| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| October 18th, 2005 | 39 | No |
Popular Name: Doxorubicin Doxorubicin
Find On: PubMed — Wikipedia — Google
CAS Numbers: 23214-92-8 , 25316-40-9
23214-92-8; ADR; Adriblastina (TN); D03899; Doxorubicin (USAN/INN)
23214-92-8; Adriamycin; C01661; Doxorubicin
25316-40-9; Doxorubicin hydrochloride; Prestwick_188
CHEBI:42031; CHEBI:2496; CHEBI:22270
CPD000058570; DOXORUBICIN HYDROCHLORIDE
CPD000058570; DOXORUBICIN HYDROCHLORIDE; SAM001246768
doxorubicin; doxorubicin cation
doxorubicin; doxorubicine; doxorubicinum
Doxorubicina [INN-Spanish];Doxorubicine [INN-French];Doxorubicinum [INN-Latin]
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 0.57 | -0.88 | -58.15 | 8 | 12 | 1 | 208 | 544.533 | 5 | ↓ |
| Note Type | Comments | Provided By |
|---|---|---|
| ALOGPS_SOLUBILITY | 1.18e+00 g/l | DrugBank-approved |
| UniProt Database Links | ABCB5_HUMAN; ABCG2_HUMAN; AEN_HUMAN; AK1A1_HUMAN; ANKR1_PIG; ANKR1_RABIT; ANKR1_RAT; CBR1_BOVIN; CBR1_HUMAN; CBR1_MACFA; CBR1_MOUSE; CBR1_PIG; CBR1_PONAB; CBR1_RABIT; CBR1_RAT; CC85B_HUMAN; CCNG1_RAT; CD2A2_MOUSE; CIP4_HUMAN; CSAG2_HUMAN; DNRF_STRC0; DNRU | ChEBI |
| UniProt Database Links | ABCB5_HUMAN; ABCG2_HUMAN; AK1A1_HUMAN; ANKR1_PIG; ANKR1_RABIT; ANKR1_RAT; CBR1_BOVIN; CBR1_HUMAN; CBR1_MACFA; CBR1_MOUSE; CBR1_PIG; CBR1_PONAB; CBR1_RABIT; CBR1_RAT; CC85B_HUMAN; CCNG1_RAT; CD2A2_MOUSE; CSAG2_HUMAN; DNRF_STRC0; DNRU_STRPE; DNRU_STRS5; DNR | ChEBI |
| therap | antineoplastic | MicroSource Spectrum |
| biological_use | Antineoplastic antibiotic | IBScreen Bioactives IBScreen Bioactives |
| PUBCHEM_PATENT_ID | EP0000667A1; EP0002046A2; EP0004467A2; EP0007400A1; EP0007597A1; EP0007895A1; EP0012159A1; EP0014425A1; EP0014853A1; EP0016157A1; EP0017469A1; EP0022515A1; EP0022574A1; EP0023663A2; EP0024727A1; EP0025705A1; EP0026849A1; EP0030255A2; EP0031237A1; EP003172 | IBM Patent Data |
| Patent Database Links | EP0812830; EP1110552; EP1184037; EP1243276; EP1331005; EP1348707; EP1386922; EP1422225; EP1438962; EP1475094; EP1493445; EP1498127; EP1510215; EP1514560; EP1531181; EP1537858; EP1537861; EP1537871; EP1538164; EP1541142; EP1543839; EP1552841; EP1574499; EP | ChEBI |
| mechanism | Forms complexes with DNA by intercalation between base pairs | IBScreen Bioactives IBScreen Bioactives |
| Therapy | Inhibitors: topoisomerase II inhibitor, induces apoptosis | SMDC Iconix |
| mechanism | Inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the ligation-religation reaction that topoisomerase II catalyzes | IBScreen Bioactives |
| mechanism | May also inhibit polymerase activity, affect regulation of gene expression, and produce free radical damage to DNA | IBScreen Bioactives |
| PUBCHEM_SUBSTANCE_COMMENT | NCC_SAMPLE_SUPPLIER : Sequoia Research Products Ltd.; NCC_SUPPLIER_STRUCTURE_ID : SRP04600d; 1 hydrogen chloride | NIH Clinical Collection via PubChem |
| biological_use | Possesses an antitumor effect against a wide spectrum of tumors | IBScreen Bioactives |
| PUBCHEM_SUBSTANCE_COMMENT | SAMPLE_SUPPLIER: Sequoia Research Products Ltd.; SUPPLIER_STRUCTURE_ID: SRP04600d; SALT: 1 hydrogen chloride | NIH Clinical Collection via PubChem |
| biological_use | Shows anti-HIV activity | IBScreen Bioactives |
| biological_use | Used in the treatment of ovarian cancer and AIDS related Kaposi sarcoma | IBScreen Bioactives |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| AURKA-1-E | Serine/threonine-protein Kinase Aurora-A (cluster #1 Of 3), Eukaryotic | Eukaryotes | 40 | 0.27 | Binding ≤ 10μM |
| MMP2-2-E | 72 KDa Type IV Collagenase (cluster #2 Of 3), Eukaryotic | Eukaryotes | 1100 | 0.21 | Binding ≤ 10μM |
| TOP2A-1-E | DNA Topoisomerase II Alpha (cluster #1 Of 2), Eukaryotic | Eukaryotes | 1000 | 0.22 | Binding ≤ 10μM |
| TOP1-1-E | DNA Topoisomerase I (cluster #1 Of 1), Eukaryotic | Eukaryotes | 22 | 0.27 | Functional ≤ 10μM |
| TOP2A-1-E | DNA Topoisomerase II Alpha (cluster #1 Of 1), Eukaryotic | Eukaryotes | 22 | 0.27 | Functional ≤ 10μM |
| TOP2B-1-E | DNA Topoisomerase II Beta (cluster #1 Of 1), Eukaryotic | Eukaryotes | 22 | 0.27 | Functional ≤ 10μM |
| Z50643-2-O | Hepatitis C Virus (cluster #2 Of 2), Other | Other | 2600 | 0.20 | Binding ≤ 10μM |
| Z103196-1-O | 22RV1 (cluster #1 Of 2), Other | Other | 1300 | 0.21 | Functional ≤ 10μM |
| Z103203-1-O | A375 (cluster #1 Of 3), Other | Other | 130 | 0.25 | Functional ≤ 10μM |
| Z103205-1-O | A431 (cluster #1 Of 4), Other | Other | 370 | 0.23 | Functional ≤ 10μM |
| Z103219-1-O | Ca9-22 (cluster #1 Of 1), Other | Other | 1300 | 0.21 | Functional ≤ 10μM |
| Z50347-3-O | Saccharomyces Cerevisiae (cluster #3 Of 3), Other | Other | 10000 | 0.18 | Functional ≤ 10μM |
| Z50587-4-O | Homo Sapiens (cluster #4 Of 9), Other | Other | 100 | 0.25 | Functional ≤ 10μM |
| Z50643-2-O | Hepatitis C Virus (cluster #2 Of 5), Other | Other | 300 | 0.23 | Functional ≤ 10μM |
| Z80008-1-O | 5637 (Epithelial Bladder Carcinoma Cells) (cluster #1 Of 3), Other | Other | 20 | 0.28 | Functional ≤ 10μM |
| Z80017-1-O | A2780cisR (Cisplatin-resistant Ovarian Carcinoma Cells) (cluster #1 Of 2), Other | Other | 6 | 0.30 | Functional ≤ 10μM |
