ZINC 12

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Chemik Building Blocks

Binding 10μM Binding 1μM Functional 10μM ADME/T 10μM

Binding 1μM Targets with Highest Number of Available Compounds (116 in total)

Name (Uniprot)	Swissprot	ChEMBL	Description	Size	Browse	Download (Annotations)
CAH2_HUMAN	P00918	CHEMBL205	Carbonic anhydrase II	8	Annotations Catalogs	SMILES SDF Mol2 Flexibase
5HT1A_RAT	P19327	CHEMBL273	Serotonin 1a (5-HT1a) receptor	6	Annotations Catalogs	SMILES SDF Mol2 Flexibase
5HT1B_RAT	P28564	CHEMBL3459	Serotonin 1b (5-HT1b) receptor	6	Annotations Catalogs	SMILES SDF Mol2 Flexibase
5HT1D_RAT	P28565	CHEMBL5450	Serotonin 1d (5-HT1d) receptor	6	Annotations Catalogs	SMILES SDF Mol2 Flexibase
5HT1F_RAT	P30940	CHEMBL4646	Serotonin 1f (5-HT1f) receptor	6	Annotations Catalogs	SMILES SDF Mol2 Flexibase
ACES_HUMAN	P22303	CHEMBL220	Acetylcholinesterase	6	Annotations Catalogs	SMILES SDF Mol2 Flexibase
NOS2_HUMAN	P35228	CHEMBL4481	Nitric oxide synthase, inducible	6	Annotations Catalogs	SMILES SDF Mol2 Flexibase
5HT1E_HUMAN	P28566	CHEMBL2182	Serotonin 1e (5-HT1e) receptor	5	Annotations Catalogs	SMILES SDF Mol2 Flexibase
5HT2A_RAT	P14842	CHEMBL322	Serotonin 2a (5-HT2a) receptor	5	Annotations Catalogs	SMILES SDF Mol2 Flexibase
5HT2B_RAT	P30994	CHEMBL323	Serotonin 2b (5-HT2b) receptor	5	Annotations Catalogs	SMILES SDF Mol2 Flexibase
5HT2C_RAT	P08909	CHEMBL324	Serotonin 2c (5-HT2c) receptor	5	Annotations Catalogs	SMILES SDF Mol2 Flexibase
CAH1_HUMAN	P00915	CHEMBL261	Carbonic anhydrase I	4	Annotations Catalogs	SMILES SDF Mol2 Flexibase
NOS3_HUMAN	P29474	CHEMBL4803	Nitric-oxide synthase, endothelial	4	Annotations Catalogs	SMILES SDF Mol2 Flexibase
Z104304	Z104304	CHEMBL1907610	Adrenergic receptor alpha-1	4	Annotations Catalogs	SMILES SDF Mol2 Flexibase
NOS1_HUMAN	P29475	CHEMBL3568	Nitric-oxide synthase, brain	3	Annotations Catalogs	SMILES SDF Mol2 Flexibase
5HT1D_HUMAN	P28221	CHEMBL1983	Serotonin 1d (5-HT1d) receptor	2	Annotations Catalogs	SMILES SDF Mol2 Flexibase
5HT5A_MOUSE	P30966	CHEMBL3597	Serotonin 5a (5-HT5a) receptor	2	Annotations Catalogs	SMILES SDF Mol2 Flexibase
5HT6R_HUMAN	P50406	CHEMBL3371	Serotonin 6 (5-HT6) receptor	2	Annotations Catalogs	SMILES SDF Mol2 Flexibase
ADRB1_RAT	P18090	CHEMBL3252	Beta-1 adrenergic receptor	2	Annotations Catalogs	SMILES SDF Mol2 Flexibase
CAH12_HUMAN	O43570	CHEMBL3242	Carbonic anhydrase XII	2	Annotations Catalogs	SMILES SDF Mol2 Flexibase
CAH14_HUMAN	Q9ULX7	CHEMBL3510	Carbonic anhydrase XIV	2	Annotations Catalogs	SMILES SDF Mol2 Flexibase
CAH4_HUMAN	P22748	CHEMBL3729	Carbonic anhydrase IV	2	Annotations Catalogs	SMILES SDF Mol2 Flexibase
CAH6_HUMAN	P23280	CHEMBL3025	Carbonic anhydrase VI	2	Annotations Catalogs	SMILES SDF Mol2 Flexibase
