UCSF

ZINC21982951

Draw Identity 99% 90% 80% 70%

Substance Information

In ZINC since Heavy atoms Benign functionality
December 11th, 2008 33 Yes

Popular Name: Dasatinib Dasatinib

Find On: PubMed — Wikipedia — Google

CAS Numbers: 302962-49-8 , 302962-49-8; 863127-77-9 , 863127-77-9 , [302962-49-8] , [863127-77-9]

Other Names:

(18F)-N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide

tinib

1N1

2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide

302962-49-8

5-Thiazolecarboxamide, N-(2-chloro-6-methylphenyl)-2-((6-(4-(2-hydroxyethyl)-1-piperazinyl)-2-methyl-4-pyrimidinyl)amino)-

5-Thiazolecarboxamide, N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-

863127-77-9; D06414; Dasatinib (USAN); Dasatinib hydrate (JAN); Sprycel (TN)

AC1MI3ET

AC1Q2P0C

AmbotzLS-1203

BCB03_000715

BMS 354825

BMS 354825-03; BMS 35482503; N-(2-chloro-6-methylphenyl)-2-((6-(4-(2- hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide hydrate; dasatinib; dasatinib hydrate; dasatinib.H2O

BMS-354825

BMS-354825, Sprycel, BMS354825, Dasatinib

BMS-354825; anh. dasatinib; anhydrous dasatinib; dasatinib (anh.)

BMS-354825; BMS-354825-03

BMS354825

C488369

CHEBI:38943; CHEBI:49372

CHEBI:49375

CHEMBL1421

CID3062316

D03658

DAP000004

Dasatinib (anhydrous)

Dasatinib (BMS-354825)

Dasatinib (FDA

Dasatinib (USAN

Dasatinib (USAN)

Dasatinib anhydrous

Dasatinib monohydrate

Dasatinib [USAN]

Dasatinib(anhydrous)

Dasatinib(monohydrate)

Dasatinib, BMS 354825

dasatinib; dasatinibum

dasatinibum

DB01254

EC-000.2122

EN002710

FDA)

FT-0084503

I14-1972

INN

Kinome_3650

LS-186641

LS-187028

LS-187773

MFCD08704581

MFCD11046566

MolPort-003-846-143

N-(2-chloro-6-methylphenyl)-2-((6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide

N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide

N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE

N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide, monohydrate

N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl]amino]-1,3-thiazole-5-

N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl]amino]-1,3-thiazole-5-carboxamide

NA

NCGC00181129-01

nchembio.117-comp11

nchembio.162-comp4

nchembio.332-comp1

NSC-732517

NSC732517

QA-3341

S1021_Selleck

Sprycel

SPRYCEL (TN)

Spyrcel

ST-7591

UNII-X78UG0A0RN

USAN)

Download: MOL2 SDF SMILES Flexibase

Annotations

Vendors

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.13 7.33 -37.83 4 9 1 108 489.025 7 ↓
Mid Mid (pH 6-8) 3.13 7.4 -39.94 4 9 1 108 489.025 7 ↓
Mid Mid (pH 6-8) 3.13 7.04 -18.14 3 9 0 107 488.017 7 ↓
Mid Mid (pH 6-8) 3.13 9.7 -105.45 5 9 2 109 490.033 7 ↓

Vendor Notes

Note Type Comments Provided By
ALOGPS_SOLUBILITY 1.28e-02 g/l DrugBank-approved
Purity 95+% Matrix Scientific
UniProt Database Links ACK1_HUMAN; CSF1R_HUMAN; CSF1R_MOUSE; LYN_HUMAN; LYN_MOUSE ChEBI
Therapy antineoplastic SMDC Pharmakon
Patent Database Links EP1977765; US2004073026; US2007179125; US2007249031; US2007259869; WO2007096393; WO2007096395; WO2007109178; WO2007113268; WO2007113269; WO2007113270; WO2007116025; WO2007120726; WO2007124498; WO2007128827; WO2007128829; WO2008115973; WO2008128009; WO2008 ChEBI
Warnings IRRITANT Matrix Scientific
Target Src, Bcr-Abl, c-Kit Selleck Chemicals

Activity (Go SEA)

Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
ABL1-1-E Tyrosine-protein Kinase ABL (cluster #1 Of 1), Eukaryotic Eukaryotes 590 0.26 Binding ≤ 10μM
ABL2-1-E Tyrosine-protein Kinase ABL2 (cluster #1 Of 1), Eukaryotic Eukaryotes 0 0.00 Binding ≤ 10μM
ACK1-1-E Tyrosine Kinase Non-receptor Protein 2 (cluster #1 Of 1), Eukaryotic Eukaryotes 6 0.35 Binding ≤ 10μM
ACV1B-1-E Activin Receptor Type-1B (cluster #1 Of 1), Eukaryotic Eukaryotes 330 0.27 Binding ≤ 10μM
ACVL1-1-E Serine/threonine-protein Kinase Receptor R3 (cluster #1 Of 1), Eukaryotic Eukaryotes 460 0.27 Binding ≤ 10μM
ACVR1-1-E Activin Receptor Type-1 (cluster #1 Of 1), Eukaryotic Eukaryotes 620 0.26 Binding ≤ 10μM
ADCK3-1-E Chaperone Activity Of Bc1 Complex-like, Mitochondrial (cluster #1 Of 1), Eukaryotic Eukaryotes 190 0.29 Binding ≤ 10μM
AURKB-1-E Serine/threonine-protein Kinase Aurora-B (cluster #1 Of 2), Eukaryotic Eukaryotes 6485 0.22 Binding ≤ 10μM
AVR2A-1-E Activin Receptor Type-2A (cluster #1 Of 1), Eukaryotic Eukaryotes 210 0.28 Binding ≤ 10μM
AVR2B-1-E Activin Receptor Type-2B (cluster #1 Of 1), Eukaryotic Eukaryotes 570 0.26 Binding ≤ 10μM
BCR-1-E Breakpoint Cluster Region Protein (cluster #1 Of 1), Eukaryotic Eukaryotes 1 0.38 Binding ≤ 10μM
BLK-1-E Tyrosine-protein Kinase BLK (cluster #1 Of 1), Eukaryotic Eukaryotes 0 0.00 Binding ≤ 10μM
BMX-1-E Tyrosine-protein Kinase BMX (cluster #1 Of 1), Eukaryotic Eukaryotes 1 0.38 Binding ≤ 10μM
BRAF-1-E Serine/threonine-protein Kinase B-raf (cluster #1 Of 1), Eukaryotic Eukaryotes 570 0.26 Binding ≤ 10μM
BTK-1-E Tyrosine-protein Kinase BTK (cluster #1 Of 1), Eukaryotic Eukaryotes 5 0.35 Binding ≤ 10μM
CSF1R-1-E Macrophage Colony-stimulating Factor 1 Receptor (cluster #1 Of 1), Eukaryotic Eukaryotes 7 0.35 Binding ≤ 10μM
CSK-1-E Tyrosine-protein Kinase CSK (cluster #1 Of 1), Eukaryotic Eukaryotes 1 0.38 Binding ≤ 10μM
DDR1-1-E Epithelial Discoidin Domain-containing Receptor 1 (cluster #1 Of 1), Eukaryotic Eukaryotes 1 0.38 Binding ≤ 10μM
DDR2-1-E Discoidin Domain-containing Receptor 2 (cluster #1 Of 1), Eukaryotic Eukaryotes 3 0.36 Binding ≤ 10μM
DMPK-1-E Myotonin-protein Kinase (cluster #1 Of 1), Eukaryotic Eukaryotes 1300 0.25 Binding ≤ 10μM
E2AK4-1-E Eukaryotic Translation Initiation Factor 2-alpha Kinase 4 (cluster #1 Of 1), Eukaryotic Eukaryotes 1600 0.25 Binding ≤ 10μM
EGFR-1-E Epidermal Growth Factor Receptor ErbB1 (cluster #1 Of 4), Eukaryotic Eukaryotes 79 0.30 Binding ≤ 10μM
EPHA1-1-E Ephrin Type-A Receptor 1 (cluster #1 Of 1), Eukaryotic Eukaryotes 4 0.36 Binding ≤ 10μM
EPHA2-1-E Ephrin Type-A Receptor 2 (cluster #1 Of 1), Eukaryotic Eukaryotes 137 0.29 Binding ≤ 10μM
EPHA3-1-E Ephrin Type-A Receptor 3 (cluster #1 Of 2), Eukaryotic Eukaryotes 0 0.00 Binding ≤ 10μM
EPHA4-1-E Ephrin Type-A Receptor 4 (cluster #1 Of 1), Eukaryotic Eukaryotes 1 0.38 Binding ≤ 10μM
EPHA5-1-E Ephrin Type-A Receptor 5 (cluster #1 Of 1), Eukaryotic Eukaryotes 0 0.00 Binding ≤ 10μM
EPHA8-1-E Ephrin Type-A Receptor 8 (cluster #1 Of 1), Eukaryotic Eukaryotes 0 0.00 Binding ≤ 10μM
EPHB1-1-E Ephrin Type-B Receptor 1 (cluster #1 Of 1), Eukaryotic Eukaryotes 0 0.00 Binding ≤ 10μM
EPHB2-1-E Ephrin Type-B Receptor 2 (cluster #1 Of 1), Eukaryotic Eukaryotes 4 0.36 Binding ≤ 10μM
EPHB3-1-E Ephrin Type-B Receptor 3 (cluster #1 Of 1), Eukaryotic Eukaryotes 7 0.35 Binding ≤ 10μM
EPHB4-1-E Ephrin Type-B Receptor 4 (cluster #1 Of 1), Eukaryotic Eukaryotes 1 0.38 Binding ≤ 10μM
ERBB2-2-E Receptor Protein-tyrosine Kinase ErbB-2 (cluster #2 Of 3), Eukaryotic Eukaryotes 710 0.26 Binding ≤ 10μM
FGFR1-1-E Fibroblast Growth Factor Receptor 1 (cluster #1 Of 1), Eukaryotic Eukaryotes 880 0.26 Binding ≤ 10μM
FGFR2-1-E Fibroblast Growth Factor Receptor 2 (cluster #1 Of 1), Eukaryotic Eukaryotes 1400 0.25 Binding ≤ 10μM
FGR-1-E Tyrosine-protein Kinase FGR (cluster #1 Of 2), Eukaryotic Eukaryotes 1 0.38 Binding ≤ 10μM
FLT3-1-E Tyrosine-protein Kinase Receptor FLT3 (cluster #1 Of 1), Eukaryotic Eukaryotes 8100 0.22 Binding ≤ 10μM
FRK-1-E Tyrosine-protein Kinase FRK (cluster #1 Of 1), Eukaryotic Eukaryotes 0 0.00 Binding ≤ 10μM
FYN-1-E Tyrosine-protein Kinase FYN (cluster #1 Of 5), Eukaryotic Eukaryotes 1 0.38 Binding ≤ 10μM