| Z80018-2-O | A-375 (Malignant Melanoma Cells) (cluster #2 Of 4), Other | Other | 70 | 0.26 | Functional ≤ 10μM |
| Z80021-3-O | A498 (Renal Carcinoma Cells) (cluster #3 Of 5), Other | Other | 53 | 0.26 | Functional ≤ 10μM |
| Z80025-1-O | ACHN (Renal Adenocarcinoma Cells) (cluster #1 Of 3), Other | Other | 700 | 0.22 | Functional ≤ 10μM |
| Z80026-1-O | AGS (Gastric Adenocarcinoma Cells) (cluster #1 Of 2), Other | Other | 310 | 0.23 | Functional ≤ 10μM |
| Z80035-1-O | B16 (Melanoma Cells) (cluster #1 Of 7), Other | Other | 8 | 0.29 | Functional ≤ 10μM |
| Z80039-1-O | BGC-823 (Stomach Adenocarcinoma Cells) (cluster #1 Of 2), Other | Other | 1000 | 0.22 | Functional ≤ 10μM |
| Z80052-1-O | C8166 (Leukemic T-cells) (cluster #1 Of 3), Other | Other | 50 | 0.26 | Functional ≤ 10μM |
| Z80054-1-O | Caco-2 (Colon Adenocarcinoma Cells) (cluster #1 Of 4), Other | Other | 6700 | 0.19 | Functional ≤ 10μM |
| Z80064-1-O | CCRF-CEM (T-cell Leukemia) (cluster #1 Of 9), Other | Other | 90 | 0.25 | Functional ≤ 10μM |
| Z80068-1-O | CCRF-SB (Lymphoblastic Leukemia Cells) (cluster #1 Of 5), Other | Other | 50 | 0.26 | Functional ≤ 10μM |
| Z80088-1-O | CHO (Ovarian Cells) (cluster #1 Of 4), Other | Other | 6000 | 0.19 | Functional ≤ 10μM |
| Z80092-1-O | CHO-K1 (Ovarian Cells) (cluster #1 Of 2), Other | Other | 400 | 0.23 | Functional ≤ 10μM |
| Z80105-2-O | COR-L23 (Lung Carcinoma Cells) (cluster #2 Of 2), Other | Other | 319 | 0.23 | Functional ≤ 10μM |
| Z80114-1-O | Daudi (Burkitts Lymphoma Cells) (cluster #1 Of 4), Other | Other | 300 | 0.23 | Functional ≤ 10μM |
| Z80125-1-O | DU-145 (Prostate Carcinoma) (cluster #1 Of 9), Other | Other | 2540 | 0.20 | Functional ≤ 10μM |
| Z80125-1-O | DU-145 (Prostate Carcinoma) (cluster #1 Of 9), Other | Other | 6240 | 0.19 | Functional ≤ 10μM |
| Z80126-2-O | DuPro (cluster #2 Of 2), Other | Other | 1800 | 0.21 | Functional ≤ 10μM |
| Z80138-1-O | G-361 (Melanoma Cells) (cluster #1 Of 1), Other | Other | 90 | 0.25 | Functional ≤ 10μM |
| Z80145-3-O | H69 (cluster #3 Of 4), Other | Other | 870 | 0.22 | Functional ≤ 10μM |
| Z80156-2-O | HL-60 (Promyeloblast Leukemia Cells) (cluster #2 Of 12), Other | Other | 920 | 0.22 | Functional ≤ 10μM |
| Z80156-2-O | HL-60 (Promyeloblast Leukemia Cells) (cluster #2 Of 12), Other | Other | 940 | 0.22 | Functional ≤ 10μM |
| Z80164-1-O | HT-1080 (Fibrosarcoma Cells) (cluster #1 Of 6), Other | Other | 4700 | 0.19 | Functional ≤ 10μM |
| Z80164-1-O | HT-1080 (Fibrosarcoma Cells) (cluster #1 Of 6), Other | Other | 9320 | 0.18 | Functional ≤ 10μM |
| Z80166-1-O | HT-29 (Colon Adenocarcinoma Cells) (cluster #1 Of 12), Other | Other | 92 | 0.25 | Functional ≤ 10μM |
| Z80166-1-O | HT-29 (Colon Adenocarcinoma Cells) (cluster #1 Of 12), Other | Other | 950 | 0.22 | Functional ≤ 10μM |
| Z80175-1-O | IMR-32 (Neuroblastoma Cells) (cluster #1 Of 2), Other | Other | 10 | 0.29 | Functional ≤ 10μM |
| Z80186-1-O | K562 (Erythroleukemia Cells) (cluster #1 Of 11), Other | Other | 90 | 0.25 | Functional ≤ 10μM |
| Z80186-1-O | K562 (Erythroleukemia Cells) (cluster #1 Of 11), Other | Other | 430 | 0.23 | Functional ≤ 10μM |
| Z80188-1-O | KB 3-1 (Cervical Epithelial Carcinoma Cells) (cluster #1 Of 2), Other | Other | 21 | 0.28 | Functional ≤ 10μM |
| Z80193-2-O | L1210 (Lymphocytic Leukemia Cells) (cluster #2 Of 12), Other | Other | 900 | 0.22 | Functional ≤ 10μM |
| Z80211-1-O | LoVo (Colon Adenocarcinoma Cells) (cluster #1 Of 5), Other | Other | 200 | 0.24 | Functional ≤ 10μM |
| Z80211-1-O | LoVo (Colon Adenocarcinoma Cells) (cluster #1 Of 5), Other | Other | 9700 | 0.18 | Functional ≤ 10μM |
| Z80214-2-O | M14 (Melanoma Cells) (cluster #2 Of 3), Other | Other | 820 | 0.22 | Functional ≤ 10μM |
| Z80224-1-O | MCF7 (Breast Carcinoma Cells) (cluster #1 Of 14), Other | Other | 80 | 0.25 | Functional ≤ 10μM |
| Z80224-1-O | MCF7 (Breast Carcinoma Cells) (cluster #1 Of 14), Other | Other | 920 | 0.22 | Functional ≤ 10μM |
| Z80227-1-O | MCF7-ADR (Breast Carcinoma Cells) (cluster #1 Of 2), Other | Other | 6700 | 0.19 | Functional ≤ 10μM |
| Z80240-1-O | MDA-MB-361 (cluster #1 Of 1), Other | Other | 33 | 0.27 | Functional ≤ 10μM |
| Z80243-1-O | MDA-MB-453 (Breast Adenocarcinoma Cells) (cluster #1 Of 1), Other | Other | 120 | 0.25 | Functional ≤ 10μM |
| Z80244-4-O | MDA-MB-468 (Breast Adenocarcinoma) (cluster #4 Of 7), Other | Other | 7 | 0.29 | Functional ≤ 10μM |
| Z80254-1-O | MES-SA (Uterine Sarcoma Cells) (cluster #1 Of 2), Other | Other | 10 | 0.29 | Functional ≤ 10μM |
| Z80255-2-O | MES-SA/DxS (Uterine Sarcoma Cells) (cluster #2 Of 2), Other | Other | 704 | 0.22 | Functional ≤ 10μM |
| Z80267-1-O | MKN-1 (cluster #1 Of 1), Other | Other | 640 | 0.22 | Functional ≤ 10μM |
| Z80269-1-O | MKN-45 (Gastric Adenocarcinoma Cells) (cluster #1 Of 3), Other | Other | 3130 | 0.20 | Functional ≤ 10μM |
| Z80285-2-O | MOLT-4 (Acute T-lymphoblastic Leukemia Cells) (cluster #2 Of 4), Other | Other | 50 | 0.26 | Functional ≤ 10μM |
| Z80291-1-O | MRC5 (Embryonic Lung Fibroblast Cells) (cluster #1 Of 3), Other | Other | 100 | 0.25 | Functional ≤ 10μM |
