| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| September 29th, 2005 | 35 | Yes |
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 6.14 | 1.46 | -44.95 | 2 | 7 | 1 | 73 | 513.449 | 9 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| CSK-1-E | Tyrosine-protein Kinase CSK (cluster #1 Of 1), Eukaryotic | Eukaryotes | 9000 | 0.20 | Binding ≤ 10μM |
| EGFR-1-E | Epidermal Growth Factor Receptor ErbB1 (cluster #1 Of 4), Eukaryotic | Eukaryotes | 350 | 0.26 | Binding ≤ 10μM |
| FGFR1-1-E | Fibroblast Growth Factor Receptor 1 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 43 | 0.29 | Binding ≤ 10μM |
| FGFR2-1-E | Fibroblast Growth Factor Receptor 2 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 43 | 0.29 | Binding ≤ 10μM |
| FGFR3-1-E | Fibroblast Growth Factor Receptor 3 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 43 | 0.29 | Binding ≤ 10μM |
| FGFR4-1-E | Fibroblast Growth Factor Receptor 4 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 43 | 0.29 | Binding ≤ 10μM |
| PGFRA-1-E | Platelet-derived Growth Factor Receptor Alpha (cluster #1 Of 2), Eukaryotic | Eukaryotes | 96 | 0.28 | Binding ≤ 10μM |
| PGFRB-1-E | Platelet-derived Growth Factor Receptor Beta (cluster #1 Of 1), Eukaryotic | Eukaryotes | 7 | 0.33 | Binding ≤ 10μM |
| SRC-1-E | Tyrosine-protein Kinase SRC (cluster #1 Of 3), Eukaryotic | Eukaryotes | 9000 | 0.20 | Binding ≤ 10μM |
| WEE1-1-E | Serine/threonine-protein Kinase WEE1 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 165 | 0.27 | Binding ≤ 10μM |
| PGFRA-1-E | Platelet-derived Growth Factor Receptor Alpha (cluster #1 Of 1), Eukaryotic | Eukaryotes | 2 | 0.35 | Functional ≤ 10μM |
| PGFRB-1-E | Platelet-derived Growth Factor Receptor Beta (cluster #1 Of 1), Eukaryotic | Eukaryotes | 5 | 0.33 | Functional ≤ 10μM |
| Z80152-1-O | HCT-8 (Ileocecal Adenocarcinoma) (cluster #1 Of 2), Other | Other | 420 | 0.26 | Functional ≤ 10μM |
| Z80166-1-O | HT-29 (Colon Adenocarcinoma Cells) (cluster #1 Of 12), Other | Other | 280 | 0.26 | Functional ≤ 10μM |
| Z80742-1-O | C6 (Glioma Cells) (cluster #1 Of 3), Other | Other | 5 | 0.33 | Functional ≤ 10μM |
| Z80951-1-O | NIH3T3 (Fibroblasts) (cluster #1 Of 4), Other | Other | 350 | 0.26 | Functional ≤ 10μM |
| Z81331-1-O | SW-620 (Colon Adenocarcinoma Cells) (cluster #1 Of 6), Other | Other | 270 | 0.26 | Functional ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| EGFR_HUMAN | P00533 | Epidermal Growth Factor Receptor ErbB1, Human | 350 | 0.26 | Binding ≤ 1μM |
| FGFR1_MOUSE | P16092 | Fibroblast Growth Factor Receptor 1, Mouse | 43 | 0.29 | Binding ≤ 1μM |
| FGFR1_HUMAN | P11362 | Fibroblast Growth Factor Receptor 1, Human | 43 | 0.29 | Binding ≤ 1μM |
| FGFR2_MOUSE | P21803 | Fibroblast Growth Factor Receptor 2, Mouse | 43 | 0.29 | Binding ≤ 1μM |
| FGFR2_HUMAN | P21802 | Fibroblast Growth Factor Receptor 2, Human | 44 | 0.29 | Binding ≤ 1μM |
| FGFR3_HUMAN | P22607 | Fibroblast Growth Factor Receptor 3, Human | 44 | 0.29 | Binding ≤ 1μM |
| FGFR3_MOUSE | Q61851 | Fibroblast Growth Factor Receptor 3, Mouse | 43 | 0.29 | Binding ≤ 1μM |
| FGFR4_HUMAN | P22455 | Fibroblast Growth Factor Receptor 4, Human | 44 | 0.29 | Binding ≤ 1μM |
| FGFR4_MOUSE | Q03142 | Fibroblast Growth Factor Receptor 4, Mouse | 43 | 0.29 | Binding ≤ 1μM |
