| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| August 19th, 2004 | 32 | Yes |
Popular Name: Sorafenib Sorafenib
Find On: PubMed — Wikipedia — Google
CAS Numbers: 284461-73-0 , 1130115-44-4 , 212141-54-3 , 284461-73-0 , 284461-73-0; 475207-59-1 , 475207-59-1 , 959-24-0 , [284461-73-0] , [475207-59-1] , [959-24-0]
284461-73-0; D08524; Sorafenib (USAN/INN)
4(4-{3-[4-Chloro-3-(trifluoromethyl)phenyl]ureido}phenoxy)-N(sup 2)-methylpyridine-2-carboxamide
4-(4-{3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido}phenoxy)-N(sup 2)-methylpyridine-2-carboxamide
4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide
4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-pyridine-2-carboxamide
4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide
4-{4-[3-(4-Chloro-3-trifluoromethyl-phenyl)-ureido]-phenoxy}-pyridine-2-carboxylic acid methylamide
475207-59-1; D06272; Nexavar (TN); Sorafenib tosilate (JAN); Sorafenib tosylate (USAN)
N-(4-chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-methylcar bamoyl)-4-pyridyloxy)phenyl)urea
N-(4-Chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-methylcarbamoyl)-4-pyridyloxy)phenyl)urea
N-[4-Chloro-3-(trifluoromethyl)phenyl]-N'-[4-[2-(N-methylcarbamoyl)-4-pyridyloxy]phenyl]urea
N-{4-[1-Hydroxy-2-(isopropylamino)ethyl]phenyl}methanesulfonamide hydrochloride (1:1)
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 4.76 | 6.55 | -16.07 | 3 | 7 | 0 | 92 | 464.831 | 6 | ↓ |
| Note Type | Comments | Provided By |
|---|---|---|
| ALOGPS_SOLUBILITY | 1.71e-03 g/l | DrugBank-approved |
| purity | 9.500000000000000e+001 | Enamine Building Blocks Enamine Building Blocks |
| Purity | >99% | Fluorochem |
| Indications | antineoplastic | KeyOrganics Bioactives |
| biological_use | Drug for the treatment of advanced renal cell carcinoma (primary kidney cancer) | ZereneX Building Blocks |
| biological_use | Drug for the treatment of advanced renal cell carcinoma (primary kidney cancer) | IBScreen Bioactives |
| Patent Database Links | EP1900742; EP1947114; EP1977765; EP1982718; EP1990342; US2005032798; US2005276812; US2007185069; US2007248604; US2007259031; US2008051463; WO2006027346; WO2006075012; WO2006079644; WO2006079645; WO2006084869; WO2006084904; WO2006097323; WO2006097474; WO20 | ChEBI |
| mechanism | Inhibitor of Raf kinase | IBScreen Bioactives ZereneX Building Blocks |
| mechanism | PDGF (platelet-derived growth factor) | IBScreen Bioactives |
| UniProt Database Links | PGFRA_HUMAN; PGFRA_MOUSE; PGFRA_RAT | ChEBI |
| Target | Raf | Selleck Chemicals |
| Indications | renal cell carcinoma | KeyOrganics Bioactives |
| mechanism | VEGF receptor 2 & 3 kinases and c Kit the receptor for Stem cell factor | IBScreen Bioactives |
| Target | VEGFR, PDGFR, Raf | Selleck Chemicals |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| ABL1-1-E | Tyrosine-protein Kinase ABL (cluster #1 Of 1), Eukaryotic | Eukaryotes | 226 | 0.29 | Binding ≤ 10μM |
| ABL2-1-E | Tyrosine-protein Kinase ABL2 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 2900 | 0.24 | Binding ≤ 10μM |
| AURKA-1-E | Serine/threonine-protein Kinase Aurora-A (cluster #1 Of 3), Eukaryotic | Eukaryotes | 3800 | 0.24 | Binding ≤ 10μM |
| AURKB-1-E | Serine/threonine-protein Kinase Aurora-B (cluster #1 Of 2), Eukaryotic | Eukaryotes | 440 | 0.28 | Binding ≤ 10μM |
| AURKC-1-E | Serine/threonine-protein Kinase Aurora-C (cluster #1 Of 2), Eukaryotic | Eukaryotes | 210 | 0.29 | Binding ≤ 10μM |
| BRAF-1-E | Serine/threonine-protein Kinase B-raf (cluster #1 Of 1), Eukaryotic | Eukaryotes | 76 | 0.31 | Binding ≤ 10μM |
| CDK14-1-E | Serine/threonine-protein Kinase PFTAIRE-1 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 2900 | 0.24 | Binding ≤ 10μM |
| CDK15-1-E | Serine/threonine-protein Kinase PFTAIRE-2 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 2900 | 0.24 | Binding ≤ 10μM |
| CDK17-1-E | Serine/threonine-protein Kinase PCTAIRE-2 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 1600 | 0.25 | Binding ≤ 10μM |
| CDK19-1-E | Cell Division Cycle 2-like Protein Kinase 6 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 250 | 0.29 | Binding ≤ 10μM |
| CDK5-1-E | Cyclin-dependent Kinase 5 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 6200 | 0.23 | Binding ≤ 10μM |
| CDK7-1-E | Cyclin-dependent Kinase 7 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 140 | 0.30 | Binding ≤ 10μM |
| CDK8-1-E | Cell Division Protein Kinase 8 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 310 | 0.28 | Binding ≤ 10μM |
| CDKL2-1-E | Cyclin-dependent Kinase-like 2 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 130 | 0.30 | Binding ≤ 10μM |
| CDKL3-1-E | Cyclin-dependent Kinase-like 3 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 490 | 0.28 | Binding ≤ 10μM |
| CSF1R-1-E | Macrophage Colony-stimulating Factor 1 Receptor (cluster #1 Of 1), Eukaryotic | Eukaryotes | 58 | 0.32 | Binding ≤ 10μM |