| Z80295-6-O | MT4 (Lymphocytes) (cluster #6 Of 8), Other | Other | 50 | 0.26 | Functional ≤ 10μM |
| Z80322-2-O | NCI-H358 (Lung Carcinama Cells) (cluster #2 Of 2), Other | Other | 620 | 0.22 | Functional ≤ 10μM |
| Z80330-1-O | NCI-N87 (cluster #1 Of 1), Other | Other | 420 | 0.23 | Functional ≤ 10μM |
| Z80354-4-O | OVCAR-3 (Ovarian Adenocarcinoma Cells) (cluster #4 Of 4), Other | Other | 35 | 0.27 | Functional ≤ 10μM |
| Z80362-1-O | P388 (Lymphoma Cells) (cluster #1 Of 8), Other | Other | 17 | 0.28 | Functional ≤ 10μM |
| Z80362-1-O | P388 (Lymphoma Cells) (cluster #1 Of 8), Other | Other | 830 | 0.22 | Functional ≤ 10μM |
| Z80364-1-O | P388/ADR (Lymphoma Cells) (cluster #1 Of 1), Other | Other | 90 | 0.25 | Functional ≤ 10μM |
| Z80367-1-O | P388/S (cluster #1 Of 1), Other | Other | 13 | 0.28 | Functional ≤ 10μM |
| Z80389-1-O | PC-14 (cluster #1 Of 1), Other | Other | 290 | 0.23 | Functional ≤ 10μM |
| Z80390-1-O | PC-3 (Prostate Carcinoma Cells) (cluster #1 Of 10), Other | Other | 680 | 0.22 | Functional ≤ 10μM |
| Z80390-1-O | PC-3 (Prostate Carcinoma Cells) (cluster #1 Of 10), Other | Other | 912 | 0.22 | Functional ≤ 10μM |
| Z80414-1-O | Raji (B-lymphoblastic Cells) (cluster #1 Of 3), Other | Other | 30 | 0.27 | Functional ≤ 10μM |
| Z80433-1-O | RPMI-8226 (Multiple Myeloma Cells) (cluster #1 Of 3), Other | Other | 560 | 0.22 | Functional ≤ 10μM |
| Z80441-1-O | RXF 944 (cluster #1 Of 1), Other | Other | 60 | 0.26 | Functional ≤ 10μM |
| Z80466-1-O | SF268 (cluster #1 Of 4), Other | Other | 600 | 0.22 | Functional ≤ 10μM |
| Z80468-1-O | SF-295 (Glioblastoma Cells) (cluster #1 Of 2), Other | Other | 35 | 0.27 | Functional ≤ 10μM |
| Z80472-1-O | SiHa (Cervical Squamous Cell Carcinoma) (cluster #1 Of 2), Other | Other | 500 | 0.23 | Functional ≤ 10μM |
| Z80475-1-O | SK-BR-3 (Breast Adenocarcinoma) (cluster #1 Of 3), Other | Other | 20 | 0.28 | Functional ≤ 10μM |
| Z80477-1-O | SK_HEP1 (Hepatoma Cells) (cluster #1 Of 1), Other | Other | 100 | 0.25 | Functional ≤ 10μM |
| Z80479-1-O | SK-MEL (Melanoma Cells) (cluster #1 Of 1), Other | Other | 1730 | 0.21 | Functional ≤ 10μM |
| Z80481-1-O | SK-MEL-1 (Metastatic Melanoma Cells) (cluster #1 Of 1), Other | Other | 3092 | 0.20 | Functional ≤ 10μM |
| Z80482-3-O | SK-MEL-2 (Melanoma Cells) (cluster #3 Of 4), Other | Other | 97 | 0.25 | Functional ≤ 10μM |
| Z80485-1-O | SK-MEL-28 (Melanoma Cells) (cluster #1 Of 6), Other | Other | 600 | 0.22 | Functional ≤ 10μM |
| Z80490-3-O | SK-MES-1 (cluster #3 Of 4), Other | Other | 30 | 0.27 | Functional ≤ 10μM |
| Z80491-2-O | SK-N-MC (Neuroepithelioma Cells) (cluster #2 Of 4), Other | Other | 120 | 0.25 | Functional ≤ 10μM |
| Z80492-1-O | SK-N-SH (Neuroblastoma Cells) (cluster #1 Of 2), Other | Other | 1100 | 0.21 | Functional ≤ 10μM |
| Z80493-1-O | SK-OV-3 (Ovarian Carcinoma Cells) (cluster #1 Of 6), Other | Other | 800 | 0.22 | Functional ≤ 10μM |
| Z80495-1-O | SK-VLB (cluster #1 Of 1), Other | Other | 6540 | 0.19 | Functional ≤ 10μM |
| Z80503-1-O | SNU1 (cluster #1 Of 2), Other | Other | 4000 | 0.19 | Functional ≤ 10μM |
| Z80509-1-O | SNU-638 (Gastric Carcinoma Cells) (cluster #1 Of 1), Other | Other | 690 | 0.22 | Functional ≤ 10μM |
| Z80526-1-O | SW480 (Colon Adenocarcinoma Cells) (cluster #1 Of 6), Other | Other | 60 | 0.26 | Functional ≤ 10μM |
| Z80532-1-O | T-24 (Bladder Carcinoma Cells) (cluster #1 Of 6), Other | Other | 640 | 0.22 | Functional ≤ 10μM |
| Z80559-1-O | U251 (cluster #1 Of 3), Other | Other | 90 | 0.25 | Functional ≤ 10μM |
| Z80560-1-O | U-251 (Glioma Cells) (cluster #1 Of 3), Other | Other | 90 | 0.25 | Functional ≤ 10μM |
| Z80563-1-O | U-373 MG ( Glioblastoma Cells) (cluster #1 Of 1), Other | Other | 10 | 0.29 | Functional ≤ 10μM |
| Z80565-1-O | U-87 MG (Glioblastoma Cells) (cluster #1 Of 2), Other | Other | 60 | 0.26 | Functional ≤ 10μM |
| Z80574-2-O | UMUC3 (cluster #2 Of 2), Other | Other | 9 | 0.29 | Functional ≤ 10μM |
| Z80581-1-O | VA13 (cluster #1 Of 1), Other | Other | 400 | 0.23 | Functional ≤ 10μM |
| Z80581-1-O | VA13 (cluster #1 Of 1), Other | Other | 699 | 0.22 | Functional ≤ 10μM |
| Z80583-1-O | Vero (Kidney Cells) (cluster #1 Of 7), Other | Other | 5000 | 0.19 | Functional ≤ 10μM |
| Z80595-1-O | WIL2-NS (Lymphoblastoid Cells) (cluster #1 Of 2), Other | Other | 200 | 0.24 | Functional ≤ 10μM |
| Z80600-2-O | XF498 (Glioma Cells) (cluster #2 Of 2), Other | Other | 44 | 0.26 | Functional ≤ 10μM |
| Z80608-1-O | ZR-75-1 (Breast Carcinoma Cells) (cluster #1 Of 4), Other | Other | 9 | 0.29 | Functional ≤ 10μM |
| Z80640-1-O | 786-0 (Renal Carcinoma Cells) (cluster #1 Of 1), Other | Other | 3100 | 0.20 | Functional ≤ 10μM |
| Z80661-1-O | A704 (Renal Carcinoma Cells) (cluster #1 Of 1), Other | Other | 2000 | 0.20 | Functional ≤ 10μM |
| Z80682-1-O | A549 (Lung Carcinoma Cells) (cluster #1 Of 11), Other | Other | 540 | 0.22 | Functional ≤ 10μM |
| Z80682-1-O | A549 (Lung Carcinoma Cells) (cluster #1 Of 11), Other | Other | 970 | 0.22 | Functional ≤ 10μM |
| Z80697-1-O | Bel-7402 (Hepatoma Cells) (cluster #1 Of 3), Other | Other | 1000 | 0.22 | Functional ≤ 10μM |
