Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	4.14	7.55	-7.08	1	4	0	35	326.831	1	↓ MOL2 SDF SMILES Flexibase
Hi High (pH 8-9.5)	4.14	8.88	-23.43	2	4	1	36	327.839	1	↓ MOL2 SDF SMILES Flexibase
Mid Mid (pH 6-8)	4.14	11.23	-89.99	3	4	2	38	328.847	1	↓ MOL2 SDF SMILES Flexibase
Mid Mid (pH 6-8)	4.14	9.89	-42.06	2	4	1	36	327.839	1	↓ MOL2 SDF SMILES Flexibase
Lo Low (pH 4.5-6)	4.14	11.17	-19.71	4	4	0	39	329.855	1	↓ MOL2 SDF SMILES Flexibase

Vendor Notes

Note Type	Comments	Provided By
ALOGPS_SOLUBILITY	1.86e-01 g/l	DrugBank-approved
MP	184 - 186	Enamine Building Blocks
MP	184...186	Enamine Building Blocks
Target	5-HT Receptor	Selleck Chemicals
purity	9.500000000000000e+001	Enamine Building Blocks Enamine Building Blocks
Purity	>98%	Fluorochem
therap	antipsychotic	MicroSource Spectrum
Indications	antipsychotic, schizophrenia, bipolar disorder	KeyOrganics Bioactives
Therapy	Atypical neuroleptic agent which display greater affinity for the D4 dopamine receptors over D2 or D3	SMDC Iconix
PUBCHEM_PATENT_ID	EP0019157A1; EP0019172A1; EP0291888A2; EP0291888B1; EP0428754A1; EP0428754B1; EP0475160B1; EP0574406B1; EP0621901B1; EP0668912B1; EP0669128B1; EP0693280A3; EP0709086A3; EP0711547A1; EP0799012A1; EP0799012B1; EP0799013B1; EP0801527A1; EP0801646A1; EP080277	IBM Patent Data
Patent Database Links	EP1181933; EP1547650; EP1576985; EP1627639; EP1688137; EP1690858; EP1726952; EP1815854; EP1829534; EP1844769; EP1884243; EP1952802; EP1990639; US2002147336; US2004142904; US2004176595; US2004254182; US2005009870; US2005014786; US2005080087; US2006166965	ChEBI
UniProt Database Links	HRH4_HUMAN	ChEBI
PUBCHEM_SUBSTANCE_COMMENT	NCC_SAMPLE_SUPPLIER : Enamine; NCC_SUPPLIER_STRUCTURE_ID : 241392105	NIH Clinical Collection via PubChem
PUBCHEM_SUBSTANCE_COMMENT	SAMPLE_SUPPLIER: Enamine; SUPPLIER_STRUCTURE_ID: 241392105	NIH Clinical Collection via PubChem

Activity (Go SEA)

Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
5HT1A-4-E	Serotonin 1a (5-HT1a) Receptor (cluster #4 Of 4), Eukaryotic	Eukaryotes	2000	0.35	Binding ≤ 10μM
5HT1B-1-E	Serotonin 1b (5-HT1b) Receptor (cluster #1 Of 2), Eukaryotic	Eukaryotes	8700	0.31	Binding ≤ 10μM
5HT1D-2-E	Serotonin 1d (5-HT1d) Receptor (cluster #2 Of 2), Eukaryotic	Eukaryotes	8700	0.31	Binding ≤ 10μM
5HT1F-1-E	Serotonin 1f (5-HT1f) Receptor (cluster #1 Of 2), Eukaryotic	Eukaryotes	8700	0.31	Binding ≤ 10μM