| CSK-1-E | Tyrosine-protein Kinase CSK (cluster #1 Of 1), Eukaryotic | Eukaryotes | 2900 | 0.24 | Binding ≤ 10μM |
| CTRO-1-E | Citron Rho-interacting Kinase (cluster #1 Of 1), Eukaryotic | Eukaryotes | 6200 | 0.23 | Binding ≤ 10μM |
| DDR1-1-E | Epithelial Discoidin Domain-containing Receptor 1 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 2 | 0.38 | Binding ≤ 10μM |
| DDR2-1-E | Discoidin Domain-containing Receptor 2 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 7 | 0.36 | Binding ≤ 10μM |
| EPHA1-1-E | Ephrin Type-A Receptor 1 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 3100 | 0.24 | Binding ≤ 10μM |
| EPHA2-1-E | Ephrin Type-A Receptor 2 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 4800 | 0.23 | Binding ≤ 10μM |
| EPHA3-1-E | Ephrin Type-A Receptor 3 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 6400 | 0.23 | Binding ≤ 10μM |
| EPHA4-1-E | Ephrin Type-A Receptor 4 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 3000 | 0.24 | Binding ≤ 10μM |
| EPHA5-1-E | Ephrin Type-A Receptor 5 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 360 | 0.28 | Binding ≤ 10μM |
| EPHA6-1-E | Ephrin Type-A Receptor 6 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 370 | 0.28 | Binding ≤ 10μM |
| EPHA7-1-E | Ephrin Type-A Receptor 7 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 670 | 0.27 | Binding ≤ 10μM |
| EPHA8-1-E | Ephrin Type-A Receptor 8 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 960 | 0.26 | Binding ≤ 10μM |
| EPHB1-1-E | Ephrin Type-B Receptor 1 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 3000 | 0.24 | Binding ≤ 10μM |
| EPHB2-1-E | Ephrin Type-B Receptor 2 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 1900 | 0.25 | Binding ≤ 10μM |
| EPHB4-1-E | Ephrin Type-B Receptor 4 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 3900 | 0.24 | Binding ≤ 10μM |
| EPHB6-1-E | Ephrin Type-B Receptor 6 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 240 | 0.29 | Binding ≤ 10μM |
| FGFR1-1-E | Fibroblast Growth Factor Receptor 1 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 580 | 0.27 | Binding ≤ 10μM |
| FGFR2-1-E | Fibroblast Growth Factor Receptor 2 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 2700 | 0.24 | Binding ≤ 10μM |
| FGFR3-1-E | Fibroblast Growth Factor Receptor 3 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 5900 | 0.23 | Binding ≤ 10μM |
| FLT3-1-E | Tyrosine-protein Kinase Receptor FLT3 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 82 | 0.31 | Binding ≤ 10μM |
| FRK-1-E | Tyrosine-protein Kinase FRK (cluster #1 Of 1), Eukaryotic | Eukaryotes | 510 | 0.28 | Binding ≤ 10μM |
| HCK-1-E | Tyrosine-protein Kinase HCK (cluster #1 Of 1), Eukaryotic | Eukaryotes | 530 | 0.27 | Binding ≤ 10μM |
| HIPK1-1-E | Homeodomain-interacting Protein Kinase 1 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 1100 | 0.26 | Binding ≤ 10μM |
| HIPK2-1-E | Homeodomain-interacting Protein Kinase 2 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 1700 | 0.25 | Binding ≤ 10μM |
| HIPK3-1-E | Homeodomain-interacting Protein Kinase 3 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 390 | 0.28 | Binding ≤ 10μM |
| HIPK4-1-E | Homeodomain-interacting Protein Kinase 4 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 3 | 0.37 | Binding ≤ 10μM |
| INSR-1-E | Insulin Receptor (cluster #1 Of 1), Eukaryotic | Eukaryotes | 5300 | 0.23 | Binding ≤ 10μM |
| KC1A-1-E | Casein Kinase I Alpha (cluster #1 Of 1), Eukaryotic | Eukaryotes | 250 | 0.29 | Binding ≤ 10μM |
| KIT-1-E | Stem Cell Growth Factor Receptor (cluster #1 Of 1), Eukaryotic | Eukaryotes | 740 | 0.27 | Binding ≤ 10μM |
| KS6A6-1-E | Ribosomal Protein S6 Kinase Alpha 6 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 7500 | 0.22 | Binding ≤ 10μM |
| LCK-1-E | Tyrosine-protein Kinase LCK (cluster #1 Of 4), Eukaryotic | Eukaryotes | 6900 | 0.23 | Binding ≤ 10μM |
| LIMK1-1-E | LIM Domain Kinase 1 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 2200 | 0.25 | Binding ≤ 10μM |
| LYN-1-E | Tyrosine-protein Kinase Lyn (cluster #1 Of 1), Eukaryotic | Eukaryotes | 3000 | 0.24 | Binding ≤ 10μM |
| M3K7-1-E | Mitogen-activated Protein Kinase Kinase Kinase 7 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 690 | 0.27 | Binding ≤ 10μM |
| M4K4-1-E | Mitogen-activated Protein Kinase Kinase Kinase Kinase 4 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 4800 | 0.23 | Binding ≤ 10μM |
| M4K5-1-E | Mitogen-activated Protein Kinase Kinase Kinase Kinase 5 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 1700 | 0.25 | Binding ≤ 10μM |
| MERTK-1-E | Proto-oncogene Tyrosine-protein Kinase MER (cluster #1 Of 1), Eukaryotic | Eukaryotes | 3600 | 0.24 | Binding ≤ 10μM |
| MK09-1-E | C-Jun N-terminal Kinase 2 (cluster #1 Of 3), Eukaryotic | Eukaryotes | 3600 | 0.24 | Binding ≤ 10μM |
