| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| September 27th, 2005 | 21 | Yes |
Popular Name: Imipramine hydrochloride Imipramine hydrochloride
Find On: PubMed — Wikipedia — Google
CAS Numbers: 113-52-0 , 113-52-0, 50-49-7 , 113-52-0, 50-49-7 [imipramine] , 17321-77-6 , 50-49-7 , [113-52-0] , [17321-77-6] , [50-49-7]
1-(3-Dimethylaminopropyl)-4,5-dihydro-2,3,6,7-dibenzazepine
10,11-Dihydro-5-(3-(dimethylamino)propyl)-5H-dibenz[b,f]azepine
10,11-Dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-propanamine
113-52-0; C07982; Imipramine hydrochloride
113-52-0; CPD000058388; SAM002564216; Tofranil
113-52-0; D00815; Imipramine hydrochloride (JP16/USP); Tofranil (TN)
113-52-0; Imipramine hydrochloride; Prestwick_277
2,2'-(3-Dimethylaminopropylimino)bibenzyl
2,2'-(3-Dimethylaminopropylimino)dibenzyl
3-(10,11-Dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethyl-1-propanamine
3-(10,11-Dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethylpropan-1-amine
3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethylpropan-1-amine
3-Chloro-10,11-dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-propanamine hydrochloride
5,6-Dihydro-N-(3-(dimethylamino)propyl)-11H-dibenz(b,e)azepine
5,6-Dihydro-N-[3-(dimethylamino)propyl]-11H-dibenz[b,e]azepine
5-(3-(Dimethylamino)propyl)-10,11-dihydro-5H-dibenz(b,f)azepine
5-(3-Dimethylaminopropyl)-10,11-dihydro-5H-dibenzo(b,f)azepine
50-49-7; D08070; Imipramine (INN); Tofranil (TN)
5H-Dibenz(b,f)azepine, 10,11-dihydro-5-(3-(dimethylamino)propyl)-
5H-Dibenz(b,f)azepine, 5-(3-(dimethylamino)propyl)-10,11-dihydro-
5H-Dibenz(b,f)azepine,5-[3-(dimethylamino)propyl]-10,11-dihydro-mixed with ethyl alcohol
5H-Dibenz(b,f)azepine-5-propanamine, 10,11-dihydro-N,N-dimethyl-
5H-Dibenz(b,f)azepine-5-propanamine, 10,11-dihydro-N,N-dimethyl- (9CI)
5H-Dibenz[b,f]azepine, 5-[3-(dimethylamino)propyl]-10,11-dihydro-
5H-Dibenz[b,f]azepine-5-propanamine, 10,11-dihydro-N,N-dimethyl-
Antideprin hydrochloride; Imipramine hydrochloride
CPD000058388; Imipramine hydrochloride; SAM002564216
imipraminehydrochloride,berkomine,deprinol,dyna-zina,imiprin,iramil
INN); Imipramine Hydrochloride (FDA
INN); Imipramine Pamoate (FDA); Imipramine HCl (FDA
INN); Imipramine Pamoate (FDA); Imipramine HCl (JAN
N-(.gamma.-Dimethylaminopropyl)iminodibenzyl
N-(3-Dimethylaminopropyl)-o-iminodibenzyl
N-(gamma-Dimethylaminopropyl)iminodibenzyl
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 4.16 | 12.58 | -35.72 | 1 | 2 | 1 | 8 | 281.423 | 4 | ↓ |
| Note Type | Comments | Provided By |
|---|---|---|
| ALOGPS_SOLUBILITY | 6.64e-02 g/l | DrugBank-approved |
| Indications | antidepressant | KeyOrganics Bioactives |