5HT2A-1-E	Serotonin 2a (5-HT2a) Receptor (cluster #1 Of 3), Eukaryotic	Eukaryotes	3	0.52	Binding ≤ 10μM
5HT2B-1-E	Serotonin 2b (5-HT2b) Receptor (cluster #1 Of 4), Eukaryotic	Eukaryotes	28	0.46	Binding ≤ 10μM
5HT2C-1-E	Serotonin 2c (5-HT2c) Receptor (cluster #1 Of 3), Eukaryotic	Eukaryotes	28	0.46	Binding ≤ 10μM
5HT3A-1-E	Serotonin 3a (5-HT3a) Receptor (cluster #1 Of 5), Eukaryotic	Eukaryotes	53	0.44	Binding ≤ 10μM
5HT3B-2-E	Serotonin 3b (5-HT3b) Receptor (cluster #2 Of 4), Eukaryotic	Eukaryotes	53	0.44	Binding ≤ 10μM
5HT5A-1-E	Serotonin 5a (5-HT5a) Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	1000	0.37	Binding ≤ 10μM
5HT6R-1-E	Serotonin 6 (5-HT6) Receptor (cluster #1 Of 2), Eukaryotic	Eukaryotes	10	0.49	Binding ≤ 10μM
5HT7R-1-E	Serotonin 7 (5-HT7) Receptor (cluster #1 Of 3), Eukaryotic	Eukaryotes	9	0.49	Binding ≤ 10μM
AA3R-1-E	Adenosine Receptor A3 (cluster #1 Of 6), Eukaryotic	Eukaryotes	156	0.41	Binding ≤ 10μM
ACM1-3-E	Muscarinic Acetylcholine Receptor M1 (cluster #3 Of 5), Eukaryotic	Eukaryotes	9	0.49	Binding ≤ 10μM
ACM2-4-E	Muscarinic Acetylcholine Receptor M2 (cluster #4 Of 6), Eukaryotic	Eukaryotes	91	0.43	Binding ≤ 10μM
ACM3-1-E	Muscarinic Acetylcholine Receptor M3 (cluster #1 Of 5), Eukaryotic	Eukaryotes	34	0.45	Binding ≤ 10μM
ACM4-1-E	Muscarinic Acetylcholine Receptor M4 (cluster #1 Of 6), Eukaryotic	Eukaryotes	91	0.43	Binding ≤ 10μM
ACM5-2-E	Muscarinic Acetylcholine Receptor M5 (cluster #2 Of 4), Eukaryotic	Eukaryotes	34	0.45	Binding ≤ 10μM
ADA1A-1-E	Alpha-1a Adrenergic Receptor (cluster #1 Of 3), Eukaryotic	Eukaryotes	4	0.51	Binding ≤ 10μM
ADA1B-1-E	Alpha-1b Adrenergic Receptor (cluster #1 Of 4), Eukaryotic	Eukaryotes	4	0.51	Binding ≤ 10μM
ADA1D-1-E	Alpha-1d Adrenergic Receptor (cluster #1 Of 3), Eukaryotic	Eukaryotes	4	0.51	Binding ≤ 10μM
ADA2A-1-E	Alpha-2a Adrenergic Receptor (cluster #1 Of 4), Eukaryotic	Eukaryotes	58	0.44	Binding ≤ 10μM
ADA2B-1-E	Alpha-2b Adrenergic Receptor (cluster #1 Of 4), Eukaryotic	Eukaryotes	58	0.44	Binding ≤ 10μM
ADA2C-1-E	Alpha-2c Adrenergic Receptor (cluster #1 Of 4), Eukaryotic	Eukaryotes	58	0.44	Binding ≤ 10μM
DRD1-2-E	Dopamine D1 Receptor (cluster #2 Of 4), Eukaryotic	Eukaryotes	8000	0.31	Binding ≤ 10μM
DRD3-1-E	Dopamine D3 Receptor (cluster #1 Of 2), Eukaryotic	Eukaryotes	960	0.37	Binding ≤ 10μM
DRD4-4-E	Dopamine D4 Receptor (cluster #4 Of 4), Eukaryotic	Eukaryotes	9	0.49	Binding ≤ 10μM
DRD5-1-E	Dopamine D5 Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	890	0.37	Binding ≤ 10μM