| MK11-1-E | MAP Kinase P38 Beta (cluster #1 Of 1), Eukaryotic | Eukaryotes | 230 | 0.29 | Binding ≤ 10μM |
| MK12-1-E | MAP Kinase P38 Gamma (cluster #1 Of 2), Eukaryotic | Eukaryotes | 9900 | 0.22 | Binding ≤ 10μM |
| MK13-1-E | MAP Kinase P38 Delta (cluster #1 Of 1), Eukaryotic | Eukaryotes | 6600 | 0.23 | Binding ≤ 10μM |
| MK14-1-E | MAP Kinase P38 Alpha (cluster #1 Of 3), Eukaryotic | Eukaryotes | 85 | 0.31 | Binding ≤ 10μM |
| MK15-1-E | Mitogen-activated Protein Kinase 15 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 46 | 0.32 | Binding ≤ 10μM |
| MKNK1-1-E | MAP Kinase-interacting Serine/threonine-protein Kinase MNK1 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 230 | 0.29 | Binding ≤ 10μM |
| MKNK2-1-E | MAP Kinase Signal-integrating Kinase 2 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 250 | 0.29 | Binding ≤ 10μM |
| MLTK-1-E | Mixed Lineage Kinase 7 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 6 | 0.36 | Binding ≤ 10μM |
| MUSK-1-E | Muscle, Skeletal Receptor Tyrosine Protein Kinase (cluster #1 Of 1), Eukaryotic | Eukaryotes | 130 | 0.30 | Binding ≤ 10μM |
| MYLK2-1-E | Myosin Light Chain Kinase 2 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 1300 | 0.26 | Binding ≤ 10μM |
| NLK-1-E | Serine/threonine Protein Kinase NLK (cluster #1 Of 1), Eukaryotic | Eukaryotes | 640 | 0.27 | Binding ≤ 10μM |
| NTRK1-1-E | Nerve Growth Factor Receptor Trk-A (cluster #1 Of 1), Eukaryotic | Eukaryotes | 6300 | 0.23 | Binding ≤ 10μM |
| NTRK2-1-E | Neurotrophic Tyrosine Kinase Receptor Type 2 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 2100 | 0.25 | Binding ≤ 10μM |
| NTRK3-1-E | NT-3 Growth Factor Receptor (cluster #1 Of 1), Eukaryotic | Eukaryotes | 600 | 0.27 | Binding ≤ 10μM |
| PGFRA-1-E | Platelet-derived Growth Factor Receptor Alpha (cluster #1 Of 2), Eukaryotic | Eukaryotes | 62 | 0.32 | Binding ≤ 10μM |
| PGFRB-1-E | Platelet-derived Growth Factor Receptor Beta (cluster #1 Of 1), Eukaryotic | Eukaryotes | 57 | 0.32 | Binding ≤ 10μM |
| PLK4-1-E | Serine/threonine-protein Kinase PLK4 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 4500 | 0.23 | Binding ≤ 10μM |
| RAF1-1-E | Serine/threonine-protein Kinase RAF (cluster #1 Of 1), Eukaryotic | Eukaryotes | 6 | 0.36 | Binding ≤ 10μM |
| RET-1-E | Tyrosine-protein Kinase Receptor RET (cluster #1 Of 1), Eukaryotic | Eukaryotes | 9 | 0.35 | Binding ≤ 10μM |
| RIPK2-1-E | Serine/threonine-protein Kinase RIPK2 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 3600 | 0.24 | Binding ≤ 10μM |
| SLK-1-E | Serine/threonine-protein Kinase 2 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 1600 | 0.25 | Binding ≤ 10μM |
| SRC-1-E | Tyrosine-protein Kinase SRC (cluster #1 Of 3), Eukaryotic | Eukaryotes | 390 | 0.28 | Binding ≤ 10μM |
| SRMS-1-E | Tyrosine-protein Kinase Srms (cluster #1 Of 1), Eukaryotic | Eukaryotes | 9800 | 0.22 | Binding ≤ 10μM |
| STK10-1-E | Serine/threonine-protein Kinase 10 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 150 | 0.30 | Binding ≤ 10μM |
| STK33-1-E | Serine/threonine-protein Kinase 33 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 2400 | 0.25 | Binding ≤ 10μM |
| STK36-1-E | Serine/threonine-protein Kinase 36 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 5400 | 0.23 | Binding ≤ 10μM |
| TAOK1-1-E | Serine/threonine-protein Kinase TAO1 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 540 | 0.27 | Binding ≤ 10μM |
| TAOK3-1-E | Serine/threonine-protein Kinase TAO3 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 2700 | 0.24 | Binding ≤ 10μM |
| TIE1-1-E | Tyrosine-protein Kinase Receptor Tie-1 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 68 | 0.31 | Binding ≤ 10μM |
| TIE2-1-E | Tyrosine-protein Kinase TIE-2 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 3000 | 0.24 | Binding ≤ 10μM |
| TNI3K-1-E | Serine/threonine-protein Kinase TNNI3K (cluster #1 Of 1), Eukaryotic | Eukaryotes | 280 | 0.29 | Binding ≤ 10μM |
| TNK1-1-E | Non-receptor Tyrosine-protein Kinase TNK1 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 2300 | 0.25 | Binding ≤ 10μM |
| TTK-1-E | Dual Specificity Protein Kinase TTK (cluster #1 Of 2), Eukaryotic | Eukaryotes | 3500 | 0.24 | Binding ≤ 10μM |
| UFO-1-E | Tyrosine-protein Kinase Receptor UFO (cluster #1 Of 1), Eukaryotic | Eukaryotes | 4500 | 0.23 | Binding ≤ 10μM |
| VGFR1-1-E | Vascular Endothelial Growth Factor Receptor 1 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 31 | 0.33 | Binding ≤ 10μM |
| VGFR2-1-E | Vascular Endothelial Growth Factor Receptor 2 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 93 | 0.31 | Binding ≤ 10μM |
| VGFR3-1-E | Vascular Endothelial Growth Factor Receptor 3 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 95 | 0.31 | Binding ≤ 10μM |