CAH7_HUMAN	P43166	CHEMBL2326	Carbonic anhydrase VII	2	Annotations Catalogs	SMILES SDF Mol2 Flexibase
CAH9_HUMAN	Q16790	CHEMBL3594	Carbonic anhydrase IX	2	Annotations Catalogs	SMILES SDF Mol2 Flexibase
FYN_HUMAN	P06241	CHEMBL1841	Tyrosine-protein kinase FYN	2	Annotations Catalogs	SMILES SDF Mol2 Flexibase
KCNH2_HUMAN	Q12809	CHEMBL240	HERG	2	Annotations Catalogs	SMILES SDF Mol2 Flexibase
LCK_HUMAN	P06239	CHEMBL258	Tyrosine-protein kinase LCK	2	Annotations Catalogs	SMILES SDF Mol2 Flexibase
NOS1_RAT	P29476	CHEMBL3048	Nitric-oxide synthase, brain	2	Annotations Catalogs	SMILES SDF Mol2 Flexibase
TOP1_HUMAN	P11387	CHEMBL1781	DNA topoisomerase I	2	Annotations Catalogs	SMILES SDF Mol2 Flexibase
5HT1A_HUMAN	P08908	CHEMBL214	Serotonin 1a (5-HT1a) receptor	1	Annotations Catalogs	SMILES SDF Mol2 Flexibase
5HT1B_HUMAN	P28222	CHEMBL1898	Serotonin 1b (5-HT1b) receptor	1	Annotations Catalogs	SMILES SDF Mol2 Flexibase
5HT2A_HUMAN	P28223	CHEMBL224	Serotonin 2a (5-HT2a) receptor	1	Annotations Catalogs	SMILES SDF Mol2 Flexibase
5HT2C_HUMAN	P28335	CHEMBL225	Serotonin 2c (5-HT2c) receptor	1	Annotations Catalogs	SMILES SDF Mol2 Flexibase
5HT3A_HUMAN	P46098	CHEMBL1899	Serotonin 3a (5-HT3a) receptor	1	Annotations Catalogs	SMILES SDF Mol2 Flexibase
5HT3A_RAT	P35563	CHEMBL2411	Serotonin 3a (5-HT3a) receptor	1	Annotations Catalogs	SMILES SDF Mol2 Flexibase
5HT3B_HUMAN	O95264	CHEMBL3895	Serotonin 3b (5-HT3b) receptor	1	Annotations Catalogs	SMILES SDF Mol2 Flexibase
5HT3B_RAT	Q9JJ16	CHEMBL3458	Serotonin 3b (5-HT3b) receptor	1	Annotations Catalogs	SMILES SDF Mol2 Flexibase
5HT3C_HUMAN	Q8WXA8	CHEMBL4795	Serotonin 3c (5-HT3c) receptor	1	Annotations Catalogs	SMILES SDF Mol2 Flexibase
5HT3D_HUMAN	Q70Z44	CHEMBL4673	Serotonin 3d (5-HT3d) receptor	1	Annotations Catalogs	SMILES SDF Mol2 Flexibase
5HT3E_HUMAN	A5X5Y0	CHEMBL3812	Serotonin 3e (5-HT3e) receptor	1	Annotations Catalogs	SMILES SDF Mol2 Flexibase
5HT4R_RAT	Q62758	CHEMBL4317	Serotonin 4 (5-HT4) receptor	1	Annotations Catalogs	SMILES SDF Mol2 Flexibase
5HT5A_HUMAN	P47898	CHEMBL3426	Serotonin 5a (5-HT5a) receptor	1	Annotations Catalogs	SMILES SDF Mol2 Flexibase
5HT5A_RAT	P35364	CHEMBL4655	Serotonin 5a (5-HT5a) receptor	1	Annotations Catalogs	SMILES SDF Mol2 Flexibase
5HT5B_RAT	P35365	CHEMBL2619	Serotonin 5b (5-HT5b) receptor	1	Annotations Catalogs	SMILES SDF Mol2 Flexibase
5HT6R_RAT	P31388	CHEMBL3372	Serotonin 6 (5-HT6) receptor	1	Annotations Catalogs	SMILES SDF Mol2 Flexibase
5HT7R_HUMAN	P34969	CHEMBL3155	Serotonin 7 (5-HT7) receptor	1	Annotations Catalogs	SMILES SDF Mol2 Flexibase
5HT7R_RAT	P32305	CHEMBL3223	Serotonin 7 (5-HT7) receptor	1	Annotations Catalogs	SMILES SDF Mol2 Flexibase
