| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| November 9th, 2004 | 10 | Yes |
Popular Name: D-Glutamic acid D-Glutamic acid
Find On: PubMed — Wikipedia — Google
CAS Numbers: , 138-15-8 , 15767-75-6 , 19258-83-7 , 19285-83-7 , 24595-14-0 , 53931-70-7 , 5408-52-6 , 56-86-0 , 6106-04-3 , 617-65-2 , 6893-26-1 , [15767-75-6] , [19285-83-7] , [617-65-2] , [6893-26-1]
"DL-Glutamic acid monohydrate, 98%"
(R)-2-Aminoglutaric acid, (R)-2-Aminopentanedioic acid
(R)-2-aminopentanedioic acid; D-Glutaminsaeure; glutamic acid D-form
2,3,3,4,4-pentadeuterioglutamic acid; glutamic acid-d5
2-Aminoglutaric acid; 617-65-2; C00302; DL-Glutamate; DL-Glutaminic acid; Glutamate; Glutamic acid
2-Aminopentanedioic acid hydrate
2-Aminopentanedioic acid hydrochloride
617-65-2; D04341; DL-Glutamic acid; Glutamic acid (USAN)
6893-26-1; D-GLT; D-glutamate; D-glutamic acid
DL-2-Aminoglutaric acid monohydrate
Dl-glutamic acid hydrochloride
DL-Glutamic acid monohydrate, 98+%
DL-Glutamic acid monohydrate, 99%
gamma-poly(D-glutamic acid) macromolecule
gamma-poly(glutamic acid) macromolecule
Glutamic acid, zinc salt, DL-; LS-71896; Zinc DL-glutamate (1:1); Zinc, (DL-glutamato(2-)-N,O1)-
L-2-Aminoglutaric acid hydrochloride
L-Glutamic acid hydrochloride, 99%
MSG; sodium 2-ammoniopentanedioate; sodium glutamate
PDGA; gamma-poly(D-glutamic acid); poly(D-glutamicacid)
Potassium(S)-2-amino-4-carboxybutanoate
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | -3.25 | 1.72 | -74 | 3 | 5 | -1 | 108 | 146.122 | 4 | ↓ |
| Note Type | Comments | Provided By |
|---|---|---|
| Mp [°C] | 194 | Acros Organics |
| Melting_Point | 199? dec. | Alfa-Aesar |
| MP | 199° | Oakwood Chemical |
| Melting_Point | 199° dec. | Alfa-Aesar |
| MP | 199°(dec.) | Oakwood Chemical |
| Mp [°C] | 200 - 202 | Acros Organics |
| MP | 200-202 °C (subl.)(lit.) | Indofine |
| Melting_Point | 203? dec. | Alfa-Aesar |
| Melting_Point | 203° dec. | Alfa-Aesar |
| purity | 9.500000000000000e+001 | Enamine Building Blocks |
| BP | 94-97°/3mm | Oakwood Chemical |
| purity | 95 | Enamine Building Blocks |
| Purity | 95% | Fluorochem |
| Purity | 95+% | Matrix Scientific |
| Purity | 98% | Fluorochem |
| UniProt Database Links | AEPE_BPA18; AEPE_BPA50; COFF_METJA; DAAA_BACLI; DAAA_BACSU; DAAA_BACYM; DAAA_LISIN; DAAA_LISM4; DAAA_LISMF; DAAA_LISMO; DAAA_LYSSH; DAAA_STAAC; DAAA_STAAM; DAAA_STAAN; DAAA_STAAR; DAAA_STAAS; DAAA_STAAW; DAAA_STAEQ; DAAA_STAES; DAAA_STAHA; DAPDH_CORGL; DA | ChEBI |
| Melting_Point | ca 200? dec. | Alfa-Aesar |
| Melting_Point | ca 200° dec. | Alfa-Aesar |
| UniProt Database Links | CITE2_HUMAN; CITE2_MOUSE; GNAT3_BOVIN; GNAT3_HUMAN; GNAT3_MOUSE; GNAT3_RAT; MASZ_ECOLI; SER1_GALME; SER2_GALME; SERI1_BOMMO; SERO_GALME; TS1R1_HUMAN; TS1R1_MOUSE; TS1R1_RAT; TS1R3_CANFA; TS1R3_FELCA; TS1R3_GORGO; TS1R3_HUMAN; TS1R3_MOUSE; TS1R3_PANTR; TS1 | ChEBI |
