UCSF

EvoBlocks

Binding 10μM Binding 1μM Functional 10μM ADME/T 10μM

Binding 10μM Targets with Highest Number of Available Compounds (103 in total)

Name (Uniprot) Swissprot ChEMBL Description Size Browse Download (Annotations)
I23O1_HUMAN P14902 CHEMBL4685 Indoleamine 2,3-dioxygenase 9 Annotations Catalogs SMILES SDF Mol2 Flexibase
AOFB_HUMAN P27338 CHEMBL2039 Monoamine oxidase B 4 Annotations Catalogs SMILES SDF Mol2 Flexibase
ABL1_HUMAN P00519 CHEMBL1862 Tyrosine-protein kinase ABL 3 Annotations Catalogs SMILES SDF Mol2 Flexibase
ADA2A_BOVIN Q28838 CHEMBL4744 Alpha-2a adrenergic receptor 3 Annotations Catalogs SMILES SDF Mol2 Flexibase
MK14_HUMAN Q16539 CHEMBL260 MAP kinase p38 alpha 3 Annotations Catalogs SMILES SDF Mol2 Flexibase
NOS1_HUMAN P29475 CHEMBL3568 Nitric-oxide synthase, brain 3 Annotations Catalogs SMILES SDF Mol2 Flexibase
AA1R_HUMAN P30542 CHEMBL226 Adenosine A1 receptor 2 Annotations Catalogs SMILES SDF Mol2 Flexibase
AA2AR_HUMAN P29274 CHEMBL251 Adenosine A2a receptor 2 Annotations Catalogs SMILES SDF Mol2 Flexibase
ABL2_HUMAN P42684 CHEMBL4014 Tyrosine-protein kinase ABL2 2 Annotations Catalogs SMILES SDF Mol2 Flexibase
ADA1A_BOVIN P18130 CHEMBL4892 Alpha-1a adrenergic receptor 2 Annotations Catalogs SMILES SDF Mol2 Flexibase
EGFR_HUMAN P00533 CHEMBL203 Epidermal growth factor receptor erbB1 2 Annotations Catalogs SMILES SDF Mol2 Flexibase
GLR_HUMAN P47871 CHEMBL1985 Glucagon receptor 2 Annotations Catalogs SMILES SDF Mol2 Flexibase
KPCA_HUMAN P17252 CHEMBL299 Protein kinase C alpha 2 Annotations Catalogs SMILES SDF Mol2 Flexibase
KPCB_HUMAN P05771 CHEMBL3045 Protein kinase C beta 2 Annotations Catalogs SMILES SDF Mol2 Flexibase
LCK_HUMAN P06239 CHEMBL258 Tyrosine-protein kinase LCK 2 Annotations Catalogs SMILES SDF Mol2 Flexibase
LOX5_HUMAN P09917 CHEMBL215 Arachidonate 5-lipoxygenase 2 Annotations Catalogs SMILES SDF Mol2 Flexibase
LOX5_MOUSE P48999 CHEMBL5211 Arachidonate 5-lipoxygenase 2 Annotations Catalogs SMILES SDF Mol2 Flexibase
MK11_HUMAN Q15759 CHEMBL3961 MAP kinase p38 beta 2 Annotations Catalogs SMILES SDF Mol2 Flexibase
NOS2_HUMAN P35228 CHEMBL4481 Nitric oxide synthase, inducible 2 Annotations Catalogs SMILES SDF Mol2 Flexibase
OXDA_HUMAN P14920 CHEMBL5485 D-amino-acid oxidase 2 Annotations Catalogs SMILES SDF Mol2 Flexibase
PGH2_MOUSE Q05769 CHEMBL4321 Cyclooxygenase-2 2 Annotations Catalogs SMILES SDF Mol2 Flexibase
5HT3A_HUMAN P46098 CHEMBL1899 Serotonin 3a (5-HT3a) receptor 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
5HT3B_HUMAN O95264 CHEMBL3895 Serotonin 3b (5-HT3b) receptor 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
5HT3C_HUMAN Q8WXA8 CHEMBL4795 Serotonin 3c (5-HT3c) receptor 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
5HT3D_HUMAN Q70Z44 CHEMBL4673 Serotonin 3d (5-HT3d) receptor 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
5HT3E_HUMAN A5X5Y0 CHEMBL3812 Serotonin 3e (5-HT3e) receptor 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
ANKK1_HUMAN Q8NFD2 CHEMBL5547 Ankyrin repeat and protein kinase domain-containing protein 1 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
BLK_HUMAN P51451 CHEMBL2250 Tyrosine-protein kinase BLK 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
BRAF_HUMAN P15056 CHEMBL5145 Serine/threonine-protein kinase B-raf 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
CDK19_HUMAN Q9BWU1 CHEMBL6002 Cell division cycle 2-like protein kinase 6 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
CDK5_HUMAN Q00535 CHEMBL4036 Cyclin-dependent kinase 5 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
CDK8_HUMAN P49336 CHEMBL5719 Cell division protein kinase 8 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
CSF1R_HUMAN P07333 CHEMBL1844 Macrophage colony stimulating factor receptor 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
CTRO_HUMAN O14578 CHEMBL5579 Citron Rho-interacting kinase 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