| Z80712-2-O | T47D (Breast Carcinoma Cells) (cluster #2 Of 7), Other | Other | 72 | 0.26 | Functional ≤ 10μM |
| Z80726-1-O | TRAMP-C1A (Prostate Carcinoma Cells) (cluster #1 Of 1), Other | Other | 76 | 0.26 | Functional ≤ 10μM |
| Z80730-1-O | C2D Cell Line (cluster #1 Of 1), Other | Other | 47 | 0.26 | Functional ≤ 10μM |
| Z80731-1-O | C2G Cell Line (cluster #1 Of 1), Other | Other | 29 | 0.27 | Functional ≤ 10μM |
| Z80732-1-O | TRAMP-C2H (Prostate Carcinoma Cells) (cluster #1 Of 1), Other | Other | 30 | 0.27 | Functional ≤ 10μM |
| Z80735-1-O | C38 (Colon Carcinoma) (cluster #1 Of 1), Other | Other | 10 | 0.29 | Functional ≤ 10μM |
| Z80768-1-O | CH1 (Ovarian Carcinoma Cells) (cluster #1 Of 1), Other | Other | 6 | 0.30 | Functional ≤ 10μM |
| Z80784-1-O | Col2 (Colon Carcinoma Cells) (cluster #1 Of 2), Other | Other | 520 | 0.23 | Functional ≤ 10μM |
| Z80801-2-O | CRL-7065 Cell Line (cluster #2 Of 2), Other | Other | 500 | 0.23 | Functional ≤ 10μM |
| Z80819-1-O | J774.2 (cluster #1 Of 1), Other | Other | 368 | 0.23 | Functional ≤ 10μM |
| Z80846-1-O | F460pv8/eto Cell Line (cluster #1 Of 2), Other | Other | 20 | 0.28 | Functional ≤ 10μM |
| Z80852-1-O | A-431 (Epidermoid Carcinoma Cells) (cluster #1 Of 3), Other | Other | 50 | 0.26 | Functional ≤ 10μM |
| Z80874-1-O | CEM (T-cell Leukemia) (cluster #1 Of 7), Other | Other | 60 | 0.26 | Functional ≤ 10μM |
| Z80887-1-O | H2981 Cell Line (cluster #1 Of 1), Other | Other | 700 | 0.22 | Functional ≤ 10μM |
| Z80889-1-O | NCI-H322M (Non-small Cell Lung Carcinoma Cells) (cluster #1 Of 3), Other | Other | 30 | 0.27 | Functional ≤ 10μM |
| Z80896-1-O | NCI-H69 (Small Cell Lung Carcinoma Cells) (cluster #1 Of 1), Other | Other | 27 | 0.27 | Functional ≤ 10μM |
| Z80928-1-O | HCT-116 (Colon Carcinoma Cells) (cluster #1 Of 9), Other | Other | 90 | 0.25 | Functional ≤ 10μM |
| Z80928-1-O | HCT-116 (Colon Carcinoma Cells) (cluster #1 Of 9), Other | Other | 6810 | 0.19 | Functional ≤ 10μM |
| Z80936-1-O | HEK293 (Embryonic Kidney Fibroblasts) (cluster #1 Of 4), Other | Other | 900 | 0.22 | Functional ≤ 10μM |
| Z80943-1-O | HEL 299 (cluster #1 Of 1), Other | Other | 1700 | 0.21 | Functional ≤ 10μM |
| Z80945-1-O | HEp-2 (Laryngeal Carcinoma Cells) (cluster #1 Of 4), Other | Other | 59 | 0.26 | Functional ≤ 10μM |
| Z81005-1-O | HTB-54 Cell Line (cluster #1 Of 1), Other | Other | 1100 | 0.21 | Functional ≤ 10μM |
| Z81006-1-O | Human Breast 401NL Tumor Cell Line (cluster #1 Of 1), Other | Other | 10 | 0.29 | Functional ≤ 10μM |
| Z81017-1-O | WiDr (Colon Adenocarcinoma Cells) (cluster #1 Of 5), Other | Other | 620 | 0.22 | Functional ≤ 10μM |
| Z81020-3-O | HepG2 (Hepatoblastoma Cells) (cluster #3 Of 8), Other | Other | 954 | 0.22 | Functional ≤ 10μM |
| Z81020-3-O | HepG2 (Hepatoblastoma Cells) (cluster #3 Of 8), Other | Other | 1290 | 0.21 | Functional ≤ 10μM |
| Z81024-1-O | NCI-H460 (Non-small Cell Lung Carcinoma) (cluster #1 Of 8), Other | Other | 660 | 0.22 | Functional ≤ 10μM |
| Z81025-1-O | Human Lung LXF 529L Tumor Cell Line (cluster #1 Of 1), Other | Other | 30 | 0.27 | Functional ≤ 10μM |
| Z81026-1-O | Human Lung LXF 629L Tumor Cell Line (cluster #1 Of 1), Other | Other | 70 | 0.26 | Functional ≤ 10μM |
| Z81028-1-O | Human Melanoma Cell Line (cluster #1 Of 1), Other | Other | 280 | 0.24 | Functional ≤ 10μM |
| Z81034-2-O | A2780 (Ovarian Carcinoma Cells) (cluster #2 Of 10), Other | Other | 10 | 0.29 | Functional ≤ 10μM |
| Z81043-1-O | N592 (cluster #1 Of 2), Other | Other | 40 | 0.27 | Functional ≤ 10μM |
| Z81054-1-O | SF-268 (Glioblastoma Cells) (cluster #1 Of 3), Other | Other | 40 | 0.27 | Functional ≤ 10μM |
| Z81072-1-O | Jurkat (Acute Leukemic T-cells) (cluster #1 Of 10), Other | Other | 90 | 0.25 | Functional ≤ 10μM |
| Z81101-1-O | KBM-3 Cell Line (cluster #1 Of 1), Other | Other | 26 | 0.27 | Functional ≤ 10μM |
| Z81102-1-O | KBM-3/DOX Cell Line (cluster #1 Of 1), Other | Other | 490 | 0.23 | Functional ≤ 10μM |
| Z81115-2-O | KB (Squamous Cell Carcinoma) (cluster #2 Of 6), Other | Other | 600 | 0.22 | Functional ≤ 10μM |
| Z81115-2-O | KB (Squamous Cell Carcinoma) (cluster #2 Of 6), Other | Other | 7010 | 0.19 | Functional ≤ 10μM |
| Z81133-1-O | L1210 (1565) (cluster #1 Of 1), Other | Other | 315 | 0.23 | Functional ≤ 10μM |
| Z81134-1-O | L2987 (Lung Adenocarcinoma Cells) (cluster #1 Of 1), Other | Other | 300 | 0.23 | Functional ≤ 10μM |
| Z81160-1-O | Lewis Lung Carcinoma Cell Line (cluster #1 Of 1), Other | Other | 22 | 0.27 | Functional ≤ 10μM |
| Z81164-1-O | LL Cell Line (cluster #1 Of 2), Other | Other | 22 | 0.27 | Functional ≤ 10μM |
| Z81167-1-O | LLTC Cell Line (cluster #1 Of 1), Other | Other | 22 | 0.27 | Functional ≤ 10μM |
| Z81170-1-O | LNCaP (Prostate Carcinoma) (cluster #1 Of 5), Other | Other | 78 | 0.26 | Functional ≤ 10μM |
| Z81184-1-O | LOX IMVI (Melanoma Cells) (cluster #1 Of 5), Other | Other | 42 | 0.26 | Functional ≤ 10μM |
| Z81201-1-O | HOP-62 (Non-small Cell Lung Carcinoma Cells) (cluster #1 Of 3), Other | Other | 4 | 0.30 | Functional ≤ 10μM |
| Z81211-1-O | LXFL529 Cell Line (cluster #1 Of 1), Other | Other | 40 | 0.27 | Functional ≤ 10μM |
