| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| December 7th, 2005 | 29 | Yes |
Popular Name: prost- prost-
Find On: PubMed — Wikipedia — Google
CAS Numbers: 40665-92-7 , 54276-21-0 , 55028-72-3 , [54276-21-0] , [55028-72-3]
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 2.94 | 5.79 | -52.47 | 3 | 6 | -1 | 110 | 423.913 | 11 | ↓ |
| Lo Low (pH 4.5-6) | 2.94 | 3.82 | -12.28 | 4 | 6 | 0 | 107 | 424.921 | 11 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| PE2R1-2-E | Prostanoid EP1 Receptor (cluster #2 Of 2), Eukaryotic | Eukaryotes | 496 | 0.30 | Binding ≤ 10μM |
| PE2R2-2-E | Prostanoid EP2 Receptor (cluster #2 Of 2), Eukaryotic | Eukaryotes | 3700 | 0.26 | Binding ≤ 10μM |
| PE2R3-2-E | Prostanoid EP3 Receptor (cluster #2 Of 3), Eukaryotic | Eukaryotes | 635 | 0.30 | Binding ≤ 10μM |
| PF2R-1-E | Prostaglandin F2-alpha Receptor (cluster #1 Of 1), Eukaryotic | Eukaryotes | 31 | 0.36 | Binding ≤ 10μM |
| PE2R1-2-E | Prostanoid EP1 Receptor (cluster #2 Of 2), Eukaryotic | Eukaryotes | 760 | 0.30 | Functional ≤ 10μM |
| PE2R3-2-E | Prostanoid EP3 Receptor (cluster #2 Of 2), Eukaryotic | Eukaryotes | 5000 | 0.26 | Functional ≤ 10μM |
| PF2R-1-E | Prostaglandin F2-alpha Receptor (cluster #1 Of 1), Eukaryotic | Eukaryotes | 10 | 0.39 | Functional ≤ 10μM |
| TA2R-1-E | Thromboxane A2 Receptor (cluster #1 Of 1), Eukaryotic | Eukaryotes | 2400 | 0.27 | Functional ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| PE2R1_HUMAN | P34995 | Prostanoid EP1 Receptor, Human | 496 | 0.30 | Binding ≤ 1μM |
| PE2R3_HUMAN | P43115 | Prostanoid EP3 Receptor, Human | 635 | 0.30 | Binding ≤ 1μM |
| PF2R_HUMAN | P43088 | Prostanoid FP Receptor, Human | 1 | 0.43 | Binding ≤ 1μM |
| PE2R1_HUMAN | P34995 | Prostanoid EP1 Receptor, Human | 496 | 0.30 | Binding ≤ 10μM |
| PE2R2_HUMAN | P43116 | Prostanoid EP2 Receptor, Human | 3700 | 0.26 | Binding ≤ 10μM |
| PE2R3_HUMAN | P43115 | Prostanoid EP3 Receptor, Human | 635 | 0.30 | Binding ≤ 10μM |
| PF2R_HUMAN | P43088 | Prostanoid FP Receptor, Human | 1 | 0.43 | Binding ≤ 10μM |
| PE2R1_HUMAN | P34995 | Prostanoid EP1 Receptor, Human | 760 | 0.30 | Functional ≤ 10μM |
| PE2R3_HUMAN | P43115 | Prostanoid EP3 Receptor, Human | 5000 | 0.26 | Functional ≤ 10μM |
| PF2R_HUMAN | P43088 | Prostanoid FP Receptor, Human | 10 | 0.39 | Functional ≤ 10μM |
| TA2R_HUMAN | P21731 | Thromboxane A2 Receptor, Human | 2400 | 0.27 | Functional ≤ 10μM |
| Description | Species |
|---|---|
| G alpha (12/13) signalling events | |
| G alpha (i) signalling events | |
| G alpha (q) signalling events | |
| G alpha (s) signalling events | |
| Prostanoid ligand receptors | |
| Thromboxane signalling through TP receptor |
