| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| September 30th, 2005 | 18 | Yes |
Popular Name: Pindolol Pindolol
Find On: PubMed — Wikipedia — Google
CAS Numbers: 13523-86-9 , [13523-86-9]
(1)-1-(1H-Indol-4-yloxy)-3-(isopropylamino)propan-2-ol
1-((1-Methylethyl)amino)-3-(4-indolyloxy)-2-propanol
1-(1H-Indol-4-yloxy)-3-((1-methylethyl)amino)-2-propanol
1-(1H-Indol-4-yloxy)-3-(isopropylamino)-2-propanol
1-(1H-indol-4-yloxy)-3-(isopropylamino)propan-2-ol
1-(1H-indol-4-yloxy)-3-(propan-2-ylamino)-propan-2-ol
1-(1H-indol-4-yloxy)-3-(propan-2-ylamino)propan-2-ol
1-(1H-Indol-4-yloxy)-3-isopropylamino-propan-2-ol
1-(1H-Indol-4-yloxy)-3-[(1-methylethyl)amino]-2-propanol
1-(1H-indol-4-yloxy)-3-[(1-methylethyl)amino]propan-2-ol
1-(1H-indol-4-yloxy)-3-[(propan-2-yl)amino]propan-2-ol
1-(Indol-4-yloxy)-3-(isopropylamino)-2-propanol
1-[1H-INDOL-4-YLOXY]-3-[ISOPROPYLAMINO]-2-PROPANOL
13523-86-9; Blocklin-L (TN); Carvisken (TN); D00513; Pindolol (JP16/USP/INN); Visken (TN)
13523-86-9; Pindolol; Prestwick_397
2-Propanol, 1-(1H-indol-4-yloxy)-3-((1-methylethyl)amino)-
2-Propanol, 1-(1H-indol-4-yloxy)-3-(1-methylethyl)amino-
2-Propanol, 1-(1H-indol-4-yloxy)-3-[(1-methylethyl)amino]-
2-Propanol, 1-(4-indolyloxy)-3-(isopropylamino)-
2-Propanol, 1-(indol-4-yloxy)-3-(isopropylamino)-, (+-)-
4-(2-Hydroxy-3-isopropylaminopropoxy)-indole
4-(3-(Isopropylamino)-2-hydroxypropoxy)indole
5-21-03-00017 (Beilstein Handbook Reference)
C14H20N2O2.C7H8ClN3O4S2; HYDROCHLOROTHIAZIDE; PINDOLOL; LS-178465; VISKAZIDE
CPD000059120; PINDOLOL; SAM002264631
CPD000059120; PINDOLOL; SAM002264631; Terazosin
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 1.98 | 3.18 | -42.7 | 4 | 4 | 1 | 62 | 249.334 | 6 | ↓ |
| Hi High (pH 8-9.5) | 1.98 | 1.9 | -9.07 | 3 | 4 | 0 | 57 | 248.326 | 6 | ↓ |
| Note Type | Comments | Provided By |
|---|---|---|
| mechanism | . | ZereneX Building Blocks |
| mechanism | 5HT1A serotonin receptor antagonist | IBScreen Bioactives |
| mechanism | 5HT1A serotonin receptor antagonist | IBScreen Bioactives |
| ALOGPS_SOLUBILITY | 8.61e-01 g/l | DrugBank-approved |
| UniProt Database Links | ADA2A_HUMAN; ADA2B_HUMAN; OAR1_LYMST; OAR2_LYMST | ChEBI |
| therap | antihypertensive, antianginal, antiarrhythmic, antiglaucoma | MicroSource Spectrum |
| Patent Database Links | EP1479666; EP1533292; EP1553091; EP1555019; EP1602334; EP1629835; EP1669345; EP1681051; EP1746099; EP1790353; EP1815846; EP1829527; EP1829528; EP1829858; EP1862181; EP1884513; EP1889847; EP1990049; US2002082300; US2002115655; US2004147575; US2005059810; U | ChEBI |
| PUBCHEM_SUBSTANCE_COMMENT | NCC_SAMPLE_SUPPLIER : LightBiologicals; NCC_SUPPLIER_STRUCTURE_ID : P-1003 | NIH Clinical Collection via PubChem |
| mechanism | Non-cardioselective beta-Adrenoceptor antagonist | IBScreen Bioactives IBScreen Bioactives |
| Therapy | Nonselective beta adrenoceptor antagonist; vasodilator | SMDC Iconix |
| mechanism | Partial agonist | IBScreen Bioactives |
| mechanism | Possesses intrinsic sympathomimetic actions (ISA), but little membrane-stabilizing activity | IBScreen Bioactives |
| PUBCHEM_SUBSTANCE_COMMENT | SAMPLE_SUPPLIER: LightBiologicals; SUPPLIER_STRUCTURE_ID: P-1003 | NIH Clinical Collection via PubChem |