GAK-1-E Serine/threonine-protein Kinase GAK (cluster #1 Of 2), Eukaryotic Eukaryotes 3 0.36 Binding ≤ 10μM
HCK-1-E Tyrosine-protein Kinase HCK (cluster #1 Of 1), Eukaryotic Eukaryotes 1 0.38 Binding ≤ 10μM
JAK2-1-E Tyrosine-protein Kinase JAK2 (cluster #1 Of 1), Eukaryotic Eukaryotes 1000 0.25 Binding ≤ 10μM
KC1A-1-E Casein Kinase I Alpha (cluster #1 Of 1), Eukaryotic Eukaryotes 1 0.38 Binding ≤ 10μM
KC1E-1-E Casein Kinase I Epsilon (cluster #1 Of 2), Eukaryotic Eukaryotes 1500 0.25 Binding ≤ 10μM
KIT-1-E Stem Cell Growth Factor Receptor (cluster #1 Of 1), Eukaryotic Eukaryotes 93 0.30 Binding ≤ 10μM
KSYK-1-E Tyrosine-protein Kinase SYK (cluster #1 Of 2), Eukaryotic Eukaryotes 2900 0.23 Binding ≤ 10μM
LCK-1-E Tyrosine-protein Kinase LCK (cluster #1 Of 4), Eukaryotic Eukaryotes 0 0.00 Binding ≤ 10μM
LIMK1-1-E LIM Domain Kinase 1 (cluster #1 Of 1), Eukaryotic Eukaryotes 570 0.26 Binding ≤ 10μM
LIMK2-1-E LIM Domain Kinase 2 (cluster #1 Of 1), Eukaryotic Eukaryotes 86 0.30 Binding ≤ 10μM
LYN-1-E Tyrosine-protein Kinase Lyn (cluster #1 Of 1), Eukaryotic Eukaryotes 1 0.38 Binding ≤ 10μM
M3K4-1-E Mitogen-activated Protein Kinase Kinase Kinase 4 (cluster #1 Of 1), Eukaryotic Eukaryotes 310 0.28 Binding ≤ 10μM
M4K1-1-E Mitogen-activated Protein Kinase Kinase Kinase Kinase 1 (cluster #1 Of 1), Eukaryotic Eukaryotes 980 0.25 Binding ≤ 10μM
M4K3-1-E Mitogen-activated Protein Kinase Kinase Kinase Kinase 3 (cluster #1 Of 1), Eukaryotic Eukaryotes 640 0.26 Binding ≤ 10μM
M4K4-1-E Mitogen-activated Protein Kinase Kinase Kinase Kinase 4 (cluster #1 Of 2), Eukaryotic Eukaryotes 3100 0.23 Binding ≤ 10μM
M4K5-1-E Mitogen-activated Protein Kinase Kinase Kinase Kinase 5 (cluster #1 Of 1), Eukaryotic Eukaryotes 45 0.31 Binding ≤ 10μM
MK11-1-E MAP Kinase P38 Beta (cluster #1 Of 1), Eukaryotic Eukaryotes 410 0.27 Binding ≤ 10μM
MK12-1-E MAP Kinase P38 Gamma (cluster #1 Of 2), Eukaryotic Eukaryotes 100 0.30 Binding ≤ 10μM
MK13-1-E MAP Kinase P38 Delta (cluster #1 Of 1), Eukaryotic Eukaryotes 100 0.30 Binding ≤ 10μM
MK14-1-E MAP Kinase P38 Alpha (cluster #1 Of 3), Eukaryotic Eukaryotes 495 0.27 Binding ≤ 10μM
MLTK-1-E Mixed Lineage Kinase 7 (cluster #1 Of 1), Eukaryotic Eukaryotes 45 0.31 Binding ≤ 10μM
MP2K1-1-E Dual Specificity Mitogen-activated Protein Kinase Kinase 1 (cluster #1 Of 4), Eukaryotic Eukaryotes 1700 0.24 Binding ≤ 10μM
MP2K2-1-E Dual Specificity Mitogen-activated Protein Kinase Kinase 2 (cluster #1 Of 1), Eukaryotic Eukaryotes 1700 0.24 Binding ≤ 10μM
MRCKA-1-E Serine/threonine-protein Kinase MRCK-A (cluster #1 Of 1), Eukaryotic Eukaryotes 2000 0.24 Binding ≤ 10μM
MRCKB-1-E Serine/threonine-protein Kinase MRCK Beta (cluster #1 Of 1), Eukaryotic Eukaryotes 2100 0.24 Binding ≤ 10μM
MRCKG-1-E Serine/threonine-protein Kinase MRCK Gamma (cluster #1 Of 1), Eukaryotic Eukaryotes 1200 0.25 Binding ≤ 10μM
MST4-1-E Serine/threonine-protein Kinase MST4 (cluster #1 Of 1), Eukaryotic Eukaryotes 1900 0.24 Binding ≤ 10μM
NLK-1-E Serine/threonine Protein Kinase NLK (cluster #1 Of 1), Eukaryotic Eukaryotes 260 0.28 Binding ≤ 10μM
PGFRA-1-E Platelet-derived Growth Factor Receptor Alpha (cluster #1 Of 2), Eukaryotic Eukaryotes 63 0.31 Binding ≤ 10μM
PGFRB-1-E Platelet-derived Growth Factor Receptor Beta (cluster #1 Of 1), Eukaryotic Eukaryotes 28 0.32 Binding ≤ 10μM
PMYT1-1-E Tyrosine- And Threonine-specific Cdc2-inhibitory Kinase (cluster #1 Of 1), Eukaryotic Eukaryotes 130 0.29 Binding ≤ 10μM
PTK6-1-E Tyrosine-protein Kinase BRK (cluster #1 Of 1), Eukaryotic Eukaryotes 9 0.34 Binding ≤ 10μM
RAF1-1-E Serine/threonine-protein Kinase RAF (cluster #1 Of 1), Eukaryotic Eukaryotes 570 0.26 Binding ≤ 10μM
RET-1-E Tyrosine-protein Kinase Receptor RET (cluster #1 Of 1), Eukaryotic Eukaryotes 730 0.26 Binding ≤ 10μM
RIPK2-1-E Serine/threonine-protein Kinase RIPK2 (cluster #1 Of 1), Eukaryotic Eukaryotes 31 0.32 Binding ≤ 10μM
SIK1-1-E Serine/threonine-protein Kinase SIK1 (cluster #1 Of 1), Eukaryotic Eukaryotes 4 0.36 Binding ≤ 10μM
SIK2-1-E Serine/threonine-protein Kinase SIK2 (cluster #1 Of 1), Eukaryotic Eukaryotes 6 0.35 Binding ≤ 10μM
SLK-1-E Serine/threonine-protein Kinase 2 (cluster #1 Of 2), Eukaryotic Eukaryotes 720 0.26 Binding ≤ 10μM
SRC-1-E Tyrosine-protein Kinase SRC (cluster #1 Of 3), Eukaryotic Eukaryotes 14 0.33 Binding ≤ 10μM
