ZINC 12

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	4.92	13.91	-78.14	3	6	2	50	504.988	5	↓ MOL2 SDF SMILES Flexibase
Hi High (pH 8-9.5)	4.92	11.11	-8.96	1	6	0	48	502.972	5	↓ MOL2 SDF SMILES Flexibase
Mid Mid (pH 6-8)	4.92	11.57	-35.34	2	6	1	49	503.98	5	↓ MOL2 SDF SMILES Flexibase

43176689

Analogs

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Chembo Pharma
- KB-78393

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Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
ALK-1-E	ALK Tyrosine Kinase Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	15	0.29	Binding ≤ 10μM

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	4.20	14.61	-88.56	3	6	2	54	519.64	6	↓ MOL2 SDF SMILES Flexibase
Mid Mid (pH 6-8)	4.20	14.16	-47.88	2	6	1	53	518.632	6	↓ MOL2 SDF SMILES Flexibase

2273180

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Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
ALK-1-E	ALK Tyrosine Kinase Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	2100	0.32	Binding ≤ 10μM
RET-1-E	Tyrosine-protein Kinase Receptor RET (cluster #1 Of 1), Eukaryotic	Eukaryotes	1600	0.32	Binding ≤ 10μM
Z100502-1-O	ARO (Anaplastic Thyroid Carcinoma Cells) (cluster #1 Of 1), Other	Other	8500	0.28	Functional ≤ 10μM

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	5.84	0.98	-7.41	0	2	0	36	362.523	4	↓ MOL2 SDF SMILES Flexibase
Lo Low (pH 4.5-6)	5.84	1.1	-35.03	1	2	1	37	363.531	4	↓ MOL2 SDF SMILES Flexibase

2259037

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Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
ALK-1-E	ALK Tyrosine Kinase Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	4000	0.29	Binding ≤ 10μM
RET-1-E	Tyrosine-protein Kinase Receptor RET (cluster #1 Of 1), Eukaryotic	Eukaryotes	4800	0.29	Binding ≤ 10μM

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	6.00	1.72	-7.85	0	2	0	36	380.513	4	↓ MOL2 SDF SMILES Flexibase

1649340

Analogs

602192

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Popular Name: (R)-Roscovitine (R)-Roscovitine

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Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
ALK-1-E	ALK Tyrosine Kinase Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	2300	0.30	Binding ≤ 10μM
CCNA1-1-E	Cyclin A1 (cluster #1 Of 3), Eukaryotic	Eukaryotes	700	0.33	Binding ≤ 10μM
CCNA2-1-E	Cyclin A2 (cluster #1 Of 3), Eukaryotic	Eukaryotes	700	0.33	Binding ≤ 10μM
CCNB1-1-E	G2/mitotic-specific Cyclin B1 (cluster #1 Of 2), Eukaryotic	Eukaryotes	650	0.33	Binding ≤ 10μM
CCNB2-1-E	G2/mitotic-specific Cyclin B2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	650	0.33	Binding ≤ 10μM
CCNB3-1-E	G2/mitotic-specific Cyclin B3 (cluster #1 Of 2), Eukaryotic	Eukaryotes	650	0.33	Binding ≤ 10μM
CCNE1-1-E	G1/S-specific Cyclin E1 (cluster #1 Of 2), Eukaryotic	Eukaryotes	700	0.33	Binding ≤ 10μM
CCNE2-1-E	G1/S-specific Cyclin E2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	700	0.33	Binding ≤ 10μM
CCNH-1-E	Cyclin H (cluster #1 Of 1), Eukaryotic	Eukaryotes	540	0.34	Binding ≤ 10μM
CCNT1-1-E	Cyclin T1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	950	0.32	Binding ≤ 10μM
CCNT2-1-E	Cyclin-T2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	810	0.33	Binding ≤ 10μM
CDK1-1-E	Cyclin-dependent Kinase 1 (cluster #1 Of 4), Eukaryotic	Eukaryotes	650	0.33	Binding ≤ 10μM
CDK1-1-E	Cyclin-dependent Kinase 1 (cluster #1 Of 4), Eukaryotic	Eukaryotes	650	0.33	Binding ≤ 10μM
CDK16-1-E	Serine/threonine-protein Kinase PCTAIRE-1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	990	0.32	Binding ≤ 10μM
CDK2-1-E	Cyclin-dependent Kinase 2 (cluster #1 Of 5), Eukaryotic	Eukaryotes	700	0.33	Binding ≤ 10μM
CDK4-2-E	Cyclin-dependent Kinase 4 (cluster #2 Of 3), Eukaryotic	Eukaryotes	100	0.38	Binding ≤ 10μM
CDK5-1-E	Cyclin-dependent Kinase 5 (cluster #1 Of 1), Eukaryotic	Eukaryotes	160	0.37	Binding ≤ 10μM
CDK5-1-E	Cyclin-dependent Kinase 5 (cluster #1 Of 1), Eukaryotic	Eukaryotes	270	0.35	Binding ≤ 10μM
CDK7-1-E	Cyclin-dependent Kinase 7 (cluster #1 Of 1), Eukaryotic	Eukaryotes	800	0.33	Binding ≤ 10μM
CDK9-1-E	Cyclin-dependent Kinase 9 (cluster #1 Of 2), Eukaryotic	Eukaryotes	950	0.32	Binding ≤ 10μM
CLK1-2-E	Dual Specificty Protein Kinase CLK1 (cluster #2 Of 2), Eukaryotic	Eukaryotes	2100	0.31	Binding ≤ 10μM
CLK2-1-E	Dual Specificity Protein Kinase CLK2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	700	0.33	Binding ≤ 10μM
CLK4-1-E	Dual Specificity Protein Kinase CLK4 (cluster #1 Of 2), Eukaryotic	Eukaryotes	4500	0.29	Binding ≤ 10μM
DYR1A-3-E	Dual Specificity Tyrosine-phosphorylation-regulated Kinase 1A (cluster #3 Of 3), Eukaryotic	Eukaryotes	5000	0.29	Binding ≤ 10μM
DYR1B-1-E	Dual Specificity Tyrosine-phosphorylation-regulated Kinase 1B (cluster #1 Of 1), Eukaryotic	Eukaryotes	1100	0.32	Binding ≤ 10μM
KC1D-1-E	Casein Kinase I Delta (cluster #1 Of 1), Eukaryotic	Eukaryotes	260	0.35	Binding ≤ 10μM
KC1E-1-E	Casein Kinase I Epsilon (cluster #1 Of 2), Eukaryotic	Eukaryotes	320	0.35	Binding ≤ 10μM
KC1G1-1-E	Casein Kinase I Gamma 1 (cluster #1 Of 2), Eukaryotic	Eukaryotes	3300	0.30	Binding ≤ 10μM
KC1G2-1-E	Casein Kinase I Gamma 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1400	0.32	Binding ≤ 10μM
KC1G3-1-E	Casein Kinase I Isoform Gamma-3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	2900	0.30	Binding ≤ 10μM
KS6A2-1-E	Ribosomal Protein S6 Kinase Alpha 2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	3200	0.30	Binding ≤ 10μM
MAT1-1-E	CDK-activating Kinase Assembly Factor MAT1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	540	0.34	Binding ≤ 10μM
PAK4-1-E	Serine/threonine-protein Kinase PAK 4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	6900	0.28	Binding ≤ 10μM
TTK-1-E	Dual Specificity Protein Kinase TTK (cluster #1 Of 2), Eukaryotic	Eukaryotes	2100	0.31	Binding ≤ 10μM
Z104294-1-O	Cyclin-dependent Kinase 5/CDK5 Activator 1 (cluster #1 Of 2), Other	Other	280	0.35	Binding ≤ 10μM
Z104294-1-O	Cyclin-dependent Kinase 5/CDK5 Activator 1 (cluster #1 Of 2), Other	Other	940	0.32	Binding ≤ 10μM
Z104296-2-O	Cyclin-dependent Kinase 1/cyclin B1 (cluster #2 Of 2), Other	Other	450	0.34	Binding ≤ 10μM
Z104299-1-O	Cyclin-dependent Kinase 2/cyclin E1 (cluster #1 Of 1), Other	Other	220	0.36	Binding ≤ 10μM
Z50425-15-O	Plasmodium Falciparum (cluster #15 Of 22), Other	Other	6310	0.28	Functional ≤ 10μM
Z80054-1-O	Caco-2 (Colon Adenocarcinoma Cells) (cluster #1 Of 4), Other	Other	6000	0.28	Functional ≤ 10μM
Z80390-10-O	PC-3 (Prostate Carcinoma Cells) (cluster #10 Of 10), Other	Other	8000	0.27	Functional ≤ 10μM
Z80928-3-O	HCT-116 (Colon Carcinoma Cells) (cluster #3 Of 9), Other	Other	5000	0.29	Functional ≤ 10μM

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	3.65	9.65	-10.26	3	7	0	88	354.458	8	↓ MOL2 SDF SMILES Flexibase
Lo Low (pH 4.5-6)	3.65	9.9	-28.83	4	7	1	89	355.466	8	↓ MOL2 SDF SMILES Flexibase
Lo Low (pH 4.5-6)	3.65	9.47	-25.05	4	7	1	89	355.466	8	↓ MOL2 SDF SMILES Flexibase

18128769

Analogs

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Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
ALK-1-E	ALK Tyrosine Kinase Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	4	0.47	Binding ≤ 10μM

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	5.02	6.77	-13.02	3	5	0	78	329.359	3	↓ MOL2 SDF SMILES Flexibase

3814434

Analogs

4095791
12501465

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Popular Name: staurosporine staurosporine

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Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
AAK1-1-E	Adaptor-associated Kinase (cluster #1 Of 2), Eukaryotic	Eukaryotes	1	0.36	Binding ≤ 10μM
AAPK1-1-E	AMP-activated Protein Kinase, Alpha-1 Subunit (cluster #1 Of 1), Eukaryotic	Eukaryotes	9	0.32	Binding ≤ 10μM
AAPK2-1-E	AMP-activated Protein Kinase, Alpha-2 Subunit (cluster #1 Of 1), Eukaryotic	Eukaryotes	12	0.32	Binding ≤ 10μM
ABL1-1-E	Tyrosine-protein Kinase ABL (cluster #1 Of 1), Eukaryotic	Eukaryotes	91	0.28	Binding ≤ 10μM
ABL2-1-E	Tyrosine-protein Kinase ABL2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	160	0.27	Binding ≤ 10μM
ACK1-1-E	Tyrosine Kinase Non-receptor Protein 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	17	0.31	Binding ≤ 10μM
ACV1B-1-E	Activin Receptor Type-1B (cluster #1 Of 1), Eukaryotic	Eukaryotes	680	0.25	Binding ≤ 10μM
ACVR1-1-E	Activin Receptor Type-1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	470	0.25	Binding ≤ 10μM
AKT1-2-E	RAC-alpha Serine/threonine-protein Kinase (cluster #2 Of 3), Eukaryotic	Eukaryotes	6	0.33	Binding ≤ 10μM
AKT2-2-E	Serine/threonine-protein Kinase AKT2 (cluster #2 Of 2), Eukaryotic	Eukaryotes	9	0.32	Binding ≤ 10μM
AKT3-2-E	Serine/threonine-protein Kinase AKT3 (cluster #2 Of 2), Eukaryotic	Eukaryotes	5	0.33	Binding ≤ 10μM
ALK-1-E	ALK Tyrosine Kinase Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	32	0.30	Binding ≤ 10μM
ANKK1-1-E	Ankyrin Repeat And Protein Kinase Domain-containing Protein 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	270	0.26	Binding ≤ 10μM
AURKA-1-E	Serine/threonine-protein Kinase Aurora-A (cluster #1 Of 3), Eukaryotic	Eukaryotes	22	0.31	Binding ≤ 10μM
AURKB-1-E	Serine/threonine-protein Kinase Aurora-B (cluster #1 Of 2), Eukaryotic	Eukaryotes	19	0.31	Binding ≤ 10μM
AURKC-1-E	Serine/threonine-protein Kinase Aurora-C (cluster #1 Of 2), Eukaryotic	Eukaryotes	23	0.31	Binding ≤ 10μM
AVR2B-1-E	Activin Receptor Type-2B (cluster #1 Of 1), Eukaryotic	Eukaryotes	4600	0.21	Binding ≤ 10μM
BLK-1-E	Tyrosine-protein Kinase BLK (cluster #1 Of 1), Eukaryotic	Eukaryotes	15	0.31	Binding ≤ 10μM
BMP2K-1-E	BMP-2-inducible Protein Kinase (cluster #1 Of 2), Eukaryotic	Eukaryotes	6	0.33	Binding ≤ 10μM
BMR1A-1-E	Bone Morphogenetic Protein Receptor Type-1A (cluster #1 Of 1), Eukaryotic	Eukaryotes	3700	0.22	Binding ≤ 10μM
BMX-1-E	Tyrosine-protein Kinase BMX (cluster #1 Of 1), Eukaryotic	Eukaryotes	410	0.26	Binding ≤ 10μM
BRSK1-1-E	BR Serine/threonine-protein Kinase 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	26	0.30	Binding ≤ 10μM
BRSK2-1-E	BR Serine/threonine-protein Kinase 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	4	0.34	Binding ≤ 10μM
BTK-1-E	Tyrosine-protein Kinase BTK (cluster #1 Of 1), Eukaryotic	Eukaryotes	710	0.25	Binding ≤ 10μM
CCNB1-1-E	G2/mitotic-specific Cyclin B1 (cluster #1 Of 2), Eukaryotic	Eukaryotes	6	0.33	Binding ≤ 10μM
CCNB2-1-E	G2/mitotic-specific Cyclin B2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	6	0.33	Binding ≤ 10μM
CCNB3-1-E	G2/mitotic-specific Cyclin B3 (cluster #1 Of 2), Eukaryotic	Eukaryotes	6	0.33	Binding ≤ 10μM
CCNE1-1-E	G1/S-specific Cyclin E1 (cluster #1 Of 2), Eukaryotic	Eukaryotes	20	0.31	Binding ≤ 10μM
CCNE2-1-E	G1/S-specific Cyclin E2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	20	0.31	Binding ≤ 10μM
CDK1-1-E	Cyclin-dependent Kinase 1 (cluster #1 Of 4), Eukaryotic	Eukaryotes	8	0.32	Binding ≤ 10μM
CDK14-1-E	Serine/threonine-protein Kinase PFTAIRE-1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	160	0.27	Binding ≤ 10μM
CDK16-1-E	Serine/threonine-protein Kinase PCTAIRE-1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	25	0.30	Binding ≤ 10μM
CDK17-1-E	Serine/threonine-protein Kinase PCTAIRE-2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	96	0.28	Binding ≤ 10μM
CDK18-1-E	Serine/threonine-protein Kinase PCTAIRE-3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	270	0.26	Binding ≤ 10μM
CDK19-1-E	Cell Division Cycle 2-like Protein Kinase 6 (cluster #1 Of 1), Eukaryotic	Eukaryotes	190	0.27	Binding ≤ 10μM
CDK2-1-E	Cyclin-dependent Kinase 2 (cluster #1 Of 5), Eukaryotic	Eukaryotes	8	0.32	Binding ≤ 10μM
CDK3-1-E	Cyclin-dependent Kinase 3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	7	0.33	Binding ≤ 10μM
CDK4-2-E	Cyclin-dependent Kinase 4 (cluster #2 Of 3), Eukaryotic	Eukaryotes	18	0.31	Binding ≤ 10μM
CDK5-1-E	Cyclin-dependent Kinase 5 (cluster #1 Of 1), Eukaryotic	Eukaryotes	89	0.28	Binding ≤ 10μM
CDK6-1-E	Cyclin-dependent Kinase 6 (cluster #1 Of 1), Eukaryotic	Eukaryotes	116	0.28	Binding ≤ 10μM
CDK7-1-E	Cyclin-dependent Kinase 7 (cluster #1 Of 1), Eukaryotic	Eukaryotes	45	0.29	Binding ≤ 10μM
CDK8-1-E	Cell Division Protein Kinase 8 (cluster #1 Of 1), Eukaryotic	Eukaryotes	510	0.25	Binding ≤ 10μM
CDK9-1-E	Cyclin-dependent Kinase 9 (cluster #1 Of 2), Eukaryotic	Eukaryotes	3	0.34	Binding ≤ 10μM
CHK1-1-E	Serine/threonine-protein Kinase Chk1 (cluster #1 Of 2), Eukaryotic	Eukaryotes	10	0.32	Binding ≤ 10μM
CHK2-1-E	Serine/threonine-protein Kinase Chk2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	7	0.33	Binding ≤ 10μM
CLK1-2-E	Dual Specificty Protein Kinase CLK1 (cluster #2 Of 2), Eukaryotic	Eukaryotes	32	0.30	Binding ≤ 10μM
CLK2-1-E	Dual Specificity Protein Kinase CLK2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	8	0.32	Binding ≤ 10μM
CLK3-1-E	Dual Specificity Protein Kinase CLK3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	910	0.24	Binding ≤ 10μM
CLK4-1-E	Dual Specificity Protein Kinase CLK4 (cluster #1 Of 2), Eukaryotic	Eukaryotes	10	0.32	Binding ≤ 10μM
CSF1R-1-E	Macrophage Colony-stimulating Factor 1 Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	12	0.32	Binding ≤ 10μM
CSK-1-E	Tyrosine-protein Kinase CSK (cluster #1 Of 1), Eukaryotic	Eukaryotes	440	0.25	Binding ≤ 10μM
CSK21-1-E	Casein Kinase II Alpha (cluster #1 Of 3), Eukaryotic	Eukaryotes	7620	0.20	Binding ≤ 10μM
CSK22-1-E	Casein Kinase II Alpha (prime) (cluster #1 Of 2), Eukaryotic	Eukaryotes	7	0.33	Binding ≤ 10μM
CSK2B-1-E	Casein Kinase II Beta (cluster #1 Of 3), Eukaryotic	Eukaryotes	7000	0.21	Binding ≤ 10μM
CTRO-1-E	Citron Rho-interacting Kinase (cluster #1 Of 1), Eukaryotic	Eukaryotes	340	0.26	Binding ≤ 10μM
DAPK1-1-E	Death-associated Protein Kinase 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1	0.36	Binding ≤ 10μM
DAPK2-1-E	Death-associated Protein Kinase 2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	3	0.34	Binding ≤ 10μM
DAPK3-1-E	Death-associated Protein Kinase 3 (cluster #1 Of 2), Eukaryotic	Eukaryotes	1500	0.23	Binding ≤ 10μM
DCLK1-1-E	Serine/threonine-protein Kinase DCLK1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	110	0.28	Binding ≤ 10μM
DCLK2-1-E	Serine/threonine-protein Kinase DCLK2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	73	0.29	Binding ≤ 10μM
DCLK3-1-E	Serine/threonine-protein Kinase DCLK3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	17	0.31	Binding ≤ 10μM
DDR1-1-E	Epithelial Discoidin Domain-containing Receptor 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	19	0.31	Binding ≤ 10μM
DDR2-1-E	Discoidin Domain-containing Receptor 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	42	0.30	Binding ≤ 10μM
DMPK-1-E	Myotonin-protein Kinase (cluster #1 Of 1), Eukaryotic	Eukaryotes	4	0.34	Binding ≤ 10μM
DYR1B-1-E	Dual Specificity Tyrosine-phosphorylation-regulated Kinase 1B (cluster #1 Of 1), Eukaryotic	Eukaryotes	28	0.30	Binding ≤ 10μM
E2AK2-1-E	Interferon-induced, Double-stranded RNA-activated Protein Kinase (cluster #1 Of 1), Eukaryotic	Eukaryotes	100	0.28	Binding ≤ 10μM
E2AK2-1-E	Interferon-induced, Double-stranded RNA-activated Protein Kinase (cluster #1 Of 1), Eukaryotic	Eukaryotes	360	0.26	Binding ≤ 10μM
E2AK4-1-E	Eukaryotic Translation Initiation Factor 2-alpha Kinase 4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	16	0.31	Binding ≤ 10μM
EGFR-1-E	Epidermal Growth Factor Receptor ErbB1 (cluster #1 Of 4), Eukaryotic	Eukaryotes	96	0.28	Binding ≤ 10μM
EPHA1-1-E	Ephrin Type-A Receptor 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	300	0.26	Binding ≤ 10μM
EPHA2-1-E	Ephrin Type-A Receptor 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	870	0.24	Binding ≤ 10μM
EPHA3-1-E	Ephrin Type-A Receptor 3 (cluster #1 Of 2), Eukaryotic	Eukaryotes	55	0.29	Binding ≤ 10μM
EPHA4-1-E	Ephrin Type-A Receptor 4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	710	0.25	Binding ≤ 10μM
EPHA5-1-E	Ephrin Type-A Receptor 5 (cluster #1 Of 1), Eukaryotic	Eukaryotes	95	0.28	Binding ≤ 10μM
EPHA6-1-E	Ephrin Type-A Receptor 6 (cluster #1 Of 1), Eukaryotic	Eukaryotes	290	0.26	Binding ≤ 10μM
EPHA7-1-E	Ephrin Type-A Receptor 7 (cluster #1 Of 1), Eukaryotic	Eukaryotes	690	0.25	Binding ≤ 10μM
EPHA8-1-E	Ephrin Type-A Receptor 8 (cluster #1 Of 1), Eukaryotic	Eukaryotes	300	0.26	Binding ≤ 10μM
EPHB1-1-E	Ephrin Type-B Receptor 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	590	0.25	Binding ≤ 10μM
EPHB2-1-E	Ephrin Type-B Receptor 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	2100	0.23	Binding ≤ 10μM
EPHB4-1-E	Ephrin Type-B Receptor 4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	233	0.27	Binding ≤ 10μM
ERBB4-1-E	Receptor Protein-tyrosine Kinase ErbB-4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	282	0.26	Binding ≤ 10μM
FAK1-1-E	Focal Adhesion Kinase 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	68	0.29	Binding ≤ 10μM
FAK2-1-E	Protein-tyrosine Kinase 2-beta (cluster #1 Of 1), Eukaryotic	Eukaryotes	4	0.34	Binding ≤ 10μM
FER-1-E	Tyrosine-protein Kinase FER (cluster #1 Of 1), Eukaryotic	Eukaryotes	30	0.30	Binding ≤ 10μM
FES-1-E	Tyrosine-protein Kinase FES (cluster #1 Of 1), Eukaryotic	Eukaryotes	23	0.31	Binding ≤ 10μM
FGFR1-1-E	Fibroblast Growth Factor Receptor 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	90	0.28	Binding ≤ 10μM
FGFR2-1-E	Fibroblast Growth Factor Receptor 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	420	0.26	Binding ≤ 10μM
FGFR3-1-E	Fibroblast Growth Factor Receptor 3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	88	0.28	Binding ≤ 10μM
FGFR4-1-E	Fibroblast Growth Factor Receptor 4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	420	0.26	Binding ≤ 10μM
FGR-1-E	Tyrosine-protein Kinase FGR (cluster #1 Of 2), Eukaryotic	Eukaryotes	30	0.30	Binding ≤ 10μM
FLT3-1-E	Tyrosine-protein Kinase Receptor FLT3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	3	0.34	Binding ≤ 10μM
FRK-1-E	Tyrosine-protein Kinase FRK (cluster #1 Of 1), Eukaryotic	Eukaryotes	45	0.29	Binding ≤ 10μM
FYN-1-E	Tyrosine-protein Kinase FYN (cluster #1 Of 5), Eukaryotic	Eukaryotes	83	0.28	Binding ≤ 10μM
GAK-1-E	Serine/threonine-protein Kinase GAK (cluster #1 Of 2), Eukaryotic	Eukaryotes	68	0.29	Binding ≤ 10μM
GSK3A-1-E	Glycogen Synthase Kinase-3 Alpha (cluster #1 Of 3), Eukaryotic	Eukaryotes	140	0.27	Binding ≤ 10μM
GSK3B-1-E	Glycogen Synthase Kinase-3 Beta (cluster #1 Of 7), Eukaryotic	Eukaryotes	89	0.28	Binding ≤ 10μM
HCK-1-E	Tyrosine-protein Kinase HCK (cluster #1 Of 1), Eukaryotic	Eukaryotes	20	0.31	Binding ≤ 10μM
HIPK1-1-E	Homeodomain-interacting Protein Kinase 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	2639	0.22	Binding ≤ 10μM
IGF1R-1-E	Insulin-like Growth Factor 1 Receptor (cluster #1 Of 2), Eukaryotic	Eukaryotes	35	0.30	Binding ≤ 10μM
IKKA-2-E	Inhibitor Of Nuclear Factor Kappa B Kinase Alpha Subunit (cluster #2 Of 3), Eukaryotic	Eukaryotes	39	0.30	Binding ≤ 10μM
IKKB-1-E	Inhibitor Of Nuclear Factor Kappa B Kinase Beta Subunit (cluster #1 Of 1), Eukaryotic	Eukaryotes	771	0.24	Binding ≤ 10μM
IKKE-1-E	Inhibitor Of Nuclear Factor Kappa B Kinase Epsilon Subunit (cluster #1 Of 1), Eukaryotic	Eukaryotes	5	0.33	Binding ≤ 10μM
INSR-1-E	Insulin Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	200	0.27	Binding ≤ 10μM
INSRR-1-E	Insulin Receptor-related Protein (cluster #1 Of 1), Eukaryotic	Eukaryotes	81	0.28	Binding ≤ 10μM
IRAK3-1-E	Interleukin-1 Receptor-associated Kinase 3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	13	0.32	Binding ≤ 10μM
IRAK4-1-E	Interleukin-1 Receptor-associated Kinase 4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	34	0.30	Binding ≤ 10μM
ITK-1-E	Tyrosine-protein Kinase ITK/TSK (cluster #1 Of 1), Eukaryotic	Eukaryotes	19	0.31	Binding ≤ 10μM
JAK2-1-E	Tyrosine-protein Kinase JAK2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	5	0.33	Binding ≤ 10μM
JAK3-1-E	Tyrosine-protein Kinase JAK3 (cluster #1 Of 2), Eukaryotic	Eukaryotes	6	0.33	Binding ≤ 10μM
KAP2-1-E	CAMP-dependent Protein Kinase Type II-alpha Regulatory Subunit (cluster #1 Of 1), Eukaryotic	Eukaryotes	100	0.28	Binding ≤ 10μM
KAPCA-1-E	CAMP-dependent Protein Kinase Alpha-catalytic Subunit (cluster #1 Of 4), Eukaryotic	Eukaryotes	27	0.30	Binding ≤ 10μM
KAPCB-1-E	CAMP-dependent Protein Kinase Beta-1 Catalytic Subunit (cluster #1 Of 3), Eukaryotic	Eukaryotes	4	0.34	Binding ≤ 10μM
KAPCG-1-E	CAMP-dependent Protein Kinase, Gamma Catalytic Subunit (cluster #1 Of 2), Eukaryotic	Eukaryotes	80	0.28	Binding ≤ 10μM
KC1A-1-E	Casein Kinase I Alpha (cluster #1 Of 1), Eukaryotic	Eukaryotes	1400	0.23	Binding ≤ 10μM
KC1AL-1-E	Casein Kinase I Isoform Alpha-like (cluster #1 Of 1), Eukaryotic	Eukaryotes	250	0.26	Binding ≤ 10μM
KC1D-1-E	Casein Kinase I Delta (cluster #1 Of 1), Eukaryotic	Eukaryotes	1400	0.23	Binding ≤ 10μM
KC1E-1-E	Casein Kinase I Epsilon (cluster #1 Of 2), Eukaryotic	Eukaryotes	1400	0.23	Binding ≤ 10μM
KC1G1-1-E	Casein Kinase I Gamma 1 (cluster #1 Of 2), Eukaryotic	Eukaryotes	1400	0.23	Binding ≤ 10μM
KC1G2-1-E	Casein Kinase I Gamma 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	780	0.24	Binding ≤ 10μM
KCC1A-1-E	CaM Kinase I Alpha (cluster #1 Of 2), Eukaryotic	Eukaryotes	40	0.30	Binding ≤ 10μM
KCC1D-1-E	CaM Kinase I Delta (cluster #1 Of 2), Eukaryotic	Eukaryotes	2	0.35	Binding ≤ 10μM
KCC1G-1-E	CaM Kinase I Gamma (cluster #1 Of 2), Eukaryotic	Eukaryotes	53	0.29	Binding ≤ 10μM
KCC2A-1-E	CaM Kinase II Alpha (cluster #1 Of 1), Eukaryotic	Eukaryotes	6	0.33	Binding ≤ 10μM
KCC2B-1-E	CaM Kinase II Beta (cluster #1 Of 1), Eukaryotic	Eukaryotes	6	0.33	Binding ≤ 10μM
KCC2D-1-E	CaM Kinase II Delta (cluster #1 Of 1), Eukaryotic	Eukaryotes	6	0.33	Binding ≤ 10μM
KCC2G-1-E	CaM Kinase II Gamma (cluster #1 Of 1), Eukaryotic	Eukaryotes	6	0.33	Binding ≤ 10μM
KCC4-1-E	CaM Kinase IV (cluster #1 Of 1), Eukaryotic	Eukaryotes	41	0.30	Binding ≤ 10μM
KGP1-1-E	CGMP-dependent Protein Kinase 1 Beta (cluster #1 Of 1), Eukaryotic	Eukaryotes	32	0.30	Binding ≤ 10μM
KGP2-1-E	CGMP-dependent Protein Kinase 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	16	0.31	Binding ≤ 10μM
KIT-1-E	Stem Cell Growth Factor Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	10	0.32	Binding ≤ 10μM
KKCC1-1-E	CaM-kinase Kinase Alpha (cluster #1 Of 1), Eukaryotic	Eukaryotes	0	0.00	Binding ≤ 10μM
KKCC2-1-E	CaM-kinase Kinase Beta (cluster #1 Of 2), Eukaryotic	Eukaryotes	0	0.00	Binding ≤ 10μM
KPB1-1-E	Phosphorylase Kinase Alpha M Subunit (cluster #1 Of 1), Eukaryotic	Eukaryotes	1	0.36	Binding ≤ 10μM
KPB2-1-E	Phosphorylase Kinase Alpha L Subunit (cluster #1 Of 1), Eukaryotic	Eukaryotes	1	0.36	Binding ≤ 10μM
KPBB-1-E	Phosphorylase Kinase Beta Subunit (cluster #1 Of 2), Eukaryotic	Eukaryotes	1	0.36	Binding ≤ 10μM
KPCA-1-E	Protein Kinase C Alpha (cluster #1 Of 6), Eukaryotic	Eukaryotes	8	0.32	Binding ≤ 10μM
KPCB-1-E	Protein Kinase C Beta (cluster #1 Of 4), Eukaryotic	Eukaryotes	9	0.32	Binding ≤ 10μM
KPCD-1-E	Protein Kinase C Delta (cluster #1 Of 4), Eukaryotic	Eukaryotes	8	0.32	Binding ≤ 10μM
KPCD1-1-E	Protein Kinase C Mu (cluster #1 Of 3), Eukaryotic	Eukaryotes	8	0.32	Binding ≤ 10μM
KPCD2-1-E	Serine/threonine-protein Kinase D2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	72	0.29	Binding ≤ 10μM
KPCD3-1-E	Protein Kinase C Nu (cluster #1 Of 3), Eukaryotic	Eukaryotes	8	0.32	Binding ≤ 10μM
KPCE-1-E	Protein Kinase C Epsilon (cluster #1 Of 5), Eukaryotic	Eukaryotes	8	0.32	Binding ≤ 10μM
KPCG-1-E	Protein Kinase C Gamma (cluster #1 Of 4), Eukaryotic	Eukaryotes	9	0.32	Binding ≤ 10μM
KPCI-1-E	Protein Kinase C Iota (cluster #1 Of 3), Eukaryotic	Eukaryotes	8	0.32	Binding ≤ 10μM
KPCL-2-E	Protein Kinase C Eta (cluster #2 Of 4), Eukaryotic	Eukaryotes	9	0.32	Binding ≤ 10μM
KPCT-1-E	Protein Kinase C Theta (cluster #1 Of 3), Eukaryotic	Eukaryotes	9	0.32	Binding ≤ 10μM
KPCZ-1-E	Protein Kinase C Zeta (cluster #1 Of 5), Eukaryotic	Eukaryotes	8	0.32	Binding ≤ 10μM
KS6A1-1-E	Ribosomal Protein S6 Kinase Alpha 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	5	0.33	Binding ≤ 10μM
KS6A2-1-E	Ribosomal Protein S6 Kinase Alpha 2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	9	0.32	Binding ≤ 10μM
KS6A3-1-E	Ribosomal Protein S6 Kinase Alpha 3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	69	0.29	Binding ≤ 10μM
KS6A4-1-E	Ribosomal Protein S6 Kinase Alpha 4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	5	0.33	Binding ≤ 10μM
KS6A5-1-E	Ribosomal Protein S6 Kinase Alpha 5 (cluster #1 Of 3), Eukaryotic	Eukaryotes	890	0.24	Binding ≤ 10μM
KS6A6-1-E	Ribosomal Protein S6 Kinase Alpha 6 (cluster #1 Of 1), Eukaryotic	Eukaryotes	5	0.33	Binding ≤ 10μM
KS6B1-1-E	Ribosomal Protein S6 Kinase 1 (cluster #1 Of 2), Eukaryotic	Eukaryotes	5	0.33	Binding ≤ 10μM
KS6B2-1-E	Ribosomal Protein S6 Kinase 2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	5	0.33	Binding ≤ 10μM
KSYK-1-E	Tyrosine-protein Kinase SYK (cluster #1 Of 2), Eukaryotic	Eukaryotes	7	0.33	Binding ≤ 10μM
LATS1-1-E	Serine/threonine-protein Kinase LATS1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	42	0.30	Binding ≤ 10μM
LATS2-1-E	Serine/threonine-protein Kinase LATS2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	17	0.31	Binding ≤ 10μM
LCK-1-E	Tyrosine-protein Kinase LCK (cluster #1 Of 4), Eukaryotic	Eukaryotes	4	0.34	Binding ≤ 10μM
LIMK1-1-E	LIM Domain Kinase 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	690	0.25	Binding ≤ 10μM
LIMK2-1-E	LIM Domain Kinase 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	9200	0.20	Binding ≤ 10μM
LTK-1-E	Leukocyte Tyrosine Kinase Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	37	0.30	Binding ≤ 10μM
LYN-1-E	Tyrosine-protein Kinase Lyn (cluster #1 Of 1), Eukaryotic	Eukaryotes	40	0.30	Binding ≤ 10μM
M3K10-1-E	Mitogen-activated Protein Kinase Kinase Kinase 10 (cluster #1 Of 1), Eukaryotic	Eukaryotes	52	0.29	Binding ≤ 10μM
M3K11-1-E	Mitogen-activated Protein Kinase Kinase Kinase 11 (cluster #1 Of 1), Eukaryotic	Eukaryotes	20	0.31	Binding ≤ 10μM
M3K14-1-E	Mitogen-activated Protein Kinase Kinase Kinase 14 (cluster #1 Of 1), Eukaryotic	Eukaryotes	2300	0.23	Binding ≤ 10μM
M3K4-1-E	Mitogen-activated Protein Kinase Kinase Kinase 4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	2200	0.23	Binding ≤ 10μM
M3K5-1-E	Mitogen-activated Protein Kinase Kinase Kinase 5 (cluster #1 Of 1), Eukaryotic	Eukaryotes	37	0.30	Binding ≤ 10μM
M3K7-1-E	Mitogen-activated Protein Kinase Kinase Kinase 7 (cluster #1 Of 1), Eukaryotic	Eukaryotes	35	0.30	Binding ≤ 10μM
M3K9-1-E	Mitogen-activated Protein Kinase Kinase Kinase 9 (cluster #1 Of 1), Eukaryotic	Eukaryotes	10	0.32	Binding ≤ 10μM
M4K1-1-E	Mitogen-activated Protein Kinase Kinase Kinase Kinase 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	4	0.34	Binding ≤ 10μM
M4K3-1-E	Mitogen-activated Protein Kinase Kinase Kinase Kinase 3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	8	0.32	Binding ≤ 10μM
M4K4-1-E	Mitogen-activated Protein Kinase Kinase Kinase Kinase 4 (cluster #1 Of 2), Eukaryotic	Eukaryotes	24	0.30	Binding ≤ 10μM
M4K5-1-E	Mitogen-activated Protein Kinase Kinase Kinase Kinase 5 (cluster #1 Of 1), Eukaryotic	Eukaryotes	26	0.30	Binding ≤ 10μM
MAPK2-1-E	MAP Kinase-activated Protein Kinase 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	880	0.24	Binding ≤ 10μM
MARK1-1-E	Serine/threonine-protein Kinase MARK1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	4	0.34	Binding ≤ 10μM
MARK2-1-E	MAP/microtubule Affinity-regulating Kinase 2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	1	0.36	Binding ≤ 10μM
MARK3-1-E	Serine/threonine-protein Kinase C-TAK1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	3	0.34	Binding ≤ 10μM
MARK4-1-E	MAP/microtubule Affinity-regulating Kinase 4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	5	0.33	Binding ≤ 10μM
MELK-1-E	Maternal Embryonic Leucine Zipper Kinase (cluster #1 Of 1), Eukaryotic	Eukaryotes	33	0.30	Binding ≤ 10μM
MERTK-1-E	Proto-oncogene Tyrosine-protein Kinase MER (cluster #1 Of 1), Eukaryotic	Eukaryotes	6	0.33	Binding ≤ 10μM
MET-1-E	Hepatocyte Growth Factor Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	190	0.27	Binding ≤ 10μM
MINK1-1-E	Misshapen-like Kinase 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	0	0.00	Binding ≤ 10μM
MK01-1-E	Mitogen-activated Protein Kinase 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	7300	0.21	Binding ≤ 10μM
MK03-1-E	MAP Kinase ERK1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	8400	0.20	Binding ≤ 10μM
MK07-1-E	Mitogen-activated Protein Kinase 7 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1600	0.23	Binding ≤ 10μM
MK08-1-E	Mitogen-activated Protein Kinase 8 (cluster #1 Of 5), Eukaryotic	Eukaryotes	520	0.25	Binding ≤ 10μM
MK09-1-E	C-Jun N-terminal Kinase 2 (cluster #1 Of 3), Eukaryotic	Eukaryotes	1100	0.24	Binding ≤ 10μM
MK10-1-E	C-Jun N-terminal Kinase 3 (cluster #1 Of 2), Eukaryotic	Eukaryotes	340	0.26	Binding ≤ 10μM
MK11-1-E	MAP Kinase P38 Beta (cluster #1 Of 1), Eukaryotic	Eukaryotes	1000	0.24	Binding ≤ 10μM
MK12-1-E	MAP Kinase P38 Gamma (cluster #1 Of 2), Eukaryotic	Eukaryotes	92	0.28	Binding ≤ 10μM
MK13-1-E	MAP Kinase P38 Delta (cluster #1 Of 1), Eukaryotic	Eukaryotes	1000	0.24	Binding ≤ 10μM
MK14-1-E	MAP Kinase P38 Alpha (cluster #1 Of 3), Eukaryotic	Eukaryotes	1000	0.24	Binding ≤ 10μM
MK15-1-E	Mitogen-activated Protein Kinase 15 (cluster #1 Of 1), Eukaryotic	Eukaryotes	35	0.30	Binding ≤ 10μM
MKNK1-1-E	MAP Kinase-interacting Serine/threonine-protein Kinase MNK1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	170	0.27	Binding ≤ 10μM
MKNK2-1-E	MAP Kinase Signal-integrating Kinase 2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	22	0.31	Binding ≤ 10μM
MP2K1-1-E	Dual Specificity Mitogen-activated Protein Kinase Kinase 1 (cluster #1 Of 4), Eukaryotic	Eukaryotes	670	0.25	Binding ≤ 10μM
MP2K2-1-E	Dual Specificity Mitogen-activated Protein Kinase Kinase 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	28	0.30	Binding ≤ 10μM
MP2K3-1-E	Dual Specificity Mitogen-activated Protein Kinase Kinase 3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	5	0.33	Binding ≤ 10μM
MP2K4-1-E	Dual Specificity Mitogen-activated Protein Kinase Kinase 4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	70	0.29	Binding ≤ 10μM
MP2K6-1-E	Dual Specificity Mitogen-activated Protein Kinase Kinase 6 (cluster #1 Of 1), Eukaryotic	Eukaryotes	3	0.34	Binding ≤ 10μM
MRCKA-1-E	Serine/threonine-protein Kinase MRCK-A (cluster #1 Of 1), Eukaryotic	Eukaryotes	57	0.29	Binding ≤ 10μM
MRCKB-1-E	Serine/threonine-protein Kinase MRCK Beta (cluster #1 Of 1), Eukaryotic	Eukaryotes	42	0.30	Binding ≤ 10μM
MRCKG-1-E	Serine/threonine-protein Kinase MRCK Gamma (cluster #1 Of 1), Eukaryotic	Eukaryotes	37	0.30	Binding ≤ 10μM
MST4-1-E	Serine/threonine-protein Kinase MST4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	140	0.27	Binding ≤ 10μM
MUSK-1-E	Muscle, Skeletal Receptor Tyrosine Protein Kinase (cluster #1 Of 1), Eukaryotic	Eukaryotes	86	0.28	Binding ≤ 10μM
MYLK-1-E	Myosin Light Chain Kinase, Smooth Muscle (cluster #1 Of 1), Eukaryotic	Eukaryotes	40	0.30	Binding ≤ 10μM
MYLK2-1-E	Myosin Light Chain Kinase 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	61	0.29	Binding ≤ 10μM
MYLK4-1-E	Myosin Light Chain Kinase Family Member 4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	470	0.25	Binding ≤ 10μM
MYO3A-1-E	Myosin IIIA (cluster #1 Of 1), Eukaryotic	Eukaryotes	500	0.25	Binding ≤ 10μM
MYO3B-1-E	Myosin-IIIB (cluster #1 Of 1), Eukaryotic	Eukaryotes	300	0.26	Binding ≤ 10μM
NEK1-1-E	Serine/threonine-protein Kinase Nek1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	860	0.24	Binding ≤ 10μM
NEK2-1-E	Serine/threonine-protein Kinase NEK2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	750	0.24	Binding ≤ 10μM
NEK5-1-E	Serine/threonine-protein Kinase Nek5 (cluster #1 Of 1), Eukaryotic	Eukaryotes	810	0.24	Binding ≤ 10μM
NEK7-1-E	Serine/threonine-protein Kinase NEK7 (cluster #1 Of 1), Eukaryotic	Eukaryotes	4500	0.21	Binding ≤ 10μM
NEK9-1-E	Serine/threonine-protein Kinase NEK9 (cluster #1 Of 1), Eukaryotic	Eukaryotes	6700	0.21	Binding ≤ 10μM
NLK-1-E	Serine/threonine Protein Kinase NLK (cluster #1 Of 1), Eukaryotic	Eukaryotes	220	0.27	Binding ≤ 10μM
NTRK1-1-E	Nerve Growth Factor Receptor Trk-A (cluster #1 Of 1), Eukaryotic	Eukaryotes	4	0.34	Binding ≤ 10μM
NTRK2-1-E	Neurotrophic Tyrosine Kinase Receptor Type 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	4	0.34	Binding ≤ 10μM
NTRK3-1-E	NT-3 Growth Factor Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	17	0.31	Binding ≤ 10μM
NUAK1-1-E	NUAK Family SNF1-like Kinase 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	4	0.34	Binding ≤ 10μM
NUAK2-1-E	NUAK Family SNF1-like Kinase 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	0	0.00	Binding ≤ 10μM
P90584-2-E	Protein Kinase Pfmrk (cluster #2 Of 2), Eukaryotic	Eukaryotes	4000	0.22	Binding ≤ 10μM
PAK1-1-E	Serine/threonine-protein Kinase PAK 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	2	0.35	Binding ≤ 10μM
PAK2-1-E	Serine/threonine-protein Kinase PAK 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	3	0.34	Binding ≤ 10μM
PAK3-1-E	Serine/threonine-protein Kinase PAK 3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	7	0.33	Binding ≤ 10μM
PAK4-1-E	Serine/threonine-protein Kinase PAK 4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	8	0.32	Binding ≤ 10μM
PAK6-1-E	Serine/threonine-protein Kinase PAK6 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1	0.36	Binding ≤ 10μM
PAK7-1-E	Serine/threonine-protein Kinase PAK7 (cluster #1 Of 1), Eukaryotic	Eukaryotes	3	0.34	Binding ≤ 10μM
PDPK1-1-E	3-phosphoinositide Dependent Protein Kinase-1 (cluster #1 Of 2), Eukaryotic	Eukaryotes	2	0.35	Binding ≤ 10μM
PGFRA-1-E	Platelet-derived Growth Factor Receptor Alpha (cluster #1 Of 2), Eukaryotic	Eukaryotes	2	0.35	Binding ≤ 10μM
PGFRB-1-E	Platelet-derived Growth Factor Receptor Beta (cluster #1 Of 1), Eukaryotic	Eukaryotes	3	0.34	Binding ≤ 10μM
PHKG1-1-E	Phosphorylase Kinase Gamma Subunit 1 (cluster #1 Of 2), Eukaryotic	Eukaryotes	3	0.34	Binding ≤ 10μM
PHKG2-1-E	Phosphorylase Kinase Gamma Subunit 2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	3	0.34	Binding ≤ 10μM
PI42B-1-E	Phosphatidylinositol-5-phosphate 4-kinase Type-2 Beta (cluster #1 Of 1), Eukaryotic	Eukaryotes	77	0.28	Binding ≤ 10μM
PI51A-1-E	Phosphatidylinositol-4-phosphate 5-kinase Type-1 Alpha (cluster #1 Of 1), Eukaryotic	Eukaryotes	43	0.29	Binding ≤ 10μM
PIM1-1-E	Serine/threonine-protein Kinase PIM1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	8	0.32	Binding ≤ 10μM
PIM2-1-E	Serine/threonine-protein Kinase PIM2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	7	0.33	Binding ≤ 10μM
PIM3-1-E	Serine/threonine-protein Kinase PIM3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1	0.36	Binding ≤ 10μM
PKN1-1-E	Protein Kinase N1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1	0.36	Binding ≤ 10μM
PKN2-1-E	Protein Kinase N2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	3	0.34	Binding ≤ 10μM
PLK1-1-E	Serine/threonine-protein Kinase PLK1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	190	0.27	Binding ≤ 10μM
PLK2-1-E	Serine/threonine-protein Kinase PLK2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	197	0.27	Binding ≤ 10μM
PLK3-1-E	Serine/threonine-protein Kinase PLK3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	910	0.24	Binding ≤ 10μM
PLK4-1-E	Serine/threonine-protein Kinase PLK4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1	0.36	Binding ≤ 10μM
PRKX-1-E	Serine/threonine-protein Kinase PRKX (cluster #1 Of 1), Eukaryotic	Eukaryotes	13	0.32	Binding ≤ 10μM
PTK6-1-E	Tyrosine-protein Kinase BRK (cluster #1 Of 1), Eukaryotic	Eukaryotes	2300	0.23	Binding ≤ 10μM
Q95J97-1-E	CAMP-dependent Protein Kinase Alpha-catalytic Subunit (cluster #1 Of 1), Eukaryotic	Eukaryotes	80	0.28	Binding ≤ 10μM
RAF1-1-E	Serine/threonine-protein Kinase RAF (cluster #1 Of 1), Eukaryotic	Eukaryotes	3	0.34	Binding ≤ 10μM
RET-1-E	Tyrosine-protein Kinase Receptor RET (cluster #1 Of 1), Eukaryotic	Eukaryotes	28	0.30	Binding ≤ 10μM
RIOK1-1-E	Serine/threonine-protein Kinase RIO1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	130	0.28	Binding ≤ 10μM
RIOK3-1-E	Serine/threonine-protein Kinase RIO3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	76	0.28	Binding ≤ 10μM
RIPK2-1-E	Serine/threonine-protein Kinase RIPK2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	5200	0.21	Binding ≤ 10μM
ROCK1-1-E	Rho-associated Protein Kinase 1 (cluster #1 Of 2), Eukaryotic	Eukaryotes	1	0.36	Binding ≤ 10μM
ROS1-1-E	Proto-oncogene Tyrosine-protein Kinase ROS (cluster #1 Of 1), Eukaryotic	Eukaryotes	30	0.30	Binding ≤ 10μM
SIK1-1-E	Serine/threonine-protein Kinase SIK1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	2	0.35	Binding ≤ 10μM
SIK2-1-E	Serine/threonine-protein Kinase SIK2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1	0.36	Binding ≤ 10μM
SLK-1-E	Serine/threonine-protein Kinase 2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	0	0.00	Binding ≤ 10μM
SRC-1-E	Tyrosine-protein Kinase SRC (cluster #1 Of 3), Eukaryotic	Eukaryotes	86	0.28	Binding ≤ 10μM
SRMS-1-E	Tyrosine-protein Kinase Srms (cluster #1 Of 1), Eukaryotic	Eukaryotes	740	0.25	Binding ≤ 10μM
SRPK1-1-E	Serine/threonine-protein Kinase SRPK1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	6	0.33	Binding ≤ 10μM
SRPK2-1-E	Serine/threonine-protein Kinase SRPK2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	67	0.29	Binding ≤ 10μM
ST17A-1-E	Serine/threonine-protein Kinase 17A (cluster #1 Of 2), Eukaryotic	Eukaryotes	23	0.31	Binding ≤ 10μM
ST17B-1-E	Serine/threonine-protein Kinase 17B (cluster #1 Of 1), Eukaryotic	Eukaryotes	26	0.30	Binding ≤ 10μM
ST32B-1-E	Serine/threonine-protein Kinase 32B (cluster #1 Of 1), Eukaryotic	Eukaryotes	98	0.28	Binding ≤ 10μM
ST32C-1-E	Serine/threonine-protein Kinase 32C (cluster #1 Of 1), Eukaryotic	Eukaryotes	310	0.26	Binding ≤ 10μM
ST38L-1-E	Serine/threonine-protein Kinase 38-like (cluster #1 Of 2), Eukaryotic	Eukaryotes	77	0.28	Binding ≤ 10μM
STK10-1-E	Serine/threonine-protein Kinase 10 (cluster #1 Of 1), Eukaryotic	Eukaryotes	0	0.00	Binding ≤ 10μM
STK11-1-E	Serine/threonine-protein Kinase 11 (cluster #1 Of 1), Eukaryotic	Eukaryotes	61	0.29	Binding ≤ 10μM
STK16-1-E	Serine/threonine-protein Kinase 16 (cluster #1 Of 1), Eukaryotic	Eukaryotes	270	0.26	Binding ≤ 10μM
STK24-1-E	Serine/threonine-protein Kinase 24 (cluster #1 Of 1), Eukaryotic	Eukaryotes	120	0.28	Binding ≤ 10μM
STK25-1-E	Serine/threonine-protein Kinase 25 (cluster #1 Of 1), Eukaryotic	Eukaryotes	110	0.28	Binding ≤ 10μM
STK3-1-E	Serine/threonine-protein Kinase MST2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	0	0.00	Binding ≤ 10μM
STK33-1-E	Serine/threonine-protein Kinase 33 (cluster #1 Of 1), Eukaryotic	Eukaryotes	2	0.35	Binding ≤ 10μM
STK36-1-E	Serine/threonine-protein Kinase 36 (cluster #1 Of 1), Eukaryotic	Eukaryotes	6700	0.21	Binding ≤ 10μM
STK4-1-E	Serine/threonine-protein Kinase MST1 (cluster #1 Of 2), Eukaryotic	Eukaryotes	0	0.00	Binding ≤ 10μM
SYK-1-E	Lysyl-tRNA Synthetase (cluster #1 Of 1), Eukaryotic	Eukaryotes	9	0.32	Binding ≤ 10μM
TAB1-1-E	Mitogen-activated Protein Kinase Kinase Kinase 7-interacting Protein 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	35	0.30	Binding ≤ 10μM
TBA1A-1-E	Tubulin Alpha-3 Chain (cluster #1 Of 3), Eukaryotic	Eukaryotes	770	0.24	Binding ≤ 10μM
TEC-1-E	Tyrosine-protein Kinase TEC (cluster #1 Of 1), Eukaryotic	Eukaryotes	1300	0.24	Binding ≤ 10μM
TESK1-1-E	Dual Specificity Testis-specific Protein Kinase 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	320	0.26	Binding ≤ 10μM
TGFR1-1-E	TGF-beta Receptor Type I (cluster #1 Of 1), Eukaryotic	Eukaryotes	2000	0.23	Binding ≤ 10μM
TIE1-1-E	Tyrosine-protein Kinase Receptor Tie-1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	65	0.29	Binding ≤ 10μM
TIE2-1-E	Tyrosine-protein Kinase TIE-2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	52	0.29	Binding ≤ 10μM
TLK1-1-E	Serine/threonine-protein Kinase Tousled-like 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	27	0.30	Binding ≤ 10μM
TLK2-1-E	Serine/threonine-protein Kinase Tousled-like 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	16	0.31	Binding ≤ 10μM
TNI3K-1-E	Serine/threonine-protein Kinase TNNI3K (cluster #1 Of 1), Eukaryotic	Eukaryotes	1000	0.24	Binding ≤ 10μM
TNIK-1-E	TRAF2- And NCK-interacting Kinase (cluster #1 Of 2), Eukaryotic	Eukaryotes	6	0.33	Binding ≤ 10μM
TNK1-1-E	Non-receptor Tyrosine-protein Kinase TNK1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	3	0.34	Binding ≤ 10μM
TSSK1-1-E	Testis-specific Serine/threonine-protein Kinase 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	24	0.30	Binding ≤ 10μM
TTK-1-E	Dual Specificity Protein Kinase TTK (cluster #1 Of 2), Eukaryotic	Eukaryotes	61	0.29	Binding ≤ 10μM
TXK-1-E	Tyrosine-protein Kinase TXK (cluster #1 Of 1), Eukaryotic	Eukaryotes	230	0.27	Binding ≤ 10μM
TYK2-1-E	Tyrosine-protein Kinase TYK2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	56	0.29	Binding ≤ 10μM
TYRO3-1-E	Tyrosine-protein Kinase Receptor TYRO3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	49	0.29	Binding ≤ 10μM
UFO-1-E	Tyrosine-protein Kinase Receptor UFO (cluster #1 Of 1), Eukaryotic	Eukaryotes	7	0.33	Binding ≤ 10μM
ULK3-1-E	Serine/threonine-protein Kinase ULK3 (cluster #1 Of 2), Eukaryotic	Eukaryotes	3	0.34	Binding ≤ 10μM
VGFR1-1-E	Vascular Endothelial Growth Factor Receptor 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	14	0.31	Binding ≤ 10μM
VGFR2-1-E	Vascular Endothelial Growth Factor Receptor 2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	88	0.28	Binding ≤ 10μM
VGFR3-1-E	Vascular Endothelial Growth Factor Receptor 3 (cluster #1 Of 2), Eukaryotic	Eukaryotes	14	0.31	Binding ≤ 10μM
WEE1-1-E	Serine/threonine-protein Kinase WEE1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1600	0.23	Binding ≤ 10μM
YES-1-E	Tyrosine-protein Kinase YES (cluster #1 Of 1), Eukaryotic	Eukaryotes	52	0.29	Binding ≤ 10μM
ZAP70-1-E	Tyrosine-protein Kinase ZAP-70 (cluster #1 Of 1), Eukaryotic	Eukaryotes	53	0.29	Binding ≤ 10μM
AKT1-1-E	Serine/threonine-protein Kinase AKT (cluster #1 Of 1), Eukaryotic	Eukaryotes	460	0.25	Functional ≤ 10μM
KPCB-1-E	Protein Kinase C Beta (cluster #1 Of 1), Eukaryotic	Eukaryotes	77	0.28	Functional ≤ 10μM
Z104294-1-O	Cyclin-dependent Kinase 5/CDK5 Activator 1 (cluster #1 Of 2), Other	Other	10	0.32	Binding ≤ 10μM
Z104295-1-O	Cyclin-dependent Kinase 4/cyclin D1 (cluster #1 Of 2), Other	Other	59	0.29	Binding ≤ 10μM
Z100081-2-O	PBMC (Peripheral Blood Mononuclear Cells) (cluster #2 Of 4), Other	Other	16	0.31	Functional ≤ 10μM
Z100201-1-O	Splenocytes (Spleen Cells) (cluster #1 Of 1), Other	Other	400	0.26	Functional ≤ 10μM
Z50425-3-O	Plasmodium Falciparum (cluster #3 Of 22), Other	Other	190	0.27	Functional ≤ 10μM
Z50512-1-O	Cavia Porcellus (cluster #1 Of 7), Other	Other	7500	0.20	Functional ≤ 10μM
Z80120-1-O	DLD-1 (Colon Adenocarcinoma Cells) (cluster #1 Of 5), Other	Other	9	0.32	Functional ≤ 10μM
Z80166-1-O	HT-29 (Colon Adenocarcinoma Cells) (cluster #1 Of 12), Other	Other	3	0.34	Functional ≤ 10μM
Z80211-1-O	LoVo (Colon Adenocarcinoma Cells) (cluster #1 Of 5), Other	Other	1	0.36	Functional ≤ 10μM
Z80224-1-O	MCF7 (Breast Carcinoma Cells) (cluster #1 Of 14), Other	Other	50	0.29	Functional ≤ 10μM
Z80800-1-O	MIA PaCa-2 (Pancreatic Carcinoma Cells) (cluster #1 Of 2), Other	Other	370	0.26	Functional ≤ 10μM
Z80928-1-O	HCT-116 (Colon Carcinoma Cells) (cluster #1 Of 9), Other	Other	6	0.33	Functional ≤ 10μM
Z80936-1-O	HEK293 (Embryonic Kidney Fibroblasts) (cluster #1 Of 4), Other	Other	77	0.28	Functional ≤ 10μM
Z81057-1-O	HUVEC (Umbilical Vein Endothelial Cells) (cluster #1 Of 4), Other	Other	4	0.34	Functional ≤ 10μM
Z81072-1-O	Jurkat (Acute Leukemic T-cells) (cluster #1 Of 10), Other	Other	71	0.29	Functional ≤ 10μM
Z81247-1-O	HeLa (Cervical Adenocarcinoma Cells) (cluster #1 Of 9), Other	Other	0	0.00	Functional ≤ 10μM

