Note Type	Comments	Provided By
ALOGPS_SOLUBILITY	7.16e-02 g/l	DrugBank-approved
purity	9.500000000000000e+001	Enamine Building Blocks Enamine Building Blocks
Purity	97%	Fluorochem
Therapy	antineoplastic, histone deacetylase inhibitor	SMDC Pharmakon
UniProt Database Links	AR13B_MOUSE; CDK20_DANRE; CDK20_HUMAN; CDK20_MACMU; CDK20_MOUSE; CDK20_PONAB; CDK20_RAT; CDON_HUMAN; CDON_MOUSE; CDON_RAT; CER1_CHICK; CLUA1_MOUSE; DISP1_MOUSE; FGF4_CHICK; FZD10_CHICK; GDF6B_DANRE; GLI1_CHICK; GLI1_HUMAN; GLI1_MOUSE; GLI1_XENLA; GLI2_CHI	ChEBI
Indications	cutaneous T-cell lymphoma	KeyOrganics Bioactives
Target	HDAC	Selleck Chemicals

Activity (Go SEA)

Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
HDAH-1-B	Histone Deacetylase-like Amidohydrolase (cluster #1 Of 2), Bacterial	Bacteria	1300	0.43	Binding ≤ 10μM
B1WBY8-1-E	Histone Deacetylase 2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	440	0.47	Binding ≤ 10μM
HDA10-1-E	Histone Deacetylase 10 (cluster #1 Of 3), Eukaryotic	Eukaryotes	72	0.53	Binding ≤ 10μM
HDA11-3-E	Histone Deacetylase 11 (cluster #3 Of 3), Eukaryotic	Eukaryotes	50	0.54	Binding ≤ 10μM
HDAC1-3-E	Histone Deacetylase 1 (cluster #3 Of 4), Eukaryotic	Eukaryotes	440	0.47	Binding ≤ 10μM
HDAC2-4-E	Histone Deacetylase 2 (cluster #4 Of 4), Eukaryotic	Eukaryotes	921	0.44	Binding ≤ 10μM
HDAC3-2-E	Histone Deacetylase 3 (cluster #2 Of 3), Eukaryotic	Eukaryotes	440	0.47	Binding ≤ 10μM
HDAC4-2-E	Histone Deacetylase 4 (cluster #2 Of 3), Eukaryotic	Eukaryotes	440	0.47	Binding ≤ 10μM
HDAC5-1-E	Histone Deacetylase 5 (cluster #1 Of 3), Eukaryotic	Eukaryotes	50	0.54	Binding ≤ 10μM
HDAC6-2-E	Histone Deacetylase 6 (cluster #2 Of 3), Eukaryotic	Eukaryotes	90	0.52	Binding ≤ 10μM
HDAC7-3-E	Histone Deacetylase 7 (cluster #3 Of 3), Eukaryotic	Eukaryotes	440	0.47	Binding ≤ 10μM
HDAC8-1-E	Histone Deacetylase 8 (cluster #1 Of 4), Eukaryotic	Eukaryotes	820	0.45	Binding ≤ 10μM
HDAC9-3-E	Histone Deacetylase 9 (cluster #3 Of 3), Eukaryotic	Eukaryotes	65	0.53	Binding ≤ 10μM
NCOR2-1-E	Nuclear Receptor Corepressor 2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	34	0.55	Binding ≤ 10μM
Q5RJZ2-1-E	Histone Deacetylase 5 (cluster #1 Of 1), Eukaryotic	Eukaryotes	440	0.47	Binding ≤ 10μM
Q7K6A1-1-E	Histone Deacetylase (cluster #1 Of 1), Eukaryotic	Eukaryotes	100	0.52	Binding ≤ 10μM
Q94F81-1-E	Histone Deacetylase HD2 (cluster #1 Of 1), Eukaryotic	Eukaryotes	50	0.54	Binding ≤ 10μM
Q99P97-1-E	Histone Deacetylase 6 (cluster #1 Of 1), Eukaryotic	Eukaryotes	440	0.47	Binding ≤ 10μM
Q9XYC7-1-E	Histone Deacetylase (cluster #1 Of 1), Eukaryotic	Eukaryotes	59	0.53	Binding ≤ 10μM
Q9ZTP8-1-E	Histone Deacetylase HD1B (cluster #1 Of 1), Eukaryotic	Eukaryotes	30	0.55	Binding ≤ 10μM
