| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| November 11th, 2008 | 13 | Yes |
Popular Name: AMPA AMPA
Find On: PubMed — Wikipedia — Google
CAS Numbers: 118896-96-1 , 118896-96-1; 77521-29-0 , 171259-81-7 , 74341-63-2 , 77521-29-0 , 83643-88-3 , 83654-13-1 , 84799-50-8
(+/-)-Alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid hydrate
(+/-)-ALPHA-AMINO-3-HYDROXY-5-METHYLISOXAZOLE-4-PROPIONIC ACID HYDROBROMIDE
(+/-)-alpha-Amino-3-hydroxy-5-methylisoxazole-4-propionicAcidHydrobromide
(R)-2-Amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propanoic acid hydrobromide
(R,S)-¦Á-Amino-3-hydroxy-5-methyl-4-isoxazolepropionicAcidHydrobromide
(S)-alpha-Amino-3-hydroXy-5-methyl-4-isoXazolepropionicAcid
2-Amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propanoic acid hydrobromide
3-(3-Hydroxy-5-methylisoxazol-4-yl)-DL-alanine
77521-29-0; AMPA; C13672; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | -2.69 | -1.91 | -52.1 | 3 | 6 | -1 | 117 | 185.159 | 3 | ↓ |
| Lo Low (pH 4.5-6) | -2.69 | -2.52 | -37.61 | 4 | 6 | 0 | 114 | 186.167 | 3 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| GRIA1-1-E | Glutamate Receptor Ionotropic, AMPA 1 (cluster #1 Of 4), Eukaryotic | Eukaryotes | 364 | 0.69 | Binding ≤ 10μM |
| GRIA1-1-E | Glutamate Receptor Ionotropic, AMPA 1 (cluster #1 Of 4), Eukaryotic | Eukaryotes | 4800 | 0.57 | Binding ≤ 10μM |
| GRIA2-4-E | Glutamate Receptor Ionotropic, AMPA 2 (cluster #4 Of 4), Eukaryotic | Eukaryotes | 364 | 0.69 | Binding ≤ 10μM |
| GRIA2-4-E | Glutamate Receptor Ionotropic, AMPA 2 (cluster #4 Of 4), Eukaryotic | Eukaryotes | 4800 | 0.57 | Binding ≤ 10μM |
| GRIA3-4-E | Glutamate Receptor Ionotropic, AMPA 3 (cluster #4 Of 4), Eukaryotic | Eukaryotes | 40 | 0.80 | Binding ≤ 10μM |
| GRIA3-4-E | Glutamate Receptor Ionotropic, AMPA 3 (cluster #4 Of 4), Eukaryotic | Eukaryotes | 4800 | 0.57 | Binding ≤ 10μM |
| GRIA4-4-E | Glutamate Receptor Ionotropic, AMPA 4 (cluster #4 Of 5), Eukaryotic | Eukaryotes | 40 | 0.80 | Binding ≤ 10μM |
| GRIA4-4-E | Glutamate Receptor Ionotropic, AMPA 4 (cluster #4 Of 5), Eukaryotic | Eukaryotes | 4800 | 0.57 | Binding ≤ 10μM |
| GRIK1-1-E | Glutamate Receptor Ionotropic Kainate 1 (cluster #1 Of 3), Eukaryotic | Eukaryotes | 740 | 0.66 | Binding ≤ 10μM |
| GRIK2-3-E | Glutamate Receptor Ionotropic Kainate 2 (cluster #3 Of 3), Eukaryotic | Eukaryotes | 12 | 0.85 | Binding ≤ 10μM |
| GRIK3-3-E | Glutamate Receptor Ionotropic Kainate 3 (cluster #3 Of 3), Eukaryotic | Eukaryotes | 12 | 0.85 | Binding ≤ 10μM |
| GRIK4-1-E | Glutamate Receptor Ionotropic Kainate 4 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 12 | 0.85 | Binding ≤ 10μM |
| GRIK5-1-E | Glutamate Receptor Ionotropic Kainate 5 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 12 | 0.85 | Binding ≤ 10μM |
