| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| September 29th, 2005 | 37 | No |
Popular Name: DPC 423 DPC 423
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 4.45 | -1.53 | -64.17 | 4 | 7 | 1 | 108 | 533.527 | 7 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| FA10-1-E | Coagulation Factor X (cluster #1 Of 2), Eukaryotic | Eukaryotes | 150 | 0.26 | Binding ≤ 10μM |
| FA9-1-E | Coagulation Factor IX (cluster #1 Of 1), Eukaryotic | Eukaryotes | 2200 | 0.21 | Binding ≤ 10μM |
| KLK1-2-E | Kallikrein 1 (cluster #2 Of 2), Eukaryotic | Eukaryotes | 61 | 0.27 | Binding ≤ 10μM |
| KLKB1-1-E | Plasma Kallikrein (cluster #1 Of 3), Eukaryotic | Eukaryotes | 61 | 0.27 | Binding ≤ 10μM |
| PROC-1-E | Vitamin K-dependent Protein C (cluster #1 Of 1), Eukaryotic | Eukaryotes | 1800 | 0.22 | Binding ≤ 10μM |
| THRB-4-E | Prothrombin (cluster #4 Of 8), Eukaryotic | Eukaryotes | 6000 | 0.20 | Binding ≤ 10μM |
| TRY1-1-E | Trypsin I (cluster #1 Of 5), Eukaryotic | Eukaryotes | 60 | 0.27 | Binding ≤ 10μM |
| TRY2-1-E | Trypsin II (cluster #1 Of 3), Eukaryotic | Eukaryotes | 60 | 0.27 | Binding ≤ 10μM |
| Z50592-3-O | Oryctolagus Cuniculus (cluster #3 Of 8), Other | Other | 150 | 0.26 | Functional ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| FA10_HUMAN | P00742 | Coagulation Factor X, Human | 0.15 | 0.37 | Binding ≤ 1μM |
| KLK1_HUMAN | P06870 | Kallikrein 1, Human | 61 | 0.27 | Binding ≤ 1μM |
| KLKB1_HUMAN | P03952 | Plasma Kallikrein, Human | 61 | 0.27 | Binding ≤ 1μM |
| TRY1_HUMAN | P07477 | Trypsin I, Human | 60 | 0.27 | Binding ≤ 1μM |
| TRY2_HUMAN | P07478 | Trypsin II, Human | 60 | 0.27 | Binding ≤ 1μM |
| FA9_HUMAN | P00740 | Coagulation Factor IX, Human | 2200 | 0.21 | Binding ≤ 10μM |
| FA10_HUMAN | P00742 | Coagulation Factor X, Human | 0.15 | 0.37 | Binding ≤ 10μM |
| KLK1_HUMAN | P06870 | Kallikrein 1, Human | 61 | 0.27 | Binding ≤ 10μM |
| KLKB1_HUMAN | P03952 | Plasma Kallikrein, Human | 61 | 0.27 | Binding ≤ 10μM |
| THRB_HUMAN | P00734 | Thrombin, Human | 6000 | 0.20 | Binding ≤ 10μM |
| TRY1_HUMAN | P07477 | Trypsin I, Human | 60 | 0.27 | Binding ≤ 10μM |
| TRY2_HUMAN | P07478 | Trypsin II, Human | 60 | 0.27 | Binding ≤ 10μM |
| PROC_HUMAN | P04070 | Vitamin K-dependent Protein C, Human | 1800 | 0.22 | Binding ≤ 10μM |
| Z50592 | Z50592 | Oryctolagus Cuniculus | 137 | 0.26 | Functional ≤ 10μM |
| Description | Species |
|---|---|
| Activation of Matrix Metalloproteinases | |
| Alpha-defensins | |
| Cell surface interactions at the vascular wall | |
| Cobalamin (Cbl, vitamin B12) transport and metabolism | |
| Collagen degradation | |
| Common Pathway | |
| Extrinsic Pathway | |
| G alpha (q) signalling events | |
| Gamma-carboxylation of protein precursors | |
| Intrinsic Pathway | |
| Peptide ligand-binding receptors | |
| Platelet Aggregation (Plug Formation) | |
| Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l | |
| Removal of aminoterminal propeptides from gamma-carboxylated proteins | |
| Thrombin signalling through proteinase activated receptors (PARs) | |
| Transport of gamma-carboxylated protein precursors from the endoplasmic reticulu |
No pre-computed analogs available. Try a structural similarity search.