HRH1-1-E	Histamine H1 Receptor (cluster #1 Of 2), Eukaryotic	Eukaryotes	2	0.53	Binding ≤ 10μM
HRH2-1-E	Histamine H2 Receptor (cluster #1 Of 3), Eukaryotic	Eukaryotes	18	0.47	Binding ≤ 10μM
HRH3-1-E	Histamine H3 Receptor (cluster #1 Of 3), Eukaryotic	Eukaryotes	18	0.47	Binding ≤ 10μM
HRH4-1-E	Histamine H4 Receptor (cluster #1 Of 4), Eukaryotic	Eukaryotes	70	0.44	Binding ≤ 10μM
KCNH2-1-E	HERG (cluster #1 Of 5), Eukaryotic	Eukaryotes	6490	0.32	Binding ≤ 10μM
Q63380-1-E	Transporter (cluster #1 Of 1), Eukaryotic	Eukaryotes	390	0.39	Binding ≤ 10μM
Q9WTR4-1-E	Norepinephrine Transporter (cluster #1 Of 2), Eukaryotic	Eukaryotes	697	0.37	Binding ≤ 10μM
SC6A4-1-E	Serotonin Transporter (cluster #1 Of 4), Eukaryotic	Eukaryotes	3900	0.33	Binding ≤ 10μM
SGMR1-1-E	Sigma Opioid Receptor (cluster #1 Of 6), Eukaryotic	Eukaryotes	8500	0.31	Binding ≤ 10μM
HRH3-2-E	Histamine H3 Receptor (cluster #2 Of 2), Eukaryotic	Eukaryotes	631	0.38	Functional ≤ 10μM
KCNH2-1-E	HERG (cluster #1 Of 2), Eukaryotic	Eukaryotes	191	0.41	Functional ≤ 10μM
DRD2-15-E	Dopamine D2 Receptor (cluster #15 Of 24), Eukaryotic	Eukaryotes	290	0.40	Binding ≤ 10μM
Z104303-1-O	Muscarinic Acetylcholine Receptor (cluster #1 Of 7), Other	Other	51	0.44	Binding ≤ 10μM
Z104304-1-O	Adrenergic Receptor Alpha-1 (cluster #1 Of 3), Other	Other	9	0.49	Binding ≤ 10μM
Z102275-1-O	Hypothalamus (cluster #1 Of 1), Other	Other	10	0.49	Functional ≤ 10μM
Z50425-3-O	Plasmodium Falciparum (cluster #3 Of 22), Other	Other	7943	0.31	Functional ≤ 10μM

ChEMBL Target Annotations
Uniprot	Swissprot	Description	Affinity (nM)	LE (kcal/mol/atom)	Type
AA3R_HUMAN	P33765	Adenosine A3 Receptor, Human	156	0.41	Binding ≤ 1μM
Z104304	Z104304	Adrenergic Receptor Alpha-1	1.4	0.54	Binding ≤ 1μM
ADA1A_RAT	P43140	Alpha-1a Adrenergic Receptor, Rat	17	0.47	Binding ≤ 1μM
ADA1A_BOVIN	P18130	Alpha-1a Adrenergic Receptor, Bovin	160	0.41	Binding ≤ 1μM
ADA1A_HUMAN	P35348	Alpha-1a Adrenergic Receptor, Human	11	0.48	Binding ≤ 1μM
ADA1B_HUMAN	P35368	Alpha-1b Adrenergic Receptor, Human	11	0.48	Binding ≤ 1μM
ADA1B_RAT	P15823	Alpha-1b Adrenergic Receptor, Rat	17	0.47	Binding ≤ 1μM
ADA1D_HUMAN	P25100	Alpha-1d Adrenergic Receptor, Human	11	0.48	Binding ≤ 1μM
ADA1D_RAT	P23944	Alpha-1d Adrenergic Receptor, Rat	17	0.47	Binding ≤ 1μM
ADA2A_HUMAN	P08913	Alpha-2a Adrenergic Receptor, Human	160	0.41	Binding ≤ 1μM