HDA10-1-E	Histone Deacetylase 10 (cluster #1 Of 1), Eukaryotic	Eukaryotes	7200	0.38	Functional ≤ 10μM
HDA11-1-E	Histone Deacetylase 11 (cluster #1 Of 1), Eukaryotic	Eukaryotes	7200	0.38	Functional ≤ 10μM
HDAC1-1-E	Histone Deacetylase 1 (cluster #1 Of 2), Eukaryotic	Eukaryotes	7200	0.38	Functional ≤ 10μM
HDAC2-1-E	Histone Deacetylase 2 (cluster #1 Of 2), Eukaryotic	Eukaryotes	7200	0.38	Functional ≤ 10μM
HDAC3-1-E	Histone Deacetylase 3 (cluster #1 Of 2), Eukaryotic	Eukaryotes	7200	0.38	Functional ≤ 10μM
HDAC4-1-E	Histone Deacetylase 4 (cluster #1 Of 2), Eukaryotic	Eukaryotes	7200	0.38	Functional ≤ 10μM
HDAC5-1-E	Histone Deacetylase 5 (cluster #1 Of 2), Eukaryotic	Eukaryotes	7200	0.38	Functional ≤ 10μM
HDAC6-1-E	Histone Deacetylase 6 (cluster #1 Of 1), Eukaryotic	Eukaryotes	7200	0.38	Functional ≤ 10μM
HDAC7-1-E	Histone Deacetylase 7 (cluster #1 Of 2), Eukaryotic	Eukaryotes	7200	0.38	Functional ≤ 10μM
HDAC8-1-E	Histone Deacetylase 8 (cluster #1 Of 2), Eukaryotic	Eukaryotes	7200	0.38	Functional ≤ 10μM
HDAC9-1-E	Histone Deacetylase 9 (cluster #1 Of 2), Eukaryotic	Eukaryotes	7200	0.38	Functional ≤ 10μM
Q94F81-2-E	Histone Deacetylase HD2 (cluster #2 Of 2), Eukaryotic	Eukaryotes	50	0.54	Functional ≤ 10μM
Z102015-1-O	Plasmodium Vivax (cluster #1 Of 1), Other	Other	170	0.50	Functional ≤ 10μM
Z103205-2-O	A431 (cluster #2 Of 4), Other	Other	4200	0.40	Functional ≤ 10μM
Z103348-2-O	NCI-H2122 (cluster #2 Of 2), Other	Other	7500	0.38	Functional ≤ 10μM
Z50136-2-O	Plasmodium Falciparum (isolate FcB1 / Columbia) (cluster #2 Of 3), Other	Other	820	0.45	Functional ≤ 10μM
Z50425-5-O	Plasmodium Falciparum (cluster #5 Of 22), Other	Other	800	0.45	Functional ≤ 10μM
Z80054-4-O	Caco-2 (Colon Adenocarcinoma Cells) (cluster #4 Of 4), Other	Other	8100	0.38	Functional ≤ 10μM
Z80064-7-O	CCRF-CEM (T-cell Leukemia) (cluster #7 Of 9), Other	Other	950	0.44	Functional ≤ 10μM
Z80125-1-O	DU-145 (Prostate Carcinoma) (cluster #1 Of 9), Other	Other	2120	0.42	Functional ≤ 10μM
Z80156-4-O	HL-60 (Promyeloblast Leukemia Cells) (cluster #4 Of 12), Other	Other	1200	0.44	Functional ≤ 10μM
Z80164-1-O	HT-1080 (Fibrosarcoma Cells) (cluster #1 Of 6), Other	Other	2400	0.41	Functional ≤ 10μM
Z80166-4-O	HT-29 (Colon Adenocarcinoma Cells) (cluster #4 Of 12), Other	Other	2000	0.42	Functional ≤ 10μM
Z80186-1-O	K562 (Erythroleukemia Cells) (cluster #1 Of 11), Other	Other	750	0.45	Functional ≤ 10μM
Z80224-6-O	MCF7 (Breast Carcinoma Cells) (cluster #6 Of 14), Other	Other	8500	0.37	Functional ≤ 10μM
Z80244-1-O	MDA-MB-468 (Breast Adenocarcinoma) (cluster #1 Of 7), Other	Other	5000	0.39	Functional ≤ 10μM
