinase CLK4, Human 1700 0.30 Binding ≤ 10μM
TTK_HUMAN P33981 Dual Specificity Protein Kinase TTK, Human 190 0.35 Binding ≤ 10μM
TESK1_HUMAN Q15569 Dual Specificity Testis-specific Protein Kinase 1, Human 3100 0.29 Binding ≤ 10μM
CLK1_HUMAN P49759 Dual Specificty Protein Kinase CLK1, Human 660 0.32 Binding ≤ 10μM
EPHA7_HUMAN Q15375 Ephrin Type-A Receptor 7, Human 3100 0.29 Binding ≤ 10μM
E2AK4_HUMAN Q9P2K8 Eukaryotic Translation Initiation Factor 2-alpha Kinase 4, Human 3900 0.28 Binding ≤ 10μM
FGFR1_HUMAN P11362 Fibroblast Growth Factor Receptor 1, Human 810 0.32 Binding ≤ 10μM
FGFR2_HUMAN P21802 Fibroblast Growth Factor Receptor 2, Human 220 0.35 Binding ≤ 10μM
FGFR3_HUMAN P22607 Fibroblast Growth Factor Receptor 3, Human 510 0.33 Binding ≤ 10μM
CCNB1_HUMAN P14635 G2/mitotic-specific Cyclin B1, Human 6 0.43 Binding ≤ 10μM
CCNB2_HUMAN O95067 G2/mitotic-specific Cyclin B2, Human 6 0.43 Binding ≤ 10μM
CCNB3_HUMAN Q8WWL7 G2/mitotic-specific Cyclin B3, Human 6 0.43 Binding ≤ 10μM
GSK3A_HUMAN P49840 Glycogen Synthase Kinase-3 Alpha, Human 160 0.35 Binding ≤ 10μM
GSK3B_HUMAN P49841 Glycogen Synthase Kinase-3 Beta, Human 41 0.38 Binding ≤ 10μM
MET_HUMAN P08581 Hepatocyte Growth Factor Receptor, Human 650 0.32 Binding ≤ 10μM
IKKE_HUMAN Q14164 Inhibitor Of Nuclear Factor Kappa B Kinase Epsilon Subunit, Human 8300 0.26 Binding ≤ 10μM
E2AK2_HUMAN P19525 Interferon-induced, Double-stranded RNA-activated Protein Kinase, Human 6300 0.27 Binding ≤ 10μM
IRAK3_HUMAN Q9Y616 Interleukin-1 Receptor-associated Kinase 3, Human 3400 0.28 Binding ≤ 10μM
LIMK1_HUMAN P53667 LIM Domain Kinase 1, Human 620 0.32 Binding ≤ 10μM
LIMK2_HUMAN P53671 LIM Domain Kinase 2, Human 1000 0.31 Binding ≤ 10μM
CSF1R_HUMAN P07333 Macrophage Colony Stimulating Factor Receptor, Human 4200 0.28 Binding ≤ 10μM
MARK2_HUMAN Q7KZI7 MAP/microtubule Affinity-regulating Kinase 2, Human 1200 0.31 Binding ≤ 10μM
MARK4_HUMAN Q96L34 MAP/microtubule Affinity-regulating Kinase 4, Human 660 0.32 Binding ≤ 10μM
MK15_HUMAN Q8TD08 Mitogen-activated Protein Kinase 15, Human 1100 0.31 Binding ≤ 10μM
MK04_HUMAN P31152 Mitogen-activated Protein Kinase 4, Human 1600 0.30 Binding ≤ 10μM
MK06_HUMAN Q16659 Mitogen-activated Protein Kinase 6, Human 480 0.33 Binding ≤ 10μM
MK07_HUMAN Q13164 Mitogen-activated Protein Kinase 7, Human 520 0.33 Binding ≤ 10μM
M3K9_HUMAN P80192 Mitogen-activated Protein Kinase Kinase Kinase 9, Human 3600 0.28 Binding ≤ 10μM
M4K1_HUMAN Q92918 Mitogen-activated Protein Kinase Kinase Kinase Kinase 1, Human 120 0.36 Binding ≤ 10μM
M4K3_HUMAN Q8IVH8 Mitogen-activated Protein Kinase Kinase Kinase Kinase 3, Human 820 0.32 Binding ≤ 10μM
M4K5_HUMAN Q9Y4K4 Mitogen-activated Protein Kinase Kinase Kinase Kinase 5, Human 2100 0.29 Binding ≤ 10μM
MYLK_HUMAN Q15746 Myosin Light Chain Kinase, Smooth Muscle, Human 2100 0.29 Binding ≤ 10μM
DMPK_HUMAN Q09013 Myotonin-protein Kinase, Human 1200 0.31 Binding ≤ 10μM
NUAK1_HUMAN O60285 NUAK Family SNF1-like Kinase 1, Human 180 0.35 Binding ≤ 10μM
NUAK2_HUMAN Q9H093 NUAK Family SNF1-like Kinase 2, Human 26 0.39 Binding ≤ 10μM