| YSK4-1-E | SPS1/STE20-related Protein Kinase YSK4 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 99 | 0.31 | Binding ≤ 10μM |
| BRAF-1-E | Serine/threonine-protein Kinase B-raf (cluster #1 Of 1), Eukaryotic | Eukaryotes | 6100 | 0.23 | Functional ≤ 10μM |
| MP2K1-2-E | Dual Specificity Mitogen-activated Protein Kinase Kinase 1 (cluster #2 Of 2), Eukaryotic | Eukaryotes | 3300 | 0.24 | Functional ≤ 10μM |
| RAF1-2-E | Serine/threonine-protein Kinase RAF (cluster #2 Of 2), Eukaryotic | Eukaryotes | 3300 | 0.24 | Functional ≤ 10μM |
| Z100405-1-O | MV4-11 (Myeloid Leukemia Cells) (cluster #1 Of 1), Other | Other | 15 | 0.34 | Functional ≤ 10μM |
| Z103203-1-O | A375 (cluster #1 Of 3), Other | Other | 5600 | 0.23 | Functional ≤ 10μM |
| Z50425-3-O | Plasmodium Falciparum (cluster #3 Of 22), Other | Other | 509 | 0.28 | Functional ≤ 10μM |
| Z80224-1-O | MCF7 (Breast Carcinoma Cells) (cluster #1 Of 14), Other | Other | 8830 | 0.22 | Functional ≤ 10μM |
| Z80485-1-O | SK-MEL-28 (Melanoma Cells) (cluster #1 Of 6), Other | Other | 1300 | 0.26 | Functional ≤ 10μM |
| Z80548-1-O | THP-1 (Acute Monocytic Leukemia Cells) (cluster #1 Of 5), Other | Other | 310 | 0.28 | Functional ≤ 10μM |
| Z80682-1-O | A549 (Lung Carcinoma Cells) (cluster #1 Of 11), Other | Other | 5210 | 0.23 | Functional ≤ 10μM |
| Z81057-1-O | HUVEC (Umbilical Vein Endothelial Cells) (cluster #1 Of 4), Other | Other | 1 | 0.39 | Functional ≤ 10μM |
| Z81252-3-O | MDA-MB-231 (Breast Adenocarcinoma Cells) (cluster #3 Of 11), Other | Other | 7620 | 0.22 | Functional ≤ 10μM |
| Z100091-1-O | HS27 (Fibroblast Cells) (cluster #1 Of 1), Other | Other | 7850 | 0.22 | ADME/T ≤ 10μM |
| Z103203-1-O | A375 (cluster #1 Of 1), Other | Other | 2200 | 0.25 | ADME/T ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| KC1A_HUMAN | P48729 | Casein Kinase I Alpha, Human | 250 | 0.29 | Binding ≤ 1μM |
| CDK19_HUMAN | Q9BWU1 | Cell Division Cycle 2-like Protein Kinase 6, Human | 250 | 0.29 | Binding ≤ 1μM |
| CDK8_HUMAN | P49336 | Cell Division Protein Kinase 8, Human | 310 | 0.28 | Binding ≤ 1μM |
| CDK7_HUMAN | P50613 | Cyclin-dependent Kinase 7, Human | 140 | 0.30 | Binding ≤ 1μM |
| CDKL2_HUMAN | Q92772 | Cyclin-dependent Kinase-like 2, Human | 130 | 0.30 | Binding ≤ 1μM |
| CDKL3_HUMAN | Q8IVW4 | Cyclin-dependent Kinase-like 3, Human | 490 | 0.28 | Binding ≤ 1μM |
| DDR2_HUMAN | Q16832 | Discoidin Domain-containing Receptor 2, Human | 6.6 | 0.36 | Binding ≤ 1μM |
| EPHA5_HUMAN | P54756 | Ephrin Type-A Receptor 5, Human | 360 | 0.28 | Binding ≤ 1μM |
| EPHA6_HUMAN | Q9UF33 | Ephrin Type-A Receptor 6, Human | 240 | 0.29 | Binding ≤ 1μM |
| EPHA7_HUMAN | Q15375 | Ephrin Type-A Receptor 7, Human | 670 | 0.27 | Binding ≤ 1μM |
| EPHA8_HUMAN | P29322 | Ephrin Type-A Receptor 8, Human | 960 | 0.26 | Binding ≤ 1μM |
| EPHB6_HUMAN | O15197 | Ephrin Type-B Receptor 6, Human | 240 | 0.29 | Binding ≤ 1μM |
| DDR1_HUMAN | Q08345 | Epithelial Discoidin Domain-containing Receptor 1, Human | 1.5 | 0.39 | Binding ≤ 1μM |
| FGFR1_HUMAN | P11362 | Fibroblast Growth Factor Receptor 1, Human | 580 | 0.27 | Binding ≤ 1μM |
| HIPK3_HUMAN | Q9H422 | Homeodomain-interacting Protein Kinase 3, Human | 390 | 0.28 | Binding ≤ 1μM |
| HIPK4_HUMAN | Q8NE63 | Homeodomain-interacting Protein Kinase 4, Human | 2.7 | 0.37 | Binding ≤ 1μM |
| CSF1R_HUMAN | P07333 | Macrophage Colony Stimulating Factor Receptor, Human | 19 | 0.34 | Binding ≤ 1μM |
| MK14_HUMAN | Q16539 | MAP Kinase P38 Alpha, Human | 260 | 0.29 | Binding ≤ 1μM |
| MK11_HUMAN | Q15759 | MAP Kinase P38 Beta, Human | 200 | 0.29 | Binding ≤ 1μM |
| MKNK2_HUMAN | Q9HBH9 | MAP Kinase Signal-integrating Kinase 2, Human | 130 | 0.30 | Binding ≤ 1μM |
| MKNK1_HUMAN | Q9BUB5 | MAP Kinase-interacting Serine/threonine-protein Kinase MNK1, Human | 230 | 0.29 | Binding ≤ 1μM |
| MK15_HUMAN | Q8TD08 | Mitogen-activated Protein Kinase 15, Human | 46 | 0.32 | Binding ≤ 1μM |
| M3K7_HUMAN | O43318 | Mitogen-activated Protein Kinase Kinase Kinase 7, Human | 690 | 0.27 | Binding ≤ 1μM |
| MLTK_HUMAN | Q9NYL2 | Mixed Lineage Kinase 7, Human | 6.3 | 0.36 | Binding ≤ 1μM |
| MUSK_HUMAN | O15146 | Muscle, Skeletal Receptor Tyrosine Protein Kinase, Human | 130 | 0.30 | Binding ≤ 1μM |
| NTRK3_HUMAN | Q16288 | NT-3 Growth Factor Receptor, Human | 600 | 0.27 | Binding ≤ 1μM |
| PGFRA_HUMAN | P16234 | Platelet-derived Growth Factor Receptor Alpha, Human | 62 | 0.32 | Binding ≤ 1μM |
| PGFRB_HUMAN | P09619 | Platelet-derived Growth Factor Receptor Beta, Human | 10 | 0.35 | Binding ≤ 1μM |
| NLK_HUMAN | Q9UBE8 | Serine/threonine Protein Kinase NLK, Human | 640 | 0.27 | Binding ≤ 1μM |
| STK10_HUMAN | O94804 | Serine/threonine-protein Kinase 10, Human | 140 | 0.30 | Binding ≤ 1μM |
| SLK_HUMAN | Q9H2G2 | Serine/threonine-protein Kinase 2, Human | 1000 | 0.26 | Binding ≤ 1μM |
| AURKB_HUMAN | Q96GD4 | Serine/threonine-protein Kinase Aurora-B, Human | 440 | 0.28 | Binding ≤ 1μM |