| UniProt Database Links | CSPG4_HUMAN; CSPG4_MOUSE; CSPG4_RAT; ENOA_BOVIN; ENOA_HUMAN; ENOA_MACFA; ENOA_MESAU; ENOA_MOUSE; ENOA_PONAB; ENOA_RAT; ENOB_MOUSE; HRG_BOVIN; HRG_HUMAN; HRG_MOUSE; HRG_RABIT; HRG_RAT; PDGFC_HUMAN; PDGFC_MOUSE; PDGFC_RAT; PLMN_BOVIN; PLMN_CANFA; PLMN_CAPHI | ChEBI |
| PUBCHEM_PATENT_ID | EP0019081A1; US4352792 | IBM Patent Data |
| Patent Database Links | EP1422218; EP1541585; EP1550459; EP1586583; EP1683520; EP1745791; US2005085547; US2005130881; US2007191592; US2007197430; US2007213257; US7256172; WO2005021494; WO2005040338 | ChEBI |
| Warnings | IRRITANT | Matrix Scientific |
| Notes | Ph.Eur, Pyrogen free | Apollo Scientific Bioactives |
| S phrase | S24/25: Avoid contact with skin and eyes. | Acros Organics |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| MURI-2-B | Glutamate Racemase (cluster #2 Of 2), Bacterial | Bacteria | 5800 | 0.73 | Binding ≤ 10μM |
| GRIA1-3-E | Glutamate Receptor Ionotropic, AMPA 1 (cluster #3 Of 4), Eukaryotic | Eukaryotes | 1362 | 0.82 | Binding ≤ 10μM |
| GRIA2-3-E | Glutamate Receptor Ionotropic, AMPA 2 (cluster #3 Of 4), Eukaryotic | Eukaryotes | 940 | 0.84 | Binding ≤ 10μM |
| GRIA3-3-E | Glutamate Receptor Ionotropic, AMPA 3 (cluster #3 Of 4), Eukaryotic | Eukaryotes | 500 | 0.88 | Binding ≤ 10μM |
| GRIA4-3-E | Glutamate Receptor Ionotropic, AMPA 4 (cluster #3 Of 5), Eukaryotic | Eukaryotes | 868 | 0.85 | Binding ≤ 10μM |
| GRIK1-3-E | Glutamate Receptor Ionotropic Kainate 1 (cluster #3 Of 3), Eukaryotic | Eukaryotes | 701 | 0.86 | Binding ≤ 10μM |
| GRIK2-2-E | Glutamate Receptor Ionotropic Kainate 2 (cluster #2 Of 3), Eukaryotic | Eukaryotes | 1106 | 0.83 | Binding ≤ 10μM |
| GRIK3-2-E | Glutamate Receptor Ionotropic Kainate 3 (cluster #2 Of 3), Eukaryotic | Eukaryotes | 789 | 0.85 | Binding ≤ 10μM |
| GRIK4-2-E | Glutamate Receptor Ionotropic Kainate 4 (cluster #2 Of 2), Eukaryotic | Eukaryotes | 400 | 0.90 | Binding ≤ 10μM |
| GRIK5-2-E | Glutamate Receptor Ionotropic Kainate 5 (cluster #2 Of 2), Eukaryotic | Eukaryotes | 400 | 0.90 | Binding ≤ 10μM |
| GRM1-3-E | Metabotropic Glutamate Receptor 1 (cluster #3 Of 3), Eukaryotic | Eukaryotes | 4900 | 0.74 | Binding ≤ 10μM |
| GRM2-1-E | Metabotropic Glutamate Receptor 2 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 290 | 0.92 | Binding ≤ 10μM |
| GRM3-1-E | Metabotropic Glutamate Receptor 3 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 1900 | 0.80 | Binding ≤ 10μM |
| GRM4-3-E | Metabotropic Glutamate Receptor 4 (cluster #3 Of 3), Eukaryotic | Eukaryotes | 9800 | 0.70 | Binding ≤ 10μM |
| GRM5-4-E | Metabotropic Glutamate Receptor 5 (cluster #4 Of 5), Eukaryotic | Eukaryotes | 3100 | 0.77 | Binding ≤ 10μM |