| Z81244-1-O | J774 (Macrophage Cells) (cluster #1 Of 1), Other | Other | 79 | 0.25 | Functional ≤ 10μM |
| Z81245-1-O | MDA-MB-435 (Breast Carcinoma Cells) (cluster #1 Of 6), Other | Other | 960 | 0.22 | Functional ≤ 10μM |
| Z81247-1-O | HeLa (Cervical Adenocarcinoma Cells) (cluster #1 Of 9), Other | Other | 710 | 0.22 | Functional ≤ 10μM |
| Z81247-1-O | HeLa (Cervical Adenocarcinoma Cells) (cluster #1 Of 9), Other | Other | 730 | 0.22 | Functional ≤ 10μM |
| Z81252-3-O | MDA-MB-231 (Breast Adenocarcinoma Cells) (cluster #3 Of 11), Other | Other | 70 | 0.26 | Functional ≤ 10μM |
| Z81252-3-O | MDA-MB-231 (Breast Adenocarcinoma Cells) (cluster #3 Of 11), Other | Other | 840 | 0.22 | Functional ≤ 10μM |
| Z81257-1-O | MEL-AC Cell Line (cluster #1 Of 1), Other | Other | 1200 | 0.21 | Functional ≤ 10μM |
| Z81261-1-O | UACC-375 (cluster #1 Of 1), Other | Other | 112 | 0.25 | Functional ≤ 10μM |
| Z81277-2-O | NCI-N417 (cluster #2 Of 2), Other | Other | 230 | 0.24 | Functional ≤ 10μM |
| Z81280-1-O | NCI-H226 (Non-small Cell Lung Carcinoma Cells) (cluster #1 Of 3), Other | Other | 8 | 0.29 | Functional ≤ 10μM |
| Z81284-1-O | NCI-H647 (cluster #1 Of 2), Other | Other | 1 | 0.32 | Functional ≤ 10μM |
| Z81331-1-O | SW-620 (Colon Adenocarcinoma Cells) (cluster #1 Of 6), Other | Other | 80 | 0.25 | Functional ≤ 10μM |
| Z81335-1-O | HCT-15 (Colon Adenocarcinoma Cells) (cluster #1 Of 5), Other | Other | 820 | 0.22 | Functional ≤ 10μM |
| Z81335-1-O | HCT-15 (Colon Adenocarcinoma Cells) (cluster #1 Of 5), Other | Other | 2320 | 0.20 | Functional ≤ 10μM |
| Z81341-1-O | Tumor Cell Lines (cluster #1 Of 1), Other | Other | 74 | 0.26 | Functional ≤ 10μM |
| Z100081-1-O | PBMC (Peripheral Blood Mononuclear Cells) (cluster #1 Of 2), Other | Other | 500 | 0.23 | ADME/T ≤ 10μM |
| Z80002-1-O | 1A9 (Ovarian Adenocarcinoma Cells) (cluster #1 Of 2), Other | Other | 100 | 0.25 | ADME/T ≤ 10μM |
| Z80005-1-O | 3T3 (Fibroblast Cells) (cluster #1 Of 2), Other | Other | 3700 | 0.19 | ADME/T ≤ 10μM |
| Z80035-1-O | B16 (Melanoma Cells) (cluster #1 Of 1), Other | Other | 100 | 0.25 | ADME/T ≤ 10μM |
| Z80054-1-O | Caco-2 (Colon Adenocarcinoma Cells) (cluster #1 Of 2), Other | Other | 600 | 0.22 | ADME/T ≤ 10μM |
| Z80064-1-O | CCRF-CEM (T-cell Leukemia) (cluster #1 Of 2), Other | Other | 60 | 0.26 | ADME/T ≤ 10μM |
| Z80166-1-O | HT-29 (Colon Adenocarcinoma Cells) (cluster #1 Of 2), Other | Other | 480 | 0.23 | ADME/T ≤ 10μM |
| Z80178-2-O | J774.A1 (Macrophage Cells) (cluster #2 Of 2), Other | Other | 20 | 0.28 | ADME/T ≤ 10μM |
| Z80186-1-O | K562 (Erythroleukemia Cells) (cluster #1 Of 3), Other | Other | 60 | 0.26 | ADME/T ≤ 10μM |
| Z80193-3-O | L1210 (Lymphocytic Leukemia Cells) (cluster #3 Of 4), Other | Other | 29 | 0.27 | ADME/T ≤ 10μM |
| Z80211-1-O | LoVo (Colon Adenocarcinoma Cells) (cluster #1 Of 1), Other | Other | 33 | 0.27 | ADME/T ≤ 10μM |
| Z80224-1-O | MCF7 (Breast Carcinoma Cells) (cluster #1 Of 2), Other | Other | 70 | 0.26 | ADME/T ≤ 10μM |
| Z80253-2-O | MEF (Embryonic Fibroblast Cells) (cluster #2 Of 2), Other | Other | 3400 | 0.20 | ADME/T ≤ 10μM |
| Z80291-1-O | MRC5 (Embryonic Lung Fibroblast Cells) (cluster #1 Of 3), Other | Other | 300 | 0.23 | ADME/T ≤ 10μM |
| Z80390-1-O | PC-3 (Prostate Carcinoma Cells) (cluster #1 Of 2), Other | Other | 2000 | 0.20 | ADME/T ≤ 10μM |
| Z80548-2-O | THP-1 (Acute Monocytic Leukemia Cells) (cluster #2 Of 4), Other | Other | 8 | 0.29 | ADME/T ≤ 10μM |
| Z80583-1-O | Vero (Kidney Cells) (cluster #1 Of 3), Other | Other | 7400 | 0.18 | ADME/T ≤ 10μM |
| Z80682-2-O | A549 (Lung Carcinoma Cells) (cluster #2 Of 3), Other | Other | 900 | 0.22 | ADME/T ≤ 10μM |
| Z80704-1-O | BJ (Foreskin Fibroblast Cells) (cluster #1 Of 2), Other | Other | 2700 | 0.20 | ADME/T ≤ 10μM |
| Z80936-4-O | HEK293 (Embryonic Kidney Fibroblasts) (cluster #4 Of 4), Other | Other | 64 | 0.26 | ADME/T ≤ 10μM |
| Z81020-1-O | HepG2 (Hepatoblastoma Cells) (cluster #1 Of 1), Other | Other | 420 | 0.23 | ADME/T ≤ 10μM |
| Z81024-1-O | NCI-H460 (Non-small Cell Lung Carcinoma) (cluster #1 Of 1), Other | Other | 10 | 0.29 | ADME/T ≤ 10μM |
| Z81034-2-O | A2780 (Ovarian Carcinoma Cells) (cluster #2 Of 2), Other | Other | 7 | 0.29 | ADME/T ≤ 10μM |
| Z81057-5-O | HUVEC (Umbilical Vein Endothelial Cells) (cluster #5 Of 5), Other | Other | 30 | 0.27 | ADME/T ≤ 10μM |
| Z81115-2-O | KB (Squamous Cell Carcinoma) (cluster #2 Of 3), Other | Other | 400 | 0.23 | ADME/T ≤ 10μM |
| Z81331-2-O | SW-620 (Colon Adenocarcinoma Cells) (cluster #2 Of 2), Other | Other | 178 | 0.24 | ADME/T ≤ 10μM |
| Q7ZJM1-1-V | Human Immunodeficiency Virus Type 1 Integrase (cluster #1 Of 6), Viral | Viruses | 900 | 0.22 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| TOP2A_HUMAN | P11388 | DNA Topoisomerase II Alpha, Human | 1000 | 0.22 | Binding ≤ 1μM |
| Q7ZJM1_9HIV1 | Q7ZJM1 | Human Immunodeficiency Virus Type 1 Integrase, 9hiv1 | 900 | 0.22 | Binding ≤ 1μM |
| AURKA_HUMAN | O14965 | Serine/threonine-protein Kinase Aurora-A, Human | 40 | 0.27 | Binding ≤ 1μM |
| TOP2A_HUMAN | P11388 | DNA Topoisomerase II Alpha, Human | 1000 | 0.22 | Binding ≤ 10μM |