| UniProt Database Links | AP2A_RAT; CP2CJ_HUMAN; CP2DF_CANFA; FMO2_HUMAN; LPLT1_CAEEL | ChEBI |
| Patent Database Links | EP0908186; EP1078637; EP1438962; EP1627639; EP1671628; EP1731142; EP1754712; EP1782813; EP1815846; EP1829527; EP1829528; EP1829534; EP1829539; EP1844769; EP1867641; EP1967202; EP1990639; US2004142904; US2004171682; US2005069596; US2005070552; US2005281845 | ChEBI |
| Patent Database Links | EP1655029; EP1915992; EP1987844; US2007185018; US2007196504 | ChEBI |
| PUBCHEM_SUBSTANCE_COMMENT | NCC_SAMPLE_SUPPLIER : LightBiologicals; NCC_SUPPLIER_STRUCTURE_ID : I-2060; NCC_SUPPLIER_SAMPLE_COMMENTS : OFF-WHITE POWDER; 1 hydrogen chloride | NIH Clinical Collection via PubChem |
| Target | Others | Selleck Chemicals |
| Reactome Database Links | REACT_22167; REACT_22373 | ChEBI |
| PUBCHEM_SUBSTANCE_COMMENT | SAMPLE_SUPPLIER: LightBiologicals; SUPPLIER_STRUCTURE_ID: I-2060; SALT: 1 hydrogen chloride; SUPPLIER_COMMENTS: OFF-WHITE POWDER | NIH Clinical Collection via PubChem |
| Therapy | Tricyclic antidepressant; blocks reuptake of serotonin and norepinephrine | SMDC Iconix |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| 5HT1A-1-E | Serotonin 1a (5-HT1a) Receptor (cluster #1 Of 4), Eukaryotic | Eukaryotes | 44 | 0.49 | Binding ≤ 10μM |
| 5HT1B-1-E | Serotonin 1b (5-HT1b) Receptor (cluster #1 Of 2), Eukaryotic | Eukaryotes | 44 | 0.49 | Binding ≤ 10μM |
| 5HT1D-1-E | Serotonin 1d (5-HT1d) Receptor (cluster #1 Of 2), Eukaryotic | Eukaryotes | 44 | 0.49 | Binding ≤ 10μM |
| 5HT1F-1-E | Serotonin 1f (5-HT1f) Receptor (cluster #1 Of 2), Eukaryotic | Eukaryotes | 44 | 0.49 | Binding ≤ 10μM |
| 5HT2A-1-E | Serotonin 2a (5-HT2a) Receptor (cluster #1 Of 3), Eukaryotic | Eukaryotes | 94 | 0.47 | Binding ≤ 10μM |
| 5HT2B-1-E | Serotonin 2b (5-HT2b) Receptor (cluster #1 Of 4), Eukaryotic | Eukaryotes | 44 | 0.49 | Binding ≤ 10μM |
| 5HT2C-1-E | Serotonin 2c (5-HT2c) Receptor (cluster #1 Of 3), Eukaryotic | Eukaryotes | 160 | 0.45 | Binding ≤ 10μM |
| 5HT4R-1-E | Serotonin 4 (5-HT4) Receptor (cluster #1 Of 1), Eukaryotic | Eukaryotes | 44 | 0.49 | Binding ≤ 10μM |
| 5HT5A-1-E | Serotonin 5a (5-HT5a) Receptor (cluster #1 Of 1), Eukaryotic | Eukaryotes | 44 | 0.49 | Binding ≤ 10μM |
| 5HT5B-1-E | Serotonin 5b (5-HT5b) Receptor (cluster #1 Of 1), Eukaryotic | Eukaryotes | 44 | 0.49 | Binding ≤ 10μM |
| 5HT6R-1-E | Serotonin 6 (5-HT6) Receptor (cluster #1 Of 2), Eukaryotic | Eukaryotes | 44 | 0.49 | Binding ≤ 10μM |
| 5HT7R-1-E | Serotonin 7 (5-HT7) Receptor (cluster #1 Of 3), Eukaryotic | Eukaryotes | 44 | 0.49 | Binding ≤ 10μM |
| AA3R-3-E | Adenosine Receptor A3 (cluster #3 Of 6), Eukaryotic | Eukaryotes | 4 | 0.56 | Binding ≤ 10μM |