SRMS-1-E Tyrosine-protein Kinase Srms (cluster #1 Of 1), Eukaryotic Eukaryotes 13 0.33 Binding ≤ 10μM
STK10-1-E Serine/threonine-protein Kinase 10 (cluster #1 Of 1), Eukaryotic Eukaryotes 1200 0.25 Binding ≤ 10μM
STK36-1-E Serine/threonine-protein Kinase 36 (cluster #1 Of 1), Eukaryotic Eukaryotes 210 0.28 Binding ≤ 10μM
TBA1A-1-E Tubulin Alpha-3 Chain (cluster #1 Of 3), Eukaryotic Eukaryotes 55 0.31 Binding ≤ 10μM
TEC-1-E Tyrosine-protein Kinase TEC (cluster #1 Of 1), Eukaryotic Eukaryotes 297 0.28 Binding ≤ 10μM
TESK1-1-E Dual Specificity Testis-specific Protein Kinase 1 (cluster #1 Of 1), Eukaryotic Eukaryotes 33 0.32 Binding ≤ 10μM
TGFR1-1-E TGF-beta Receptor Type I (cluster #1 Of 1), Eukaryotic Eukaryotes 230 0.28 Binding ≤ 10μM
TGFR2-1-E TGF-beta Receptor Type II (cluster #1 Of 1), Eukaryotic Eukaryotes 2900 0.23 Binding ≤ 10μM
TNI3K-1-E Serine/threonine-protein Kinase TNNI3K (cluster #1 Of 1), Eukaryotic Eukaryotes 11 0.34 Binding ≤ 10μM
TNIK-1-E TRAF2- And NCK-interacting Kinase (cluster #1 Of 2), Eukaryotic Eukaryotes 2000 0.24 Binding ≤ 10μM
TXK-1-E Tyrosine-protein Kinase TXK (cluster #1 Of 1), Eukaryotic Eukaryotes 2 0.37 Binding ≤ 10μM
VGFR1-1-E Vascular Endothelial Growth Factor Receptor 1 (cluster #1 Of 1), Eukaryotic Eukaryotes 5000 0.22 Binding ≤ 10μM
VGFR2-2-E Vascular Endothelial Growth Factor Receptor 2 (cluster #2 Of 2), Eukaryotic Eukaryotes 2360 0.24 Binding ≤ 10μM
WEE1-1-E Serine/threonine-protein Kinase WEE1 (cluster #1 Of 1), Eukaryotic Eukaryotes 7000 0.22 Binding ≤ 10μM
YES-1-E Tyrosine-protein Kinase YES (cluster #1 Of 1), Eukaryotic Eukaryotes 1 0.38 Binding ≤ 10μM
Z80186-1-O K562 (Erythroleukemia Cells) (cluster #1 Of 11), Other Other 1 0.38 Functional ≤ 10μM
Z80390-1-O PC-3 (Prostate Carcinoma Cells) (cluster #1 Of 10), Other Other 9 0.34 Functional ≤ 10μM
Z81017-1-O WiDr (Colon Adenocarcinoma Cells) (cluster #1 Of 5), Other Other 52 0.31 Functional ≤ 10μM
Z81252-3-O MDA-MB-231 (Breast Adenocarcinoma Cells) (cluster #3 Of 11), Other Other 12 0.34 Functional ≤ 10μM
Z81338-1-O T-cells (cluster #1 Of 3), Other Other 3 0.36 Functional ≤ 10μM
ChEMBL Target Annotations
Uniprot Swissprot Description Affinity (nM) LE (kcal/mol/atom) Type
ACVR1_HUMAN Q04771 Activin Receptor Type-1, Human 620 0.26 Binding ≤ 1μM
ACV1B_HUMAN P36896 Activin Receptor Type-1B, Human 330 0.27 Binding ≤ 1μM
AVR2A_HUMAN P27037 Activin Receptor Type-2A, Human 210 0.28 Binding ≤ 1μM
AVR2B_HUMAN Q13705 Activin Receptor Type-2B, Human 570 0.26 Binding ≤ 1μM
BCR_HUMAN P11274 Breakpoint Cluster Region Protein, Human 0.8 0.39 Binding ≤ 1μM
KC1A_HUMAN P48729 Casein Kinase I Alpha, Human 1 0.38 Binding ≤ 1μM
ADCK3_HUMAN Q8NI60 Chaperone Activity Of Bc1 Complex-like, Mitochondrial, Human 190 0.29 Binding ≤ 1μM
DDR2_HUMAN Q16832 Discoidin Domain-containing Receptor 2, Human 3.2 0.36 Binding ≤ 1μM
MP2K1_HUMAN Q02750 Dual Specificity Mitogen-activated Protein Kinase Kinase 1, Human 1000 0.25 Binding ≤ 1μM
TESK1_HUMAN Q15569 Dual Specificity Testis-specific Protein Kinase 1, Human 33 0.32 Binding ≤ 1μM
EPHA1_HUMAN P21709 Ephrin Type-A Receptor 1, Human 4.1 0.36 Binding ≤ 1μM
EPHA2_HUMAN P29317 Ephrin Type-A Receptor 2, Human 0.85 0.38 Binding ≤ 1μM
EPHA3_HUMAN P29320 Ephrin Type-A Receptor 3, Human 0.1 0.42 Binding ≤ 1μM
EPHA4_HUMAN P54764 Ephrin Type-A Receptor 4, Human 1.2 0.38 Binding ≤ 1μM
EPHA5_HUMAN P54756 Ephrin Type-A Receptor 5, Human 0.24 0.41 Binding ≤ 1μM
EPHA8_HUMAN P29322 Ephrin Type-A Receptor 8, Human 0.24 0.41 Binding ≤ 1μM
EPHB1_HUMAN P54762 Ephrin Type-B Receptor 1, Human 0.45 0.40 Binding ≤ 1μM
EPHB2_HUMAN P29323 Ephrin Type-B Receptor 2, Human 0.39 0.40 Binding ≤ 1μM
EPHB3_HUMAN P54753 Ephrin Type-B Receptor 3, Human 6.9 0.35 Binding ≤ 1μM
EPHB4_HUMAN P54760 Ephrin Type-B Receptor 4, Human 0.34 0.40 Binding ≤ 1μM
EGFR_HUMAN P00533 Epidermal Growth Factor Receptor ErbB1, Human 110 0.30 Binding ≤ 1μM
DDR1_HUMAN Q08345 Epithelial Discoidin Domain-containing Receptor 1, Human 0.69 0.39 Binding ≤ 1μM
FGFR1_HUMAN P11362 Fibroblast Growth Factor Receptor 1, Human 880 0.26 Binding ≤ 1μM
LIMK1_HUMAN P53667 LIM Domain Kinase 1, Human 114 0.29 Binding ≤ 1μM