PI51A_HUMAN Q99755 Phosphatidylinositol-4-phosphate 5-kinase Type-1 Alpha, Human 9200 0.26 Binding ≤ 10μM
PI42B_HUMAN P78356 Phosphatidylinositol-5-phosphate 4-kinase Type-2 Beta, Human 1300 0.31 Binding ≤ 10μM
CD11B_HUMAN P21127 PITSLRE Serine/threonine-protein Kinase CDC2L1, Human 150 0.35 Binding ≤ 10μM
CD11A_HUMAN Q9UQ88 PITSLRE Serine/threonine-protein Kinase CDC2L2, Human 110 0.36 Binding ≤ 10μM
PGFRA_HUMAN P16234 Platelet-derived Growth Factor Receptor Alpha, Human 4000 0.28 Binding ≤ 10μM
PGFRB_HUMAN P09619 Platelet-derived Growth Factor Receptor Beta, Human 910 0.31 Binding ≤ 10μM
KPCD_HUMAN Q05655 Protein Kinase C Delta, Human 4500 0.28 Binding ≤ 10μM
KPCD1_HUMAN Q15139 Protein Kinase C Mu, Human 8400 0.26 Binding ≤ 10μM
KPCD3_HUMAN O94806 Protein Kinase C Nu, Human 4200 0.28 Binding ≤ 10μM
KPCT_HUMAN Q04759 Protein Kinase C Theta, Human 4400 0.28 Binding ≤ 10μM
PKN2_HUMAN Q16513 Protein Kinase N2, Human 1900 0.30 Binding ≤ 10μM
MERTK_HUMAN Q12866 Proto-oncogene Tyrosine-protein Kinase MER, Human 2800 0.29 Binding ≤ 10μM
RIPK1_HUMAN Q13546 Receptor-interacting Serine/threonine-protein Kinase 1, Human 1800 0.30 Binding ≤ 10μM
KS6A1_HUMAN Q15418 Ribosomal Protein S6 Kinase Alpha 1, Human 4000 0.28 Binding ≤ 10μM
KS6A2_HUMAN Q15349 Ribosomal Protein S6 Kinase Alpha 2, Human 410 0.33 Binding ≤ 10μM
KS6A4_HUMAN O75676 Ribosomal Protein S6 Kinase Alpha 4, Human 3000 0.29 Binding ≤ 10μM
STK10_HUMAN O94804 Serine/threonine-protein Kinase 10, Human 110 0.36 Binding ≤ 10μM
STK16_HUMAN O75716 Serine/threonine-protein Kinase 16, Human 140 0.36 Binding ≤ 10μM
ST17A_HUMAN Q9UEE5 Serine/threonine-protein Kinase 17A, Human 5600 0.27 Binding ≤ 10μM
SLK_HUMAN Q9H2G2 Serine/threonine-protein Kinase 2, Human 48 0.38 Binding ≤ 10μM
STK24_HUMAN Q9Y6E0 Serine/threonine-protein Kinase 24, Human 180 0.35 Binding ≤ 10μM
STK25_HUMAN O00506 Serine/threonine-protein Kinase 25, Human 360 0.33 Binding ≤ 10μM
AURKA_HUMAN O14965 Serine/threonine-protein Kinase Aurora-A, Human 250 0.34 Binding ≤ 10μM
AURKB_HUMAN Q96GD4 Serine/threonine-protein Kinase Aurora-B, Human 160 0.35 Binding ≤ 10μM
AURKC_HUMAN Q9UQB9 Serine/threonine-protein Kinase Aurora-C, Human 86 0.37 Binding ≤ 10μM
MARK3_HUMAN P27448 Serine/threonine-protein Kinase C-TAK1, Human 600 0.32 Binding ≤ 10μM
DCLK1_HUMAN O15075 Serine/threonine-protein Kinase DCLK1, Human 2500 0.29 Binding ≤ 10μM
DCLK2_HUMAN Q8N568 Serine/threonine-protein Kinase DCLK2, Human 4500 0.28 Binding ≤ 10μM
DCLK3_HUMAN Q9C098 Serine/threonine-protein Kinase DCLK3, Human 6500 0.27 Binding ≤ 10μM
GAK_HUMAN O14976 Serine/threonine-protein Kinase GAK, Human 2400 0.29 Binding ≤ 10μM
MARK1_HUMAN Q9P0L2 Serine/threonine-protein Kinase MARK1, Human 620 0.32 Binding ≤ 10μM
STK4_HUMAN Q13043 Serine/threonine-protein Kinase MST1, Human 130 0.36 Binding ≤ 10μM
STK3_HUMAN Q13188 Serine/threonine-protein Kinase MST2, Human 61 0.37 Binding ≤ 10μM
MST4_HUMAN Q9P289 Serine/threonine-protein Kinase MST4, Human 210 0.35 Binding ≤ 10μM
PAK3_HUMAN O75914 Serine/threonine-protein Kinase PAK 3, Human 2100 0.29 Binding ≤ 10μM
PAK4_HUMAN O96013 Serine/threonine-protein Kinase PAK 4, Human 2300 0.29 Binding ≤ 10μM