| ACM5-2-E | Muscarinic Acetylcholine Receptor M5 (cluster #2 Of 4), Eukaryotic | Eukaryotes | 300 | 0.43 | Binding ≤ 10μM |
| ADA1A-2-E | Alpha-1a Adrenergic Receptor (cluster #2 Of 3), Eukaryotic | Eukaryotes | 46 | 0.49 | Binding ≤ 10μM |
| ADA1B-1-E | Alpha-1b Adrenergic Receptor (cluster #1 Of 4), Eukaryotic | Eukaryotes | 46 | 0.49 | Binding ≤ 10μM |
| ADA1D-1-E | Alpha-1d Adrenergic Receptor (cluster #1 Of 3), Eukaryotic | Eukaryotes | 46 | 0.49 | Binding ≤ 10μM |
| ADA2A-3-E | Alpha-2a Adrenergic Receptor (cluster #3 Of 4), Eukaryotic | Eukaryotes | 4900 | 0.35 | Binding ≤ 10μM |
| ADA2B-1-E | Alpha-2b Adrenergic Receptor (cluster #1 Of 4), Eukaryotic | Eukaryotes | 4900 | 0.35 | Binding ≤ 10μM |
| ADA2C-3-E | Alpha-2c Adrenergic Receptor (cluster #3 Of 4), Eukaryotic | Eukaryotes | 4900 | 0.35 | Binding ≤ 10μM |
| ADCY1-1-E | Brain Adenylate Cyclase 1 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 160 | 0.45 | Binding ≤ 10μM |
| ADCY2-2-E | Adenylate Cyclase Type II (cluster #2 Of 2), Eukaryotic | Eukaryotes | 160 | 0.45 | Binding ≤ 10μM |
| ADCY8-1-E | Adenylate Cyclase Type VIII (cluster #1 Of 2), Eukaryotic | Eukaryotes | 160 | 0.45 | Binding ≤ 10μM |
| ADRB1-1-E | Beta-1 Adrenergic Receptor (cluster #1 Of 2), Eukaryotic | Eukaryotes | 46 | 0.49 | Binding ≤ 10μM |
| ADRB2-1-E | Beta-2 Adrenergic Receptor (cluster #1 Of 2), Eukaryotic | Eukaryotes | 46 | 0.49 | Binding ≤ 10μM |
| ADRB3-1-E | Beta-3 Adrenergic Receptor (cluster #1 Of 2), Eukaryotic | Eukaryotes | 46 | 0.49 | Binding ≤ 10μM |
| DRD1-1-E | Dopamine D1 Receptor (cluster #1 Of 4), Eukaryotic | Eukaryotes | 645 | 0.41 | Binding ≤ 10μM |
| DRD3-1-E | Dopamine D3 Receptor (cluster #1 Of 2), Eukaryotic | Eukaryotes | 645 | 0.41 | Binding ≤ 10μM |
| DRD4-3-E | Dopamine D4 Receptor (cluster #3 Of 4), Eukaryotic | Eukaryotes | 645 | 0.41 | Binding ≤ 10μM |
| DRD5-1-E | Dopamine D5 Receptor (cluster #1 Of 1), Eukaryotic | Eukaryotes | 645 | 0.41 | Binding ≤ 10μM |
| HRH1-2-E | Histamine H1 Receptor (cluster #2 Of 2), Eukaryotic | Eukaryotes | 30 | 0.50 | Binding ≤ 10μM |
| HRH2-2-E | Histamine H2 Receptor (cluster #2 Of 3), Eukaryotic | Eukaryotes | 30 | 0.50 | Binding ≤ 10μM |
| HRH3-1-E | Histamine H3 Receptor (cluster #1 Of 3), Eukaryotic | Eukaryotes | 30 | 0.50 | Binding ≤ 10μM |
| HRH4-1-E | Histamine H4 Receptor (cluster #1 Of 4), Eukaryotic | Eukaryotes | 30 | 0.50 | Binding ≤ 10μM |
| KCNH2-5-E | HERG (cluster #5 Of 5), Eukaryotic | Eukaryotes | 5470 | 0.35 | Binding ≤ 10μM |
| PRIO-1-E | Prion Protein (cluster #1 Of 1), Eukaryotic | Eukaryotes | 10000 | 0.33 | Binding ≤ 10μM |