| GRIA1-1-E | Glutamate Receptor Ionotropic, AMPA 1 (cluster #1 Of 3), Eukaryotic | Eukaryotes | 3310 | 0.59 | Functional ≤ 10μM |
| GRIA2-1-E | Glutamate Receptor Ionotropic, AMPA 2 (cluster #1 Of 4), Eukaryotic | Eukaryotes | 3310 | 0.59 | Functional ≤ 10μM |
| GRIA3-1-E | Glutamate Receptor Ionotropic, AMPA 3 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 3500 | 0.59 | Functional ≤ 10μM |
| GRIA4-1-E | Glutamate Receptor Ionotropic, AMPA 4 (cluster #1 Of 3), Eukaryotic | Eukaryotes | 3500 | 0.59 | Functional ≤ 10μM |
| Z50597-1-O | Rattus Norvegicus (cluster #1 Of 12), Other | Other | 800 | 0.66 | Functional ≤ 10μM |
| Z50597-1-O | Rattus Norvegicus (cluster #1 Of 12), Other | Other | 4800 | 0.57 | Functional ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| GRIK1_HUMAN | P39086 | Glutamate Receptor Ionotropic Kainate 1, Human | 740 | 0.66 | Binding ≤ 1μM |
| GRIK1_RAT | P22756 | Glutamate Receptor Ionotropic Kainate 1, Rat | 1.2 | 0.96 | Binding ≤ 1μM |
| GRIK2_RAT | P42260 | Glutamate Receptor Ionotropic Kainate 2, Rat | 12 | 0.85 | Binding ≤ 1μM |
| GRIK3_RAT | P42264 | Glutamate Receptor Ionotropic Kainate 3, Rat | 12 | 0.85 | Binding ≤ 1μM |
| GRIK4_RAT | Q01812 | Glutamate Receptor Ionotropic Kainate 4, Rat | 12 | 0.85 | Binding ≤ 1μM |
| GRIK5_RAT | Q63273 | Glutamate Receptor Ionotropic Kainate 5, Rat | 12 | 0.85 | Binding ≤ 1μM |
| GRIA1_RAT | P19490 | Glutamate Receptor Ionotropic, AMPA 1, Rat | 0.1 | 1.08 | Binding ≤ 1μM |
| GRIA1_HUMAN | P42261 | Glutamate Receptor Ionotropic, AMPA 1, Human | 19 | 0.83 | Binding ≤ 1μM |
| GRIA1_MOUSE | P23818 | Glutamate Receptor Ionotropic, AMPA 1, Mouse | 40 | 0.80 | Binding ≤ 1μM |
| GRIA2_HUMAN | P42262 | Glutamate Receptor Ionotropic, AMPA 2, Human | 17 | 0.84 | Binding ≤ 1μM |
| GRIA2_MOUSE | P23819 | Glutamate Receptor Ionotropic, AMPA 2, Mouse | 40 | 0.80 | Binding ≤ 1μM |
| GRIA2_RAT | P19491 | Glutamate Receptor Ionotropic, AMPA 2, Rat | 0.1 | 1.08 | Binding ≤ 1μM |
| GRIA3_HUMAN | P42263 | Glutamate Receptor Ionotropic, AMPA 3, Human | 19 | 0.83 | Binding ≤ 1μM |
| GRIA3_MOUSE | Q9Z2W9 | Glutamate Receptor Ionotropic, AMPA 3, Mouse | 40 | 0.80 | Binding ≤ 1μM |
| GRIA3_RAT | P19492 | Glutamate Receptor Ionotropic, AMPA 3, Rat | 0.1 | 1.08 | Binding ≤ 1μM |
| GRIA4_MOUSE | Q9Z2W8 | Glutamate Receptor Ionotropic, AMPA 4, Mouse | 40 | 0.80 | Binding ≤ 1μM |
| GRIA4_RAT | P19493 | Glutamate Receptor Ionotropic, AMPA 4, Rat | 0.1 | 1.08 | Binding ≤ 1μM |
| GRIA4_HUMAN | P48058 | Glutamate Receptor Ionotropic, AMPA 4, Human | 19 | 0.83 | Binding ≤ 1μM |
| GRIK1_HUMAN | P39086 | Glutamate Receptor Ionotropic Kainate 1, Human | 740 | 0.66 | Binding ≤ 10μM |
| GRIK1_RAT | P22756 | Glutamate Receptor Ionotropic Kainate 1, Rat | 1.2 | 0.96 | Binding ≤ 10μM |