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	3.89	8.49	-39.52	3	7	1	74	467.549	2	↓ MOL2 SDF SMILES Flexibase
Hi High (pH 8-9.5)	3.89	8.85	-16.32	2	7	0	69	466.541	2	↓ MOL2 SDF SMILES Flexibase

22059475

Analogs

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Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
ALK-1-E	ALK Tyrosine Kinase Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	1	0.57	Binding ≤ 10μM

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	1.55	6.29	-62.19	2	5	-1	89	299.281	2	↓ MOL2 SDF SMILES Flexibase

13465359

Analogs

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Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
ALK-1-E	ALK Tyrosine Kinase Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	2	0.55	Binding ≤ 10μM

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	3.11	7.14	-9.9	2	4	0	62	287.322	2	↓ MOL2 SDF SMILES Flexibase

5125930

Analogs

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Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
ALK-1-E	ALK Tyrosine Kinase Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	2	0.42	Binding ≤ 10μM

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	4.96	8.93	-14.09	2	6	0	79	407.857	4	↓ MOL2 SDF SMILES Flexibase
Mid Mid (pH 6-8)	4.96	9.36	-31.76	3	6	1	81	408.865	4	↓ MOL2 SDF SMILES Flexibase

99114

Analogs

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Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
ALK-1-E	ALK Tyrosine Kinase Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	3	0.63	Binding ≤ 10μM

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	3.96	-2.54	-7.76	2	4	0	58	316.158	2	↓ MOL2 SDF SMILES Flexibase

9074095

Analogs

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Popular Name: ethyl ethyl

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And 1 More

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Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
ALK-1-E	ALK Tyrosine Kinase Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	3	0.40	Binding ≤ 10μM

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	5.78	12.65	-14.87	2	8	0	102	420.86	7	↓ MOL2 SDF SMILES Flexibase

34206690

Analogs

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Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
ALK-1-E	ALK Tyrosine Kinase Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	4	0.49	Binding ≤ 10μM

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	4.37	7.8	-50.21	1	5	-1	77	334.38	2	↓ MOL2 SDF SMILES Flexibase
Mid Mid (pH 6-8)	4.37	8.29	-21.89	2	5	0	75	335.388	2	↓ MOL2 SDF SMILES Flexibase

18205922

Analogs

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And 2 More

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Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
ALK-1-E	ALK Tyrosine Kinase Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	6	0.46	Binding ≤ 10μM

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	6.18	10.16	-16.09	2	4	0	58	347.805	3	↓ MOL2 SDF SMILES Flexibase
Hi High (pH 8-9.5)	6.18	10.95	-60.58	1	4	-1	61	346.797	3	↓ MOL2 SDF SMILES Flexibase

4342278

Analogs

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Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
ALK-1-E	ALK Tyrosine Kinase Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	9	0.54	Binding ≤ 10μM

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	3.11	-1.26	-9.25	2	7	0	103	282.259	3	↓ MOL2 SDF SMILES Flexibase

72105034

Analogs

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Popular Name: BGJ-398 BGJ-398

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Vendors

Chembo Pharma
- KB-58914
Excenen
- EX-A057

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Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
ABL1-1-E	Tyrosine-protein Kinase ABL (cluster #1 Of 1), Eukaryotic	Eukaryotes	2300	0.21	Binding ≤ 10μM
ALK-1-E	ALK Tyrosine Kinase Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	3078	0.20	Binding ≤ 10μM
BMX-1-E	Tyrosine-protein Kinase BMX (cluster #1 Of 1), Eukaryotic	Eukaryotes	3405	0.20	Binding ≤ 10μM
EPHB1-1-E	Ephrin Type-B Receptor 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	3039	0.20	Binding ≤ 10μM
FGFR1-1-E	Fibroblast Growth Factor Receptor 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	5	0.31	Binding ≤ 10μM
FGFR2-1-E	Fibroblast Growth Factor Receptor 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	5	0.31	Binding ≤ 10μM
FGFR3-1-E	Fibroblast Growth Factor Receptor 3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	2	0.32	Binding ≤ 10μM
FGFR4-1-E	Fibroblast Growth Factor Receptor 4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	60	0.27	Binding ≤ 10μM
FLT3-1-E	Tyrosine-protein Kinase Receptor FLT3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	3252	0.20	Binding ≤ 10μM
FYN-1-E	Tyrosine-protein Kinase FYN (cluster #1 Of 5), Eukaryotic	Eukaryotes	1900	0.21	Binding ≤ 10μM
INSR-1-E	Insulin Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	3371	0.20	Binding ≤ 10μM
JAK2-1-E	Tyrosine-protein Kinase JAK2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	2882	0.20	Binding ≤ 10μM
KIT-1-E	Stem Cell Growth Factor Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	750	0.23	Binding ≤ 10μM
KSYK-1-E	Tyrosine-protein Kinase SYK (cluster #1 Of 2), Eukaryotic	Eukaryotes	5358	0.19	Binding ≤ 10μM
LCK-1-E	Tyrosine-protein Kinase LCK (cluster #1 Of 4), Eukaryotic	Eukaryotes	2500	0.21	Binding ≤ 10μM
LYN-1-E	Tyrosine-protein Kinase Lyn (cluster #1 Of 1), Eukaryotic	Eukaryotes	3019	0.20	Binding ≤ 10μM
MET-1-E	Hepatocyte Growth Factor Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	3011	0.20	Binding ≤ 10μM
NTRK2-1-E	Neurotrophic Tyrosine Kinase Receptor Type 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	3139	0.20	Binding ≤ 10μM
PGFRA-1-E	Platelet-derived Growth Factor Receptor Alpha (cluster #1 Of 2), Eukaryotic	Eukaryotes	2718	0.21	Binding ≤ 10μM
RET-1-E	Tyrosine-protein Kinase Receptor RET (cluster #1 Of 1), Eukaryotic	Eukaryotes	3352	0.20	Binding ≤ 10μM
RON-1-E	Macrophage-stimulating Protein Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	2891	0.20	Binding ≤ 10μM
ROS1-1-E	Proto-oncogene Tyrosine-protein Kinase ROS (cluster #1 Of 1), Eukaryotic	Eukaryotes	3263	0.20	Binding ≤ 10μM
SRC-1-E	Tyrosine-protein Kinase SRC (cluster #1 Of 3), Eukaryotic	Eukaryotes	2969	0.20	Binding ≤ 10μM
TIE2-1-E	Tyrosine-protein Kinase TIE-2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	2051	0.21	Binding ≤ 10μM
TYK2-1-E	Tyrosine-protein Kinase TYK2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	3303	0.20	Binding ≤ 10μM
VGFR1-1-E	Vascular Endothelial Growth Factor Receptor 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1510	0.21	Binding ≤ 10μM
VGFR2-1-E	Vascular Endothelial Growth Factor Receptor 2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	938	0.22	Binding ≤ 10μM
VGFR3-1-E	Vascular Endothelial Growth Factor Receptor 3 (cluster #1 Of 2), Eukaryotic	Eukaryotes	2072	0.21	Binding ≤ 10μM
YES-1-E	Tyrosine-protein Kinase YES (cluster #1 Of 1), Eukaryotic	Eukaryotes	1100	0.22	Binding ≤ 10μM
Z103410-1-O	SW780 (cluster #1 Of 1), Other	Other	32	0.28	Functional ≤ 10μM
Z80036-1-O	BaF3 (IL-3-dependent Pro-B-cells) (cluster #1 Of 3), Other	Other	2	0.32	Functional ≤ 10μM
Z80996-1-O	HT1197 (Bladder Carcinoma Cells) (cluster #1 Of 1), Other	Other	1157	0.22	Functional ≤ 10μM
Z80036-1-O	BaF3 (IL-3-dependent Pro-B-cells) (cluster #1 Of 1), Other	Other	1857	0.21	ADME/T ≤ 10μM

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	5.54	13.65	-51.03	3	10	1	96	561.494	8	↓ MOL2 SDF SMILES Flexibase
Ref Reference (pH 7)	5.17	11.81	-46.83	3	10	1	100	561.494	9	↓ MOL2 SDF SMILES Flexibase
Mid Mid (pH 6-8)	5.54	11.43	-18.46	2	10	0	95	560.486	8	↓ MOL2 SDF SMILES Flexibase

3938688

Analogs

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Popular Name: JNJ-7706621 JNJ-7706621

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Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
AAK1-1-E	Adaptor-associated Kinase (cluster #1 Of 2), Eukaryotic	Eukaryotes	200	0.35	Binding ≤ 10μM
AAPK1-1-E	AMP-activated Protein Kinase, Alpha-1 Subunit (cluster #1 Of 1), Eukaryotic	Eukaryotes	1700	0.30	Binding ≤ 10μM
AAPK2-1-E	AMP-activated Protein Kinase, Alpha-2 Subunit (cluster #1 Of 1), Eukaryotic	Eukaryotes	1800	0.30	Binding ≤ 10μM
ABL1-1-E	Tyrosine-protein Kinase ABL (cluster #1 Of 1), Eukaryotic	Eukaryotes	820	0.32	Binding ≤ 10μM
ACVL1-1-E	Serine/threonine-protein Kinase Receptor R3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	2900	0.29	Binding ≤ 10μM
ACVR1-1-E	Activin Receptor Type-1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	5900	0.27	Binding ≤ 10μM
ADCK3-1-E	Chaperone Activity Of Bc1 Complex-like, Mitochondrial (cluster #1 Of 1), Eukaryotic	Eukaryotes	1200	0.31	Binding ≤ 10μM
ALK-1-E	ALK Tyrosine Kinase Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	7100	0.27	Binding ≤ 10μM
ANKK1-1-E	Ankyrin Repeat And Protein Kinase Domain-containing Protein 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	500	0.33	Binding ≤ 10μM
AURKA-3-E	Serine/threonine-protein Kinase Aurora-A (cluster #3 Of 3), Eukaryotic	Eukaryotes	250	0.34	Binding ≤ 10μM
AURKB-1-E	Serine/threonine-protein Kinase Aurora-B (cluster #1 Of 2), Eukaryotic	Eukaryotes	160	0.35	Binding ≤ 10μM
AURKC-1-E	Serine/threonine-protein Kinase Aurora-C (cluster #1 Of 2), Eukaryotic	Eukaryotes	86	0.37	Binding ≤ 10μM
AVR2A-1-E	Activin Receptor Type-2A (cluster #1 Of 1), Eukaryotic	Eukaryotes	2900	0.29	Binding ≤ 10μM
AVR2B-1-E	Activin Receptor Type-2B (cluster #1 Of 1), Eukaryotic	Eukaryotes	5900	0.27	Binding ≤ 10μM
BMP2K-1-E	BMP-2-inducible Protein Kinase (cluster #1 Of 2), Eukaryotic	Eukaryotes	180	0.35	Binding ≤ 10μM
BMPR2-1-E	Bone Morphogenetic Protein Receptor Type-2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	880	0.31	Binding ≤ 10μM
BMX-1-E	Tyrosine-protein Kinase BMX (cluster #1 Of 1), Eukaryotic	Eukaryotes	4700	0.28	Binding ≤ 10μM
BRSK1-1-E	BR Serine/threonine-protein Kinase 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	6500	0.27	Binding ≤ 10μM
BRSK2-1-E	BR Serine/threonine-protein Kinase 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	2700	0.29	Binding ≤ 10μM
CCNA1-1-E	Cyclin A1 (cluster #1 Of 3), Eukaryotic	Eukaryotes	2	0.45	Binding ≤ 10μM
CCNA2-1-E	Cyclin A2 (cluster #1 Of 3), Eukaryotic	Eukaryotes	2	0.45	Binding ≤ 10μM
CCNB1-1-E	G2/mitotic-specific Cyclin B1 (cluster #1 Of 2), Eukaryotic	Eukaryotes	6	0.43	Binding ≤ 10μM
CCNB2-1-E	G2/mitotic-specific Cyclin B2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	6	0.43	Binding ≤ 10μM
CCNB3-1-E	G2/mitotic-specific Cyclin B3 (cluster #1 Of 2), Eukaryotic	Eukaryotes	6	0.43	Binding ≤ 10μM
CD11A-1-E	PITSLRE Serine/threonine-protein Kinase CDC2L2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	110	0.36	Binding ≤ 10μM
CD11B-1-E	PITSLRE Serine/threonine-protein Kinase CDC2L1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	150	0.35	Binding ≤ 10μM
CDK1-1-E	Cyclin-dependent Kinase 1 (cluster #1 Of 4), Eukaryotic	Eukaryotes	6	0.43	Binding ≤ 10μM
CDK14-1-E	Serine/threonine-protein Kinase PFTAIRE-1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	3600	0.28	Binding ≤ 10μM
CDK16-1-E	Serine/threonine-protein Kinase PCTAIRE-1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	23	0.40	Binding ≤ 10μM
CDK17-1-E	Serine/threonine-protein Kinase PCTAIRE-2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	290	0.34	Binding ≤ 10μM
CDK18-1-E	Serine/threonine-protein Kinase PCTAIRE-3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	2100	0.29	Binding ≤ 10μM
CDK2-1-E	Cyclin-dependent Kinase 2 (cluster #1 Of 5), Eukaryotic	Eukaryotes	23	0.40	Binding ≤ 10μM
CDK3-1-E	Cyclin-dependent Kinase 3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	180	0.35	Binding ≤ 10μM
CDK5-1-E	Cyclin-dependent Kinase 5 (cluster #1 Of 1), Eukaryotic	Eukaryotes	240	0.34	Binding ≤ 10μM
CDK7-1-E	Cyclin-dependent Kinase 7 (cluster #1 Of 1), Eukaryotic	Eukaryotes	760	0.32	Binding ≤ 10μM
CDK9-1-E	Cyclin-dependent Kinase 9 (cluster #1 Of 2), Eukaryotic	Eukaryotes	470	0.33	Binding ≤ 10μM
CLK1-1-E	Dual Specificty Protein Kinase CLK1 (cluster #1 Of 2), Eukaryotic	Eukaryotes	660	0.32	Binding ≤ 10μM
CLK2-1-E	Dual Specificity Protein Kinase CLK2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	290	0.34	Binding ≤ 10μM
CLK3-1-E	Dual Specificity Protein Kinase CLK3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	310	0.34	Binding ≤ 10μM
CLK4-1-E	Dual Specificity Protein Kinase CLK4 (cluster #1 Of 2), Eukaryotic	Eukaryotes	1700	0.30	Binding ≤ 10μM
CSF1R-1-E	Macrophage Colony-stimulating Factor 1 Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	4200	0.28	Binding ≤ 10μM
CSK22-1-E	Casein Kinase II Alpha (prime) (cluster #1 Of 2), Eukaryotic	Eukaryotes	2000	0.30	Binding ≤ 10μM
DAPK3-1-E	Death-associated Protein Kinase 3 (cluster #1 Of 2), Eukaryotic	Eukaryotes	5200	0.27	Binding ≤ 10μM
DCLK1-1-E	Serine/threonine-protein Kinase DCLK1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	2500	0.29	Binding ≤ 10μM
DCLK2-1-E	Serine/threonine-protein Kinase DCLK2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	4500	0.28	Binding ≤ 10μM
DCLK3-1-E	Serine/threonine-protein Kinase DCLK3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	6500	0.27	Binding ≤ 10μM
DMPK-1-E	Myotonin-protein Kinase (cluster #1 Of 1), Eukaryotic	Eukaryotes	1200	0.31	Binding ≤ 10μM
E2AK2-1-E	Interferon-induced, Double-stranded RNA-activated Protein Kinase (cluster #1 Of 1), Eukaryotic	Eukaryotes	6300	0.27	Binding ≤ 10μM
E2AK4-1-E	Eukaryotic Translation Initiation Factor 2-alpha Kinase 4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	3900	0.28	Binding ≤ 10μM
EPHA7-1-E	Ephrin Type-A Receptor 7 (cluster #1 Of 1), Eukaryotic	Eukaryotes	3100	0.29	Binding ≤ 10μM
FGFR1-1-E	Fibroblast Growth Factor Receptor 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	810	0.32	Binding ≤ 10μM
FGFR2-1-E	Fibroblast Growth Factor Receptor 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	680	0.32	Binding ≤ 10μM
FGFR3-1-E	Fibroblast Growth Factor Receptor 3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	690	0.32	Binding ≤ 10μM
FGR-1-E	Tyrosine-protein Kinase FGR (cluster #1 Of 2), Eukaryotic	Eukaryotes	2000	0.30	Binding ≤ 10μM
FLT3-1-E	Tyrosine-protein Kinase Receptor FLT3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	850	0.31	Binding ≤ 10μM
GAK-1-E	Serine/threonine-protein Kinase GAK (cluster #1 Of 2), Eukaryotic	Eukaryotes	2400	0.29	Binding ≤ 10μM
GSK3A-1-E	Glycogen Synthase Kinase-3 Alpha (cluster #1 Of 3), Eukaryotic	Eukaryotes	41	0.38	Binding ≤ 10μM
GSK3B-1-E	Glycogen Synthase Kinase-3 Beta (cluster #1 Of 7), Eukaryotic	Eukaryotes	950	0.31	Binding ≤ 10μM
IKKE-1-E	Inhibitor Of Nuclear Factor Kappa B Kinase Epsilon Subunit (cluster #1 Of 1), Eukaryotic	Eukaryotes	8300	0.26	Binding ≤ 10μM
IRAK3-1-E	Interleukin-1 Receptor-associated Kinase 3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	3400	0.28	Binding ≤ 10μM
JAK1-1-E	Tyrosine-protein Kinase JAK1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	21	0.40	Binding ≤ 10μM
JAK2-1-E	Tyrosine-protein Kinase JAK2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	220	0.35	Binding ≤ 10μM
JAK3-1-E	Tyrosine-protein Kinase JAK3 (cluster #1 Of 2), Eukaryotic	Eukaryotes	180	0.35	Binding ≤ 10μM
KC1E-1-E	Casein Kinase I Epsilon (cluster #1 Of 2), Eukaryotic	Eukaryotes	3600	0.28	Binding ≤ 10μM
KC1G1-1-E	Casein Kinase I Gamma 1 (cluster #1 Of 2), Eukaryotic	Eukaryotes	1200	0.31	Binding ≤ 10μM
KC1G2-1-E	Casein Kinase I Gamma 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	740	0.32	Binding ≤ 10μM
KC1G3-1-E	Casein Kinase I Isoform Gamma-3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	7900	0.26	Binding ≤ 10μM
KIT-1-E	Stem Cell Growth Factor Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	590	0.32	Binding ≤ 10μM
KKCC1-1-E	CaM-kinase Kinase Alpha (cluster #1 Of 1), Eukaryotic	Eukaryotes	2900	0.29	Binding ≤ 10μM
KKCC2-1-E	CaM-kinase Kinase Beta (cluster #1 Of 2), Eukaryotic	Eukaryotes	2600	0.29	Binding ≤ 10μM
KPCD-1-E	Protein Kinase C Delta (cluster #1 Of 4), Eukaryotic	Eukaryotes	4500	0.28	Binding ≤ 10μM
KPCD1-1-E	Protein Kinase C Mu (cluster #1 Of 3), Eukaryotic	Eukaryotes	8400	0.26	Binding ≤ 10μM
KPCD3-1-E	Protein Kinase C Nu (cluster #1 Of 3), Eukaryotic	Eukaryotes	4200	0.28	Binding ≤ 10μM
KPCT-1-E	Protein Kinase C Theta (cluster #1 Of 3), Eukaryotic	Eukaryotes	4400	0.28	Binding ≤ 10μM
KS6A1-1-E	Ribosomal Protein S6 Kinase Alpha 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	4000	0.28	Binding ≤ 10μM
KS6A2-1-E	Ribosomal Protein S6 Kinase Alpha 2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	410	0.33	Binding ≤ 10μM
KS6A4-1-E	Ribosomal Protein S6 Kinase Alpha 4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	3000	0.29	Binding ≤ 10μM
KSYK-1-E	Tyrosine-protein Kinase SYK (cluster #1 Of 2), Eukaryotic	Eukaryotes	1300	0.31	Binding ≤ 10μM
LIMK1-1-E	LIM Domain Kinase 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	620	0.32	Binding ≤ 10μM
LIMK2-1-E	LIM Domain Kinase 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1000	0.31	Binding ≤ 10μM
M3K9-1-E	Mitogen-activated Protein Kinase Kinase Kinase 9 (cluster #1 Of 1), Eukaryotic	Eukaryotes	3600	0.28	Binding ≤ 10μM
M4K1-1-E	Mitogen-activated Protein Kinase Kinase Kinase Kinase 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	120	0.36	Binding ≤ 10μM
M4K3-1-E	Mitogen-activated Protein Kinase Kinase Kinase Kinase 3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	820	0.32	Binding ≤ 10μM
M4K5-1-E	Mitogen-activated Protein Kinase Kinase Kinase Kinase 5 (cluster #1 Of 1), Eukaryotic	Eukaryotes	2100	0.29	Binding ≤ 10μM
MARK1-1-E	Serine/threonine-protein Kinase MARK1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	620	0.32	Binding ≤ 10μM
MARK2-1-E	MAP/microtubule Affinity-regulating Kinase 2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	1200	0.31	Binding ≤ 10μM
MARK3-1-E	Serine/threonine-protein Kinase C-TAK1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	600	0.32	Binding ≤ 10μM
MARK4-1-E	MAP/microtubule Affinity-regulating Kinase 4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	660	0.32	Binding ≤ 10μM
MERTK-1-E	Proto-oncogene Tyrosine-protein Kinase MER (cluster #1 Of 1), Eukaryotic	Eukaryotes	2800	0.29	Binding ≤ 10μM
MET-1-E	Hepatocyte Growth Factor Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	650	0.32	Binding ≤ 10μM
MK04-1-E	Mitogen-activated Protein Kinase 4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1600	0.30	Binding ≤ 10μM
MK06-1-E	Mitogen-activated Protein Kinase 6 (cluster #1 Of 1), Eukaryotic	Eukaryotes	480	0.33	Binding ≤ 10μM
MK07-1-E	Mitogen-activated Protein Kinase 7 (cluster #1 Of 1), Eukaryotic	Eukaryotes	520	0.33	Binding ≤ 10μM
MK08-1-E	Mitogen-activated Protein Kinase 8 (cluster #1 Of 5), Eukaryotic	Eukaryotes	1700	0.30	Binding ≤ 10μM
MK10-1-E	C-Jun N-terminal Kinase 3 (cluster #1 Of 2), Eukaryotic	Eukaryotes	1300	0.31	Binding ≤ 10μM
MK15-1-E	Mitogen-activated Protein Kinase 15 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1100	0.31	Binding ≤ 10μM
MP2K1-1-E	Dual Specificity Mitogen-activated Protein Kinase Kinase 1 (cluster #1 Of 4), Eukaryotic	Eukaryotes	1800	0.30	Binding ≤ 10μM
MP2K2-1-E	Dual Specificity Mitogen-activated Protein Kinase Kinase 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	5600	0.27	Binding ≤ 10μM
MP2K3-1-E	Dual Specificity Mitogen-activated Protein Kinase Kinase 3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1500	0.30	Binding ≤ 10μM
MP2K4-1-E	Dual Specificity Mitogen-activated Protein Kinase Kinase 4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	630	0.32	Binding ≤ 10μM
MP2K6-1-E	Dual Specificity Mitogen-activated Protein Kinase Kinase 6 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1000	0.31	Binding ≤ 10μM
MST4-1-E	Serine/threonine-protein Kinase MST4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	210	0.35	Binding ≤ 10μM
MYLK-1-E	Myosin Light Chain Kinase, Smooth Muscle (cluster #1 Of 1), Eukaryotic	Eukaryotes	2100	0.29	Binding ≤ 10μM
NUAK1-1-E	NUAK Family SNF1-like Kinase 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	180	0.35	Binding ≤ 10μM
NUAK2-1-E	NUAK Family SNF1-like Kinase 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	26	0.39	Binding ≤ 10μM
PAK3-1-E	Serine/threonine-protein Kinase PAK 3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	2100	0.29	Binding ≤ 10μM
PAK4-1-E	Serine/threonine-protein Kinase PAK 4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	2300	0.29	Binding ≤ 10μM
PAK6-1-E	Serine/threonine-protein Kinase PAK6 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1400	0.30	Binding ≤ 10μM
PAK7-1-E	Serine/threonine-protein Kinase PAK7 (cluster #1 Of 1), Eukaryotic	Eukaryotes	830	0.32	Binding ≤ 10μM
PDPK1-1-E	3-phosphoinositide Dependent Protein Kinase-1 (cluster #1 Of 2), Eukaryotic	Eukaryotes	3100	0.29	Binding ≤ 10μM
PGFRA-1-E	Platelet-derived Growth Factor Receptor Alpha (cluster #1 Of 2), Eukaryotic	Eukaryotes	4000	0.28	Binding ≤ 10μM
PGFRB-1-E	Platelet-derived Growth Factor Receptor Beta (cluster #1 Of 1), Eukaryotic	Eukaryotes	910	0.31	Binding ≤ 10μM
PI42B-1-E	Phosphatidylinositol-5-phosphate 4-kinase Type-2 Beta (cluster #1 Of 1), Eukaryotic	Eukaryotes	1300	0.31	Binding ≤ 10μM
PI51A-1-E	Phosphatidylinositol-4-phosphate 5-kinase Type-1 Alpha (cluster #1 Of 1), Eukaryotic	Eukaryotes	9200	0.26	Binding ≤ 10μM
PKN2-1-E	Protein Kinase N2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1900	0.30	Binding ≤ 10μM
PLK1-1-E	Serine/threonine-protein Kinase PLK1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	5000	0.27	Binding ≤ 10μM
PLK3-1-E	Serine/threonine-protein Kinase PLK3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	7100	0.27	Binding ≤ 10μM
PLK4-1-E	Serine/threonine-protein Kinase PLK4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	120	0.36	Binding ≤ 10μM
RET-1-E	Tyrosine-protein Kinase Receptor RET (cluster #1 Of 1), Eukaryotic	Eukaryotes	4200	0.28	Binding ≤ 10μM
RIOK1-1-E	Serine/threonine-protein Kinase RIO1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1100	0.31	Binding ≤ 10μM
RIOK3-1-E	Serine/threonine-protein Kinase RIO3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1200	0.31	Binding ≤ 10μM
RIPK1-1-E	Receptor-interacting Serine/threonine-protein Kinase 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1800	0.30	Binding ≤ 10μM
SIK1-1-E	Serine/threonine-protein Kinase SIK1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	2200	0.29	Binding ≤ 10μM
SIK2-1-E	Serine/threonine-protein Kinase SIK2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1600	0.30	Binding ≤ 10μM
SLK-1-E	Serine/threonine-protein Kinase 2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	48	0.38	Binding ≤ 10μM
SRPK1-1-E	Serine/threonine-protein Kinase SRPK1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	2800	0.29	Binding ≤ 10μM
ST17A-1-E	Serine/threonine-protein Kinase 17A (cluster #1 Of 2), Eukaryotic	Eukaryotes	5600	0.27	Binding ≤ 10μM
STK10-1-E	Serine/threonine-protein Kinase 10 (cluster #1 Of 1), Eukaryotic	Eukaryotes	110	0.36	Binding ≤ 10μM
STK16-1-E	Serine/threonine-protein Kinase 16 (cluster #1 Of 1), Eukaryotic	Eukaryotes	140	0.36	Binding ≤ 10μM
STK24-1-E	Serine/threonine-protein Kinase 24 (cluster #1 Of 1), Eukaryotic	Eukaryotes	180	0.35	Binding ≤ 10μM
STK25-1-E	Serine/threonine-protein Kinase 25 (cluster #1 Of 1), Eukaryotic	Eukaryotes	360	0.33	Binding ≤ 10μM
STK3-1-E	Serine/threonine-protein Kinase MST2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	61	0.37	Binding ≤ 10μM
STK4-1-E	Serine/threonine-protein Kinase MST1 (cluster #1 Of 2), Eukaryotic	Eukaryotes	130	0.36	Binding ≤ 10μM
TEC-1-E	Tyrosine-protein Kinase TEC (cluster #1 Of 1), Eukaryotic	Eukaryotes	1000	0.31	Binding ≤ 10μM
TESK1-1-E	Dual Specificity Testis-specific Protein Kinase 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	3100	0.29	Binding ≤ 10μM
TIE1-1-E	Tyrosine-protein Kinase Receptor Tie-1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	260	0.34	Binding ≤ 10μM
TIE2-1-E	Tyrosine-protein Kinase TIE-2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	950	0.31	Binding ≤ 10μM
TLK1-1-E	Serine/threonine-protein Kinase Tousled-like 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1100	0.31	Binding ≤ 10μM
TLK2-1-E	Serine/threonine-protein Kinase Tousled-like 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	750	0.32	Binding ≤ 10μM
TNI3K-1-E	Serine/threonine-protein Kinase TNNI3K (cluster #1 Of 1), Eukaryotic	Eukaryotes	1400	0.30	Binding ≤ 10μM
TTK-1-E	Dual Specificity Protein Kinase TTK (cluster #1 Of 2), Eukaryotic	Eukaryotes	190	0.35	Binding ≤ 10μM
TYK2-1-E	Tyrosine-protein Kinase TYK2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	32	0.39	Binding ≤ 10μM
UFO-1-E	Tyrosine-protein Kinase Receptor UFO (cluster #1 Of 1), Eukaryotic	Eukaryotes	2200	0.29	Binding ≤ 10μM
VGFR1-1-E	Vascular Endothelial Growth Factor Receptor 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	2100	0.29	Binding ≤ 10μM
VGFR2-1-E	Vascular Endothelial Growth Factor Receptor 2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	3700	0.28	Binding ≤ 10μM
VGFR3-1-E	Vascular Endothelial Growth Factor Receptor 3 (cluster #1 Of 2), Eukaryotic	Eukaryotes	1100	0.31	Binding ≤ 10μM
Z104295-1-O	Cyclin-dependent Kinase 4/cyclin D1 (cluster #1 Of 2), Other	Other	110	0.36	Binding ≤ 10μM
Z80018-2-O	A-375 (Malignant Melanoma Cells) (cluster #2 Of 4), Other	Other	450	0.33	Functional ≤ 10μM
Z80390-1-O	PC-3 (Prostate Carcinoma Cells) (cluster #1 Of 10), Other	Other	120	0.36	Functional ≤ 10μM
Z80493-1-O	SK-OV-3 (Ovarian Carcinoma Cells) (cluster #1 Of 6), Other	Other	750	0.32	Functional ≤ 10μM
Z80928-3-O	HCT-116 (Colon Carcinoma Cells) (cluster #3 Of 9), Other	Other	254	0.34	Functional ≤ 10μM
Z81247-1-O	HeLa (Cervical Adenocarcinoma Cells) (cluster #1 Of 9), Other	Other	284	0.34	Functional ≤ 10μM
Z81252-3-O	MDA-MB-231 (Breast Adenocarcinoma Cells) (cluster #3 Of 11), Other	Other	590	0.32	Functional ≤ 10μM