PAK6_HUMAN Q9NQU5 Serine/threonine-protein Kinase PAK6, Human 1400 0.30 Binding ≤ 10μM
PAK7_HUMAN Q9P286 Serine/threonine-protein Kinase PAK7, Human 830 0.32 Binding ≤ 10μM
CDK16_HUMAN Q00536 Serine/threonine-protein Kinase PCTAIRE-1, Human 23 0.40 Binding ≤ 10μM
CDK17_HUMAN Q00537 Serine/threonine-protein Kinase PCTAIRE-2, Human 290 0.34 Binding ≤ 10μM
CDK18_HUMAN Q07002 Serine/threonine-protein Kinase PCTAIRE-3, Human 2100 0.29 Binding ≤ 10μM
CDK14_HUMAN O94921 Serine/threonine-protein Kinase PFTAIRE-1, Human 3600 0.28 Binding ≤ 10μM
PLK1_HUMAN P53350 Serine/threonine-protein Kinase PLK1, Human 5000 0.27 Binding ≤ 10μM
PLK3_HUMAN Q9H4B4 Serine/threonine-protein Kinase PLK3, Human 7100 0.27 Binding ≤ 10μM
PLK4_HUMAN O00444 Serine/threonine-protein Kinase PLK4, Human 120 0.36 Binding ≤ 10μM
ACVL1_HUMAN P37023 Serine/threonine-protein Kinase Receptor R3, Human 2900 0.29 Binding ≤ 10μM
RIOK1_HUMAN Q9BRS2 Serine/threonine-protein Kinase RIO1, Human 1100 0.31 Binding ≤ 10μM
RIOK3_HUMAN O14730 Serine/threonine-protein Kinase RIO3, Human 1200 0.31 Binding ≤ 10μM
SIK1_HUMAN P57059 Serine/threonine-protein Kinase SIK1, Human 2200 0.29 Binding ≤ 10μM
SIK2_HUMAN Q9H0K1 Serine/threonine-protein Kinase SIK2, Human 1600 0.30 Binding ≤ 10μM
SRPK1_HUMAN Q96SB4 Serine/threonine-protein Kinase SRPK1, Human 2800 0.29 Binding ≤ 10μM
TNI3K_HUMAN Q59H18 Serine/threonine-protein Kinase TNNI3K, Human 1400 0.30 Binding ≤ 10μM
TLK1_HUMAN Q9UKI8 Serine/threonine-protein Kinase Tousled-like 1, Human 1100 0.31 Binding ≤ 10μM
TLK2_HUMAN Q86UE8 Serine/threonine-protein Kinase Tousled-like 2, Human 750 0.32 Binding ≤ 10μM
KIT_HUMAN P10721 Stem Cell Growth Factor Receptor, Human 1400 0.30 Binding ≤ 10μM
ABL1_HUMAN P00519 Tyrosine-protein Kinase ABL, Human 1200 0.31 Binding ≤ 10μM
BMX_HUMAN P51813 Tyrosine-protein Kinase BMX, Human 4700 0.28 Binding ≤ 10μM
FGR_HUMAN P09769 Tyrosine-protein Kinase FGR, Human 2000 0.30 Binding ≤ 10μM
JAK1_HUMAN P23458 Tyrosine-protein Kinase JAK1, Human 21 0.40 Binding ≤ 10μM
JAK2_HUMAN O60674 Tyrosine-protein Kinase JAK2, Human 220 0.35 Binding ≤ 10μM
JAK3_HUMAN P52333 Tyrosine-protein Kinase JAK3, Human 180 0.35 Binding ≤ 10μM
FLT3_HUMAN P36888 Tyrosine-protein Kinase Receptor FLT3, Human 1400 0.30 Binding ≤ 10μM
RET_HUMAN P07949 Tyrosine-protein Kinase Receptor RET, Human 1000 0.31 Binding ≤ 10μM
TIE1_HUMAN P35590 Tyrosine-protein Kinase Receptor Tie-1, Human 260 0.34 Binding ≤ 10μM
UFO_HUMAN P30530 Tyrosine-protein Kinase Receptor UFO, Human 2200 0.29 Binding ≤ 10μM
KSYK_HUMAN P43405 Tyrosine-protein Kinase SYK, Human 1300 0.31 Binding ≤ 10μM
TEC_HUMAN P42680 Tyrosine-protein Kinase TEC, Human 1000 0.31 Binding ≤ 10μM
TIE2_HUMAN Q02763 Tyrosine-protein Kinase TIE-2, Human 950 0.31 Binding ≤ 10μM
TYK2_HUMAN P29597 Tyrosine-protein Kinase TYK2, Human 32 0.39 Binding ≤ 10μM
VGFR1_HUMAN P17948 Vascular Endothelial Growth Factor Receptor 1, Human 2100 0.29 Binding ≤ 10μM
VGFR2_HUMAN P35968 Vascular Endothelial Growth Factor Receptor 2, Human 130 0.36 Binding ≤ 10μM
VGFR2_MOUSE P35918 Vascular Endothelial Growth Factor Receptor 2, Mouse 130 0.36 Binding ≤ 10μM
