UCSF

ZINC00968257

Draw Identity 99% 90% 80% 70%

Substance Information

In ZINC since Heavy atoms Benign functionality
September 27th, 2005 21 Yes

Popular Name: Amitriptyline hydrochloride Amitriptyline hydrochloride

Find On: PubMed — Wikipedia — Google

CAS Numbers: 342611-00-1 , 50-48-6 , 549-18-8 , 549-18-8, 50-48-6 , [50-48-6] , [549-18-8]

Other Names:

triptyline

1-Propanamine, 3-(10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5-ylidene)-N,N-dimethyl-, hydrochloride; 10,11-Dihydro-N,N-dimethyl-5H-dibenzo(a,d)cycloheptene-delta(sup 5,gamma)-propylamine hydrochloride; 5-(3-Dimethylaminopropylidene)dibenzo(a,d)(1,4)cyclohe

1-propanamine, 3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-

10,11-Dihydro-5-(gamma-dimethylaminopropylidene)-5H-dibenzo(a,d)cycloheptene

10,11-dihydro-5-(gamma-dimethylaminopropylidene)-5H-dibenzo(a,d)cycloheptene; 10,11-dihydro-N,N-dimethyl-5H-dibenzo(a,d)heptalene-Delta(5),gamma-propylamine; 3-(10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine; 3-(10,11-dihyd

10,11-dihydro-5-(gamma-dimethylaminopropylidene)-5H-dibenzo[a,d]cycloheptene

10,11-Dihydro-N,N-dimethyl-5H-dibenzo(a,d)heptalene-delta(5),gamma-propylamine

17086-03-2 (pamoate (2:1))

3-(10,11-Dihydro-5H-dibenzo(a,d)cyclohepten-5-yliden)-N,N-dimethylpropylamin

3-(10,11-dihydro-5h-dibenzo[a,d]cycloheptene-5-ylidene)-n,n-dimethyl-1-propanamine hydrochloride

3-(10,11-Dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N,N-dimethyl-1-propanamine

3-(10,11-Dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N,N-dimethyl-1-propanamine hydrochloride

3-(10,11-Dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N,N-dimethylpropan-1-amine

30227-34-0 (maleate (1:1))

5-(3'-Dimethylaminopropylidene)-dibenzo-(a,d)(1,4)-cycloheptadiene

5-(3'-Dimethylaminopropylidene)-dibenzo-[a,d][1,4]-cycloheptadiene

5-(3-(Dimethylamino)propylidene) dibenzosuberane HCl

5-(3-Dimethylaminopropylidene)-10,11-dihydro-5H-dibenzo(a,d)cycloheptatriene

5-(3-Dimethylaminopropylidene)-10,11-dihydro-5H-dibenzo(a,d)cycloheptene

5-(3-Dimethylaminopropylidene)-5H-dibenzo[a,d]-10,11-dihydrocycloheptene

5-(3-dimethylaminopropylidene)dibenzo[a,d][1,4]-cycloheptadiene

5-(gamma-Dimethylaminopropylidene)-10,11-dihydro-5H-dibenzo(a,d)cycloheptene

5-(gamma-Dimethylaminopropylidene)-5H-dibenzo(a,d)(1,4)cycloheptadiene

5-(gamma-Dimethylaminopropylidene)-5H-dibenzo[a,d]10,11-dihydrocycloheptene

5-(gamma-Dimethylaminopropylidene)-5H-Dibenzo[a,d][1,4]cycloheptadiene

5-(gamma-Dimethylaminopropylidine)-5H-dibenzo(a,d)(1,4)cycloheptadiene

50-48-6

50-48-6; Amitriptyline (INN); D07448; Laroxyl (TN)

50-48-6; Amitriptyline; C06824

549-18-8 (hydrochloride)

549-18-8; Amitriptyline hydrochloride (JP16/USP); D00809; Elavil (TN)