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	1.97	5.91	-18.67	5	9	0	146	394.363	4	↓ MOL2 SDF SMILES Flexibase

6718813

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: ABT-869 ABT-869

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Vendors

And 17 More

Activity (Go SEA)

Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
ABL1-1-E	Tyrosine-protein Kinase ABL (cluster #1 Of 1), Eukaryotic	Eukaryotes	1700	0.29	Binding ≤ 10μM
ALK-1-E	ALK Tyrosine Kinase Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	1600	0.29	Binding ≤ 10μM
AURKA-2-E	Serine/threonine-protein Kinase Aurora-A (cluster #2 Of 3), Eukaryotic	Eukaryotes	760	0.31	Binding ≤ 10μM
AURKB-1-E	Serine/threonine-protein Kinase Aurora-B (cluster #1 Of 2), Eukaryotic	Eukaryotes	390	0.32	Binding ≤ 10μM
AURKC-2-E	Serine/threonine-protein Kinase Aurora-C (cluster #2 Of 2), Eukaryotic	Eukaryotes	71	0.36	Binding ≤ 10μM
BMPR2-1-E	Bone Morphogenetic Protein Receptor Type-2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	7800	0.26	Binding ≤ 10μM
CD11A-1-E	PITSLRE Serine/threonine-protein Kinase CDC2L2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1200	0.30	Binding ≤ 10μM
CD11B-1-E	PITSLRE Serine/threonine-protein Kinase CDC2L1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1300	0.29	Binding ≤ 10μM
CDK1-3-E	Cyclin-dependent Kinase 1 (cluster #3 Of 4), Eukaryotic	Eukaryotes	9800	0.25	Binding ≤ 10μM
CDK19-1-E	Cell Division Cycle 2-like Protein Kinase 6 (cluster #1 Of 1), Eukaryotic	Eukaryotes	74	0.36	Binding ≤ 10μM
CDK7-1-E	Cyclin-dependent Kinase 7 (cluster #1 Of 1), Eukaryotic	Eukaryotes	2900	0.28	Binding ≤ 10μM
CDK8-1-E	Cell Division Protein Kinase 8 (cluster #1 Of 1), Eukaryotic	Eukaryotes	95	0.35	Binding ≤ 10μM
CDK9-1-E	Cyclin-dependent Kinase 9 (cluster #1 Of 2), Eukaryotic	Eukaryotes	3000	0.28	Binding ≤ 10μM
CLK1-2-E	Dual Specificty Protein Kinase CLK1 (cluster #2 Of 2), Eukaryotic	Eukaryotes	8900	0.25	Binding ≤ 10μM
CLK4-2-E	Dual Specificity Protein Kinase CLK4 (cluster #2 Of 2), Eukaryotic	Eukaryotes	1600	0.29	Binding ≤ 10μM
CSF1R-1-E	Macrophage Colony-stimulating Factor 1 Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	3	0.43	Binding ≤ 10μM
DDR1-1-E	Epithelial Discoidin Domain-containing Receptor 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	58	0.36	Binding ≤ 10μM
DDR2-1-E	Discoidin Domain-containing Receptor 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	3800	0.27	Binding ≤ 10μM
EGFR-1-E	Epidermal Growth Factor Receptor ErbB1 (cluster #1 Of 4), Eukaryotic	Eukaryotes	6500	0.26	Binding ≤ 10μM
EPHA3-1-E	Ephrin Type-A Receptor 3 (cluster #1 Of 2), Eukaryotic	Eukaryotes	3500	0.27	Binding ≤ 10μM
EPHA6-1-E	Ephrin Type-A Receptor 6 (cluster #1 Of 1), Eukaryotic	Eukaryotes	330	0.32	Binding ≤ 10μM
EPHB3-1-E	Ephrin Type-B Receptor 3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1400	0.29	Binding ≤ 10μM
EPHB4-1-E	Ephrin Type-B Receptor 4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1400	0.29	Binding ≤ 10μM
FLT3-1-E	Tyrosine-protein Kinase Receptor FLT3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	9	0.40	Binding ≤ 10μM
FRK-1-E	Tyrosine-protein Kinase FRK (cluster #1 Of 1), Eukaryotic	Eukaryotes	400	0.32	Binding ≤ 10μM
INSRR-1-E	Insulin Receptor-related Protein (cluster #1 Of 1), Eukaryotic	Eukaryotes	3900	0.27	Binding ≤ 10μM
KAPCA-1-E	CAMP-dependent Protein Kinase Alpha-catalytic Subunit (cluster #1 Of 4), Eukaryotic	Eukaryotes	6900	0.26	Binding ≤ 10μM
KIT-1-E	Stem Cell Growth Factor Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	81	0.35	Binding ≤ 10μM
KS6A4-1-E	Ribosomal Protein S6 Kinase Alpha 4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	7200	0.26	Binding ≤ 10μM
KS6A5-1-E	Ribosomal Protein S6 Kinase Alpha 5 (cluster #1 Of 3), Eukaryotic	Eukaryotes	1200	0.30	Binding ≤ 10μM
LATS2-1-E	Serine/threonine-protein Kinase LATS2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1700	0.29	Binding ≤ 10μM
LIMK2-1-E	LIM Domain Kinase 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	4700	0.27	Binding ≤ 10μM
LTK-1-E	Leukocyte Tyrosine Kinase Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	550	0.31	Binding ≤ 10μM
M4K1-1-E	Mitogen-activated Protein Kinase Kinase Kinase Kinase 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	830	0.30	Binding ≤ 10μM
M4K3-1-E	Mitogen-activated Protein Kinase Kinase Kinase Kinase 3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	3200	0.27	Binding ≤ 10μM
M4K5-1-E	Mitogen-activated Protein Kinase Kinase Kinase Kinase 5 (cluster #1 Of 1), Eukaryotic	Eukaryotes	910	0.30	Binding ≤ 10μM
MERTK-1-E	Proto-oncogene Tyrosine-protein Kinase MER (cluster #1 Of 1), Eukaryotic	Eukaryotes	870	0.30	Binding ≤ 10μM
MET-1-E	Hepatocyte Growth Factor Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	1300	0.29	Binding ≤ 10μM
MK09-1-E	C-Jun N-terminal Kinase 2 (cluster #1 Of 3), Eukaryotic	Eukaryotes	240	0.33	Binding ≤ 10μM
MK15-1-E	Mitogen-activated Protein Kinase 15 (cluster #1 Of 1), Eukaryotic	Eukaryotes	2800	0.28	Binding ≤ 10μM
MKNK1-1-E	MAP Kinase-interacting Serine/threonine-protein Kinase MNK1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	4900	0.27	Binding ≤ 10μM
MKNK2-1-E	MAP Kinase Signal-integrating Kinase 2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	270	0.33	Binding ≤ 10μM
MUSK-1-E	Muscle, Skeletal Receptor Tyrosine Protein Kinase (cluster #1 Of 1), Eukaryotic	Eukaryotes	10	0.40	Binding ≤ 10μM
NTRK1-1-E	Nerve Growth Factor Receptor Trk-A (cluster #1 Of 1), Eukaryotic	Eukaryotes	3100	0.28	Binding ≤ 10μM
NTRK2-1-E	Neurotrophic Tyrosine Kinase Receptor Type 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1100	0.30	Binding ≤ 10μM
NTRK3-1-E	NT-3 Growth Factor Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	210	0.33	Binding ≤ 10μM
PGFRA-1-E	Platelet-derived Growth Factor Receptor Alpha (cluster #1 Of 2), Eukaryotic	Eukaryotes	4	0.42	Binding ≤ 10μM
PGFRB-1-E	Platelet-derived Growth Factor Receptor Beta (cluster #1 Of 1), Eukaryotic	Eukaryotes	66	0.36	Binding ≤ 10μM
PLK3-1-E	Serine/threonine-protein Kinase PLK3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	8500	0.25	Binding ≤ 10μM
RET-1-E	Tyrosine-protein Kinase Receptor RET (cluster #1 Of 1), Eukaryotic	Eukaryotes	1900	0.29	Binding ≤ 10μM
RIPK1-1-E	Receptor-interacting Serine/threonine-protein Kinase 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	2800	0.28	Binding ≤ 10μM
SLK-1-E	Serine/threonine-protein Kinase 2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	450	0.32	Binding ≤ 10μM
ST32B-1-E	Serine/threonine-protein Kinase 32B (cluster #1 Of 1), Eukaryotic	Eukaryotes	270	0.33	Binding ≤ 10μM
STK10-1-E	Serine/threonine-protein Kinase 10 (cluster #1 Of 1), Eukaryotic	Eukaryotes	460	0.32	Binding ≤ 10μM
STK3-1-E	Serine/threonine-protein Kinase MST2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	1500	0.29	Binding ≤ 10μM
STK33-1-E	Serine/threonine-protein Kinase 33 (cluster #1 Of 1), Eukaryotic	Eukaryotes	3800	0.27	Binding ≤ 10μM
STK4-2-E	Serine/threonine-protein Kinase MST1 (cluster #2 Of 2), Eukaryotic	Eukaryotes	1400	0.29	Binding ≤ 10μM
TIE1-1-E	Tyrosine-protein Kinase Receptor Tie-1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	110	0.35	Binding ≤ 10μM
TIE2-1-E	Tyrosine-protein Kinase TIE-2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	450	0.32	Binding ≤ 10μM
UFO-1-E	Tyrosine-protein Kinase Receptor UFO (cluster #1 Of 1), Eukaryotic	Eukaryotes	340	0.32	Binding ≤ 10μM
VGFR1-1-E	Vascular Endothelial Growth Factor Receptor 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	8	0.40	Binding ≤ 10μM
VGFR2-1-E	Vascular Endothelial Growth Factor Receptor 2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	8	0.40	Binding ≤ 10μM
VGFR3-1-E	Vascular Endothelial Growth Factor Receptor 3 (cluster #1 Of 2), Eukaryotic	Eukaryotes	190	0.34	Binding ≤ 10μM
VGFR2-2-E	Vascular Endothelial Growth Factor Receptor 2 (cluster #2 Of 2), Eukaryotic	Eukaryotes	4	0.42	Functional ≤ 10μM

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	4.73	7.88	-12.09	5	6	0	96	375.407	3	↓ MOL2 SDF SMILES Flexibase

3834198

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: Vandetanib Vandetanib

Find On: PubMed — Wikipedia — Google

Vendors

And 31 More

Activity (Go SEA)

Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
AAPK1-1-E	AMP-activated Protein Kinase, Alpha-1 Subunit (cluster #1 Of 1), Eukaryotic	Eukaryotes	10000	0.23	Binding ≤ 10μM
ABL1-1-E	Tyrosine-protein Kinase ABL (cluster #1 Of 1), Eukaryotic	Eukaryotes	94	0.33	Binding ≤ 10μM
ABL2-1-E	Tyrosine-protein Kinase ABL2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	69	0.33	Binding ≤ 10μM
ACVL1-1-E	Serine/threonine-protein Kinase Receptor R3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	470	0.30	Binding ≤ 10μM
ACVR1-1-E	Activin Receptor Type-1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	150	0.32	Binding ≤ 10μM
ADCK3-1-E	Chaperone Activity Of Bc1 Complex-like, Mitochondrial (cluster #1 Of 1), Eukaryotic	Eukaryotes	4500	0.25	Binding ≤ 10μM
ADCK4-1-E	Uncharacterized AarF Domain-containing Protein Kinase 4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1700	0.27	Binding ≤ 10μM
ALK-1-E	ALK Tyrosine Kinase Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	2100	0.26	Binding ≤ 10μM
AURKC-1-E	Serine/threonine-protein Kinase Aurora-C (cluster #1 Of 2), Eukaryotic	Eukaryotes	1500	0.27	Binding ≤ 10μM
BLK-1-E	Tyrosine-protein Kinase BLK (cluster #1 Of 1), Eukaryotic	Eukaryotes	66	0.34	Binding ≤ 10μM
CSF1R-1-E	Macrophage Colony-stimulating Factor 1 Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	1200	0.28	Binding ≤ 10μM
CSK-1-E	Tyrosine-protein Kinase CSK (cluster #1 Of 1), Eukaryotic	Eukaryotes	3700	0.25	Binding ≤ 10μM
CTRO-1-E	Citron Rho-interacting Kinase (cluster #1 Of 1), Eukaryotic	Eukaryotes	1800	0.27	Binding ≤ 10μM
DDR1-1-E	Epithelial Discoidin Domain-containing Receptor 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	11	0.37	Binding ≤ 10μM
DDR2-1-E	Discoidin Domain-containing Receptor 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	320	0.30	Binding ≤ 10μM
EGFR-3-E	Epidermal Growth Factor Receptor ErbB1 (cluster #3 Of 4), Eukaryotic	Eukaryotes	10	0.37	Binding ≤ 10μM
EGFR-3-E	Epidermal Growth Factor Receptor ErbB1 (cluster #3 Of 4), Eukaryotic	Eukaryotes	500	0.29	Binding ≤ 10μM
EPHA1-1-E	Ephrin Type-A Receptor 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	230	0.31	Binding ≤ 10μM
EPHA2-1-E	Ephrin Type-A Receptor 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1900	0.27	Binding ≤ 10μM
EPHA3-1-E	Ephrin Type-A Receptor 3 (cluster #1 Of 2), Eukaryotic	Eukaryotes	2000	0.27	Binding ≤ 10μM
EPHA4-1-E	Ephrin Type-A Receptor 4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	4300	0.25	Binding ≤ 10μM
EPHA5-1-E	Ephrin Type-A Receptor 5 (cluster #1 Of 1), Eukaryotic	Eukaryotes	310	0.30	Binding ≤ 10μM
EPHA6-1-E	Ephrin Type-A Receptor 6 (cluster #1 Of 1), Eukaryotic	Eukaryotes	65	0.34	Binding ≤ 10μM
EPHA7-1-E	Ephrin Type-A Receptor 7 (cluster #1 Of 1), Eukaryotic	Eukaryotes	3400	0.26	Binding ≤ 10μM
EPHA8-1-E	Ephrin Type-A Receptor 8 (cluster #1 Of 1), Eukaryotic	Eukaryotes	91	0.33	Binding ≤ 10μM
EPHB1-1-E	Ephrin Type-B Receptor 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	540	0.29	Binding ≤ 10μM
EPHB2-1-E	Ephrin Type-B Receptor 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	440	0.30	Binding ≤ 10μM
EPHB4-1-E	Ephrin Type-B Receptor 4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	520	0.29	Binding ≤ 10μM
ERBB2-2-E	Receptor Protein-tyrosine Kinase ErbB-2 (cluster #2 Of 3), Eukaryotic	Eukaryotes	2600	0.26	Binding ≤ 10μM
FGFR1-1-E	Fibroblast Growth Factor Receptor 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	560	0.29	Binding ≤ 10μM
FGFR1-1-E	Fibroblast Growth Factor Receptor 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	3600	0.25	Binding ≤ 10μM
FGFR2-1-E	Fibroblast Growth Factor Receptor 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	5500	0.25	Binding ≤ 10μM
FGFR3-1-E	Fibroblast Growth Factor Receptor 3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	6900	0.24	Binding ≤ 10μM
FGR-1-E	Tyrosine-protein Kinase FGR (cluster #1 Of 2), Eukaryotic	Eukaryotes	270	0.31	Binding ≤ 10μM
FLT3-1-E	Tyrosine-protein Kinase Receptor FLT3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	850	0.28	Binding ≤ 10μM
FRK-1-E	Tyrosine-protein Kinase FRK (cluster #1 Of 1), Eukaryotic	Eukaryotes	480	0.29	Binding ≤ 10μM
FYN-1-E	Tyrosine-protein Kinase FYN (cluster #1 Of 5), Eukaryotic	Eukaryotes	5700	0.24	Binding ≤ 10μM
GAK-1-E	Serine/threonine-protein Kinase GAK (cluster #1 Of 2), Eukaryotic	Eukaryotes	86	0.33	Binding ≤ 10μM
HCK-1-E	Tyrosine-protein Kinase HCK (cluster #1 Of 1), Eukaryotic	Eukaryotes	4200	0.25	Binding ≤ 10μM
KC1E-1-E	Casein Kinase I Epsilon (cluster #1 Of 2), Eukaryotic	Eukaryotes	3000	0.26	Binding ≤ 10μM
KIT-1-E	Stem Cell Growth Factor Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	560	0.29	Binding ≤ 10μM
KS6A1-1-E	Ribosomal Protein S6 Kinase Alpha 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	400	0.30	Binding ≤ 10μM
KS6A6-1-E	Ribosomal Protein S6 Kinase Alpha 6 (cluster #1 Of 1), Eukaryotic	Eukaryotes	240	0.31	Binding ≤ 10μM
LCK-1-E	Tyrosine-protein Kinase LCK (cluster #1 Of 4), Eukaryotic	Eukaryotes	61	0.34	Binding ≤ 10μM
LTK-1-E	Leukocyte Tyrosine Kinase Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	550	0.29	Binding ≤ 10μM
LYN-1-E	Tyrosine-protein Kinase Lyn (cluster #1 Of 1), Eukaryotic	Eukaryotes	710	0.29	Binding ≤ 10μM
M3K4-1-E	Mitogen-activated Protein Kinase Kinase Kinase 4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	4800	0.25	Binding ≤ 10μM
M4K3-1-E	Mitogen-activated Protein Kinase Kinase Kinase Kinase 3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1500	0.27	Binding ≤ 10μM
M4K4-2-E	Mitogen-activated Protein Kinase Kinase Kinase Kinase 4 (cluster #2 Of 2), Eukaryotic	Eukaryotes	1400	0.27	Binding ≤ 10μM
M4K5-1-E	Mitogen-activated Protein Kinase Kinase Kinase Kinase 5 (cluster #1 Of 1), Eukaryotic	Eukaryotes	510	0.29	Binding ≤ 10μM
MERTK-1-E	Proto-oncogene Tyrosine-protein Kinase MER (cluster #1 Of 1), Eukaryotic	Eukaryotes	1400	0.27	Binding ≤ 10μM
MET-1-E	Hepatocyte Growth Factor Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	5700	0.24	Binding ≤ 10μM
MK06-1-E	Mitogen-activated Protein Kinase 6 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1500	0.27	Binding ≤ 10μM
MKNK1-1-E	MAP Kinase-interacting Serine/threonine-protein Kinase MNK1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	360	0.30	Binding ≤ 10μM
MKNK2-1-E	MAP Kinase Signal-integrating Kinase 2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	3400	0.26	Binding ≤ 10μM
MLTK-1-E	Mixed Lineage Kinase 7 (cluster #1 Of 1), Eukaryotic	Eukaryotes	5100	0.25	Binding ≤ 10μM
MP2K1-3-E	Dual Specificity Mitogen-activated Protein Kinase Kinase 1 (cluster #3 Of 4), Eukaryotic	Eukaryotes	1800	0.27	Binding ≤ 10μM
MP2K2-1-E	Dual Specificity Mitogen-activated Protein Kinase Kinase 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1100	0.28	Binding ≤ 10μM
MRCKA-1-E	Serine/threonine-protein Kinase MRCK-A (cluster #1 Of 1), Eukaryotic	Eukaryotes	2600	0.26	Binding ≤ 10μM
MRCKB-1-E	Serine/threonine-protein Kinase MRCK Beta (cluster #1 Of 1), Eukaryotic	Eukaryotes	2500	0.26	Binding ≤ 10μM
MRCKG-1-E	Serine/threonine-protein Kinase MRCK Gamma (cluster #1 Of 1), Eukaryotic	Eukaryotes	2200	0.26	Binding ≤ 10μM
PGFRA-2-E	Platelet-derived Growth Factor Receptor Alpha (cluster #2 Of 2), Eukaryotic	Eukaryotes	230	0.31	Binding ≤ 10μM
PGFRB-1-E	Platelet-derived Growth Factor Receptor Beta (cluster #1 Of 1), Eukaryotic	Eukaryotes	88	0.33	Binding ≤ 10μM
PGFRB-1-E	Platelet-derived Growth Factor Receptor Beta (cluster #1 Of 1), Eukaryotic	Eukaryotes	1100	0.28	Binding ≤ 10μM
PHKG1-1-E	Phosphorylase Kinase Gamma Subunit 1 (cluster #1 Of 2), Eukaryotic	Eukaryotes	7100	0.24	Binding ≤ 10μM
PHKG2-1-E	Phosphorylase Kinase Gamma Subunit 2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	9500	0.23	Binding ≤ 10μM
PLK4-1-E	Serine/threonine-protein Kinase PLK4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	620	0.29	Binding ≤ 10μM
PTK6-1-E	Tyrosine-protein Kinase BRK (cluster #1 Of 1), Eukaryotic	Eukaryotes	33	0.35	Binding ≤ 10μM
RET-1-E	Tyrosine-protein Kinase Receptor RET (cluster #1 Of 1), Eukaryotic	Eukaryotes	97	0.33	Binding ≤ 10μM
RIPK2-1-E	Serine/threonine-protein Kinase RIPK2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	5	0.39	Binding ≤ 10μM
SIK1-1-E	Serine/threonine-protein Kinase SIK1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1900	0.27	Binding ≤ 10μM
SIK2-1-E	Serine/threonine-protein Kinase SIK2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	430	0.30	Binding ≤ 10μM
SLK-1-E	Serine/threonine-protein Kinase 2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	96	0.33	Binding ≤ 10μM
SRC-1-E	Tyrosine-protein Kinase SRC (cluster #1 Of 3), Eukaryotic	Eukaryotes	70	0.33	Binding ≤ 10μM
SRMS-1-E	Tyrosine-protein Kinase Srms (cluster #1 Of 1), Eukaryotic	Eukaryotes	1900	0.27	Binding ≤ 10μM
STK10-1-E	Serine/threonine-protein Kinase 10 (cluster #1 Of 1), Eukaryotic	Eukaryotes	81	0.33	Binding ≤ 10μM
STK33-1-E	Serine/threonine-protein Kinase 33 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1400	0.27	Binding ≤ 10μM
TBA1A-1-E	Tubulin Alpha-3 Chain (cluster #1 Of 3), Eukaryotic	Eukaryotes	480	0.29	Binding ≤ 10μM
TESK1-1-E	Dual Specificity Testis-specific Protein Kinase 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	3700	0.25	Binding ≤ 10μM
TIE1-1-E	Tyrosine-protein Kinase Receptor Tie-1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1500	0.27	Binding ≤ 10μM
TIE2-1-E	Tyrosine-protein Kinase TIE-2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	2500	0.26	Binding ≤ 10μM
TIE2-1-E	Tyrosine-protein Kinase TIE-2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	3600	0.25	Binding ≤ 10μM
TNI3K-1-E	Serine/threonine-protein Kinase TNNI3K (cluster #1 Of 1), Eukaryotic	Eukaryotes	2800	0.26	Binding ≤ 10μM
TNIK-1-E	TRAF2- And NCK-interacting Kinase (cluster #1 Of 2), Eukaryotic	Eukaryotes	3900	0.25	Binding ≤ 10μM
TXK-1-E	Tyrosine-protein Kinase TXK (cluster #1 Of 1), Eukaryotic	Eukaryotes	3700	0.25	Binding ≤ 10μM
TYRO3-1-E	Tyrosine-protein Kinase Receptor TYRO3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	93	0.33	Binding ≤ 10μM
UFO-1-E	Tyrosine-protein Kinase Receptor UFO (cluster #1 Of 1), Eukaryotic	Eukaryotes	250	0.31	Binding ≤ 10μM
VGFR1-1-E	Vascular Endothelial Growth Factor Receptor 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	260	0.31	Binding ≤ 10μM
VGFR1-1-E	Vascular Endothelial Growth Factor Receptor 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1600	0.27	Binding ≤ 10μM
VGFR2-1-E	Vascular Endothelial Growth Factor Receptor 2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	9	0.38	Binding ≤ 10μM
VGFR2-1-E	Vascular Endothelial Growth Factor Receptor 2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	40	0.35	Binding ≤ 10μM
VGFR3-1-E	Vascular Endothelial Growth Factor Receptor 3 (cluster #1 Of 2), Eukaryotic	Eukaryotes	300	0.30	Binding ≤ 10μM
YES-1-E	Tyrosine-protein Kinase YES (cluster #1 Of 1), Eukaryotic	Eukaryotes	280	0.31	Binding ≤ 10μM
EGFR-1-E	Epidermal Growth Factor Receptor ErbB1 (cluster #1 Of 2), Eukaryotic	Eukaryotes	170	0.32	Functional ≤ 10μM
FGFR1-1-E	Fibroblast Growth Factor Receptor 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1200	0.28	Functional ≤ 10μM
FGFR2-1-E	Fibroblast Growth Factor Receptor 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1200	0.28	Functional ≤ 10μM
FGFR3-1-E	Fibroblast Growth Factor Receptor 3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1200	0.28	Functional ≤ 10μM
VGFR1-1-E	Vascular Endothelial Growth Factor Receptor 1 (cluster #1 Of 2), Eukaryotic	Eukaryotes	60	0.34	Functional ≤ 10μM
VGFR1-1-E	Vascular Endothelial Growth Factor Receptor 1 (cluster #1 Of 2), Eukaryotic	Eukaryotes	400	0.30	Functional ≤ 10μM
VGFR2-1-E	Vascular Endothelial Growth Factor Receptor 2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	60	0.34	Functional ≤ 10μM
VGFR2-1-E	Vascular Endothelial Growth Factor Receptor 2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	400	0.30	Functional ≤ 10μM
VGFR3-1-E	Vascular Endothelial Growth Factor Receptor 3 (cluster #1 Of 2), Eukaryotic	Eukaryotes	60	0.34	Functional ≤ 10μM
VGFR3-1-E	Vascular Endothelial Growth Factor Receptor 3 (cluster #1 Of 2), Eukaryotic	Eukaryotes	400	0.30	Functional ≤ 10μM
Z100768-1-O	TPC1 (Papillary Thyroid Carinoma Cells) (cluster #1 Of 1), Other	Other	116	0.32	Functional ≤ 10μM
Z80166-1-O	HT-29 (Colon Adenocarcinoma Cells) (cluster #1 Of 12), Other	Other	4200	0.25	Functional ≤ 10μM
Z81057-1-O	HUVEC (Umbilical Vein Endothelial Cells) (cluster #1 Of 4), Other	Other	60	0.34	Functional ≤ 10μM
Z81057-1-O	HUVEC (Umbilical Vein Endothelial Cells) (cluster #1 Of 4), Other	Other	400	0.30	Functional ≤ 10μM

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	4.98	13.02	-39.96	2	6	1	61	476.37	6	↓ MOL2 SDF SMILES Flexibase

12410091

Analogs

3834201

Draw Identity 99% 90% 80% 70%

Popular Name: SU-5416 SU-5416

Find On: PubMed — Wikipedia — Google

Vendors

And 2 More

Activity (Go SEA)

Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
ALK-1-E	ALK Tyrosine Kinase Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	1200	0.46	Binding ≤ 10μM
CSF1R-1-E	Macrophage Colony-stimulating Factor 1 Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	84	0.55	Binding ≤ 10μM
FGFR1-1-E	Fibroblast Growth Factor Receptor 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	7080	0.40	Binding ≤ 10μM
FLT3-1-E	Tyrosine-protein Kinase Receptor FLT3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	160	0.53	Binding ≤ 10μM
KIT-1-E	Stem Cell Growth Factor Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	660	0.48	Binding ≤ 10μM
PGFRB-1-E	Platelet-derived Growth Factor Receptor Beta (cluster #1 Of 1), Eukaryotic	Eukaryotes	680	0.48	Binding ≤ 10μM
RET-1-E	Tyrosine-protein Kinase Receptor RET (cluster #1 Of 1), Eukaryotic	Eukaryotes	170	0.53	Binding ≤ 10μM
VGFR1-1-E	Vascular Endothelial Growth Factor Receptor 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1040	0.47	Binding ≤ 10μM
VGFR2-1-E	Vascular Endothelial Growth Factor Receptor 2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	884	0.47	Binding ≤ 10μM
VGFR3-1-E	Vascular Endothelial Growth Factor Receptor 3 (cluster #1 Of 2), Eukaryotic	Eukaryotes	50	0.57	Binding ≤ 10μM
PGFRA-1-E	Platelet-derived Growth Factor Receptor Alpha (cluster #1 Of 1), Eukaryotic	Eukaryotes	4050	0.42	Functional ≤ 10μM
PGFRB-1-E	Platelet-derived Growth Factor Receptor Beta (cluster #1 Of 1), Eukaryotic	Eukaryotes	4540	0.42	Functional ≤ 10μM
VGFR2-1-E	Vascular Endothelial Growth Factor Receptor 2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	40	0.58	Functional ≤ 10μM
Z100081-1-O	PBMC (Peripheral Blood Mononuclear Cells) (cluster #1 Of 4), Other	Other	5	0.65	Functional ≤ 10μM
Z103205-1-O	A431 (cluster #1 Of 4), Other	Other	85	0.55	Functional ≤ 10μM
Z50425-3-O	Plasmodium Falciparum (cluster #3 Of 22), Other	Other	7943	0.40	Functional ≤ 10μM
Z50501-1-O	Gallus Gallus (cluster #1 Of 3), Other	Other	85	0.55	Functional ≤ 10μM
Z81057-1-O	HUVEC (Umbilical Vein Endothelial Cells) (cluster #1 Of 4), Other	Other	4540	0.42	Functional ≤ 10μM

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	2.88	6.69	-8.41	2	3	0	49	238.29	1	↓ MOL2 SDF SMILES Flexibase

22448983

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: SKI-606 SKI-606

Find On: PubMed — Wikipedia — Google

Vendors

Activity (Go SEA)

Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
ABL1-1-E	Tyrosine-protein Kinase ABL (cluster #1 Of 1), Eukaryotic	Eukaryotes	20	0.30	Binding ≤ 10μM
ABL2-1-E	Tyrosine-protein Kinase ABL2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1	0.35	Binding ≤ 10μM
ACK1-1-E	Tyrosine Kinase Non-receptor Protein 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	3	0.33	Binding ≤ 10μM
ALK-1-E	ALK Tyrosine Kinase Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	200	0.26	Binding ≤ 10μM
BCR-1-E	Breakpoint Cluster Region Protein (cluster #1 Of 1), Eukaryotic	Eukaryotes	20	0.30	Binding ≤ 10μM
BLK-1-E	Tyrosine-protein Kinase BLK (cluster #1 Of 1), Eukaryotic	Eukaryotes	7	0.32	Binding ≤ 10μM
BMX-1-E	Tyrosine-protein Kinase BMX (cluster #1 Of 1), Eukaryotic	Eukaryotes	8	0.31	Binding ≤ 10μM
BTK-1-E	Tyrosine-protein Kinase BTK (cluster #1 Of 1), Eukaryotic	Eukaryotes	3	0.33	Binding ≤ 10μM
CSK-1-E	Tyrosine-protein Kinase CSK (cluster #1 Of 1), Eukaryotic	Eukaryotes	63	0.28	Binding ≤ 10μM
EGFR-1-E	Epidermal Growth Factor Receptor ErbB1 (cluster #1 Of 4), Eukaryotic	Eukaryotes	53	0.28	Binding ≤ 10μM
EPHB2-1-E	Ephrin Type-B Receptor 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	9	0.31	Binding ≤ 10μM
EPHB4-1-E	Ephrin Type-B Receptor 4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	6	0.32	Binding ≤ 10μM
FAK1-1-E	Focal Adhesion Kinase 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	538	0.24	Binding ≤ 10μM
FAK2-1-E	Protein-tyrosine Kinase 2-beta (cluster #1 Of 1), Eukaryotic	Eukaryotes	134	0.27	Binding ≤ 10μM
FER-1-E	Tyrosine-protein Kinase FER (cluster #1 Of 1), Eukaryotic	Eukaryotes	490	0.25	Binding ≤ 10μM
FES-1-E	Tyrosine-protein Kinase FES (cluster #1 Of 1), Eukaryotic	Eukaryotes	358	0.25	Binding ≤ 10μM
FGR-1-E	Tyrosine-protein Kinase FGR (cluster #1 Of 2), Eukaryotic	Eukaryotes	1	0.35	Binding ≤ 10μM
FRK-1-E	Tyrosine-protein Kinase FRK (cluster #1 Of 1), Eukaryotic	Eukaryotes	2	0.34	Binding ≤ 10μM
FYN-1-E	Tyrosine-protein Kinase FYN (cluster #1 Of 5), Eukaryotic	Eukaryotes	2	0.34	Binding ≤ 10μM
HCK-1-E	Tyrosine-protein Kinase HCK (cluster #1 Of 1), Eukaryotic	Eukaryotes	3	0.33	Binding ≤ 10μM
IRAK4-1-E	Interleukin-1 Receptor-associated Kinase 4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	574	0.24	Binding ≤ 10μM
KCC1D-1-E	CaM Kinase I Delta (cluster #1 Of 2), Eukaryotic	Eukaryotes	92	0.27	Binding ≤ 10μM
KCC2G-1-E	CaM Kinase II Gamma (cluster #1 Of 1), Eukaryotic	Eukaryotes	184	0.26	Binding ≤ 10μM
KIT-1-E	Stem Cell Growth Factor Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	6313	0.20	Binding ≤ 10μM
KSYK-1-E	Tyrosine-protein Kinase SYK (cluster #1 Of 2), Eukaryotic	Eukaryotes	52	0.28	Binding ≤ 10μM
LCK-1-E	Tyrosine-protein Kinase LCK (cluster #1 Of 4), Eukaryotic	Eukaryotes	1	0.35	Binding ≤ 10μM
LYN-1-E	Tyrosine-protein Kinase Lyn (cluster #1 Of 1), Eukaryotic	Eukaryotes	8	0.31	Binding ≤ 10μM
M4K2-1-E	Mitogen-activated Protein Kinase Kinase Kinase Kinase 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	10	0.31	Binding ≤ 10μM
M4K5-1-E	Mitogen-activated Protein Kinase Kinase Kinase Kinase 5 (cluster #1 Of 1), Eukaryotic	Eukaryotes	0	0.00	Binding ≤ 10μM
MINK1-1-E	Misshapen-like Kinase 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	22	0.30	Binding ≤ 10μM
NPM-1-E	Nucleophosmin (cluster #1 Of 1), Eukaryotic	Eukaryotes	200	0.26	Binding ≤ 10μM
NTRK1-1-E	Nerve Growth Factor Receptor Trk-A (cluster #1 Of 1), Eukaryotic	Eukaryotes	22	0.30	Binding ≤ 10μM
NTRK2-1-E	Neurotrophic Tyrosine Kinase Receptor Type 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	27	0.29	Binding ≤ 10μM
SRC-1-E	Tyrosine-protein Kinase SRC (cluster #1 Of 3), Eukaryotic	Eukaryotes	4	0.33	Binding ≤ 10μM
STK10-1-E	Serine/threonine-protein Kinase 10 (cluster #1 Of 1), Eukaryotic	Eukaryotes	52	0.28	Binding ≤ 10μM
STK24-1-E	Serine/threonine-protein Kinase 24 (cluster #1 Of 1), Eukaryotic	Eukaryotes	4	0.33	Binding ≤ 10μM
STK4-1-E	Serine/threonine-protein Kinase MST1 (cluster #1 Of 2), Eukaryotic	Eukaryotes	191	0.26	Binding ≤ 10μM
TBK1-1-E	Serine/threonine-protein Kinase TBK1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	471	0.25	Binding ≤ 10μM
TEC-1-E	Tyrosine-protein Kinase TEC (cluster #1 Of 1), Eukaryotic	Eukaryotes	282	0.25	Binding ≤ 10μM
TIE2-1-E	Tyrosine-protein Kinase TIE-2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	1191	0.23	Binding ≤ 10μM
TXK-1-E	Tyrosine-protein Kinase TXK (cluster #1 Of 1), Eukaryotic	Eukaryotes	40	0.29	Binding ≤ 10μM
UFO-1-E	Tyrosine-protein Kinase Receptor UFO (cluster #1 Of 1), Eukaryotic	Eukaryotes	174	0.26	Binding ≤ 10μM
YES-1-E	Tyrosine-protein Kinase YES (cluster #1 Of 1), Eukaryotic	Eukaryotes	0	0.00	Binding ≤ 10μM
ABL1-1-E	Tyrosine-protein Kinase ABL (cluster #1 Of 2), Eukaryotic	Eukaryotes	490	0.25	Functional ≤ 10μM
ABL2-1-E	Tyrosine-protein Kinase ABL2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1	0.35	Functional ≤ 10μM
ERBB2-2-E	Receptor Protein-tyrosine Kinase ErbB-2 (cluster #2 Of 3), Eukaryotic	Eukaryotes	2600	0.22	Functional ≤ 10μM
FYN-1-E	Tyrosine-protein Kinase FYN (cluster #1 Of 1), Eukaryotic	Eukaryotes	410	0.25	Functional ≤ 10μM
PGFRA-1-E	Platelet-derived Growth Factor Receptor Alpha (cluster #1 Of 1), Eukaryotic	Eukaryotes	4000	0.21	Functional ≤ 10μM
PGFRB-1-E	Platelet-derived Growth Factor Receptor Beta (cluster #1 Of 1), Eukaryotic	Eukaryotes	4000	0.21	Functional ≤ 10μM
SRC-1-E	Tyrosine-protein Kinase SRC (cluster #1 Of 1), Eukaryotic	Eukaryotes	100	0.27	Functional ≤ 10μM
Z50597-1-O	Rattus Norvegicus (cluster #1 Of 12), Other	Other	100	0.27	Functional ≤ 10μM
Z80036-2-O	BaF3 (IL-3-dependent Pro-B-cells) (cluster #2 Of 3), Other	Other	200	0.26	Functional ≤ 10μM
Z80166-1-O	HT-29 (Colon Adenocarcinoma Cells) (cluster #1 Of 12), Other	Other	5000	0.21	Functional ≤ 10μM
Z80186-6-O	K562 (Erythroleukemia Cells) (cluster #6 Of 11), Other	Other	20	0.30	Functional ≤ 10μM
Z80416-1-O	Rat1 (Fibroblast Cells) (cluster #1 Of 1), Other	Other	490	0.25	Functional ≤ 10μM
Z81020-7-O	HepG2 (Hepatoblastoma Cells) (cluster #7 Of 8), Other	Other	3910	0.21	Functional ≤ 10μM
Z81125-1-O	KU812 Cell Line (cluster #1 Of 1), Other	Other	5	0.32	Functional ≤ 10μM
Z81328-1-O	Src-transformed (Fibroblast Cells) (cluster #1 Of 1), Other	Other	100	0.27	Functional ≤ 10μM
ABL-1-V	Tyrosine-protein Kinase V-ABL (cluster #1 Of 1), Viral	Viruses	1	0.35	Binding ≤ 10μM

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	4.98	9.49	-44.8	2	8	1	84	531.464	9	↓ MOL2 SDF SMILES Flexibase
Hi High (pH 8-9.5)	4.98	7.02	-12.44	1	8	0	83	530.456	9	↓ MOL2 SDF SMILES Flexibase
Mid Mid (pH 6-8)	4.98	9.35	-46.97	2	8	1	84	531.464	9	↓ MOL2 SDF SMILES Flexibase

22935274

Analogs

Draw Identity 99% 90% 80% 70%

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Vendors

American Custom Chemicals Corp.
- CHM0292966

Activity (Go SEA)

Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
ALK-1-E	ALK Tyrosine Kinase Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	900	0.26	Binding ≤ 10μM
INSR-1-E	Insulin Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	5300	0.22	Binding ≤ 10μM
Z81072-1-O	Jurkat (Acute Leukemic T-cells) (cluster #1 Of 10), Other	Other	9200	0.21	Functional ≤ 10μM

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	2.73	7.44	-51.26	3	8	1	88	447.515	5	↓ MOL2 SDF SMILES Flexibase
Mid Mid (pH 6-8)	2.73	7.31	-48.8	3	8	1	88	447.515	5	↓ MOL2 SDF SMILES Flexibase
Mid Mid (pH 6-8)	2.73	4.97	-19.51	2	8	0	87	446.507	5	↓ MOL2 SDF SMILES Flexibase

4302693

Analogs

33384040

Draw Identity 99% 90% 80% 70%

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Vendors

Activity (Go SEA)

Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
ALK-1-E	ALK Tyrosine Kinase Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	1	0.66	Binding ≤ 10μM

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	2.24	-1.33	-10.36	2	4	0	61	253.305	2	↓ MOL2 SDF SMILES Flexibase

2047743

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: PD173955 PD173955

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Vendors

And 1 More

Activity (Go SEA)

Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
ABL1-1-E	Tyrosine-protein Kinase ABL (cluster #1 Of 1), Eukaryotic	Eukaryotes	2	0.42	Binding ≤ 10μM
ALK-1-E	ALK Tyrosine Kinase Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	3000	0.27	Binding ≤ 10μM
BCR-1-E	Breakpoint Cluster Region Protein (cluster #1 Of 1), Eukaryotic	Eukaryotes	2	0.42	Binding ≤ 10μM
FGFR1-1-E	Fibroblast Growth Factor Receptor 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1250	0.28	Binding ≤ 10μM
LCK-1-E	Tyrosine-protein Kinase LCK (cluster #1 Of 4), Eukaryotic	Eukaryotes	5	0.40	Binding ≤ 10μM
NPM-1-E	Nucleophosmin (cluster #1 Of 1), Eukaryotic	Eukaryotes	3000	0.27	Binding ≤ 10μM
PGFRA-1-E	Platelet-derived Growth Factor Receptor Alpha (cluster #1 Of 2), Eukaryotic	Eukaryotes	1660	0.28	Binding ≤ 10μM
PGFRB-1-E	Platelet-derived Growth Factor Receptor Beta (cluster #1 Of 1), Eukaryotic	Eukaryotes	1660	0.28	Binding ≤ 10μM
SRC-1-E	Tyrosine-protein Kinase SRC (cluster #1 Of 3), Eukaryotic	Eukaryotes	25	0.37	Binding ≤ 10μM
Z80036-1-O	BaF3 (IL-3-dependent Pro-B-cells) (cluster #1 Of 3), Other	Other	2000	0.28	Functional ≤ 10μM
Z80152-1-O	HCT-8 (Ileocecal Adenocarcinoma) (cluster #1 Of 2), Other	Other	2520	0.27	Functional ≤ 10μM
Z80166-1-O	HT-29 (Colon Adenocarcinoma Cells) (cluster #1 Of 12), Other	Other	810	0.29	Functional ≤ 10μM
Z81331-1-O	SW-620 (Colon Adenocarcinoma Cells) (cluster #1 Of 6), Other	Other	980	0.29	Functional ≤ 10μM