| Q9WTR4-1-E | Norepinephrine Transporter (cluster #1 Of 2), Eukaryotic | Eukaryotes | 3 | 0.57 | Binding ≤ 10μM |
| SC6A2-1-E | Norepinephrine Transporter (cluster #1 Of 2), Eukaryotic | Eukaryotes | 74 | 0.48 | Binding ≤ 10μM |
| SC6A3-1-E | Dopamine Transporter (cluster #1 Of 3), Eukaryotic | Eukaryotes | 42 | 0.49 | Binding ≤ 10μM |
| SC6A4-3-E | Serotonin Transporter (cluster #3 Of 4), Eukaryotic | Eukaryotes | 5 | 0.55 | Binding ≤ 10μM |
| SCN1A-1-E | Sodium Channel Protein Type I Alpha Subunit (cluster #1 Of 2), Eukaryotic | Eukaryotes | 3600 | 0.36 | Binding ≤ 10μM |
| SCN2A-1-E | Sodium Channel Protein Type II Alpha Subunit (cluster #1 Of 2), Eukaryotic | Eukaryotes | 3600 | 0.36 | Binding ≤ 10μM |
| SCN3A-1-E | Sodium Channel Protein Type III Alpha Subunit (cluster #1 Of 2), Eukaryotic | Eukaryotes | 3600 | 0.36 | Binding ≤ 10μM |
| SCN8A-1-E | Sodium Channel Protein Type VIII Alpha Subunit (cluster #1 Of 2), Eukaryotic | Eukaryotes | 3600 | 0.36 | Binding ≤ 10μM |
| HRH2-1-E | Histamine H2 Receptor (cluster #1 Of 2), Eukaryotic | Eukaryotes | 1900 | 0.38 | Functional ≤ 10μM |
| KCNH2-1-E | HERG (cluster #1 Of 2), Eukaryotic | Eukaryotes | 3400 | 0.36 | Functional ≤ 10μM |
| Q9WTR4-1-E | Norepinephrine Transporter (cluster #1 Of 2), Eukaryotic | Eukaryotes | 60 | 0.48 | Functional ≤ 10μM |
| SC6A4-1-E | Serotonin Transporter (cluster #1 Of 1), Eukaryotic | Eukaryotes | 810 | 0.41 | Functional ≤ 10μM |
| DRD2-14-E | Dopamine D2 Receptor (cluster #14 Of 24), Eukaryotic | Eukaryotes | 645 | 0.41 | Binding ≤ 10μM |
| Z104303-1-O | Muscarinic Acetylcholine Receptor (cluster #1 Of 7), Other | Other | 65 | 0.48 | Binding ≤ 10μM |
| Z104304-1-O | Adrenergic Receptor Alpha-1 (cluster #1 Of 3), Other | Other | 46 | 0.49 | Binding ≤ 10μM |
| Z50597-1-O | Rattus Norvegicus (cluster #1 Of 5), Other | Other | 12 | 0.53 | Binding ≤ 10μM |
| Z50425-3-O | Plasmodium Falciparum (cluster #3 Of 22), Other | Other | 1259 | 0.39 | Functional ≤ 10μM |
| Z50594-6-O | Mus Musculus (cluster #6 Of 9), Other | Other | 300 | 0.43 | Functional ≤ 10μM |
| Z50597-12-O | Rattus Norvegicus (cluster #12 Of 12), Other | Other | 85 | 0.47 | Functional ≤ 10μM |
| Z81138-1-O | ScN2a (Scrapie-infected Neuroblastoma Cells) (cluster #1 Of 3), Other | Other | 5000 | 0.35 | Functional ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| AA3R_HUMAN | P33765 | Adenosine A3 Receptor, Human | 4.4 | 0.56 | Binding ≤ 1μM |
| ADCY2_HUMAN | Q08462 | Adenylate Cyclase Type II, Human | 160 | 0.45 | Binding ≤ 1μM |
| ADCY8_HUMAN | P40145 | Adenylate Cyclase Type VIII, Human | 160 | 0.45 | Binding ≤ 1μM |
| Z104304 | Z104304 | Adrenergic Receptor Alpha-1 | 160 | 0.45 | Binding ≤ 1μM |