LIMK2_HUMAN P53671 LIM Domain Kinase 2, Human 86 0.30 Binding ≤ 1μM
CSF1R_HUMAN P07333 Macrophage Colony Stimulating Factor Receptor, Human 0.58 0.39 Binding ≤ 1μM
MK14_HUMAN Q16539 MAP Kinase P38 Alpha, Human 100 0.30 Binding ≤ 1μM
MK11_HUMAN Q15759 MAP Kinase P38 Beta, Human 100 0.30 Binding ≤ 1μM
MK13_HUMAN O15264 MAP Kinase P38 Delta, Human 100 0.30 Binding ≤ 1μM
MK12_HUMAN P53778 MAP Kinase P38 Gamma, Human 100 0.30 Binding ≤ 1μM
M3K4_HUMAN Q9Y6R4 Mitogen-activated Protein Kinase Kinase Kinase 4, Human 310 0.28 Binding ≤ 1μM
M4K1_HUMAN Q92918 Mitogen-activated Protein Kinase Kinase Kinase Kinase 1, Human 980 0.25 Binding ≤ 1μM
M4K3_HUMAN Q8IVH8 Mitogen-activated Protein Kinase Kinase Kinase Kinase 3, Human 640 0.26 Binding ≤ 1μM
M4K5_HUMAN Q9Y4K4 Mitogen-activated Protein Kinase Kinase Kinase Kinase 5, Human 45 0.31 Binding ≤ 1μM
MLTK_HUMAN Q9NYL2 Mixed Lineage Kinase 7, Human 45 0.31 Binding ≤ 1μM
PGFRA_HUMAN P16234 Platelet-derived Growth Factor Receptor Alpha, Human 0.47 0.40 Binding ≤ 1μM
PGFRB_HUMAN P09619 Platelet-derived Growth Factor Receptor Beta, Human 0.63 0.39 Binding ≤ 1μM
ERBB2_HUMAN P04626 Receptor Protein-tyrosine Kinase ErbB-2, Human 710 0.26 Binding ≤ 1μM
NLK_HUMAN Q9UBE8 Serine/threonine Protein Kinase NLK, Human 260 0.28 Binding ≤ 1μM
SLK_HUMAN Q9H2G2 Serine/threonine-protein Kinase 2, Human 720 0.26 Binding ≤ 1μM
STK36_HUMAN Q9NRP7 Serine/threonine-protein Kinase 36, Human 210 0.28 Binding ≤ 1μM
BRAF_HUMAN P15056 Serine/threonine-protein Kinase B-raf, Human 500 0.27 Binding ≤ 1μM
GAK_HUMAN O14976 Serine/threonine-protein Kinase GAK, Human 2.6 0.36 Binding ≤ 1μM
RAF1_HUMAN P04049 Serine/threonine-protein Kinase RAF, Human 164 0.29 Binding ≤ 1μM
ACVL1_HUMAN P37023 Serine/threonine-protein Kinase Receptor R3, Human 460 0.27 Binding ≤ 1μM
RIPK2_HUMAN O43353 Serine/threonine-protein Kinase RIPK2, Human 109 0.30 Binding ≤ 1μM
SIK1_HUMAN P57059 Serine/threonine-protein Kinase SIK1, Human 3.9 0.36 Binding ≤ 1μM
SIK2_HUMAN Q9H0K1 Serine/threonine-protein Kinase SIK2, Human 6.4 0.35 Binding ≤ 1μM
TNI3K_HUMAN Q59H18 Serine/threonine-protein Kinase TNNI3K, Human 11 0.34 Binding ≤ 1μM
KIT_HUMAN P10721 Stem Cell Growth Factor Receptor, Human 0.62 0.39 Binding ≤ 1μM
TGFR1_HUMAN P36897 TGF-beta Receptor Type I, Human 230 0.28 Binding ≤ 1μM
TBA1A_RAT P68370 Tubulin Alpha-1 Chain, Rat 55 0.31 Binding ≤ 1μM
ACK1_HUMAN Q07912 Tyrosine Kinase Non-receptor Protein 2, Human 5.6 0.35 Binding ≤ 1μM
PMYT1_HUMAN Q99640 Tyrosine- And Threonine-specific Cdc2-inhibitory Kinase, Human 130 0.29 Binding ≤ 1μM
ABL1_HUMAN P00519 Tyrosine-protein Kinase ABL, Human 0.53 0.39 Binding ≤ 1μM
ABL2_HUMAN P42684 Tyrosine-protein Kinase ABL2, Human 0.17 0.41 Binding ≤ 1μM
BLK_HUMAN P51451 Tyrosine-protein Kinase BLK, Human 0.21 0.41 Binding ≤ 1μM
BLK_MOUSE P16277 Tyrosine-protein Kinase BLK, Mouse 8 0.34 Binding ≤ 1μM
BMX_HUMAN P51813 Tyrosine-protein Kinase BMX, Human 1.4 0.38 Binding ≤ 1μM
PTK6_HUMAN Q13882 Tyrosine-protein Kinase BRK, Human 7.8 0.34 Binding ≤ 1μM
BTK_HUMAN Q06187 Tyrosine-protein Kinase BTK, Human 1.3 0.38 Binding ≤ 1μM
CSK_HUMAN P41240 Tyrosine-protein Kinase CSK, Human 1 0.38 Binding ≤ 1μM
FGR_HUMAN P09769 Tyrosine-protein Kinase FGR, Human 0.5 0.39 Binding ≤ 1μM
FRK_HUMAN P42685 Tyrosine-protein Kinase FRK, Human 0.31 0.40 Binding ≤ 1μM
FYN_HUMAN P06241 Tyrosine-protein Kinase FYN, Human 0.2 0.41 Binding ≤ 1μM
HCK_HUMAN P08631 Tyrosine-protein Kinase HCK, Human 0.35 0.40 Binding ≤ 1μM
JAK2_HUMAN O60674 Tyrosine-protein Kinase JAK2, Human 1000 0.25 Binding ≤ 1μM
LCK_MOUSE P06240 Tyrosine-protein Kinase LCK, Mouse 0.1 0.42 Binding ≤ 1μM
LCK_HUMAN P06239 Tyrosine-protein Kinase LCK, Human 0.2 0.41 Binding ≤ 1μM
LYN_HUMAN P07948 Tyrosine-protein Kinase Lyn, Human 0.57 0.39 Binding ≤ 1μM
RET_HUMAN P07949 Tyrosine-protein Kinase Receptor RET, Human 390 0.27 Binding ≤ 1μM
SRC_HUMAN P12931 Tyrosine-protein Kinase SRC, Human 0.21 0.41 Binding ≤ 1μM
SRC_CHICK P00523 Tyrosine-protein Kinase SRC, Chick 0.4 0.40 Binding ≤ 1μM
SRMS_HUMAN Q9H3Y6 Tyrosine-protein Kinase Srms, Human 13 0.33 Binding ≤ 1μM
TEC_HUMAN P42680 Tyrosine-protein Kinase TEC, Human 13 0.33 Binding ≤ 1μM
TXK_HUMAN P42681 Tyrosine-protein Kinase TXK, Human 0.3 0.40 Binding ≤ 1μM