| AURKC_HUMAN | Q9UQB9 | Serine/threonine-protein Kinase Aurora-C, Human | 210 | 0.29 | Binding ≤ 1μM |
| BRAF_HUMAN | P15056 | Serine/threonine-protein Kinase B-raf, Human | 15 | 0.34 | Binding ≤ 1μM |
| RAF1_HUMAN | P04049 | Serine/threonine-protein Kinase RAF, Human | 1 | 0.39 | Binding ≤ 1μM |
| TAOK1_HUMAN | Q7L7X3 | Serine/threonine-protein Kinase TAO1, Human | 540 | 0.27 | Binding ≤ 1μM |
| TNI3K_HUMAN | Q59H18 | Serine/threonine-protein Kinase TNNI3K, Human | 280 | 0.29 | Binding ≤ 1μM |
| YSK4_HUMAN | Q56UN5 | SPS1/STE20-related Protein Kinase YSK4, Human | 99 | 0.31 | Binding ≤ 1μM |
| KIT_HUMAN | P10721 | Stem Cell Growth Factor Receptor, Human | 10 | 0.35 | Binding ≤ 1μM |
| ABL1_MOUSE | P00520 | Tyrosine-protein Kinase ABL, Mouse | 225.9 | 0.29 | Binding ≤ 1μM |
| ABL1_HUMAN | P00519 | Tyrosine-protein Kinase ABL, Human | 120 | 0.30 | Binding ≤ 1μM |
| FRK_HUMAN | P42685 | Tyrosine-protein Kinase FRK, Human | 440 | 0.28 | Binding ≤ 1μM |
| HCK_HUMAN | P08631 | Tyrosine-protein Kinase HCK, Human | 530 | 0.27 | Binding ≤ 1μM |
| LCK_HUMAN | P06239 | Tyrosine-protein Kinase LCK, Human | 60 | 0.32 | Binding ≤ 1μM |
| FLT3_HUMAN | P36888 | Tyrosine-protein Kinase Receptor FLT3, Human | 11 | 0.35 | Binding ≤ 1μM |
| RET_HUMAN | P07949 | Tyrosine-protein Kinase Receptor RET, Human | 13 | 0.35 | Binding ≤ 1μM |
| TIE1_HUMAN | P35590 | Tyrosine-protein Kinase Receptor Tie-1, Human | 68 | 0.31 | Binding ≤ 1μM |
| SRC_HUMAN | P12931 | Tyrosine-protein Kinase SRC, Human | 390 | 0.28 | Binding ≤ 1μM |
| VGFR1_HUMAN | P17948 | Vascular Endothelial Growth Factor Receptor 1, Human | 18 | 0.34 | Binding ≤ 1μM |
| VGFR2_HUMAN | P35968 | Vascular Endothelial Growth Factor Receptor 2, Human | 0.1 | 0.44 | Binding ≤ 1μM |
| VGFR3_HUMAN | P35916 | Vascular Endothelial Growth Factor Receptor 3, Human | 16 | 0.34 | Binding ≤ 1μM |
| MK09_HUMAN | P45984 | C-Jun N-terminal Kinase 2, Human | 3600 | 0.24 | Binding ≤ 10μM |
| KC1A_HUMAN | P48729 | Casein Kinase I Alpha, Human | 250 | 0.29 | Binding ≤ 10μM |
| CDK19_HUMAN | Q9BWU1 | Cell Division Cycle 2-like Protein Kinase 6, Human | 250 | 0.29 | Binding ≤ 10μM |
| CDK8_HUMAN | P49336 | Cell Division Protein Kinase 8, Human | 310 | 0.28 | Binding ≤ 10μM |
| CTRO_HUMAN | O14578 | Citron Rho-interacting Kinase, Human | 6200 | 0.23 | Binding ≤ 10μM |
| CDK5_HUMAN | Q00535 | Cyclin-dependent Kinase 5, Human | 6200 | 0.23 | Binding ≤ 10μM |
| CDK7_HUMAN | P50613 | Cyclin-dependent Kinase 7, Human | 140 | 0.30 | Binding ≤ 10μM |
| CDKL2_HUMAN | Q92772 | Cyclin-dependent Kinase-like 2, Human | 130 | 0.30 | Binding ≤ 10μM |
| CDKL3_HUMAN | Q8IVW4 | Cyclin-dependent Kinase-like 3, Human | 490 | 0.28 | Binding ≤ 10μM |
| DDR2_HUMAN | Q16832 | Discoidin Domain-containing Receptor 2, Human | 6.6 | 0.36 | Binding ≤ 10μM |
| TTK_HUMAN | P33981 | Dual Specificity Protein Kinase TTK, Human | 3500 | 0.24 | Binding ≤ 10μM |
| EPHA1_HUMAN | P21709 | Ephrin Type-A Receptor 1, Human | 3100 | 0.24 | Binding ≤ 10μM |
| EPHA2_HUMAN | P29317 | Ephrin Type-A Receptor 2, Human | 2000 | 0.25 | Binding ≤ 10μM |
| EPHA3_HUMAN | P29320 | Ephrin Type-A Receptor 3, Human | 1900 | 0.25 | Binding ≤ 10μM |
| EPHA4_HUMAN | P54764 | Ephrin Type-A Receptor 4, Human | 1300 | 0.26 | Binding ≤ 10μM |
| EPHA5_HUMAN | P54756 | Ephrin Type-A Receptor 5, Human | 360 | 0.28 | Binding ≤ 10μM |
| EPHA6_HUMAN | Q9UF33 | Ephrin Type-A Receptor 6, Human | 240 | 0.29 | Binding ≤ 10μM |
| EPHA7_HUMAN | Q15375 | Ephrin Type-A Receptor 7, Human | 5300 | 0.23 | Binding ≤ 10μM |
| EPHA8_HUMAN | P29322 | Ephrin Type-A Receptor 8, Human | 2400 | 0.25 | Binding ≤ 10μM |
| EPHB1_HUMAN | P54762 | Ephrin Type-B Receptor 1, Human | 1700 | 0.25 | Binding ≤ 10μM |
| EPHB2_HUMAN | P29323 | Ephrin Type-B Receptor 2, Human | 1900 | 0.25 | Binding ≤ 10μM |
| EPHB4_HUMAN | P54760 | Ephrin Type-B Receptor 4, Human | 1800 | 0.25 | Binding ≤ 10μM |
| EPHB6_HUMAN | O15197 | Ephrin Type-B Receptor 6, Human | 240 | 0.29 | Binding ≤ 10μM |
| DDR1_HUMAN | Q08345 | Epithelial Discoidin Domain-containing Receptor 1, Human | 1.5 | 0.39 | Binding ≤ 10μM |
| FGFR1_HUMAN | P11362 | Fibroblast Growth Factor Receptor 1, Human | 2500 | 0.25 | Binding ≤ 10μM |
| FGFR2_HUMAN | P21802 | Fibroblast Growth Factor Receptor 2, Human | 2700 | 0.24 | Binding ≤ 10μM |
| FGFR3_HUMAN | P22607 | Fibroblast Growth Factor Receptor 3, Human | 5900 | 0.23 | Binding ≤ 10μM |
| HIPK1_HUMAN | Q86Z02 | Homeodomain-interacting Protein Kinase 1, Human | 1100 | 0.26 | Binding ≤ 10μM |
| HIPK2_HUMAN | Q9H2X6 | Homeodomain-interacting Protein Kinase 2, Human | 1700 | 0.25 | Binding ≤ 10μM |
| HIPK3_HUMAN | Q9H422 | Homeodomain-interacting Protein Kinase 3, Human | 390 | 0.28 | Binding ≤ 10μM |
| HIPK4_HUMAN | Q8NE63 | Homeodomain-interacting Protein Kinase 4, Human | 2.7 | 0.37 | Binding ≤ 10μM |
| INSR_HUMAN | P06213 | Insulin Receptor, Human | 5300 | 0.23 | Binding ≤ 10μM |