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	5.71	14.64	-13.18	1	5	0	60	443.359	4	↓ MOL2 SDF SMILES Flexibase

9851

Analogs

116934
3815316

Draw Identity 99% 90% 80% 70%

Popular Name: Janex 1 Janex 1

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Vendors

Activity (Go SEA)

Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
ALK-1-E	ALK Tyrosine Kinase Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	2	0.55	Binding ≤ 10μM
EGFR-3-E	Epidermal Growth Factor Receptor ErbB1 (cluster #3 Of 4), Eukaryotic	Eukaryotes	100	0.45	Binding ≤ 10μM
LCK-1-E	Tyrosine-protein Kinase LCK (cluster #1 Of 4), Eukaryotic	Eukaryotes	3000	0.35	Binding ≤ 10μM
Z81137-2-O	L929 (Fibroblast Cells) (cluster #2 Of 2), Other	Other	1700	0.37	Functional ≤ 10μM

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	2.80	-1.4	-11.31	2	6	0	76	297.314	4	↓ MOL2 SDF SMILES Flexibase

21288966

Analogs

29416077
18825325

Draw Identity 99% 90% 80% 70%

Popular Name: Flavopiridol Flavopiridol

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Vendors

And 5 More

Activity (Go SEA)

Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
AAK1-1-E	Adaptor-associated Kinase (cluster #1 Of 2), Eukaryotic	Eukaryotes	5300	0.26	Binding ≤ 10μM
AAPK1-1-E	AMP-activated Protein Kinase, Alpha-1 Subunit (cluster #1 Of 1), Eukaryotic	Eukaryotes	6600	0.26	Binding ≤ 10μM
ACVR1-1-E	Activin Receptor Type-1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1900	0.29	Binding ≤ 10μM
ALK-1-E	ALK Tyrosine Kinase Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	670	0.31	Binding ≤ 10μM
AVR2B-1-E	Activin Receptor Type-2B (cluster #1 Of 1), Eukaryotic	Eukaryotes	2400	0.28	Binding ≤ 10μM
CCNA1-1-E	Cyclin A1 (cluster #1 Of 3), Eukaryotic	Eukaryotes	70	0.36	Binding ≤ 10μM
CCNA2-1-E	Cyclin A2 (cluster #1 Of 3), Eukaryotic	Eukaryotes	70	0.36	Binding ≤ 10μM
CCNB-1-E	G2/mitotic-specific Cyclin B (cluster #1 Of 1), Eukaryotic	Eukaryotes	400	0.32	Binding ≤ 10μM
CCNB1-1-E	G2/mitotic-specific Cyclin B1 (cluster #1 Of 2), Eukaryotic	Eukaryotes	520	0.31	Binding ≤ 10μM
CCNB2-1-E	G2/mitotic-specific Cyclin B2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	520	0.31	Binding ≤ 10μM
CCNB3-1-E	G2/mitotic-specific Cyclin B3 (cluster #1 Of 2), Eukaryotic	Eukaryotes	520	0.31	Binding ≤ 10μM
CCND1-1-E	G1/S-specific Cyclin D1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	100	0.35	Binding ≤ 10μM
CCND2-1-E	G1/S-specific Cyclin D2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	100	0.35	Binding ≤ 10μM
CCND3-1-E	G1/S-specific Cyclin D3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	100	0.35	Binding ≤ 10μM
CCNE1-1-E	G1/S-specific Cyclin E1 (cluster #1 Of 2), Eukaryotic	Eukaryotes	960	0.30	Binding ≤ 10μM
CCNE2-1-E	G1/S-specific Cyclin E2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	960	0.30	Binding ≤ 10μM
CCNH-1-E	Cyclin H (cluster #1 Of 1), Eukaryotic	Eukaryotes	400	0.32	Binding ≤ 10μM
CDK1-1-E	Cyclin-dependent Kinase 1 (cluster #1 Of 4), Eukaryotic	Eukaryotes	520	0.31	Binding ≤ 10μM
CDK14-1-E	Serine/threonine-protein Kinase PFTAIRE-1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	110	0.35	Binding ≤ 10μM
CDK16-1-E	Serine/threonine-protein Kinase PCTAIRE-1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	440	0.32	Binding ≤ 10μM
CDK17-1-E	Serine/threonine-protein Kinase PCTAIRE-2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	480	0.32	Binding ≤ 10μM
CDK18-1-E	Serine/threonine-protein Kinase PCTAIRE-3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1100	0.30	Binding ≤ 10μM
CDK19-1-E	Cell Division Cycle 2-like Protein Kinase 6 (cluster #1 Of 1), Eukaryotic	Eukaryotes	57	0.36	Binding ≤ 10μM
CDK2-1-E	Cyclin-dependent Kinase 2 (cluster #1 Of 5), Eukaryotic	Eukaryotes	960	0.30	Binding ≤ 10μM
CDK3-1-E	Cyclin-dependent Kinase 3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	410	0.32	Binding ≤ 10μM
CDK4-2-E	Cyclin-dependent Kinase 4 (cluster #2 Of 3), Eukaryotic	Eukaryotes	100	0.35	Binding ≤ 10μM
CDK5-1-E	Cyclin-dependent Kinase 5 (cluster #1 Of 1), Eukaryotic	Eukaryotes	43	0.37	Binding ≤ 10μM
CDK6-1-E	Cyclin-dependent Kinase 6 (cluster #1 Of 1), Eukaryotic	Eukaryotes	80	0.35	Binding ≤ 10μM
CDK7-1-E	Cyclin-dependent Kinase 7 (cluster #1 Of 1), Eukaryotic	Eukaryotes	875	0.30	Binding ≤ 10μM
CDK8-1-E	Cell Division Protein Kinase 8 (cluster #1 Of 1), Eukaryotic	Eukaryotes	120	0.35	Binding ≤ 10μM
CDK9-1-E	Cyclin-dependent Kinase 9 (cluster #1 Of 2), Eukaryotic	Eukaryotes	6	0.41	Binding ≤ 10μM
CLK1-1-E	Dual Specificty Protein Kinase CLK1 (cluster #1 Of 2), Eukaryotic	Eukaryotes	2200	0.28	Binding ≤ 10μM
CLK2-1-E	Dual Specificity Protein Kinase CLK2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	2200	0.28	Binding ≤ 10μM
CLK3-1-E	Dual Specificity Protein Kinase CLK3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1600	0.29	Binding ≤ 10μM
CSF1R-1-E	Macrophage Colony-stimulating Factor 1 Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	2800	0.28	Binding ≤ 10μM
CTRO-1-E	Citron Rho-interacting Kinase (cluster #1 Of 1), Eukaryotic	Eukaryotes	110	0.35	Binding ≤ 10μM
DCLK1-1-E	Serine/threonine-protein Kinase DCLK1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	2100	0.28	Binding ≤ 10μM
DCLK3-1-E	Serine/threonine-protein Kinase DCLK3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1100	0.30	Binding ≤ 10μM
DMPK-1-E	Myotonin-protein Kinase (cluster #1 Of 1), Eukaryotic	Eukaryotes	650	0.31	Binding ≤ 10μM
DYR1B-1-E	Dual Specificity Tyrosine-phosphorylation-regulated Kinase 1B (cluster #1 Of 1), Eukaryotic	Eukaryotes	84	0.35	Binding ≤ 10μM
E2AK2-1-E	Interferon-induced, Double-stranded RNA-activated Protein Kinase (cluster #1 Of 1), Eukaryotic	Eukaryotes	5200	0.26	Binding ≤ 10μM
EGFR-2-E	Epidermal Growth Factor Receptor ErbB1 (cluster #2 Of 4), Eukaryotic	Eukaryotes	7600	0.26	Binding ≤ 10μM
EPHA2-1-E	Ephrin Type-A Receptor 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	2500	0.28	Binding ≤ 10μM
EPHA3-1-E	Ephrin Type-A Receptor 3 (cluster #1 Of 2), Eukaryotic	Eukaryotes	3300	0.27	Binding ≤ 10μM
EPHA5-1-E	Ephrin Type-A Receptor 5 (cluster #1 Of 1), Eukaryotic	Eukaryotes	4000	0.27	Binding ≤ 10μM
EPHB1-1-E	Ephrin Type-B Receptor 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	2200	0.28	Binding ≤ 10μM
FLT3-1-E	Tyrosine-protein Kinase Receptor FLT3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	6500	0.26	Binding ≤ 10μM
GAK-1-E	Serine/threonine-protein Kinase GAK (cluster #1 Of 2), Eukaryotic	Eukaryotes	370	0.32	Binding ≤ 10μM
GSK3A-1-E	Glycogen Synthase Kinase-3 Alpha (cluster #1 Of 3), Eukaryotic	Eukaryotes	1300	0.29	Binding ≤ 10μM
GSK3B-7-E	Glycogen Synthase Kinase-3 Beta (cluster #7 Of 7), Eukaryotic	Eukaryotes	730	0.31	Binding ≤ 10μM
IKKE-1-E	Inhibitor Of Nuclear Factor Kappa B Kinase Epsilon Subunit (cluster #1 Of 1), Eukaryotic	Eukaryotes	3100	0.28	Binding ≤ 10μM
KCC2A-1-E	CaM Kinase II Alpha (cluster #1 Of 1), Eukaryotic	Eukaryotes	1700	0.29	Binding ≤ 10μM
KCC2B-1-E	CaM Kinase II Beta (cluster #1 Of 1), Eukaryotic	Eukaryotes	2600	0.28	Binding ≤ 10μM
KCC4-1-E	CaM Kinase IV (cluster #1 Of 1), Eukaryotic	Eukaryotes	3200	0.27	Binding ≤ 10μM
KIT-1-E	Stem Cell Growth Factor Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	4600	0.27	Binding ≤ 10μM
KKCC1-1-E	CaM-kinase Kinase Alpha (cluster #1 Of 1), Eukaryotic	Eukaryotes	79	0.36	Binding ≤ 10μM
KKCC2-1-E	CaM-kinase Kinase Beta (cluster #1 Of 2), Eukaryotic	Eukaryotes	430	0.32	Binding ≤ 10μM
KPCA-1-E	Protein Kinase C Alpha (cluster #1 Of 6), Eukaryotic	Eukaryotes	2800	0.28	Binding ≤ 10μM
KPCB-1-E	Protein Kinase C Beta (cluster #1 Of 4), Eukaryotic	Eukaryotes	10000	0.25	Binding ≤ 10μM
KPCD-1-E	Protein Kinase C Delta (cluster #1 Of 4), Eukaryotic	Eukaryotes	890	0.30	Binding ≤ 10μM
KPCD1-1-E	Protein Kinase C Mu (cluster #1 Of 3), Eukaryotic	Eukaryotes	520	0.31	Binding ≤ 10μM
KPCD2-1-E	Serine/threonine-protein Kinase D2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1100	0.30	Binding ≤ 10μM
KPCD3-1-E	Protein Kinase C Nu (cluster #1 Of 3), Eukaryotic	Eukaryotes	170	0.34	Binding ≤ 10μM
KPCE-1-E	Protein Kinase C Epsilon (cluster #1 Of 5), Eukaryotic	Eukaryotes	480	0.32	Binding ≤ 10μM
KPCG-1-E	Protein Kinase C Gamma (cluster #1 Of 4), Eukaryotic	Eukaryotes	10000	0.25	Binding ≤ 10μM
KPCI-1-E	Protein Kinase C Iota (cluster #1 Of 3), Eukaryotic	Eukaryotes	10000	0.25	Binding ≤ 10μM
KPCL-2-E	Protein Kinase C Eta (cluster #2 Of 4), Eukaryotic	Eukaryotes	350	0.32	Binding ≤ 10μM
KPCT-1-E	Protein Kinase C Theta (cluster #1 Of 3), Eukaryotic	Eukaryotes	350	0.32	Binding ≤ 10μM
KPCZ-1-E	Protein Kinase C Zeta (cluster #1 Of 5), Eukaryotic	Eukaryotes	10000	0.25	Binding ≤ 10μM
KS6A1-1-E	Ribosomal Protein S6 Kinase Alpha 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	720	0.31	Binding ≤ 10μM
KS6A2-1-E	Ribosomal Protein S6 Kinase Alpha 2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	1600	0.29	Binding ≤ 10μM
KS6A4-1-E	Ribosomal Protein S6 Kinase Alpha 4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1300	0.29	Binding ≤ 10μM
KS6A5-1-E	Ribosomal Protein S6 Kinase Alpha 5 (cluster #1 Of 3), Eukaryotic	Eukaryotes	2000	0.28	Binding ≤ 10μM
KS6A6-1-E	Ribosomal Protein S6 Kinase Alpha 6 (cluster #1 Of 1), Eukaryotic	Eukaryotes	800	0.30	Binding ≤ 10μM
LTK-1-E	Leukocyte Tyrosine Kinase Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	2200	0.28	Binding ≤ 10μM
M3K10-1-E	Mitogen-activated Protein Kinase Kinase Kinase 10 (cluster #1 Of 1), Eukaryotic	Eukaryotes	5200	0.26	Binding ≤ 10μM
M3K9-1-E	Mitogen-activated Protein Kinase Kinase Kinase 9 (cluster #1 Of 1), Eukaryotic	Eukaryotes	5700	0.26	Binding ≤ 10μM
M4K1-1-E	Mitogen-activated Protein Kinase Kinase Kinase Kinase 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	3300	0.27	Binding ≤ 10μM
M4K3-1-E	Mitogen-activated Protein Kinase Kinase Kinase Kinase 3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	4500	0.27	Binding ≤ 10μM
MERTK-1-E	Proto-oncogene Tyrosine-protein Kinase MER (cluster #1 Of 1), Eukaryotic	Eukaryotes	6800	0.26	Binding ≤ 10μM
MK07-1-E	Mitogen-activated Protein Kinase 7 (cluster #1 Of 1), Eukaryotic	Eukaryotes	620	0.31	Binding ≤ 10μM
MK10-1-E	C-Jun N-terminal Kinase 3 (cluster #1 Of 2), Eukaryotic	Eukaryotes	5500	0.26	Binding ≤ 10μM
MK15-1-E	Mitogen-activated Protein Kinase 15 (cluster #1 Of 1), Eukaryotic	Eukaryotes	330	0.32	Binding ≤ 10μM
MKNK2-1-E	MAP Kinase Signal-integrating Kinase 2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	3200	0.27	Binding ≤ 10μM
MRCKA-1-E	Serine/threonine-protein Kinase MRCK-A (cluster #1 Of 1), Eukaryotic	Eukaryotes	9500	0.25	Binding ≤ 10μM
MRCKB-1-E	Serine/threonine-protein Kinase MRCK Beta (cluster #1 Of 1), Eukaryotic	Eukaryotes	3300	0.27	Binding ≤ 10μM
NUAK2-1-E	NUAK Family SNF1-like Kinase 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1400	0.29	Binding ≤ 10μM
PHKG1-1-E	Phosphorylase Kinase Gamma Subunit 1 (cluster #1 Of 2), Eukaryotic	Eukaryotes	2200	0.28	Binding ≤ 10μM
PHKG2-1-E	Phosphorylase Kinase Gamma Subunit 2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	2900	0.28	Binding ≤ 10μM
PIM1-1-E	Serine/threonine-protein Kinase PIM1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	560	0.31	Binding ≤ 10μM
PIM2-1-E	Serine/threonine-protein Kinase PIM2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	770	0.31	Binding ≤ 10μM
PIM3-1-E	Serine/threonine-protein Kinase PIM3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	600	0.31	Binding ≤ 10μM
PKN1-1-E	Protein Kinase N1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	3500	0.27	Binding ≤ 10μM
PLK4-1-E	Serine/threonine-protein Kinase PLK4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	3100	0.28	Binding ≤ 10μM
PYGM-2-E	Muscle Glycogen Phosphorylase (cluster #2 Of 4), Eukaryotic	Eukaryotes	1000	0.30	Binding ≤ 10μM
SRMS-1-E	Tyrosine-protein Kinase Srms (cluster #1 Of 1), Eukaryotic	Eukaryotes	1400	0.29	Binding ≤ 10μM
ST17B-1-E	Serine/threonine-protein Kinase 17B (cluster #1 Of 1), Eukaryotic	Eukaryotes	5100	0.26	Binding ≤ 10μM
STK3-1-E	Serine/threonine-protein Kinase MST2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	9400	0.25	Binding ≤ 10μM
STK33-1-E	Serine/threonine-protein Kinase 33 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1700	0.29	Binding ≤ 10μM
TGFR2-1-E	TGF-beta Receptor Type II (cluster #1 Of 1), Eukaryotic	Eukaryotes	5600	0.26	Binding ≤ 10μM
TNI3K-1-E	Serine/threonine-protein Kinase TNNI3K (cluster #1 Of 1), Eukaryotic	Eukaryotes	55	0.36	Binding ≤ 10μM
UFO-1-E	Tyrosine-protein Kinase Receptor UFO (cluster #1 Of 1), Eukaryotic	Eukaryotes	3500	0.27	Binding ≤ 10μM
Z104294-2-O	Cyclin-dependent Kinase 5/CDK5 Activator 1 (cluster #2 Of 2), Other	Other	170	0.34	Binding ≤ 10μM
Z104295-1-O	Cyclin-dependent Kinase 4/cyclin D1 (cluster #1 Of 2), Other	Other	90	0.35	Binding ≤ 10μM
Z104295-1-O	Cyclin-dependent Kinase 4/cyclin D1 (cluster #1 Of 2), Other	Other	100	0.35	Binding ≤ 10μM
Z104296-1-O	Cyclin-dependent Kinase 1/cyclin B1 (cluster #1 Of 2), Other	Other	30	0.38	Binding ≤ 10μM
Z100090-1-O	ABAE (Fibroblast Cells) (cluster #1 Of 1), Other	Other	45	0.37	Functional ≤ 10μM
Z100091-1-O	HS27 (Fibroblast Cells) (cluster #1 Of 1), Other	Other	51	0.36	Functional ≤ 10μM
Z100093-1-O	LX-1 (Lung Carcinoma Cells) (cluster #1 Of 1), Other	Other	75	0.36	Functional ≤ 10μM
Z100094-1-O	MLF (Lung Fibroblast Cells) (cluster #1 Of 1), Other	Other	72	0.36	Functional ≤ 10μM
Z100095-1-O	MIP (Colon Carcinoma Cells) (cluster #1 Of 1), Other	Other	120	0.35	Functional ≤ 10μM
Z80054-1-O	Caco-2 (Colon Adenocarcinoma Cells) (cluster #1 Of 4), Other	Other	86	0.35	Functional ≤ 10μM
Z80064-1-O	CCRF-CEM (T-cell Leukemia) (cluster #1 Of 9), Other	Other	52	0.36	Functional ≤ 10μM
Z80156-2-O	HL-60 (Promyeloblast Leukemia Cells) (cluster #2 Of 12), Other	Other	46	0.37	Functional ≤ 10μM
Z80186-9-O	K562 (Erythroleukemia Cells) (cluster #9 Of 11), Other	Other	130	0.34	Functional ≤ 10μM
Z80224-1-O	MCF7 (Breast Carcinoma Cells) (cluster #1 Of 14), Other	Other	66	0.36	Functional ≤ 10μM
Z80354-4-O	OVCAR-3 (Ovarian Adenocarcinoma Cells) (cluster #4 Of 4), Other	Other	54	0.36	Functional ≤ 10μM
Z80390-1-O	PC-3 (Prostate Carcinoma Cells) (cluster #1 Of 10), Other	Other	66	0.36	Functional ≤ 10μM
Z80475-1-O	SK-BR-3 (Breast Adenocarcinoma) (cluster #1 Of 3), Other	Other	77	0.36	Functional ≤ 10μM
Z80675-1-O	AG1523 (Fibroblast Cells) (cluster #1 Of 1), Other	Other	6700	0.26	Functional ≤ 10μM
Z80682-1-O	A549 (Lung Carcinoma Cells) (cluster #1 Of 11), Other	Other	96	0.35	Functional ≤ 10μM
Z80852-2-O	A-431 (Epidermoid Carcinoma Cells) (cluster #2 Of 3), Other	Other	75	0.36	Functional ≤ 10μM
Z80928-1-O	HCT-116 (Colon Carcinoma Cells) (cluster #1 Of 9), Other	Other	490	0.32	Functional ≤ 10μM
Z81034-1-O	A2780 (Ovarian Carcinoma Cells) (cluster #1 Of 10), Other	Other	78	0.36	Functional ≤ 10μM
Z81170-1-O	LNCaP (Prostate Carcinoma) (cluster #1 Of 5), Other	Other	16	0.39	Functional ≤ 10μM
Z81186-1-O	LS174T (Colon Adencocarcinoma Cells) (cluster #1 Of 2), Other	Other	65	0.36	Functional ≤ 10μM
Z81225-1-O	M109 (Lung Carcinoma Cells) (cluster #1 Of 2), Other	Other	80	0.35	Functional ≤ 10μM

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	3.46	7.04	-50.59	4	6	1	95	402.854	2	↓ MOL2 SDF SMILES Flexibase
Hi High (pH 8-9.5)	3.46	7.74	-91.2	3	6	0	98	401.846	2	↓ MOL2 SDF SMILES Flexibase

14761282

Analogs

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Vendors

Activity (Go SEA)

Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
ALK-1-E	ALK Tyrosine Kinase Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	1100	0.42	Binding ≤ 10μM
AURKB-2-E	Serine/threonine-protein Kinase Aurora-B (cluster #2 Of 2), Eukaryotic	Eukaryotes	500	0.44	Binding ≤ 10μM
IGF1R-1-E	Insulin-like Growth Factor 1 Receptor (cluster #1 Of 2), Eukaryotic	Eukaryotes	8600	0.35	Binding ≤ 10μM
MET-1-E	Hepatocyte Growth Factor Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	4400	0.37	Binding ≤ 10μM
PIM1-1-E	Serine/threonine-protein Kinase PIM1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	300	0.46	Binding ≤ 10μM
PLK1-1-E	Serine/threonine-protein Kinase PLK1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	8800	0.35	Binding ≤ 10μM
UFO-1-E	Tyrosine-protein Kinase Receptor UFO (cluster #1 Of 1), Eukaryotic	Eukaryotes	6600	0.36	Binding ≤ 10μM
VGFR2-1-E	Vascular Endothelial Growth Factor Receptor 2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	800	0.43	Binding ≤ 10μM
Z80208-1-O	L5178Y (Lymphoma Cells) (cluster #1 Of 2), Other	Other	400	0.45	Functional ≤ 10μM
Z81034-6-O	A2780 (Ovarian Carcinoma Cells) (cluster #6 Of 10), Other	Other	4340	0.38	Functional ≤ 10μM
Z81057-1-O	HUVEC (Umbilical Vein Endothelial Cells) (cluster #1 Of 4), Other	Other	1800	0.40	Functional ≤ 10μM

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	2.39	-1.65	-12.14	4	6	0	111	274.228	0	↓ MOL2 SDF SMILES Flexibase

20148986

Analogs

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And 2 More

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Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
ALK-1-E	ALK Tyrosine Kinase Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	50	0.31	Binding ≤ 10μM
INSR-1-E	Insulin Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	25	0.32	Binding ≤ 10μM

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	4.34	8.53	-13.43	3	9	0	101	468.945	7	↓ MOL2 SDF SMILES Flexibase

11617039

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: Pazopanib Pazopanib

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Vendors

And 24 More

Activity (Go SEA)

Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
AAK1-1-E	Adaptor-associated Kinase (cluster #1 Of 2), Eukaryotic	Eukaryotes	2900	0.25	Binding ≤ 10μM
ABL1-1-E	Tyrosine-protein Kinase ABL (cluster #1 Of 1), Eukaryotic	Eukaryotes	3400	0.25	Binding ≤ 10μM
ABL2-1-E	Tyrosine-protein Kinase ABL2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	3000	0.25	Binding ≤ 10μM
ALK-1-E	ALK Tyrosine Kinase Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	2200	0.26	Binding ≤ 10μM
AURKA-3-E	Serine/threonine-protein Kinase Aurora-A (cluster #3 Of 3), Eukaryotic	Eukaryotes	7100	0.23	Binding ≤ 10μM
AURKC-1-E	Serine/threonine-protein Kinase Aurora-C (cluster #1 Of 2), Eukaryotic	Eukaryotes	750	0.28	Binding ≤ 10μM
AVR2B-1-E	Activin Receptor Type-2B (cluster #1 Of 1), Eukaryotic	Eukaryotes	2400	0.25	Binding ≤ 10μM
BLK-1-E	Tyrosine-protein Kinase BLK (cluster #1 Of 1), Eukaryotic	Eukaryotes	2600	0.25	Binding ≤ 10μM
BMP2K-1-E	BMP-2-inducible Protein Kinase (cluster #1 Of 2), Eukaryotic	Eukaryotes	8800	0.23	Binding ≤ 10μM
BRAF-1-E	Serine/threonine-protein Kinase B-raf (cluster #1 Of 1), Eukaryotic	Eukaryotes	730	0.28	Binding ≤ 10μM
CD11A-1-E	PITSLRE Serine/threonine-protein Kinase CDC2L2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1300	0.27	Binding ≤ 10μM
CD11B-1-E	PITSLRE Serine/threonine-protein Kinase CDC2L1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	2100	0.26	Binding ≤ 10μM
CDK16-1-E	Serine/threonine-protein Kinase PCTAIRE-1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1200	0.27	Binding ≤ 10μM
CSF1R-1-E	Macrophage Colony-stimulating Factor 1 Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	8	0.37	Binding ≤ 10μM
DDR1-1-E	Epithelial Discoidin Domain-containing Receptor 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	57	0.33	Binding ≤ 10μM
DDR2-1-E	Discoidin Domain-containing Receptor 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	98	0.32	Binding ≤ 10μM
E2AK2-1-E	Interferon-induced, Double-stranded RNA-activated Protein Kinase (cluster #1 Of 1), Eukaryotic	Eukaryotes	1900	0.26	Binding ≤ 10μM
FER-1-E	Tyrosine-protein Kinase FER (cluster #1 Of 1), Eukaryotic	Eukaryotes	2700	0.25	Binding ≤ 10μM
FGFR1-1-E	Fibroblast Growth Factor Receptor 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	990	0.27	Binding ≤ 10μM
FGFR2-1-E	Fibroblast Growth Factor Receptor 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	210	0.30	Binding ≤ 10μM
FGFR3-1-E	Fibroblast Growth Factor Receptor 3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	740	0.28	Binding ≤ 10μM
FGFR4-1-E	Fibroblast Growth Factor Receptor 4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	2800	0.25	Binding ≤ 10μM
FGR-1-E	Tyrosine-protein Kinase FGR (cluster #1 Of 2), Eukaryotic	Eukaryotes	1600	0.26	Binding ≤ 10μM
FLT3-1-E	Tyrosine-protein Kinase Receptor FLT3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	810	0.28	Binding ≤ 10μM
FRK-1-E	Tyrosine-protein Kinase FRK (cluster #1 Of 1), Eukaryotic	Eukaryotes	750	0.28	Binding ≤ 10μM
FYN-1-E	Tyrosine-protein Kinase FYN (cluster #1 Of 5), Eukaryotic	Eukaryotes	2700	0.25	Binding ≤ 10μM
GAK-1-E	Serine/threonine-protein Kinase GAK (cluster #1 Of 2), Eukaryotic	Eukaryotes	200	0.30	Binding ≤ 10μM
IRAK3-1-E	Interleukin-1 Receptor-associated Kinase 3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	800	0.28	Binding ≤ 10μM
JAK3-1-E	Tyrosine-protein Kinase JAK3 (cluster #1 Of 2), Eukaryotic	Eukaryotes	6900	0.23	Binding ≤ 10μM
KCC1A-1-E	CaM Kinase I Alpha (cluster #1 Of 2), Eukaryotic	Eukaryotes	2100	0.26	Binding ≤ 10μM
KCC1G-1-E	CaM Kinase I Gamma (cluster #1 Of 2), Eukaryotic	Eukaryotes	3700	0.25	Binding ≤ 10μM
KIT-1-E	Stem Cell Growth Factor Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	74	0.32	Binding ≤ 10μM
LCK-1-E	Tyrosine-protein Kinase LCK (cluster #1 Of 4), Eukaryotic	Eukaryotes	1200	0.27	Binding ≤ 10μM
LIMK1-1-E	LIM Domain Kinase 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	720	0.28	Binding ≤ 10μM
LIMK2-1-E	LIM Domain Kinase 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	390	0.29	Binding ≤ 10μM
LYN-1-E	Tyrosine-protein Kinase Lyn (cluster #1 Of 1), Eukaryotic	Eukaryotes	890	0.27	Binding ≤ 10μM
M3K10-1-E	Mitogen-activated Protein Kinase Kinase Kinase 10 (cluster #1 Of 1), Eukaryotic	Eukaryotes	2100	0.26	Binding ≤ 10μM
M3K11-1-E	Mitogen-activated Protein Kinase Kinase Kinase 11 (cluster #1 Of 1), Eukaryotic	Eukaryotes	740	0.28	Binding ≤ 10μM
M3K9-1-E	Mitogen-activated Protein Kinase Kinase Kinase 9 (cluster #1 Of 1), Eukaryotic	Eukaryotes	290	0.30	Binding ≤ 10μM
M4K1-1-E	Mitogen-activated Protein Kinase Kinase Kinase Kinase 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	750	0.28	Binding ≤ 10μM
M4K3-1-E	Mitogen-activated Protein Kinase Kinase Kinase Kinase 3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1600	0.26	Binding ≤ 10μM
M4K5-1-E	Mitogen-activated Protein Kinase Kinase Kinase Kinase 5 (cluster #1 Of 1), Eukaryotic	Eukaryotes	3000	0.25	Binding ≤ 10μM
MARK3-1-E	Serine/threonine-protein Kinase C-TAK1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	4000	0.24	Binding ≤ 10μM
MERTK-1-E	Proto-oncogene Tyrosine-protein Kinase MER (cluster #1 Of 1), Eukaryotic	Eukaryotes	3300	0.25	Binding ≤ 10μM
MK10-1-E	C-Jun N-terminal Kinase 3 (cluster #1 Of 2), Eukaryotic	Eukaryotes	1900	0.26	Binding ≤ 10μM
MP2K4-1-E	Dual Specificity Mitogen-activated Protein Kinase Kinase 4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	590	0.28	Binding ≤ 10μM
MP2K6-1-E	Dual Specificity Mitogen-activated Protein Kinase Kinase 6 (cluster #1 Of 1), Eukaryotic	Eukaryotes	4100	0.24	Binding ≤ 10μM
MYLK2-1-E	Myosin Light Chain Kinase 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	2000	0.26	Binding ≤ 10μM
NEK2-1-E	Serine/threonine-protein Kinase NEK2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	980	0.27	Binding ≤ 10μM
NLK-1-E	Serine/threonine Protein Kinase NLK (cluster #1 Of 1), Eukaryotic	Eukaryotes	4400	0.24	Binding ≤ 10μM
PGFRA-1-E	Platelet-derived Growth Factor Receptor Alpha (cluster #1 Of 2), Eukaryotic	Eukaryotes	5	0.37	Binding ≤ 10μM
PGFRB-1-E	Platelet-derived Growth Factor Receptor Beta (cluster #1 Of 1), Eukaryotic	Eukaryotes	84	0.32	Binding ≤ 10μM
PLK4-1-E	Serine/threonine-protein Kinase PLK4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	290	0.30	Binding ≤ 10μM
PTK6-1-E	Tyrosine-protein Kinase BRK (cluster #1 Of 1), Eukaryotic	Eukaryotes	2300	0.25	Binding ≤ 10μM
RAF1-1-E	Serine/threonine-protein Kinase RAF (cluster #1 Of 1), Eukaryotic	Eukaryotes	900	0.27	Binding ≤ 10μM
RET-1-E	Tyrosine-protein Kinase Receptor RET (cluster #1 Of 1), Eukaryotic	Eukaryotes	310	0.29	Binding ≤ 10μM
RIPK1-1-E	Receptor-interacting Serine/threonine-protein Kinase 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	260	0.30	Binding ≤ 10μM
RIPK2-1-E	Serine/threonine-protein Kinase RIPK2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	580	0.28	Binding ≤ 10μM
ROS1-1-E	Proto-oncogene Tyrosine-protein Kinase ROS (cluster #1 Of 1), Eukaryotic	Eukaryotes	920	0.27	Binding ≤ 10μM
SIK1-1-E	Serine/threonine-protein Kinase SIK1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	2200	0.26	Binding ≤ 10μM
SIK2-1-E	Serine/threonine-protein Kinase SIK2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	7300	0.23	Binding ≤ 10μM
SRC-1-E	Tyrosine-protein Kinase SRC (cluster #1 Of 3), Eukaryotic	Eukaryotes	2800	0.25	Binding ≤ 10μM
SRMS-1-E	Tyrosine-protein Kinase Srms (cluster #1 Of 1), Eukaryotic	Eukaryotes	2500	0.25	Binding ≤ 10μM
STK10-1-E	Serine/threonine-protein Kinase 10 (cluster #1 Of 1), Eukaryotic	Eukaryotes	84	0.32	Binding ≤ 10μM
STK16-1-E	Serine/threonine-protein Kinase 16 (cluster #1 Of 1), Eukaryotic	Eukaryotes	360	0.29	Binding ≤ 10μM
STK36-1-E	Serine/threonine-protein Kinase 36 (cluster #1 Of 1), Eukaryotic	Eukaryotes	470	0.29	Binding ≤ 10μM
TIE1-1-E	Tyrosine-protein Kinase Receptor Tie-1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	700	0.28	Binding ≤ 10μM
TNIK-1-E	TRAF2- And NCK-interacting Kinase (cluster #1 Of 2), Eukaryotic	Eukaryotes	310	0.29	Binding ≤ 10μM
TNK1-1-E	Non-receptor Tyrosine-protein Kinase TNK1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	980	0.27	Binding ≤ 10μM
TTK-1-E	Dual Specificity Protein Kinase TTK (cluster #1 Of 2), Eukaryotic	Eukaryotes	150	0.31	Binding ≤ 10μM
TXK-1-E	Tyrosine-protein Kinase TXK (cluster #1 Of 1), Eukaryotic	Eukaryotes	2600	0.25	Binding ≤ 10μM
VGFR1-1-E	Vascular Endothelial Growth Factor Receptor 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	14	0.35	Binding ≤ 10μM
VGFR2-1-E	Vascular Endothelial Growth Factor Receptor 2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	8	0.37	Binding ≤ 10μM
VGFR3-1-E	Vascular Endothelial Growth Factor Receptor 3 (cluster #1 Of 2), Eukaryotic	Eukaryotes	47	0.33	Binding ≤ 10μM
YES-1-E	Tyrosine-protein Kinase YES (cluster #1 Of 1), Eukaryotic	Eukaryotes	5000	0.24	Binding ≤ 10μM

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	3.27	7.86	-49.62	4	9	1	120	438.537	5	↓ MOL2 SDF SMILES Flexibase
Hi High (pH 8-9.5)	4.44	10.13	-54	3	6	1	75	422.549	6	↓ MOL2 SDF SMILES Flexibase
Hi High (pH 8-9.5)	3.01	7.81	-31.7	3	9	0	122	437.529	4	↓ MOL2 SDF SMILES Flexibase

3982130

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: L-783277 L-783277

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Vendors

eMolecules
- 36000693
AnalytiCon Discovery NP
- NP-009245

Activity (Go SEA)

Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
ALK-1-E	ALK Tyrosine Kinase Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	763	0.33	Binding ≤ 10μM
KIT-1-E	Stem Cell Growth Factor Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	303	0.35	Binding ≤ 10μM
LCK-3-E	Tyrosine-protein Kinase LCK (cluster #3 Of 4), Eukaryotic	Eukaryotes	750	0.33	Binding ≤ 10μM
MAPK5-1-E	MAP Kinase-activated Protein Kinase 5 (cluster #1 Of 1), Eukaryotic	Eukaryotes	640	0.33	Binding ≤ 10μM
MK01-1-E	Mitogen-activated Protein Kinase 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	950	0.32	Binding ≤ 10μM
MP2K2-1-E	Dual Specificity Mitogen-activated Protein Kinase Kinase 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	15	0.42	Binding ≤ 10μM
TYK2-1-E	Tyrosine-protein Kinase TYK2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	4100	0.29	Binding ≤ 10μM
VGFR2-1-E	Vascular Endothelial Growth Factor Receptor 2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	57	0.39	Binding ≤ 10μM

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	1.53	2.55	-11.63	3	7	0	113	364.394	1	↓ MOL2 SDF SMILES Flexibase
Hi High (pH 8-9.5)	1.53	3.55	-52.89	2	7	-1	116	363.386	1	↓ MOL2 SDF SMILES Flexibase
Hi High (pH 8-9.5)	1.53	3.38	-51.25	2	7	-1	116	363.386	1	↓ MOL2 SDF SMILES Flexibase

55760827

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: NVP-TAE684 NVP-TAE684

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Vendors

Activity (Go SEA)

Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
ABL1-1-E	Tyrosine-protein Kinase ABL (cluster #1 Of 1), Eukaryotic	Eukaryotes	1048	0.20	Binding ≤ 10μM
ALK-1-E	ALK Tyrosine Kinase Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	4	0.28	Binding ≤ 10μM
BMX-1-E	Tyrosine-protein Kinase BMX (cluster #1 Of 1), Eukaryotic	Eukaryotes	1578	0.19	Binding ≤ 10μM
EPHB4-1-E	Ephrin Type-B Receptor 4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1300	0.20	Binding ≤ 10μM
FGFR1-1-E	Fibroblast Growth Factor Receptor 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1216	0.20	Binding ≤ 10μM
FLT3-1-E	Tyrosine-protein Kinase Receptor FLT3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	554	0.21	Binding ≤ 10μM
INSR-1-E	Insulin Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	1200	0.20	Binding ≤ 10μM
JAK2-1-E	Tyrosine-protein Kinase JAK2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1505	0.19	Binding ≤ 10μM
LYN-1-E	Tyrosine-protein Kinase Lyn (cluster #1 Of 1), Eukaryotic	Eukaryotes	1308	0.20	Binding ≤ 10μM
MET-1-E	Hepatocyte Growth Factor Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	1667	0.19	Binding ≤ 10μM
NTRK2-1-E	Neurotrophic Tyrosine Kinase Receptor Type 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	2018	0.19	Binding ≤ 10μM
PGFRB-1-E	Platelet-derived Growth Factor Receptor Beta (cluster #1 Of 1), Eukaryotic	Eukaryotes	3220	0.18	Binding ≤ 10μM
RET-1-E	Tyrosine-protein Kinase Receptor RET (cluster #1 Of 1), Eukaryotic	Eukaryotes	1385	0.20	Binding ≤ 10μM
RON-1-E	Macrophage-stimulating Protein Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	1634	0.19	Binding ≤ 10μM
SYK-1-E	Lysyl-tRNA Synthetase (cluster #1 Of 1), Eukaryotic	Eukaryotes	286	0.22	Binding ≤ 10μM
TIE2-1-E	Tyrosine-protein Kinase TIE-2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	12	0.26	Binding ≤ 10μM
TYK2-1-E	Tyrosine-protein Kinase TYK2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	2309	0.19	Binding ≤ 10μM
VGFR1-1-E	Vascular Endothelial Growth Factor Receptor 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	872	0.20	Binding ≤ 10μM
VGFR2-1-E	Vascular Endothelial Growth Factor Receptor 2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	2123	0.19	Binding ≤ 10μM
ZAP70-1-E	Tyrosine-protein Kinase ZAP-70 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1598	0.19	Binding ≤ 10μM
SRC-1-E	Tyrosine-protein Kinase SRC (cluster #1 Of 1), Eukaryotic	Eukaryotes	1146	0.20	Functional ≤ 10μM
Z80036-1-O	BaF3 (IL-3-dependent Pro-B-cells) (cluster #1 Of 3), Other	Other	2751	0.19	Functional ≤ 10μM

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	5.66	13.62	-45.99	3	10	1	104	615.224	9	↓ MOL2 SDF SMILES Flexibase
Hi High (pH 8-9.5)	5.66	13.45	-47.5	3	10	1	104	615.224	9	↓ MOL2 SDF SMILES Flexibase
Hi High (pH 8-9.5)	5.66	11.26	-12.29	2	10	0	103	614.216	9	↓ MOL2 SDF SMILES Flexibase