YES_HUMAN P07947 Tyrosine-protein Kinase YES, Human 0.3 0.40 Binding ≤ 1μM
ACVR1_HUMAN Q04771 Activin Receptor Type-1, Human 620 0.26 Binding ≤ 10μM
ACV1B_HUMAN P36896 Activin Receptor Type-1B, Human 330 0.27 Binding ≤ 10μM
AVR2A_HUMAN P27037 Activin Receptor Type-2A, Human 210 0.28 Binding ≤ 10μM
AVR2B_HUMAN Q13705 Activin Receptor Type-2B, Human 570 0.26 Binding ≤ 10μM
BCR_HUMAN P11274 Breakpoint Cluster Region Protein, Human 0.8 0.39 Binding ≤ 10μM
KC1A_HUMAN P48729 Casein Kinase I Alpha, Human 1 0.38 Binding ≤ 10μM
KC1E_HUMAN P49674 Casein Kinase I Epsilon, Human 1500 0.25 Binding ≤ 10μM
ADCK3_HUMAN Q8NI60 Chaperone Activity Of Bc1 Complex-like, Mitochondrial, Human 190 0.29 Binding ≤ 10μM
DDR2_HUMAN Q16832 Discoidin Domain-containing Receptor 2, Human 3.2 0.36 Binding ≤ 10μM
MP2K1_HUMAN Q02750 Dual Specificity Mitogen-activated Protein Kinase Kinase 1, Human 1000 0.25 Binding ≤ 10μM
MP2K2_HUMAN P36507 Dual Specificity Mitogen-activated Protein Kinase Kinase 2, Human 1400 0.25 Binding ≤ 10μM
TESK1_HUMAN Q15569 Dual Specificity Testis-specific Protein Kinase 1, Human 33 0.32 Binding ≤ 10μM
EPHA1_HUMAN P21709 Ephrin Type-A Receptor 1, Human 4.1 0.36 Binding ≤ 10μM
EPHA2_HUMAN P29317 Ephrin Type-A Receptor 2, Human 0.85 0.38 Binding ≤ 10μM
EPHA3_HUMAN P29320 Ephrin Type-A Receptor 3, Human 0.1 0.42 Binding ≤ 10μM
EPHA4_HUMAN P54764 Ephrin Type-A Receptor 4, Human 1.2 0.38 Binding ≤ 10μM
EPHA5_HUMAN P54756 Ephrin Type-A Receptor 5, Human 0.24 0.41 Binding ≤ 10μM
EPHA8_HUMAN P29322 Ephrin Type-A Receptor 8, Human 0.24 0.41 Binding ≤ 10μM
EPHB1_HUMAN P54762 Ephrin Type-B Receptor 1, Human 0.45 0.40 Binding ≤ 10μM
EPHB2_HUMAN P29323 Ephrin Type-B Receptor 2, Human 0.39 0.40 Binding ≤ 10μM
EPHB3_HUMAN P54753 Ephrin Type-B Receptor 3, Human 6.9 0.35 Binding ≤ 10μM
EPHB4_HUMAN P54760 Ephrin Type-B Receptor 4, Human 0.34 0.40 Binding ≤ 10μM
EGFR_HUMAN P00533 Epidermal Growth Factor Receptor ErbB1, Human 110 0.30 Binding ≤ 10μM
DDR1_HUMAN Q08345 Epithelial Discoidin Domain-containing Receptor 1, Human 0.69 0.39 Binding ≤ 10μM
E2AK4_HUMAN Q9P2K8 Eukaryotic Translation Initiation Factor 2-alpha Kinase 4, Human 1600 0.25 Binding ≤ 10μM
FGFR1_HUMAN P11362 Fibroblast Growth Factor Receptor 1, Human 3700 0.23 Binding ≤ 10μM
FGFR2_HUMAN P21802 Fibroblast Growth Factor Receptor 2, Human 1400 0.25 Binding ≤ 10μM
LIMK1_HUMAN P53667 LIM Domain Kinase 1, Human 114 0.29 Binding ≤ 10μM
LIMK2_HUMAN P53671 LIM Domain Kinase 2, Human 86 0.30 Binding ≤ 10μM
CSF1R_HUMAN P07333 Macrophage Colony Stimulating Factor Receptor, Human 0.58 0.39 Binding ≤ 10μM
MK14_HUMAN Q16539 MAP Kinase P38 Alpha, Human 100 0.30 Binding ≤ 10μM
MK11_HUMAN Q15759 MAP Kinase P38 Beta, Human 100 0.30 Binding ≤ 10μM
MK13_HUMAN O15264 MAP Kinase P38 Delta, Human 100 0.30 Binding ≤ 10μM
MK12_HUMAN P53778 MAP Kinase P38 Gamma, Human 100 0.30 Binding ≤ 10μM
M3K4_HUMAN Q9Y6R4 Mitogen-activated Protein Kinase Kinase Kinase 4, Human 310 0.28 Binding ≤ 10μM
M4K1_HUMAN Q92918 Mitogen-activated Protein Kinase Kinase Kinase Kinase 1, Human 980 0.25 Binding ≤ 10μM
M4K3_HUMAN Q8IVH8 Mitogen-activated Protein Kinase Kinase Kinase Kinase 3, Human 640 0.26 Binding ≤ 10μM
M4K4_HUMAN O95819 Mitogen-activated Protein Kinase Kinase Kinase Kinase 4, Human 3100 0.23 Binding ≤ 10μM
M4K5_HUMAN Q9Y4K4 Mitogen-activated Protein Kinase Kinase Kinase Kinase 5, Human 45 0.31 Binding ≤ 10μM
MLTK_HUMAN Q9NYL2 Mixed Lineage Kinase 7, Human 45 0.31 Binding ≤ 10μM
DMPK_HUMAN Q09013 Myotonin-protein Kinase, Human 1300 0.25 Binding ≤ 10μM
PGFRA_HUMAN P16234 Platelet-derived Growth Factor Receptor Alpha, Human 0.47 0.40 Binding ≤ 10μM
PGFRB_HUMAN P09619 Platelet-derived Growth Factor Receptor Beta, Human 0.63 0.39 Binding ≤ 10μM
ERBB2_HUMAN P04626 Receptor Protein-tyrosine Kinase ErbB-2, Human 1400 0.25 Binding ≤ 10μM
NLK_HUMAN Q9UBE8 Serine/threonine Protein Kinase NLK, Human 260 0.28 Binding ≤ 10μM
STK10_HUMAN O94804 Serine/threonine-protein Kinase 10, Human 1200 0.25 Binding ≤ 10μM
SLK_HUMAN Q9H2G2 Serine/threonine-protein Kinase 2, Human 720 0.26 Binding ≤ 10μM
STK36_HUMAN Q9NRP7 Serine/threonine-protein Kinase 36, Human 210 0.28 Binding ≤ 10μM
AURKB_HUMAN Q96GD4 Serine/threonine-protein Kinase Aurora-B, Human 6485 0.22 Binding ≤ 10μM