| LIMK1_HUMAN | P53667 | LIM Domain Kinase 1, Human | 1600 | 0.25 | Binding ≤ 10μM |
| CSF1R_HUMAN | P07333 | Macrophage Colony Stimulating Factor Receptor, Human | 19 | 0.34 | Binding ≤ 10μM |
| MK14_HUMAN | Q16539 | MAP Kinase P38 Alpha, Human | 1100 | 0.26 | Binding ≤ 10μM |
| MK11_HUMAN | Q15759 | MAP Kinase P38 Beta, Human | 200 | 0.29 | Binding ≤ 10μM |
| MK13_HUMAN | O15264 | MAP Kinase P38 Delta, Human | 6600 | 0.23 | Binding ≤ 10μM |
| MK12_HUMAN | P53778 | MAP Kinase P38 Gamma, Human | 7600 | 0.22 | Binding ≤ 10μM |
| MKNK2_HUMAN | Q9HBH9 | MAP Kinase Signal-integrating Kinase 2, Human | 130 | 0.30 | Binding ≤ 10μM |
| MKNK1_HUMAN | Q9BUB5 | MAP Kinase-interacting Serine/threonine-protein Kinase MNK1, Human | 230 | 0.29 | Binding ≤ 10μM |
| MK15_HUMAN | Q8TD08 | Mitogen-activated Protein Kinase 15, Human | 46 | 0.32 | Binding ≤ 10μM |
| M3K7_HUMAN | O43318 | Mitogen-activated Protein Kinase Kinase Kinase 7, Human | 690 | 0.27 | Binding ≤ 10μM |
| M4K4_HUMAN | O95819 | Mitogen-activated Protein Kinase Kinase Kinase Kinase 4, Human | 4800 | 0.23 | Binding ≤ 10μM |
| M4K5_HUMAN | Q9Y4K4 | Mitogen-activated Protein Kinase Kinase Kinase Kinase 5, Human | 1600 | 0.25 | Binding ≤ 10μM |
| MLTK_HUMAN | Q9NYL2 | Mixed Lineage Kinase 7, Human | 6.3 | 0.36 | Binding ≤ 10μM |
| MUSK_HUMAN | O15146 | Muscle, Skeletal Receptor Tyrosine Protein Kinase, Human | 130 | 0.30 | Binding ≤ 10μM |
| MYLK2_HUMAN | Q9H1R3 | Myosin Light Chain Kinase 2, Human | 1300 | 0.26 | Binding ≤ 10μM |
| NTRK1_HUMAN | P04629 | Nerve Growth Factor Receptor Trk-A, Human | 3600 | 0.24 | Binding ≤ 10μM |
| NTRK2_HUMAN | Q16620 | Neurotrophic Tyrosine Kinase Receptor Type 2, Human | 2100 | 0.25 | Binding ≤ 10μM |
| TNK1_HUMAN | Q13470 | Non-receptor Tyrosine-protein Kinase TNK1, Human | 2300 | 0.25 | Binding ≤ 10μM |
| NTRK3_HUMAN | Q16288 | NT-3 Growth Factor Receptor, Human | 600 | 0.27 | Binding ≤ 10μM |
| PGFRA_HUMAN | P16234 | Platelet-derived Growth Factor Receptor Alpha, Human | 62 | 0.32 | Binding ≤ 10μM |
| PGFRB_HUMAN | P09619 | Platelet-derived Growth Factor Receptor Beta, Human | 10 | 0.35 | Binding ≤ 10μM |
| MERTK_HUMAN | Q12866 | Proto-oncogene Tyrosine-protein Kinase MER, Human | 3600 | 0.24 | Binding ≤ 10μM |
| KS6A6_HUMAN | Q9UK32 | Ribosomal Protein S6 Kinase Alpha 6, Human | 7500 | 0.22 | Binding ≤ 10μM |
| NLK_HUMAN | Q9UBE8 | Serine/threonine Protein Kinase NLK, Human | 640 | 0.27 | Binding ≤ 10μM |
| STK10_HUMAN | O94804 | Serine/threonine-protein Kinase 10, Human | 140 | 0.30 | Binding ≤ 10μM |
| SLK_HUMAN | Q9H2G2 | Serine/threonine-protein Kinase 2, Human | 1000 | 0.26 | Binding ≤ 10μM |
| STK33_HUMAN | Q9BYT3 | Serine/threonine-protein Kinase 33, Human | 2400 | 0.25 | Binding ≤ 10μM |
| STK36_HUMAN | Q9NRP7 | Serine/threonine-protein Kinase 36, Human | 3800 | 0.24 | Binding ≤ 10μM |
| AURKA_HUMAN | O14965 | Serine/threonine-protein Kinase Aurora-A, Human | 3800 | 0.24 | Binding ≤ 10μM |
| AURKB_HUMAN | Q96GD4 | Serine/threonine-protein Kinase Aurora-B, Human | 440 | 0.28 | Binding ≤ 10μM |
| AURKC_HUMAN | Q9UQB9 | Serine/threonine-protein Kinase Aurora-C, Human | 210 | 0.29 | Binding ≤ 10μM |
| BRAF_HUMAN | P15056 | Serine/threonine-protein Kinase B-raf, Human | 15 | 0.34 | Binding ≤ 10μM |
| CDK17_HUMAN | Q00537 | Serine/threonine-protein Kinase PCTAIRE-2, Human | 1600 | 0.25 | Binding ≤ 10μM |
| CDK14_HUMAN | O94921 | Serine/threonine-protein Kinase PFTAIRE-1, Human | 2900 | 0.24 | Binding ≤ 10μM |
| CDK15_HUMAN | Q96Q40 | Serine/threonine-protein Kinase PFTAIRE-2, Human | 2900 | 0.24 | Binding ≤ 10μM |
| PLK4_HUMAN | O00444 | Serine/threonine-protein Kinase PLK4, Human | 3400 | 0.24 | Binding ≤ 10μM |
| RAF1_HUMAN | P04049 | Serine/threonine-protein Kinase RAF, Human | 1 | 0.39 | Binding ≤ 10μM |
| RIPK2_HUMAN | O43353 | Serine/threonine-protein Kinase RIPK2, Human | 1300 | 0.26 | Binding ≤ 10μM |
| TAOK1_HUMAN | Q7L7X3 | Serine/threonine-protein Kinase TAO1, Human | 540 | 0.27 | Binding ≤ 10μM |
| TAOK3_HUMAN | Q9H2K8 | Serine/threonine-protein Kinase TAO3, Human | 2700 | 0.24 | Binding ≤ 10μM |
| TNI3K_HUMAN | Q59H18 | Serine/threonine-protein Kinase TNNI3K, Human | 280 | 0.29 | Binding ≤ 10μM |
| YSK4_HUMAN | Q56UN5 | SPS1/STE20-related Protein Kinase YSK4, Human | 99 | 0.31 | Binding ≤ 10μM |
| KIT_HUMAN | P10721 | Stem Cell Growth Factor Receptor, Human | 10 | 0.35 | Binding ≤ 10μM |
| ABL1_MOUSE | P00520 | Tyrosine-protein Kinase ABL, Mouse | 225.9 | 0.29 | Binding ≤ 10μM |
| ABL1_HUMAN | P00519 | Tyrosine-protein Kinase ABL, Human | 120 | 0.30 | Binding ≤ 10μM |
| ABL2_HUMAN | P42684 | Tyrosine-protein Kinase ABL2, Human | 1300 | 0.26 | Binding ≤ 10μM |
| CSK_HUMAN | P41240 | Tyrosine-protein Kinase CSK, Human | 2900 | 0.24 | Binding ≤ 10μM |
| FRK_HUMAN | P42685 | Tyrosine-protein Kinase FRK, Human | 440 | 0.28 | Binding ≤ 10μM |