| PGFRA_RAT | P20786 | Platelet-derived Growth Factor Receptor Alpha, Rat | 5 | 0.33 | Binding ≤ 1μM |
| PGFRA_MOUSE | P26618 | Platelet-derived Growth Factor Receptor Alpha, Mouse | 79 | 0.28 | Binding ≤ 1μM |
| PGFRB_RAT | Q05030 | Platelet-derived Growth Factor Receptor Beta, Rat | 5 | 0.33 | Binding ≤ 1μM |
| PGFRB_MOUSE | P05622 | Platelet-derived Growth Factor Receptor Beta, Mouse | 79 | 0.28 | Binding ≤ 1μM |
| WEE1_HUMAN | P30291 | Serine/threonine-protein Kinase WEE1, Human | 165 | 0.27 | Binding ≤ 1μM |
| CSK_MOUSE | P41241 | Tyrosine-protein Kinase CSK, Mouse | 7 | 0.33 | Binding ≤ 1μM |
| SRC_CHICK | P00523 | Tyrosine-protein Kinase SRC, Chick | 9 | 0.32 | Binding ≤ 1μM |
| SRC_HUMAN | P12931 | Tyrosine-protein Kinase SRC, Human | 7 | 0.33 | Binding ≤ 1μM |
| SRC_MOUSE | P05480 | Tyrosine-protein Kinase SRC, Mouse | 9 | 0.32 | Binding ≤ 1μM |
| EGFR_HUMAN | P00533 | Epidermal Growth Factor Receptor ErbB1, Human | 350 | 0.26 | Binding ≤ 10μM |
| FGFR1_MOUSE | P16092 | Fibroblast Growth Factor Receptor 1, Mouse | 43 | 0.29 | Binding ≤ 10μM |
| FGFR1_HUMAN | P11362 | Fibroblast Growth Factor Receptor 1, Human | 43 | 0.29 | Binding ≤ 10μM |
| FGFR2_HUMAN | P21802 | Fibroblast Growth Factor Receptor 2, Human | 44 | 0.29 | Binding ≤ 10μM |
| FGFR2_MOUSE | P21803 | Fibroblast Growth Factor Receptor 2, Mouse | 43 | 0.29 | Binding ≤ 10μM |
| FGFR3_MOUSE | Q61851 | Fibroblast Growth Factor Receptor 3, Mouse | 43 | 0.29 | Binding ≤ 10μM |
| FGFR3_HUMAN | P22607 | Fibroblast Growth Factor Receptor 3, Human | 44 | 0.29 | Binding ≤ 10μM |
| FGFR4_MOUSE | Q03142 | Fibroblast Growth Factor Receptor 4, Mouse | 43 | 0.29 | Binding ≤ 10μM |
| FGFR4_HUMAN | P22455 | Fibroblast Growth Factor Receptor 4, Human | 44 | 0.29 | Binding ≤ 10μM |
| PGFRA_RAT | P20786 | Platelet-derived Growth Factor Receptor Alpha, Rat | 5 | 0.33 | Binding ≤ 10μM |
| PGFRA_MOUSE | P26618 | Platelet-derived Growth Factor Receptor Alpha, Mouse | 79 | 0.28 | Binding ≤ 10μM |
| PGFRB_RAT | Q05030 | Platelet-derived Growth Factor Receptor Beta, Rat | 5 | 0.33 | Binding ≤ 10μM |
| PGFRB_MOUSE | P05622 | Platelet-derived Growth Factor Receptor Beta, Mouse | 79 | 0.28 | Binding ≤ 10μM |
| WEE1_HUMAN | P30291 | Serine/threonine-protein Kinase WEE1, Human | 165 | 0.27 | Binding ≤ 10μM |
| CSK_MOUSE | P41241 | Tyrosine-protein Kinase CSK, Mouse | 7 | 0.33 | Binding ≤ 10μM |
| SRC_HUMAN | P12931 | Tyrosine-protein Kinase SRC, Human | 7 | 0.33 | Binding ≤ 10μM |
| SRC_MOUSE | P05480 | Tyrosine-protein Kinase SRC, Mouse | 9 | 0.32 | Binding ≤ 10μM |
| SRC_CHICK | P00523 | Tyrosine-protein Kinase SRC, Chick | 9 | 0.32 | Binding ≤ 10μM |
| Z80742 | Z80742 | C6 (Glioma Cells) | 120 | 0.28 | Functional ≤ 10μM |
| Z80152 | Z80152 | HCT-8 (Ileocecal Adenocarcinoma) | 420 | 0.26 | Functional ≤ 10μM |
| Z80166 | Z80166 | HT-29 (Colon Adenocarcinoma Cells) | 280 | 0.26 | Functional ≤ 10μM |
| Z80951 | Z80951 | NIH3T3 (Fibroblasts) | 1.1 | 0.36 | Functional ≤ 10μM |
| PGFRA_MOUSE | P26618 | Platelet-derived Growth Factor Receptor Alpha, Mouse | 1.8 | 0.35 | Functional ≤ 10μM |
| PGFRA_RAT | P20786 | Platelet-derived Growth Factor Receptor Alpha, Rat | 5 | 0.33 | Functional ≤ 10μM |
| PGFRB_RAT | Q05030 | Platelet-derived Growth Factor Receptor Beta, Rat | 5 | 0.33 | Functional ≤ 10μM |