ADA2A_RAT	P22909	Alpha-2a Adrenergic Receptor, Rat	128	0.42	Binding ≤ 1μM
ADA2B_RAT	P19328	Alpha-2b Adrenergic Receptor, Rat	128	0.42	Binding ≤ 1μM
ADA2B_HUMAN	P18089	Alpha-2b Adrenergic Receptor, Human	160	0.41	Binding ≤ 1μM
ADA2C_HUMAN	P18825	Alpha-2c Adrenergic Receptor, Human	160	0.41	Binding ≤ 1μM
ADA2C_RAT	P22086	Alpha-2c Adrenergic Receptor, Rat	128	0.42	Binding ≤ 1μM
DRD1_PIG	P50130	Dopamine D1 Receptor, Pig	420	0.39	Binding ≤ 1μM
DRD1_BOVIN	Q95136	Dopamine D1 Receptor, Bovin	180	0.41	Binding ≤ 1μM
DRD1_RAT	P18901	Dopamine D1 Receptor, Rat	114.815362	0.42	Binding ≤ 1μM
DRD1_HUMAN	P21728	Dopamine D1 Receptor, Human	132	0.42	Binding ≤ 1μM
DRD2_HUMAN	P14416	Dopamine D2 Receptor, Human	113	0.42	Binding ≤ 1μM
DRD2_BOVIN	P20288	Dopamine D2 Receptor, Bovin	140	0.42	Binding ≤ 1μM
DRD2_RAT	P61169	Dopamine D2 Receptor, Rat	1000	0.37	Binding ≤ 1μM
DRD2_MOUSE	P61168	Dopamine D2 Receptor, Mouse	290	0.40	Binding ≤ 1μM
DRD2_CHLAE	P52702	Dopamine D2 Receptor, Chlae	254	0.40	Binding ≤ 1μM
DRD3_RAT	P19020	Dopamine D3 Receptor, Rat	230	0.40	Binding ≤ 1μM
DRD3_HUMAN	P35462	Dopamine D3 Receptor, Human	180	0.41	Binding ≤ 1μM
DRD4_RAT	P30729	Dopamine D4 Receptor, Rat	247	0.40	Binding ≤ 1μM
DRD4_HUMAN	P21917	Dopamine D4 Receptor, Human	10	0.49	Binding ≤ 1μM
DRD5_RAT	P25115	Dopamine D5 Receptor, Rat	247	0.40	Binding ≤ 1μM
DRD5_HUMAN	P21918	Dopamine D5 Receptor, Human	180	0.41	Binding ≤ 1μM
KCNH2_HUMAN	Q12809	HERG, Human	190.546072	0.41	Binding ≤ 1μM
HRH1_RAT	P31390	Histamine H1 Receptor, Rat	14	0.48	Binding ≤ 1μM
HRH1_HUMAN	P35367	Histamine H1 Receptor, Human	1.1	0.55	Binding ≤ 1μM
HRH2_RAT	P25102	Histamine H2 Receptor, Rat	18	0.47	Binding ≤ 1μM
HRH3_RAT	Q9QYN8	Histamine H3 Receptor, Rat	18	0.47	Binding ≤ 1μM
HRH4_HUMAN	Q9H3N8	Histamine H4 Receptor, Human	11.9	0.48	Binding ≤ 1μM
HRH4_RAT	Q91ZY1	Histamine H4 Receptor, Rat	18	0.47	Binding ≤ 1μM
Z104303	Z104303	Muscarinic Acetylcholine Receptor	12	0.48	Binding ≤ 1μM
ACM1_HUMAN	P11229	Muscarinic Acetylcholine Receptor M1, Human	0.98	0.55	Binding ≤ 1μM
ACM1_RAT	P08482	Muscarinic Acetylcholine Receptor M1, Rat	2.1	0.53	Binding ≤ 1μM
ACM2_HUMAN	P08172	Muscarinic Acetylcholine Receptor M2, Human	34	0.45	Binding ≤ 1μM
ACM2_RAT	P10980	Muscarinic Acetylcholine Receptor M2, Rat	46	0.45	Binding ≤ 1μM
ACM3_HUMAN	P20309	Muscarinic Acetylcholine Receptor M3, Human	34	0.45	Binding ≤ 1μM
ACM3_RAT	P08483	Muscarinic Acetylcholine Receptor M3, Rat	91	0.43	Binding ≤ 1μM
