| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| July 24th, 2004 | 25 | Yes |
Popular Name: Fenofibrate Fenofibrate
Find On: PubMed — Wikipedia — Google
CAS Numbers: , 49562-28-9 , [49562-28-9]
2-[4-(4-Chlorobenzoyl)phenoxy]-2-methylpropanoic acid isopropyl ester
49562-28-9; C07586; Fenofibrate
49562-28-9; CPD000058299; FENOFIBRATE; SAM002264613
49562-28-9; Fenofibrate; Prestwick_217
Antara, Fenoglide, Fibricor, Lipofen, Lofibra, Triglide
CPD000058299; Fenofibrate; SAM002264613
ct Arzneimittel Brand of Procetofen
ct-Arzneimittel Brand of Procetofen
Fenofibrate (Tricor, Trilipix)
Fenofibrato [INN-Spanish];Fenofibratum [INN-Latin];Fenofibric acid;Finofibrate;FNF
GNR Pharma Brand of Procetofen
GNR-Pharma Brand of Procetofen
Isopropyl 2-(4-(4-chlorobenzoyl)phenoxy)-2-methylpropanoate
Isopropyl 2-(4-(4-chlorobenzoyl)phenoxy)-2-methylpropionate
Isopropyl 2-(p-(p-chlorobenzoyl)phenoxy)-2-methylpropionate
isopropyl 2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropanoate
Lichtenstein Brand of Procetofen
Merck dura Brand of Procetofen
Pharmascience Brand of Procetofen
propanoic acid, 2-[4-(4-chlorobenzoyl)phenoxy]-2-methyl-, 1-methylethyl ester
ratiopharm Brand of Procetofen
Schering Plough Brand of Procetofen
Schering-Plough Brand of Procetofen
Stadapharm Brand of Procetofen
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 5.54 | 11.71 | -10.11 | 0 | 4 | 0 | 53 | 360.837 | 7 | ↓ |
| Note Type | Comments | Provided By |
|---|---|---|
| ALOGPS_SOLUBILITY | 7.07e-04 g/l | DrugBank-approved |
| Purity | 95% | Fluorochem |
| UniProt Database Links | ABCD1_MOUSE; AOXA_MOUSE; HYES_HUMAN; HYES_MOUSE; HYES_RAT; IL27A_MOUSE | ChEBI |
| Therapy | antihyperlipidemic | SMDC Iconix |
| Patent Database Links | EP1258253; EP1522310; EP1553091; EP1559419; EP1559710; EP1621200; EP1655037; EP1690530; EP1707196; EP1707197; EP1714648; EP1738757; EP1746099; EP1785133; EP1785144; EP1803441; EP1808163; EP1832576; EP1864680; EP1884513; EP1889847; EP1894567; EP1911462; EP | ChEBI |
| PUBCHEM_SUBSTANCE_COMMENT | NCC_SAMPLE_SUPPLIER : LightBiologicals; NCC_SUPPLIER_STRUCTURE_ID : F-3539 | NIH Clinical Collection via PubChem |
| Target | NULL | Selleck Chemicals |
| PUBCHEM_SUBSTANCE_COMMENT | SAMPLE_SUPPLIER: LightBiologicals; SUPPLIER_STRUCTURE_ID: F-3539 | NIH Clinical Collection via PubChem |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| FABPL-3-E | Fatty Acid-binding Protein, Liver (cluster #3 Of 4), Eukaryotic | Eukaryotes | 62 | 0.40 | Binding ≤ 10μM |
| PPARA-1-E | Peroxisome Proliferator-activated Receptor Alpha (cluster #1 Of 3), Eukaryotic | Eukaryotes | 3210 | 0.31 | Binding ≤ 10μM |
| PPARG-1-E | Peroxisome Proliferator-activated Receptor Gamma (cluster #1 Of 2), Eukaryotic | Eukaryotes | 570 | 0.35 | Binding ≤ 10μM |
| PPARA-1-E | Peroxisome Proliferator-activated Receptor Alpha (cluster #1 Of 2), Eukaryotic | Eukaryotes | 2000 | 0.32 | Functional ≤ 10μM |
| Z50425-1-O | Plasmodium Falciparum (cluster #1 Of 22), Other | Other | 7943 | 0.29 | Functional ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| FABPL_RAT | P02692 | Fatty Acid-binding Protein, Liver, Rat | 130 | 0.39 | Binding ≤ 1μM |
| PPARA_HUMAN | Q07869 | Peroxisome Proliferator-activated Receptor Alpha, Human | 1000 | 0.34 | Binding ≤ 1μM |
| PPARG_HUMAN | P37231 | Peroxisome Proliferator-activated Receptor Gamma, Human | 570 | 0.35 | Binding ≤ 1μM |
| FABPL_RAT | P02692 | Fatty Acid-binding Protein, Liver, Rat | 130 | 0.39 | Binding ≤ 10μM |
| PPARA_HUMAN | Q07869 | Peroxisome Proliferator-activated Receptor Alpha, Human | 1000 | 0.34 | Binding ≤ 10μM |
| PPARG_HUMAN | P37231 | Peroxisome Proliferator-activated Receptor Gamma, Human | 570 | 0.35 | Binding ≤ 10μM |
| PPARA_HUMAN | Q07869 | Peroxisome Proliferator-activated Receptor Alpha, Human | 2000 | 0.32 | Functional ≤ 10μM |
| Z50425 | Z50425 | Plasmodium Falciparum | 7943.28235 | 0.29 | Functional ≤ 10μM |
| Description | Species |
|---|---|
| Activation of gene expression by SREBF (SREBP) | |
| BMAL1:CLOCK,NPAS2 activates circadian gene expression | |
| Circadian Clock | |
| Nuclear Receptor transcription pathway | |
| PPARA activates gene expression | |
| Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alp | |
| REV-ERBA represses gene expression | |
| RORA activates circadian gene expression | |
| Transcriptional activation of mitochondrial biogenesis | |
| Transcriptional regulation of white adipocyte differentiation | |
| YAP1- and WWTR1 (TAZ)-stimulated gene expression |