AA3R_HUMAN	P33765	CHEMBL256	Adenosine A3 receptor	1	Annotations Catalogs	SMILES SDF Mol2 Flexibase
ACH10_RAT	Q9JLB5	CHEMBL3461	Neuronal acetylcholine receptor protein alpha-10 subunit	1	Annotations Catalogs	SMILES SDF Mol2 Flexibase
ACHA3_RAT	P04757	CHEMBL3818	Neuronal acetylcholine receptor protein alpha-3 subunit	1	Annotations Catalogs	SMILES SDF Mol2 Flexibase
ACHA4_RAT	P09483	CHEMBL307	Neuronal acetylcholine receptor protein alpha-4 subunit	1	Annotations Catalogs	SMILES SDF Mol2 Flexibase
ADA2A_RAT	P22909	CHEMBL327	Alpha-2a adrenergic receptor	1	Annotations Catalogs	SMILES SDF Mol2 Flexibase
ADA2B_RAT	P19328	CHEMBL266	Alpha-2b adrenergic receptor	1	Annotations Catalogs	SMILES SDF Mol2 Flexibase
ADA2C_RAT	P22086	CHEMBL314	Alpha-2c adrenergic receptor	1	Annotations Catalogs	SMILES SDF Mol2 Flexibase
ADCY5_RAT	Q04400	CHEMBL2880	Adenylate cyclase type V	1	Annotations Catalogs	SMILES SDF Mol2 Flexibase
AK1C3_HUMAN	P42330	CHEMBL4681	Aldo-keto-reductase family 1 member C3	1	Annotations Catalogs	SMILES SDF Mol2 Flexibase
ANDR_HUMAN	P10275	CHEMBL1871	Androgen Receptor	1	Annotations Catalogs	SMILES SDF Mol2 Flexibase
AOFB_HUMAN	P27338	CHEMBL2039	Monoamine oxidase B	1	Annotations Catalogs	SMILES SDF Mol2 Flexibase
B5SU02_9CNID	B5SU02	CHEMBL1075028	Alpha carbonic anhydrase	1	Annotations Catalogs	SMILES SDF Mol2 Flexibase
C0IX24_9CNID	C0IX24	CHEMBL1649055	Carbonic anhydrase	1	Annotations Catalogs	SMILES SDF Mol2 Flexibase
CA2D1_MOUSE	O08532	CHEMBL4676	Voltage-gated calcium channel alpha2/delta subunit 1	1	Annotations Catalogs	SMILES SDF Mol2 Flexibase
CAH13_MOUSE	Q9D6N1	CHEMBL2186	Carbonic anhydrase XIII	1	Annotations Catalogs	SMILES SDF Mol2 Flexibase
CAH15_MOUSE	Q99N23	CHEMBL5973	Carbonic anhydrase 15	1	Annotations Catalogs	SMILES SDF Mol2 Flexibase
CAH2_BOVIN	P00921	CHEMBL2283	Carbonic anhydrase II	1	Annotations Catalogs	SMILES SDF Mol2 Flexibase
CAH3_HUMAN	P07451	CHEMBL2885	Carbonic anhydrase III	1	Annotations Catalogs	SMILES SDF Mol2 Flexibase
CAH4_BOVIN	Q95323	CHEMBL281	Carbonic anhydrase IV	1	Annotations Catalogs	SMILES SDF Mol2 Flexibase
CAH5A_HUMAN	P35218	CHEMBL4789	Carbonic anhydrase VA	1	Annotations Catalogs	SMILES SDF Mol2 Flexibase
CAH5B_HUMAN	Q9Y2D0	CHEMBL3969	Carbonic anhydrase VB	1	Annotations Catalogs	SMILES SDF Mol2 Flexibase
CNR1_RAT	P20272	CHEMBL3571	Cannabinoid CB1 receptor	1	Annotations Catalogs	SMILES SDF Mol2 Flexibase
CNR2_RAT	Q9QZN9	CHEMBL2470	Cannabinoid CB2 receptor	1	Annotations Catalogs	SMILES SDF Mol2 Flexibase
CP1B1_HUMAN	Q16678	CHEMBL4878	Cytochrome P450 1B1	1	Annotations Catalogs	SMILES SDF Mol2 Flexibase
DRD2_RAT	P61169	CHEMBL339	Dopamine D2 receptor	1	Annotations Catalogs	SMILES SDF Mol2 Flexibase