VGFR3_HUMAN P35916 Vascular Endothelial Growth Factor Receptor 3, Human 1100 0.31 Binding ≤ 10μM
Z80018 Z80018 A-375 (Malignant Melanoma Cells) 447 0.33 Functional ≤ 10μM
Z80928 Z80928 HCT-116 (Colon Carcinoma Cells) 250 0.34 Functional ≤ 10μM
Z81247 Z81247 HeLa (Cervical Adenocarcinoma Cells) 280 0.34 Functional ≤ 10μM
Z81252 Z81252 MDA-MB-231 (Breast Adenocarcinoma Cells) 590 0.32 Functional ≤ 10μM
Z80390 Z80390 PC-3 (Prostate Carcinoma Cells) 120 0.36 Functional ≤ 10μM
Z80493 Z80493 SK-OV-3 (Ovarian Carcinoma Cells) 750 0.32 Functional ≤ 10μM

Reactome Annotations from Targets (via Uniprot)

Description Species
Activated point mutants of FGFR2
activated TAK1 mediates p38 MAPK activation
Activation of ATR in response to replication stress
Activation of BIM and translocation to mitochondria
Activation of BMF and translocation to mitochondria
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
Activation of NIMA Kinases NEK9, NEK6, NEK7
Activation of PKB
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
Activation of Rac
Activation of the AP-1 family of transcription factors
Activation of the pre-replicative complex
AKT phosphorylates targets in the cytosol
AMPK inhibits chREBP transcriptional activation activity
Antigen activates B Cell Receptor (BCR) leading to generation of second messenge
APC truncation mutants have impaired AXIN binding
APC/C:Cdc20 mediated degradation of Cyclin B
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins
Apoptotic cleavage of cellular proteins
Apoptotic execution phase
AXIN missense mutants destabilize the destruction complex
Beta-catenin phosphorylation cascade
Calmodulin induced events
Caspase-8 activation by cleavage
CD28 dependent PI3K/Akt signaling
CD28 dependent Vav1 pathway
CDK-mediated phosphorylation and removal of Cdc6
CDO in myogenesis
Cell surface interactions at the vascular wall
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
Circadian Clock
Condensation of Prometaphase Chromosomes
Condensation of Prophase Chromosomes
Constitutive PI3K/AKT Signaling in Cancer
CREB phosphorylation
CREB phosphorylation through the activation of CaMKK
CREB phosphorylation through the activation of Ras
CRMPs in Sema3A signaling
CTLA4 inhibitory signaling
Cyclin A/B1 associated events during G2/M transition
Cyclin A:Cdk2-associated events at S phase entry
Cyclin B2 mediated events
Cyclin D associated events in G1
Cyclin E associated events during G1/S transition
DAG and IP3 signaling
DAP12 signaling
DARPP-32 events
Degradation of beta-catenin by the destruction complex
Depolymerisation of the Nuclear Lamina
Dimerization of procaspase-8
disassembly of the destruction complex and recruitment of AXIN to the membrane
DNA Damage/Telomere Stress Induced Senescence
Downstream signal transduction
Downstream TCR signaling
DSCAM interactions
Dual incision reaction in GG-NER
Dual incision reaction in TC-NER
E2F mediated regulation of DNA replication
E2F-enabled inhibition of pre-replication complex formation
Effects of PIP2 hydrolysis
EPH-ephrin mediated repulsion of cells
EPH-Ephrin signaling
EPHA-mediated growth cone collapse