549-18-8; Amitryptiline hydrochloride; Prestwick_20

549-18-8; Annoyltin; CPD000058368; SAM002554886

AB00514631

AC1L1D20

Adepress

Adepril

AKOS000512694

Amitid

Amitril

Amitriprolidine

Amitriprolidine;Amitriptylin;Amitryptiline;Amitryptyline;Amytriptiline

Amitriptilina

Amitriptilina [INN-Spanish]

Amitriptilina [Italian]

Amitriptylin

Amitriptylin [German]

Amitriptyline

Amitriptyline (BAN

Amitriptyline (hydrochloride)

Amitriptyline (INN)

Amitriptyline HCl

Amitriptyline hydrochloride; Annoyltin; CPD000058368; SAM002554886

AMITRIPTYLINE HYDROCHLORIDE; CHLORDIAZEPOXIDE; CHLORDIAZEPOXIDE AND AMITRIPTYLINE HYDROCHLORIDE; LS-187825

Amitriptyline [INN:BAN]

Amitriptyline-d3Hydrochloride

Amitriptyline;Amitriptyline hydrochloride

Amitriptylinum

Amitriptylinum [INN-Latin]

Amitriptylline hydrochloride

Amitryptiline

Amitryptiline hydrochloride

Amitryptyline

AMITRYPTYLLINE NA

Amytriptiline

Amytriptylin

BAS 00269727

BIDD:GT0115

BPBio1_000317

BRD-K53737926-003-05-4

BRN 2217885

BSPBio_000287

BSPBio_001836

C06824

CAS-549-18-8

CCRIS 9174

CHEBI:2666

CHEMBL629

CID2160

cMAP_000001

D07448

Damilan

Damilen

dAmitriptyline

DAP000864

DB00321

DIHYDRODIBENZOANNULENYLIDENEDIMETHYLPROPANAMIN

DIHYDRODIBENZOANNULENYLIDENEDIMETHYLPROPANAMINEHYDROCHLORID

DivK1c_000766

EINECS 200-041-6

Elanil

Elavil

Endep

Flavyl

Hexathane

Horizon

IDI1_000766

INN); Amitriptyline HCl (FDA

INN); Amitriptyline Hydrochloride (FDA

JAN

JAN)

KBio1_000766

KBio2_000424

KBio2_002261

KBio2_002992

KBio2_004829

KBio2_005560

KBio2_007397

KBio3_001336

KBio3_002741

KBioGR_000592

KBioGR_002261

KBioSS_000424

KBioSS_002262

L001041

Lantron

Laroxil

Laroxyl

Laroxyl (TN)

Lentizol

LS-60747

MFCD00012537

MFCD00412072

MK 230

MolPort-001-662-651

N 750

N/A

NCGC00015095-01

NCGC00015095-02

NCGC00015095-03

NCGC00015095-10

NCGC00024433-04

NINDS_000766

NSC169910

Oprea1_479304

PDSP1_001564

PDSP2_001548

Prestwick0_000074

Prestwick1_000074

Prestwick2_000074

Prestwick3_000074

Proheptadiene

Redomex

Ro 4-1575

Saroten

Sarotex

Seroten

SPBio_000082

SPBio_002208

Spectrum2_000101

Spectrum3_000298

Spectrum4_000146

Spectrum5_000806

Spectrum_000044

STK525215

STOCK1S-56825

Sylvemid

TP0

Triptanol

Triptilin

Triptisol

Tryptanol

Tryptizol

UNII-1806D8D52K

USP

USP)

[3-(10,11-Dihydro-dibenzo[a,d]cyclohepten-5-ylidene)-propyl]-dimethyl-amine

Download: MOL2 SDF SMILES Flexibase

Annotations

Vendors

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 4.19 12.75 -36.66 1 1 1 4 278.419 3 ↓