| Z50643 | Z50643 | Hepatitis C Virus | 2600 | 0.20 | Binding ≤ 10μM |
| Q7ZJM1_9HIV1 | Q7ZJM1 | Human Immunodeficiency Virus Type 1 Integrase, 9hiv1 | 2400 | 0.20 | Binding ≤ 10μM |
| MMP2_HUMAN | P08253 | Matrix Metalloproteinase-2, Human | 1100 | 0.21 | Binding ≤ 10μM |
| AURKA_HUMAN | O14965 | Serine/threonine-protein Kinase Aurora-A, Human | 40 | 0.27 | Binding ≤ 10μM |
| Z103196 | Z103196 | 22RV1 | 1000 | 0.22 | Functional ≤ 10μM |
| Z80008 | Z80008 | 5637 (Epithelial Bladder Carcinoma Cells) | 20 | 0.28 | Functional ≤ 10μM |
| Z80640 | Z80640 | 786-0 (Renal Carcinoma Cells) | 3100 | 0.20 | Functional ≤ 10μM |
| Z80018 | Z80018 | A-375 (Malignant Melanoma Cells) | 70 | 0.26 | Functional ≤ 10μM |
| Z80852 | Z80852 | A-431 (Epidermoid Carcinoma Cells) | 50 | 0.26 | Functional ≤ 10μM |
| Z81034 | Z81034 | A2780 (Ovarian Carcinoma Cells) | 1.2 | 0.32 | Functional ≤ 10μM |
| Z80017 | Z80017 | A2780cisR (Cisplatin-resistant Ovarian Carcinoma Cells) | 17 | 0.28 | Functional ≤ 10μM |
| Z103203 | Z103203 | A375 | 10 | 0.29 | Functional ≤ 10μM |
| Z103205 | Z103205 | A431 | 190 | 0.24 | Functional ≤ 10μM |
| Z80021 | Z80021 | A498 (Renal Carcinoma Cells) | 35 | 0.27 | Functional ≤ 10μM |
| Z80682 | Z80682 | A549 (Lung Carcinoma Cells) | 10 | 0.29 | Functional ≤ 10μM |
| Z80661 | Z80661 | A704 (Renal Carcinoma Cells) | 2000 | 0.20 | Functional ≤ 10μM |
| Z80025 | Z80025 | ACHN (Renal Adenocarcinoma Cells) | 1 | 0.32 | Functional ≤ 10μM |
| Z80026 | Z80026 | AGS (Gastric Adenocarcinoma Cells) | 310 | 0.23 | Functional ≤ 10μM |
| Z80035 | Z80035 | B16 (Melanoma Cells) | 140 | 0.25 | Functional ≤ 10μM |
| Z80697 | Z80697 | Bel-7402 (Hepatoma Cells) | 1000 | 0.22 | Functional ≤ 10μM |
| Z80039 | Z80039 | BGC-823 (Stomach Adenocarcinoma Cells) | 1000 | 0.22 | Functional ≤ 10μM |
| Z80730 | Z80730 | C2D Cell Line | 46.5 | 0.26 | Functional ≤ 10μM |
| Z80731 | Z80731 | C2G Cell Line | 28.7 | 0.27 | Functional ≤ 10μM |
| Z80735 | Z80735 | C38 (Colon Carcinoma) | 10 | 0.29 | Functional ≤ 10μM |
| Z80052 | Z80052 | C8166 (Leukemic T-cells) | 20 | 0.28 | Functional ≤ 10μM |
| Z103219 | Z103219 | Ca9-22 | 1300 | 0.21 | Functional ≤ 10μM |
| Z80054 | Z80054 | Caco-2 (Colon Adenocarcinoma Cells) | 6700 | 0.19 | Functional ≤ 10μM |
| Z80064 | Z80064 | CCRF-CEM (T-cell Leukemia) | 100 | 0.25 | Functional ≤ 10μM |
| Z80068 | Z80068 | CCRF-SB (Lymphoblastic Leukemia Cells) | 10 | 0.29 | Functional ≤ 10μM |
| Z80874 | Z80874 | CEM (T-cell Leukemia) | 20 | 0.28 | Functional ≤ 10μM |
| Z80768 | Z80768 | CH1 (Ovarian Carcinoma Cells) | 450 | 0.23 | Functional ≤ 10μM |
| Z80088 | Z80088 | CHO (Ovarian Cells) | 60 | 0.26 | Functional ≤ 10μM |
| Z80092 | Z80092 | CHO-K1 (Ovarian Cells) | 1200 | 0.21 | Functional ≤ 10μM |
| Z80784 | Z80784 | Col2 (Colon Carcinoma Cells) | 520 | 0.23 | Functional ≤ 10μM |
| Z80105 | Z80105 | COR-L23 (Lung Carcinoma Cells) | 20.1 | 0.28 | Functional ≤ 10μM |
| Z80801 | Z80801 | CRL-7065 Cell Line | 500 | 0.23 | Functional ≤ 10μM |
| Z80114 | Z80114 | Daudi (Burkitts Lymphoma Cells) | 300 | 0.23 | Functional ≤ 10μM |
| TOP1_HUMAN | P11387 | DNA Topoisomerase I, Human | 9.6 | 0.29 | Functional ≤ 10μM |
| TOP1_MOUSE | Q04750 | DNA Topoisomerase I, Mouse | 15 | 0.28 | Functional ≤ 10μM |
| TOP2A_MOUSE | Q01320 | DNA Topoisomerase II Alpha, Mouse | 15 | 0.28 | Functional ≤ 10μM |
| TOP2A_HUMAN | P11388 | DNA Topoisomerase II Alpha, Human | 9.6 | 0.29 | Functional ≤ 10μM |
| TOP2B_MOUSE | Q64511 | DNA Topoisomerase II Beta, Mouse | 15 | 0.28 | Functional ≤ 10μM |
| TOP2B_HUMAN | Q02880 | DNA Topoisomerase II Beta, Human | 9.6 | 0.29 | Functional ≤ 10μM |
| Z80125 | Z80125 | DU-145 (Prostate Carcinoma) | 100 | 0.25 | Functional ≤ 10μM |
| Z80126 | Z80126 | DuPro | 1800 | 0.21 | Functional ≤ 10μM |
| Z80846 | Z80846 | F460pv8/eto Cell Line | 20 | 0.28 | Functional ≤ 10μM |
| Z80138 | Z80138 | G-361 (Melanoma Cells) | 90 | 0.25 | Functional ≤ 10μM |
| Z80887 | Z80887 | H2981 Cell Line | 500 | 0.23 | Functional ≤ 10μM |
| Z80145 | Z80145 | H69 | 137 | 0.25 | Functional ≤ 10μM |
| Z80928 | Z80928 | HCT-116 (Colon Carcinoma Cells) | 100 | 0.25 | Functional ≤ 10μM |
| Z81335 | Z81335 | HCT-15 (Colon Adenocarcinoma Cells) | 100 | 0.25 | Functional ≤ 10μM |
| Z80936 | Z80936 | HEK293 (Embryonic Kidney Fibroblasts) | 900 | 0.22 | Functional ≤ 10μM |
| Z80943 | Z80943 | HEL 299 | 1700 | 0.21 | Functional ≤ 10μM |
| Z81247 | Z81247 | HeLa (Cervical Adenocarcinoma Cells) | 1000 | 0.22 | Functional ≤ 10μM |
| Z80945 | Z80945 | HEp-2 (Laryngeal Carcinoma Cells) | 40 | 0.27 | Functional ≤ 10μM |
| Z50643 | Z50643 | Hepatitis C Virus | 300 | 0.23 | Functional ≤ 10μM |
| Z81020 | Z81020 | HepG2 (Hepatoblastoma Cells) | 100 | 0.25 | Functional ≤ 10μM |
| Z80156 | Z80156 | HL-60 (Promyeloblast Leukemia Cells) | 0.1 | 0.36 | Functional ≤ 10μM |
| Z50587 | Z50587 | Homo Sapiens | 100 | 0.25 | Functional ≤ 10μM |
| Z81201 | Z81201 | HOP-62 (Non-small Cell Lung Carcinoma Cells) | 4 | 0.30 | Functional ≤ 10μM |
| Z80164 | Z80164 | HT-1080 (Fibrosarcoma Cells) | 100 | 0.25 | Functional ≤ 10μM |
| Z80166 | Z80166 | HT-29 (Colon Adenocarcinoma Cells) | 0.1 | 0.36 | Functional ≤ 10μM |
