UCSF

ZINC00016827

Substance Information

In ZINC since Heavy atoms Benign functionality
September 26th, 2005 15 Yes

Other Names:

crine

1,2,3,4-tetrahydro-9-acridinamine

1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE (SEE ALSO 1684-40-8)

1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE (SEE ALSO 1684-40-8); 1,2,3,4-Tetrahydro-9-acridinamine; 1,2,3,4-Tetrahydroaminoacridine; 5-Amino-6,7,8,9-tetrahydroacridine (European); 9-Acridinamine, 1,2,3,4-tetrahydro-; 9-Amino-1,2,3,4-tetrahydroacridine; Acridine, 1

1,2,3,4-Tetrahydro-9-acridineamine

1,2,3,4-Tetrahydro-acridin-9-ylamine

1,2,3,4-tetrahydroacridin-9-amine dihydrochloride

1,2,3,4-tetrahydroacridin-9-amine hydrochloride

1,2,3,4-Tetrahydroaminoacridine

1684-40-8 (hydrochloride)

1684-40-8; Cognex (TN); D02068; Tacrine hydrochloride (USP)

1684-40-8; Prestwick_733; Tacrine hydrochloride hydrate

1mx1

2aow

2aox

321-64-2

321-64-2; C01453; Tacrine

321-64-2; D08555; Tacrinal (TN); Tacrine (INN)

5-Amino-6,7,8,9-tetrahydroacridine (European)

502

9-Acridinamine, 1,2,3,4-tetrahydro-

9-Acridinamine, 1,2,3,4-tetrahydro- (9CI)

9-Acridinamine,1,2,3,4-tetrahydro-

9-amino-1,2,3,4-tetrahydroacridine

9-Amino-1,2,3,4-tetrahydroacridine HCl hydrate

9-Amino-1,2,3,4-Tetrahydroacridine Hydrate Hydrochloride Hydrate

9-Amino-1,2,3,4-tetrahydroacridine hydrochloride

9-Amino-1,2,3,4-tetrahydroacridine hydrochloride hydrate

9-AMINO-1,2,3,4-TETRAHYDROACRIDINE HYDROCHLORIDE; CPD000059105; SAM001247002

9-AMINO-1,2,3,4-TETRAHYDROACRIDINE HYDROCHLORIDE; CPD000059105; SAM001247002; Tacrine hydrochloride

9-Amino-1,2,3,4-tetrahydroacridine hydrochloridehydrate

9-AMINOTETRAHYDROACRIDINE

AB00053524

AC1L1CK0

AC1Q51C5

Acridine, 1,2,3,4-tetrahydro-9-amino-

AKOS000277493

BAS 00232275

BBL001044

BIDD:GT0090

BPBio1_000371

BRD-K81473089-003-03-0

BRD-K81473089-003-04-8

BRN 0147610

BSPBio_000337

BSPBio_003298

C01453

C13H14N2

CHEBI:45978; CHEBI:9389

CHEBI:45980

CHEMBL95

CI-970

CID1935

Cognex

CPD-10887

CPD-10887; Cognex; Romotal; Tenakrin; Tetrahydroaminacrine; Tetrahydroaminoacridine; Tetrahydroaminocrin; Tetrahydroaminocrine; tacrine

CPD000059105; 9-AMINO-1,2,3,4-TETRAHYDROACRIDINE HYDROCHLORIDE

CS 12602

D08555

DAP000558

DB00382

DivK1c_000936

EINECS 206-291-2

EU-0010966

FDA)

FT-0083001

HMS2089F19

IDI1_000936

INN)