| GRM6-1-E | Metabotropic Glutamate Receptor 6 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 4900 | 0.74 | Binding ≤ 10μM |
| NMDE1-4-E | Glutamate [NMDA] Receptor Subunit Epsilon 1 (cluster #4 Of 5), Eukaryotic | Eukaryotes | 200 | 0.94 | Binding ≤ 10μM |
| NMDE2-4-E | Glutamate [NMDA] Receptor Subunit Epsilon 2 (cluster #4 Of 5), Eukaryotic | Eukaryotes | 200 | 0.94 | Binding ≤ 10μM |
| NMDE3-3-E | Glutamate [NMDA] Receptor Subunit Epsilon 3 (cluster #3 Of 4), Eukaryotic | Eukaryotes | 200 | 0.94 | Binding ≤ 10μM |
| NMDE4-2-E | Glutamate [NMDA] Receptor Subunit Epsilon 4 (cluster #2 Of 6), Eukaryotic | Eukaryotes | 200 | 0.94 | Binding ≤ 10μM |
| GRIA1-3-E | Glutamate Receptor Ionotropic, AMPA 1 (cluster #3 Of 3), Eukaryotic | Eukaryotes | 214 | 0.93 | Functional ≤ 10μM |
| GRIA2-3-E | Glutamate Receptor Ionotropic, AMPA 2 (cluster #3 Of 4), Eukaryotic | Eukaryotes | 214 | 0.93 | Functional ≤ 10μM |
| GRIA3-2-E | Glutamate Receptor Ionotropic, AMPA 3 (cluster #2 Of 2), Eukaryotic | Eukaryotes | 214 | 0.93 | Functional ≤ 10μM |
| GRIA4-2-E | Glutamate Receptor Ionotropic, AMPA 4 (cluster #2 Of 3), Eukaryotic | Eukaryotes | 214 | 0.93 | Functional ≤ 10μM |
| GRM1-4-E | Metabotropic Glutamate Receptor 1 (cluster #4 Of 5), Eukaryotic | Eukaryotes | 1050 | 0.84 | Functional ≤ 10μM |
| GRM8-1-E | Metabotropic Glutamate Receptor 8 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 8000 | 0.71 | Functional ≤ 10μM |
| Z104302-3-O | Glutamate NMDA Receptor (cluster #3 Of 7), Other | Other | 80 | 0.99 | Binding ≤ 10μM |
| Z50597-7-O | Rattus Norvegicus (cluster #7 Of 12), Other | Other | 2500 | 0.78 | Functional ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| Z104302 | Z104302 | Glutamate NMDA Receptor | 70 | 1.00 | Binding ≤ 1μM |
| GRIK1_HUMAN | P39086 | Glutamate Receptor Ionotropic Kainate 1, Human | 701 | 0.86 | Binding ≤ 1μM |
| GRIK1_RAT | P22756 | Glutamate Receptor Ionotropic Kainate 1, Rat | 120 | 0.97 | Binding ≤ 1μM |
| GRIK2_RAT | P42260 | Glutamate Receptor Ionotropic Kainate 2, Rat | 120 | 0.97 | Binding ≤ 1μM |
| GRIK3_RAT | P42264 | Glutamate Receptor Ionotropic Kainate 3, Rat | 120 | 0.97 | Binding ≤ 1μM |
| GRIK3_HUMAN | Q13003 | Glutamate Receptor Ionotropic Kainate 3, Human | 789 | 0.85 | Binding ≤ 1μM |
| GRIK4_RAT | Q01812 | Glutamate Receptor Ionotropic Kainate 4, Rat | 120 | 0.97 | Binding ≤ 1μM |
| GRIK5_RAT | Q63273 | Glutamate Receptor Ionotropic Kainate 5, Rat | 120 | 0.97 | Binding ≤ 1μM |
| GRIK5_HUMAN | Q16478 | Glutamate Receptor Ionotropic Kainate 5, Human | 750 | 0.86 | Binding ≤ 1μM |
| GRIA1_MOUSE | P23818 | Glutamate Receptor Ionotropic, AMPA 1, Mouse | 150 | 0.96 | Binding ≤ 1μM |
| GRIA2_RAT | P19491 | Glutamate Receptor Ionotropic, AMPA 2, Rat | 150 | 0.96 | Binding ≤ 1μM |