| GRIK2_RAT | P42260 | Glutamate Receptor Ionotropic Kainate 2, Rat | 12 | 0.85 | Binding ≤ 10μM |
| GRIK3_RAT | P42264 | Glutamate Receptor Ionotropic Kainate 3, Rat | 12 | 0.85 | Binding ≤ 10μM |
| GRIK4_RAT | Q01812 | Glutamate Receptor Ionotropic Kainate 4, Rat | 12 | 0.85 | Binding ≤ 10μM |
| GRIK5_RAT | Q63273 | Glutamate Receptor Ionotropic Kainate 5, Rat | 12 | 0.85 | Binding ≤ 10μM |
| GRIA1_MOUSE | P23818 | Glutamate Receptor Ionotropic, AMPA 1, Mouse | 40 | 0.80 | Binding ≤ 10μM |
| GRIA1_RAT | P19490 | Glutamate Receptor Ionotropic, AMPA 1, Rat | 0.1 | 1.08 | Binding ≤ 10μM |
| GRIA1_HUMAN | P42261 | Glutamate Receptor Ionotropic, AMPA 1, Human | 19 | 0.83 | Binding ≤ 10μM |
| GRIA2_MOUSE | P23819 | Glutamate Receptor Ionotropic, AMPA 2, Mouse | 40 | 0.80 | Binding ≤ 10μM |
| GRIA2_RAT | P19491 | Glutamate Receptor Ionotropic, AMPA 2, Rat | 0.1 | 1.08 | Binding ≤ 10μM |
| GRIA2_HUMAN | P42262 | Glutamate Receptor Ionotropic, AMPA 2, Human | 17 | 0.84 | Binding ≤ 10μM |
| GRIA3_MOUSE | Q9Z2W9 | Glutamate Receptor Ionotropic, AMPA 3, Mouse | 40 | 0.80 | Binding ≤ 10μM |
| GRIA3_RAT | P19492 | Glutamate Receptor Ionotropic, AMPA 3, Rat | 0.1 | 1.08 | Binding ≤ 10μM |
| GRIA3_HUMAN | P42263 | Glutamate Receptor Ionotropic, AMPA 3, Human | 19 | 0.83 | Binding ≤ 10μM |
| GRIA4_MOUSE | Q9Z2W8 | Glutamate Receptor Ionotropic, AMPA 4, Mouse | 40 | 0.80 | Binding ≤ 10μM |
| GRIA4_RAT | P19493 | Glutamate Receptor Ionotropic, AMPA 4, Rat | 0.1 | 1.08 | Binding ≤ 10μM |
| GRIA4_HUMAN | P48058 | Glutamate Receptor Ionotropic, AMPA 4, Human | 19 | 0.83 | Binding ≤ 10μM |
| GRIA1_MOUSE | P23818 | Glutamate Receptor Ionotropic, AMPA 1, Mouse | 3500 | 0.59 | Functional ≤ 10μM |
| GRIA1_RAT | P19490 | Glutamate Receptor Ionotropic, AMPA 1, Rat | 8700 | 0.54 | Functional ≤ 10μM |
| GRIA1_HUMAN | P42261 | Glutamate Receptor Ionotropic, AMPA 1, Human | 3310 | 0.59 | Functional ≤ 10μM |
| GRIA2_RAT | P19491 | Glutamate Receptor Ionotropic, AMPA 2, Rat | 3500 | 0.59 | Functional ≤ 10μM |
| GRIA2_HUMAN | P42262 | Glutamate Receptor Ionotropic, AMPA 2, Human | 3310 | 0.59 | Functional ≤ 10μM |
| GRIA3_RAT | P19492 | Glutamate Receptor Ionotropic, AMPA 3, Rat | 1400 | 0.63 | Functional ≤ 10μM |
| GRIA4_RAT | P19493 | Glutamate Receptor Ionotropic, AMPA 4, Rat | 3500 | 0.59 | Functional ≤ 10μM |
| Z50597 | Z50597 | Rattus Norvegicus | 3500 | 0.59 | Functional ≤ 10μM |
| Description | Species |
|---|---|
| Activation of AMPA receptors | |
| Activation of Ca-permeable Kainate Receptor | |
| Activation of Na-permeable Kainate Receptors | |
| Trafficking of AMPA receptors | |
| Trafficking of GluR2-containing AMPA receptors | |
| Unblocking of NMDA receptor, glutamate binding and activation |