INN); Tacrine HCl (FDA

INN); Tacrine HCl (USAN

KBio1_000936

KBio2_000896

KBio2_003464

KBio2_006032

KBio3_002518

KBioGR_001337

KBioSS_000896

LS-1191

LS-190438

MFCD00012657

MFCD00046923

MFCD00150067

MLS000758202

MolPort-000-881-472

N/A

NA

NCGC00015054-01

NCGC00015054-07

NCGC00024908-01

NCGC00024908-03

NCGC00024908-04

NCGC00024908-05

nchembio.188-comp31

nchembio.2007.55-comp2

NCIOpen2_003667

NINDS_000936

Oprea1_008681

OROS-tacrine

PDSP1_000330

PDSP2_000328

Prestwick0_000329

Prestwick1_000329

Prestwick2_000329

Prestwick3_000329

Romotal

SPBio_001823

SPBio_002258

Spectrum2_001812

Spectrum3_001709

Spectrum4_000819

Spectrum5_001402

Spectrum_000416

ST083243

STK101308

Tacrina

Tacrina [INN-Spanish]

Tacrinal

Tacrinal (TN)

Tacrine

Tacrine (BAN

Tacrine (hydrochloride)

Tacrine (INN)

tacrine hydrochlorid

Tacrine Hydrochloride

Tacrine Hydrochloride (FDA

Tacrine [INN:BAN]

Tacrinum

Tacrinum [INN-Latin]

Tenakrin

Tetrahydroaminacrine

Tetrahydroaminacrine;Tetrahydroaminoacridine;Tetrahydroaminocrin;Tetrahydroaminocrine;THA

Tetrahydroaminoacridine

Tetrahydroaminocrin

Tetrahydroaminocrine

THA

THA.HCl

Tocris-0965

UNII-4VX7YNB537

USAN

USP

USP)

USP); Tacrine (BAN

ZINC19014866

Download: MOL2 SDF SMILES Flexibase

Annotations

Vendors

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.05 5.64 -23.7 3 2 1 40 199.277 0

Vendor Notes

Note Type Comments Provided By
Molecular_Solubility 3.743 Bitter DB
ALOGPS_SOLUBILITY 1.36e-01 g/l DrugBank-approved
mp 104.5 - 106 MolMall (formerly Molecular Diversity Preservation International)
MP 280 - 284 Enamine Building Blocks
MP 280...284 Enamine Building Blocks
purity 9.500000000000000e+001 Enamine Building Blocks Enamine Building Blocks
Purity 95% Fluorochem
Purity 97% Fluorochem
therap anticholinesterase, cognitive adjuvant, K channel blocker MicroSource Spectrum
Therapy Cholinesterase inhibitor; reported to be useful SMDC Iconix
Patent Database Links EP1088550; EP1118322; EP1457490; EP1514542; EP1576985; EP1779867; EP1844769; EP1857817; EP1867642; EP1918286; EP1938811; US2003026850; US2003166721; US2004142904; US2004254182; US2005009870; US2005014786; US2005026946; US2005080087; US2005187267; US200525 ChEBI
PUBCHEM_SUBSTANCE_COMMENT NCC_SAMPLE_SUPPLIER : Tocris Cookson Ltd.; NCC_SUPPLIER_STRUCTURE_ID : 101925; 1 hydrogen chloride NIH Clinical Collection via PubChem
Target Others Selleck Chemicals
PUBCHEM_SUBSTANCE_COMMENT SAMPLE_SUPPLIER: Tocris Bioscience; SUPPLIER_STRUCTURE_ID: 101925; SALT: 1 hydrogen chloride NIH Clinical Collection via PubChem

Activity (Go SEA)

Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
ACES-2-E Acetylcholinesterase (cluster #2 Of 12), Eukaryotic Eukaryotes 88 0.66 Binding ≤ 10μM
ACHE-1-E Acetylcholine Receptor Protein Epsilon Chain (cluster #1 Of 1), Eukaryotic Eukaryotes 44 0.69 Binding ≤ 10μM
ACM1-3-E Muscarinic Acetylcholine Receptor M1 (cluster #3 Of 5), Eukaryotic Eukaryotes 2000 0.53 Binding ≤ 10μM
ACM2-1-E Muscarinic Acetylcholine Receptor M2 (cluster #1 Of 6), Eukaryotic Eukaryotes 220 0.62 Binding ≤ 10μM
CHLE-2-E Butyrylcholinesterase (cluster #2 Of 7), Eukaryotic Eukaryotes 7 0.76 Binding ≤ 10μM
CLAT-2-E Choline Acetylase (cluster #2 Of 2), Eukaryotic Eukaryotes 0 0.00 Binding ≤ 10μM
HNMT-1-E Histamine N-methyltransferase (cluster #1 Of 1), Eukaryotic Eukaryotes 110 0.65 Binding ≤ 10μM
Q9JKC1-1-E Butyrylcholinesterase (cluster #1 Of 1), Eukaryotic Eukaryotes 92 0.66 Binding ≤ 10μM
Q9N1N9-1-E Butyrylcholinesterase (cluster #1 Of 2), Eukaryotic Eukaryotes 7 0.76 Binding ≤ 10μM
ACM2-1-E Muscarinic Acetylcholine Receptor M2 (cluster #1 Of 3), Eukaryotic Eukaryotes 5800 0.49 Functional ≤ 10μM
Q9WTR4-2-E Norepinephrine Transporter (cluster #2 Of 2), Eukaryotic Eukaryotes 7900 0.48 Functional ≤ 10μM
SC6A4-1-E Serotonin Transporter (cluster #1 Of 1), Eukaryotic Eukaryotes 7600 0.48 Functional ≤ 10μM
CP1A2-1-E Cytochrome P450 1A2 (cluster #1 Of 3), Eukaryotic Eukaryotes 1940 0.53 ADME/T ≤ 10μM
Z104298-1-O Glutamate NMDA Receptor; GRIN1/GRIN2A (cluster #1 Of 2), Other Other 4900 0.50 Binding ≤ 10μM
Z104303-4-O Muscarinic Acetylcholine Receptor (cluster #4 Of 7), Other Other 7300 0.48 Binding ≤ 10μM
Z50425-3-O Plasmodium Falciparum (cluster #3 Of 22), Other Other 5012 0.49 Functional ≤ 10μM
Z50594-1-O Mus Musculus (cluster #1 Of 9), Other Other 5800 0.49 Functional ≤ 10μM
ChEMBL Target Annotations
Uniprot Swissprot Description Affinity (nM) LE (kcal/mol/atom) Type
ACHE_HUMAN Q04844 Acetylcholine Receptor Protein Epsilon Chain, Human 44 0.69 Binding ≤ 1μM
ACES_RAT P37136 Acetylcholinesterase, Rat 223 0.62 Binding ≤ 1μM
ACES_BOVIN P23795 Acetylcholinesterase, Bovin 130 0.64 Binding ≤ 1μM
ACES_HUMAN P22303 Acetylcholinesterase, Human 136 0.64 Binding ≤ 1μM
ACES_MOUSE P21836 Acetylcholinesterase, Mouse 143 0.64 Binding ≤ 1μM
ACES_TORCA P04058 Acetylcholinesterase, Torca 157 0.64 Binding ≤ 1μM
ACES_ELEEL O42275 Acetylcholinesterase, Eleel 193 0.63 Binding ≤ 1μM
Q9N1N9_HORSE Q9N1N9 Butyrylcholinesterase, Horse 19 0.72 Binding ≤ 1μM
CHLE_HUMAN P06276 Butyrylcholinesterase, Human 43.9 0.69 Binding ≤ 1μM
Q9JKC1_RAT Q9JKC1 Butyrylcholinesterase, Rat 92 0.66 Binding ≤ 1μM
CLAT_RAT P32738 Choline Acetylase, Rat 0.151 0.92 Binding ≤ 1μM