| ADA1A_RAT | P43140 | Alpha-1a Adrenergic Receptor, Rat | 1.7 | 0.58 | Binding ≤ 1μM |
| ADA1B_RAT | P15823 | Alpha-1b Adrenergic Receptor, Rat | 46 | 0.49 | Binding ≤ 1μM |
| ADA1D_RAT | P23944 | Alpha-1d Adrenergic Receptor, Rat | 46 | 0.49 | Binding ≤ 1μM |
| ADA2A_RAT | P22909 | Alpha-2a Adrenergic Receptor, Rat | 255 | 0.44 | Binding ≤ 1μM |
| ADA2B_RAT | P19328 | Alpha-2b Adrenergic Receptor, Rat | 255 | 0.44 | Binding ≤ 1μM |
| ADA2C_RAT | P22086 | Alpha-2c Adrenergic Receptor, Rat | 255 | 0.44 | Binding ≤ 1μM |
| ADRB1_RAT | P18090 | Beta-1 Adrenergic Receptor, Rat | 46 | 0.49 | Binding ≤ 1μM |
| ADRB2_RAT | P10608 | Beta-2 Adrenergic Receptor, Rat | 46 | 0.49 | Binding ≤ 1μM |
| ADRB3_RAT | P26255 | Beta-3 Adrenergic Receptor, Rat | 46 | 0.49 | Binding ≤ 1μM |
| ADCY1_HUMAN | Q08828 | Brain Adenylate Cyclase 1, Human | 160 | 0.45 | Binding ≤ 1μM |
| DRD1_RAT | P18901 | Dopamine D1 Receptor, Rat | 645 | 0.41 | Binding ≤ 1μM |
| DRD2_MOUSE | P61168 | Dopamine D2 Receptor, Mouse | 726 | 0.41 | Binding ≤ 1μM |
| DRD2_HUMAN | P14416 | Dopamine D2 Receptor, Human | 726 | 0.41 | Binding ≤ 1μM |
| DRD2_RAT | P61169 | Dopamine D2 Receptor, Rat | 645 | 0.41 | Binding ≤ 1μM |
| DRD3_RAT | P19020 | Dopamine D3 Receptor, Rat | 645 | 0.41 | Binding ≤ 1μM |
| DRD4_RAT | P30729 | Dopamine D4 Receptor, Rat | 645 | 0.41 | Binding ≤ 1μM |
| DRD5_RAT | P25115 | Dopamine D5 Receptor, Rat | 645 | 0.41 | Binding ≤ 1μM |
| SC6A3_MOUSE | Q61327 | Dopamine Transporter, Mouse | 42 | 0.49 | Binding ≤ 1μM |
| HRH1_RAT | P31390 | Histamine H1 Receptor, Rat | 0.1 | 0.67 | Binding ≤ 1μM |
| HRH2_RAT | P25102 | Histamine H2 Receptor, Rat | 30 | 0.50 | Binding ≤ 1μM |
| HRH3_RAT | Q9QYN8 | Histamine H3 Receptor, Rat | 30 | 0.50 | Binding ≤ 1μM |
| HRH4_RAT | Q91ZY1 | Histamine H4 Receptor, Rat | 30 | 0.50 | Binding ≤ 1μM |
| Z104303 | Z104303 | Muscarinic Acetylcholine Receptor | 269 | 0.44 | Binding ≤ 1μM |
| ACM5_RAT | P08911 | Muscarinic Acetylcholine Receptor M5, Rat | 300 | 0.43 | Binding ≤ 1μM |
| SC6A2_HUMAN | P23975 | Norepinephrine Transporter, Human | 16 | 0.52 | Binding ≤ 1μM |
| Q9WTR4_RAT | Q9WTR4 | Norepinephrine Transporter, Rat | 12 | 0.53 | Binding ≤ 1μM |
| SC6A2_MOUSE | O55192 | Norepinephrine Transporter, Mouse | 12 | 0.53 | Binding ≤ 1μM |
| Z50597 | Z50597 | Rattus Norvegicus | 12 | 0.53 | Binding ≤ 1μM |
| 5HT1A_RAT | P19327 | Serotonin 1a (5-HT1a) Receptor, Rat | 44 | 0.49 | Binding ≤ 1μM |
| 5HT1B_RAT | P28564 | Serotonin 1b (5-HT1b) Receptor, Rat | 44 | 0.49 | Binding ≤ 1μM |
| 5HT1D_RAT | P28565 | Serotonin 1d (5-HT1d) Receptor, Rat | 44 | 0.49 | Binding ≤ 1μM |
| 5HT1F_RAT | P30940 | Serotonin 1f (5-HT1f) Receptor, Rat | 44 | 0.49 | Binding ≤ 1μM |