Z80322-1-O	NCI-H358 (Lung Carcinama Cells) (cluster #1 Of 2), Other	Other	2500	0.41	Functional ≤ 10μM
Z80390-3-O	PC-3 (Prostate Carcinoma Cells) (cluster #3 Of 10), Other	Other	6500	0.38	Functional ≤ 10μM
Z80418-9-O	RAW264.7 (Monocytic-macrophage Leukemia Cells) (cluster #9 Of 9), Other	Other	760	0.45	Functional ≤ 10μM
Z80475-2-O	SK-BR-3 (Breast Adenocarcinoma) (cluster #2 Of 3), Other	Other	2100	0.42	Functional ≤ 10μM
Z80493-3-O	SK-OV-3 (Ovarian Carcinoma Cells) (cluster #3 Of 6), Other	Other	2500	0.41	Functional ≤ 10μM
Z80513-1-O	SQ20B (cluster #1 Of 1), Other	Other	3000	0.41	Functional ≤ 10μM
Z80514-1-O	St-4 (Stomach Carcinoma Cells) (cluster #1 Of 1), Other	Other	5200	0.39	Functional ≤ 10μM
Z80682-2-O	A549 (Lung Carcinoma Cells) (cluster #2 Of 11), Other	Other	868	0.45	Functional ≤ 10μM
Z80838-1-O	EOL1 (Eosinophilic Cells) (cluster #1 Of 1), Other	Other	1000	0.44	Functional ≤ 10μM
Z80857-1-O	Friend Leukemia Cell Line (cluster #1 Of 2), Other	Other	990	0.44	Functional ≤ 10μM
Z80874-3-O	CEM (T-cell Leukemia) (cluster #3 Of 7), Other	Other	1900	0.42	Functional ≤ 10μM
Z80877-1-O	NCI-H1299 (Non-small Cell Lung Carcinoma) (cluster #1 Of 2), Other	Other	7240	0.38	Functional ≤ 10μM
Z80896-1-O	NCI-H69 (Small Cell Lung Carcinoma Cells) (cluster #1 Of 1), Other	Other	2060	0.42	Functional ≤ 10μM
Z80928-3-O	HCT-116 (Colon Carcinoma Cells) (cluster #3 Of 9), Other	Other	900	0.45	Functional ≤ 10μM
Z81020-4-O	HepG2 (Hepatoblastoma Cells) (cluster #4 Of 8), Other	Other	9300	0.37	Functional ≤ 10μM
Z81024-2-O	NCI-H460 (Non-small Cell Lung Carcinoma) (cluster #2 Of 8), Other	Other	3448	0.40	Functional ≤ 10μM
Z81034-3-O	A2780 (Ovarian Carcinoma Cells) (cluster #3 Of 10), Other	Other	2600	0.41	Functional ≤ 10μM
Z81072-6-O	Jurkat (Acute Leukemic T-cells) (cluster #6 Of 10), Other	Other	2300	0.42	Functional ≤ 10μM
Z81170-3-O	LNCaP (Prostate Carcinoma) (cluster #3 Of 5), Other	Other	580	0.46	Functional ≤ 10μM
Z81184-5-O	LOX IMVI (Melanoma Cells) (cluster #5 Of 5), Other	Other	1300	0.43	Functional ≤ 10μM
Z81245-4-O	MDA-MB-435 (Breast Carcinoma Cells) (cluster #4 Of 6), Other	Other	1900	0.42	Functional ≤ 10μM
Z81247-6-O	HeLa (Cervical Adenocarcinoma Cells) (cluster #6 Of 9), Other	Other	460	0.47	Functional ≤ 10μM
Z81252-6-O	MDA-MB-231 (Breast Adenocarcinoma Cells) (cluster #6 Of 11), Other	Other	2200	0.42	Functional ≤ 10μM
Z81280-3-O	NCI-H226 (Non-small Cell Lung Carcinoma Cells) (cluster #3 Of 3), Other	Other	3480	0.40	Functional ≤ 10μM
Z81281-4-O	NCI-H23 (Non-small Cell Lung Carcinoma Cells) (cluster #4 Of 5), Other	Other	383	0.47	Functional ≤ 10μM
Z81283-1-O	NCI-H522 (Non-small Cell Lung Carcinoma Cells) (cluster #1 Of 2), Other	Other	832	0.45	Functional ≤ 10μM