| PGFRB_MOUSE | P05622 | Platelet-derived Growth Factor Receptor Beta, Mouse | 1.8 | 0.35 | Functional ≤ 10μM |
| Z81331 | Z81331 | SW-620 (Colon Adenocarcinoma Cells) | 270 | 0.26 | Functional ≤ 10μM |
| Description | Species |
|---|---|
| Activated point mutants of FGFR2 | |
| ADP signalling through P2Y purinoceptor 1 | |
| betaKlotho-mediated ligand binding | |
| c-src mediated regulation of Cx43 function and closure of gap junctions | |
| CD28 co-stimulation | |
| Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | |
| Constitutive PI3K/AKT Signaling in Cancer | |
| CTLA4 inhibitory signaling | |
| Cyclin A/B1 associated events during G2/M transition | |
| Cyclin A:Cdk2-associated events at S phase entry | |
| Cyclin E associated events during G1/S transition | |
| DCC mediated attractive signaling | |
| Downstream signal transduction | |
| DSCAM interactions | |
| EGFR downregulation | |
| EGFR interacts with phospholipase C-gamma | |
| EGFR Transactivation by Gastrin | |
| EPH-ephrin mediated repulsion of cells | |
| EPH-Ephrin signaling | |
| EPHA-mediated growth cone collapse | |
| EPHB-mediated forward signaling | |
| Ephrin signaling | |
| Factors involved in megakaryocyte development and platelet production | |
| FCGR activation | |
| FGFR1c and Klotho ligand binding and activation | |
| FGFR1c ligand binding and activation | |
| FGFR4 ligand binding and activation | |
| FRS2-mediated cascade | |
| G2/M DNA replication checkpoint | |
| GAB1 signalosome | |
| GP1b-IX-V activation signalling | |
| GRB2 events in EGFR signaling | |
| GRB2 events in ERBB2 signaling | |
| GRB2:SOS provides linkage to MAPK signaling for Integrins | |
| Integrin alphaIIb beta3 signaling | |
| NCAM signaling for neurite out-growth | |
| Negative regulation of FGFR signaling | |
| Netrin mediated repulsion signals | |
| p130Cas linkage to MAPK signaling for integrins | |
| p38MAPK events | |
| PD-1 signaling | |
| Phospholipase C-mediated cascade | |
| Phosphorylation of CD3 and TCR zeta chains | |
| PI-3K cascade | |
| PI3K Cascade | |
| PI3K events in ERBB2 signaling | |
| PIP3 activates AKT signaling | |
| PLCG1 events in ERBB2 signaling | |
| Polo-like kinase mediated events | |
| Recycling pathway of L1 | |
| Regulation of KIT signaling | |
| SHC-mediated cascade | |
| SHC1 events in EGFR signaling | |
| SHC1 events in ERBB2 signaling | |
| Signal regulatory protein (SIRP) family interactions | |
| Signal transduction by L1 | |
| Signaling by activated point mutants of FGFR1 | |
| Signaling by activated point mutants of FGFR3 | |
| Signaling by constitutively active EGFR | |
| Signaling by EGFR | |
| Signaling by ERBB2 | |
| Signaling by ERBB4 | |
| Signaling by FGFR mutants | |
| Signaling by FGFR1 amplification mutants | |
| Signaling by FGFR2 amplification mutants | |
| Signaling by FGFR3 mutants | |
| Signaling by FGFR4 mutants | |
| Signaling by PDGF | |
| Signaling by SCF-KIT | |
| Spry regulation of FGF signaling | |
| t(4;14) translocations of FGFR3 | |
| Thrombin signalling through proteinase activated receptors (PARs) | |
| VEGFA-VEGFR2 Pathway | |
| VEGFR2 mediated cell proliferation |
No pre-computed analogs available. Try a structural similarity search.