| HCK_HUMAN | P08631 | Tyrosine-protein Kinase HCK, Human | 530 | 0.27 | Binding ≤ 10μM |
| LCK_HUMAN | P06239 | Tyrosine-protein Kinase LCK, Human | 2700 | 0.24 | Binding ≤ 10μM |
| LYN_HUMAN | P07948 | Tyrosine-protein Kinase Lyn, Human | 3000 | 0.24 | Binding ≤ 10μM |
| FLT3_HUMAN | P36888 | Tyrosine-protein Kinase Receptor FLT3, Human | 11 | 0.35 | Binding ≤ 10μM |
| RET_HUMAN | P07949 | Tyrosine-protein Kinase Receptor RET, Human | 13 | 0.35 | Binding ≤ 10μM |
| TIE1_HUMAN | P35590 | Tyrosine-protein Kinase Receptor Tie-1, Human | 68 | 0.31 | Binding ≤ 10μM |
| UFO_HUMAN | P30530 | Tyrosine-protein Kinase Receptor UFO, Human | 4500 | 0.23 | Binding ≤ 10μM |
| SRC_HUMAN | P12931 | Tyrosine-protein Kinase SRC, Human | 390 | 0.28 | Binding ≤ 10μM |
| SRMS_HUMAN | Q9H3Y6 | Tyrosine-protein Kinase Srms, Human | 9800 | 0.22 | Binding ≤ 10μM |
| TIE2_HUMAN | Q02763 | Tyrosine-protein Kinase TIE-2, Human | 2100 | 0.25 | Binding ≤ 10μM |
| VGFR1_HUMAN | P17948 | Vascular Endothelial Growth Factor Receptor 1, Human | 18 | 0.34 | Binding ≤ 10μM |
| VGFR2_HUMAN | P35968 | Vascular Endothelial Growth Factor Receptor 2, Human | 0.1 | 0.44 | Binding ≤ 10μM |
| VGFR3_HUMAN | P35916 | Vascular Endothelial Growth Factor Receptor 3, Human | 16 | 0.34 | Binding ≤ 10μM |
| Z103203 | Z103203 | A375 | 5400 | 0.23 | Functional ≤ 10μM |
| Z80682 | Z80682 | A549 (Lung Carcinoma Cells) | 5210 | 0.23 | Functional ≤ 10μM |
| MP2K1_HUMAN | Q02750 | Dual Specificity Mitogen-activated Protein Kinase Kinase 1, Human | 3300 | 0.24 | Functional ≤ 10μM |
| Z81057 | Z81057 | HUVEC (Umbilical Vein Endothelial Cells) | 0.59 | 0.40 | Functional ≤ 10μM |
| Z80224 | Z80224 | MCF7 (Breast Carcinoma Cells) | 8830 | 0.22 | Functional ≤ 10μM |
| Z81252 | Z81252 | MDA-MB-231 (Breast Adenocarcinoma Cells) | 4770 | 0.23 | Functional ≤ 10μM |
| Z100405 | Z100405 | MV4-11 (Myeloid Leukemia Cells) | 0.87 | 0.40 | Functional ≤ 10μM |
| Z50425 | Z50425 | Plasmodium Falciparum | 328 | 0.28 | Functional ≤ 10μM |
| BRAF_HUMAN | P15056 | Serine/threonine-protein Kinase B-raf, Human | 6100 | 0.23 | Functional ≤ 10μM |
| RAF1_HUMAN | P04049 | Serine/threonine-protein Kinase RAF, Human | 3300 | 0.24 | Functional ≤ 10μM |
| Z80485 | Z80485 | SK-MEL-28 (Melanoma Cells) | 1300 | 0.26 | Functional ≤ 10μM |
| Z80548 | Z80548 | THP-1 (Acute Monocytic Leukemia Cells) | 310 | 0.28 | Functional ≤ 10μM |
| Z103203 | Z103203 | A375 | 2200 | 0.25 | ADME/T ≤ 10μM |
| Z100091 | Z100091 | HS27 (Fibroblast Cells) | 7800 | 0.22 | ADME/T ≤ 10μM |
| Description | Species |
|---|---|
| Activated point mutants of FGFR2 | |
| activated TAK1 mediates p38 MAPK activation | |
| Activation of NF-kappaB in B cells | |
| Activation of PPARGC1A (PGC-1alpha) by phosphorylation | |
| Activation of the AP-1 family of transcription factors | |
| ADP signalling through P2Y purinoceptor 1 | |
| Antigen activates B Cell Receptor (BCR) leading to generation of second messenge | |
| APC truncation mutants have impaired AXIN binding | |
| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins | |
| ARMS-mediated activation | |
| AXIN missense mutants destabilize the destruction complex | |
| Beta-catenin phosphorylation cascade | |
| Ca2+ pathway | |
| CD28 co-stimulation | |
| CD28 dependent PI3K/Akt signaling | |
| CD28 dependent Vav1 pathway | |
| CDO in myogenesis | |
| Cell surface interactions at the vascular wall | |
| Constitutive PI3K/AKT Signaling in Cancer | |
| Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | |
| Constitutive Signaling by NOTCH1 PEST Domain Mutants | |
| CREB phosphorylation through the activation of Ras | |
| CRMPs in Sema3A signaling | |
| CTLA4 inhibitory signaling | |
| Cyclin A/B1 associated events during G2/M transition | |
| Cyclin A:Cdk2-associated events at S phase entry | |
| Cyclin D associated events in G1 | |
| Cyclin E associated events during G1/S transition | |
| DAP12 signaling | |
| DARPP-32 events | |
| Degradation of beta-catenin by the destruction complex | |
| disassembly of the destruction complex and recruitment of AXIN to the membrane | |
| Downstream signal transduction | |
| Downstream TCR signaling | |
| DSCAM interactions | |
| Dual incision reaction in GG-NER | |
| Dual incision reaction in TC-NER | |
| ECM proteoglycans | |
| EPH-ephrin mediated repulsion of cells | |
| EPH-Ephrin signaling | |
| EPHA-mediated growth cone collapse | |
| EPHB-mediated forward signaling | |
| Ephrin signaling | |
| ERK/MAPK targets | |
| ERK1 activation | |
| Factors involved in megakaryocyte development and platelet production | |
| Fc epsilon receptor (FCERI) signaling | |
| FCERI mediated Ca+2 mobilization | |
| FCERI mediated MAPK activation | |
| FCERI mediated NF-kB activation | |
| FCGR activation | |
| Formation of HIV elongation complex in the absence of HIV Tat | |
| Formation of HIV-1 elongation complex containing HIV-1 Tat | |
| Formation of incision complex in GG-NER | |