EPHB-mediated forward signaling
Ephrin signaling
ERK/MAPK targets
ERK1 activation
ERK2 activation
ERKs are inactivated
Factors involved in megakaryocyte development and platelet production
Fc epsilon receptor (FCERI) signaling
FCERI mediated Ca+2 mobilization
FCERI mediated MAPK activation
FCERI mediated NF-kB activation
FCGR activation
Formation of HIV elongation complex in the absence of HIV Tat
Formation of HIV-1 elongation complex containing HIV-1 Tat
Formation of incision complex in GG-NER
Formation of RNA Pol II elongation complex
Formation of the Early Elongation Complex
Formation of the HIV-1 Early Elongation Complex
Formation of transcription-coupled NER (TC-NER) repair complex
G alpha (z) signalling events
G beta:gamma signalling through PI3Kgamma
G0 and Early G1
G1/S-Specific Transcription
G2 Phase
G2/M DNA replication checkpoint
Gastrin-CREB signalling pathway via PKC and MAPK
Generation of second messenger molecules
Golgi Associated Vesicle Biogenesis
Golgi Cisternae Pericentriolar Stack Reorganization
GPVI-mediated activation cascade
Growth hormone receptor signaling
HIV elongation arrest and recovery
HIV Transcription Initiation
HuR stabilizes mRNA
IKK complex recruitment mediated by RIP1
Import of palmitoyl-CoA into the mitochondrial matrix
Inactivation, recovery and regulation of the phototransduction cascade
Inhibition of PKR
Integrin alphaIIb beta3 signaling
Integrin cell surface interactions
Interactions of Tat with host cellular proteins
Interferon alpha/beta signaling
Interferon gamma signaling
Interleukin receptor SHC signaling
Interleukin-1 signaling
Interleukin-2 signaling
Interleukin-3, 5 and GM-CSF signaling
Interleukin-6 signaling
Interleukin-7 signaling
ISG15 antiviral mechanism
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human
Loss of Nlp from mitotic centrosomes
Loss of proteins required for interphase microtubule organization from the ce
MASTL Facilitates Mitotic Progression
Meiotic recombination
MEK activation
misspliced GSK3beta mutants stabilize beta-catenin
Mitotic Metaphase/Anaphase Transition
Mitotic Prometaphase
Mitotic Telophase/Cytokinesis
mRNA Capping
MyD88:Mal cascade initiated on plasma membrane
Negative regulators of RIG-I/MDA5 signaling
Netrin-1 signaling
Neurophilin interactions with VEGF and VEGFR
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
NOD1/2 Signaling Pathway
NoRC negatively regulates rRNA expression
NRAGE signals death through JNK
NRIF signals cell death from the nucleus
Nuclear Pore Complex (NPC) Disassembly
Orc1 removal from chromatin
Oxidative Stress Induced Senescence
p53-Dependent G1 DNA Damage Response
Pausing and recovery of HIV elongation
Pausing and recovery of Tat-mediated HIV elongation
Phosphorylation of Emi1
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2
Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 com
Phosphorylation of the APC/C
PIP3 activates AKT signaling
Platelet sensitization by LDL
Polo-like kinase mediated events
Prolactin receptor signaling
RAF phosphorylates MEK
Recruitment of mitotic centrosome proteins and complexes