DDR1_HUMAN Q08345 CHEMBL5319 Epithelial discoidin domain-containing receptor 1 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
DDR2_HUMAN Q16832 CHEMBL5122 Discoidin domain-containing receptor 2 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
EPHA1_HUMAN P21709 CHEMBL5810 Ephrin type-A receptor 1 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
EPHA2_HUMAN P29317 CHEMBL2068 Ephrin type-A receptor 2 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
EPHA3_HUMAN P29320 CHEMBL4954 Ephrin type-A receptor 3 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
EPHA4_HUMAN P54764 CHEMBL3988 Ephrin type-A receptor 4 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
EPHA5_HUMAN P54756 CHEMBL3987 Ephrin type-A receptor 5 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
EPHA6_HUMAN Q9UF33 CHEMBL4526 Ephrin type-A receptor 6 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
EPHA7_HUMAN Q15375 CHEMBL4602 Ephrin type-A receptor 7 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
EPHA8_HUMAN P29322 CHEMBL4134 Ephrin type-A receptor 8 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
EPHB1_HUMAN P54762 CHEMBL5072 Ephrin type-B receptor 1 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
EPHB2_HUMAN P29323 CHEMBL3290 Ephrin type-B receptor 2 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
F16P1_HUMAN P09467 CHEMBL3975 Fructose-1,6-bisphosphatase 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
FAK1_HUMAN Q05397 CHEMBL2695 Focal adhesion kinase 1 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
FAK2_HUMAN Q14289 CHEMBL5469 Protein tyrosine kinase 2 beta 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
FGFR1_HUMAN P11362 CHEMBL3650 Fibroblast growth factor receptor 1 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
FLT3_HUMAN P36888 CHEMBL1974 Tyrosine-protein kinase receptor FLT3 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
FRK_HUMAN P42685 CHEMBL4223 Tyrosine-protein kinase FRK 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
HSPB1_HUMAN P04792 CHEMBL5976 Heat shock protein beta-1 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
KIT_HUMAN P10721 CHEMBL1936 Stem cell growth factor receptor 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
KMO_RAT O88867 CHEMBL3457 Kynurenine 3-monooxygenase 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
LTK_HUMAN P29376 CHEMBL5627 Leukocyte tyrosine kinase receptor 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
LYN_HUMAN P07948 CHEMBL3905 Tyrosine-protein kinase Lyn 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
M4K4_HUMAN O95819 CHEMBL6166 Mitogen-activated protein kinase kinase kinase kinase 4 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
MERTK_HUMAN Q12866 CHEMBL5331 Proto-oncogene tyrosine-protein kinase MER 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
MK08_HUMAN P45983 CHEMBL2276 c-Jun N-terminal kinase 1 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
MK09_HUMAN P45984 CHEMBL4179 c-Jun N-terminal kinase 2 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
MK10_HUMAN P53779 CHEMBL2637 c-Jun N-terminal kinase 3 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
MK12_HUMAN P53778 CHEMBL4674 MAP kinase p38 gamma 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
MK13_HUMAN O15264 CHEMBL2939 MAP kinase p38 delta 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
MK14_MOUSE P47811 CHEMBL2336 MAP kinase p38 alpha 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
MK15_HUMAN Q8TD08 CHEMBL5198 Mitogen-activated protein kinase 15 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
MKNK1_HUMAN Q9BUB5 CHEMBL4718 MAP kinase-interacting serine/threonine-protein kinase MNK1 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
MKNK2_HUMAN Q9HBH9 CHEMBL4204 MAP kinase signal-integrating kinase 2 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
MLTK_HUMAN Q9NYL2 CHEMBL3886 Mixed lineage kinase 7 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