CHLE_HORSE P81908 Cholinesterase, Horse 27.1 0.71 Binding ≤ 1μM
HNMT_RAT Q01984 Histamine N-methyltransferase, Rat 110 0.65 Binding ≤ 1μM
ACM2_MOUSE Q9ERZ4 Muscarinic Acetylcholine Receptor M2, Mouse 220 0.62 Binding ≤ 1μM
ACHE_HUMAN Q04844 Acetylcholine Receptor Protein Epsilon Chain, Human 44 0.69 Binding ≤ 10μM
ACES_BOVIN P23795 Acetylcholinesterase, Bovin 130 0.64 Binding ≤ 10μM
ACES_HUMAN P22303 Acetylcholinesterase, Human 1026 0.56 Binding ≤ 10μM
ACES_MOUSE P21836 Acetylcholinesterase, Mouse 143 0.64 Binding ≤ 10μM
ACES_TORCA P04058 Acetylcholinesterase, Torca 157 0.64 Binding ≤ 10μM
ACES_ELEEL O42275 Acetylcholinesterase, Eleel 193 0.63 Binding ≤ 10μM
ACES_RAT P37136 Acetylcholinesterase, Rat 223 0.62 Binding ≤ 10μM
Q9N1N9_HORSE Q9N1N9 Butyrylcholinesterase, Horse 19 0.72 Binding ≤ 10μM
Q9JKC1_RAT Q9JKC1 Butyrylcholinesterase, Rat 92 0.66 Binding ≤ 10μM
CHLE_HUMAN P06276 Butyrylcholinesterase, Human 43.9 0.69 Binding ≤ 10μM
CLAT_RAT P32738 Choline Acetylase, Rat 0.151 0.92 Binding ≤ 10μM
CHLE_HORSE P81908 Cholinesterase, Horse 27.1 0.71 Binding ≤ 10μM
Z104298 Z104298 Glutamate NMDA Receptor; GRIN1/GRIN2A 4900 0.50 Binding ≤ 10μM
HNMT_RAT Q01984 Histamine N-methyltransferase, Rat 110 0.65 Binding ≤ 10μM
Z104303 Z104303 Muscarinic Acetylcholine Receptor 5900 0.49 Binding ≤ 10μM
ACM1_MOUSE P12657 Muscarinic Acetylcholine Receptor M1, Mouse 2000 0.53 Binding ≤ 10μM
ACM2_RAT P10980 Muscarinic Acetylcholine Receptor M2, Rat 2100 0.53 Binding ≤ 10μM
ACM2_MOUSE Q9ERZ4 Muscarinic Acetylcholine Receptor M2, Mouse 2100 0.53 Binding ≤ 10μM
ACM2_PIG P06199 Muscarinic Acetylcholine Receptor M2, Pig 6300 0.49 Binding ≤ 10μM
Z50594 Z50594 Mus Musculus 220 0.62 Functional ≤ 10μM
ACM2_HUMAN P08172 Muscarinic Acetylcholine Receptor M2, Human 5800 0.49 Functional ≤ 10μM
Q9WTR4_RAT Q9WTR4 Norepinephrine Transporter, Rat 7900 0.48 Functional ≤ 10μM
Z50425 Z50425 Plasmodium Falciparum 10000 0.47 Functional ≤ 10μM
SC6A4_RAT P31652 Serotonin Transporter, Rat 7600 0.48 Functional ≤ 10μM
CP1A2_HUMAN P05177 Cytochrome P450 1A2, Human 1940 0.53 ADME/T ≤ 10μM

Reactome Annotations from Targets (via Uniprot)

Description Species
Aflatoxin activation and detoxification
Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2
G alpha (i) signalling events
G alpha (q) signalling events
Highly sodium permeable acetylcholine nicotinic receptors
Methylation
Muscarinic acetylcholine receptors
Neurotransmitter Clearance In The Synaptic Cleft
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)
Synthesis of PC
Synthesis, secretion, and deacylation of Ghrelin

Analogs ( Draw Identity 99% 90% 80% 70% )