Z81331-1-O	SW-620 (Colon Adenocarcinoma Cells) (cluster #1 Of 6), Other	Other	600	0.46	Functional ≤ 10μM
Z81335-2-O	HCT-15 (Colon Adenocarcinoma Cells) (cluster #2 Of 5), Other	Other	3900	0.40	Functional ≤ 10μM
Z80957-2-O	HMEC (Microvascular Endothelial Cells) (cluster #2 Of 2), Other	Other	1300	0.43	ADME/T ≤ 10μM

ChEMBL Target Annotations
Uniprot	Swissprot	Description	Affinity (nM)	LE (kcal/mol/atom)	Type
Q9XYC7_PLAFA	Q9XYC7	Histone Deacetylase, Plafa	130	0.51	Binding ≤ 1μM
Q7K6A1_PLAF7	Q7K6A1	Histone Deacetylase, Plaf7	100	0.52	Binding ≤ 1μM
HDAC1_MOUSE	O09106	Histone Deacetylase 1, Mouse	112	0.51	Binding ≤ 1μM
HDAC1_RAT	Q4QQW4	Histone Deacetylase 1, Rat	165	0.50	Binding ≤ 1μM
HDAC1_HUMAN	Q13547	Histone Deacetylase 1, Human	1.3	0.65	Binding ≤ 1μM
HDA10_HUMAN	Q969S8	Histone Deacetylase 10, Human	10	0.59	Binding ≤ 1μM
HDA11_HUMAN	Q96DB2	Histone Deacetylase 11, Human	10	0.59	Binding ≤ 1μM
HDAC2_HUMAN	Q92769	Histone Deacetylase 2, Human	1.6	0.65	Binding ≤ 1μM
B1WBY8_RAT	B1WBY8	Histone Deacetylase 2, Rat	165	0.50	Binding ≤ 1μM
HDAC3_HUMAN	O15379	Histone Deacetylase 3, Human	10	0.59	Binding ≤ 1μM
HDAC3_RAT	Q6P6W3	Histone Deacetylase 3, Rat	165	0.50	Binding ≤ 1μM
HDAC4_HUMAN	P56524	Histone Deacetylase 4, Human	10	0.59	Binding ≤ 1μM
HDAC4_RAT	Q99P99	Histone Deacetylase 4, Rat	165	0.50	Binding ≤ 1μM
HDAC5_HUMAN	Q9UQL6	Histone Deacetylase 5, Human	10	0.59	Binding ≤ 1μM
Q5RJZ2_RAT	Q5RJZ2	Histone Deacetylase 5, Rat	165	0.50	Binding ≤ 1μM
HDAC6_HUMAN	Q9UBN7	Histone Deacetylase 6, Human	1	0.66	Binding ≤ 1μM
Q99P97_RAT	Q99P97	Histone Deacetylase 6, Rat	165	0.50	Binding ≤ 1μM
HDAC7_HUMAN	Q8WUI4	Histone Deacetylase 7, Human	10	0.59	Binding ≤ 1μM
HDAC7_RAT	Q99P96	Histone Deacetylase 7, Rat	165	0.50	Binding ≤ 1μM
HDAC8_HUMAN	Q9BY41	Histone Deacetylase 8, Human	10	0.59	Binding ≤ 1μM
HDAC9_HUMAN	Q9UKV0	Histone Deacetylase 9, Human	10	0.59	Binding ≤ 1μM
Q9ZTP8_MAIZE	Q9ZTP8	Histone Deacetylase HD1B, Maize	28	0.56	Binding ≤ 1μM
Q94F81_MAIZE	Q94F81	Histone Deacetylase HD2, Maize	1000	0.44	Binding ≤ 1μM
HDAH_ALCSD	Q70I53	Histone Deacetylase-like Amidohydrolase, Alcsd	1000	0.44	Binding ≤ 1μM
NCOR2_HUMAN	Q9Y618	Nuclear Receptor Corepressor 2, Human	18.8	0.57	Binding ≤ 1μM
Q9XYC7_PLAFA	Q9XYC7	Histone Deacetylase, Plafa	130	0.51	Binding ≤ 10μM
Q7K6A1_PLAF7	Q7K6A1	Histone Deacetylase, Plaf7	100	0.52	Binding ≤ 10μM
HDAC1_RAT	Q4QQW4	Histone Deacetylase 1, Rat	165	0.50	Binding ≤ 10μM
HDAC1_HUMAN	Q13547	Histone Deacetylase 1, Human	1.3	0.65	Binding ≤ 10μM
HDAC1_MOUSE	O09106	Histone Deacetylase 1, Mouse	112	0.51	Binding ≤ 10μM
HDA10_HUMAN	Q969S8	Histone Deacetylase 10, Human	10	0.59	Binding ≤ 10μM