3816310

Analogs

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And 20 More

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Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
AAK1-1-E	Adaptor-associated Kinase (cluster #1 Of 2), Eukaryotic	Eukaryotes	170	0.33	Binding ≤ 10μM
AAPK1-1-E	AMP-activated Protein Kinase, Alpha-1 Subunit (cluster #1 Of 1), Eukaryotic	Eukaryotes	520	0.30	Binding ≤ 10μM
AAPK2-1-E	AMP-activated Protein Kinase, Alpha-2 Subunit (cluster #1 Of 1), Eukaryotic	Eukaryotes	820	0.29	Binding ≤ 10μM
ABL1-1-E	Tyrosine-protein Kinase ABL (cluster #1 Of 1), Eukaryotic	Eukaryotes	910	0.29	Binding ≤ 10μM
ALK-1-E	ALK Tyrosine Kinase Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	3500	0.26	Binding ≤ 10μM
ANKK1-1-E	Ankyrin Repeat And Protein Kinase Domain-containing Protein 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	79	0.34	Binding ≤ 10μM
AURKB-1-E	Serine/threonine-protein Kinase Aurora-B (cluster #1 Of 2), Eukaryotic	Eukaryotes	280	0.32	Binding ≤ 10μM
AURKC-1-E	Serine/threonine-protein Kinase Aurora-C (cluster #1 Of 2), Eukaryotic	Eukaryotes	1100	0.29	Binding ≤ 10μM
BLK-1-E	Tyrosine-protein Kinase BLK (cluster #1 Of 1), Eukaryotic	Eukaryotes	190	0.32	Binding ≤ 10μM
BMP2K-1-E	BMP-2-inducible Protein Kinase (cluster #1 Of 2), Eukaryotic	Eukaryotes	54	0.35	Binding ≤ 10μM
BMPR2-1-E	Bone Morphogenetic Protein Receptor Type-2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	3100	0.27	Binding ≤ 10μM
CDK16-1-E	Serine/threonine-protein Kinase PCTAIRE-1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	430	0.31	Binding ≤ 10μM
CDK17-1-E	Serine/threonine-protein Kinase PCTAIRE-2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	3000	0.27	Binding ≤ 10μM
CDK7-1-E	Cyclin-dependent Kinase 7 (cluster #1 Of 1), Eukaryotic	Eukaryotes	2600	0.27	Binding ≤ 10μM
CHK1-1-E	Serine/threonine-protein Kinase Chk1 (cluster #1 Of 2), Eukaryotic	Eukaryotes	1200	0.29	Binding ≤ 10μM
CLK1-2-E	Dual Specificty Protein Kinase CLK1 (cluster #2 Of 2), Eukaryotic	Eukaryotes	6800	0.25	Binding ≤ 10μM
CLK2-1-E	Dual Specificity Protein Kinase CLK2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	1700	0.28	Binding ≤ 10μM
CLK4-1-E	Dual Specificity Protein Kinase CLK4 (cluster #1 Of 2), Eukaryotic	Eukaryotes	6500	0.25	Binding ≤ 10μM
CSF1R-1-E	Macrophage Colony-stimulating Factor 1 Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	60	0.35	Binding ≤ 10μM
CSK21-1-E	Casein Kinase II Alpha (cluster #1 Of 3), Eukaryotic	Eukaryotes	1400	0.28	Binding ≤ 10μM
CSK22-1-E	Casein Kinase II Alpha (prime) (cluster #1 Of 2), Eukaryotic	Eukaryotes	1600	0.28	Binding ≤ 10μM
CTRO-1-E	Citron Rho-interacting Kinase (cluster #1 Of 1), Eukaryotic	Eukaryotes	8200	0.25	Binding ≤ 10μM
DAPK3-1-E	Death-associated Protein Kinase 3 (cluster #1 Of 2), Eukaryotic	Eukaryotes	2100	0.27	Binding ≤ 10μM
DCLK3-1-E	Serine/threonine-protein Kinase DCLK3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1300	0.28	Binding ≤ 10μM
DDR1-1-E	Epithelial Discoidin Domain-containing Receptor 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	2500	0.27	Binding ≤ 10μM
E2AK2-1-E	Interferon-induced, Double-stranded RNA-activated Protein Kinase (cluster #1 Of 1), Eukaryotic	Eukaryotes	2800	0.27	Binding ≤ 10μM
E2AK4-1-E	Eukaryotic Translation Initiation Factor 2-alpha Kinase 4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	250	0.32	Binding ≤ 10μM
FGFR1-1-E	Fibroblast Growth Factor Receptor 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	166	0.33	Binding ≤ 10μM
FGFR2-1-E	Fibroblast Growth Factor Receptor 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	410	0.31	Binding ≤ 10μM
FGFR3-1-E	Fibroblast Growth Factor Receptor 3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	370	0.31	Binding ≤ 10μM
FGFR4-1-E	Fibroblast Growth Factor Receptor 4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	4300	0.26	Binding ≤ 10μM
FGR-1-E	Tyrosine-protein Kinase FGR (cluster #1 Of 2), Eukaryotic	Eukaryotes	190	0.32	Binding ≤ 10μM
FLT3-1-E	Tyrosine-protein Kinase Receptor FLT3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	6	0.40	Binding ≤ 10μM
FRK-1-E	Tyrosine-protein Kinase FRK (cluster #1 Of 1), Eukaryotic	Eukaryotes	2300	0.27	Binding ≤ 10μM
FYN-1-E	Tyrosine-protein Kinase FYN (cluster #1 Of 5), Eukaryotic	Eukaryotes	440	0.31	Binding ≤ 10μM
GAK-1-E	Serine/threonine-protein Kinase GAK (cluster #1 Of 2), Eukaryotic	Eukaryotes	490	0.30	Binding ≤ 10μM
GSK3B-1-E	Glycogen Synthase Kinase-3 Beta (cluster #1 Of 7), Eukaryotic	Eukaryotes	350	0.31	Binding ≤ 10μM
HCK-1-E	Tyrosine-protein Kinase HCK (cluster #1 Of 1), Eukaryotic	Eukaryotes	3300	0.26	Binding ≤ 10μM
IKKE-1-E	Inhibitor Of Nuclear Factor Kappa B Kinase Epsilon Subunit (cluster #1 Of 1), Eukaryotic	Eukaryotes	480	0.31	Binding ≤ 10μM
ITK-1-E	Tyrosine-protein Kinase ITK/TSK (cluster #1 Of 1), Eukaryotic	Eukaryotes	530	0.30	Binding ≤ 10μM
JAK1-1-E	Tyrosine-protein Kinase JAK1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	380	0.31	Binding ≤ 10μM
JAK2-1-E	Tyrosine-protein Kinase JAK2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	7000	0.25	Binding ≤ 10μM
JAK3-2-E	Tyrosine-protein Kinase JAK3 (cluster #2 Of 2), Eukaryotic	Eukaryotes	8700	0.24	Binding ≤ 10μM
KIT-1-E	Stem Cell Growth Factor Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	8	0.39	Binding ≤ 10μM
KKCC1-1-E	CaM-kinase Kinase Alpha (cluster #1 Of 1), Eukaryotic	Eukaryotes	3100	0.27	Binding ≤ 10μM
KPCT-1-E	Protein Kinase C Theta (cluster #1 Of 3), Eukaryotic	Eukaryotes	3200	0.27	Binding ≤ 10μM
KS6A1-1-E	Ribosomal Protein S6 Kinase Alpha 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	450	0.31	Binding ≤ 10μM
KS6A2-1-E	Ribosomal Protein S6 Kinase Alpha 2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	310	0.31	Binding ≤ 10μM
KS6A3-1-E	Ribosomal Protein S6 Kinase Alpha 3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	5600	0.25	Binding ≤ 10μM
KS6A4-1-E	Ribosomal Protein S6 Kinase Alpha 4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	590	0.30	Binding ≤ 10μM
KS6A5-1-E	Ribosomal Protein S6 Kinase Alpha 5 (cluster #1 Of 3), Eukaryotic	Eukaryotes	680	0.30	Binding ≤ 10μM
KS6A6-1-E	Ribosomal Protein S6 Kinase Alpha 6 (cluster #1 Of 1), Eukaryotic	Eukaryotes	4600	0.26	Binding ≤ 10μM
LATS1-1-E	Serine/threonine-protein Kinase LATS1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1700	0.28	Binding ≤ 10μM
LATS2-1-E	Serine/threonine-protein Kinase LATS2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	530	0.30	Binding ≤ 10μM
LCK-1-E	Tyrosine-protein Kinase LCK (cluster #1 Of 4), Eukaryotic	Eukaryotes	250	0.32	Binding ≤ 10μM
LYN-1-E	Tyrosine-protein Kinase Lyn (cluster #1 Of 1), Eukaryotic	Eukaryotes	750	0.30	Binding ≤ 10μM
M3K11-1-E	Mitogen-activated Protein Kinase Kinase Kinase 11 (cluster #1 Of 1), Eukaryotic	Eukaryotes	2200	0.27	Binding ≤ 10μM
M3K4-1-E	Mitogen-activated Protein Kinase Kinase Kinase 4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	5500	0.25	Binding ≤ 10μM
M3K9-1-E	Mitogen-activated Protein Kinase Kinase Kinase 9 (cluster #1 Of 1), Eukaryotic	Eukaryotes	9900	0.24	Binding ≤ 10μM
M4K1-1-E	Mitogen-activated Protein Kinase Kinase Kinase Kinase 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	44	0.36	Binding ≤ 10μM
M4K3-1-E	Mitogen-activated Protein Kinase Kinase Kinase Kinase 3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	560	0.30	Binding ≤ 10μM
M4K4-1-E	Mitogen-activated Protein Kinase Kinase Kinase Kinase 4 (cluster #1 Of 2), Eukaryotic	Eukaryotes	160	0.33	Binding ≤ 10μM
M4K5-1-E	Mitogen-activated Protein Kinase Kinase Kinase Kinase 5 (cluster #1 Of 1), Eukaryotic	Eukaryotes	620	0.30	Binding ≤ 10μM
MARK1-1-E	Serine/threonine-protein Kinase MARK1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	2300	0.27	Binding ≤ 10μM
MARK2-1-E	MAP/microtubule Affinity-regulating Kinase 2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	1500	0.28	Binding ≤ 10μM
MARK3-1-E	Serine/threonine-protein Kinase C-TAK1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	3400	0.26	Binding ≤ 10μM
MARK4-1-E	MAP/microtubule Affinity-regulating Kinase 4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1700	0.28	Binding ≤ 10μM
MELK-1-E	Maternal Embryonic Leucine Zipper Kinase (cluster #1 Of 1), Eukaryotic	Eukaryotes	1600	0.28	Binding ≤ 10μM
MERTK-1-E	Proto-oncogene Tyrosine-protein Kinase MER (cluster #1 Of 1), Eukaryotic	Eukaryotes	1800	0.28	Binding ≤ 10μM
MP2K1-1-E	Dual Specificity Mitogen-activated Protein Kinase Kinase 1 (cluster #1 Of 4), Eukaryotic	Eukaryotes	520	0.30	Binding ≤ 10μM
MP2K2-1-E	Dual Specificity Mitogen-activated Protein Kinase Kinase 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	350	0.31	Binding ≤ 10μM
MST4-1-E	Serine/threonine-protein Kinase MST4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	540	0.30	Binding ≤ 10μM
MUSK-1-E	Muscle, Skeletal Receptor Tyrosine Protein Kinase (cluster #1 Of 1), Eukaryotic	Eukaryotes	830	0.29	Binding ≤ 10μM
MYLK-1-E	Myosin Light Chain Kinase, Smooth Muscle (cluster #1 Of 1), Eukaryotic	Eukaryotes	3500	0.26	Binding ≤ 10μM
MYLK2-1-E	Myosin Light Chain Kinase 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	92	0.34	Binding ≤ 10μM
MYLK4-1-E	Myosin Light Chain Kinase Family Member 4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	80	0.34	Binding ≤ 10μM
NEK2-1-E	Serine/threonine-protein Kinase NEK2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	2000	0.28	Binding ≤ 10μM
NEK5-1-E	Serine/threonine-protein Kinase Nek5 (cluster #1 Of 1), Eukaryotic	Eukaryotes	2300	0.27	Binding ≤ 10μM
NEK6-1-E	Serine/threonine-protein Kinase NEK6 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1500	0.28	Binding ≤ 10μM
NEK7-1-E	Serine/threonine-protein Kinase NEK7 (cluster #1 Of 1), Eukaryotic	Eukaryotes	5600	0.25	Binding ≤ 10μM
NEK9-1-E	Serine/threonine-protein Kinase NEK9 (cluster #1 Of 1), Eukaryotic	Eukaryotes	9100	0.24	Binding ≤ 10μM
NTRK1-1-E	Nerve Growth Factor Receptor Trk-A (cluster #1 Of 1), Eukaryotic	Eukaryotes	100	0.34	Binding ≤ 10μM
NTRK2-1-E	Neurotrophic Tyrosine Kinase Receptor Type 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	720	0.30	Binding ≤ 10μM
NTRK3-1-E	NT-3 Growth Factor Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	190	0.32	Binding ≤ 10μM
NUAK1-1-E	NUAK Family SNF1-like Kinase 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	240	0.32	Binding ≤ 10μM
NUAK2-1-E	NUAK Family SNF1-like Kinase 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	130	0.33	Binding ≤ 10μM
PGFRA-1-E	Platelet-derived Growth Factor Receptor Alpha (cluster #1 Of 2), Eukaryotic	Eukaryotes	54	0.35	Binding ≤ 10μM
PGFRB-1-E	Platelet-derived Growth Factor Receptor Beta (cluster #1 Of 1), Eukaryotic	Eukaryotes	51	0.35	Binding ≤ 10μM
PHKG1-1-E	Phosphorylase Kinase Gamma Subunit 1 (cluster #1 Of 2), Eukaryotic	Eukaryotes	640	0.30	Binding ≤ 10μM
PHKG2-1-E	Phosphorylase Kinase Gamma Subunit 2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	9000	0.24	Binding ≤ 10μM
PI42B-1-E	Phosphatidylinositol-5-phosphate 4-kinase Type-2 Beta (cluster #1 Of 1), Eukaryotic	Eukaryotes	260	0.32	Binding ≤ 10μM
PI51A-1-E	Phosphatidylinositol-4-phosphate 5-kinase Type-1 Alpha (cluster #1 Of 1), Eukaryotic	Eukaryotes	1900	0.28	Binding ≤ 10μM
PKN1-1-E	Protein Kinase N1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	180	0.33	Binding ≤ 10μM
PKN2-1-E	Protein Kinase N2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	9900	0.24	Binding ≤ 10μM
RET-1-E	Tyrosine-protein Kinase Receptor RET (cluster #1 Of 1), Eukaryotic	Eukaryotes	71	0.35	Binding ≤ 10μM
RIOK1-1-E	Serine/threonine-protein Kinase RIO1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	420	0.31	Binding ≤ 10μM
RIOK3-1-E	Serine/threonine-protein Kinase RIO3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	690	0.30	Binding ≤ 10μM
RIPK1-1-E	Receptor-interacting Serine/threonine-protein Kinase 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	320	0.31	Binding ≤ 10μM
SIK2-1-E	Serine/threonine-protein Kinase SIK2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	3700	0.26	Binding ≤ 10μM
SLK-1-E	Serine/threonine-protein Kinase 2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	300	0.31	Binding ≤ 10μM
SRC-1-E	Tyrosine-protein Kinase SRC (cluster #1 Of 3), Eukaryotic	Eukaryotes	1800	0.28	Binding ≤ 10μM
SRPK1-1-E	Serine/threonine-protein Kinase SRPK1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	420	0.31	Binding ≤ 10μM
SRPK2-1-E	Serine/threonine-protein Kinase SRPK2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	290	0.32	Binding ≤ 10μM
ST17A-1-E	Serine/threonine-protein Kinase 17A (cluster #1 Of 2), Eukaryotic	Eukaryotes	830	0.29	Binding ≤ 10μM
ST17B-1-E	Serine/threonine-protein Kinase 17B (cluster #1 Of 1), Eukaryotic	Eukaryotes	1800	0.28	Binding ≤ 10μM
STK10-1-E	Serine/threonine-protein Kinase 10 (cluster #1 Of 1), Eukaryotic	Eukaryotes	550	0.30	Binding ≤ 10μM
STK11-1-E	Serine/threonine-protein Kinase 11 (cluster #1 Of 1), Eukaryotic	Eukaryotes	3700	0.26	Binding ≤ 10μM
STK24-1-E	Serine/threonine-protein Kinase 24 (cluster #1 Of 1), Eukaryotic	Eukaryotes	430	0.31	Binding ≤ 10μM
STK25-1-E	Serine/threonine-protein Kinase 25 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1200	0.29	Binding ≤ 10μM
STK3-1-E	Serine/threonine-protein Kinase MST2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	480	0.31	Binding ≤ 10μM
STK4-1-E	Serine/threonine-protein Kinase MST1 (cluster #1 Of 2), Eukaryotic	Eukaryotes	200	0.32	Binding ≤ 10μM
TIE1-1-E	Tyrosine-protein Kinase Receptor Tie-1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	4000	0.26	Binding ≤ 10μM
TLK2-1-E	Serine/threonine-protein Kinase Tousled-like 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	2600	0.27	Binding ≤ 10μM
TNIK-1-E	TRAF2- And NCK-interacting Kinase (cluster #1 Of 2), Eukaryotic	Eukaryotes	24	0.37	Binding ≤ 10μM
TYRO3-1-E	Tyrosine-protein Kinase Receptor TYRO3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	9300	0.24	Binding ≤ 10μM
UFO-1-E	Tyrosine-protein Kinase Receptor UFO (cluster #1 Of 1), Eukaryotic	Eukaryotes	3800	0.26	Binding ≤ 10μM
VGFR1-1-E	Vascular Endothelial Growth Factor Receptor 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	69	0.35	Binding ≤ 10μM
VGFR2-1-E	Vascular Endothelial Growth Factor Receptor 2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	68	0.35	Binding ≤ 10μM
VGFR3-1-E	Vascular Endothelial Growth Factor Receptor 3 (cluster #1 Of 2), Eukaryotic	Eukaryotes	580	0.30	Binding ≤ 10μM
WEE1-1-E	Serine/threonine-protein Kinase WEE1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1200	0.29	Binding ≤ 10μM
YES-1-E	Tyrosine-protein Kinase YES (cluster #1 Of 1), Eukaryotic	Eukaryotes	580	0.30	Binding ≤ 10μM

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	2.50	-4.31	-46.64	5	7	1	95	393.446	2	↓ MOL2 SDF SMILES Flexibase
Hi High (pH 8-9.5)	9.94	23.53	-6.26	1	3	0	47	633.014	17	↓ MOL2 SDF SMILES Flexibase

3964325

Analogs

13493833
13673696
36758328

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Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
AAK1-1-E	Adaptor-associated Kinase (cluster #1 Of 2), Eukaryotic	Eukaryotes	130	0.33	Binding ≤ 10μM
AAPK1-1-E	AMP-activated Protein Kinase, Alpha-1 Subunit (cluster #1 Of 1), Eukaryotic	Eukaryotes	52	0.35	Binding ≤ 10μM
AAPK2-1-E	AMP-activated Protein Kinase, Alpha-2 Subunit (cluster #1 Of 1), Eukaryotic	Eukaryotes	89	0.34	Binding ≤ 10μM
ABL1-1-E	Tyrosine-protein Kinase ABL (cluster #1 Of 1), Eukaryotic	Eukaryotes	950	0.29	Binding ≤ 10μM
ABL2-1-E	Tyrosine-protein Kinase ABL2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1200	0.29	Binding ≤ 10μM
ACK1-1-E	Tyrosine Kinase Non-receptor Protein 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	8900	0.24	Binding ≤ 10μM
AKT2-2-E	Serine/threonine-protein Kinase AKT2 (cluster #2 Of 2), Eukaryotic	Eukaryotes	2700	0.27	Binding ≤ 10μM
ALK-1-E	ALK Tyrosine Kinase Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	170	0.33	Binding ≤ 10μM
ANKK1-1-E	Ankyrin Repeat And Protein Kinase Domain-containing Protein 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	310	0.31	Binding ≤ 10μM
AURKA-1-E	Serine/threonine-protein Kinase Aurora-A (cluster #1 Of 3), Eukaryotic	Eukaryotes	6600	0.25	Binding ≤ 10μM
AURKB-1-E	Serine/threonine-protein Kinase Aurora-B (cluster #1 Of 2), Eukaryotic	Eukaryotes	380	0.31	Binding ≤ 10μM
AURKC-1-E	Serine/threonine-protein Kinase Aurora-C (cluster #1 Of 2), Eukaryotic	Eukaryotes	310	0.31	Binding ≤ 10μM
BLK-1-E	Tyrosine-protein Kinase BLK (cluster #1 Of 1), Eukaryotic	Eukaryotes	65	0.35	Binding ≤ 10μM
BMP2K-1-E	BMP-2-inducible Protein Kinase (cluster #1 Of 2), Eukaryotic	Eukaryotes	6	0.40	Binding ≤ 10μM
BMPR2-1-E	Bone Morphogenetic Protein Receptor Type-2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	570	0.30	Binding ≤ 10μM
BRD4-1-E	Bromodomain-containing Protein 4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	500	0.30	Binding ≤ 10μM
BRSK1-1-E	BR Serine/threonine-protein Kinase 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	3500	0.26	Binding ≤ 10μM
BRSK2-1-E	BR Serine/threonine-protein Kinase 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1100	0.29	Binding ≤ 10μM
CDK14-1-E	Serine/threonine-protein Kinase PFTAIRE-1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	270	0.32	Binding ≤ 10μM
CDK16-1-E	Serine/threonine-protein Kinase PCTAIRE-1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	150	0.33	Binding ≤ 10μM
CDK17-1-E	Serine/threonine-protein Kinase PCTAIRE-2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1200	0.29	Binding ≤ 10μM
CDK18-1-E	Serine/threonine-protein Kinase PCTAIRE-3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1700	0.28	Binding ≤ 10μM
CDK7-1-E	Cyclin-dependent Kinase 7 (cluster #1 Of 1), Eukaryotic	Eukaryotes	330	0.31	Binding ≤ 10μM
CDKL2-1-E	Cyclin-dependent Kinase-like 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1100	0.29	Binding ≤ 10μM
CHK1-1-E	Serine/threonine-protein Kinase Chk1 (cluster #1 Of 2), Eukaryotic	Eukaryotes	300	0.31	Binding ≤ 10μM
CHK2-1-E	Serine/threonine-protein Kinase Chk2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	7	0.39	Binding ≤ 10μM
CLK1-1-E	Dual Specificty Protein Kinase CLK1 (cluster #1 Of 2), Eukaryotic	Eukaryotes	22	0.37	Binding ≤ 10μM
CLK2-1-E	Dual Specificity Protein Kinase CLK2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	20	0.37	Binding ≤ 10μM
CLK4-1-E	Dual Specificity Protein Kinase CLK4 (cluster #1 Of 2), Eukaryotic	Eukaryotes	80	0.34	Binding ≤ 10μM
CSF1R-1-E	Macrophage Colony-stimulating Factor 1 Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	35	0.36	Binding ≤ 10μM
CSK21-1-E	Casein Kinase II Alpha (cluster #1 Of 3), Eukaryotic	Eukaryotes	81	0.34	Binding ≤ 10μM
CSK22-1-E	Casein Kinase II Alpha (prime) (cluster #1 Of 2), Eukaryotic	Eukaryotes	370	0.31	Binding ≤ 10μM
CTRO-1-E	Citron Rho-interacting Kinase (cluster #1 Of 1), Eukaryotic	Eukaryotes	3900	0.26	Binding ≤ 10μM
DAPK1-1-E	Death-associated Protein Kinase 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	120	0.33	Binding ≤ 10μM
DAPK2-1-E	Death-associated Protein Kinase 2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	470	0.31	Binding ≤ 10μM
DAPK3-1-E	Death-associated Protein Kinase 3 (cluster #1 Of 2), Eukaryotic	Eukaryotes	300	0.31	Binding ≤ 10μM
DCLK1-1-E	Serine/threonine-protein Kinase DCLK1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	370	0.31	Binding ≤ 10μM
DCLK2-1-E	Serine/threonine-protein Kinase DCLK2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	2700	0.27	Binding ≤ 10μM
DCLK3-1-E	Serine/threonine-protein Kinase DCLK3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	110	0.34	Binding ≤ 10μM
DDR1-1-E	Epithelial Discoidin Domain-containing Receptor 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	2000	0.28	Binding ≤ 10μM
DLK1-1-E	Protein Delta Homolog 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	100	0.34	Binding ≤ 10μM
DYR1A-3-E	Dual Specificity Tyrosine-phosphorylation-regulated Kinase 1A (cluster #3 Of 3), Eukaryotic	Eukaryotes	200	0.32	Binding ≤ 10μM
DYR1B-1-E	Dual Specificity Tyrosine-phosphorylation-regulated Kinase 1B (cluster #1 Of 1), Eukaryotic	Eukaryotes	2300	0.27	Binding ≤ 10μM
DYRK2-1-E	Dual-specificity Tyrosine-phosphorylation Regulated Kinase 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	680	0.30	Binding ≤ 10μM
E2AK2-1-E	Interferon-induced, Double-stranded RNA-activated Protein Kinase (cluster #1 Of 1), Eukaryotic	Eukaryotes	670	0.30	Binding ≤ 10μM
E2AK4-1-E	Eukaryotic Translation Initiation Factor 2-alpha Kinase 4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	180	0.33	Binding ≤ 10μM
EGFR-1-E	Epidermal Growth Factor Receptor ErbB1 (cluster #1 Of 4), Eukaryotic	Eukaryotes	6800	0.25	Binding ≤ 10μM
EPHA3-1-E	Ephrin Type-A Receptor 3 (cluster #1 Of 2), Eukaryotic	Eukaryotes	2100	0.27	Binding ≤ 10μM
EPHA5-1-E	Ephrin Type-A Receptor 5 (cluster #1 Of 1), Eukaryotic	Eukaryotes	5900	0.25	Binding ≤ 10μM
EPHA6-1-E	Ephrin Type-A Receptor 6 (cluster #1 Of 1), Eukaryotic	Eukaryotes	960	0.29	Binding ≤ 10μM
EPHA7-1-E	Ephrin Type-A Receptor 7 (cluster #1 Of 1), Eukaryotic	Eukaryotes	710	0.30	Binding ≤ 10μM
EPHB1-1-E	Ephrin Type-B Receptor 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	960	0.29	Binding ≤ 10μM
EPHB4-1-E	Ephrin Type-B Receptor 4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	2200	0.27	Binding ≤ 10μM
EPHB6-1-E	Ephrin Type-B Receptor 6 (cluster #1 Of 1), Eukaryotic	Eukaryotes	850	0.29	Binding ≤ 10μM
ERN1-1-E	Serine/threonine-protein Kinase/endoribonuclease IRE1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	600	0.30	Binding ≤ 10μM
FAK1-1-E	Focal Adhesion Kinase 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	610	0.30	Binding ≤ 10μM
FAK2-1-E	Protein-tyrosine Kinase 2-beta (cluster #1 Of 1), Eukaryotic	Eukaryotes	82	0.34	Binding ≤ 10μM
FER-1-E	Tyrosine-protein Kinase FER (cluster #1 Of 1), Eukaryotic	Eukaryotes	1400	0.28	Binding ≤ 10μM
FES-1-E	Tyrosine-protein Kinase FES (cluster #1 Of 1), Eukaryotic	Eukaryotes	960	0.29	Binding ≤ 10μM
FGFR1-1-E	Fibroblast Growth Factor Receptor 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	520	0.30	Binding ≤ 10μM
FGFR2-1-E	Fibroblast Growth Factor Receptor 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	570	0.30	Binding ≤ 10μM
FGFR3-1-E	Fibroblast Growth Factor Receptor 3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	300	0.31	Binding ≤ 10μM
FGR-1-E	Tyrosine-protein Kinase FGR (cluster #1 Of 2), Eukaryotic	Eukaryotes	290	0.32	Binding ≤ 10μM
FLT3-1-E	Tyrosine-protein Kinase Receptor FLT3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	10	0.39	Binding ≤ 10μM
FRK-1-E	Tyrosine-protein Kinase FRK (cluster #1 Of 1), Eukaryotic	Eukaryotes	530	0.30	Binding ≤ 10μM
FYN-1-E	Tyrosine-protein Kinase FYN (cluster #1 Of 5), Eukaryotic	Eukaryotes	520	0.30	Binding ≤ 10μM
GAK-1-E	Serine/threonine-protein Kinase GAK (cluster #1 Of 2), Eukaryotic	Eukaryotes	20	0.37	Binding ≤ 10μM
GRK4-1-E	G Protein-coupled Receptor Kinase 4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	140	0.33	Binding ≤ 10μM
GRK7-1-E	G Protein-coupled Receptor Kinase 7 (cluster #1 Of 1), Eukaryotic	Eukaryotes	180	0.33	Binding ≤ 10μM
HCK-1-E	Tyrosine-protein Kinase HCK (cluster #1 Of 1), Eukaryotic	Eukaryotes	880	0.29	Binding ≤ 10μM
HIPK2-1-E	Homeodomain-interacting Protein Kinase 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	31	0.36	Binding ≤ 10μM
HIPK3-1-E	Homeodomain-interacting Protein Kinase 3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	41	0.36	Binding ≤ 10μM
HIPK4-1-E	Homeodomain-interacting Protein Kinase 4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	160	0.33	Binding ≤ 10μM
ICK-1-E	Serine/threonine-protein Kinase ICK (cluster #1 Of 1), Eukaryotic	Eukaryotes	470	0.31	Binding ≤ 10μM
IGF1R-1-E	Insulin-like Growth Factor 1 Receptor (cluster #1 Of 2), Eukaryotic	Eukaryotes	2600	0.27	Binding ≤ 10μM
IKKA-1-E	Inhibitor Of Nuclear Factor Kappa B Kinase Alpha Subunit (cluster #1 Of 3), Eukaryotic	Eukaryotes	520	0.30	Binding ≤ 10μM
IKKE-1-E	Inhibitor Of Nuclear Factor Kappa B Kinase Epsilon Subunit (cluster #1 Of 1), Eukaryotic	Eukaryotes	620	0.30	Binding ≤ 10μM
INSR-1-E	Insulin Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	500	0.30	Binding ≤ 10μM
INSRR-1-E	Insulin Receptor-related Protein (cluster #1 Of 1), Eukaryotic	Eukaryotes	430	0.31	Binding ≤ 10μM
IRAK1-1-E	Interleukin-1 Receptor-associated Kinase 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	14	0.38	Binding ≤ 10μM
IRAK3-1-E	Interleukin-1 Receptor-associated Kinase 3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	940	0.29	Binding ≤ 10μM
ITK-1-E	Tyrosine-protein Kinase ITK/TSK (cluster #1 Of 1), Eukaryotic	Eukaryotes	13	0.38	Binding ≤ 10μM
JAK1-1-E	Tyrosine-protein Kinase JAK1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	9	0.39	Binding ≤ 10μM
JAK2-1-E	Tyrosine-protein Kinase JAK2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	940	0.29	Binding ≤ 10μM
JAK3-1-E	Tyrosine-protein Kinase JAK3 (cluster #1 Of 2), Eukaryotic	Eukaryotes	1200	0.29	Binding ≤ 10μM
KC1A-1-E	Casein Kinase I Alpha (cluster #1 Of 1), Eukaryotic	Eukaryotes	550	0.30	Binding ≤ 10μM
KC1AL-1-E	Casein Kinase I Isoform Alpha-like (cluster #1 Of 1), Eukaryotic	Eukaryotes	550	0.30	Binding ≤ 10μM
KC1D-1-E	Casein Kinase I Delta (cluster #1 Of 1), Eukaryotic	Eukaryotes	15	0.38	Binding ≤ 10μM
KC1E-1-E	Casein Kinase I Epsilon (cluster #1 Of 2), Eukaryotic	Eukaryotes	13	0.38	Binding ≤ 10μM
KC1G1-1-E	Casein Kinase I Gamma 1 (cluster #1 Of 2), Eukaryotic	Eukaryotes	930	0.29	Binding ≤ 10μM
KC1G2-1-E	Casein Kinase I Gamma 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	110	0.34	Binding ≤ 10μM
KC1G3-1-E	Casein Kinase I Isoform Gamma-3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	240	0.32	Binding ≤ 10μM
KCC1A-1-E	CaM Kinase I Alpha (cluster #1 Of 2), Eukaryotic	Eukaryotes	970	0.29	Binding ≤ 10μM
KCC1D-1-E	CaM Kinase I Delta (cluster #1 Of 2), Eukaryotic	Eukaryotes	510	0.30	Binding ≤ 10μM
KCC1G-1-E	CaM Kinase I Gamma (cluster #1 Of 2), Eukaryotic	Eukaryotes	990	0.29	Binding ≤ 10μM
KCC2A-1-E	CaM Kinase II Alpha (cluster #1 Of 1), Eukaryotic	Eukaryotes	80	0.34	Binding ≤ 10μM
KCC2B-1-E	CaM Kinase II Beta (cluster #1 Of 1), Eukaryotic	Eukaryotes	3200	0.27	Binding ≤ 10μM
KCC2D-1-E	CaM Kinase II Delta (cluster #1 Of 1), Eukaryotic	Eukaryotes	420	0.31	Binding ≤ 10μM
KCC2G-1-E	CaM Kinase II Gamma (cluster #1 Of 1), Eukaryotic	Eukaryotes	760	0.30	Binding ≤ 10μM
KCC4-1-E	CaM Kinase IV (cluster #1 Of 1), Eukaryotic	Eukaryotes	890	0.29	Binding ≤ 10μM
KIT-1-E	Stem Cell Growth Factor Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	380	0.31	Binding ≤ 10μM
KKCC1-1-E	CaM-kinase Kinase Alpha (cluster #1 Of 1), Eukaryotic	Eukaryotes	900	0.29	Binding ≤ 10μM
KKCC2-1-E	CaM-kinase Kinase Beta (cluster #1 Of 2), Eukaryotic	Eukaryotes	5800	0.25	Binding ≤ 10μM
KPCA-1-E	Protein Kinase C Alpha (cluster #1 Of 6), Eukaryotic	Eukaryotes	6000	0.25	Binding ≤ 10μM
KPCD1-1-E	Protein Kinase C Mu (cluster #1 Of 3), Eukaryotic	Eukaryotes	310	0.31	Binding ≤ 10μM
KPCD2-1-E	Serine/threonine-protein Kinase D2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	380	0.31	Binding ≤ 10μM
KPCD3-1-E	Protein Kinase C Nu (cluster #1 Of 3), Eukaryotic	Eukaryotes	280	0.32	Binding ≤ 10μM
KPCT-1-E	Protein Kinase C Theta (cluster #1 Of 3), Eukaryotic	Eukaryotes	4300	0.26	Binding ≤ 10μM
KS6A1-1-E	Ribosomal Protein S6 Kinase Alpha 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	96	0.34	Binding ≤ 10μM
KS6A2-1-E	Ribosomal Protein S6 Kinase Alpha 2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	8400	0.25	Binding ≤ 10μM
KS6A3-1-E	Ribosomal Protein S6 Kinase Alpha 3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	580	0.30	Binding ≤ 10μM
KS6A4-1-E	Ribosomal Protein S6 Kinase Alpha 4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	96	0.34	Binding ≤ 10μM
KS6A5-1-E	Ribosomal Protein S6 Kinase Alpha 5 (cluster #1 Of 3), Eukaryotic	Eukaryotes	8400	0.25	Binding ≤ 10μM
KS6A6-1-E	Ribosomal Protein S6 Kinase Alpha 6 (cluster #1 Of 1), Eukaryotic	Eukaryotes	2400	0.27	Binding ≤ 10μM
KS6B1-1-E	Ribosomal Protein S6 Kinase 1 (cluster #1 Of 2), Eukaryotic	Eukaryotes	200	0.32	Binding ≤ 10μM
LATS1-1-E	Serine/threonine-protein Kinase LATS1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	630	0.30	Binding ≤ 10μM
LATS2-1-E	Serine/threonine-protein Kinase LATS2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	460	0.31	Binding ≤ 10μM
LCK-1-E	Tyrosine-protein Kinase LCK (cluster #1 Of 4), Eukaryotic	Eukaryotes	230	0.32	Binding ≤ 10μM
LTK-1-E	Leukocyte Tyrosine Kinase Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	1800	0.28	Binding ≤ 10μM
LYN-1-E	Tyrosine-protein Kinase Lyn (cluster #1 Of 1), Eukaryotic	Eukaryotes	540	0.30	Binding ≤ 10μM
M3K11-1-E	Mitogen-activated Protein Kinase Kinase Kinase 11 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1300	0.28	Binding ≤ 10μM
M3K13-1-E	Mitogen-activated Protein Kinase Kinase Kinase 13 (cluster #1 Of 1), Eukaryotic	Eukaryotes	95	0.34	Binding ≤ 10μM
M3K15-1-E	Mitogen-activated Protein Kinase Kinase Kinase 15 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1300	0.28	Binding ≤ 10μM
M3K2-1-E	Mitogen-activated Protein Kinase Kinase Kinase 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	57	0.35	Binding ≤ 10μM
M3K3-1-E	Mitogen-activated Protein Kinase Kinase Kinase 3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	220	0.32	Binding ≤ 10μM
M3K4-1-E	Mitogen-activated Protein Kinase Kinase Kinase 4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	3300	0.26	Binding ≤ 10μM
M3K7-1-E	Mitogen-activated Protein Kinase Kinase Kinase 7 (cluster #1 Of 1), Eukaryotic	Eukaryotes	93	0.34	Binding ≤ 10μM
M3K9-1-E	Mitogen-activated Protein Kinase Kinase Kinase 9 (cluster #1 Of 1), Eukaryotic	Eukaryotes	3400	0.26	Binding ≤ 10μM
M4K1-1-E	Mitogen-activated Protein Kinase Kinase Kinase Kinase 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	16	0.38	Binding ≤ 10μM
M4K3-1-E	Mitogen-activated Protein Kinase Kinase Kinase Kinase 3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	180	0.33	Binding ≤ 10μM
M4K4-1-E	Mitogen-activated Protein Kinase Kinase Kinase Kinase 4 (cluster #1 Of 2), Eukaryotic	Eukaryotes	140	0.33	Binding ≤ 10μM
M4K5-1-E	Mitogen-activated Protein Kinase Kinase Kinase Kinase 5 (cluster #1 Of 1), Eukaryotic	Eukaryotes	77	0.34	Binding ≤ 10μM
MARK1-1-E	Serine/threonine-protein Kinase MARK1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1200	0.29	Binding ≤ 10μM
MARK2-1-E	MAP/microtubule Affinity-regulating Kinase 2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	320	0.31	Binding ≤ 10μM
MARK3-1-E	Serine/threonine-protein Kinase C-TAK1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	640	0.30	Binding ≤ 10μM
MARK4-1-E	MAP/microtubule Affinity-regulating Kinase 4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	3600	0.26	Binding ≤ 10μM
MAST1-1-E	Microtubule-associated Serine/threonine-protein Kinase 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	200	0.32	Binding ≤ 10μM
MELK-1-E	Maternal Embryonic Leucine Zipper Kinase (cluster #1 Of 1), Eukaryotic	Eukaryotes	350	0.31	Binding ≤ 10μM
MERTK-1-E	Proto-oncogene Tyrosine-protein Kinase MER (cluster #1 Of 1), Eukaryotic	Eukaryotes	26	0.37	Binding ≤ 10μM
MET-1-E	Hepatocyte Growth Factor Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	2000	0.28	Binding ≤ 10μM
MINK1-1-E	Misshapen-like Kinase 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	29	0.36	Binding ≤ 10μM
MP2K1-1-E	Dual Specificity Mitogen-activated Protein Kinase Kinase 1 (cluster #1 Of 4), Eukaryotic	Eukaryotes	130	0.33	Binding ≤ 10μM
MP2K2-1-E	Dual Specificity Mitogen-activated Protein Kinase Kinase 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	110	0.34	Binding ≤ 10μM
MST4-1-E	Serine/threonine-protein Kinase MST4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	340	0.31	Binding ≤ 10μM
MUSK-1-E	Muscle, Skeletal Receptor Tyrosine Protein Kinase (cluster #1 Of 1), Eukaryotic	Eukaryotes	490	0.30	Binding ≤ 10μM
MYLK-1-E	Myosin Light Chain Kinase, Smooth Muscle (cluster #1 Of 1), Eukaryotic	Eukaryotes	280	0.32	Binding ≤ 10μM
MYLK2-1-E	Myosin Light Chain Kinase 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	57	0.35	Binding ≤ 10μM
MYLK4-1-E	Myosin Light Chain Kinase Family Member 4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	15	0.38	Binding ≤ 10μM
MYO3B-1-E	Myosin-IIIB (cluster #1 Of 1), Eukaryotic	Eukaryotes	4500	0.26	Binding ≤ 10μM
NEK2-1-E	Serine/threonine-protein Kinase NEK2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	500	0.30	Binding ≤ 10μM
NEK7-1-E	Serine/threonine-protein Kinase NEK7 (cluster #1 Of 1), Eukaryotic	Eukaryotes	4100	0.26	Binding ≤ 10μM
NIM1-1-E	Serine/threonine-protein Kinase NIM1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	850	0.29	Binding ≤ 10μM
NTRK1-1-E	Nerve Growth Factor Receptor Trk-A (cluster #1 Of 1), Eukaryotic	Eukaryotes	220	0.32	Binding ≤ 10μM
NTRK2-1-E	Neurotrophic Tyrosine Kinase Receptor Type 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	590	0.30	Binding ≤ 10μM
NTRK3-1-E	NT-3 Growth Factor Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	5100	0.26	Binding ≤ 10μM
NUAK1-1-E	NUAK Family SNF1-like Kinase 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	48	0.35	Binding ≤ 10μM
NUAK2-1-E	NUAK Family SNF1-like Kinase 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	150	0.33	Binding ≤ 10μM
OXSR1-1-E	Serine/threonine-protein Kinase OSR1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	530	0.30	Binding ≤ 10μM
PAK3-1-E	Serine/threonine-protein Kinase PAK 3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	16	0.38	Binding ≤ 10μM
PAK4-1-E	Serine/threonine-protein Kinase PAK 4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	2300	0.27	Binding ≤ 10μM
PAK6-1-E	Serine/threonine-protein Kinase PAK6 (cluster #1 Of 1), Eukaryotic	Eukaryotes	2400	0.27	Binding ≤ 10μM
PAK7-1-E	Serine/threonine-protein Kinase PAK7 (cluster #1 Of 1), Eukaryotic	Eukaryotes	640	0.30	Binding ≤ 10μM
PDPK1-1-E	3-phosphoinositide Dependent Protein Kinase-1 (cluster #1 Of 2), Eukaryotic	Eukaryotes	3500	0.26	Binding ≤ 10μM
PGFRA-1-E	Platelet-derived Growth Factor Receptor Alpha (cluster #1 Of 2), Eukaryotic	Eukaryotes	1	0.43	Binding ≤ 10μM
PGFRB-1-E	Platelet-derived Growth Factor Receptor Beta (cluster #1 Of 1), Eukaryotic	Eukaryotes	9	0.39	Binding ≤ 10μM
PHKG1-1-E	Phosphorylase Kinase Gamma Subunit 1 (cluster #1 Of 2), Eukaryotic	Eukaryotes	70	0.35	Binding ≤ 10μM
PHKG2-1-E	Phosphorylase Kinase Gamma Subunit 2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	6	0.40	Binding ≤ 10μM
PI42B-1-E	Phosphatidylinositol-5-phosphate 4-kinase Type-2 Beta (cluster #1 Of 1), Eukaryotic	Eukaryotes	39	0.36	Binding ≤ 10μM
PI51A-1-E	Phosphatidylinositol-4-phosphate 5-kinase Type-1 Alpha (cluster #1 Of 1), Eukaryotic	Eukaryotes	5400	0.25	Binding ≤ 10μM
PIM2-1-E	Serine/threonine-protein Kinase PIM2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	5000	0.26	Binding ≤ 10μM
PIM3-1-E	Serine/threonine-protein Kinase PIM3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	2400	0.27	Binding ≤ 10μM
PKN1-1-E	Protein Kinase N1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	710	0.30	Binding ≤ 10μM
PKN2-1-E	Protein Kinase N2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1300	0.28	Binding ≤ 10μM
PLK2-1-E	Serine/threonine-protein Kinase PLK2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	4700	0.26	Binding ≤ 10μM
PLK4-1-E	Serine/threonine-protein Kinase PLK4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	380	0.31	Binding ≤ 10μM
PRP4-1-E	U4/U6 Small Nuclear Ribonucleoprotein Prp4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	390	0.31	Binding ≤ 10μM
RET-1-E	Tyrosine-protein Kinase Receptor RET (cluster #1 Of 1), Eukaryotic	Eukaryotes	19	0.37	Binding ≤ 10μM
RIOK1-1-E	Serine/threonine-protein Kinase RIO1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	35	0.36	Binding ≤ 10μM
RIOK2-1-E	Serine/threonine-protein Kinase RIO2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	49	0.35	Binding ≤ 10μM
RIOK3-1-E	Serine/threonine-protein Kinase RIO3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	3800	0.26	Binding ≤ 10μM
RIPK1-1-E	Receptor-interacting Serine/threonine-protein Kinase 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	370	0.31	Binding ≤ 10μM
RIPK4-1-E	Receptor-interacting Serine/threonine-protein Kinase 4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	2100	0.27	Binding ≤ 10μM
RK-1-E	Rhodopsin Kinase (cluster #1 Of 1), Eukaryotic	Eukaryotes	290	0.32	Binding ≤ 10μM
ROCK1-1-E	Rho-associated Protein Kinase 1 (cluster #1 Of 2), Eukaryotic	Eukaryotes	460	0.31	Binding ≤ 10μM
ROCK2-1-E	Rho-associated Protein Kinase 2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	140	0.33	Binding ≤ 10μM
SG110-1-E	Putative Uncharacterized Serine/threonine-protein Kinase SgK110 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1900	0.28	Binding ≤ 10μM
SIK1-1-E	Serine/threonine-protein Kinase SIK1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	3200	0.27	Binding ≤ 10μM
SIK2-1-E	Serine/threonine-protein Kinase SIK2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	580	0.30	Binding ≤ 10μM
SLK-1-E	Serine/threonine-protein Kinase 2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	81	0.34	Binding ≤ 10μM
SRC-1-E	Tyrosine-protein Kinase SRC (cluster #1 Of 3), Eukaryotic	Eukaryotes	400	0.31	Binding ≤ 10μM
SRPK1-1-E	Serine/threonine-protein Kinase SRPK1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	250	0.32	Binding ≤ 10μM
SRPK2-1-E	Serine/threonine-protein Kinase SRPK2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	190	0.32	Binding ≤ 10μM
SRPK3-1-E	Serine/threonine-protein Kinase SRPK3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	59	0.35	Binding ≤ 10μM
ST17A-1-E	Serine/threonine-protein Kinase 17A (cluster #1 Of 2), Eukaryotic	Eukaryotes	21	0.37	Binding ≤ 10μM
ST17B-1-E	Serine/threonine-protein Kinase 17B (cluster #1 Of 1), Eukaryotic	Eukaryotes	220	0.32	Binding ≤ 10μM
ST38L-1-E	Serine/threonine-protein Kinase 38-like (cluster #1 Of 2), Eukaryotic	Eukaryotes	970	0.29	Binding ≤ 10μM
STK10-1-E	Serine/threonine-protein Kinase 10 (cluster #1 Of 1), Eukaryotic	Eukaryotes	640	0.30	Binding ≤ 10μM
STK11-1-E	Serine/threonine-protein Kinase 11 (cluster #1 Of 1), Eukaryotic	Eukaryotes	38	0.36	Binding ≤ 10μM
STK16-1-E	Serine/threonine-protein Kinase 16 (cluster #1 Of 1), Eukaryotic	Eukaryotes	360	0.31	Binding ≤ 10μM
STK24-1-E	Serine/threonine-protein Kinase 24 (cluster #1 Of 1), Eukaryotic	Eukaryotes	63	0.35	Binding ≤ 10μM
STK25-1-E	Serine/threonine-protein Kinase 25 (cluster #1 Of 1), Eukaryotic	Eukaryotes	290	0.32	Binding ≤ 10μM
STK3-1-E	Serine/threonine-protein Kinase MST2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	160	0.33	Binding ≤ 10μM
STK33-1-E	Serine/threonine-protein Kinase 33 (cluster #1 Of 1), Eukaryotic	Eukaryotes	17	0.38	Binding ≤ 10μM
STK35-1-E	Serine/threonine-protein Kinase 35 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1300	0.28	Binding ≤ 10μM
STK38-1-E	Serine/threonine-protein Kinase 38 (cluster #1 Of 1), Eukaryotic	Eukaryotes	410	0.31	Binding ≤ 10μM
STK39-1-E	STE20/SPS1-related Proline-alanine-rich Protein Kinase (cluster #1 Of 1), Eukaryotic	Eukaryotes	140	0.33	Binding ≤ 10μM
STK4-1-E	Serine/threonine-protein Kinase MST1 (cluster #1 Of 2), Eukaryotic	Eukaryotes	19	0.37	Binding ≤ 10μM
TAOK1-1-E	Serine/threonine-protein Kinase TAO1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	890	0.29	Binding ≤ 10μM
TAOK3-1-E	Serine/threonine-protein Kinase TAO3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	210	0.32	Binding ≤ 10μM
TBK1-1-E	Serine/threonine-protein Kinase TBK1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	120	0.33	Binding ≤ 10μM
TLK1-1-E	Serine/threonine-protein Kinase Tousled-like 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	740	0.30	Binding ≤ 10μM
TLK2-1-E	Serine/threonine-protein Kinase Tousled-like 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	330	0.31	Binding ≤ 10μM
TNIK-1-E	TRAF2- And NCK-interacting Kinase (cluster #1 Of 2), Eukaryotic	Eukaryotes	25	0.37	Binding ≤ 10μM
TNK1-1-E	Non-receptor Tyrosine-protein Kinase TNK1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	680	0.30	Binding ≤ 10μM
TNKS2-1-E	Tankyrase-2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	8900	0.24	Binding ≤ 10μM
TSSK1-1-E	Testis-specific Serine/threonine-protein Kinase 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	6300	0.25	Binding ≤ 10μM
TTK-1-E	Dual Specificity Protein Kinase TTK (cluster #1 Of 2), Eukaryotic	Eukaryotes	63	0.35	Binding ≤ 10μM
TYK2-1-E	Tyrosine-protein Kinase TYK2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	360	0.31	Binding ≤ 10μM
TYRO3-1-E	Tyrosine-protein Kinase Receptor TYRO3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	49	0.35	Binding ≤ 10μM
UFO-1-E	Tyrosine-protein Kinase Receptor UFO (cluster #1 Of 1), Eukaryotic	Eukaryotes	9	0.39	Binding ≤ 10μM
ULK1-1-E	Serine/threonine-protein Kinase ULK1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	23	0.37	Binding ≤ 10μM
ULK2-1-E	Serine/threonine-protein Kinase ULK2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	13	0.38	Binding ≤ 10μM
ULK3-1-E	Serine/threonine-protein Kinase ULK3 (cluster #1 Of 2), Eukaryotic	Eukaryotes	42	0.36	Binding ≤ 10μM
VGFR1-1-E	Vascular Endothelial Growth Factor Receptor 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	50	0.35	Binding ≤ 10μM
VGFR2-1-E	Vascular Endothelial Growth Factor Receptor 2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	98	0.34	Binding ≤ 10μM
VGFR3-1-E	Vascular Endothelial Growth Factor Receptor 3 (cluster #1 Of 2), Eukaryotic	Eukaryotes	9	0.39	Binding ≤ 10μM
WEE1-1-E	Serine/threonine-protein Kinase WEE1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1100	0.29	Binding ≤ 10μM
YES-1-E	Tyrosine-protein Kinase YES (cluster #1 Of 1), Eukaryotic	Eukaryotes	240	0.32	Binding ≤ 10μM
YSK4-1-E	SPS1/STE20-related Protein Kinase YSK4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	17	0.38	Binding ≤ 10μM
PGFRA-1-E	Platelet-derived Growth Factor Receptor Alpha (cluster #1 Of 1), Eukaryotic	Eukaryotes	83	0.34	Functional ≤ 10μM
PGFRB-1-E	Platelet-derived Growth Factor Receptor Beta (cluster #1 Of 1), Eukaryotic	Eukaryotes	83	0.34	Functional ≤ 10μM
Z100405-1-O	MV4-11 (Myeloid Leukemia Cells) (cluster #1 Of 1), Other	Other	9	0.39	Functional ≤ 10μM
Z80101-2-O	COLO 320DM (Colon Adenocarcinoma Cells) (cluster #2 Of 2), Other	Other	1	0.43	Functional ≤ 10μM
Z80156-2-O	HL-60 (Promyeloblast Leukemia Cells) (cluster #2 Of 12), Other	Other	3530	0.26	Functional ≤ 10μM
Z80166-1-O	HT-29 (Colon Adenocarcinoma Cells) (cluster #1 Of 12), Other	Other	1300	0.28	Functional ≤ 10μM
Z80186-1-O	K562 (Erythroleukemia Cells) (cluster #1 Of 11), Other	Other	2410	0.27	Functional ≤ 10μM
Z80548-1-O	THP-1 (Acute Monocytic Leukemia Cells) (cluster #1 Of 5), Other	Other	500	0.30	Functional ≤ 10μM
Z80682-1-O	A549 (Lung Carcinoma Cells) (cluster #1 Of 11), Other	Other	6610	0.25	Functional ≤ 10μM
Z81020-4-O	HepG2 (Hepatoblastoma Cells) (cluster #4 Of 8), Other	Other	3810	0.26	Functional ≤ 10μM
Z81057-1-O	HUVEC (Umbilical Vein Endothelial Cells) (cluster #1 Of 4), Other	Other	4040	0.26	Functional ≤ 10μM
Z81252-1-O	MDA-MB-231 (Breast Adenocarcinoma Cells) (cluster #1 Of 11), Other	Other	4510	0.26	Functional ≤ 10μM
Z103203-1-O	A375 (cluster #1 Of 1), Other	Other	5400	0.25	ADME/T ≤ 10μM