| GRIA2_HUMAN | P42262 | Glutamate Receptor Ionotropic, AMPA 2, Human | 940 | 0.84 | Binding ≤ 1μM |
| GRIA3_RAT | P19492 | Glutamate Receptor Ionotropic, AMPA 3, Rat | 150 | 0.96 | Binding ≤ 1μM |
| GRIA4_HUMAN | P48058 | Glutamate Receptor Ionotropic, AMPA 4, Human | 868 | 0.85 | Binding ≤ 1μM |
| GRIA4_RAT | P19493 | Glutamate Receptor Ionotropic, AMPA 4, Rat | 150 | 0.96 | Binding ≤ 1μM |
| NMDE1_RAT | Q00959 | Glutamate [NMDA] Receptor Subunit Epsilon 1, Rat | 200 | 0.94 | Binding ≤ 1μM |
| NMDE2_RAT | Q00960 | Glutamate [NMDA] Receptor Subunit Epsilon 2, Rat | 200 | 0.94 | Binding ≤ 1μM |
| NMDE3_RAT | Q00961 | Glutamate [NMDA] Receptor Subunit Epsilon 3, Rat | 200 | 0.94 | Binding ≤ 1μM |
| NMDE4_RAT | Q62645 | Glutamate [NMDA] Receptor Subunit Epsilon 4, Rat | 200 | 0.94 | Binding ≤ 1μM |
| GRM1_HUMAN | Q13255 | Metabotropic Glutamate Receptor 1, Human | 340 | 0.91 | Binding ≤ 1μM |
| GRM2_HUMAN | Q14416 | Metabotropic Glutamate Receptor 2, Human | 290 | 0.92 | Binding ≤ 1μM |
| Z104302 | Z104302 | Glutamate NMDA Receptor | 70 | 1.00 | Binding ≤ 10μM |
| MURI_HELPY | P56068 | Glutamate Racemase, Helpy | 5800 | 0.73 | Binding ≤ 10μM |
| GRIK1_HUMAN | P39086 | Glutamate Receptor Ionotropic Kainate 1, Human | 701 | 0.86 | Binding ≤ 10μM |
| GRIK1_RAT | P22756 | Glutamate Receptor Ionotropic Kainate 1, Rat | 120 | 0.97 | Binding ≤ 10μM |
| GRIK2_HUMAN | Q13002 | Glutamate Receptor Ionotropic Kainate 2, Human | 1106 | 0.83 | Binding ≤ 10μM |
| GRIK2_RAT | P42260 | Glutamate Receptor Ionotropic Kainate 2, Rat | 120 | 0.97 | Binding ≤ 10μM |
| GRIK3_RAT | P42264 | Glutamate Receptor Ionotropic Kainate 3, Rat | 120 | 0.97 | Binding ≤ 10μM |
| GRIK3_HUMAN | Q13003 | Glutamate Receptor Ionotropic Kainate 3, Human | 789 | 0.85 | Binding ≤ 10μM |
| GRIK4_RAT | Q01812 | Glutamate Receptor Ionotropic Kainate 4, Rat | 120 | 0.97 | Binding ≤ 10μM |
| GRIK5_RAT | Q63273 | Glutamate Receptor Ionotropic Kainate 5, Rat | 120 | 0.97 | Binding ≤ 10μM |
| GRIK5_HUMAN | Q16478 | Glutamate Receptor Ionotropic Kainate 5, Human | 750 | 0.86 | Binding ≤ 10μM |
| GRIA1_MOUSE | P23818 | Glutamate Receptor Ionotropic, AMPA 1, Mouse | 150 | 0.96 | Binding ≤ 10μM |
| GRIA1_HUMAN | P42261 | Glutamate Receptor Ionotropic, AMPA 1, Human | 1362 | 0.82 | Binding ≤ 10μM |
| GRIA2_HUMAN | P42262 | Glutamate Receptor Ionotropic, AMPA 2, Human | 940 | 0.84 | Binding ≤ 10μM |
| GRIA2_RAT | P19491 | Glutamate Receptor Ionotropic, AMPA 2, Rat | 150 | 0.96 | Binding ≤ 10μM |
| GRIA3_RAT | P19492 | Glutamate Receptor Ionotropic, AMPA 3, Rat | 150 | 0.96 | Binding ≤ 10μM |
| GRIA4_HUMAN | P48058 | Glutamate Receptor Ionotropic, AMPA 4, Human | 868 | 0.85 | Binding ≤ 10μM |
| GRIA4_RAT | P19493 | Glutamate Receptor Ionotropic, AMPA 4, Rat | 150 | 0.96 | Binding ≤ 10μM |