MRCKA_HUMAN Q5VT25 CHEMBL4516 Serine/threonine-protein kinase MRCK-A 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
MRCKB_HUMAN Q9Y5S2 CHEMBL5052 Serine/threonine-protein kinase MRCK beta 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
MRCKG_HUMAN Q6DT37 CHEMBL5615 Serine/threonine-protein kinase MRCK gamma 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
MUSK_HUMAN O15146 CHEMBL5684 Muscle, skeletal receptor tyrosine protein kinase 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
NLK_HUMAN Q9UBE8 CHEMBL5364 Serine/threonine protein kinase NLK 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
NOS2_MOUSE P29477 CHEMBL3464 Nitric oxide synthase, inducible 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
NOS3_HUMAN P29474 CHEMBL4803 Nitric-oxide synthase, endothelial 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
NTRK1_HUMAN P04629 CHEMBL2815 Nerve growth factor receptor Trk-A 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
NTRK2_HUMAN Q16620 CHEMBL4898 Neurotrophic tyrosine kinase receptor type 2 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
NTRK3_HUMAN Q16288 CHEMBL5608 NT-3 growth factor receptor 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
OXDA_RAT O35078 CHEMBL5756 D-amino-acid oxidase 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
P90584_PLAFA P90584 CHEMBL4090 Protein kinase Pfmrk 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
PGFRA_HUMAN P16234 CHEMBL2007 Platelet-derived growth factor receptor alpha 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
PGFRB_HUMAN P09619 CHEMBL1913 Platelet-derived growth factor receptor beta 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
PGH1_MOUSE P22437 CHEMBL2649 Cyclooxygenase-1 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
PLD1_HUMAN Q13393 CHEMBL2536 Phospholipase D1 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
PPBT_HUMAN P05186 CHEMBL5979 Alkaline phosphatase, tissue-nonspecific isozyme 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
RAF1_HUMAN P04049 CHEMBL1906 Serine/threonine-protein kinase RAF 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
RET_HUMAN P07949 CHEMBL2041 Tyrosine-protein kinase receptor RET 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
SC6A4_RAT P31652 CHEMBL313 Serotonin transporter 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
SGMR1_HUMAN Q99720 CHEMBL287 Sigma opioid receptor 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
SLK_HUMAN Q9H2G2 CHEMBL4202 Serine/threonine-protein kinase 2 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
SRC_HUMAN P12931 CHEMBL267 Tyrosine-protein kinase SRC 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
STK10_HUMAN O94804 CHEMBL3981 Serine/threonine-protein kinase 10 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
TIE1_HUMAN P35590 CHEMBL5274 Tyrosine-protein kinase receptor Tie-1 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
TIE2_HUMAN Q02763 CHEMBL4128 Tyrosine-protein kinase TIE-2 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
TNFA_HUMAN P01375 CHEMBL1825 TNF-alpha 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
TNIK_HUMAN Q9UKE5 CHEMBL4527 TRAF2- and NCK-interacting kinase 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
TRPA1_HUMAN O75762 CHEMBL6007 Transient receptor potential cation channel subfamily A member 1 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
TTK_HUMAN P33981 CHEMBL3983 Dual specificity protein kinase TTK 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
VGFR1_HUMAN P17948 CHEMBL1868 Vascular endothelial growth factor receptor 1 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
VGFR2_HUMAN P35968 CHEMBL279 Vascular endothelial growth factor receptor 2 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
VGFR3_HUMAN P35916 CHEMBL1955 Vascular endothelial growth factor receptor 3 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
YES_HUMAN P07947 CHEMBL2073 Tyrosine-protein kinase YES 1 Annotations Catalogs SMILES SDF Mol2 Flexibase