| Z81005 | Z81005 | HTB-54 Cell Line | 1100 | 0.21 | Functional ≤ 10μM |
| Z81006 | Z81006 | Human Breast 401NL Tumor Cell Line | 10 | 0.29 | Functional ≤ 10μM |
| Z81025 | Z81025 | Human Lung LXF 529L Tumor Cell Line | 30 | 0.27 | Functional ≤ 10μM |
| Z81026 | Z81026 | Human Lung LXF 629L Tumor Cell Line | 70 | 0.26 | Functional ≤ 10μM |
| Z81028 | Z81028 | Human Melanoma Cell Line | 280 | 0.24 | Functional ≤ 10μM |
| Z80175 | Z80175 | IMR-32 (Neuroblastoma Cells) | 10 | 0.29 | Functional ≤ 10μM |
| Z81244 | Z81244 | J774 (Macrophage Cells) | 79.4 | 0.25 | Functional ≤ 10μM |
| Z80819 | Z80819 | J774.2 | 2752.5 | 0.20 | Functional ≤ 10μM |
| Z81072 | Z81072 | Jurkat (Acute Leukemic T-cells) | 1700 | 0.21 | Functional ≤ 10μM |
| Z80186 | Z80186 | K562 (Erythroleukemia Cells) | 10 | 0.29 | Functional ≤ 10μM |
| Z81115 | Z81115 | KB (Squamous Cell Carcinoma) | 0.23 | 0.35 | Functional ≤ 10μM |
| Z80188 | Z80188 | KB 3-1 (Cervical Epithelial Carcinoma Cells) | 21 | 0.28 | Functional ≤ 10μM |
| Z81101 | Z81101 | KBM-3 Cell Line | 26 | 0.27 | Functional ≤ 10μM |
| Z81102 | Z81102 | KBM-3/DOX Cell Line | 490 | 0.23 | Functional ≤ 10μM |
| Z81133 | Z81133 | L1210 (1565) | 22 | 0.27 | Functional ≤ 10μM |
| Z80193 | Z80193 | L1210 (Lymphocytic Leukemia Cells) | 0.1 | 0.36 | Functional ≤ 10μM |
| Z81134 | Z81134 | L2987 (Lung Adenocarcinoma Cells) | 300 | 0.23 | Functional ≤ 10μM |
| Z81160 | Z81160 | Lewis Lung Carcinoma Cell Line | 22 | 0.27 | Functional ≤ 10μM |
| Z81164 | Z81164 | LL Cell Line | 22 | 0.27 | Functional ≤ 10μM |
| Z81167 | Z81167 | LLTC Cell Line | 22 | 0.27 | Functional ≤ 10μM |
| Z81170 | Z81170 | LNCaP (Prostate Carcinoma) | 1660 | 0.21 | Functional ≤ 10μM |
| Z80211 | Z80211 | LoVo (Colon Adenocarcinoma Cells) | 1000 | 0.22 | Functional ≤ 10μM |
| Z81184 | Z81184 | LOX IMVI (Melanoma Cells) | 42 | 0.26 | Functional ≤ 10μM |
| Z81211 | Z81211 | LXFL529 Cell Line | 40 | 0.27 | Functional ≤ 10μM |
| Z80214 | Z80214 | M14 (Melanoma Cells) | 1000 | 0.22 | Functional ≤ 10μM |
| Z80224 | Z80224 | MCF7 (Breast Carcinoma Cells) | 0.7 | 0.33 | Functional ≤ 10μM |
| Z80227 | Z80227 | MCF7-ADR (Breast Carcinoma Cells) | 10000 | 0.18 | Functional ≤ 10μM |
| Z81252 | Z81252 | MDA-MB-231 (Breast Adenocarcinoma Cells) | 100 | 0.25 | Functional ≤ 10μM |
| Z80240 | Z80240 | MDA-MB-361 | 12 | 0.28 | Functional ≤ 10μM |
| Z81245 | Z81245 | MDA-MB-435 (Breast Carcinoma Cells) | 1300 | 0.21 | Functional ≤ 10μM |
| Z80243 | Z80243 | MDA-MB-453 (Breast Adenocarcinoma Cells) | 120 | 0.25 | Functional ≤ 10μM |
| Z80244 | Z80244 | MDA-MB-468 (Breast Adenocarcinoma) | 5 | 0.30 | Functional ≤ 10μM |
| Z81257 | Z81257 | MEL-AC Cell Line | 1200 | 0.21 | Functional ≤ 10μM |
| Z80254 | Z80254 | MES-SA (Uterine Sarcoma Cells) | 1560 | 0.21 | Functional ≤ 10μM |
| Z80255 | Z80255 | MES-SA/DxS (Uterine Sarcoma Cells) | 704 | 0.22 | Functional ≤ 10μM |
| Z80267 | Z80267 | MKN-1 | 640 | 0.22 | Functional ≤ 10μM |
| Z80269 | Z80269 | MKN-45 (Gastric Adenocarcinoma Cells) | 3130 | 0.20 | Functional ≤ 10μM |
| Z80285 | Z80285 | MOLT-4 (Acute T-lymphoblastic Leukemia Cells) | 0.1 | 0.36 | Functional ≤ 10μM |
| Z80291 | Z80291 | MRC5 (Embryonic Lung Fibroblast Cells) | 100 | 0.25 | Functional ≤ 10μM |
| Z80295 | Z80295 | MT4 (Lymphocytes) | 10 | 0.29 | Functional ≤ 10μM |
| Z81043 | Z81043 | N592 | 40 | 0.27 | Functional ≤ 10μM |
| Z81280 | Z81280 | NCI-H226 (Non-small Cell Lung Carcinoma Cells) | 8 | 0.29 | Functional ≤ 10μM |
| Z80889 | Z80889 | NCI-H322M (Non-small Cell Lung Carcinoma Cells) | 30 | 0.27 | Functional ≤ 10μM |
| Z80322 | Z80322 | NCI-H358 (Lung Carcinama Cells) | 130 | 0.25 | Functional ≤ 10μM |
| Z81024 | Z81024 | NCI-H460 (Non-small Cell Lung Carcinoma) | 10 | 0.29 | Functional ≤ 10μM |
| Z81284 | Z81284 | NCI-H647 | 1 | 0.32 | Functional ≤ 10μM |
| Z80896 | Z80896 | NCI-H69 (Small Cell Lung Carcinoma Cells) | 11.3 | 0.29 | Functional ≤ 10μM |
| Z81277 | Z81277 | NCI-N417 | 230 | 0.24 | Functional ≤ 10μM |
| Z80330 | Z80330 | NCI-N87 | 419.8 | 0.23 | Functional ≤ 10μM |
| Z80354 | Z80354 | OVCAR-3 (Ovarian Adenocarcinoma Cells) | 35 | 0.27 | Functional ≤ 10μM |
| Z80362 | Z80362 | P388 (Lymphoma Cells) | 1220 | 0.21 | Functional ≤ 10μM |
| Z80364 | Z80364 | P388/ADR (Lymphoma Cells) | 123 | 0.25 | Functional ≤ 10μM |
| Z80367 | Z80367 | P388/S | 19 | 0.28 | Functional ≤ 10μM |
| Z80389 | Z80389 | PC-14 | 1900 | 0.21 | Functional ≤ 10μM |
| Z80390 | Z80390 | PC-3 (Prostate Carcinoma Cells) | 102.8 | 0.25 | Functional ≤ 10μM |
| Z80414 | Z80414 | Raji (B-lymphoblastic Cells) | 100 | 0.25 | Functional ≤ 10μM |
| Z80433 | Z80433 | RPMI-8226 (Multiple Myeloma Cells) | 33 | 0.27 | Functional ≤ 10μM |
| Z80441 | Z80441 | RXF 944 | 60 | 0.26 | Functional ≤ 10μM |
| Z50347 | Z50347 | Saccharomyces Cerevisiae | 10000 | 0.18 | Functional ≤ 10μM |
| Z81054 | Z81054 | SF-268 (Glioblastoma Cells) | 1550 | 0.21 | Functional ≤ 10μM |
| Z80468 | Z80468 | SF-295 (Glioblastoma Cells) | 35 | 0.27 | Functional ≤ 10μM |
| Z80466 | Z80466 | SF268 | 220 | 0.24 | Functional ≤ 10μM |
| Z80472 | Z80472 | SiHa (Cervical Squamous Cell Carcinoma) | 1500 | 0.21 | Functional ≤ 10μM |