| 5HT2A_RAT | P14842 | Serotonin 2a (5-HT2a) Receptor, Rat | 23 | 0.51 | Binding ≤ 1μM |
| 5HT2A_HUMAN | P28223 | Serotonin 2a (5-HT2a) Receptor, Human | 160 | 0.45 | Binding ≤ 1μM |
| 5HT2B_RAT | P30994 | Serotonin 2b (5-HT2b) Receptor, Rat | 23 | 0.51 | Binding ≤ 1μM |
| 5HT2C_RAT | P08909 | Serotonin 2c (5-HT2c) Receptor, Rat | 23 | 0.51 | Binding ≤ 1μM |
| 5HT2C_MOUSE | P34968 | Serotonin 2c (5-HT2c) Receptor, Mouse | 160 | 0.45 | Binding ≤ 1μM |
| 5HT2C_HUMAN | P28335 | Serotonin 2c (5-HT2c) Receptor, Human | 160 | 0.45 | Binding ≤ 1μM |
| 5HT4R_RAT | Q62758 | Serotonin 4 (5-HT4) Receptor, Rat | 44 | 0.49 | Binding ≤ 1μM |
| 5HT5A_RAT | P35364 | Serotonin 5a (5-HT5a) Receptor, Rat | 44 | 0.49 | Binding ≤ 1μM |
| 5HT5B_RAT | P35365 | Serotonin 5b (5-HT5b) Receptor, Rat | 44 | 0.49 | Binding ≤ 1μM |
| 5HT6R_RAT | P31388 | Serotonin 6 (5-HT6) Receptor, Rat | 44 | 0.49 | Binding ≤ 1μM |
| 5HT7R_RAT | P32305 | Serotonin 7 (5-HT7) Receptor, Rat | 44 | 0.49 | Binding ≤ 1μM |
| SC6A4_MOUSE | Q60857 | Serotonin Transporter, Mouse | 5 | 0.55 | Binding ≤ 1μM |
| SC6A4_RAT | P31652 | Serotonin Transporter, Rat | 41.8 | 0.49 | Binding ≤ 1μM |
| SC6A4_HUMAN | P31645 | Serotonin Transporter, Human | 0.77 | 0.61 | Binding ≤ 1μM |
| AA3R_HUMAN | P33765 | Adenosine A3 Receptor, Human | 4.4 | 0.56 | Binding ≤ 10μM |
| ADCY2_HUMAN | Q08462 | Adenylate Cyclase Type II, Human | 160 | 0.45 | Binding ≤ 10μM |
| ADCY8_HUMAN | P40145 | Adenylate Cyclase Type VIII, Human | 160 | 0.45 | Binding ≤ 10μM |
| Z104304 | Z104304 | Adrenergic Receptor Alpha-1 | 160 | 0.45 | Binding ≤ 10μM |
| ADA1A_RAT | P43140 | Alpha-1a Adrenergic Receptor, Rat | 1.7 | 0.58 | Binding ≤ 10μM |
| ADA1B_RAT | P15823 | Alpha-1b Adrenergic Receptor, Rat | 46 | 0.49 | Binding ≤ 10μM |
| ADA1D_RAT | P23944 | Alpha-1d Adrenergic Receptor, Rat | 46 | 0.49 | Binding ≤ 10μM |
| ADA2A_RAT | P22909 | Alpha-2a Adrenergic Receptor, Rat | 255 | 0.44 | Binding ≤ 10μM |
| ADA2B_RAT | P19328 | Alpha-2b Adrenergic Receptor, Rat | 255 | 0.44 | Binding ≤ 10μM |
| ADA2C_RAT | P22086 | Alpha-2c Adrenergic Receptor, Rat | 255 | 0.44 | Binding ≤ 10μM |
| ADRB1_RAT | P18090 | Beta-1 Adrenergic Receptor, Rat | 46 | 0.49 | Binding ≤ 10μM |
| ADRB2_RAT | P10608 | Beta-2 Adrenergic Receptor, Rat | 46 | 0.49 | Binding ≤ 10μM |
| ADRB3_RAT | P26255 | Beta-3 Adrenergic Receptor, Rat | 46 | 0.49 | Binding ≤ 10μM |
| ADCY1_HUMAN | Q08828 | Brain Adenylate Cyclase 1, Human | 160 | 0.45 | Binding ≤ 10μM |
| DRD1_RAT | P18901 | Dopamine D1 Receptor, Rat | 645 | 0.41 | Binding ≤ 10μM |
| DRD2_RAT | P61169 | Dopamine D2 Receptor, Rat | 645 | 0.41 | Binding ≤ 10μM |
| DRD2_MOUSE | P61168 | Dopamine D2 Receptor, Mouse | 726 | 0.41 | Binding ≤ 10μM |