Vendor Notes

Note Type Comments Provided By
MP 195 TCI
ALOGPS_SOLUBILITY 4.50e-03 g/l DrugBank-approved
Target 5-HT Receptor Selleck Chemicals
Indications Antidepressant KeyOrganics Bioactives
Patent Database Links EP1078637; EP1438962; EP1627639; EP1655029; EP1671628; EP1685843; EP1700601; EP1700616; EP1731142; EP1815846; EP1829527; EP1829528; EP1829539; EP1844769; EP1867641; EP1884243; EP1946777; EP1990639; US2004142904; US2004254182; US2005070552; US2005281845; U ChEBI
Warnings IRRITANT Matrix Scientific
PUBCHEM_SUBSTANCE_COMMENT NCC_SAMPLE_SUPPLIER : LightBiologicals; NCC_SUPPLIER_STRUCTURE_ID : A-7371; NCC_SUPPLIER_SAMPLE_COMMENTS : WHITE POWDER; 1 hydrogen chloride NIH Clinical Collection via PubChem
PUBCHEM_SUBSTANCE_COMMENT SAMPLE_SUPPLIER: LightBiologicals; SUPPLIER_STRUCTURE_ID: A-7371; SALT: 1 hydrogen chloride; SUPPLIER_COMMENTS: WHITE POWDER NIH Clinical Collection via PubChem
Therapy Tricyclic antidepressant SMDC Iconix

Activity (Go SEA)

Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
5HT1A-1-E Serotonin 1a (5-HT1a) Receptor (cluster #1 Of 4), Eukaryotic Eukaryotes 44 0.49 Binding ≤ 10μM
5HT1B-1-E Serotonin 1b (5-HT1b) Receptor (cluster #1 Of 2), Eukaryotic Eukaryotes 44 0.49 Binding ≤ 10μM
5HT1D-1-E Serotonin 1d (5-HT1d) Receptor (cluster #1 Of 2), Eukaryotic Eukaryotes 44 0.49 Binding ≤ 10μM
5HT1F-1-E Serotonin 1f (5-HT1f) Receptor (cluster #1 Of 2), Eukaryotic Eukaryotes 44 0.49 Binding ≤ 10μM
5HT2A-1-E Serotonin 2a (5-HT2a) Receptor (cluster #1 Of 3), Eukaryotic Eukaryotes 44 0.49 Binding ≤ 10μM
5HT2B-1-E Serotonin 2b (5-HT2b) Receptor (cluster #1 Of 4), Eukaryotic Eukaryotes 44 0.49 Binding ≤ 10μM
5HT2C-1-E Serotonin 2c (5-HT2c) Receptor (cluster #1 Of 3), Eukaryotic Eukaryotes 44 0.49 Binding ≤ 10μM
5HT4R-1-E Serotonin 4 (5-HT4) Receptor (cluster #1 Of 1), Eukaryotic Eukaryotes 44 0.49 Binding ≤ 10μM
5HT5A-1-E Serotonin 5a (5-HT5a) Receptor (cluster #1 Of 1), Eukaryotic Eukaryotes 44 0.49 Binding ≤ 10μM
5HT5B-1-E Serotonin 5b (5-HT5b) Receptor (cluster #1 Of 1), Eukaryotic Eukaryotes 44 0.49 Binding ≤ 10μM
5HT6R-1-E Serotonin 6 (5-HT6) Receptor (cluster #1 Of 2), Eukaryotic Eukaryotes 44 0.49 Binding ≤ 10μM
5HT7R-1-E Serotonin 7 (5-HT7) Receptor (cluster #1 Of 3), Eukaryotic Eukaryotes 44 0.49 Binding ≤ 10μM
ACM1-1-E Muscarinic Acetylcholine Receptor M1 (cluster #1 Of 5), Eukaryotic Eukaryotes 3000 0.37 Binding ≤ 10μM
ACM2-1-E Muscarinic Acetylcholine Receptor M2 (cluster #1 Of 6), Eukaryotic Eukaryotes 3000 0.37 Binding ≤ 10μM
ACM3-4-E Muscarinic Acetylcholine Receptor M3 (cluster #4 Of 5), Eukaryotic Eukaryotes 3000 0.37 Binding ≤ 10μM
ACM5-2-E Muscarinic Acetylcholine Receptor M5 (cluster #2 Of 4), Eukaryotic Eukaryotes 3000 0.37 Binding ≤ 10μM
ADA1A-1-E Alpha-1a Adrenergic Receptor (cluster #1 Of 3), Eukaryotic Eukaryotes 41 0.49 Binding ≤ 10μM
ADA1B-1-E Alpha-1b Adrenergic Receptor (cluster #1 Of 4), Eukaryotic Eukaryotes 41 0.49 Binding ≤ 10μM
ADA1D-1-E Alpha-1d Adrenergic Receptor (cluster #1 Of 3), Eukaryotic Eukaryotes 41 0.49 Binding ≤ 10μM
ADA2A-3-E Alpha-2a Adrenergic Receptor (cluster #3 Of 4), Eukaryotic Eukaryotes 41 0.49 Binding ≤ 10μM
ADA2B-1-E Alpha-2b Adrenergic Receptor (cluster #1 Of 4), Eukaryotic Eukaryotes 41 0.49 Binding ≤ 10μM
ADA2C-3-E Alpha-2c Adrenergic Receptor (cluster #3 Of 4), Eukaryotic Eukaryotes 41 0.49 Binding ≤ 10μM
ADCY1-1-E Brain Adenylate Cyclase 1 (cluster #1 Of 1), Eukaryotic Eukaryotes 60 0.48 Binding ≤ 10μM
ADCY2-2-E Adenylate Cyclase Type II (cluster #2 Of 2), Eukaryotic Eukaryotes 60 0.48 Binding ≤ 10μM
ADCY8-1-E Adenylate Cyclase Type VIII (cluster #1 Of 2), Eukaryotic Eukaryotes 60 0.48 Binding ≤ 10μM
ADRB1-1-E Beta-1 Adrenergic Receptor (cluster #1 Of 2), Eukaryotic Eukaryotes 41 0.49 Binding ≤ 10μM
ADRB2-1-E Beta-2 Adrenergic Receptor (cluster #1 Of 2), Eukaryotic Eukaryotes 41 0.49 Binding ≤ 10μM