ACM4_HUMAN	P08173	Muscarinic Acetylcholine Receptor M4, Human	34	0.45	Binding ≤ 1μM
ACM4_RAT	P08485	Muscarinic Acetylcholine Receptor M4, Rat	91	0.43	Binding ≤ 1μM
ACM5_HUMAN	P08912	Muscarinic Acetylcholine Receptor M5, Human	34	0.45	Binding ≤ 1μM
Q9WTR4_RAT	Q9WTR4	Norepinephrine Transporter, Rat	697	0.37	Binding ≤ 1μM
5HT1A_RAT	P19327	Serotonin 1a (5-HT1a) Receptor, Rat	111	0.42	Binding ≤ 1μM
5HT1A_HUMAN	P08908	Serotonin 1a (5-HT1a) Receptor, Human	140	0.42	Binding ≤ 1μM
5HT1B_RAT	P28564	Serotonin 1b (5-HT1b) Receptor, Rat	210	0.41	Binding ≤ 1μM
5HT1D_RAT	P28565	Serotonin 1d (5-HT1d) Receptor, Rat	210	0.41	Binding ≤ 1μM
5HT1F_RAT	P30940	Serotonin 1f (5-HT1f) Receptor, Rat	210	0.41	Binding ≤ 1μM
5HT2A_RAT	P14842	Serotonin 2a (5-HT2a) Receptor, Rat	1.8	0.53	Binding ≤ 1μM
5HT2A_HUMAN	P28223	Serotonin 2a (5-HT2a) Receptor, Human	12	0.48	Binding ≤ 1μM
5HT2A_BOVIN	Q75Z89	Serotonin 2a (5-HT2a) Receptor, Bovin	3	0.52	Binding ≤ 1μM
5HT2A_MOUSE	P35363	Serotonin 2a (5-HT2a) Receptor, Mouse	28	0.46	Binding ≤ 1μM
5HT2B_HUMAN	P41595	Serotonin 2b (5-HT2b) Receptor, Human	12	0.48	Binding ≤ 1μM
5HT2B_RAT	P30994	Serotonin 2b (5-HT2b) Receptor, Rat	1.8	0.53	Binding ≤ 1μM
5HT2B_MOUSE	Q02152	Serotonin 2b (5-HT2b) Receptor, Mouse	28	0.46	Binding ≤ 1μM
5HT2C_MOUSE	P34968	Serotonin 2c (5-HT2c) Receptor, Mouse	28	0.46	Binding ≤ 1μM
5HT2C_RAT	P08909	Serotonin 2c (5-HT2c) Receptor, Rat	1.8	0.53	Binding ≤ 1μM
5HT2C_HUMAN	P28335	Serotonin 2c (5-HT2c) Receptor, Human	10	0.49	Binding ≤ 1μM
5HT3A_MOUSE	P23979	Serotonin 3a (5-HT3a) Receptor, Mouse	32	0.46	Binding ≤ 1μM
5HT3A_RAT	P35563	Serotonin 3a (5-HT3a) Receptor, Rat	53	0.44	Binding ≤ 1μM
5HT3B_RAT	Q9JJ16	Serotonin 3b (5-HT3b) Receptor, Rat	53	0.44	Binding ≤ 1μM
5HT5A_HUMAN	P47898	Serotonin 5a (5-HT5a) Receptor, Human	1000	0.37	Binding ≤ 1μM
5HT6R_HUMAN	P50406	Serotonin 6 (5-HT6) Receptor, Human	10	0.49	Binding ≤ 1μM
5HT7R_HUMAN	P34969	Serotonin 7 (5-HT7) Receptor, Human	39.8107171	0.45	Binding ≤ 1μM
5HT7R_RAT	P32305	Serotonin 7 (5-HT7) Receptor, Rat	6.3	0.50	Binding ≤ 1μM
Q63380_RAT	Q63380	Transporter, Rat	390	0.39	Binding ≤ 1μM
AA3R_HUMAN	P33765	Adenosine A3 Receptor, Human	156	0.41	Binding ≤ 10μM
Z104304	Z104304	Adrenergic Receptor Alpha-1	1.4	0.54	Binding ≤ 10μM
ADA1A_RAT	P43140	Alpha-1a Adrenergic Receptor, Rat	17	0.47	Binding ≤ 10μM
ADA1A_BOVIN	P18130	Alpha-1a Adrenergic Receptor, Bovin	160	0.41	Binding ≤ 10μM