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	1.95	8.37	-42.56	4	6	1	82	399.49	7	↓ MOL2 SDF SMILES Flexibase

1546066

Analogs

22065493

Draw Identity 99% 90% 80% 70%

Popular Name: Erlotinib Erlotinib

Find On: PubMed — Wikipedia — Google

Vendors

And 64 More

Activity (Go SEA)

Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
AAK1-1-E	Adaptor-associated Kinase (cluster #1 Of 2), Eukaryotic	Eukaryotes	4400	0.26	Binding ≤ 10μM
ABL1-1-E	Tyrosine-protein Kinase ABL (cluster #1 Of 1), Eukaryotic	Eukaryotes	770	0.30	Binding ≤ 10μM
ABL2-1-E	Tyrosine-protein Kinase ABL2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	300	0.31	Binding ≤ 10μM
ADCK3-1-E	Chaperone Activity Of Bc1 Complex-like, Mitochondrial (cluster #1 Of 1), Eukaryotic	Eukaryotes	1900	0.28	Binding ≤ 10μM
ADCK4-1-E	Uncharacterized AarF Domain-containing Protein Kinase 4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	2500	0.27	Binding ≤ 10μM
ALK-1-E	ALK Tyrosine Kinase Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	1200	0.29	Binding ≤ 10μM
AURKA-3-E	Serine/threonine-protein Kinase Aurora-A (cluster #3 Of 3), Eukaryotic	Eukaryotes	3800	0.26	Binding ≤ 10μM
AURKB-1-E	Serine/threonine-protein Kinase Aurora-B (cluster #1 Of 2), Eukaryotic	Eukaryotes	1400	0.28	Binding ≤ 10μM
AURKC-1-E	Serine/threonine-protein Kinase Aurora-C (cluster #1 Of 2), Eukaryotic	Eukaryotes	600	0.30	Binding ≤ 10μM
BLK-1-E	Tyrosine-protein Kinase BLK (cluster #1 Of 1), Eukaryotic	Eukaryotes	190	0.32	Binding ≤ 10μM
BMP2K-1-E	BMP-2-inducible Protein Kinase (cluster #1 Of 2), Eukaryotic	Eukaryotes	1800	0.28	Binding ≤ 10μM
CTRO-1-E	Citron Rho-interacting Kinase (cluster #1 Of 1), Eukaryotic	Eukaryotes	680	0.30	Binding ≤ 10μM
DDR1-1-E	Epithelial Discoidin Domain-containing Receptor 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	790	0.29	Binding ≤ 10μM
DMPK-1-E	Myotonin-protein Kinase (cluster #1 Of 1), Eukaryotic	Eukaryotes	2900	0.27	Binding ≤ 10μM
E2AK2-1-E	Interferon-induced, Double-stranded RNA-activated Protein Kinase (cluster #1 Of 1), Eukaryotic	Eukaryotes	1300	0.28	Binding ≤ 10μM
E2AK4-1-E	Eukaryotic Translation Initiation Factor 2-alpha Kinase 4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	4400	0.26	Binding ≤ 10μM
EGFR-3-E	Epidermal Growth Factor Receptor ErbB1 (cluster #3 Of 4), Eukaryotic	Eukaryotes	51	0.35	Binding ≤ 10μM
EPHA3-1-E	Ephrin Type-A Receptor 3 (cluster #1 Of 2), Eukaryotic	Eukaryotes	2400	0.27	Binding ≤ 10μM
EPHA6-1-E	Ephrin Type-A Receptor 6 (cluster #1 Of 1), Eukaryotic	Eukaryotes	930	0.29	Binding ≤ 10μM
EPHA7-1-E	Ephrin Type-A Receptor 7 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1400	0.28	Binding ≤ 10μM
EPHA8-1-E	Ephrin Type-A Receptor 8 (cluster #1 Of 1), Eukaryotic	Eukaryotes	940	0.29	Binding ≤ 10μM
ERBB2-2-E	Receptor Protein-tyrosine Kinase ErbB-2 (cluster #2 Of 3), Eukaryotic	Eukaryotes	870	0.29	Binding ≤ 10μM
ERBB4-1-E	Receptor Protein-tyrosine Kinase ErbB-4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1130	0.29	Binding ≤ 10μM
FGFR2-1-E	Fibroblast Growth Factor Receptor 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1900	0.28	Binding ≤ 10μM
FGR-1-E	Tyrosine-protein Kinase FGR (cluster #1 Of 2), Eukaryotic	Eukaryotes	1100	0.29	Binding ≤ 10μM
FLT3-1-E	Tyrosine-protein Kinase Receptor FLT3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	820	0.29	Binding ≤ 10μM
FRK-1-E	Tyrosine-protein Kinase FRK (cluster #1 Of 1), Eukaryotic	Eukaryotes	2000	0.28	Binding ≤ 10μM
GAK-1-E	Serine/threonine-protein Kinase GAK (cluster #1 Of 2), Eukaryotic	Eukaryotes	40	0.36	Binding ≤ 10μM
HCK-1-E	Tyrosine-protein Kinase HCK (cluster #1 Of 1), Eukaryotic	Eukaryotes	1800	0.28	Binding ≤ 10μM
JAK3-2-E	Tyrosine-protein Kinase JAK3 (cluster #2 Of 2), Eukaryotic	Eukaryotes	930	0.29	Binding ≤ 10μM
KC1D-1-E	Casein Kinase I Delta (cluster #1 Of 1), Eukaryotic	Eukaryotes	3500	0.26	Binding ≤ 10μM
KIT-1-E	Stem Cell Growth Factor Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	3100	0.27	Binding ≤ 10μM
KS6A4-1-E	Ribosomal Protein S6 Kinase Alpha 4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	7000	0.25	Binding ≤ 10μM
LCK-1-E	Tyrosine-protein Kinase LCK (cluster #1 Of 4), Eukaryotic	Eukaryotes	530	0.30	Binding ≤ 10μM
LTK-1-E	Leukocyte Tyrosine Kinase Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	890	0.29	Binding ≤ 10μM
LYN-1-E	Tyrosine-protein Kinase Lyn (cluster #1 Of 1), Eukaryotic	Eukaryotes	530	0.30	Binding ≤ 10μM
MET-1-E	Hepatocyte Growth Factor Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	3800	0.26	Binding ≤ 10μM
MK04-1-E	Mitogen-activated Protein Kinase 4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	2500	0.27	Binding ≤ 10μM
MK09-1-E	C-Jun N-terminal Kinase 2 (cluster #1 Of 3), Eukaryotic	Eukaryotes	4000	0.26	Binding ≤ 10μM
MKNK1-1-E	MAP Kinase-interacting Serine/threonine-protein Kinase MNK1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	690	0.30	Binding ≤ 10μM
MKNK2-1-E	MAP Kinase Signal-integrating Kinase 2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	1600	0.28	Binding ≤ 10μM
MRCKG-1-E	Serine/threonine-protein Kinase MRCK Gamma (cluster #1 Of 1), Eukaryotic	Eukaryotes	3400	0.26	Binding ≤ 10μM
MYLK2-1-E	Myosin Light Chain Kinase 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	970	0.29	Binding ≤ 10μM
PGFRA-1-E	Platelet-derived Growth Factor Receptor Alpha (cluster #1 Of 2), Eukaryotic	Eukaryotes	1800	0.28	Binding ≤ 10μM
PGFRB-1-E	Platelet-derived Growth Factor Receptor Beta (cluster #1 Of 1), Eukaryotic	Eukaryotes	1400	0.28	Binding ≤ 10μM
RET-1-E	Tyrosine-protein Kinase Receptor RET (cluster #1 Of 1), Eukaryotic	Eukaryotes	330	0.31	Binding ≤ 10μM
RIPK2-1-E	Serine/threonine-protein Kinase RIPK2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	680	0.30	Binding ≤ 10μM
SLK-1-E	Serine/threonine-protein Kinase 2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	26	0.37	Binding ≤ 10μM
SRC-1-E	Tyrosine-protein Kinase SRC (cluster #1 Of 3), Eukaryotic	Eukaryotes	700	0.30	Binding ≤ 10μM
STK10-1-E	Serine/threonine-protein Kinase 10 (cluster #1 Of 1), Eukaryotic	Eukaryotes	83	0.34	Binding ≤ 10μM
TBA1A-2-E	Tubulin Alpha-3 Chain (cluster #2 Of 3), Eukaryotic	Eukaryotes	230	0.32	Binding ≤ 10μM
TIE1-1-E	Tyrosine-protein Kinase Receptor Tie-1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	850	0.29	Binding ≤ 10μM
TNI3K-1-E	Serine/threonine-protein Kinase TNNI3K (cluster #1 Of 1), Eukaryotic	Eukaryotes	570	0.30	Binding ≤ 10μM
TNK1-1-E	Non-receptor Tyrosine-protein Kinase TNK1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	630	0.30	Binding ≤ 10μM
TYRO3-1-E	Tyrosine-protein Kinase Receptor TYRO3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	3900	0.26	Binding ≤ 10μM
ULK3-1-E	Serine/threonine-protein Kinase ULK3 (cluster #1 Of 2), Eukaryotic	Eukaryotes	630	0.30	Binding ≤ 10μM
VGFR1-1-E	Vascular Endothelial Growth Factor Receptor 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	4400	0.26	Binding ≤ 10μM
VGFR3-1-E	Vascular Endothelial Growth Factor Receptor 3 (cluster #1 Of 2), Eukaryotic	Eukaryotes	2100	0.27	Binding ≤ 10μM
YES-1-E	Tyrosine-protein Kinase YES (cluster #1 Of 1), Eukaryotic	Eukaryotes	2200	0.27	Binding ≤ 10μM
EGFR-1-E	Epidermal Growth Factor Receptor ErbB1 (cluster #1 Of 2), Eukaryotic	Eukaryotes	19	0.37	Functional ≤ 10μM
ERBB2-2-E	Receptor Protein-tyrosine Kinase ErbB-2 (cluster #2 Of 3), Eukaryotic	Eukaryotes	299	0.31	Functional ≤ 10μM
Z103205-1-O	A431 (cluster #1 Of 4), Other	Other	96	0.34	Functional ≤ 10μM
Z103348-1-O	NCI-H2122 (cluster #1 Of 2), Other	Other	1000	0.29	Functional ≤ 10μM
Z80224-1-O	MCF7 (Breast Carcinoma Cells) (cluster #1 Of 14), Other	Other	20	0.37	Functional ≤ 10μM
Z80322-2-O	NCI-H358 (Lung Carcinama Cells) (cluster #2 Of 2), Other	Other	6000	0.25	Functional ≤ 10μM
Z80475-3-O	SK-BR-3 (Breast Adenocarcinoma) (cluster #3 Of 3), Other	Other	1560	0.28	Functional ≤ 10μM
Z80682-1-O	A549 (Lung Carcinoma Cells) (cluster #1 Of 11), Other	Other	270	0.32	Functional ≤ 10μM
Z81020-7-O	HepG2 (Hepatoblastoma Cells) (cluster #7 Of 8), Other	Other	80	0.34	Functional ≤ 10μM
Z81072-6-O	Jurkat (Acute Leukemic T-cells) (cluster #6 Of 10), Other	Other	2000	0.28	Functional ≤ 10μM

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	2.80	9.59	-15.77	1	7	0	75	393.443	10	↓ MOL2 SDF SMILES Flexibase

3820040

Analogs

13125756

Draw Identity 99% 90% 80% 70%

Popular Name: VX-680 VX-680

Find On: PubMed — Wikipedia — Google

Vendors

Active BioPharma
- 5
Capot Chemical
- 22451

Activity (Go SEA)

Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
AAK1-1-E	Adaptor-associated Kinase (cluster #1 Of 2), Eukaryotic	Eukaryotes	290	0.28	Binding ≤ 10μM
AAPK1-1-E	AMP-activated Protein Kinase, Alpha-1 Subunit (cluster #1 Of 1), Eukaryotic	Eukaryotes	1100	0.25	Binding ≤ 10μM
AAPK2-1-E	AMP-activated Protein Kinase, Alpha-2 Subunit (cluster #1 Of 1), Eukaryotic	Eukaryotes	350	0.27	Binding ≤ 10μM
ABL1-1-E	Tyrosine-protein Kinase ABL (cluster #1 Of 1), Eukaryotic	Eukaryotes	9	0.34	Binding ≤ 10μM
ABL2-1-E	Tyrosine-protein Kinase ABL2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	4	0.36	Binding ≤ 10μM
ACK1-1-E	Tyrosine Kinase Non-receptor Protein 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	4400	0.23	Binding ≤ 10μM
ACVR1-1-E	Activin Receptor Type-1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1900	0.24	Binding ≤ 10μM
AKIP-1-E	Aurora Kinase A-interacting Protein (cluster #1 Of 1), Eukaryotic	Eukaryotes	1	0.38	Binding ≤ 10μM
ALK-1-E	ALK Tyrosine Kinase Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	3100	0.23	Binding ≤ 10μM
ANKK1-1-E	Ankyrin Repeat And Protein Kinase Domain-containing Protein 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	5600	0.22	Binding ≤ 10μM
AURKA-1-E	Serine/threonine-protein Kinase Aurora-A (cluster #1 Of 3), Eukaryotic	Eukaryotes	6	0.35	Binding ≤ 10μM
AURKB-1-E	Serine/threonine-protein Kinase Aurora-B (cluster #1 Of 2), Eukaryotic	Eukaryotes	740	0.26	Binding ≤ 10μM
AURKC-1-E	Serine/threonine-protein Kinase Aurora-C (cluster #1 Of 2), Eukaryotic	Eukaryotes	70	0.30	Binding ≤ 10μM
BLK-1-E	Tyrosine-protein Kinase BLK (cluster #1 Of 1), Eukaryotic	Eukaryotes	2200	0.24	Binding ≤ 10μM
BMP2K-1-E	BMP-2-inducible Protein Kinase (cluster #1 Of 2), Eukaryotic	Eukaryotes	65	0.30	Binding ≤ 10μM
BMPR2-1-E	Bone Morphogenetic Protein Receptor Type-2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	7100	0.22	Binding ≤ 10μM
BMX-1-E	Tyrosine-protein Kinase BMX (cluster #1 Of 1), Eukaryotic	Eukaryotes	2600	0.24	Binding ≤ 10μM
BTK-1-E	Tyrosine-protein Kinase BTK (cluster #1 Of 1), Eukaryotic	Eukaryotes	4400	0.23	Binding ≤ 10μM
CD11A-1-E	PITSLRE Serine/threonine-protein Kinase CDC2L2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	260	0.28	Binding ≤ 10μM
CD11B-1-E	PITSLRE Serine/threonine-protein Kinase CDC2L1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	290	0.28	Binding ≤ 10μM
CDK16-1-E	Serine/threonine-protein Kinase PCTAIRE-1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	230	0.28	Binding ≤ 10μM
CSF1R-1-E	Macrophage Colony-stimulating Factor 1 Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	1800	0.24	Binding ≤ 10μM
CSK-1-E	Tyrosine-protein Kinase CSK (cluster #1 Of 1), Eukaryotic	Eukaryotes	4800	0.23	Binding ≤ 10μM
CSK21-1-E	Casein Kinase II Alpha (cluster #1 Of 3), Eukaryotic	Eukaryotes	400	0.27	Binding ≤ 10μM
CSK22-1-E	Casein Kinase II Alpha (prime) (cluster #1 Of 2), Eukaryotic	Eukaryotes	400	0.27	Binding ≤ 10μM
DAPK3-1-E	Death-associated Protein Kinase 3 (cluster #1 Of 2), Eukaryotic	Eukaryotes	190	0.29	Binding ≤ 10μM
DCLK3-1-E	Serine/threonine-protein Kinase DCLK3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	3600	0.23	Binding ≤ 10μM
DDR1-1-E	Epithelial Discoidin Domain-containing Receptor 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	28	0.32	Binding ≤ 10μM
DDR2-1-E	Discoidin Domain-containing Receptor 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	230	0.28	Binding ≤ 10μM
E2AK4-1-E	Eukaryotic Translation Initiation Factor 2-alpha Kinase 4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1900	0.24	Binding ≤ 10μM
EPHA1-1-E	Ephrin Type-A Receptor 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1000	0.25	Binding ≤ 10μM
EPHA2-1-E	Ephrin Type-A Receptor 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	840	0.26	Binding ≤ 10μM
EPHA3-1-E	Ephrin Type-A Receptor 3 (cluster #1 Of 2), Eukaryotic	Eukaryotes	1500	0.25	Binding ≤ 10μM
EPHA4-1-E	Ephrin Type-A Receptor 4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	4300	0.23	Binding ≤ 10μM
EPHA8-1-E	Ephrin Type-A Receptor 8 (cluster #1 Of 1), Eukaryotic	Eukaryotes	500	0.27	Binding ≤ 10μM
EPHB1-1-E	Ephrin Type-B Receptor 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1900	0.24	Binding ≤ 10μM
EPHB4-1-E	Ephrin Type-B Receptor 4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1700	0.24	Binding ≤ 10μM
FAK2-1-E	Protein-tyrosine Kinase 2-beta (cluster #1 Of 1), Eukaryotic	Eukaryotes	2600	0.24	Binding ≤ 10μM
FGFR1-1-E	Fibroblast Growth Factor Receptor 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	550	0.27	Binding ≤ 10μM
FGFR2-1-E	Fibroblast Growth Factor Receptor 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	570	0.26	Binding ≤ 10μM
FGFR3-1-E	Fibroblast Growth Factor Receptor 3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	860	0.26	Binding ≤ 10μM
FGFR4-1-E	Fibroblast Growth Factor Receptor 4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	7200	0.22	Binding ≤ 10μM
FGR-1-E	Tyrosine-protein Kinase FGR (cluster #1 Of 2), Eukaryotic	Eukaryotes	790	0.26	Binding ≤ 10μM
FLT3-1-E	Tyrosine-protein Kinase Receptor FLT3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	7	0.35	Binding ≤ 10μM
FRK-1-E	Tyrosine-protein Kinase FRK (cluster #1 Of 1), Eukaryotic	Eukaryotes	3800	0.23	Binding ≤ 10μM
FYN-1-E	Tyrosine-protein Kinase FYN (cluster #1 Of 5), Eukaryotic	Eukaryotes	530	0.27	Binding ≤ 10μM
GAK-1-E	Serine/threonine-protein Kinase GAK (cluster #1 Of 2), Eukaryotic	Eukaryotes	3200	0.23	Binding ≤ 10μM
IGF1R-1-E	Insulin-like Growth Factor 1 Receptor (cluster #1 Of 2), Eukaryotic	Eukaryotes	740	0.26	Binding ≤ 10μM
IKKE-1-E	Inhibitor Of Nuclear Factor Kappa B Kinase Epsilon Subunit (cluster #1 Of 1), Eukaryotic	Eukaryotes	2600	0.24	Binding ≤ 10μM
INSR-1-E	Insulin Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	630	0.26	Binding ≤ 10μM
INSRR-1-E	Insulin Receptor-related Protein (cluster #1 Of 1), Eukaryotic	Eukaryotes	290	0.28	Binding ≤ 10μM
IRAK3-1-E	Interleukin-1 Receptor-associated Kinase 3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	5600	0.22	Binding ≤ 10μM
ITK-1-E	Tyrosine-protein Kinase ITK/TSK (cluster #1 Of 1), Eukaryotic	Eukaryotes	350	0.27	Binding ≤ 10μM
JAK2-1-E	Tyrosine-protein Kinase JAK2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	190	0.29	Binding ≤ 10μM
JAK3-1-E	Tyrosine-protein Kinase JAK3 (cluster #1 Of 2), Eukaryotic	Eukaryotes	630	0.26	Binding ≤ 10μM
KCC1D-1-E	CaM Kinase I Delta (cluster #1 Of 2), Eukaryotic	Eukaryotes	4900	0.23	Binding ≤ 10μM
KIT-1-E	Stem Cell Growth Factor Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	430	0.27	Binding ≤ 10μM
KS6A2-1-E	Ribosomal Protein S6 Kinase Alpha 2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	2000	0.24	Binding ≤ 10μM
KS6A3-1-E	Ribosomal Protein S6 Kinase Alpha 3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	6400	0.22	Binding ≤ 10μM
KSYK-1-E	Tyrosine-protein Kinase SYK (cluster #1 Of 2), Eukaryotic	Eukaryotes	1800	0.24	Binding ≤ 10μM
LATS1-1-E	Serine/threonine-protein Kinase LATS1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	5500	0.22	Binding ≤ 10μM
LCK-1-E	Tyrosine-protein Kinase LCK (cluster #1 Of 4), Eukaryotic	Eukaryotes	80	0.30	Binding ≤ 10μM
LIMK1-1-E	LIM Domain Kinase 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	2600	0.24	Binding ≤ 10μM
LIMK2-1-E	LIM Domain Kinase 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	2600	0.24	Binding ≤ 10μM
LTK-1-E	Leukocyte Tyrosine Kinase Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	7500	0.22	Binding ≤ 10μM
LYN-1-E	Tyrosine-protein Kinase Lyn (cluster #1 Of 1), Eukaryotic	Eukaryotes	650	0.26	Binding ≤ 10μM
M3K10-1-E	Mitogen-activated Protein Kinase Kinase Kinase 10 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1800	0.24	Binding ≤ 10μM
M3K11-1-E	Mitogen-activated Protein Kinase Kinase Kinase 11 (cluster #1 Of 1), Eukaryotic	Eukaryotes	680	0.26	Binding ≤ 10μM
M3K4-1-E	Mitogen-activated Protein Kinase Kinase Kinase 4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	2500	0.24	Binding ≤ 10μM
M3K9-1-E	Mitogen-activated Protein Kinase Kinase Kinase 9 (cluster #1 Of 1), Eukaryotic	Eukaryotes	390	0.27	Binding ≤ 10μM
M4K1-1-E	Mitogen-activated Protein Kinase Kinase Kinase Kinase 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	72	0.30	Binding ≤ 10μM
M4K3-1-E	Mitogen-activated Protein Kinase Kinase Kinase Kinase 3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	290	0.28	Binding ≤ 10μM
M4K4-1-E	Mitogen-activated Protein Kinase Kinase Kinase Kinase 4 (cluster #1 Of 2), Eukaryotic	Eukaryotes	2400	0.24	Binding ≤ 10μM
M4K5-1-E	Mitogen-activated Protein Kinase Kinase Kinase Kinase 5 (cluster #1 Of 1), Eukaryotic	Eukaryotes	83	0.30	Binding ≤ 10μM
MARK1-1-E	Serine/threonine-protein Kinase MARK1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	4900	0.23	Binding ≤ 10μM
MARK2-1-E	MAP/microtubule Affinity-regulating Kinase 2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	1400	0.25	Binding ≤ 10μM
MARK3-1-E	Serine/threonine-protein Kinase C-TAK1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	2500	0.24	Binding ≤ 10μM
MARK4-1-E	MAP/microtubule Affinity-regulating Kinase 4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	4900	0.23	Binding ≤ 10μM
MELK-1-E	Maternal Embryonic Leucine Zipper Kinase (cluster #1 Of 1), Eukaryotic	Eukaryotes	420	0.27	Binding ≤ 10μM
MERTK-1-E	Proto-oncogene Tyrosine-protein Kinase MER (cluster #1 Of 1), Eukaryotic	Eukaryotes	1700	0.24	Binding ≤ 10μM
MET-1-E	Hepatocyte Growth Factor Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	670	0.26	Binding ≤ 10μM
MK10-1-E	C-Jun N-terminal Kinase 3 (cluster #1 Of 2), Eukaryotic	Eukaryotes	2800	0.24	Binding ≤ 10μM
MLTK-1-E	Mixed Lineage Kinase 7 (cluster #1 Of 1), Eukaryotic	Eukaryotes	2800	0.24	Binding ≤ 10μM
MP2K1-1-E	Dual Specificity Mitogen-activated Protein Kinase Kinase 1 (cluster #1 Of 4), Eukaryotic	Eukaryotes	1800	0.24	Binding ≤ 10μM
MP2K2-1-E	Dual Specificity Mitogen-activated Protein Kinase Kinase 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	2000	0.24	Binding ≤ 10μM
MP2K6-1-E	Dual Specificity Mitogen-activated Protein Kinase Kinase 6 (cluster #1 Of 1), Eukaryotic	Eukaryotes	2600	0.24	Binding ≤ 10μM
MUSK-1-E	Muscle, Skeletal Receptor Tyrosine Protein Kinase (cluster #1 Of 1), Eukaryotic	Eukaryotes	300	0.28	Binding ≤ 10μM
MYLK-1-E	Myosin Light Chain Kinase, Smooth Muscle (cluster #1 Of 1), Eukaryotic	Eukaryotes	15	0.33	Binding ≤ 10μM
MYLK2-1-E	Myosin Light Chain Kinase 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	43	0.31	Binding ≤ 10μM
MYLK4-1-E	Myosin Light Chain Kinase Family Member 4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	2200	0.24	Binding ≤ 10μM
NEK5-1-E	Serine/threonine-protein Kinase Nek5 (cluster #1 Of 1), Eukaryotic	Eukaryotes	4200	0.23	Binding ≤ 10μM
NTRK1-1-E	Nerve Growth Factor Receptor Trk-A (cluster #1 Of 1), Eukaryotic	Eukaryotes	38	0.31	Binding ≤ 10μM
NTRK2-1-E	Neurotrophic Tyrosine Kinase Receptor Type 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	240	0.28	Binding ≤ 10μM
NTRK3-1-E	NT-3 Growth Factor Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	200	0.28	Binding ≤ 10μM
NUAK1-1-E	NUAK Family SNF1-like Kinase 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	200	0.28	Binding ≤ 10μM
NUAK2-1-E	NUAK Family SNF1-like Kinase 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	530	0.27	Binding ≤ 10μM
PAK1-1-E	Serine/threonine-protein Kinase PAK 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	4400	0.23	Binding ≤ 10μM
PAK2-1-E	Serine/threonine-protein Kinase PAK 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	5700	0.22	Binding ≤ 10μM
PAK3-1-E	Serine/threonine-protein Kinase PAK 3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	3300	0.23	Binding ≤ 10μM
PAK4-1-E	Serine/threonine-protein Kinase PAK 4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	4300	0.23	Binding ≤ 10μM
PAK7-1-E	Serine/threonine-protein Kinase PAK7 (cluster #1 Of 1), Eukaryotic	Eukaryotes	3300	0.23	Binding ≤ 10μM
PGFRA-1-E	Platelet-derived Growth Factor Receptor Alpha (cluster #1 Of 2), Eukaryotic	Eukaryotes	1600	0.25	Binding ≤ 10μM
PGFRB-1-E	Platelet-derived Growth Factor Receptor Beta (cluster #1 Of 1), Eukaryotic	Eukaryotes	310	0.28	Binding ≤ 10μM
PHKG1-1-E	Phosphorylase Kinase Gamma Subunit 1 (cluster #1 Of 2), Eukaryotic	Eukaryotes	2200	0.24	Binding ≤ 10μM
PI42B-1-E	Phosphatidylinositol-5-phosphate 4-kinase Type-2 Beta (cluster #1 Of 1), Eukaryotic	Eukaryotes	140	0.29	Binding ≤ 10μM
PI51A-1-E	Phosphatidylinositol-4-phosphate 5-kinase Type-1 Alpha (cluster #1 Of 1), Eukaryotic	Eukaryotes	130	0.29	Binding ≤ 10μM
PKN1-1-E	Protein Kinase N1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1500	0.25	Binding ≤ 10μM
PLK4-1-E	Serine/threonine-protein Kinase PLK4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	9	0.34	Binding ≤ 10μM
RET-1-E	Tyrosine-protein Kinase Receptor RET (cluster #1 Of 1), Eukaryotic	Eukaryotes	28	0.32	Binding ≤ 10μM
RIOK1-1-E	Serine/threonine-protein Kinase RIO1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	360	0.27	Binding ≤ 10μM
RIOK3-1-E	Serine/threonine-protein Kinase RIO3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	600	0.26	Binding ≤ 10μM
RIPK1-1-E	Receptor-interacting Serine/threonine-protein Kinase 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	20	0.33	Binding ≤ 10μM
ROS1-1-E	Proto-oncogene Tyrosine-protein Kinase ROS (cluster #1 Of 1), Eukaryotic	Eukaryotes	610	0.26	Binding ≤ 10μM
SIK1-1-E	Serine/threonine-protein Kinase SIK1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	2500	0.24	Binding ≤ 10μM
SIK2-1-E	Serine/threonine-protein Kinase SIK2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1700	0.24	Binding ≤ 10μM
SLK-1-E	Serine/threonine-protein Kinase 2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	82	0.30	Binding ≤ 10μM
SRC-1-E	Tyrosine-protein Kinase SRC (cluster #1 Of 3), Eukaryotic	Eukaryotes	170	0.29	Binding ≤ 10μM
SRPK1-1-E	Serine/threonine-protein Kinase SRPK1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	82	0.30	Binding ≤ 10μM
SRPK2-1-E	Serine/threonine-protein Kinase SRPK2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	680	0.26	Binding ≤ 10μM
STK10-1-E	Serine/threonine-protein Kinase 10 (cluster #1 Of 1), Eukaryotic	Eukaryotes	120	0.29	Binding ≤ 10μM
STK11-1-E	Serine/threonine-protein Kinase 11 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1300	0.25	Binding ≤ 10μM
STK16-1-E	Serine/threonine-protein Kinase 16 (cluster #1 Of 1), Eukaryotic	Eukaryotes	610	0.26	Binding ≤ 10μM
STK24-1-E	Serine/threonine-protein Kinase 24 (cluster #1 Of 1), Eukaryotic	Eukaryotes	3600	0.23	Binding ≤ 10μM
STK25-1-E	Serine/threonine-protein Kinase 25 (cluster #1 Of 1), Eukaryotic	Eukaryotes	4800	0.23	Binding ≤ 10μM
STK3-1-E	Serine/threonine-protein Kinase MST2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	510	0.27	Binding ≤ 10μM
STK4-1-E	Serine/threonine-protein Kinase MST1 (cluster #1 Of 2), Eukaryotic	Eukaryotes	200	0.28	Binding ≤ 10μM
TESK1-1-E	Dual Specificity Testis-specific Protein Kinase 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	5600	0.22	Binding ≤ 10μM
TIE1-1-E	Tyrosine-protein Kinase Receptor Tie-1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	270	0.28	Binding ≤ 10μM
TIE2-1-E	Tyrosine-protein Kinase TIE-2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	450	0.27	Binding ≤ 10μM
TNIK-1-E	TRAF2- And NCK-interacting Kinase (cluster #1 Of 2), Eukaryotic	Eukaryotes	1800	0.24	Binding ≤ 10μM
TNK1-1-E	Non-receptor Tyrosine-protein Kinase TNK1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	85	0.30	Binding ≤ 10μM
TXK-1-E	Tyrosine-protein Kinase TXK (cluster #1 Of 1), Eukaryotic	Eukaryotes	2700	0.24	Binding ≤ 10μM
UFO-1-E	Tyrosine-protein Kinase Receptor UFO (cluster #1 Of 1), Eukaryotic	Eukaryotes	210	0.28	Binding ≤ 10μM
VGFR1-1-E	Vascular Endothelial Growth Factor Receptor 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	100	0.30	Binding ≤ 10μM
VGFR2-1-E	Vascular Endothelial Growth Factor Receptor 2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	2000	0.24	Binding ≤ 10μM
VGFR3-1-E	Vascular Endothelial Growth Factor Receptor 3 (cluster #1 Of 2), Eukaryotic	Eukaryotes	1900	0.24	Binding ≤ 10μM
WEE1-1-E	Serine/threonine-protein Kinase WEE1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	3200	0.23	Binding ≤ 10μM
YES-1-E	Tyrosine-protein Kinase YES (cluster #1 Of 1), Eukaryotic	Eukaryotes	470	0.27	Binding ≤ 10μM
Z80166-4-O	HT-29 (Colon Adenocarcinoma Cells) (cluster #4 Of 12), Other	Other	150	0.29	Functional ≤ 10μM
Z80224-1-O	MCF7 (Breast Carcinoma Cells) (cluster #1 Of 14), Other	Other	48	0.31	Functional ≤ 10μM
Z80928-3-O	HCT-116 (Colon Carcinoma Cells) (cluster #3 Of 9), Other	Other	53	0.31	Functional ≤ 10μM

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	3.69	-6.09	-47.27	4	9	1	103	465.607	7	↓ MOL2 SDF SMILES Flexibase

18825339

Analogs

Draw Identity 99% 90% 80% 70%

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Vendors

Ark Pharm Building Blocks
- AK-43241

Activity (Go SEA)

Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
AAK1-1-E	Adaptor-associated Kinase (cluster #1 Of 2), Eukaryotic	Eukaryotes	66	0.31	Binding ≤ 10μM
AAPK1-1-E	AMP-activated Protein Kinase, Alpha-1 Subunit (cluster #1 Of 1), Eukaryotic	Eukaryotes	100	0.31	Binding ≤ 10μM
AAPK2-1-E	AMP-activated Protein Kinase, Alpha-2 Subunit (cluster #1 Of 1), Eukaryotic	Eukaryotes	290	0.29	Binding ≤ 10μM
ABL1-1-E	Tyrosine-protein Kinase ABL (cluster #1 Of 1), Eukaryotic	Eukaryotes	970	0.26	Binding ≤ 10μM
ACK1-1-E	Tyrosine Kinase Non-receptor Protein 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	4900	0.23	Binding ≤ 10μM
ALK-1-E	ALK Tyrosine Kinase Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	490	0.28	Binding ≤ 10μM
ANKK1-1-E	Ankyrin Repeat And Protein Kinase Domain-containing Protein 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	160	0.30	Binding ≤ 10μM
AURKB-1-E	Serine/threonine-protein Kinase Aurora-B (cluster #1 Of 2), Eukaryotic	Eukaryotes	340	0.28	Binding ≤ 10μM
AURKC-1-E	Serine/threonine-protein Kinase Aurora-C (cluster #1 Of 2), Eukaryotic	Eukaryotes	810	0.27	Binding ≤ 10μM
BLK-1-E	Tyrosine-protein Kinase BLK (cluster #1 Of 1), Eukaryotic	Eukaryotes	750	0.27	Binding ≤ 10μM
BMP2K-1-E	BMP-2-inducible Protein Kinase (cluster #1 Of 2), Eukaryotic	Eukaryotes	27	0.33	Binding ≤ 10μM
BMPR2-1-E	Bone Morphogenetic Protein Receptor Type-2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	200	0.29	Binding ≤ 10μM
BRSK1-1-E	BR Serine/threonine-protein Kinase 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	5000	0.23	Binding ≤ 10μM
BRSK2-1-E	BR Serine/threonine-protein Kinase 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	4100	0.24	Binding ≤ 10μM
CDK16-1-E	Serine/threonine-protein Kinase PCTAIRE-1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	940	0.26	Binding ≤ 10μM
CDK7-1-E	Cyclin-dependent Kinase 7 (cluster #1 Of 1), Eukaryotic	Eukaryotes	930	0.26	Binding ≤ 10μM
CHK1-1-E	Serine/threonine-protein Kinase Chk1 (cluster #1 Of 2), Eukaryotic	Eukaryotes	1200	0.26	Binding ≤ 10μM
CLK1-1-E	Dual Specificty Protein Kinase CLK1 (cluster #1 Of 2), Eukaryotic	Eukaryotes	360	0.28	Binding ≤ 10μM
CLK2-1-E	Dual Specificity Protein Kinase CLK2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	150	0.30	Binding ≤ 10μM
CLK4-1-E	Dual Specificity Protein Kinase CLK4 (cluster #1 Of 2), Eukaryotic	Eukaryotes	250	0.29	Binding ≤ 10μM
CSF1R-1-E	Macrophage Colony-stimulating Factor 1 Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	4	0.37	Binding ≤ 10μM
CSK21-1-E	Casein Kinase II Alpha (cluster #1 Of 3), Eukaryotic	Eukaryotes	97	0.31	Binding ≤ 10μM
CSK22-1-E	Casein Kinase II Alpha (prime) (cluster #1 Of 2), Eukaryotic	Eukaryotes	140	0.30	Binding ≤ 10μM
CTRO-1-E	Citron Rho-interacting Kinase (cluster #1 Of 1), Eukaryotic	Eukaryotes	94	0.31	Binding ≤ 10μM
DAPK1-1-E	Death-associated Protein Kinase 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	270	0.29	Binding ≤ 10μM
DAPK2-1-E	Death-associated Protein Kinase 2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	400	0.28	Binding ≤ 10μM
DAPK3-1-E	Death-associated Protein Kinase 3 (cluster #1 Of 2), Eukaryotic	Eukaryotes	560	0.27	Binding ≤ 10μM
DCLK1-1-E	Serine/threonine-protein Kinase DCLK1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	550	0.27	Binding ≤ 10μM
DCLK3-1-E	Serine/threonine-protein Kinase DCLK3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	240	0.29	Binding ≤ 10μM
DYR1B-1-E	Dual Specificity Tyrosine-phosphorylation-regulated Kinase 1B (cluster #1 Of 1), Eukaryotic	Eukaryotes	2600	0.24	Binding ≤ 10μM
E2AK2-1-E	Interferon-induced, Double-stranded RNA-activated Protein Kinase (cluster #1 Of 1), Eukaryotic	Eukaryotes	1300	0.26	Binding ≤ 10μM
E2AK4-1-E	Eukaryotic Translation Initiation Factor 2-alpha Kinase 4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	470	0.28	Binding ≤ 10μM
EGFR-1-E	Epidermal Growth Factor Receptor ErbB1 (cluster #1 Of 4), Eukaryotic	Eukaryotes	9000	0.22	Binding ≤ 10μM
EPHA6-1-E	Ephrin Type-A Receptor 6 (cluster #1 Of 1), Eukaryotic	Eukaryotes	2000	0.25	Binding ≤ 10μM
FAK1-1-E	Focal Adhesion Kinase 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1200	0.26	Binding ≤ 10μM
FAK2-1-E	Protein-tyrosine Kinase 2-beta (cluster #1 Of 1), Eukaryotic	Eukaryotes	600	0.27	Binding ≤ 10μM
FER-1-E	Tyrosine-protein Kinase FER (cluster #1 Of 1), Eukaryotic	Eukaryotes	34	0.33	Binding ≤ 10μM
FGFR1-1-E	Fibroblast Growth Factor Receptor 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1900	0.25	Binding ≤ 10μM
FGFR2-1-E	Fibroblast Growth Factor Receptor 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	790	0.27	Binding ≤ 10μM
FGFR3-1-E	Fibroblast Growth Factor Receptor 3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	560	0.27	Binding ≤ 10μM
FGR-1-E	Tyrosine-protein Kinase FGR (cluster #1 Of 2), Eukaryotic	Eukaryotes	390	0.28	Binding ≤ 10μM
FLT3-1-E	Tyrosine-protein Kinase Receptor FLT3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	6	0.36	Binding ≤ 10μM
FYN-1-E	Tyrosine-protein Kinase FYN (cluster #1 Of 5), Eukaryotic	Eukaryotes	2600	0.24	Binding ≤ 10μM
GAK-1-E	Serine/threonine-protein Kinase GAK (cluster #1 Of 2), Eukaryotic	Eukaryotes	44	0.32	Binding ≤ 10μM
HCK-1-E	Tyrosine-protein Kinase HCK (cluster #1 Of 1), Eukaryotic	Eukaryotes	2200	0.25	Binding ≤ 10μM
IKKE-1-E	Inhibitor Of Nuclear Factor Kappa B Kinase Epsilon Subunit (cluster #1 Of 1), Eukaryotic	Eukaryotes	480	0.28	Binding ≤ 10μM
INSR-1-E	Insulin Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	1200	0.26	Binding ≤ 10μM
INSRR-1-E	Insulin Receptor-related Protein (cluster #1 Of 1), Eukaryotic	Eukaryotes	2000	0.25	Binding ≤ 10μM
IRAK3-1-E	Interleukin-1 Receptor-associated Kinase 3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1900	0.25	Binding ≤ 10μM
ITK-1-E	Tyrosine-protein Kinase ITK/TSK (cluster #1 Of 1), Eukaryotic	Eukaryotes	190	0.29	Binding ≤ 10μM
JAK1-1-E	Tyrosine-protein Kinase JAK1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	97	0.31	Binding ≤ 10μM
JAK2-1-E	Tyrosine-protein Kinase JAK2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1600	0.25	Binding ≤ 10μM
JAK3-1-E	Tyrosine-protein Kinase JAK3 (cluster #1 Of 2), Eukaryotic	Eukaryotes	580	0.27	Binding ≤ 10μM
KC1AL-1-E	Casein Kinase I Isoform Alpha-like (cluster #1 Of 1), Eukaryotic	Eukaryotes	1500	0.25	Binding ≤ 10μM
KC1D-1-E	Casein Kinase I Delta (cluster #1 Of 1), Eukaryotic	Eukaryotes	260	0.29	Binding ≤ 10μM
KC1E-1-E	Casein Kinase I Epsilon (cluster #1 Of 2), Eukaryotic	Eukaryotes	340	0.28	Binding ≤ 10μM
KC1G1-1-E	Casein Kinase I Gamma 1 (cluster #1 Of 2), Eukaryotic	Eukaryotes	1000	0.26	Binding ≤ 10μM
KC1G2-1-E	Casein Kinase I Gamma 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	790	0.27	Binding ≤ 10μM
KC1G3-1-E	Casein Kinase I Isoform Gamma-3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	570	0.27	Binding ≤ 10μM
KCC1A-1-E	CaM Kinase I Alpha (cluster #1 Of 2), Eukaryotic	Eukaryotes	3300	0.24	Binding ≤ 10μM
KCC1D-1-E	CaM Kinase I Delta (cluster #1 Of 2), Eukaryotic	Eukaryotes	970	0.26	Binding ≤ 10μM
KCC1G-1-E	CaM Kinase I Gamma (cluster #1 Of 2), Eukaryotic	Eukaryotes	940	0.26	Binding ≤ 10μM
KCC2A-1-E	CaM Kinase II Alpha (cluster #1 Of 1), Eukaryotic	Eukaryotes	350	0.28	Binding ≤ 10μM
KCC2B-1-E	CaM Kinase II Beta (cluster #1 Of 1), Eukaryotic	Eukaryotes	2300	0.25	Binding ≤ 10μM
KCC2D-1-E	CaM Kinase II Delta (cluster #1 Of 1), Eukaryotic	Eukaryotes	760	0.27	Binding ≤ 10μM
KCC2G-1-E	CaM Kinase II Gamma (cluster #1 Of 1), Eukaryotic	Eukaryotes	1100	0.26	Binding ≤ 10μM
KCC4-1-E	CaM Kinase IV (cluster #1 Of 1), Eukaryotic	Eukaryotes	2700	0.24	Binding ≤ 10μM
KIT-1-E	Stem Cell Growth Factor Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	340	0.28	Binding ≤ 10μM
KKCC1-1-E	CaM-kinase Kinase Alpha (cluster #1 Of 1), Eukaryotic	Eukaryotes	850	0.27	Binding ≤ 10μM
KKCC2-1-E	CaM-kinase Kinase Beta (cluster #1 Of 2), Eukaryotic	Eukaryotes	2500	0.25	Binding ≤ 10μM
KPCD1-1-E	Protein Kinase C Mu (cluster #1 Of 3), Eukaryotic	Eukaryotes	2400	0.25	Binding ≤ 10μM
KPCD2-1-E	Serine/threonine-protein Kinase D2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	3700	0.24	Binding ≤ 10μM
KPCD3-1-E	Protein Kinase C Nu (cluster #1 Of 3), Eukaryotic	Eukaryotes	2700	0.24	Binding ≤ 10μM
KPCT-1-E	Protein Kinase C Theta (cluster #1 Of 3), Eukaryotic	Eukaryotes	7200	0.22	Binding ≤ 10μM
KS6A1-1-E	Ribosomal Protein S6 Kinase Alpha 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	5800	0.23	Binding ≤ 10μM
KS6A2-1-E	Ribosomal Protein S6 Kinase Alpha 2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	9600	0.22	Binding ≤ 10μM
KS6A3-1-E	Ribosomal Protein S6 Kinase Alpha 3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	2100	0.25	Binding ≤ 10μM
KS6A4-1-E	Ribosomal Protein S6 Kinase Alpha 4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	2000	0.25	Binding ≤ 10μM
KS6A5-1-E	Ribosomal Protein S6 Kinase Alpha 5 (cluster #1 Of 3), Eukaryotic	Eukaryotes	1500	0.25	Binding ≤ 10μM
KS6A6-1-E	Ribosomal Protein S6 Kinase Alpha 6 (cluster #1 Of 1), Eukaryotic	Eukaryotes	3100	0.24	Binding ≤ 10μM
LATS1-1-E	Serine/threonine-protein Kinase LATS1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	850	0.27	Binding ≤ 10μM
LATS2-1-E	Serine/threonine-protein Kinase LATS2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	430	0.28	Binding ≤ 10μM
LCK-1-E	Tyrosine-protein Kinase LCK (cluster #1 Of 4), Eukaryotic	Eukaryotes	2300	0.25	Binding ≤ 10μM
LTK-1-E	Leukocyte Tyrosine Kinase Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	4200	0.24	Binding ≤ 10μM
LYN-1-E	Tyrosine-protein Kinase Lyn (cluster #1 Of 1), Eukaryotic	Eukaryotes	810	0.27	Binding ≤ 10μM
M3K11-1-E	Mitogen-activated Protein Kinase Kinase Kinase 11 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1700	0.25	Binding ≤ 10μM
M3K9-1-E	Mitogen-activated Protein Kinase Kinase Kinase 9 (cluster #1 Of 1), Eukaryotic	Eukaryotes	2600	0.24	Binding ≤ 10μM
M4K1-1-E	Mitogen-activated Protein Kinase Kinase Kinase Kinase 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	15	0.34	Binding ≤ 10μM
M4K3-1-E	Mitogen-activated Protein Kinase Kinase Kinase Kinase 3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	210	0.29	Binding ≤ 10μM
M4K4-1-E	Mitogen-activated Protein Kinase Kinase Kinase Kinase 4 (cluster #1 Of 2), Eukaryotic	Eukaryotes	260	0.29	Binding ≤ 10μM
M4K5-1-E	Mitogen-activated Protein Kinase Kinase Kinase Kinase 5 (cluster #1 Of 1), Eukaryotic	Eukaryotes	300	0.29	Binding ≤ 10μM
MARK1-1-E	Serine/threonine-protein Kinase MARK1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1500	0.25	Binding ≤ 10μM
MARK2-1-E	MAP/microtubule Affinity-regulating Kinase 2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	440	0.28	Binding ≤ 10μM
MARK3-1-E	Serine/threonine-protein Kinase C-TAK1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1100	0.26	Binding ≤ 10μM
MARK4-1-E	MAP/microtubule Affinity-regulating Kinase 4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	2000	0.25	Binding ≤ 10μM
MELK-1-E	Maternal Embryonic Leucine Zipper Kinase (cluster #1 Of 1), Eukaryotic	Eukaryotes	340	0.28	Binding ≤ 10μM
MERTK-1-E	Proto-oncogene Tyrosine-protein Kinase MER (cluster #1 Of 1), Eukaryotic	Eukaryotes	66	0.31	Binding ≤ 10μM
MKNK2-1-E	MAP Kinase Signal-integrating Kinase 2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	5500	0.23	Binding ≤ 10μM
MP2K1-1-E	Dual Specificity Mitogen-activated Protein Kinase Kinase 1 (cluster #1 Of 4), Eukaryotic	Eukaryotes	77	0.31	Binding ≤ 10μM
MP2K2-1-E	Dual Specificity Mitogen-activated Protein Kinase Kinase 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	120	0.30	Binding ≤ 10μM
MP2K4-1-E	Dual Specificity Mitogen-activated Protein Kinase Kinase 4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1400	0.26	Binding ≤ 10μM
MP2K6-1-E	Dual Specificity Mitogen-activated Protein Kinase Kinase 6 (cluster #1 Of 1), Eukaryotic	Eukaryotes	5500	0.23	Binding ≤ 10μM
MST4-1-E	Serine/threonine-protein Kinase MST4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	330	0.28	Binding ≤ 10μM
MUSK-1-E	Muscle, Skeletal Receptor Tyrosine Protein Kinase (cluster #1 Of 1), Eukaryotic	Eukaryotes	100	0.31	Binding ≤ 10μM
MYLK-1-E	Myosin Light Chain Kinase, Smooth Muscle (cluster #1 Of 1), Eukaryotic	Eukaryotes	360	0.28	Binding ≤ 10μM
MYLK2-1-E	Myosin Light Chain Kinase 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	190	0.29	Binding ≤ 10μM
MYLK4-1-E	Myosin Light Chain Kinase Family Member 4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	32	0.33	Binding ≤ 10μM
NEK2-1-E	Serine/threonine-protein Kinase NEK2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1100	0.26	Binding ≤ 10μM
NEK7-1-E	Serine/threonine-protein Kinase NEK7 (cluster #1 Of 1), Eukaryotic	Eukaryotes	3200	0.24	Binding ≤ 10μM
NTRK1-1-E	Nerve Growth Factor Receptor Trk-A (cluster #1 Of 1), Eukaryotic	Eukaryotes	480	0.28	Binding ≤ 10μM
NTRK2-1-E	Neurotrophic Tyrosine Kinase Receptor Type 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	990	0.26	Binding ≤ 10μM
NTRK3-1-E	NT-3 Growth Factor Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	220	0.29	Binding ≤ 10μM
NUAK1-1-E	NUAK Family SNF1-like Kinase 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	460	0.28	Binding ≤ 10μM
NUAK2-1-E	NUAK Family SNF1-like Kinase 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	400	0.28	Binding ≤ 10μM
PAK3-1-E	Serine/threonine-protein Kinase PAK 3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	190	0.29	Binding ≤ 10μM
PDPK1-1-E	3-phosphoinositide Dependent Protein Kinase-1 (cluster #1 Of 2), Eukaryotic	Eukaryotes	2600	0.24	Binding ≤ 10μM
PGFRA-1-E	Platelet-derived Growth Factor Receptor Alpha (cluster #1 Of 2), Eukaryotic	Eukaryotes	1	0.39	Binding ≤ 10μM
PGFRB-1-E	Platelet-derived Growth Factor Receptor Beta (cluster #1 Of 1), Eukaryotic	Eukaryotes	0	0.00	Binding ≤ 10μM
PHKG1-1-E	Phosphorylase Kinase Gamma Subunit 1 (cluster #1 Of 2), Eukaryotic	Eukaryotes	83	0.31	Binding ≤ 10μM
PHKG2-1-E	Phosphorylase Kinase Gamma Subunit 2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	100	0.31	Binding ≤ 10μM
PI42B-1-E	Phosphatidylinositol-5-phosphate 4-kinase Type-2 Beta (cluster #1 Of 1), Eukaryotic	Eukaryotes	260	0.29	Binding ≤ 10μM
PI51A-1-E	Phosphatidylinositol-4-phosphate 5-kinase Type-1 Alpha (cluster #1 Of 1), Eukaryotic	Eukaryotes	130	0.30	Binding ≤ 10μM
PIM3-1-E	Serine/threonine-protein Kinase PIM3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	2400	0.25	Binding ≤ 10μM
PKN1-1-E	Protein Kinase N1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1900	0.25	Binding ≤ 10μM
PKN2-1-E	Protein Kinase N2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	3800	0.24	Binding ≤ 10μM
PLK4-1-E	Serine/threonine-protein Kinase PLK4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	180	0.30	Binding ≤ 10μM
RET-1-E	Tyrosine-protein Kinase Receptor RET (cluster #1 Of 1), Eukaryotic	Eukaryotes	37	0.33	Binding ≤ 10μM
RIOK1-1-E	Serine/threonine-protein Kinase RIO1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	590	0.27	Binding ≤ 10μM
RIOK3-1-E	Serine/threonine-protein Kinase RIO3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	9700	0.22	Binding ≤ 10μM
RIPK1-1-E	Receptor-interacting Serine/threonine-protein Kinase 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1200	0.26	Binding ≤ 10μM
SIK1-1-E	Serine/threonine-protein Kinase SIK1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	2700	0.24	Binding ≤ 10μM
SIK2-1-E	Serine/threonine-protein Kinase SIK2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	750	0.27	Binding ≤ 10μM
SLK-1-E	Serine/threonine-protein Kinase 2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	460	0.28	Binding ≤ 10μM
SRC-1-E	Tyrosine-protein Kinase SRC (cluster #1 Of 3), Eukaryotic	Eukaryotes	4900	0.23	Binding ≤ 10μM
SRMS-1-E	Tyrosine-protein Kinase Srms (cluster #1 Of 1), Eukaryotic	Eukaryotes	62	0.32	Binding ≤ 10μM
SRPK1-1-E	Serine/threonine-protein Kinase SRPK1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	4000	0.24	Binding ≤ 10μM
SRPK2-1-E	Serine/threonine-protein Kinase SRPK2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	200	0.29	Binding ≤ 10μM
ST17A-1-E	Serine/threonine-protein Kinase 17A (cluster #1 Of 2), Eukaryotic	Eukaryotes	24	0.33	Binding ≤ 10μM
ST17B-1-E	Serine/threonine-protein Kinase 17B (cluster #1 Of 1), Eukaryotic	Eukaryotes	320	0.28	Binding ≤ 10μM
ST38L-1-E	Serine/threonine-protein Kinase 38-like (cluster #1 Of 2), Eukaryotic	Eukaryotes	2000	0.25	Binding ≤ 10μM
STK10-1-E	Serine/threonine-protein Kinase 10 (cluster #1 Of 1), Eukaryotic	Eukaryotes	230	0.29	Binding ≤ 10μM
STK11-1-E	Serine/threonine-protein Kinase 11 (cluster #1 Of 1), Eukaryotic	Eukaryotes	360	0.28	Binding ≤ 10μM
STK16-1-E	Serine/threonine-protein Kinase 16 (cluster #1 Of 1), Eukaryotic	Eukaryotes	730	0.27	Binding ≤ 10μM
STK24-1-E	Serine/threonine-protein Kinase 24 (cluster #1 Of 1), Eukaryotic	Eukaryotes	100	0.31	Binding ≤ 10μM
STK25-1-E	Serine/threonine-protein Kinase 25 (cluster #1 Of 1), Eukaryotic	Eukaryotes	360	0.28	Binding ≤ 10μM
STK3-1-E	Serine/threonine-protein Kinase MST2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	65	0.31	Binding ≤ 10μM
STK33-1-E	Serine/threonine-protein Kinase 33 (cluster #1 Of 1), Eukaryotic	Eukaryotes	130	0.30	Binding ≤ 10μM
STK4-1-E	Serine/threonine-protein Kinase MST1 (cluster #1 Of 2), Eukaryotic	Eukaryotes	130	0.30	Binding ≤ 10μM
TLK1-1-E	Serine/threonine-protein Kinase Tousled-like 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	630	0.27	Binding ≤ 10μM
TLK2-1-E	Serine/threonine-protein Kinase Tousled-like 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	270	0.29	Binding ≤ 10μM
TNIK-1-E	TRAF2- And NCK-interacting Kinase (cluster #1 Of 2), Eukaryotic	Eukaryotes	90	0.31	Binding ≤ 10μM
TNK1-1-E	Non-receptor Tyrosine-protein Kinase TNK1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1500	0.25	Binding ≤ 10μM
TTK-1-E	Dual Specificity Protein Kinase TTK (cluster #1 Of 2), Eukaryotic	Eukaryotes	180	0.30	Binding ≤ 10μM
TYK2-1-E	Tyrosine-protein Kinase TYK2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	5100	0.23	Binding ≤ 10μM
TYRO3-1-E	Tyrosine-protein Kinase Receptor TYRO3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	2400	0.25	Binding ≤ 10μM
UFO-1-E	Tyrosine-protein Kinase Receptor UFO (cluster #1 Of 1), Eukaryotic	Eukaryotes	84	0.31	Binding ≤ 10μM
VGFR1-1-E	Vascular Endothelial Growth Factor Receptor 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	5	0.36	Binding ≤ 10μM
VGFR2-1-E	Vascular Endothelial Growth Factor Receptor 2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	2	0.38	Binding ≤ 10μM
VGFR3-1-E	Vascular Endothelial Growth Factor Receptor 3 (cluster #1 Of 2), Eukaryotic	Eukaryotes	50	0.32	Binding ≤ 10μM
WEE1-1-E	Serine/threonine-protein Kinase WEE1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	3000	0.24	Binding ≤ 10μM
YES-1-E	Tyrosine-protein Kinase YES (cluster #1 Of 1), Eukaryotic	Eukaryotes	260	0.29	Binding ≤ 10μM

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	0.40	1.85	-15.93	4	8	0	110	442.491	6	↓ MOL2 SDF SMILES Flexibase

18825344

Analogs

Draw Identity 99% 90% 80% 70%

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Vendors

Activity (Go SEA)

Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
AAK1-1-E	Adaptor-associated Kinase (cluster #1 Of 2), Eukaryotic	Eukaryotes	66	0.31	Binding ≤ 10μM
AAPK1-1-E	AMP-activated Protein Kinase, Alpha-1 Subunit (cluster #1 Of 1), Eukaryotic	Eukaryotes	100	0.31	Binding ≤ 10μM
AAPK2-1-E	AMP-activated Protein Kinase, Alpha-2 Subunit (cluster #1 Of 1), Eukaryotic	Eukaryotes	290	0.29	Binding ≤ 10μM
ABL1-1-E	Tyrosine-protein Kinase ABL (cluster #1 Of 1), Eukaryotic	Eukaryotes	970	0.26	Binding ≤ 10μM
ACK1-1-E	Tyrosine Kinase Non-receptor Protein 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	4900	0.23	Binding ≤ 10μM
ALK-1-E	ALK Tyrosine Kinase Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	490	0.28	Binding ≤ 10μM
ANKK1-1-E	Ankyrin Repeat And Protein Kinase Domain-containing Protein 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	160	0.30	Binding ≤ 10μM
AURKB-1-E	Serine/threonine-protein Kinase Aurora-B (cluster #1 Of 2), Eukaryotic	Eukaryotes	340	0.28	Binding ≤ 10μM
AURKC-1-E	Serine/threonine-protein Kinase Aurora-C (cluster #1 Of 2), Eukaryotic	Eukaryotes	810	0.27	Binding ≤ 10μM
BLK-1-E	Tyrosine-protein Kinase BLK (cluster #1 Of 1), Eukaryotic	Eukaryotes	750	0.27	Binding ≤ 10μM
BMP2K-1-E	BMP-2-inducible Protein Kinase (cluster #1 Of 2), Eukaryotic	Eukaryotes	27	0.33	Binding ≤ 10μM
BMPR2-1-E	Bone Morphogenetic Protein Receptor Type-2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	200	0.29	Binding ≤ 10μM
BRSK1-1-E	BR Serine/threonine-protein Kinase 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	5000	0.23	Binding ≤ 10μM
BRSK2-1-E	BR Serine/threonine-protein Kinase 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	4100	0.24	Binding ≤ 10μM
CDK16-1-E	Serine/threonine-protein Kinase PCTAIRE-1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	940	0.26	Binding ≤ 10μM
CDK7-1-E	Cyclin-dependent Kinase 7 (cluster #1 Of 1), Eukaryotic	Eukaryotes	930	0.26	Binding ≤ 10μM
CHK1-1-E	Serine/threonine-protein Kinase Chk1 (cluster #1 Of 2), Eukaryotic	Eukaryotes	1200	0.26	Binding ≤ 10μM
CLK1-1-E	Dual Specificty Protein Kinase CLK1 (cluster #1 Of 2), Eukaryotic	Eukaryotes	360	0.28	Binding ≤ 10μM
CLK2-1-E	Dual Specificity Protein Kinase CLK2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	150	0.30	Binding ≤ 10μM
CLK4-1-E	Dual Specificity Protein Kinase CLK4 (cluster #1 Of 2), Eukaryotic	Eukaryotes	250	0.29	Binding ≤ 10μM
CSF1R-1-E	Macrophage Colony-stimulating Factor 1 Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	4	0.37	Binding ≤ 10μM
CSK21-1-E	Casein Kinase II Alpha (cluster #1 Of 3), Eukaryotic	Eukaryotes	97	0.31	Binding ≤ 10μM
CSK22-1-E	Casein Kinase II Alpha (prime) (cluster #1 Of 2), Eukaryotic	Eukaryotes	140	0.30	Binding ≤ 10μM
CTRO-1-E	Citron Rho-interacting Kinase (cluster #1 Of 1), Eukaryotic	Eukaryotes	94	0.31	Binding ≤ 10μM
DAPK1-1-E	Death-associated Protein Kinase 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	270	0.29	Binding ≤ 10μM
DAPK2-1-E	Death-associated Protein Kinase 2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	400	0.28	Binding ≤ 10μM
DAPK3-1-E	Death-associated Protein Kinase 3 (cluster #1 Of 2), Eukaryotic	Eukaryotes	560	0.27	Binding ≤ 10μM
DCLK1-1-E	Serine/threonine-protein Kinase DCLK1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	550	0.27	Binding ≤ 10μM
DCLK3-1-E	Serine/threonine-protein Kinase DCLK3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	240	0.29	Binding ≤ 10μM
DYR1B-1-E	Dual Specificity Tyrosine-phosphorylation-regulated Kinase 1B (cluster #1 Of 1), Eukaryotic	Eukaryotes	2600	0.24	Binding ≤ 10μM
E2AK2-1-E	Interferon-induced, Double-stranded RNA-activated Protein Kinase (cluster #1 Of 1), Eukaryotic	Eukaryotes	1300	0.26	Binding ≤ 10μM
E2AK4-1-E	Eukaryotic Translation Initiation Factor 2-alpha Kinase 4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	470	0.28	Binding ≤ 10μM
EGFR-1-E	Epidermal Growth Factor Receptor ErbB1 (cluster #1 Of 4), Eukaryotic	Eukaryotes	9000	0.22	Binding ≤ 10μM
EPHA6-1-E	Ephrin Type-A Receptor 6 (cluster #1 Of 1), Eukaryotic	Eukaryotes	2000	0.25	Binding ≤ 10μM
FAK1-1-E	Focal Adhesion Kinase 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1200	0.26	Binding ≤ 10μM
FAK2-1-E	Protein-tyrosine Kinase 2-beta (cluster #1 Of 1), Eukaryotic	Eukaryotes	600	0.27	Binding ≤ 10μM
FER-1-E	Tyrosine-protein Kinase FER (cluster #1 Of 1), Eukaryotic	Eukaryotes	34	0.33	Binding ≤ 10μM
FGFR1-1-E	Fibroblast Growth Factor Receptor 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1900	0.25	Binding ≤ 10μM
FGFR2-1-E	Fibroblast Growth Factor Receptor 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	790	0.27	Binding ≤ 10μM
FGFR3-1-E	Fibroblast Growth Factor Receptor 3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	560	0.27	Binding ≤ 10μM
FGR-1-E	Tyrosine-protein Kinase FGR (cluster #1 Of 2), Eukaryotic	Eukaryotes	390	0.28	Binding ≤ 10μM
FLT3-1-E	Tyrosine-protein Kinase Receptor FLT3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	6	0.36	Binding ≤ 10μM
FYN-1-E	Tyrosine-protein Kinase FYN (cluster #1 Of 5), Eukaryotic	Eukaryotes	2600	0.24	Binding ≤ 10μM
GAK-1-E	Serine/threonine-protein Kinase GAK (cluster #1 Of 2), Eukaryotic	Eukaryotes	44	0.32	Binding ≤ 10μM
HCK-1-E	Tyrosine-protein Kinase HCK (cluster #1 Of 1), Eukaryotic	Eukaryotes	2200	0.25	Binding ≤ 10μM
IKKE-1-E	Inhibitor Of Nuclear Factor Kappa B Kinase Epsilon Subunit (cluster #1 Of 1), Eukaryotic	Eukaryotes	480	0.28	Binding ≤ 10μM
INSR-1-E	Insulin Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	1200	0.26	Binding ≤ 10μM
INSRR-1-E	Insulin Receptor-related Protein (cluster #1 Of 1), Eukaryotic	Eukaryotes	2000	0.25	Binding ≤ 10μM
IRAK3-1-E	Interleukin-1 Receptor-associated Kinase 3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1900	0.25	Binding ≤ 10μM
ITK-1-E	Tyrosine-protein Kinase ITK/TSK (cluster #1 Of 1), Eukaryotic	Eukaryotes	190	0.29	Binding ≤ 10μM
JAK1-1-E	Tyrosine-protein Kinase JAK1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	97	0.31	Binding ≤ 10μM
JAK2-1-E	Tyrosine-protein Kinase JAK2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1600	0.25	Binding ≤ 10μM
JAK3-1-E	Tyrosine-protein Kinase JAK3 (cluster #1 Of 2), Eukaryotic	Eukaryotes	580	0.27	Binding ≤ 10μM
KC1AL-1-E	Casein Kinase I Isoform Alpha-like (cluster #1 Of 1), Eukaryotic	Eukaryotes	1500	0.25	Binding ≤ 10μM
KC1D-1-E	Casein Kinase I Delta (cluster #1 Of 1), Eukaryotic	Eukaryotes	260	0.29	Binding ≤ 10μM
KC1E-1-E	Casein Kinase I Epsilon (cluster #1 Of 2), Eukaryotic	Eukaryotes	340	0.28	Binding ≤ 10μM
KC1G1-1-E	Casein Kinase I Gamma 1 (cluster #1 Of 2), Eukaryotic	Eukaryotes	1000	0.26	Binding ≤ 10μM
KC1G2-1-E	Casein Kinase I Gamma 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	790	0.27	Binding ≤ 10μM
KC1G3-1-E	Casein Kinase I Isoform Gamma-3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	570	0.27	Binding ≤ 10μM
KCC1A-1-E	CaM Kinase I Alpha (cluster #1 Of 2), Eukaryotic	Eukaryotes	3300	0.24	Binding ≤ 10μM
KCC1D-1-E	CaM Kinase I Delta (cluster #1 Of 2), Eukaryotic	Eukaryotes	970	0.26	Binding ≤ 10μM
KCC1G-1-E	CaM Kinase I Gamma (cluster #1 Of 2), Eukaryotic	Eukaryotes	940	0.26	Binding ≤ 10μM
KCC2A-1-E	CaM Kinase II Alpha (cluster #1 Of 1), Eukaryotic	Eukaryotes	350	0.28	Binding ≤ 10μM
KCC2B-1-E	CaM Kinase II Beta (cluster #1 Of 1), Eukaryotic	Eukaryotes	2300	0.25	Binding ≤ 10μM
KCC2D-1-E	CaM Kinase II Delta (cluster #1 Of 1), Eukaryotic	Eukaryotes	760	0.27	Binding ≤ 10μM
KCC2G-1-E	CaM Kinase II Gamma (cluster #1 Of 1), Eukaryotic	Eukaryotes	1100	0.26	Binding ≤ 10μM
KCC4-1-E	CaM Kinase IV (cluster #1 Of 1), Eukaryotic	Eukaryotes	2700	0.24	Binding ≤ 10μM
KIT-1-E	Stem Cell Growth Factor Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	1	0.39	Binding ≤ 10μM
KIT-1-E	Stem Cell Growth Factor Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	340	0.28	Binding ≤ 10μM
KKCC1-1-E	CaM-kinase Kinase Alpha (cluster #1 Of 1), Eukaryotic	Eukaryotes	850	0.27	Binding ≤ 10μM
KKCC2-1-E	CaM-kinase Kinase Beta (cluster #1 Of 2), Eukaryotic	Eukaryotes	2500	0.25	Binding ≤ 10μM
KPCD1-1-E	Protein Kinase C Mu (cluster #1 Of 3), Eukaryotic	Eukaryotes	2400	0.25	Binding ≤ 10μM
KPCD2-1-E	Serine/threonine-protein Kinase D2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	3700	0.24	Binding ≤ 10μM
KPCD3-1-E	Protein Kinase C Nu (cluster #1 Of 3), Eukaryotic	Eukaryotes	2700	0.24	Binding ≤ 10μM
KPCT-1-E	Protein Kinase C Theta (cluster #1 Of 3), Eukaryotic	Eukaryotes	7200	0.22	Binding ≤ 10μM
KS6A1-1-E	Ribosomal Protein S6 Kinase Alpha 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	5800	0.23	Binding ≤ 10μM
KS6A2-1-E	Ribosomal Protein S6 Kinase Alpha 2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	9600	0.22	Binding ≤ 10μM
KS6A3-1-E	Ribosomal Protein S6 Kinase Alpha 3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	2100	0.25	Binding ≤ 10μM
KS6A4-1-E	Ribosomal Protein S6 Kinase Alpha 4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	2000	0.25	Binding ≤ 10μM
KS6A5-1-E	Ribosomal Protein S6 Kinase Alpha 5 (cluster #1 Of 3), Eukaryotic	Eukaryotes	1500	0.25	Binding ≤ 10μM
KS6A6-1-E	Ribosomal Protein S6 Kinase Alpha 6 (cluster #1 Of 1), Eukaryotic	Eukaryotes	3100	0.24	Binding ≤ 10μM
LATS1-1-E	Serine/threonine-protein Kinase LATS1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	850	0.27	Binding ≤ 10μM
LATS2-1-E	Serine/threonine-protein Kinase LATS2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	430	0.28	Binding ≤ 10μM
LCK-1-E	Tyrosine-protein Kinase LCK (cluster #1 Of 4), Eukaryotic	Eukaryotes	2300	0.25	Binding ≤ 10μM
LTK-1-E	Leukocyte Tyrosine Kinase Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	4200	0.24	Binding ≤ 10μM
LYN-1-E	Tyrosine-protein Kinase Lyn (cluster #1 Of 1), Eukaryotic	Eukaryotes	810	0.27	Binding ≤ 10μM
M3K11-1-E	Mitogen-activated Protein Kinase Kinase Kinase 11 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1700	0.25	Binding ≤ 10μM
M3K9-1-E	Mitogen-activated Protein Kinase Kinase Kinase 9 (cluster #1 Of 1), Eukaryotic	Eukaryotes	2600	0.24	Binding ≤ 10μM
M4K1-1-E	Mitogen-activated Protein Kinase Kinase Kinase Kinase 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	15	0.34	Binding ≤ 10μM
M4K3-1-E	Mitogen-activated Protein Kinase Kinase Kinase Kinase 3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	210	0.29	Binding ≤ 10μM
M4K4-1-E	Mitogen-activated Protein Kinase Kinase Kinase Kinase 4 (cluster #1 Of 2), Eukaryotic	Eukaryotes	260	0.29	Binding ≤ 10μM
M4K5-1-E	Mitogen-activated Protein Kinase Kinase Kinase Kinase 5 (cluster #1 Of 1), Eukaryotic	Eukaryotes	300	0.29	Binding ≤ 10μM
MARK1-1-E	Serine/threonine-protein Kinase MARK1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1500	0.25	Binding ≤ 10μM
MARK2-1-E	MAP/microtubule Affinity-regulating Kinase 2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	440	0.28	Binding ≤ 10μM
MARK3-1-E	Serine/threonine-protein Kinase C-TAK1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1100	0.26	Binding ≤ 10μM
MARK4-1-E	MAP/microtubule Affinity-regulating Kinase 4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	2000	0.25	Binding ≤ 10μM
MELK-1-E	Maternal Embryonic Leucine Zipper Kinase (cluster #1 Of 1), Eukaryotic	Eukaryotes	340	0.28	Binding ≤ 10μM
MERTK-1-E	Proto-oncogene Tyrosine-protein Kinase MER (cluster #1 Of 1), Eukaryotic	Eukaryotes	66	0.31	Binding ≤ 10μM
MKNK2-1-E	MAP Kinase Signal-integrating Kinase 2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	5500	0.23	Binding ≤ 10μM
MP2K1-1-E	Dual Specificity Mitogen-activated Protein Kinase Kinase 1 (cluster #1 Of 4), Eukaryotic	Eukaryotes	77	0.31	Binding ≤ 10μM
MP2K2-1-E	Dual Specificity Mitogen-activated Protein Kinase Kinase 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	120	0.30	Binding ≤ 10μM
MP2K4-1-E	Dual Specificity Mitogen-activated Protein Kinase Kinase 4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1400	0.26	Binding ≤ 10μM
MP2K6-1-E	Dual Specificity Mitogen-activated Protein Kinase Kinase 6 (cluster #1 Of 1), Eukaryotic	Eukaryotes	5500	0.23	Binding ≤ 10μM
MST4-1-E	Serine/threonine-protein Kinase MST4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	330	0.28	Binding ≤ 10μM
MUSK-1-E	Muscle, Skeletal Receptor Tyrosine Protein Kinase (cluster #1 Of 1), Eukaryotic	Eukaryotes	100	0.31	Binding ≤ 10μM
MYLK-1-E	Myosin Light Chain Kinase, Smooth Muscle (cluster #1 Of 1), Eukaryotic	Eukaryotes	360	0.28	Binding ≤ 10μM
MYLK2-1-E	Myosin Light Chain Kinase 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	190	0.29	Binding ≤ 10μM
MYLK4-1-E	Myosin Light Chain Kinase Family Member 4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	32	0.33	Binding ≤ 10μM
NEK2-1-E	Serine/threonine-protein Kinase NEK2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1100	0.26	Binding ≤ 10μM
NEK7-1-E	Serine/threonine-protein Kinase NEK7 (cluster #1 Of 1), Eukaryotic	Eukaryotes	3200	0.24	Binding ≤ 10μM
NTRK1-1-E	Nerve Growth Factor Receptor Trk-A (cluster #1 Of 1), Eukaryotic	Eukaryotes	480	0.28	Binding ≤ 10μM
NTRK2-1-E	Neurotrophic Tyrosine Kinase Receptor Type 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	990	0.26	Binding ≤ 10μM
NTRK3-1-E	NT-3 Growth Factor Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	220	0.29	Binding ≤ 10μM
NUAK1-1-E	NUAK Family SNF1-like Kinase 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	460	0.28	Binding ≤ 10μM
NUAK2-1-E	NUAK Family SNF1-like Kinase 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	400	0.28	Binding ≤ 10μM
PAK3-1-E	Serine/threonine-protein Kinase PAK 3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	190	0.29	Binding ≤ 10μM
PDPK1-1-E	3-phosphoinositide Dependent Protein Kinase-1 (cluster #1 Of 2), Eukaryotic	Eukaryotes	2600	0.24	Binding ≤ 10μM
PGFRA-1-E	Platelet-derived Growth Factor Receptor Alpha (cluster #1 Of 2), Eukaryotic	Eukaryotes	1	0.39	Binding ≤ 10μM
PGFRB-1-E	Platelet-derived Growth Factor Receptor Beta (cluster #1 Of 1), Eukaryotic	Eukaryotes	0	0.00	Binding ≤ 10μM
PHKG1-1-E	Phosphorylase Kinase Gamma Subunit 1 (cluster #1 Of 2), Eukaryotic	Eukaryotes	83	0.31	Binding ≤ 10μM
PHKG2-1-E	Phosphorylase Kinase Gamma Subunit 2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	100	0.31	Binding ≤ 10μM
PI42B-1-E	Phosphatidylinositol-5-phosphate 4-kinase Type-2 Beta (cluster #1 Of 1), Eukaryotic	Eukaryotes	260	0.29	Binding ≤ 10μM
PI51A-1-E	Phosphatidylinositol-4-phosphate 5-kinase Type-1 Alpha (cluster #1 Of 1), Eukaryotic	Eukaryotes	130	0.30	Binding ≤ 10μM
PIM3-1-E	Serine/threonine-protein Kinase PIM3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	2400	0.25	Binding ≤ 10μM
PKN1-1-E	Protein Kinase N1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1900	0.25	Binding ≤ 10μM
PKN2-1-E	Protein Kinase N2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	3800	0.24	Binding ≤ 10μM
PLK4-1-E	Serine/threonine-protein Kinase PLK4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	180	0.30	Binding ≤ 10μM
RET-1-E	Tyrosine-protein Kinase Receptor RET (cluster #1 Of 1), Eukaryotic	Eukaryotes	37	0.33	Binding ≤ 10μM
RIOK1-1-E	Serine/threonine-protein Kinase RIO1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	590	0.27	Binding ≤ 10μM
RIOK3-1-E	Serine/threonine-protein Kinase RIO3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	9700	0.22	Binding ≤ 10μM
RIPK1-1-E	Receptor-interacting Serine/threonine-protein Kinase 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1200	0.26	Binding ≤ 10μM
SIK1-1-E	Serine/threonine-protein Kinase SIK1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	2700	0.24	Binding ≤ 10μM
SIK2-1-E	Serine/threonine-protein Kinase SIK2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	750	0.27	Binding ≤ 10μM
SLK-1-E	Serine/threonine-protein Kinase 2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	460	0.28	Binding ≤ 10μM
SRC-1-E	Tyrosine-protein Kinase SRC (cluster #1 Of 3), Eukaryotic	Eukaryotes	4900	0.23	Binding ≤ 10μM
SRMS-1-E	Tyrosine-protein Kinase Srms (cluster #1 Of 1), Eukaryotic	Eukaryotes	62	0.32	Binding ≤ 10μM
SRPK1-1-E	Serine/threonine-protein Kinase SRPK1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	4000	0.24	Binding ≤ 10μM
SRPK2-1-E	Serine/threonine-protein Kinase SRPK2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	200	0.29	Binding ≤ 10μM
ST17A-1-E	Serine/threonine-protein Kinase 17A (cluster #1 Of 2), Eukaryotic	Eukaryotes	24	0.33	Binding ≤ 10μM
ST17B-1-E	Serine/threonine-protein Kinase 17B (cluster #1 Of 1), Eukaryotic	Eukaryotes	320	0.28	Binding ≤ 10μM
ST38L-1-E	Serine/threonine-protein Kinase 38-like (cluster #1 Of 2), Eukaryotic	Eukaryotes	2000	0.25	Binding ≤ 10μM
STK10-1-E	Serine/threonine-protein Kinase 10 (cluster #1 Of 1), Eukaryotic	Eukaryotes	230	0.29	Binding ≤ 10μM
STK11-1-E	Serine/threonine-protein Kinase 11 (cluster #1 Of 1), Eukaryotic	Eukaryotes	360	0.28	Binding ≤ 10μM
STK16-1-E	Serine/threonine-protein Kinase 16 (cluster #1 Of 1), Eukaryotic	Eukaryotes	730	0.27	Binding ≤ 10μM
STK24-1-E	Serine/threonine-protein Kinase 24 (cluster #1 Of 1), Eukaryotic	Eukaryotes	100	0.31	Binding ≤ 10μM
STK25-1-E	Serine/threonine-protein Kinase 25 (cluster #1 Of 1), Eukaryotic	Eukaryotes	360	0.28	Binding ≤ 10μM
STK3-1-E	Serine/threonine-protein Kinase MST2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	65	0.31	Binding ≤ 10μM
STK33-1-E	Serine/threonine-protein Kinase 33 (cluster #1 Of 1), Eukaryotic	Eukaryotes	130	0.30	Binding ≤ 10μM
STK4-1-E	Serine/threonine-protein Kinase MST1 (cluster #1 Of 2), Eukaryotic	Eukaryotes	130	0.30	Binding ≤ 10μM
TLK1-1-E	Serine/threonine-protein Kinase Tousled-like 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	630	0.27	Binding ≤ 10μM
TLK2-1-E	Serine/threonine-protein Kinase Tousled-like 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	270	0.29	Binding ≤ 10μM
TNIK-1-E	TRAF2- And NCK-interacting Kinase (cluster #1 Of 2), Eukaryotic	Eukaryotes	90	0.31	Binding ≤ 10μM
TNK1-1-E	Non-receptor Tyrosine-protein Kinase TNK1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1500	0.25	Binding ≤ 10μM
TTK-1-E	Dual Specificity Protein Kinase TTK (cluster #1 Of 2), Eukaryotic	Eukaryotes	180	0.30	Binding ≤ 10μM
TYK2-1-E	Tyrosine-protein Kinase TYK2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	5100	0.23	Binding ≤ 10μM
TYRO3-1-E	Tyrosine-protein Kinase Receptor TYRO3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	2400	0.25	Binding ≤ 10μM
UFO-1-E	Tyrosine-protein Kinase Receptor UFO (cluster #1 Of 1), Eukaryotic	Eukaryotes	84	0.31	Binding ≤ 10μM
VGFR1-1-E	Vascular Endothelial Growth Factor Receptor 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	5	0.36	Binding ≤ 10μM
VGFR2-1-E	Vascular Endothelial Growth Factor Receptor 2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	2	0.38	Binding ≤ 10μM
VGFR3-1-E	Vascular Endothelial Growth Factor Receptor 3 (cluster #1 Of 2), Eukaryotic	Eukaryotes	50	0.32	Binding ≤ 10μM
WEE1-1-E	Serine/threonine-protein Kinase WEE1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	3000	0.24	Binding ≤ 10μM
YES-1-E	Tyrosine-protein Kinase YES (cluster #1 Of 1), Eukaryotic	Eukaryotes	260	0.29	Binding ≤ 10μM