| NMDE1_RAT | Q00959 | Glutamate [NMDA] Receptor Subunit Epsilon 1, Rat | 200 | 0.94 | Binding ≤ 10μM |
| NMDE2_RAT | Q00960 | Glutamate [NMDA] Receptor Subunit Epsilon 2, Rat | 200 | 0.94 | Binding ≤ 10μM |
| NMDE3_RAT | Q00961 | Glutamate [NMDA] Receptor Subunit Epsilon 3, Rat | 200 | 0.94 | Binding ≤ 10μM |
| NMDE4_RAT | Q62645 | Glutamate [NMDA] Receptor Subunit Epsilon 4, Rat | 200 | 0.94 | Binding ≤ 10μM |
| GRM1_RAT | P23385 | Metabotropic Glutamate Receptor 1, Rat | 10000 | 0.70 | Binding ≤ 10μM |
| GRM1_HUMAN | Q13255 | Metabotropic Glutamate Receptor 1, Human | 340 | 0.91 | Binding ≤ 10μM |
| GRM2_RAT | P31421 | Metabotropic Glutamate Receptor 2, Rat | 4000 | 0.76 | Binding ≤ 10μM |
| GRM2_HUMAN | Q14416 | Metabotropic Glutamate Receptor 2, Human | 1200 | 0.83 | Binding ≤ 10μM |
| GRM3_RAT | P31422 | Metabotropic Glutamate Receptor 3, Rat | 9000 | 0.71 | Binding ≤ 10μM |
| GRM3_HUMAN | Q14832 | Metabotropic Glutamate Receptor 3, Human | 1900 | 0.80 | Binding ≤ 10μM |
| GRM4_HUMAN | Q14833 | Metabotropic Glutamate Receptor 4, Human | 1600 | 0.81 | Binding ≤ 10μM |
| GRM5_HUMAN | P41594 | Metabotropic Glutamate Receptor 5, Human | 3100 | 0.77 | Binding ≤ 10μM |
| GRM5_RAT | P31424 | Metabotropic Glutamate Receptor 5, Rat | 4400 | 0.75 | Binding ≤ 10μM |
| GRM6_HUMAN | O15303 | Metabotropic Glutamate Receptor 6, Human | 4900 | 0.74 | Binding ≤ 10μM |
| GRIA1_RAT | P19490 | Glutamate Receptor Ionotropic, AMPA 1, Rat | 214 | 0.93 | Functional ≤ 10μM |
| GRIA2_RAT | P19491 | Glutamate Receptor Ionotropic, AMPA 2, Rat | 214 | 0.93 | Functional ≤ 10μM |
| GRIA3_RAT | P19492 | Glutamate Receptor Ionotropic, AMPA 3, Rat | 214 | 0.93 | Functional ≤ 10μM |
| GRIA4_RAT | P19493 | Glutamate Receptor Ionotropic, AMPA 4, Rat | 214 | 0.93 | Functional ≤ 10μM |
| GRM1_HUMAN | Q13255 | Metabotropic Glutamate Receptor 1, Human | 1050 | 0.84 | Functional ≤ 10μM |
| GRM1_RAT | P23385 | Metabotropic Glutamate Receptor 1, Rat | 3000 | 0.77 | Functional ≤ 10μM |
| GRM8_RAT | P70579 | Metabotropic Glutamate Receptor 8, Rat | 8000 | 0.71 | Functional ≤ 10μM |
| Z50597 | Z50597 | Rattus Norvegicus | 2500 | 0.78 | Functional ≤ 10μM |
| Description | Species |
|---|---|
| Activation of AMPA receptors | |
| Activation of Ca-permeable Kainate Receptor | |
| Activation of Na-permeable Kainate Receptors | |
| Class C/3 (Metabotropic glutamate/pheromone receptors) | |
| CREB phosphorylation through the activation of CaMKII | |
| G alpha (i) signalling events | |
| G alpha (q) signalling events | |
| Presynaptic function of Kainate receptors | |
| Ras activation uopn Ca2+ infux through NMDA receptor | |
| Trafficking of AMPA receptors | |
| Trafficking of GluR2-containing AMPA receptors | |
| Unblocking of NMDA receptor, glutamate binding and activation |