ADA1A_HUMAN	P35348	Alpha-1a Adrenergic Receptor, Human	11	0.48	Binding ≤ 10μM
ADA1B_HUMAN	P35368	Alpha-1b Adrenergic Receptor, Human	11	0.48	Binding ≤ 10μM
ADA1B_RAT	P15823	Alpha-1b Adrenergic Receptor, Rat	17	0.47	Binding ≤ 10μM
ADA1D_HUMAN	P25100	Alpha-1d Adrenergic Receptor, Human	11	0.48	Binding ≤ 10μM
ADA1D_RAT	P23944	Alpha-1d Adrenergic Receptor, Rat	17	0.47	Binding ≤ 10μM
ADA2A_HUMAN	P08913	Alpha-2a Adrenergic Receptor, Human	160	0.41	Binding ≤ 10μM
ADA2A_RAT	P22909	Alpha-2a Adrenergic Receptor, Rat	128	0.42	Binding ≤ 10μM
ADA2B_RAT	P19328	Alpha-2b Adrenergic Receptor, Rat	128	0.42	Binding ≤ 10μM
ADA2B_HUMAN	P18089	Alpha-2b Adrenergic Receptor, Human	160	0.41	Binding ≤ 10μM
ADA2C_HUMAN	P18825	Alpha-2c Adrenergic Receptor, Human	160	0.41	Binding ≤ 10μM
ADA2C_RAT	P22086	Alpha-2c Adrenergic Receptor, Rat	128	0.42	Binding ≤ 10μM
DRD1_RAT	P18901	Dopamine D1 Receptor, Rat	114.815362	0.42	Binding ≤ 10μM
DRD1_BOVIN	Q95136	Dopamine D1 Receptor, Bovin	180	0.41	Binding ≤ 10μM
DRD1_HUMAN	P21728	Dopamine D1 Receptor, Human	132	0.42	Binding ≤ 10μM
DRD1_PIG	P50130	Dopamine D1 Receptor, Pig	420	0.39	Binding ≤ 10μM
DRD2_HUMAN	P14416	Dopamine D2 Receptor, Human	113	0.42	Binding ≤ 10μM
DRD2_BOVIN	P20288	Dopamine D2 Receptor, Bovin	140	0.42	Binding ≤ 10μM
DRD2_RAT	P61169	Dopamine D2 Receptor, Rat	1000	0.37	Binding ≤ 10μM
DRD2_MOUSE	P61168	Dopamine D2 Receptor, Mouse	290	0.40	Binding ≤ 10μM
DRD2_CHLAE	P52702	Dopamine D2 Receptor, Chlae	254	0.40	Binding ≤ 10μM
DRD3_RAT	P19020	Dopamine D3 Receptor, Rat	230	0.40	Binding ≤ 10μM
DRD3_HUMAN	P35462	Dopamine D3 Receptor, Human	180	0.41	Binding ≤ 10μM
DRD4_RAT	P30729	Dopamine D4 Receptor, Rat	247	0.40	Binding ≤ 10μM
DRD4_HUMAN	P21917	Dopamine D4 Receptor, Human	10	0.49	Binding ≤ 10μM
DRD5_RAT	P25115	Dopamine D5 Receptor, Rat	247	0.40	Binding ≤ 10μM
DRD5_HUMAN	P21918	Dopamine D5 Receptor, Human	180	0.41	Binding ≤ 10μM
KCNH2_HUMAN	Q12809	HERG, Human	190.546072	0.41	Binding ≤ 10μM
HRH1_RAT	P31390	Histamine H1 Receptor, Rat	14	0.48	Binding ≤ 10μM
HRH1_HUMAN	P35367	Histamine H1 Receptor, Human	1.1	0.55	Binding ≤ 10μM
HRH2_RAT	P25102	Histamine H2 Receptor, Rat	18	0.47	Binding ≤ 10μM
HRH3_RAT	Q9QYN8	Histamine H3 Receptor, Rat	18	0.47	Binding ≤ 10μM
HRH4_HUMAN	Q9H3N8	Histamine H4 Receptor, Human	11.9	0.48	Binding ≤ 10μM
HRH4_RAT	Q91ZY1	Histamine H4 Receptor, Rat	18	0.47	Binding ≤ 10μM
Z104303	Z104303	Muscarinic Acetylcholine Receptor	12	0.48	Binding ≤ 10μM