ADRB3-1-E Beta-3 Adrenergic Receptor (cluster #1 Of 2), Eukaryotic Eukaryotes 41 0.49 Binding ≤ 10μM
DRD1-1-E Dopamine D1 Receptor (cluster #1 Of 4), Eukaryotic Eukaryotes 89 0.47 Binding ≤ 10μM
DRD3-1-E Dopamine D3 Receptor (cluster #1 Of 2), Eukaryotic Eukaryotes 206 0.45 Binding ≤ 10μM
DRD5-1-E Dopamine D5 Receptor (cluster #1 Of 1), Eukaryotic Eukaryotes 170 0.45 Binding ≤ 10μM
HRH1-2-E Histamine H1 Receptor (cluster #2 Of 2), Eukaryotic Eukaryotes 1 0.60 Binding ≤ 10μM
KCNH2-5-E HERG (cluster #5 Of 5), Eukaryotic Eukaryotes 5000 0.35 Binding ≤ 10μM
Q9WTR4-1-E Norepinephrine Transporter (cluster #1 Of 2), Eukaryotic Eukaryotes 2500 0.37 Binding ≤ 10μM
SC6A4-3-E Serotonin Transporter (cluster #3 Of 4), Eukaryotic Eukaryotes 8500 0.34 Binding ≤ 10μM
SCN1A-1-E Sodium Channel Protein Type I Alpha Subunit (cluster #1 Of 2), Eukaryotic Eukaryotes 10000 0.33 Binding ≤ 10μM
SCN2A-1-E Sodium Channel Protein Type II Alpha Subunit (cluster #1 Of 2), Eukaryotic Eukaryotes 10000 0.33 Binding ≤ 10μM
SCN3A-1-E Sodium Channel Protein Type III Alpha Subunit (cluster #1 Of 2), Eukaryotic Eukaryotes 10000 0.33 Binding ≤ 10μM
SCN8A-1-E Sodium Channel Protein Type VIII Alpha Subunit (cluster #1 Of 2), Eukaryotic Eukaryotes 10000 0.33 Binding ≤ 10μM
HRH2-1-E Histamine H2 Receptor (cluster #1 Of 2), Eukaryotic Eukaryotes 660 0.41 Functional ≤ 10μM
KCNH2-1-E HERG (cluster #1 Of 2), Eukaryotic Eukaryotes 10000 0.33 Functional ≤ 10μM
DRD2-15-E Dopamine D2 Receptor (cluster #15 Of 24), Eukaryotic Eukaryotes 196 0.45 Binding ≤ 10μM
Z104303-1-O Muscarinic Acetylcholine Receptor (cluster #1 Of 7), Other Other 300 0.43 Binding ≤ 10μM
Z50594-6-O Mus Musculus (cluster #6 Of 9), Other Other 5400 0.35 Functional ≤ 10μM
Z50597-12-O Rattus Norvegicus (cluster #12 Of 12), Other Other 61 0.48 Functional ≤ 10μM
ChEMBL Target Annotations
Uniprot Swissprot Description Affinity (nM) LE (kcal/mol/atom) Type
ADCY2_HUMAN Q08462 Adenylate Cyclase Type II, Human 53 0.49 Binding ≤ 1μM
ADCY8_HUMAN P40145 Adenylate Cyclase Type VIII, Human 53 0.49 Binding ≤ 1μM
ADA1A_RAT P43140 Alpha-1a Adrenergic Receptor, Rat 0.1 0.67 Binding ≤ 1μM
ADA1B_RAT P15823 Alpha-1b Adrenergic Receptor, Rat 41 0.49 Binding ≤ 1μM
ADA1D_RAT P23944 Alpha-1d Adrenergic Receptor, Rat 41 0.49 Binding ≤ 1μM
ADA2A_RAT P22909 Alpha-2a Adrenergic Receptor, Rat 41 0.49 Binding ≤ 1μM
ADA2B_RAT P19328 Alpha-2b Adrenergic Receptor, Rat 41 0.49 Binding ≤ 1μM
ADA2C_RAT P22086 Alpha-2c Adrenergic Receptor, Rat 41 0.49 Binding ≤ 1μM
ADRB1_RAT P18090 Beta-1 Adrenergic Receptor, Rat 41 0.49 Binding ≤ 1μM
ADRB2_RAT P10608 Beta-2 Adrenergic Receptor, Rat 41 0.49 Binding ≤ 1μM
ADRB3_RAT P26255 Beta-3 Adrenergic Receptor, Rat 41 0.49 Binding ≤ 1μM
ADCY1_HUMAN Q08828 Brain Adenylate Cyclase 1, Human 53 0.49 Binding ≤ 1μM
DRD1_HUMAN P21728 Dopamine D1 Receptor, Human 89 0.47 Binding ≤ 1μM