BRAF_HUMAN P15056 Serine/threonine-protein Kinase B-raf, Human 500 0.27 Binding ≤ 10μM
GAK_HUMAN O14976 Serine/threonine-protein Kinase GAK, Human 2.6 0.36 Binding ≤ 10μM
MRCKB_HUMAN Q9Y5S2 Serine/threonine-protein Kinase MRCK Beta, Human 2100 0.24 Binding ≤ 10μM
MRCKG_HUMAN Q6DT37 Serine/threonine-protein Kinase MRCK Gamma, Human 1200 0.25 Binding ≤ 10μM
MRCKA_HUMAN Q5VT25 Serine/threonine-protein Kinase MRCK-A, Human 2000 0.24 Binding ≤ 10μM
MST4_HUMAN Q9P289 Serine/threonine-protein Kinase MST4, Human 1900 0.24 Binding ≤ 10μM
RAF1_HUMAN P04049 Serine/threonine-protein Kinase RAF, Human 164 0.29 Binding ≤ 10μM
ACVL1_HUMAN P37023 Serine/threonine-protein Kinase Receptor R3, Human 460 0.27 Binding ≤ 10μM
RIPK2_HUMAN O43353 Serine/threonine-protein Kinase RIPK2, Human 109 0.30 Binding ≤ 10μM
SIK1_HUMAN P57059 Serine/threonine-protein Kinase SIK1, Human 3.9 0.36 Binding ≤ 10μM
SIK2_HUMAN Q9H0K1 Serine/threonine-protein Kinase SIK2, Human 6.4 0.35 Binding ≤ 10μM
TNI3K_HUMAN Q59H18 Serine/threonine-protein Kinase TNNI3K, Human 11 0.34 Binding ≤ 10μM
WEE1_HUMAN P30291 Serine/threonine-protein Kinase WEE1, Human 7000 0.22 Binding ≤ 10μM
KIT_HUMAN P10721 Stem Cell Growth Factor Receptor, Human 0.62 0.39 Binding ≤ 10μM
TGFR1_HUMAN P36897 TGF-beta Receptor Type I, Human 230 0.28 Binding ≤ 10μM
TGFR2_HUMAN P37173 TGF-beta Receptor Type II, Human 2900 0.23 Binding ≤ 10μM
TNIK_HUMAN Q9UKE5 TRAF2- And NCK-interacting Kinase, Human 2000 0.24 Binding ≤ 10μM
TBA1A_RAT P68370 Tubulin Alpha-1 Chain, Rat 55 0.31 Binding ≤ 10μM
ACK1_HUMAN Q07912 Tyrosine Kinase Non-receptor Protein 2, Human 5.6 0.35 Binding ≤ 10μM
PMYT1_HUMAN Q99640 Tyrosine- And Threonine-specific Cdc2-inhibitory Kinase, Human 130 0.29 Binding ≤ 10μM
ABL1_HUMAN P00519 Tyrosine-protein Kinase ABL, Human 0.53 0.39 Binding ≤ 10μM
ABL2_HUMAN P42684 Tyrosine-protein Kinase ABL2, Human 0.17 0.41 Binding ≤ 10μM
BLK_HUMAN P51451 Tyrosine-protein Kinase BLK, Human 0.21 0.41 Binding ≤ 10μM
BLK_MOUSE P16277 Tyrosine-protein Kinase BLK, Mouse 8 0.34 Binding ≤ 10μM
BMX_HUMAN P51813 Tyrosine-protein Kinase BMX, Human 1.4 0.38 Binding ≤ 10μM
PTK6_HUMAN Q13882 Tyrosine-protein Kinase BRK, Human 7.8 0.34 Binding ≤ 10μM
BTK_HUMAN Q06187 Tyrosine-protein Kinase BTK, Human 1.3 0.38 Binding ≤ 10μM
CSK_HUMAN P41240 Tyrosine-protein Kinase CSK, Human 1 0.38 Binding ≤ 10μM
FGR_HUMAN P09769 Tyrosine-protein Kinase FGR, Human 0.5 0.39 Binding ≤ 10μM
FRK_HUMAN P42685 Tyrosine-protein Kinase FRK, Human 0.31 0.40 Binding ≤ 10μM
FYN_HUMAN P06241 Tyrosine-protein Kinase FYN, Human 0.2 0.41 Binding ≤ 10μM
HCK_HUMAN P08631 Tyrosine-protein Kinase HCK, Human 0.35 0.40 Binding ≤ 10μM
JAK2_HUMAN O60674 Tyrosine-protein Kinase JAK2, Human 1000 0.25 Binding ≤ 10μM
LCK_HUMAN P06239 Tyrosine-protein Kinase LCK, Human 0.2 0.41 Binding ≤ 10μM
LCK_MOUSE P06240 Tyrosine-protein Kinase LCK, Mouse 0.1 0.42 Binding ≤ 10μM
LYN_HUMAN P07948 Tyrosine-protein Kinase Lyn, Human 0.57 0.39 Binding ≤ 10μM
FLT3_HUMAN P36888 Tyrosine-protein Kinase Receptor FLT3, Human 8100 0.22 Binding ≤ 10μM
RET_HUMAN P07949 Tyrosine-protein Kinase Receptor RET, Human 2100 0.24 Binding ≤ 10μM
SRC_CHICK P00523 Tyrosine-protein Kinase SRC, Chick 0.4 0.40 Binding ≤ 10μM
SRC_HUMAN P12931 Tyrosine-protein Kinase SRC, Human 0.21 0.41 Binding ≤ 10μM
SRMS_HUMAN Q9H3Y6 Tyrosine-protein Kinase Srms, Human 13 0.33 Binding ≤ 10μM
KSYK_HUMAN P43405 Tyrosine-protein Kinase SYK, Human 2900 0.23 Binding ≤ 10μM
TEC_HUMAN P42680 Tyrosine-protein Kinase TEC, Human 13 0.33 Binding ≤ 10μM
TXK_HUMAN P42681 Tyrosine-protein Kinase TXK, Human 0.3 0.40 Binding ≤ 10μM
YES_HUMAN P07947 Tyrosine-protein Kinase YES, Human 0.3 0.40 Binding ≤ 10μM
VGFR1_HUMAN P17948 Vascular Endothelial Growth Factor Receptor 1, Human 5000 0.22 Binding ≤ 10μM
VGFR2_HUMAN P35968 Vascular Endothelial Growth Factor Receptor 2, Human 2360 0.24 Binding ≤ 10μM
Z80186 Z80186 K562 (Erythroleukemia Cells) 1 0.38 Functional ≤ 10μM
Z81252 Z81252 MDA-MB-231 (Breast Adenocarcinoma Cells) 12 0.34 Functional ≤ 10μM
Z80390 Z80390 PC-3 (Prostate Carcinoma Cells) 9.4 0.34 Functional ≤ 10μM
Z81338 Z81338 T-cells 3 0.36 Functional ≤ 10μM
Z81017 Z81017 WiDr (Colon Adenocarcinoma Cells) 52 0.31 Functional ≤ 10μM