| DRD2_HUMAN | P14416 | Dopamine D2 Receptor, Human | 726 | 0.41 | Binding ≤ 10μM |
| DRD3_RAT | P19020 | Dopamine D3 Receptor, Rat | 645 | 0.41 | Binding ≤ 10μM |
| DRD4_RAT | P30729 | Dopamine D4 Receptor, Rat | 645 | 0.41 | Binding ≤ 10μM |
| DRD5_RAT | P25115 | Dopamine D5 Receptor, Rat | 645 | 0.41 | Binding ≤ 10μM |
| SC6A3_MOUSE | Q61327 | Dopamine Transporter, Mouse | 42 | 0.49 | Binding ≤ 10μM |
| KCNH2_HUMAN | Q12809 | HERG, Human | 3388.44156 | 0.36 | Binding ≤ 10μM |
| HRH1_RAT | P31390 | Histamine H1 Receptor, Rat | 0.1 | 0.67 | Binding ≤ 10μM |
| HRH2_RAT | P25102 | Histamine H2 Receptor, Rat | 30 | 0.50 | Binding ≤ 10μM |
| HRH3_RAT | Q9QYN8 | Histamine H3 Receptor, Rat | 30 | 0.50 | Binding ≤ 10μM |
| HRH4_RAT | Q91ZY1 | Histamine H4 Receptor, Rat | 30 | 0.50 | Binding ≤ 10μM |
| Z104303 | Z104303 | Muscarinic Acetylcholine Receptor | 269 | 0.44 | Binding ≤ 10μM |
| ACM5_RAT | P08911 | Muscarinic Acetylcholine Receptor M5, Rat | 300 | 0.43 | Binding ≤ 10μM |
| SC6A2_HUMAN | P23975 | Norepinephrine Transporter, Human | 16 | 0.52 | Binding ≤ 10μM |
| SC6A2_MOUSE | O55192 | Norepinephrine Transporter, Mouse | 12 | 0.53 | Binding ≤ 10μM |
| Q9WTR4_RAT | Q9WTR4 | Norepinephrine Transporter, Rat | 12 | 0.53 | Binding ≤ 10μM |
| PRIO_HUMAN | P04156 | Prion Protein, Human | 10000 | 0.33 | Binding ≤ 10μM |
| Z50597 | Z50597 | Rattus Norvegicus | 12 | 0.53 | Binding ≤ 10μM |
| 5HT1A_RAT | P19327 | Serotonin 1a (5-HT1a) Receptor, Rat | 44 | 0.49 | Binding ≤ 10μM |
| 5HT1B_RAT | P28564 | Serotonin 1b (5-HT1b) Receptor, Rat | 44 | 0.49 | Binding ≤ 10μM |
| 5HT1D_RAT | P28565 | Serotonin 1d (5-HT1d) Receptor, Rat | 44 | 0.49 | Binding ≤ 10μM |
| 5HT1F_RAT | P30940 | Serotonin 1f (5-HT1f) Receptor, Rat | 44 | 0.49 | Binding ≤ 10μM |
| 5HT2A_RAT | P14842 | Serotonin 2a (5-HT2a) Receptor, Rat | 23 | 0.51 | Binding ≤ 10μM |
| 5HT2A_HUMAN | P28223 | Serotonin 2a (5-HT2a) Receptor, Human | 160 | 0.45 | Binding ≤ 10μM |
| 5HT2B_RAT | P30994 | Serotonin 2b (5-HT2b) Receptor, Rat | 23 | 0.51 | Binding ≤ 10μM |
| 5HT2C_RAT | P08909 | Serotonin 2c (5-HT2c) Receptor, Rat | 23 | 0.51 | Binding ≤ 10μM |
| 5HT2C_MOUSE | P34968 | Serotonin 2c (5-HT2c) Receptor, Mouse | 160 | 0.45 | Binding ≤ 10μM |
| 5HT2C_HUMAN | P28335 | Serotonin 2c (5-HT2c) Receptor, Human | 160 | 0.45 | Binding ≤ 10μM |
| 5HT4R_RAT | Q62758 | Serotonin 4 (5-HT4) Receptor, Rat | 44 | 0.49 | Binding ≤ 10μM |
| 5HT5A_RAT | P35364 | Serotonin 5a (5-HT5a) Receptor, Rat | 44 | 0.49 | Binding ≤ 10μM |
| 5HT5B_RAT | P35365 | Serotonin 5b (5-HT5b) Receptor, Rat | 44 | 0.49 | Binding ≤ 10μM |
| 5HT6R_RAT | P31388 | Serotonin 6 (5-HT6) Receptor, Rat | 44 | 0.49 | Binding ≤ 10μM |
