| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| September 25th, 2009 | 38 | No |
Popular Name: SR-973 SR-973
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 5.41 | 12.04 | -28.44 | 3 | 8 | 0 | 108 | 523.674 | 12 | ↓ |
| Note Type | Comments | Provided By |
|---|---|---|
| PUBCHEM_PATENT_ID | WO2000007995A1 | IBM Patent Data |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| ADA17-1-E | ADAM17 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 4 | 0.31 | Binding ≤ 10μM |
| MMP1-2-E | Matrix Metalloproteinase-1 (cluster #2 Of 2), Eukaryotic | Eukaryotes | 21 | 0.28 | Binding ≤ 10μM |
| MMP10-1-E | Matrix Metalloproteinase 10 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 190 | 0.25 | Binding ≤ 10μM |
| MMP13-1-E | Matrix Metalloproteinase 13 (cluster #1 Of 4), Eukaryotic | Eukaryotes | 10 | 0.29 | Binding ≤ 10μM |
| MMP14-1-E | Matrix Metalloproteinase 14 (cluster #1 Of 3), Eukaryotic | Eukaryotes | 1200 | 0.22 | Binding ≤ 10μM |
| MMP2-1-E | 72 KDa Type IV Collagenase (cluster #1 Of 3), Eukaryotic | Eukaryotes | 7 | 0.30 | Binding ≤ 10μM |
| MMP7-1-E | Matrix Metalloproteinase 7 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 660 | 0.23 | Binding ≤ 10μM |
| MMP9-2-E | Matrix Metalloproteinase 9 (cluster #2 Of 3), Eukaryotic | Eukaryotes | 5 | 0.31 | Binding ≤ 10μM |
| A4-1-E | Beta Amyloid A4 Protein (cluster #1 Of 1), Eukaryotic | Eukaryotes | 200 | 0.25 | Functional ≤ 10μM |
| Z80088-1-O | CHO (Ovarian Cells) (cluster #1 Of 4), Other | Other | 200 | 0.25 | Functional ≤ 10μM |
| Z80936-1-O | HEK293 (Embryonic Kidney Fibroblasts) (cluster #1 Of 4), Other | Other | 500 | 0.23 | Functional ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| ADA17_HUMAN | P78536 | ADAM17, Human | 4 | 0.31 | Binding ≤ 1μM |
| MMP10_HUMAN | P09238 | Matrix Metalloproteinase 10, Human | 190 | 0.25 | Binding ≤ 1μM |
| MMP13_HUMAN | P45452 | Matrix Metalloproteinase 13, Human | 10 | 0.29 | Binding ≤ 1μM |
| MMP7_HUMAN | P09237 | Matrix Metalloproteinase 7, Human | 660 | 0.23 | Binding ≤ 1μM |
| MMP9_HUMAN | P14780 | Matrix Metalloproteinase 9, Human | 5 | 0.31 | Binding ≤ 1μM |
| MMP1_HUMAN | P03956 | Matrix Metalloproteinase-1, Human | 21 | 0.28 | Binding ≤ 1μM |
| MMP2_HUMAN | P08253 | Matrix Metalloproteinase-2, Human | 7 | 0.30 | Binding ≤ 1μM |
| ADA17_HUMAN | P78536 | ADAM17, Human | 4 | 0.31 | Binding ≤ 10μM |
| MMP10_HUMAN | P09238 | Matrix Metalloproteinase 10, Human | 190 | 0.25 | Binding ≤ 10μM |
| MMP13_HUMAN | P45452 | Matrix Metalloproteinase 13, Human | 10 | 0.29 | Binding ≤ 10μM |
| MMP14_HUMAN | P50281 | Matrix Metalloproteinase 14, Human | 1200 | 0.22 | Binding ≤ 10μM |
| MMP7_HUMAN | P09237 | Matrix Metalloproteinase 7, Human | 660 | 0.23 | Binding ≤ 10μM |
| MMP9_HUMAN | P14780 | Matrix Metalloproteinase 9, Human | 5 | 0.31 | Binding ≤ 10μM |
| MMP1_HUMAN | P03956 | Matrix Metalloproteinase-1, Human | 21 | 0.28 | Binding ≤ 10μM |
| MMP2_HUMAN | P08253 | Matrix Metalloproteinase-2, Human | 7 | 0.30 | Binding ≤ 10μM |
| A4_HUMAN | P05067 | Beta Amyloid A4 Protein, Human | 200 | 0.25 | Functional ≤ 10μM |
| Z80088 | Z80088 | CHO (Ovarian Cells) | 200 | 0.25 | Functional ≤ 10μM |
| Z80936 | Z80936 | HEK293 (Embryonic Kidney Fibroblasts) | 500 | 0.23 | Functional ≤ 10μM |
| Description | Species |
|---|---|
| Activated NOTCH1 Transmits Signal to the Nucleus | |
| Activation of Matrix Metalloproteinases | |
| Advanced glycosylation endproduct receptor signaling | |
| Amyloids | |
| Assembly of collagen fibrils and other multimeric structures | |
| Basigin interactions | |
| Collagen degradation | |
| Constitutive Signaling by NOTCH1 HD Domain Mutants | |
| Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | |
| Constitutive Signaling by NOTCH1 PEST Domain Mutants | |
| Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant | |
| Degradation of the extracellular matrix | |
| DEx/H-box helicases activate type I IFN and inflammatory cytokines production | |
| ECM proteoglycans | |
| EPH-ephrin mediated repulsion of cells | |
| Formyl peptide receptors bind formyl peptides and many other ligands | |
| G alpha (i) signalling events | |
| G alpha (q) signalling events | |
| Growth hormone receptor signaling | |
| Nuclear signaling by ERBB4 | |
| Platelet degranulation | |
| Regulated proteolysis of p75NTR | |
| Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l | |
| Release of Hh-Np from the secreting cell | |
| RIP-mediated NFkB activation via ZBP1 | |
| Signaling by EGFR | |
| Signaling by SCF-KIT | |
| TAK1 activates NFkB by phosphorylation and activation of IKKs complex | |
| The NLRP3 inflammasome | |
| TNF signaling | |
| TRAF6 mediated NF-kB activation |
No pre-computed analogs available. Try a structural similarity search.