UCSF

ZINC00002002

Substance Information

In ZINC since Heavy atoms Benign functionality
September 30th, 2005 21 Yes

Other Names:

1,2,3,6-Tetrahydro-1,3-dimethyl-2,6-dioxo-7H-purine-7-acetic acid,compound with N-(p-methoxybenzyl)-N',N'-dimethyl-N-(2-pyridyl)eth ane-1,2-diamine (1:1); 7H-Purine-7-acetic acid, 1,2,3,6-tetrahydro-1,3-dimethyl-2,6-dioxo-, compd. with N-((4-methoxyphenyl

1,2-Ethanediamine, N-((4-methoxyphenyl)methyl)-N',N'-dimethyl-N-2-pyridinyl-; 2-((2-(Dimethylamino)ethyl)-(p-methoxybenzyl)amino)pyridine; 2-((p-Methoxybenzyl)(2-(dimethylamino)ethyl)amino)pyridine; Afko-Hist; Anhistabs; Anhistol; Antalergan; Antallergan

2786 R.P. phosphate; LS-131456; N-alpha-Pyridyl-N-p-methoxybenzyl-N',N'-dimethylethylenediamine phosphate; N-p-Methoxybenzyl-N-dimethylaminoethyl alpha-aminopyridine; Neoantergan phosphate; Pyridine, 2-((2-(dimethylamino)ethyl)(p-methoxybenzyl)amino)-, ph

57383-74-1; D08184; Fluidasa (TN); Mepyramine theophyllineacetate

59-33-6; D05660; Pymafed (TN); Pyrilamine maleate (USP)

59-33-6; Prestwick_634; Pyrilamine maleate

91-84-9; C11798; Mepyramine; Pyrilamine

ANTAMINE

BAN); Pyrilamine Maleate (FDA

BRD-K97564742-050-04-6

DNC001175

INN); Pyrilamine Maleate (FDA

LS-194205

Mepyramine

Mepyramine (BAN

Mepyramine (INN

Mepyramine; N',N'-dimethyl-N-(p-methoxybenzyl)-N-(2-pyridyl)ethylenediamine; N-(p-methoxybenzyl)-N',N'-dimethyl-N-(alpha-pyridyl)ethylenediamine; N-[(4-methoxyphenyl)methyl]-N',N'-dimethyl-N-2-pyridinyl-1,2-ethanediamine; Pyrilamine; pyranisamine

MFCD00023451

MFCD00069333

N,N-Dimethyl-N'-(4-methoxybenzyl)-N'-(2-pyridyl)ethylenediamine

PYRILAMINE

Pyrilamine maleate salt

USP)

Download: MOL2 SDF SMILES Flexibase

Annotations

Vendors

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.63 10.25 -95.18 2 4 2 31 287.407 7
Hi High (pH 8-9.5) 2.63 7.51 -5.69 0 4 0 29 285.391 7

Vendor Notes

Note Type Comments Provided By
ALOGPS_SOLUBILITY 7.81e-01 g/l DrugBank-approved
therap antihistaminic MicroSource Spectrum
Patent Database Links EP1772767; EP1815846; EP1829527; EP1829528; US2003236298; US2005070525; US2005113383; US2006166960; WO2008137609 ChEBI
Therapy H1 Histamine receptor antagonist SMDC Iconix

Activity (Go SEA)

Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
AA3R-3-E Adenosine Receptor A3 (cluster #3 Of 6), Eukaryotic Eukaryotes 1 0.60 Binding ≤ 10μM
HRH1-1-E Histamine H1 Receptor (cluster #1 Of 2), Eukaryotic Eukaryotes 6 0.55 Binding ≤ 10μM
KCNH2-5-E HERG (cluster #5 Of 5), Eukaryotic Eukaryotes 1100 0.40 Binding ≤ 10μM
HRH1-1-E Histamine H1 Receptor (cluster #1 Of 2), Eukaryotic Eukaryotes 10 0.53 Functional ≤ 10μM
Z50425-3-O Plasmodium Falciparum (cluster #3 Of 22), Other Other 7943 0.34 Functional ≤ 10μM
Z50512-1-O Cavia Porcellus (cluster #1 Of 7), Other Other 17 0.52 Functional ≤ 10μM
Z50597-1-O Rattus Norvegicus (cluster #1 Of 12), Other Other 9976 0.33 Functional ≤ 10μM
ChEMBL Target Annotations
Uniprot Swissprot Description Affinity (nM) LE (kcal/mol/atom) Type
AA3R_HUMAN P33765 Adenosine A3 Receptor, Human 1.3 0.59 Binding ≤ 1μM
HRH1_HUMAN P35367 Histamine H1 Receptor, Human 1.8 0.58 Binding ≤ 1μM
HRH1_CAVPO P31389 Histamine H1 Receptor, Guinea Pig 1.5 0.59 Binding ≤ 1μM
AA3R_HUMAN P33765 Adenosine A3 Receptor, Human 1.3 0.59 Binding ≤ 10μM
KCNH2_HUMAN Q12809 HERG, Human 1100 0.40 Binding ≤ 10μM
HRH1_CAVPO P31389 Histamine H1 Receptor, Guinea Pig 1.5 0.59 Binding ≤ 10μM
HRH1_HUMAN P35367 Histamine H1 Receptor, Human 1.8 0.58 Binding ≤ 10μM
Z50512 Z50512 Cavia Porcellus 17 0.52 Functional ≤ 10μM
HRH1_HUMAN P35367 Histamine H1 Receptor, Human 10 0.53 Functional ≤ 10μM
HRH1_CAVPO P31389 Histamine H1 Receptor, Guinea Pig 34 0.50 Functional ≤ 10μM
Z50425 Z50425 Plasmodium Falciparum 5011.87234 0.35 Functional ≤ 10μM
Z50597 Z50597 Rattus Norvegicus 1032 0.40 Functional ≤ 10μM

Reactome Annotations from Targets (via Uniprot)

Description Species
Adenosine P1 receptors
G alpha (i) signalling events
G alpha (q) signalling events
Histamine receptors
Voltage gated Potassium channels

Analogs ( Draw Identity 99% 90% 80% 70% )