DRD2_HUMAN P14416 Dopamine D2 Receptor, Human 196 0.45 Binding ≤ 1μM
DRD3_HUMAN P35462 Dopamine D3 Receptor, Human 206 0.45 Binding ≤ 1μM
DRD5_HUMAN P21918 Dopamine D5 Receptor, Human 170 0.45 Binding ≤ 1μM
HRH1_RAT P31390 Histamine H1 Receptor, Rat 0.1 0.67 Binding ≤ 1μM
HRH1_HUMAN P35367 Histamine H1 Receptor, Human 1.12 0.60 Binding ≤ 1μM
Z104303 Z104303 Muscarinic Acetylcholine Receptor 300 0.43 Binding ≤ 1μM
5HT1A_RAT P19327 Serotonin 1a (5-HT1a) Receptor, Rat 44 0.49 Binding ≤ 1μM
5HT1B_RAT P28564 Serotonin 1b (5-HT1b) Receptor, Rat 44 0.49 Binding ≤ 1μM
5HT1D_RAT P28565 Serotonin 1d (5-HT1d) Receptor, Rat 44 0.49 Binding ≤ 1μM
5HT1F_RAT P30940 Serotonin 1f (5-HT1f) Receptor, Rat 44 0.49 Binding ≤ 1μM
5HT2A_RAT P14842 Serotonin 2a (5-HT2a) Receptor, Rat 44 0.49 Binding ≤ 1μM
5HT2B_RAT P30994 Serotonin 2b (5-HT2b) Receptor, Rat 44 0.49 Binding ≤ 1μM
5HT2C_RAT P08909 Serotonin 2c (5-HT2c) Receptor, Rat 44 0.49 Binding ≤ 1μM
5HT4R_RAT Q62758 Serotonin 4 (5-HT4) Receptor, Rat 44 0.49 Binding ≤ 1μM
5HT5A_RAT P35364 Serotonin 5a (5-HT5a) Receptor, Rat 44 0.49 Binding ≤ 1μM
5HT5B_RAT P35365 Serotonin 5b (5-HT5b) Receptor, Rat 44 0.49 Binding ≤ 1μM
5HT6R_RAT P31388 Serotonin 6 (5-HT6) Receptor, Rat 44 0.49 Binding ≤ 1μM
5HT7R_RAT P32305 Serotonin 7 (5-HT7) Receptor, Rat 44 0.49 Binding ≤ 1μM
ADCY2_HUMAN Q08462 Adenylate Cyclase Type II, Human 53 0.49 Binding ≤ 10μM
ADCY8_HUMAN P40145 Adenylate Cyclase Type VIII, Human 53 0.49 Binding ≤ 10μM
ADA1A_RAT P43140 Alpha-1a Adrenergic Receptor, Rat 0.1 0.67 Binding ≤ 10μM
ADA1B_RAT P15823 Alpha-1b Adrenergic Receptor, Rat 41 0.49 Binding ≤ 10μM
ADA1D_RAT P23944 Alpha-1d Adrenergic Receptor, Rat 41 0.49 Binding ≤ 10μM
ADA2A_RAT P22909 Alpha-2a Adrenergic Receptor, Rat 41 0.49 Binding ≤ 10μM
ADA2B_RAT P19328 Alpha-2b Adrenergic Receptor, Rat 41 0.49 Binding ≤ 10μM
ADA2C_RAT P22086 Alpha-2c Adrenergic Receptor, Rat 41 0.49 Binding ≤ 10μM
ADRB1_RAT P18090 Beta-1 Adrenergic Receptor, Rat 41 0.49 Binding ≤ 10μM
ADRB2_RAT P10608 Beta-2 Adrenergic Receptor, Rat 41 0.49 Binding ≤ 10μM
ADRB3_RAT P26255 Beta-3 Adrenergic Receptor, Rat 41 0.49 Binding ≤ 10μM
ADCY1_HUMAN Q08828 Brain Adenylate Cyclase 1, Human 53 0.49 Binding ≤ 10μM
DRD1_HUMAN P21728 Dopamine D1 Receptor, Human 89 0.47 Binding ≤ 10μM
DRD2_HUMAN P14416 Dopamine D2 Receptor, Human 196 0.45 Binding ≤ 10μM
DRD3_HUMAN P35462 Dopamine D3 Receptor, Human 206 0.45 Binding ≤ 10μM
DRD5_HUMAN P21918 Dopamine D5 Receptor, Human 170 0.45 Binding ≤ 10μM
KCNH2_HUMAN Q12809 HERG, Human 10000 0.33 Binding ≤ 10μM
HRH1_HUMAN P35367 Histamine H1 Receptor, Human 1.12 0.60 Binding ≤ 10μM
HRH1_RAT P31390 Histamine H1 Receptor, Rat 0.1 0.67 Binding ≤ 10μM
Z104303 Z104303 Muscarinic Acetylcholine Receptor 300 0.43 Binding ≤ 10μM
ACM1_RAT P08482 Muscarinic Acetylcholine Receptor M1, Rat 3000 0.37 Binding ≤ 10μM