ACM1_HUMAN	P11229	Muscarinic Acetylcholine Receptor M1, Human	0.98	0.55	Binding ≤ 10μM
ACM1_RAT	P08482	Muscarinic Acetylcholine Receptor M1, Rat	2.1	0.53	Binding ≤ 10μM
ACM2_HUMAN	P08172	Muscarinic Acetylcholine Receptor M2, Human	34	0.45	Binding ≤ 10μM
ACM2_RAT	P10980	Muscarinic Acetylcholine Receptor M2, Rat	46	0.45	Binding ≤ 10μM
ACM3_HUMAN	P20309	Muscarinic Acetylcholine Receptor M3, Human	34	0.45	Binding ≤ 10μM
ACM3_RAT	P08483	Muscarinic Acetylcholine Receptor M3, Rat	91	0.43	Binding ≤ 10μM
ACM4_RAT	P08485	Muscarinic Acetylcholine Receptor M4, Rat	91	0.43	Binding ≤ 10μM
ACM4_HUMAN	P08173	Muscarinic Acetylcholine Receptor M4, Human	34	0.45	Binding ≤ 10μM
ACM5_HUMAN	P08912	Muscarinic Acetylcholine Receptor M5, Human	34	0.45	Binding ≤ 10μM
Q9WTR4_RAT	Q9WTR4	Norepinephrine Transporter, Rat	697	0.37	Binding ≤ 10μM
5HT1A_MOUSE	Q64264	Serotonin 1a (5-HT1a) Receptor, Mouse	2000	0.35	Binding ≤ 10μM
5HT1A_RAT	P19327	Serotonin 1a (5-HT1a) Receptor, Rat	1010	0.36	Binding ≤ 10μM
5HT1A_HUMAN	P08908	Serotonin 1a (5-HT1a) Receptor, Human	140	0.42	Binding ≤ 10μM
5HT1B_RAT	P28564	Serotonin 1b (5-HT1b) Receptor, Rat	210	0.41	Binding ≤ 10μM
5HT1D_RAT	P28565	Serotonin 1d (5-HT1d) Receptor, Rat	210	0.41	Binding ≤ 10μM
5HT1F_RAT	P30940	Serotonin 1f (5-HT1f) Receptor, Rat	210	0.41	Binding ≤ 10μM
5HT2A_BOVIN	Q75Z89	Serotonin 2a (5-HT2a) Receptor, Bovin	3	0.52	Binding ≤ 10μM
5HT2A_MOUSE	P35363	Serotonin 2a (5-HT2a) Receptor, Mouse	28	0.46	Binding ≤ 10μM
5HT2A_RAT	P14842	Serotonin 2a (5-HT2a) Receptor, Rat	1.8	0.53	Binding ≤ 10μM
5HT2A_HUMAN	P28223	Serotonin 2a (5-HT2a) Receptor, Human	12	0.48	Binding ≤ 10μM
5HT2B_HUMAN	P41595	Serotonin 2b (5-HT2b) Receptor, Human	12	0.48	Binding ≤ 10μM
5HT2B_RAT	P30994	Serotonin 2b (5-HT2b) Receptor, Rat	1.8	0.53	Binding ≤ 10μM
5HT2B_MOUSE	Q02152	Serotonin 2b (5-HT2b) Receptor, Mouse	28	0.46	Binding ≤ 10μM
5HT2C_RAT	P08909	Serotonin 2c (5-HT2c) Receptor, Rat	1.8	0.53	Binding ≤ 10μM
5HT2C_HUMAN	P28335	Serotonin 2c (5-HT2c) Receptor, Human	10	0.49	Binding ≤ 10μM
5HT2C_MOUSE	P34968	Serotonin 2c (5-HT2c) Receptor, Mouse	28	0.46	Binding ≤ 10μM
5HT3A_RAT	P35563	Serotonin 3a (5-HT3a) Receptor, Rat	53	0.44	Binding ≤ 10μM
5HT3A_MOUSE	P23979	Serotonin 3a (5-HT3a) Receptor, Mouse	32	0.46	Binding ≤ 10μM
5HT3B_RAT	Q9JJ16	Serotonin 3b (5-HT3b) Receptor, Rat	53	0.44	Binding ≤ 10μM
5HT5A_HUMAN	P47898	Serotonin 5a (5-HT5a) Receptor, Human	1000	0.37	Binding ≤ 10μM