| Z80475 | Z80475 | SK-BR-3 (Breast Adenocarcinoma) | 20 | 0.28 | Functional ≤ 10μM |
| Z80479 | Z80479 | SK-MEL (Melanoma Cells) | 1200 | 0.21 | Functional ≤ 10μM |
| Z80481 | Z80481 | SK-MEL-1 (Metastatic Melanoma Cells) | 3092 | 0.20 | Functional ≤ 10μM |
| Z80482 | Z80482 | SK-MEL-2 (Melanoma Cells) | 117 | 0.25 | Functional ≤ 10μM |
| Z80485 | Z80485 | SK-MEL-28 (Melanoma Cells) | 20 | 0.28 | Functional ≤ 10μM |
| Z80490 | Z80490 | SK-MES-1 | 30 | 0.27 | Functional ≤ 10μM |
| Z80491 | Z80491 | SK-N-MC (Neuroepithelioma Cells) | 120 | 0.25 | Functional ≤ 10μM |
| Z80492 | Z80492 | SK-N-SH (Neuroblastoma Cells) | 1100 | 0.21 | Functional ≤ 10μM |
| Z80493 | Z80493 | SK-OV-3 (Ovarian Carcinoma Cells) | 1 | 0.32 | Functional ≤ 10μM |
| Z80495 | Z80495 | SK-VLB | 5600 | 0.19 | Functional ≤ 10μM |
| Z80477 | Z80477 | SK_HEP1 (Hepatoma Cells) | 100 | 0.25 | Functional ≤ 10μM |
| Z80509 | Z80509 | SNU-638 (Gastric Carcinoma Cells) | 690 | 0.22 | Functional ≤ 10μM |
| Z80503 | Z80503 | SNU1 | 4000 | 0.19 | Functional ≤ 10μM |
| Z81331 | Z81331 | SW-620 (Colon Adenocarcinoma Cells) | 120 | 0.25 | Functional ≤ 10μM |
| Z80526 | Z80526 | SW480 (Colon Adenocarcinoma Cells) | 60 | 0.26 | Functional ≤ 10μM |
| Z80532 | Z80532 | T-24 (Bladder Carcinoma Cells) | 20 | 0.28 | Functional ≤ 10μM |
| Z80712 | Z80712 | T47D (Breast Carcinoma Cells) | 100 | 0.25 | Functional ≤ 10μM |
| Z80726 | Z80726 | TRAMP-C1A (Prostate Carcinoma Cells) | 75.9 | 0.26 | Functional ≤ 10μM |
| Z80732 | Z80732 | TRAMP-C2H (Prostate Carcinoma Cells) | 30.3 | 0.27 | Functional ≤ 10μM |
| Z81341 | Z81341 | Tumor Cell Lines | 74 | 0.26 | Functional ≤ 10μM |
| Z80560 | Z80560 | U-251 (Glioma Cells) | 90 | 0.25 | Functional ≤ 10μM |
| Z80563 | Z80563 | U-373 MG ( Glioblastoma Cells) | 10 | 0.29 | Functional ≤ 10μM |
| Z80565 | Z80565 | U-87 MG (Glioblastoma Cells) | 140 | 0.25 | Functional ≤ 10μM |
| Z80559 | Z80559 | U251 | 320 | 0.23 | Functional ≤ 10μM |
| Z81261 | Z81261 | UACC-375 | 112 | 0.25 | Functional ≤ 10μM |
| Z80574 | Z80574 | UMUC3 | 9.2 | 0.29 | Functional ≤ 10μM |
| Z80581 | Z80581 | VA13 | 220 | 0.24 | Functional ≤ 10μM |
| Z80583 | Z80583 | Vero (Kidney Cells) | 5000 | 0.19 | Functional ≤ 10μM |
| Z81017 | Z81017 | WiDr (Colon Adenocarcinoma Cells) | 130 | 0.25 | Functional ≤ 10μM |
| Z80595 | Z80595 | WIL2-NS (Lymphoblastoid Cells) | 20 | 0.28 | Functional ≤ 10μM |
| Z80600 | Z80600 | XF498 (Glioma Cells) | 112 | 0.25 | Functional ≤ 10μM |
| Z80608 | Z80608 | ZR-75-1 (Breast Carcinoma Cells) | 9 | 0.29 | Functional ≤ 10μM |
| Z80002 | Z80002 | 1A9 (Ovarian Adenocarcinoma Cells) | 100 | 0.25 | ADME/T ≤ 10μM |
| Z80005 | Z80005 | 3T3 (Fibroblast Cells) | 3700 | 0.19 | ADME/T ≤ 10μM |
| Z81034 | Z81034 | A2780 (Ovarian Carcinoma Cells) | 290 | 0.23 | ADME/T ≤ 10μM |
| Z80682 | Z80682 | A549 (Lung Carcinoma Cells) | 900 | 0.22 | ADME/T ≤ 10μM |
| Z80035 | Z80035 | B16 (Melanoma Cells) | 100 | 0.25 | ADME/T ≤ 10μM |
| Z80704 | Z80704 | BJ (Foreskin Fibroblast Cells) | 2330 | 0.20 | ADME/T ≤ 10μM |
| Z80054 | Z80054 | Caco-2 (Colon Adenocarcinoma Cells) | 600 | 0.22 | ADME/T ≤ 10μM |
| Z80064 | Z80064 | CCRF-CEM (T-cell Leukemia) | 60 | 0.26 | ADME/T ≤ 10μM |
| Z80936 | Z80936 | HEK293 (Embryonic Kidney Fibroblasts) | 64 | 0.26 | ADME/T ≤ 10μM |
| Z81020 | Z81020 | HepG2 (Hepatoblastoma Cells) | 200 | 0.24 | ADME/T ≤ 10μM |
| Z80166 | Z80166 | HT-29 (Colon Adenocarcinoma Cells) | 480 | 0.23 | ADME/T ≤ 10μM |
| Z81057 | Z81057 | HUVEC (Umbilical Vein Endothelial Cells) | 30.3 | 0.27 | ADME/T ≤ 10μM |
| Z80178 | Z80178 | J774.A1 (Macrophage Cells) | 20 | 0.28 | ADME/T ≤ 10μM |
| Z80186 | Z80186 | K562 (Erythroleukemia Cells) | 60 | 0.26 | ADME/T ≤ 10μM |
| Z81115 | Z81115 | KB (Squamous Cell Carcinoma) | 300 | 0.23 | ADME/T ≤ 10μM |
| Z80193 | Z80193 | L1210 (Lymphocytic Leukemia Cells) | 29 | 0.27 | ADME/T ≤ 10μM |
| Z80211 | Z80211 | LoVo (Colon Adenocarcinoma Cells) | 33 | 0.27 | ADME/T ≤ 10μM |
| Z80224 | Z80224 | MCF7 (Breast Carcinoma Cells) | 200 | 0.24 | ADME/T ≤ 10μM |
| Z80253 | Z80253 | MEF (Embryonic Fibroblast Cells) | 3400 | 0.20 | ADME/T ≤ 10μM |
| Z80291 | Z80291 | MRC5 (Embryonic Lung Fibroblast Cells) | 100 | 0.25 | ADME/T ≤ 10μM |
| Z81024 | Z81024 | NCI-H460 (Non-small Cell Lung Carcinoma) | 10 | 0.29 | ADME/T ≤ 10μM |
| Z100081 | Z100081 | PBMC (Peripheral Blood Mononuclear Cells) | 1660 | 0.21 | ADME/T ≤ 10μM |
| Z80390 | Z80390 | PC-3 (Prostate Carcinoma Cells) | 2000 | 0.20 | ADME/T ≤ 10μM |
| Z81331 | Z81331 | SW-620 (Colon Adenocarcinoma Cells) | 178 | 0.24 | ADME/T ≤ 10μM |
| Z80548 | Z80548 | THP-1 (Acute Monocytic Leukemia Cells) | 50 | 0.26 | ADME/T ≤ 10μM |
| Z80583 | Z80583 | Vero (Kidney Cells) | 3600 | 0.20 | ADME/T ≤ 10μM |
| Description | Species |
|---|---|
| Activation of Matrix Metalloproteinases | |
| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins | |
| Collagen degradation | |
| Degradation of the extracellular matrix | |
| EPH-ephrin mediated repulsion of cells | |
| G0 and Early G1 | |
| Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l | |
| Regulation of PLK1 Activity at G2/M Transition |