ACM2_RAT P10980 Muscarinic Acetylcholine Receptor M2, Rat 3000 0.37 Binding ≤ 10μM
ACM3_RAT P08483 Muscarinic Acetylcholine Receptor M3, Rat 3000 0.37 Binding ≤ 10μM
ACM5_RAT P08911 Muscarinic Acetylcholine Receptor M5, Rat 3000 0.37 Binding ≤ 10μM
Q9WTR4_RAT Q9WTR4 Norepinephrine Transporter, Rat 2500 0.37 Binding ≤ 10μM
5HT1A_RAT P19327 Serotonin 1a (5-HT1a) Receptor, Rat 44 0.49 Binding ≤ 10μM
5HT1B_RAT P28564 Serotonin 1b (5-HT1b) Receptor, Rat 44 0.49 Binding ≤ 10μM
5HT1D_RAT P28565 Serotonin 1d (5-HT1d) Receptor, Rat 44 0.49 Binding ≤ 10μM
5HT1F_RAT P30940 Serotonin 1f (5-HT1f) Receptor, Rat 44 0.49 Binding ≤ 10μM
5HT2A_RAT P14842 Serotonin 2a (5-HT2a) Receptor, Rat 44 0.49 Binding ≤ 10μM
5HT2B_RAT P30994 Serotonin 2b (5-HT2b) Receptor, Rat 44 0.49 Binding ≤ 10μM
5HT2C_RAT P08909 Serotonin 2c (5-HT2c) Receptor, Rat 44 0.49 Binding ≤ 10μM
5HT4R_RAT Q62758 Serotonin 4 (5-HT4) Receptor, Rat 44 0.49 Binding ≤ 10μM
5HT5A_RAT P35364 Serotonin 5a (5-HT5a) Receptor, Rat 44 0.49 Binding ≤ 10μM
5HT5B_RAT P35365 Serotonin 5b (5-HT5b) Receptor, Rat 44 0.49 Binding ≤ 10μM
5HT6R_RAT P31388 Serotonin 6 (5-HT6) Receptor, Rat 44 0.49 Binding ≤ 10μM
5HT7R_RAT P32305 Serotonin 7 (5-HT7) Receptor, Rat 44 0.49 Binding ≤ 10μM
SC6A4_RAT P31652 Serotonin Transporter, Rat 8500 0.34 Binding ≤ 10μM
SCN1A_HUMAN P35498 Sodium Channel Protein Type I Alpha Subunit, Human 10000 0.33 Binding ≤ 10μM
SCN2A_HUMAN Q99250 Sodium Channel Protein Type II Alpha Subunit, Human 10000 0.33 Binding ≤ 10μM
SCN3A_HUMAN Q9NY46 Sodium Channel Protein Type III Alpha Subunit, Human 10000 0.33 Binding ≤ 10μM
SCN8A_HUMAN Q9UQD0 Sodium Channel Protein Type VIII Alpha Subunit, Human 10000 0.33 Binding ≤ 10μM
KCNH2_HUMAN Q12809 HERG, Human 10000 0.33 Functional ≤ 10μM
HRH2_HUMAN P25021 Histamine H2 Receptor, Human 660 0.41 Functional ≤ 10μM
Z50594 Z50594 Mus Musculus 2900 0.37 Functional ≤ 10μM
Z50597 Z50597 Rattus Norvegicus 2000 0.38 Functional ≤ 10μM

Reactome Annotations from Targets (via Uniprot)

Description Species
Acetylcholine regulates insulin secretion
Adenylate cyclase activating pathway
Adenylate cyclase inhibitory pathway
Adrenaline signalling through Alpha-2 adrenergic receptor
Adrenaline,noradrenaline inhibits insulin secretion
Adrenoceptors
CREB phosphorylation through the activation of Adenylate Cyclase
Dopamine receptors
G alpha (12/13) signalling events
G alpha (i) signalling events
G alpha (q) signalling events
G alpha (s) signalling events
G alpha (z) signalling events
Glucagon signaling in metabolic regulation
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Histamine receptors
Interaction between L1 and Ankyrins
Muscarinic acetylcholine receptors
PKA activation
PKA activation in glucagon signalling
Serotonin receptors
Vasopressin regulates renal water homeostasis via Aquaporins
Voltage gated Potassium channels

Analogs ( Draw Identity 99% 90% 80% 70% )