HDA11_HUMAN	Q96DB2	Histone Deacetylase 11, Human	10	0.59	Binding ≤ 10μM
HDAC2_HUMAN	Q92769	Histone Deacetylase 2, Human	1.6	0.65	Binding ≤ 10μM
B1WBY8_RAT	B1WBY8	Histone Deacetylase 2, Rat	165	0.50	Binding ≤ 10μM
HDAC3_HUMAN	O15379	Histone Deacetylase 3, Human	10	0.59	Binding ≤ 10μM
HDAC3_RAT	Q6P6W3	Histone Deacetylase 3, Rat	165	0.50	Binding ≤ 10μM
HDAC4_RAT	Q99P99	Histone Deacetylase 4, Rat	165	0.50	Binding ≤ 10μM
HDAC4_HUMAN	P56524	Histone Deacetylase 4, Human	10	0.59	Binding ≤ 10μM
Q5RJZ2_RAT	Q5RJZ2	Histone Deacetylase 5, Rat	165	0.50	Binding ≤ 10μM
HDAC5_HUMAN	Q9UQL6	Histone Deacetylase 5, Human	10	0.59	Binding ≤ 10μM
Q99P97_RAT	Q99P97	Histone Deacetylase 6, Rat	165	0.50	Binding ≤ 10μM
HDAC6_HUMAN	Q9UBN7	Histone Deacetylase 6, Human	1	0.66	Binding ≤ 10μM
HDAC7_RAT	Q99P96	Histone Deacetylase 7, Rat	165	0.50	Binding ≤ 10μM
HDAC7_HUMAN	Q8WUI4	Histone Deacetylase 7, Human	10	0.59	Binding ≤ 10μM
HDAC8_HUMAN	Q9BY41	Histone Deacetylase 8, Human	10	0.59	Binding ≤ 10μM
HDAC9_HUMAN	Q9UKV0	Histone Deacetylase 9, Human	10	0.59	Binding ≤ 10μM
Q9ZTP8_MAIZE	Q9ZTP8	Histone Deacetylase HD1B, Maize	28	0.56	Binding ≤ 10μM
Q94F81_MAIZE	Q94F81	Histone Deacetylase HD2, Maize	1000	0.44	Binding ≤ 10μM
HDAH_ALCSD	Q70I53	Histone Deacetylase-like Amidohydrolase, Alcsd	1000	0.44	Binding ≤ 10μM
NCOR2_HUMAN	Q9Y618	Nuclear Receptor Corepressor 2, Human	18.8	0.57	Binding ≤ 10μM
Z81034	Z81034	A2780 (Ovarian Carcinoma Cells)	1620	0.43	Functional ≤ 10μM
Z103205	Z103205	A431	4200	0.40	Functional ≤ 10μM
Z80682	Z80682	A549 (Lung Carcinoma Cells)	1800	0.42	Functional ≤ 10μM
Z80054	Z80054	Caco-2 (Colon Adenocarcinoma Cells)	8100	0.38	Functional ≤ 10μM
Z80064	Z80064	CCRF-CEM (T-cell Leukemia)	800	0.45	Functional ≤ 10μM
Z80874	Z80874	CEM (T-cell Leukemia)	1900	0.42	Functional ≤ 10μM
Z80125	Z80125	DU-145 (Prostate Carcinoma)	1600	0.43	Functional ≤ 10μM
Z80838	Z80838	EOL1 (Eosinophilic Cells)	1000	0.44	Functional ≤ 10μM
Z80857	Z80857	Friend Leukemia Cell Line	990	0.44	Functional ≤ 10μM
Z80928	Z80928	HCT-116 (Colon Carcinoma Cells)	1000	0.44	Functional ≤ 10μM
Z81335	Z81335	HCT-15 (Colon Adenocarcinoma Cells)	3900	0.40	Functional ≤ 10μM
Z81247	Z81247	HeLa (Cervical Adenocarcinoma Cells)	1500	0.43	Functional ≤ 10μM
Z81020	Z81020	HepG2 (Hepatoblastoma Cells)	0.6	0.68	Functional ≤ 10μM
HDAC1_HUMAN	Q13547	Histone Deacetylase 1, Human	125	0.51	Functional ≤ 10μM
HDA10_HUMAN	Q969S8	Histone Deacetylase 10, Human	7200	0.38	Functional ≤ 10μM
HDA11_HUMAN	Q96DB2	Histone Deacetylase 11, Human	7200	0.38	Functional ≤ 10μM
HDAC2_HUMAN	Q92769	Histone Deacetylase 2, Human	28	0.56	Functional ≤ 10μM
HDAC3_HUMAN	O15379	Histone Deacetylase 3, Human	28	0.56	Functional ≤ 10μM