Recruitment of NuMA to mitotic centrosomes
Recycling pathway of L1
Regulation by c-FLIP
Regulation of actin dynamics for phagocytic cup formation
Regulation of AMPK activity via LKB1
Regulation of APC/C activators between G1/S and early anaphase
Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen
Regulation of HSF1-mediated heat shock response
Regulation of IFNA signaling
Regulation of IFNG signaling
Regulation of KIT signaling
Regulation of PLK1 Activity at G2/M Transition
Regulation of Rheb GTPase activity by AMPK
Regulation of signaling by CBL
Regulation of signaling by NODAL
Resolution of Sister Chromatid Cohesion
RIP-mediated NFkB activation via ZBP1
RMTs methylate histone arginines
RNA Pol II CTD phosphorylation and interaction with CE
RNA Polymerase I Chain Elongation
RNA Polymerase I Promoter Escape
RNA Polymerase I Transcription Initiation
RNA Polymerase I Transcription Termination
RNA Polymerase II HIV Promoter Escape
RNA Polymerase II Pre-transcription Events
RNA Polymerase II Promoter Escape
RNA Polymerase II Transcription Elongation
RNA Polymerase II Transcription Initiation
RNA Polymerase II Transcription Initiation And Promoter Clearance
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
Role of Abl in Robo-Slit signaling
Role of DCC in regulating apoptosis
Role of LAT2/NTAL/LAB on calcium mobilization
Role of phospholipids in phagocytosis
RSK activation
S33 mutants of beta-catenin aren't phosphorylated
S37 mutants of beta-catenin aren't phosphorylated
S45 mutants of beta-catenin aren't phosphorylated
SCF(Skp2)-mediated degradation of p27/p21
Sema3A PAK dependent Axon repulsion
Sema4D induced cell migration and growth-cone collapse
Sema4D mediated inhibition of cell attachment and migration
Senescence-Associated Secretory Phenotype (SASP)
Separation of Sister Chromatids
Signal transduction by L1
Signaling by activated point mutants of FGFR1
Signaling by activated point mutants of FGFR3
Signaling by Activin
Signaling by BMP
Signaling by FGFR
Signaling by FGFR mutants
Signaling by FGFR2 amplification mutants
Signaling by FGFR3 mutants
Signaling by Hippo
Signaling by Leptin
Signaling by NODAL
Signaling by PDGF
Signaling by SCF-KIT
Signalling to ERK5
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Smooth Muscle Contraction
Sphingolipid de novo biosynthesis
Synthesis of PIPs at the plasma membrane
t(4;14) translocations of FGFR3
T41 mutants of beta-catenin aren't phosphorylated
Tat-mediated elongation of the HIV-1 transcript
Tat-mediated HIV elongation arrest and recovery
Tie2 Signaling
TNF signaling
TRAF3-dependent IRF activation pathway
TRAF6 mediated IRF7 activation
Transcription of the HIV genome
Translocation of GLUT4 to the plasma membrane
TRIF-mediated programmed cell death
TRP channels
truncations of AMER1 destabilize the destruction complex
Uptake and function of anthrax toxins
VEGF binds to VEGFR leading to receptor dimerization
VEGFA-VEGFR2 Pathway
VEGFR2 mediated cell proliferation
VEGFR2 mediated vascular permeability
WNT mediated activation of DVL
XBP1(S) activates chaperone genes

Analogs ( Draw Identity 99% 90% 80% 70% )