| 5HT7R_RAT | P32305 | Serotonin 7 (5-HT7) Receptor, Rat | 44 | 0.49 | Binding ≤ 10μM |
| SC6A4_HUMAN | P31645 | Serotonin Transporter, Human | 0.77 | 0.61 | Binding ≤ 10μM |
| SC6A4_MOUSE | Q60857 | Serotonin Transporter, Mouse | 5 | 0.55 | Binding ≤ 10μM |
| SC6A4_RAT | P31652 | Serotonin Transporter, Rat | 41.8 | 0.49 | Binding ≤ 10μM |
| SCN1A_HUMAN | P35498 | Sodium Channel Protein Type I Alpha Subunit, Human | 3600 | 0.36 | Binding ≤ 10μM |
| SCN2A_HUMAN | Q99250 | Sodium Channel Protein Type II Alpha Subunit, Human | 3600 | 0.36 | Binding ≤ 10μM |
| SCN3A_HUMAN | Q9NY46 | Sodium Channel Protein Type III Alpha Subunit, Human | 3600 | 0.36 | Binding ≤ 10μM |
| SCN8A_HUMAN | Q9UQD0 | Sodium Channel Protein Type VIII Alpha Subunit, Human | 3600 | 0.36 | Binding ≤ 10μM |
| KCNH2_HUMAN | Q12809 | HERG, Human | 3400 | 0.36 | Functional ≤ 10μM |
| HRH2_HUMAN | P25021 | Histamine H2 Receptor, Human | 1900 | 0.38 | Functional ≤ 10μM |
| Z50594 | Z50594 | Mus Musculus | 1300 | 0.39 | Functional ≤ 10μM |
| Q9WTR4_RAT | Q9WTR4 | Norepinephrine Transporter, Rat | 1300 | 0.39 | Functional ≤ 10μM |
| Z50425 | Z50425 | Plasmodium Falciparum | 1258.92541 | 0.39 | Functional ≤ 10μM |
| Z50597 | Z50597 | Rattus Norvegicus | 105 | 0.47 | Functional ≤ 10μM |
| Z81138 | Z81138 | ScN2a (Scrapie-infected Neuroblastoma Cells) | 5000 | 0.35 | Functional ≤ 10μM |
| SC6A4_RAT | P31652 | Serotonin Transporter, Rat | 120 | 0.46 | Functional ≤ 10μM |
| Description | Species |
|---|---|
| Organic cation transport |
| Description | Species |
|---|---|
| Adenosine P1 receptors | |
| Adenylate cyclase activating pathway | |
| Adenylate cyclase inhibitory pathway | |
| Adrenaline signalling through Alpha-2 adrenergic receptor | |
| Adrenaline,noradrenaline inhibits insulin secretion | |
| Adrenoceptors | |
| CREB phosphorylation through the activation of Adenylate Cyclase | |
| Dopamine clearance from the synaptic cleft | |
| Dopamine receptors | |
| G alpha (12/13) signalling events | |
| G alpha (i) signalling events | |
| G alpha (q) signalling events | |
| G alpha (s) signalling events | |
| G alpha (z) signalling events | |
| Glucagon signaling in metabolic regulation | |
| Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | |
| Histamine receptors | |
| Interaction between L1 and Ankyrins | |
| Muscarinic acetylcholine receptors | |
| Na+/Cl- dependent neurotransmitter transporters | |
| NCAM1 interactions | |
| PKA activation | |
| PKA activation in glucagon signalling | |
| Serotonin receptors | |
| Vasopressin regulates renal water homeostasis via Aquaporins | |
| Voltage gated Potassium channels |