HDAC4_HUMAN	P56524	Histone Deacetylase 4, Human	178	0.50	Functional ≤ 10μM
HDAC5_HUMAN	Q9UQL6	Histone Deacetylase 5, Human	178	0.50	Functional ≤ 10μM
HDAC6_HUMAN	Q9UBN7	Histone Deacetylase 6, Human	7200	0.38	Functional ≤ 10μM
HDAC7_HUMAN	Q8WUI4	Histone Deacetylase 7, Human	178	0.50	Functional ≤ 10μM
HDAC8_HUMAN	Q9BY41	Histone Deacetylase 8, Human	28	0.56	Functional ≤ 10μM
HDAC9_HUMAN	Q9UKV0	Histone Deacetylase 9, Human	178	0.50	Functional ≤ 10μM
Q94F81_MAIZE	Q94F81	Histone Deacetylase HD2, Maize	50	0.54	Functional ≤ 10μM
Z80156	Z80156	HL-60 (Promyeloblast Leukemia Cells)	1200	0.44	Functional ≤ 10μM
Z80164	Z80164	HT-1080 (Fibrosarcoma Cells)	2.4	0.64	Functional ≤ 10μM
Z80166	Z80166	HT-29 (Colon Adenocarcinoma Cells)	2000	0.42	Functional ≤ 10μM
Z81072	Z81072	Jurkat (Acute Leukemic T-cells)	2300	0.42	Functional ≤ 10μM
Z80186	Z80186	K562 (Erythroleukemia Cells)	2200	0.42	Functional ≤ 10μM
Z81170	Z81170	LNCaP (Prostate Carcinoma)	1000	0.44	Functional ≤ 10μM
Z81184	Z81184	LOX IMVI (Melanoma Cells)	1300	0.43	Functional ≤ 10μM
Z80224	Z80224	MCF7 (Breast Carcinoma Cells)	1150	0.44	Functional ≤ 10μM
Z81252	Z81252	MDA-MB-231 (Breast Adenocarcinoma Cells)	1180	0.44	Functional ≤ 10μM
Z81245	Z81245	MDA-MB-435 (Breast Carcinoma Cells)	1900	0.42	Functional ≤ 10μM
Z80244	Z80244	MDA-MB-468 (Breast Adenocarcinoma)	1300	0.43	Functional ≤ 10μM
Z80877	Z80877	NCI-H1299 (Non-small Cell Lung Carcinoma)	550	0.46	Functional ≤ 10μM
Z103348	Z103348	NCI-H2122	7500	0.38	Functional ≤ 10μM
Z81280	Z81280	NCI-H226 (Non-small Cell Lung Carcinoma Cells)	2600	0.41	Functional ≤ 10μM
Z81281	Z81281	NCI-H23 (Non-small Cell Lung Carcinoma Cells)	383	0.47	Functional ≤ 10μM
Z80322	Z80322	NCI-H358 (Lung Carcinama Cells)	2500	0.41	Functional ≤ 10μM
Z81024	Z81024	NCI-H460 (Non-small Cell Lung Carcinoma)	3448	0.40	Functional ≤ 10μM
Z81283	Z81283	NCI-H522 (Non-small Cell Lung Carcinoma Cells)	832	0.45	Functional ≤ 10μM
Z80896	Z80896	NCI-H69 (Small Cell Lung Carcinoma Cells)	2060	0.42	Functional ≤ 10μM
Z80390	Z80390	PC-3 (Prostate Carcinoma Cells)	1210	0.44	Functional ≤ 10μM
Z50425	Z50425	Plasmodium Falciparum	109.7	0.51	Functional ≤ 10μM
Z50136	Z50136	Plasmodium Falciparum (isolate FcB1 / Columbia)	820	0.45	Functional ≤ 10μM
Z102015	Z102015	Plasmodium Vivax	147	0.50	Functional ≤ 10μM
Z80418	Z80418	RAW264.7 (Monocytic-macrophage Leukemia Cells)	1880	0.42	Functional ≤ 10μM
Z80475	Z80475	SK-BR-3 (Breast Adenocarcinoma)	1190	0.44	Functional ≤ 10μM
Z80493	Z80493	SK-OV-3 (Ovarian Carcinoma Cells)	2200	0.42	Functional ≤ 10μM
Z80513	Z80513	SQ20B	3000	0.41	Functional ≤ 10μM
Z80514	Z80514	St-4 (Stomach Carcinoma Cells)	5200	0.39	Functional ≤ 10μM