Reactome Annotations from Targets (via Uniprot)

Description Species
Activated point mutants of FGFR2
activated TAK1 mediates p38 MAPK activation
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
Activation of the AP-1 family of transcription factors
ADP signalling through P2Y purinoceptor 1
Antigen activates B Cell Receptor (BCR) leading to generation of second messenge
APC truncation mutants have impaired AXIN binding
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins
Apoptotic cleavage of cellular proteins
ARMS-mediated activation
AXIN missense mutants destabilize the destruction complex
Beta-catenin phosphorylation cascade
c-src mediated regulation of Cx43 function and closure of gap junctions
Ca2+ pathway
CD28 co-stimulation
CD28 dependent PI3K/Akt signaling
CD28 dependent Vav1 pathway
CDO in myogenesis
Cell surface interactions at the vascular wall
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
Circadian Clock
Constitutive PI3K/AKT Signaling in Cancer
CREB phosphorylation through the activation of Ras
CRMPs in Sema3A signaling
CTLA4 inhibitory signaling
Cyclin A/B1 associated events during G2/M transition
Cyclin A:Cdk2-associated events at S phase entry
Cyclin E associated events during G1/S transition
DAP12 signaling
DCC mediated attractive signaling
Degradation of beta-catenin by the destruction complex
disassembly of the destruction complex and recruitment of AXIN to the membrane
Downregulation of ERBB2:ERBB3 signaling
Downregulation of TGF-beta receptor signaling
Downstream signal transduction
Downstream TCR signaling
DSCAM interactions
EGFR downregulation
EGFR interacts with phospholipase C-gamma
EGFR Transactivation by Gastrin
EPH-ephrin mediated repulsion of cells
EPH-Ephrin signaling
EPHA-mediated growth cone collapse
EPHB-mediated forward signaling
Ephrin signaling
ERK/MAPK targets
ERK1 activation
ERK2 activation
Factors involved in megakaryocyte development and platelet production
Fc epsilon receptor (FCERI) signaling
FCERI mediated Ca+2 mobilization
FCERI mediated MAPK activation
FCERI mediated NF-kB activation
FCGR activation
Formation of tubulin folding intermediates by CCT/TriC
Frs2-mediated activation
G2/M DNA replication checkpoint
GAB1 signalosome
Gap junction assembly
Generation of second messenger molecules
Golgi Associated Vesicle Biogenesis
GP1b-IX-V activation signalling
GPVI-mediated activation cascade
GRB2 events in EGFR signaling
GRB2 events in ERBB2 signaling
GRB2:SOS provides linkage to MAPK signaling for Integrins
GRB7 events in ERBB2 signaling
Growth hormone receptor signaling
Integrin alphaIIb beta3 signaling
Integrin cell surface interactions
Interferon gamma signaling
Interleukin receptor SHC signaling
Interleukin-1 signaling
Interleukin-2 signaling
Interleukin-3, 5 and GM-CSF signaling
Interleukin-6 signaling
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human
Kinesins
KSRP destabilizes mRNA
L1CAM interactions
Loss of Nlp from mitotic centrosomes
Loss of proteins required for interphase microtubule organization from the ce
MEK activation
MHC class II antigen presentation
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane
misspliced GSK3beta mutants stabilize beta-catenin
Mitotic Prometaphase
MyD88:Mal cascade initiated on plasma membrane
NCAM signaling for neurite out-growth
Nef and signal transduction
Nef Mediated CD4 Down-regulation
Nephrin interactions
Netrin mediated repulsion signals
Neurophilin interactions with VEGF and VEGFR
NOD1/2 Signaling Pathway
Non-integrin membrane-ECM interactions
Oxidative Stress Induced Senescence
p130Cas linkage to MAPK signaling for integrins
p38MAPK events
p75NTR recruits signalling complexes
PD-1 signaling
PECAM1 interactions
Phosphorylation of CD3 and TCR zeta chains
PI3K events in ERBB2 signaling
PIP3 activates AKT signaling
Platelet Adhesion to exposed collagen
Platelet sensitization by LDL
PLCG1 events in ERBB2 signaling
Polo-like kinase mediated events
Post-chaperonin tubulin folding pathway
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
Prefoldin mediated transfer of substrate to CCT/TriC
Prolactin receptor signaling
RAF activation
RAF phosphorylates MEK
Rap1 signalling
Recruitment of mitotic centrosome proteins and complexes
Recruitment of NuMA to mitotic centrosomes
Recycling pathway of L1
Regulation of actin dynamics for phagocytic cup formation
Regulation of cytoskeletal remodeling and cell spreading by IPP complex componen
Regulation of IFNG signaling
Regulation of KIT signaling
Regulation of PLK1 Activity at G2/M Transition
Regulation of signaling by CBL
Regulation of signaling by NODAL
Resolution of Sister Chromatid Cohesion
Rho GTPase cycle
RMTs methylate histone arginines
Role of Abl in Robo-Slit signaling
Role of LAT2/NTAL/LAB on calcium mobilization
Role of phospholipids in phagocytosis
S33 mutants of beta-catenin aren't phosphorylated
S37 mutants of beta-catenin aren't phosphorylated
S45 mutants of beta-catenin aren't phosphorylated
Sema3A PAK dependent Axon repulsion
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
Sema4D induced cell migration and growth-cone collapse
Separation of Sister Chromatids
SHC1 events in EGFR signaling
SHC1 events in ERBB2 signaling
Signal regulatory protein (SIRP) family interactions
Signal transduction by L1
Signaling by activated point mutants of FGFR1
Signaling by Activin
Signaling by BMP
Signaling by constitutively active EGFR
Signaling by EGFR
Signaling by ERBB2
Signaling by ERBB4
Signaling by FGFR
Signaling by FGFR mutants
Signaling by FGFR1 fusion mutants
Signaling by FGFR2 amplification mutants
Signaling by Leptin
Signaling by NODAL
Signaling by PDGF
Signaling by SCF-KIT
Signalling to p38 via RIT and RIN
SMAD2/3 MH2 Domain Mutants in Cancer
SMAD2/3 Phosphorylation Motif Mutants in Cancer
Spry regulation of FGF signaling
Stimuli-sensing channels
T41 mutants of beta-catenin aren't phosphorylated
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
TGF-beta receptor signaling activates SMADs
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
TGFBR1 KD Mutants in Cancer
TGFBR1 LBD Mutants in Cancer
TGFBR2 Kinase Domain Mutants in Cancer
TGFBR2 MSI Frameshift Mutants in Cancer
Thrombin signalling through proteinase activated receptors (PARs)
Translocation of GLUT4 to the plasma membrane
Translocation of ZAP-70 to Immunological synapse
truncations of AMER1 destabilize the destruction complex
Uptake and function of anthrax toxins
VEGF binds to VEGFR leading to receptor dimerization
VEGFA-VEGFR2 Pathway
VEGFR2 mediated cell proliferation
WNT mediated activation of DVL

Analogs ( Draw Identity 99% 90% 80% 70% )