5HT6R_HUMAN	P50406	Serotonin 6 (5-HT6) Receptor, Human	10	0.49	Binding ≤ 10μM
5HT7R_RAT	P32305	Serotonin 7 (5-HT7) Receptor, Rat	6.3	0.50	Binding ≤ 10μM
5HT7R_HUMAN	P34969	Serotonin 7 (5-HT7) Receptor, Human	39.8107171	0.45	Binding ≤ 10μM
SC6A4_HUMAN	P31645	Serotonin Transporter, Human	3900	0.33	Binding ≤ 10μM
SGMR1_HUMAN	Q99720	Sigma Opioid Receptor, Human	8500	0.31	Binding ≤ 10μM
Q63380_RAT	Q63380	Transporter, Rat	390	0.39	Binding ≤ 10μM
KCNH2_HUMAN	Q12809	HERG, Human	191	0.41	Functional ≤ 10μM
HRH3_HUMAN	Q9Y5N1	Histamine H3 Receptor, Human	631	0.38	Functional ≤ 10μM
Z102275	Z102275	Hypothalamus	10	0.49	Functional ≤ 10μM
Z50425	Z50425	Plasmodium Falciparum	3981.07171	0.33	Functional ≤ 10μM

Reactome Annotations from Targets (via Uniprot)

Description	Species
Acetylcholine regulates insulin secretion	Rattus norvegicus (ACM3_RAT) Homo sapiens (ACM3_HUMAN)
Adenosine P1 receptors	Homo sapiens (AA3R_HUMAN)
Adrenaline signalling through Alpha-2 adrenergic receptor	Rattus norvegicus (ADA2B_RAT) Homo sapiens (ADA2A_HUMAN)
Adrenaline,noradrenaline inhibits insulin secretion	Homo sapiens (ADA2A_HUMAN) Rattus norvegicus (ADA2C_RAT)
Adrenoceptors	Rattus norvegicus (ADA2B_RAT) Homo sapiens (ADA2A_HUMAN)
Dopamine receptors	Homo sapiens (DRD2_HUMAN) Mus musculus (DRD2_MOUSE) Rattus norvegicus (DRD3_RAT) Bos taurus (DRD1_BOVIN)
G alpha (12/13) signalling events	Homo sapiens (ADA1D_HUMAN) Rattus norvegicus (ADA1A_RAT)
G alpha (i) signalling events	Homo sapiens (ACM2_HUMAN) Rattus norvegicus (ACM2_RAT) Mus musculus (DRD2_MOUSE)
G alpha (q) signalling events	Mus musculus (5HT2C_MOUSE) Bos taurus (5HT2A_BOVIN) Homo sapiens (ACM5_HUMAN) Rattus norvegicus (ACM1_RAT)
G alpha (s) signalling events	Homo sapiens (DRD1_HUMAN) Bos taurus (DRD1_BOVIN) Rattus norvegicus (5HT7R_RAT)
G alpha (z) signalling events	Rattus norvegicus (ADA2B_RAT) Homo sapiens (ADA2A_HUMAN)
Histamine receptors	Homo sapiens (HRH1_HUMAN) Rattus norvegicus (HRH3_RAT)
Muscarinic acetylcholine receptors	Homo sapiens (ACM2_HUMAN) Rattus norvegicus (ACM1_RAT)
Serotonin receptors	Homo sapiens (5HT1A_HUMAN) Mus musculus (5HT2C_MOUSE) Bos taurus (5HT2A_BOVIN) Rattus norvegicus (5HT2A_RAT)
Voltage gated Potassium channels	Homo sapiens (KCNH2_HUMAN)

Analogs ( Draw Identity 99% 90% 80% 70% )

Synonyms (146)
Vendors (32)
Annotations (30)
Representations (5)
Notes (14)
Targets (149)
Clustered (44)
Reactome (15)
Rings (0)
Analogs (5)