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	0.40	1.96	-15.81	4	8	0	110	442.491	6	↓ MOL2 SDF SMILES Flexibase

23247639

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: AST-48 AST-48

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Vendors

Activity (Go SEA)

Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
AAPK1-1-E	AMP-activated Protein Kinase, Alpha-1 Subunit (cluster #1 Of 1), Eukaryotic	Eukaryotes	1400	0.22	Binding ≤ 10μM
ABL1-1-E	Tyrosine-protein Kinase ABL (cluster #1 Of 1), Eukaryotic	Eukaryotes	8	0.30	Binding ≤ 10μM
ABL2-1-E	Tyrosine-protein Kinase ABL2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	3	0.31	Binding ≤ 10μM
ALK-1-E	ALK Tyrosine Kinase Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	1400	0.22	Binding ≤ 10μM
ANKK1-1-E	Ankyrin Repeat And Protein Kinase Domain-containing Protein 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	630	0.23	Binding ≤ 10μM
AURKC-1-E	Serine/threonine-protein Kinase Aurora-C (cluster #1 Of 2), Eukaryotic	Eukaryotes	740	0.23	Binding ≤ 10μM
BLK-1-E	Tyrosine-protein Kinase BLK (cluster #1 Of 1), Eukaryotic	Eukaryotes	30	0.28	Binding ≤ 10μM
BRAF-1-E	Serine/threonine-protein Kinase B-raf (cluster #1 Of 1), Eukaryotic	Eukaryotes	1700	0.21	Binding ≤ 10μM
CD11A-1-E	PITSLRE Serine/threonine-protein Kinase CDC2L2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1100	0.22	Binding ≤ 10μM
CD11B-1-E	PITSLRE Serine/threonine-protein Kinase CDC2L1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1400	0.22	Binding ≤ 10μM
CDK14-1-E	Serine/threonine-protein Kinase PFTAIRE-1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	17	0.29	Binding ≤ 10μM
CDK16-1-E	Serine/threonine-protein Kinase PCTAIRE-1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	420	0.23	Binding ≤ 10μM
CDK17-1-E	Serine/threonine-protein Kinase PCTAIRE-2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	15	0.29	Binding ≤ 10μM
CDK18-1-E	Serine/threonine-protein Kinase PCTAIRE-3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	54	0.27	Binding ≤ 10μM
CDK19-1-E	Cell Division Cycle 2-like Protein Kinase 6 (cluster #1 Of 1), Eukaryotic	Eukaryotes	2	0.32	Binding ≤ 10μM
CDK2-1-E	Cyclin-dependent Kinase 2 (cluster #1 Of 5), Eukaryotic	Eukaryotes	760	0.23	Binding ≤ 10μM
CDK3-1-E	Cyclin-dependent Kinase 3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	82	0.26	Binding ≤ 10μM
CDK5-1-E	Cyclin-dependent Kinase 5 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1000	0.22	Binding ≤ 10μM
CDK7-1-E	Cyclin-dependent Kinase 7 (cluster #1 Of 1), Eukaryotic	Eukaryotes	5	0.31	Binding ≤ 10μM
CDK8-1-E	Cell Division Protein Kinase 8 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1	0.33	Binding ≤ 10μM
CDK9-1-E	Cyclin-dependent Kinase 9 (cluster #1 Of 2), Eukaryotic	Eukaryotes	190	0.25	Binding ≤ 10μM
CLK1-1-E	Dual Specificty Protein Kinase CLK1 (cluster #1 Of 2), Eukaryotic	Eukaryotes	110	0.26	Binding ≤ 10μM
CLK2-1-E	Dual Specificity Protein Kinase CLK2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	1800	0.21	Binding ≤ 10μM
CLK4-1-E	Dual Specificity Protein Kinase CLK4 (cluster #1 Of 2), Eukaryotic	Eukaryotes	290	0.24	Binding ≤ 10μM
CSF1R-1-E	Macrophage Colony-stimulating Factor 1 Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	6	0.30	Binding ≤ 10μM
CSK-1-E	Tyrosine-protein Kinase CSK (cluster #1 Of 1), Eukaryotic	Eukaryotes	2300	0.21	Binding ≤ 10μM
CTRO-1-E	Citron Rho-interacting Kinase (cluster #1 Of 1), Eukaryotic	Eukaryotes	52	0.27	Binding ≤ 10μM
DAPK3-1-E	Death-associated Protein Kinase 3 (cluster #1 Of 2), Eukaryotic	Eukaryotes	3200	0.20	Binding ≤ 10μM
DDR1-1-E	Epithelial Discoidin Domain-containing Receptor 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1	0.33	Binding ≤ 10μM
DDR2-1-E	Discoidin Domain-containing Receptor 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	11	0.29	Binding ≤ 10μM
E2AK2-1-E	Interferon-induced, Double-stranded RNA-activated Protein Kinase (cluster #1 Of 1), Eukaryotic	Eukaryotes	1100	0.22	Binding ≤ 10μM
EGFR-3-E	Epidermal Growth Factor Receptor ErbB1 (cluster #3 Of 4), Eukaryotic	Eukaryotes	970	0.22	Binding ≤ 10μM
EPHA2-1-E	Ephrin Type-A Receptor 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	160	0.25	Binding ≤ 10μM
EPHA3-1-E	Ephrin Type-A Receptor 3 (cluster #1 Of 2), Eukaryotic	Eukaryotes	80	0.26	Binding ≤ 10μM
EPHA4-1-E	Ephrin Type-A Receptor 4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	400	0.24	Binding ≤ 10μM
EPHA5-1-E	Ephrin Type-A Receptor 5 (cluster #1 Of 1), Eukaryotic	Eukaryotes	140	0.25	Binding ≤ 10μM
EPHA6-1-E	Ephrin Type-A Receptor 6 (cluster #1 Of 1), Eukaryotic	Eukaryotes	380	0.24	Binding ≤ 10μM
EPHA7-1-E	Ephrin Type-A Receptor 7 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1100	0.22	Binding ≤ 10μM
EPHA8-1-E	Ephrin Type-A Receptor 8 (cluster #1 Of 1), Eukaryotic	Eukaryotes	18	0.29	Binding ≤ 10μM
EPHB1-1-E	Ephrin Type-B Receptor 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	180	0.25	Binding ≤ 10μM
EPHB2-1-E	Ephrin Type-B Receptor 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	130	0.25	Binding ≤ 10μM
FAK2-1-E	Protein-tyrosine Kinase 2-beta (cluster #1 Of 1), Eukaryotic	Eukaryotes	520	0.23	Binding ≤ 10μM
FER-1-E	Tyrosine-protein Kinase FER (cluster #1 Of 1), Eukaryotic	Eukaryotes	590	0.23	Binding ≤ 10μM
FES-1-E	Tyrosine-protein Kinase FES (cluster #1 Of 1), Eukaryotic	Eukaryotes	360	0.24	Binding ≤ 10μM
FGFR1-1-E	Fibroblast Growth Factor Receptor 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	620	0.23	Binding ≤ 10μM
FGFR2-1-E	Fibroblast Growth Factor Receptor 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1900	0.21	Binding ≤ 10μM
FGFR4-1-E	Fibroblast Growth Factor Receptor 4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1400	0.22	Binding ≤ 10μM
FGR-1-E	Tyrosine-protein Kinase FGR (cluster #1 Of 2), Eukaryotic	Eukaryotes	190	0.25	Binding ≤ 10μM
FLT3-1-E	Tyrosine-protein Kinase Receptor FLT3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	5	0.31	Binding ≤ 10μM
FRK-1-E	Tyrosine-protein Kinase FRK (cluster #1 Of 1), Eukaryotic	Eukaryotes	26	0.28	Binding ≤ 10μM
FYN-1-E	Tyrosine-protein Kinase FYN (cluster #1 Of 5), Eukaryotic	Eukaryotes	50	0.27	Binding ≤ 10μM
GAK-1-E	Serine/threonine-protein Kinase GAK (cluster #1 Of 2), Eukaryotic	Eukaryotes	1300	0.22	Binding ≤ 10μM
HCK-1-E	Tyrosine-protein Kinase HCK (cluster #1 Of 1), Eukaryotic	Eukaryotes	880	0.22	Binding ≤ 10μM
INSRR-1-E	Insulin Receptor-related Protein (cluster #1 Of 1), Eukaryotic	Eukaryotes	1400	0.22	Binding ≤ 10μM
ITK-1-E	Tyrosine-protein Kinase ITK/TSK (cluster #1 Of 1), Eukaryotic	Eukaryotes	990	0.22	Binding ≤ 10μM
JAK2-1-E	Tyrosine-protein Kinase JAK2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	910	0.22	Binding ≤ 10μM
JAK3-1-E	Tyrosine-protein Kinase JAK3 (cluster #1 Of 2), Eukaryotic	Eukaryotes	260	0.24	Binding ≤ 10μM
KAPCA-1-E	CAMP-dependent Protein Kinase Alpha-catalytic Subunit (cluster #1 Of 4), Eukaryotic	Eukaryotes	3700	0.20	Binding ≤ 10μM
KAPCB-1-E	CAMP-dependent Protein Kinase Beta-1 Catalytic Subunit (cluster #1 Of 3), Eukaryotic	Eukaryotes	260	0.24	Binding ≤ 10μM
KC1D-1-E	Casein Kinase I Delta (cluster #1 Of 1), Eukaryotic	Eukaryotes	2500	0.21	Binding ≤ 10μM
KC1E-1-E	Casein Kinase I Epsilon (cluster #1 Of 2), Eukaryotic	Eukaryotes	4000	0.20	Binding ≤ 10μM
KC1G2-1-E	Casein Kinase I Gamma 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	950	0.22	Binding ≤ 10μM
KC1G3-1-E	Casein Kinase I Isoform Gamma-3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	97	0.26	Binding ≤ 10μM
KCC1A-1-E	CaM Kinase I Alpha (cluster #1 Of 2), Eukaryotic	Eukaryotes	3000	0.20	Binding ≤ 10μM
KCC4-1-E	CaM Kinase IV (cluster #1 Of 1), Eukaryotic	Eukaryotes	3700	0.20	Binding ≤ 10μM
KIT-1-E	Stem Cell Growth Factor Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	5	0.31	Binding ≤ 10μM
KKCC1-1-E	CaM-kinase Kinase Alpha (cluster #1 Of 1), Eukaryotic	Eukaryotes	220	0.25	Binding ≤ 10μM
KKCC2-1-E	CaM-kinase Kinase Beta (cluster #1 Of 2), Eukaryotic	Eukaryotes	220	0.25	Binding ≤ 10μM
KPCD1-1-E	Protein Kinase C Mu (cluster #1 Of 3), Eukaryotic	Eukaryotes	1200	0.22	Binding ≤ 10μM
KPCD2-1-E	Serine/threonine-protein Kinase D2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	950	0.22	Binding ≤ 10μM
KPCD3-1-E	Protein Kinase C Nu (cluster #1 Of 3), Eukaryotic	Eukaryotes	1500	0.21	Binding ≤ 10μM
KPCT-1-E	Protein Kinase C Theta (cluster #1 Of 3), Eukaryotic	Eukaryotes	2200	0.21	Binding ≤ 10μM
KS6A2-1-E	Ribosomal Protein S6 Kinase Alpha 2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	1100	0.22	Binding ≤ 10μM
KS6A4-1-E	Ribosomal Protein S6 Kinase Alpha 4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1900	0.21	Binding ≤ 10μM
KS6A5-1-E	Ribosomal Protein S6 Kinase Alpha 5 (cluster #1 Of 3), Eukaryotic	Eukaryotes	730	0.23	Binding ≤ 10μM
KS6A6-1-E	Ribosomal Protein S6 Kinase Alpha 6 (cluster #1 Of 1), Eukaryotic	Eukaryotes	4600	0.20	Binding ≤ 10μM
KSYK-1-E	Tyrosine-protein Kinase SYK (cluster #1 Of 2), Eukaryotic	Eukaryotes	600	0.23	Binding ≤ 10μM
LATS1-1-E	Serine/threonine-protein Kinase LATS1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	470	0.23	Binding ≤ 10μM
LATS2-1-E	Serine/threonine-protein Kinase LATS2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	3000	0.20	Binding ≤ 10μM
LCK-1-E	Tyrosine-protein Kinase LCK (cluster #1 Of 4), Eukaryotic	Eukaryotes	11	0.29	Binding ≤ 10μM
LTK-1-E	Leukocyte Tyrosine Kinase Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	160	0.25	Binding ≤ 10μM
LYN-1-E	Tyrosine-protein Kinase Lyn (cluster #1 Of 1), Eukaryotic	Eukaryotes	14	0.29	Binding ≤ 10μM
M4K1-1-E	Mitogen-activated Protein Kinase Kinase Kinase Kinase 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	210	0.25	Binding ≤ 10μM
M4K3-1-E	Mitogen-activated Protein Kinase Kinase Kinase Kinase 3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	190	0.25	Binding ≤ 10μM
M4K4-1-E	Mitogen-activated Protein Kinase Kinase Kinase Kinase 4 (cluster #1 Of 2), Eukaryotic	Eukaryotes	15	0.29	Binding ≤ 10μM
M4K5-1-E	Mitogen-activated Protein Kinase Kinase Kinase Kinase 5 (cluster #1 Of 1), Eukaryotic	Eukaryotes	350	0.24	Binding ≤ 10μM
MELK-1-E	Maternal Embryonic Leucine Zipper Kinase (cluster #1 Of 1), Eukaryotic	Eukaryotes	830	0.22	Binding ≤ 10μM
MERTK-1-E	Proto-oncogene Tyrosine-protein Kinase MER (cluster #1 Of 1), Eukaryotic	Eukaryotes	370	0.24	Binding ≤ 10μM
MET-1-E	Hepatocyte Growth Factor Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	4400	0.20	Binding ≤ 10μM
MK08-1-E	Mitogen-activated Protein Kinase 8 (cluster #1 Of 5), Eukaryotic	Eukaryotes	460	0.23	Binding ≤ 10μM
MK09-1-E	C-Jun N-terminal Kinase 2 (cluster #1 Of 3), Eukaryotic	Eukaryotes	56	0.27	Binding ≤ 10μM
MK10-1-E	C-Jun N-terminal Kinase 3 (cluster #1 Of 2), Eukaryotic	Eukaryotes	760	0.23	Binding ≤ 10μM
MK11-1-E	MAP Kinase P38 Beta (cluster #1 Of 1), Eukaryotic	Eukaryotes	430	0.23	Binding ≤ 10μM
MK12-1-E	MAP Kinase P38 Gamma (cluster #1 Of 2), Eukaryotic	Eukaryotes	29	0.28	Binding ≤ 10μM
MK14-1-E	MAP Kinase P38 Alpha (cluster #1 Of 3), Eukaryotic	Eukaryotes	73	0.26	Binding ≤ 10μM
MK15-1-E	Mitogen-activated Protein Kinase 15 (cluster #1 Of 1), Eukaryotic	Eukaryotes	94	0.26	Binding ≤ 10μM
MKNK1-1-E	MAP Kinase-interacting Serine/threonine-protein Kinase MNK1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	26	0.28	Binding ≤ 10μM
MKNK2-1-E	MAP Kinase Signal-integrating Kinase 2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	3	0.31	Binding ≤ 10μM
MLTK-1-E	Mixed Lineage Kinase 7 (cluster #1 Of 1), Eukaryotic	Eukaryotes	2	0.32	Binding ≤ 10μM
MUSK-1-E	Muscle, Skeletal Receptor Tyrosine Protein Kinase (cluster #1 Of 1), Eukaryotic	Eukaryotes	3	0.31	Binding ≤ 10μM
MYLK2-1-E	Myosin Light Chain Kinase 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	330	0.24	Binding ≤ 10μM
MYO3A-1-E	Myosin IIIA (cluster #1 Of 1), Eukaryotic	Eukaryotes	41	0.27	Binding ≤ 10μM
MYO3B-1-E	Myosin-IIIB (cluster #1 Of 1), Eukaryotic	Eukaryotes	84	0.26	Binding ≤ 10μM
NEK5-1-E	Serine/threonine-protein Kinase Nek5 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1100	0.22	Binding ≤ 10μM
NLK-1-E	Serine/threonine Protein Kinase NLK (cluster #1 Of 1), Eukaryotic	Eukaryotes	160	0.25	Binding ≤ 10μM
NTRK1-1-E	Nerve Growth Factor Receptor Trk-A (cluster #1 Of 1), Eukaryotic	Eukaryotes	320	0.24	Binding ≤ 10μM
NTRK2-1-E	Neurotrophic Tyrosine Kinase Receptor Type 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	190	0.25	Binding ≤ 10μM
NTRK3-1-E	NT-3 Growth Factor Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	34	0.28	Binding ≤ 10μM
PGFRA-1-E	Platelet-derived Growth Factor Receptor Alpha (cluster #1 Of 2), Eukaryotic	Eukaryotes	27	0.28	Binding ≤ 10μM
PGFRB-1-E	Platelet-derived Growth Factor Receptor Beta (cluster #1 Of 1), Eukaryotic	Eukaryotes	8	0.30	Binding ≤ 10μM
RAF1-1-E	Serine/threonine-protein Kinase RAF (cluster #1 Of 1), Eukaryotic	Eukaryotes	930	0.22	Binding ≤ 10μM
RET-1-E	Tyrosine-protein Kinase Receptor RET (cluster #1 Of 1), Eukaryotic	Eukaryotes	5	0.31	Binding ≤ 10μM
RIPK1-1-E	Receptor-interacting Serine/threonine-protein Kinase 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	210	0.25	Binding ≤ 10μM
RIPK2-1-E	Serine/threonine-protein Kinase RIPK2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1100	0.22	Binding ≤ 10μM
ROS1-1-E	Proto-oncogene Tyrosine-protein Kinase ROS (cluster #1 Of 1), Eukaryotic	Eukaryotes	1700	0.21	Binding ≤ 10μM
SIK1-1-E	Serine/threonine-protein Kinase SIK1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1700	0.21	Binding ≤ 10μM
SLK-1-E	Serine/threonine-protein Kinase 2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	23	0.28	Binding ≤ 10μM
SRC-1-E	Tyrosine-protein Kinase SRC (cluster #1 Of 3), Eukaryotic	Eukaryotes	340	0.24	Binding ≤ 10μM
SRMS-1-E	Tyrosine-protein Kinase Srms (cluster #1 Of 1), Eukaryotic	Eukaryotes	72	0.26	Binding ≤ 10μM
STK10-1-E	Serine/threonine-protein Kinase 10 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1	0.33	Binding ≤ 10μM
STK25-1-E	Serine/threonine-protein Kinase 25 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1200	0.22	Binding ≤ 10μM
STK3-1-E	Serine/threonine-protein Kinase MST2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	860	0.22	Binding ≤ 10μM
STK33-1-E	Serine/threonine-protein Kinase 33 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1200	0.22	Binding ≤ 10μM
STK36-1-E	Serine/threonine-protein Kinase 36 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1300	0.22	Binding ≤ 10μM
TESK1-1-E	Dual Specificity Testis-specific Protein Kinase 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	2400	0.21	Binding ≤ 10μM
TGFR2-1-E	TGF-beta Receptor Type II (cluster #1 Of 1), Eukaryotic	Eukaryotes	260	0.24	Binding ≤ 10μM
TIE1-1-E	Tyrosine-protein Kinase Receptor Tie-1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	0	0.00	Binding ≤ 10μM
TIE2-1-E	Tyrosine-protein Kinase TIE-2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	19	0.28	Binding ≤ 10μM
TNI3K-1-E	Serine/threonine-protein Kinase TNNI3K (cluster #1 Of 1), Eukaryotic	Eukaryotes	170	0.25	Binding ≤ 10μM
TNIK-1-E	TRAF2- And NCK-interacting Kinase (cluster #1 Of 2), Eukaryotic	Eukaryotes	69	0.26	Binding ≤ 10μM
TNK1-1-E	Non-receptor Tyrosine-protein Kinase TNK1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	60	0.27	Binding ≤ 10μM
TTK-1-E	Dual Specificity Protein Kinase TTK (cluster #1 Of 2), Eukaryotic	Eukaryotes	230	0.24	Binding ≤ 10μM
TYK2-1-E	Tyrosine-protein Kinase TYK2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	2100	0.21	Binding ≤ 10μM
UFO-1-E	Tyrosine-protein Kinase Receptor UFO (cluster #1 Of 1), Eukaryotic	Eukaryotes	570	0.23	Binding ≤ 10μM
VGFR1-1-E	Vascular Endothelial Growth Factor Receptor 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	86	0.26	Binding ≤ 10μM
VGFR2-1-E	Vascular Endothelial Growth Factor Receptor 2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	200	0.25	Binding ≤ 10μM
VGFR3-1-E	Vascular Endothelial Growth Factor Receptor 3 (cluster #1 Of 2), Eukaryotic	Eukaryotes	120	0.25	Binding ≤ 10μM
YES-1-E	Tyrosine-protein Kinase YES (cluster #1 Of 1), Eukaryotic	Eukaryotes	260	0.24	Binding ≤ 10μM

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	4.19	9.79	-45.6	4	9	1	96	530.575	9	↓ MOL2 SDF SMILES Flexibase
Mid Mid (pH 6-8)	4.19	8.71	-41.75	4	9	1	96	530.575	9	↓ MOL2 SDF SMILES Flexibase
Mid Mid (pH 6-8)	4.19	7.48	-16.83	3	9	0	95	529.567	9	↓ MOL2 SDF SMILES Flexibase

35902489

Analogs

35902488

Draw Identity 99% 90% 80% 70%

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Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
ABL1-1-E	Tyrosine-protein Kinase ABL (cluster #1 Of 1), Eukaryotic	Eukaryotes	1159	0.28	Binding ≤ 10μM
ALK-1-E	ALK Tyrosine Kinase Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	600	0.29	Binding ≤ 10μM
INSR-1-E	Insulin Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	650	0.29	Binding ≤ 10μM
LCK-1-E	Tyrosine-protein Kinase LCK (cluster #1 Of 4), Eukaryotic	Eukaryotes	2741	0.26	Binding ≤ 10μM
MET-1-E	Hepatocyte Growth Factor Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	8	0.38	Binding ≤ 10μM
MET-1-E	Hepatocyte Growth Factor Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	19	0.36	Binding ≤ 10μM
NTRK1-1-E	Nerve Growth Factor Receptor Trk-A (cluster #1 Of 1), Eukaryotic	Eukaryotes	580	0.29	Binding ≤ 10μM
NTRK2-1-E	Neurotrophic Tyrosine Kinase Receptor Type 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	399	0.30	Binding ≤ 10μM
RON-1-E	Macrophage-stimulating Protein Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	80	0.33	Binding ≤ 10μM
TIE2-1-E	Tyrosine-protein Kinase TIE-2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	448	0.30	Binding ≤ 10μM
UFO-1-E	Tyrosine-protein Kinase Receptor UFO (cluster #1 Of 1), Eukaryotic	Eukaryotes	294	0.30	Binding ≤ 10μM

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	4.01	9.09	-96.36	5	6	2	84	452.361	5	↓ MOL2 SDF SMILES Flexibase
Mid Mid (pH 6-8)	4.01	8.61	-52.37	4	6	1	83	451.353	5	↓ MOL2 SDF SMILES Flexibase

3875028

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: SU 6656 SU 6656

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Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
ALK-1-E	ALK Tyrosine Kinase Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	1	0.48	Binding ≤ 10μM
FLT3-1-E	Tyrosine-protein Kinase Receptor FLT3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	8700	0.27	Binding ≤ 10μM
FYN-1-E	Tyrosine-protein Kinase FYN (cluster #1 Of 5), Eukaryotic	Eukaryotes	170	0.36	Binding ≤ 10μM
LYN-1-E	Tyrosine-protein Kinase Lyn (cluster #1 Of 1), Eukaryotic	Eukaryotes	130	0.37	Binding ≤ 10μM
RET-1-E	Tyrosine-protein Kinase Receptor RET (cluster #1 Of 1), Eukaryotic	Eukaryotes	770	0.33	Binding ≤ 10μM
SRC-1-E	Tyrosine-protein Kinase SRC (cluster #1 Of 3), Eukaryotic	Eukaryotes	280	0.35	Binding ≤ 10μM
YES-1-E	Tyrosine-protein Kinase YES (cluster #1 Of 1), Eukaryotic	Eukaryotes	20	0.41	Binding ≤ 10μM
Z50425-3-O	Plasmodium Falciparum (cluster #3 Of 22), Other	Other	5012	0.29	Functional ≤ 10μM

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	2.75	5.22	-14.78	2	6	0	86	371.462	3	↓ MOL2 SDF SMILES Flexibase

602803

Analogs

11524396
34393732

Draw Identity 99% 90% 80% 70%

Popular Name: Pelitinib Pelitinib

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Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
AAK1-1-E	Adaptor-associated Kinase (cluster #1 Of 2), Eukaryotic	Eukaryotes	3500	0.23	Binding ≤ 10μM
ABL1-1-E	Tyrosine-protein Kinase ABL (cluster #1 Of 1), Eukaryotic	Eukaryotes	860	0.26	Binding ≤ 10μM
ABL2-1-E	Tyrosine-protein Kinase ABL2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	370	0.27	Binding ≤ 10μM
ACK1-1-E	Tyrosine Kinase Non-receptor Protein 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	890	0.26	Binding ≤ 10μM
ADCK4-1-E	Uncharacterized AarF Domain-containing Protein Kinase 4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	6100	0.22	Binding ≤ 10μM
ALK-1-E	ALK Tyrosine Kinase Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	7100	0.22	Binding ≤ 10μM
BLK-1-E	Tyrosine-protein Kinase BLK (cluster #1 Of 1), Eukaryotic	Eukaryotes	78	0.30	Binding ≤ 10μM
BMP2K-1-E	BMP-2-inducible Protein Kinase (cluster #1 Of 2), Eukaryotic	Eukaryotes	540	0.27	Binding ≤ 10μM
BMX-1-E	Tyrosine-protein Kinase BMX (cluster #1 Of 1), Eukaryotic	Eukaryotes	7400	0.22	Binding ≤ 10μM
BTK-1-E	Tyrosine-protein Kinase BTK (cluster #1 Of 1), Eukaryotic	Eukaryotes	4900	0.23	Binding ≤ 10μM
CDK16-1-E	Serine/threonine-protein Kinase PCTAIRE-1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	10000	0.21	Binding ≤ 10μM
CHK1-1-E	Serine/threonine-protein Kinase Chk1 (cluster #1 Of 2), Eukaryotic	Eukaryotes	1900	0.24	Binding ≤ 10μM
CLK1-2-E	Dual Specificty Protein Kinase CLK1 (cluster #2 Of 2), Eukaryotic	Eukaryotes	3300	0.23	Binding ≤ 10μM
CLK2-1-E	Dual Specificity Protein Kinase CLK2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	700	0.26	Binding ≤ 10μM
CLK3-1-E	Dual Specificity Protein Kinase CLK3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	5600	0.22	Binding ≤ 10μM
CLK4-1-E	Dual Specificity Protein Kinase CLK4 (cluster #1 Of 2), Eukaryotic	Eukaryotes	3900	0.23	Binding ≤ 10μM
CSF1R-1-E	Macrophage Colony-stimulating Factor 1 Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	4300	0.23	Binding ≤ 10μM
CSK-1-E	Tyrosine-protein Kinase CSK (cluster #1 Of 1), Eukaryotic	Eukaryotes	3400	0.23	Binding ≤ 10μM
CTRO-1-E	Citron Rho-interacting Kinase (cluster #1 Of 1), Eukaryotic	Eukaryotes	310	0.28	Binding ≤ 10μM
DAPK3-1-E	Death-associated Protein Kinase 3 (cluster #1 Of 2), Eukaryotic	Eukaryotes	4100	0.23	Binding ≤ 10μM
DCLK3-1-E	Serine/threonine-protein Kinase DCLK3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	4900	0.23	Binding ≤ 10μM
DMPK-1-E	Myotonin-protein Kinase (cluster #1 Of 1), Eukaryotic	Eukaryotes	59	0.31	Binding ≤ 10μM
DYR1B-1-E	Dual Specificity Tyrosine-phosphorylation-regulated Kinase 1B (cluster #1 Of 1), Eukaryotic	Eukaryotes	4000	0.23	Binding ≤ 10μM
E2AK2-1-E	Interferon-induced, Double-stranded RNA-activated Protein Kinase (cluster #1 Of 1), Eukaryotic	Eukaryotes	1900	0.24	Binding ≤ 10μM
E2AK4-1-E	Eukaryotic Translation Initiation Factor 2-alpha Kinase 4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	290	0.28	Binding ≤ 10μM
EGFR-1-E	Epidermal Growth Factor Receptor ErbB1 (cluster #1 Of 4), Eukaryotic	Eukaryotes	98	0.30	Binding ≤ 10μM
EPHA3-1-E	Ephrin Type-A Receptor 3 (cluster #1 Of 2), Eukaryotic	Eukaryotes	4100	0.23	Binding ≤ 10μM
EPHA5-1-E	Ephrin Type-A Receptor 5 (cluster #1 Of 1), Eukaryotic	Eukaryotes	710	0.26	Binding ≤ 10μM
EPHA6-1-E	Ephrin Type-A Receptor 6 (cluster #1 Of 1), Eukaryotic	Eukaryotes	4100	0.23	Binding ≤ 10μM
EPHA8-1-E	Ephrin Type-A Receptor 8 (cluster #1 Of 1), Eukaryotic	Eukaryotes	400	0.27	Binding ≤ 10μM
EPHB1-1-E	Ephrin Type-B Receptor 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	4200	0.23	Binding ≤ 10μM
EPHB4-1-E	Ephrin Type-B Receptor 4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	2800	0.24	Binding ≤ 10μM
ERBB2-2-E	Receptor Protein-tyrosine Kinase ErbB-2 (cluster #2 Of 3), Eukaryotic	Eukaryotes	77	0.30	Binding ≤ 10μM
FAK1-1-E	Focal Adhesion Kinase 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	4400	0.23	Binding ≤ 10μM
FER-1-E	Tyrosine-protein Kinase FER (cluster #1 Of 1), Eukaryotic	Eukaryotes	8800	0.21	Binding ≤ 10μM
FES-1-E	Tyrosine-protein Kinase FES (cluster #1 Of 1), Eukaryotic	Eukaryotes	5700	0.22	Binding ≤ 10μM
FGR-1-E	Tyrosine-protein Kinase FGR (cluster #1 Of 2), Eukaryotic	Eukaryotes	950	0.26	Binding ≤ 10μM
FLT3-1-E	Tyrosine-protein Kinase Receptor FLT3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	3300	0.23	Binding ≤ 10μM
FRK-1-E	Tyrosine-protein Kinase FRK (cluster #1 Of 1), Eukaryotic	Eukaryotes	680	0.26	Binding ≤ 10μM
FYN-1-E	Tyrosine-protein Kinase FYN (cluster #1 Of 5), Eukaryotic	Eukaryotes	2400	0.24	Binding ≤ 10μM
GAK-1-E	Serine/threonine-protein Kinase GAK (cluster #1 Of 2), Eukaryotic	Eukaryotes	6	0.35	Binding ≤ 10μM
HCK-1-E	Tyrosine-protein Kinase HCK (cluster #1 Of 1), Eukaryotic	Eukaryotes	2300	0.24	Binding ≤ 10μM
ITK-1-E	Tyrosine-protein Kinase ITK/TSK (cluster #1 Of 1), Eukaryotic	Eukaryotes	2500	0.24	Binding ≤ 10μM
JAK2-1-E	Tyrosine-protein Kinase JAK2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	2000	0.24	Binding ≤ 10μM
JAK3-1-E	Tyrosine-protein Kinase JAK3 (cluster #1 Of 2), Eukaryotic	Eukaryotes	25	0.32	Binding ≤ 10μM
KC1AL-1-E	Casein Kinase I Isoform Alpha-like (cluster #1 Of 1), Eukaryotic	Eukaryotes	1000	0.25	Binding ≤ 10μM
KC1D-1-E	Casein Kinase I Delta (cluster #1 Of 1), Eukaryotic	Eukaryotes	1100	0.25	Binding ≤ 10μM
KC1E-1-E	Casein Kinase I Epsilon (cluster #1 Of 2), Eukaryotic	Eukaryotes	97	0.30	Binding ≤ 10μM
KCC1D-1-E	CaM Kinase I Delta (cluster #1 Of 2), Eukaryotic	Eukaryotes	5900	0.22	Binding ≤ 10μM
KKCC1-1-E	CaM-kinase Kinase Alpha (cluster #1 Of 1), Eukaryotic	Eukaryotes	5100	0.22	Binding ≤ 10μM
KKCC2-1-E	CaM-kinase Kinase Beta (cluster #1 Of 2), Eukaryotic	Eukaryotes	2500	0.24	Binding ≤ 10μM
KPCD-1-E	Protein Kinase C Delta (cluster #1 Of 4), Eukaryotic	Eukaryotes	4600	0.23	Binding ≤ 10μM
KS6A2-1-E	Ribosomal Protein S6 Kinase Alpha 2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	8700	0.21	Binding ≤ 10μM
KSYK-1-E	Tyrosine-protein Kinase SYK (cluster #1 Of 2), Eukaryotic	Eukaryotes	7200	0.22	Binding ≤ 10μM
LCK-1-E	Tyrosine-protein Kinase LCK (cluster #1 Of 4), Eukaryotic	Eukaryotes	99	0.30	Binding ≤ 10μM
LYN-1-E	Tyrosine-protein Kinase Lyn (cluster #1 Of 1), Eukaryotic	Eukaryotes	960	0.26	Binding ≤ 10μM
M3K4-1-E	Mitogen-activated Protein Kinase Kinase Kinase 4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	280	0.28	Binding ≤ 10μM
M4K1-1-E	Mitogen-activated Protein Kinase Kinase Kinase Kinase 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	270	0.28	Binding ≤ 10μM
M4K3-1-E	Mitogen-activated Protein Kinase Kinase Kinase Kinase 3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	170	0.29	Binding ≤ 10μM
M4K4-1-E	Mitogen-activated Protein Kinase Kinase Kinase Kinase 4 (cluster #1 Of 2), Eukaryotic	Eukaryotes	330	0.27	Binding ≤ 10μM
M4K5-1-E	Mitogen-activated Protein Kinase Kinase Kinase Kinase 5 (cluster #1 Of 1), Eukaryotic	Eukaryotes	4	0.36	Binding ≤ 10μM
MARK1-1-E	Serine/threonine-protein Kinase MARK1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	4000	0.23	Binding ≤ 10μM
MERTK-1-E	Proto-oncogene Tyrosine-protein Kinase MER (cluster #1 Of 1), Eukaryotic	Eukaryotes	1300	0.25	Binding ≤ 10μM
MET-1-E	Hepatocyte Growth Factor Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	6200	0.22	Binding ≤ 10μM
MLTK-1-E	Mixed Lineage Kinase 7 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1200	0.25	Binding ≤ 10μM
MP2K1-3-E	Dual Specificity Mitogen-activated Protein Kinase Kinase 1 (cluster #3 Of 4), Eukaryotic	Eukaryotes	360	0.27	Binding ≤ 10μM
MP2K2-1-E	Dual Specificity Mitogen-activated Protein Kinase Kinase 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	810	0.26	Binding ≤ 10μM
MYLK2-1-E	Myosin Light Chain Kinase 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	3900	0.23	Binding ≤ 10μM
NEK1-1-E	Serine/threonine-protein Kinase Nek1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	3900	0.23	Binding ≤ 10μM
NEK2-1-E	Serine/threonine-protein Kinase NEK2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	680	0.26	Binding ≤ 10μM
NUAK2-1-E	NUAK Family SNF1-like Kinase 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	2700	0.24	Binding ≤ 10μM
PAK1-1-E	Serine/threonine-protein Kinase PAK 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	3400	0.23	Binding ≤ 10μM
PHKG1-1-E	Phosphorylase Kinase Gamma Subunit 1 (cluster #1 Of 2), Eukaryotic	Eukaryotes	3500	0.23	Binding ≤ 10μM
PHKG2-1-E	Phosphorylase Kinase Gamma Subunit 2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	2500	0.24	Binding ≤ 10μM
PI42B-1-E	Phosphatidylinositol-5-phosphate 4-kinase Type-2 Beta (cluster #1 Of 1), Eukaryotic	Eukaryotes	2600	0.24	Binding ≤ 10μM
PMYT1-1-E	Tyrosine- And Threonine-specific Cdc2-inhibitory Kinase (cluster #1 Of 1), Eukaryotic	Eukaryotes	930	0.26	Binding ≤ 10μM
SIK2-1-E	Serine/threonine-protein Kinase SIK2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	4500	0.23	Binding ≤ 10μM
SLK-1-E	Serine/threonine-protein Kinase 2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	360	0.27	Binding ≤ 10μM
SRC-1-E	Tyrosine-protein Kinase SRC (cluster #1 Of 3), Eukaryotic	Eukaryotes	280	0.28	Binding ≤ 10μM
ST17A-1-E	Serine/threonine-protein Kinase 17A (cluster #1 Of 2), Eukaryotic	Eukaryotes	57	0.31	Binding ≤ 10μM
ST17B-1-E	Serine/threonine-protein Kinase 17B (cluster #1 Of 1), Eukaryotic	Eukaryotes	4200	0.23	Binding ≤ 10μM
ST32B-1-E	Serine/threonine-protein Kinase 32B (cluster #1 Of 1), Eukaryotic	Eukaryotes	6000	0.22	Binding ≤ 10μM
ST38L-1-E	Serine/threonine-protein Kinase 38-like (cluster #1 Of 2), Eukaryotic	Eukaryotes	3100	0.23	Binding ≤ 10μM
STK10-1-E	Serine/threonine-protein Kinase 10 (cluster #1 Of 1), Eukaryotic	Eukaryotes	330	0.27	Binding ≤ 10μM
STK24-1-E	Serine/threonine-protein Kinase 24 (cluster #1 Of 1), Eukaryotic	Eukaryotes	2100	0.24	Binding ≤ 10μM
STK25-1-E	Serine/threonine-protein Kinase 25 (cluster #1 Of 1), Eukaryotic	Eukaryotes	3400	0.23	Binding ≤ 10μM
STK3-1-E	Serine/threonine-protein Kinase MST2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	1100	0.25	Binding ≤ 10μM
STK33-1-E	Serine/threonine-protein Kinase 33 (cluster #1 Of 1), Eukaryotic	Eukaryotes	4500	0.23	Binding ≤ 10μM
STK36-1-E	Serine/threonine-protein Kinase 36 (cluster #1 Of 1), Eukaryotic	Eukaryotes	4000	0.23	Binding ≤ 10μM
STK4-1-E	Serine/threonine-protein Kinase MST1 (cluster #1 Of 2), Eukaryotic	Eukaryotes	3900	0.23	Binding ≤ 10μM
TBA1A-1-E	Tubulin Alpha-3 Chain (cluster #1 Of 3), Eukaryotic	Eukaryotes	21	0.33	Binding ≤ 10μM
TIE1-1-E	Tyrosine-protein Kinase Receptor Tie-1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	1000	0.25	Binding ≤ 10μM
TIE2-1-E	Tyrosine-protein Kinase TIE-2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	2900	0.23	Binding ≤ 10μM
TNI3K-1-E	Serine/threonine-protein Kinase TNNI3K (cluster #1 Of 1), Eukaryotic	Eukaryotes	7200	0.22	Binding ≤ 10μM
TNIK-1-E	TRAF2- And NCK-interacting Kinase (cluster #1 Of 2), Eukaryotic	Eukaryotes	45	0.31	Binding ≤ 10μM
TXK-1-E	Tyrosine-protein Kinase TXK (cluster #1 Of 1), Eukaryotic	Eukaryotes	5500	0.22	Binding ≤ 10μM
TYRO3-1-E	Tyrosine-protein Kinase Receptor TYRO3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	3700	0.23	Binding ≤ 10μM
UFO-1-E	Tyrosine-protein Kinase Receptor UFO (cluster #1 Of 1), Eukaryotic	Eukaryotes	920	0.26	Binding ≤ 10μM
ULK3-1-E	Serine/threonine-protein Kinase ULK3 (cluster #1 Of 2), Eukaryotic	Eukaryotes	3800	0.23	Binding ≤ 10μM
VGFR2-1-E	Vascular Endothelial Growth Factor Receptor 2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	3131	0.23	Binding ≤ 10μM
WEE1-1-E	Serine/threonine-protein Kinase WEE1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	770	0.26	Binding ≤ 10μM
YES-1-E	Tyrosine-protein Kinase YES (cluster #1 Of 1), Eukaryotic	Eukaryotes	840	0.26	Binding ≤ 10μM
EGFR-1-E	Epidermal Growth Factor Receptor ErbB1 (cluster #1 Of 2), Eukaryotic	Eukaryotes	80	0.30	Functional ≤ 10μM
ERBB2-2-E	Receptor Protein-tyrosine Kinase ErbB-2 (cluster #2 Of 3), Eukaryotic	Eukaryotes	1230	0.25	Functional ≤ 10μM
Z80475-3-O	SK-BR-3 (Breast Adenocarcinoma) (cluster #3 Of 3), Other	Other	680	0.26	Functional ≤ 10μM
Z80852-3-O	A-431 (Epidermoid Carcinoma Cells) (cluster #3 Of 3), Other	Other	80	0.30	Functional ≤ 10μM
Z81331-1-O	SW-620 (Colon Adenocarcinoma Cells) (cluster #1 Of 6), Other	Other	680	0.26	Functional ≤ 10μM

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	4.74	1.81	-47.09	3	7	1	91	468.94	8	↓ MOL2 SDF SMILES Flexibase

Parameters Provided:

annotation.name = ALK_HUMAN
anotation.type = B10
page.format = summary
page.num = 1
filter.purchasability = purchasable

Structural Results Found: (before additional filtering)

SQL Query Was

SELECT DISTINCT(ci.sub_id_fk) AS sub_id FROM catalog_item AS ci INNER JOIN catalog AS c ON ci.cat_id_fk=c.cat_id INNER JOIN note AS n ON ci.sub_id_fk=n.sub_id_fk INNER JOIN annotation AS a ON n.anno_id_fk=a.anno_id  WHERE c.free = 1 AND a.short_desc LIKE 'ALK\\_HUMAN' AND c.purchasable IN (1,2,4,5)    LIMIT 50

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