| Formation of RNA Pol II elongation complex | |
| Formation of the Early Elongation Complex | |
| Formation of the HIV-1 Early Elongation Complex | |
| Formation of transcription-coupled NER (TC-NER) repair complex | |
| Frs2-mediated activation | |
| GAB1 signalosome | |
| Generation of second messenger molecules | |
| Generic Transcription Pathway | |
| GP1b-IX-V activation signalling | |
| GPVI-mediated activation cascade | |
| Growth hormone receptor signaling | |
| HIV Transcription Initiation | |
| Insulin receptor recycling | |
| Integrin alphaIIb beta3 signaling | |
| Integrin cell surface interactions | |
| Interleukin-1 signaling | |
| Interleukin-2 signaling | |
| IRAK2 mediated activation of TAK1 complex | |
| IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | |
| IRS activation | |
| JNK (c-Jun kinases) phosphorylation and activation mediated by activated human | |
| KSRP destabilizes mRNA | |
| L1CAM interactions | |
| Loss of Nlp from mitotic centrosomes | |
| Loss of proteins required for interphase microtubule organization from the ce | |
| MEK activation | |
| misspliced GSK3beta mutants stabilize beta-catenin | |
| Mitotic Prometaphase | |
| mRNA Capping | |
| Nef and signal transduction | |
| Nef Mediated CD4 Down-regulation | |
| Neurophilin interactions with VEGF and VEGFR | |
| NGF-independant TRKA activation | |
| NOD1/2 Signaling Pathway | |
| Non-integrin membrane-ECM interactions | |
| NoRC negatively regulates rRNA expression | |
| NOTCH1 Intracellular Domain Regulates Transcription | |
| Oxidative Stress Induced Senescence | |
| p38MAPK events | |
| p75NTR recruits signalling complexes | |
| PD-1 signaling | |
| PECAM1 interactions | |
| Phosphorylation of CD3 and TCR zeta chains | |
| PI3K/AKT activation | |
| PIP3 activates AKT signaling | |
| Platelet Adhesion to exposed collagen | |
| Platelet sensitization by LDL | |
| PLC-gamma1 signalling | |
| POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation | |
| PPARA activates gene expression | |
| RAF activation | |
| RAF phosphorylates MEK | |
| Rap1 signalling | |
| Recruitment of mitotic centrosome proteins and complexes | |
| Recycling pathway of L1 | |
| Regulation of actin dynamics for phagocytic cup formation | |
| Regulation of KIT signaling | |
| Regulation of PLK1 Activity at G2/M Transition | |
| Regulation of signaling by CBL | |
| Resolution of Sister Chromatid Cohesion | |
| Retrograde neurotrophin signalling | |
| RNA Pol II CTD phosphorylation and interaction with CE | |
| RNA Polymerase I Chain Elongation | |
| RNA Polymerase I Promoter Escape | |
| RNA Polymerase I Transcription Initiation | |
| RNA Polymerase I Transcription Termination | |
| RNA Polymerase II HIV Promoter Escape | |
| RNA Polymerase II Pre-transcription Events | |
| RNA Polymerase II Promoter Escape | |
| RNA Polymerase II Transcription Elongation | |
| RNA Polymerase II Transcription Initiation | |
| RNA Polymerase II Transcription Initiation And Promoter Clearance | |
| RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | |
| Role of Abl in Robo-Slit signaling | |
| Role of LAT2/NTAL/LAB on calcium mobilization | |
| RSK activation | |
| S33 mutants of beta-catenin aren't phosphorylated | |
| S37 mutants of beta-catenin aren't phosphorylated | |
| S45 mutants of beta-catenin aren't phosphorylated | |
| Sema3A PAK dependent Axon repulsion | |
| Sema4D induced cell migration and growth-cone collapse | |
| Separation of Sister Chromatids | |
| SHC activation | |
| Signal attenuation | |
| Signal transduction by L1 | |
| Signaling by activated point mutants of FGFR1 | |
| Signaling by activated point mutants of FGFR3 | |
| Signaling by ERBB2 | |
| Signaling by FGFR | |
| Signaling by FGFR mutants | |
| Signaling by FGFR2 amplification mutants | |
| Signaling by FGFR3 mutants | |
| Signaling by Insulin receptor | |
| Signaling by PDGF | |
| Signaling by SCF-KIT | |
| Signalling to p38 via RIT and RIN | |
| Signalling to RAS | |
| Signalling to STAT3 | |
| SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | |
| Spry regulation of FGF signaling | |
| Stimuli-sensing channels | |
| t(4;14) translocations of FGFR3 | |
| T41 mutants of beta-catenin aren't phosphorylated | |
| TAK1 activates NFkB by phosphorylation and activation of IKKs complex | |
| Tat-mediated elongation of the HIV-1 transcript | |
| Tie2 Signaling | |
| TRAF6 mediated induction of TAK1 complex | |
| Transcription of the HIV genome | |
| Transcriptional regulation of white adipocyte differentiation | |
| Translocation of ZAP-70 to Immunological synapse | |
| TRKA activation by NGF | |
| truncations of AMER1 destabilize the destruction complex | |
| Uptake and function of anthrax toxins | |
| VEGF binds to VEGFR leading to receptor dimerization | |
| VEGFA-VEGFR2 Pathway | |
| VEGFR2 mediated cell proliferation |