| mechanism | Sympatholytic-Beta | IBScreen Bioactives |
| PUBCHEM_PATENT_ID | US4294851; WO1999002159A1; WO1999058130A1 | IBM Patent Data |
| biological_use | Used in treatment of Angina pectoris and hypertension | IBScreen Bioactives |
| biological_use | Vasodilator | IBScreen Bioactives IBScreen Bioactives |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| 5HT1A-3-E | Serotonin 1a (5-HT1a) Receptor (cluster #3 Of 4), Eukaryotic | Eukaryotes | 20 | 0.60 | Binding ≤ 10μM |
| 5HT1B-1-E | Serotonin 1b (5-HT1b) Receptor (cluster #1 Of 2), Eukaryotic | Eukaryotes | 80 | 0.55 | Binding ≤ 10μM |
| 5HT1D-1-E | Serotonin 1d (5-HT1d) Receptor (cluster #1 Of 2), Eukaryotic | Eukaryotes | 100 | 0.54 | Binding ≤ 10μM |
| 5HT1F-2-E | Serotonin 1f (5-HT1f) Receptor (cluster #2 Of 2), Eukaryotic | Eukaryotes | 100 | 0.54 | Binding ≤ 10μM |
| ADRB1-2-E | Beta-1 Adrenergic Receptor (cluster #2 Of 2), Eukaryotic | Eukaryotes | 1 | 0.70 | Binding ≤ 10μM |
| ADRB2-1-E | Beta-2 Adrenergic Receptor (cluster #1 Of 2), Eukaryotic | Eukaryotes | 1 | 0.70 | Binding ≤ 10μM |
| ADRB3-2-E | Beta-3 Adrenergic Receptor (cluster #2 Of 2), Eukaryotic | Eukaryotes | 1 | 0.70 | Binding ≤ 10μM |
| 5HT1B-2-E | Serotonin 1b (5-HT1b) Receptor (cluster #2 Of 2), Eukaryotic | Eukaryotes | 2600 | 0.43 | Functional ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| ADRB1_RAT | P18090 | Beta-1 Adrenergic Receptor, Rat | 1 | 0.70 | Binding ≤ 1μM |
| ADRB1_HUMAN | P08588 | Beta-1 Adrenergic Receptor, Human | 0.52 | 0.72 | Binding ≤ 1μM |
| ADRB2_HUMAN | P07550 | Beta-2 Adrenergic Receptor, Human | 0.4 | 0.73 | Binding ≤ 1μM |
| ADRB3_RAT | P26255 | Beta-3 Adrenergic Receptor, Rat | 1 | 0.70 | Binding ≤ 1μM |
| 5HT1A_RAT | P19327 | Serotonin 1a (5-HT1a) Receptor, Rat | 100 | 0.54 | Binding ≤ 1μM |
| 5HT1A_HUMAN | P08908 | Serotonin 1a (5-HT1a) Receptor, Human | 110 | 0.54 | Binding ≤ 1μM |
| 5HT1B_RAT | P28564 | Serotonin 1b (5-HT1b) Receptor, Rat | 100 | 0.54 | Binding ≤ 1μM |
| 5HT1D_RAT | P28565 | Serotonin 1d (5-HT1d) Receptor, Rat | 100 | 0.54 | Binding ≤ 1μM |
| 5HT1F_RAT | P30940 | Serotonin 1f (5-HT1f) Receptor, Rat | 100 | 0.54 | Binding ≤ 1μM |
| ADRB1_RAT | P18090 | Beta-1 Adrenergic Receptor, Rat | 1 | 0.70 | Binding ≤ 10μM |
| ADRB1_HUMAN | P08588 | Beta-1 Adrenergic Receptor, Human | 0.52 | 0.72 | Binding ≤ 10μM |
| ADRB2_HUMAN | P07550 | Beta-2 Adrenergic Receptor, Human | 0.4 | 0.73 | Binding ≤ 10μM |
| ADRB3_RAT | P26255 | Beta-3 Adrenergic Receptor, Rat | 1 | 0.70 | Binding ≤ 10μM |
| 5HT1A_RAT | P19327 | Serotonin 1a (5-HT1a) Receptor, Rat | 100 | 0.54 | Binding ≤ 10μM |
| 5HT1A_HUMAN | P08908 | Serotonin 1a (5-HT1a) Receptor, Human | 110 | 0.54 | Binding ≤ 10μM |
| 5HT1B_RAT | P28564 | Serotonin 1b (5-HT1b) Receptor, Rat | 100 | 0.54 | Binding ≤ 10μM |
| 5HT1D_RAT | P28565 | Serotonin 1d (5-HT1d) Receptor, Rat | 100 | 0.54 | Binding ≤ 10μM |
| 5HT1F_RAT | P30940 | Serotonin 1f (5-HT1f) Receptor, Rat | 100 | 0.54 | Binding ≤ 10μM |
| 5HT1B_HUMAN | P28222 | Serotonin 1b (5-HT1b) Receptor, Human | 2600 | 0.43 | Functional ≤ 10μM |
| Description | Species |
|---|---|
| Adrenoceptors | |
| G alpha (i) signalling events | |
| G alpha (s) signalling events | |
| Serotonin receptors |
