| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| October 24th, 2005 | 36 | No |
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 5.84 | -3.64 | -16.37 | 2 | 6 | 0 | 79 | 638.832 | 3 | ↓ |
| Lo Low (pH 4.5-6) | 5.84 | -3.78 | -49.07 | 3 | 6 | 1 | 80 | 639.84 | 3 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| FNTA-1-E | Protein Farnesyltransferase/geranylgeranyltransferase Type I Alpha Subunit (cluster #1 Of 3), Eukaryotic | Eukaryotes | 2 | 0.34 | Binding ≤ 10μM |
| FNTB-1-E | Protein Farnesyltransferase Beta Subunit (cluster #1 Of 3), Eukaryotic | Eukaryotes | 2 | 0.34 | Binding ≤ 10μM |
| FNTA-1-E | Protein Farnesyltransferase/geranylgeranyltransferase Type I Alpha Subunit (cluster #1 Of 2), Eukaryotic | Eukaryotes | 100 | 0.27 | Functional ≤ 10μM |
| FNTB-1-E | Protein Farnesyltransferase Beta Subunit (cluster #1 Of 2), Eukaryotic | Eukaryotes | 100 | 0.27 | Functional ≤ 10μM |
| RASH-1-E | Transforming Protein P21/H-Ras-1 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 70 | 0.28 | Functional ≤ 10μM |
| Z80106-1-O | COS-1 (Kidney Cells) (cluster #1 Of 1), Other | Other | 75 | 0.28 | Functional ≤ 10μM |
| Z80224-1-O | MCF7 (Breast Carcinoma Cells) (cluster #1 Of 14), Other | Other | 50 | 0.28 | Functional ≤ 10μM |
| Z80928-3-O | HCT-116 (Colon Carcinoma Cells) (cluster #3 Of 9), Other | Other | 70 | 0.28 | Functional ≤ 10μM |
| Z80951-1-O | NIH3T3 (Fibroblasts) (cluster #1 Of 4), Other | Other | 160 | 0.26 | Functional ≤ 10μM |
| Z81285-1-O | NIH-H Cell Line (cluster #1 Of 1), Other | Other | 72 | 0.28 | Functional ≤ 10μM |
| Z81286-1-O | NIH-K Cell Line (cluster #1 Of 1), Other | Other | 500 | 0.25 | Functional ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| FNTB_HUMAN | P49356 | Protein Farnesyltransferase Beta Subunit, Human | 1.9 | 0.34 | Binding ≤ 1μM |
| FNTB_BOVIN | P49355 | Protein Farnesyltransferase Beta Subunit, Bovin | 7.8 | 0.32 | Binding ≤ 1μM |
| FNTA_HUMAN | P49354 | Protein Farnesyltransferase/geranylgeranyltransferase Type I Alpha Subunit, Human | 1.9 | 0.34 | Binding ≤ 1μM |
| FNTA_BOVIN | P29702 | Protein Farnesyltransferase/geranylgeranyltransferase Type I Alpha Subunit, Bovin | 7.8 | 0.32 | Binding ≤ 1μM |
| FNTA_RAT | Q04631 | Protein Farnesyltransferase/geranylgeranyltransferase Type I Alpha Subunit, Rat | 2 | 0.34 | Binding ≤ 1μM |
| FNTB_HUMAN | P49356 | Protein Farnesyltransferase Beta Subunit, Human | 1.9 | 0.34 | Binding ≤ 10μM |
| FNTB_BOVIN | P49355 | Protein Farnesyltransferase Beta Subunit, Bovin | 7.8 | 0.32 | Binding ≤ 10μM |
| FNTA_RAT | Q04631 | Protein Farnesyltransferase/geranylgeranyltransferase Type I Alpha Subunit, Rat | 2 | 0.34 | Binding ≤ 10μM |
| FNTA_HUMAN | P49354 | Protein Farnesyltransferase/geranylgeranyltransferase Type I Alpha Subunit, Human | 1.9 | 0.34 | Binding ≤ 10μM |
| FNTA_BOVIN | P29702 | Protein Farnesyltransferase/geranylgeranyltransferase Type I Alpha Subunit, Bovin | 7.8 | 0.32 | Binding ≤ 10μM |
| Z80106 | Z80106 | COS-1 (Kidney Cells) | 10 | 0.31 | Functional ≤ 10μM |
| Z80928 | Z80928 | HCT-116 (Colon Carcinoma Cells) | 70 | 0.28 | Functional ≤ 10μM |
| Z80224 | Z80224 | MCF7 (Breast Carcinoma Cells) | 50 | 0.28 | Functional ≤ 10μM |
| Z81285 | Z81285 | NIH-H Cell Line | 72 | 0.28 | Functional ≤ 10μM |
| Z81286 | Z81286 | NIH-K Cell Line | 500 | 0.25 | Functional ≤ 10μM |
| Z80951 | Z80951 | NIH3T3 (Fibroblasts) | 100 | 0.27 | Functional ≤ 10μM |
| FNTB_MOUSE | Q8K2I1 | Protein Farnesyltransferase Beta Subunit, Mouse | 100 | 0.27 | Functional ≤ 10μM |
| FNTB_HUMAN | P49356 | Protein Farnesyltransferase Beta Subunit, Human | 10 | 0.31 | Functional ≤ 10μM |
| FNTA_MOUSE | Q61239 | Protein Farnesyltransferase/geranylgeranyltransferase Type I Alpha Subunit, Mouse | 100 | 0.27 | Functional ≤ 10μM |
| FNTA_HUMAN | P49354 | Protein Farnesyltransferase/geranylgeranyltransferase Type I Alpha Subunit, Human | 10 | 0.31 | Functional ≤ 10μM |
| RASH_HUMAN | P01112 | Transforming Protein P21/H-Ras-1, Human | 70 | 0.28 | Functional ≤ 10μM |
| Description | Species |
|---|---|
| Activation of RAS in B cells | |
| Apoptotic cleavage of cellular proteins | |
| DAP12 signaling | |
| Downstream signal transduction | |
| EGFR Transactivation by Gastrin | |
| EPHB-mediated forward signaling | |
| FCERI mediated MAPK activation | |
| FRS2-mediated cascade | |
| GRB2 events in EGFR signaling | |
| GRB2 events in ERBB2 signaling | |
| Inactivation, recovery and regulation of the phototransduction cascade | |
| Interleukin receptor SHC signaling | |
| MEK activation | |
| NCAM signaling for neurite out-growth | |
| p38MAPK events | |
| RAF activation | |
| RAF phosphorylates MEK | |
| Ras activation uopn Ca2+ infux through NMDA receptor | |
| SHC-mediated cascade | |
| SHC-mediated signalling | |
| SHC1 events in EGFR signaling | |
| SHC1 events in ERBB2 signaling | |
| SHC1 events in ERBB4 signaling | |
| Signaling by constitutively active EGFR | |
| Signaling by FGFR mutants | |
| Signaling by SCF-KIT | |
| Signalling to RAS | |
| SOS-mediated signalling | |
| Tie2 Signaling | |
| VEGFR2 mediated cell proliferation |