Z81331	Z81331	SW-620 (Colon Adenocarcinoma Cells)	600	0.46	Functional ≤ 10μM
Z80957	Z80957	HMEC (Microvascular Endothelial Cells)	1300	0.43	ADME/T ≤ 10μM

Reactome Annotations from Targets (via Uniprot)

Description	Species
BMAL1:CLOCK,NPAS2 activates circadian gene expression	Homo sapiens (HDAC3_HUMAN)
Circadian Clock	Homo sapiens (HDAC3_HUMAN)
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	Rattus norvegicus (Q5RJZ2_RAT) Homo sapiens (HDAC3_HUMAN) Mus musculus (HDAC1_MOUSE)
Constitutive Signaling by NOTCH1 PEST Domain Mutants	Homo sapiens (HDAC3_HUMAN) Mus musculus (HDAC1_MOUSE) Rattus norvegicus (Q5RJZ2_RAT)
deactivation of the beta-catenin transactivating complex	Mus musculus (HDAC1_MOUSE) Homo sapiens (HDAC1_HUMAN)
Downregulation of SMAD2/3:SMAD4 transcriptional activity	Mus musculus (HDAC1_MOUSE) Homo sapiens (HDAC1_HUMAN)
Factors involved in megakaryocyte development and platelet production	Mus musculus (HDAC1_MOUSE) Rattus norvegicus (B1WBY8_RAT) Homo sapiens (HDAC1_HUMAN)
formation of the beta-catenin:TCF transactivating complex	Homo sapiens (HDAC1_HUMAN) Mus musculus (HDAC1_MOUSE)
G0 and Early G1	Homo sapiens (HDAC1_HUMAN) Mus musculus (HDAC1_MOUSE)
HDACs deacetylate histones	Homo sapiens (HDAC3_HUMAN) Rattus norvegicus (B1WBY8_RAT) Mus musculus (HDAC1_MOUSE)
HSF1 activation	Homo sapiens (HDAC6_HUMAN)
NoRC negatively regulates rRNA expression	Homo sapiens (HDAC1_HUMAN) Mus musculus (HDAC1_MOUSE) Rattus norvegicus (B1WBY8_RAT) Mus musculus (HDAC1_MOUSE)
NOTCH1 Intracellular Domain Regulates Transcription	Mus musculus (HDAC1_MOUSE) Rattus norvegicus (Q5RJZ2_RAT) Homo sapiens (HDAC3_HUMAN)
p75NTR negatively regulates cell cycle via SC1	Homo sapiens (HDAC3_HUMAN) Rattus norvegicus (B1WBY8_RAT) Mus musculus (HDAC1_MOUSE)
PPARA activates gene expression	Homo sapiens (HDAC3_HUMAN)
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alp	Homo sapiens (HDAC3_HUMAN)
repression of WNT target genes	Homo sapiens (HDAC1_HUMAN) Mus musculus (HDAC1_MOUSE)
REV-ERBA represses gene expression	Homo sapiens (HDAC3_HUMAN)
RNA Polymerase I Transcription Initiation	Mus musculus (HDAC1_MOUSE) Rattus norvegicus (B1WBY8_RAT) Homo sapiens (HDAC1_HUMAN)
RORA activates circadian gene expression	Homo sapiens (HDAC3_HUMAN)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	Homo sapiens (HDAC1_HUMAN)
Transcriptional activation of mitochondrial biogenesis	Homo sapiens (HDAC3_HUMAN)
Transcriptional regulation of white adipocyte differentiation	Homo sapiens (HDAC3_HUMAN)

Analogs ( Draw Identity 99% 90% 80% 70% )

23636369

Synonyms (82)
Vendors (27)
Annotations (25)
Representations (1)
Notes (7)
Targets (105)
Clustered (75)
Reactome (23)
Rings (0)
Analogs (1)