DYR_MYCTU	P0A546	CHEMBL6065	Dihydrofolate reductase	1	Annotations Catalogs	SMILES SDF Mol2 Flexibase
ERR1_HUMAN	P11474	CHEMBL3429	Estrogen-related receptor alpha	1	Annotations Catalogs	SMILES SDF Mol2 Flexibase
ERR2_HUMAN	O95718	CHEMBL3751	Estrogen-related receptor beta	1	Annotations Catalogs	SMILES SDF Mol2 Flexibase
ESR1_BOVIN	P49884	CHEMBL2930	Estrogen receptor alpha	1	Annotations Catalogs	SMILES SDF Mol2 Flexibase
ESR1_HUMAN	P03372	CHEMBL206	Estrogen receptor alpha	1	Annotations Catalogs	SMILES SDF Mol2 Flexibase
ESR1_MOUSE	P19785	CHEMBL3065	Estrogen receptor alpha	1	Annotations Catalogs	SMILES SDF Mol2 Flexibase
ESR1_RAT	P06211	CHEMBL2724	Estrogen receptor alpha	1	Annotations Catalogs	SMILES SDF Mol2 Flexibase
ESR2_HUMAN	Q92731	CHEMBL242	Estrogen receptor beta	1	Annotations Catalogs	SMILES SDF Mol2 Flexibase
ESR2_MOUSE	O08537	CHEMBL2995	Estrogen receptor beta	1	Annotations Catalogs	SMILES SDF Mol2 Flexibase
ESR2_RAT	Q62986	CHEMBL3021	Estrogen receptor beta	1	Annotations Catalogs	SMILES SDF Mol2 Flexibase
EST1_HUMAN	P23141	CHEMBL2265	Acyl coenzyme A:cholesterol acyltransferase	1	Annotations Catalogs	SMILES SDF Mol2 Flexibase
EST2_HUMAN	O00748	CHEMBL3180	Carboxylesterase 2	1	Annotations Catalogs	SMILES SDF Mol2 Flexibase
GPER_HUMAN	Q99527	CHEMBL5872	G-protein coupled estrogen receptor 1	1	Annotations Catalogs	SMILES SDF Mol2 Flexibase
GSK3B_HUMAN	P49841	CHEMBL262	Glycogen synthase kinase-3 beta	1	Annotations Catalogs	SMILES SDF Mol2 Flexibase
HCAR2_HUMAN	Q8TDS4	CHEMBL3785	Nicotinic acid receptor 1	1	Annotations Catalogs	SMILES SDF Mol2 Flexibase
HCAR2_MOUSE	Q9EP66	CHEMBL4420	HM74 nicotinic acid GPCR	1	Annotations Catalogs	SMILES SDF Mol2 Flexibase
HCAR2_RAT	Q80Z39	CHEMBL4731	HM74 nicotinic acid GPCR	1	Annotations Catalogs	SMILES SDF Mol2 Flexibase
MGLL_HUMAN	Q99685	CHEMBL4191	Monoglyceride lipase	1	Annotations Catalogs	SMILES SDF Mol2 Flexibase
O93874_CURLU	O93874	CHEMBL3925	17-beta-hydroxysteroid-dehydrogenase	1	Annotations Catalogs	SMILES SDF Mol2 Flexibase
P4HA1_RAT	P54001	CHEMBL3301	Prolyl 4-hydroxylase alpha-1 subunit	1	Annotations Catalogs	SMILES SDF Mol2 Flexibase
P4HTM_HUMAN	Q9NXG6	CHEMBL3047	Hypoxia-inducible factor prolyl 4-hydroxylase	1	Annotations Catalogs	SMILES SDF Mol2 Flexibase
PARP1_HUMAN	P09874	CHEMBL3105	Poly [ADP-ribose] polymerase-1	1	Annotations Catalogs	SMILES SDF Mol2 Flexibase
PNMT_HUMAN	P11086	CHEMBL4617	Phenylethanolamine N-methyltransferase	1	Annotations Catalogs	SMILES SDF Mol2 Flexibase
PTGDS_MOUSE	O09114	CHEMBL4334	Prostaglandin-H2 D-isomerase	1	Annotations Catalogs	SMILES SDF Mol2 Flexibase
Q3I4V7_CRYNV	Q3I4V7	CHEMBL1697676	Carbonic anhydrase 2	1	Annotations Catalogs	SMILES SDF Mol2 Flexibase
Q5AJ71_CANAL	Q5AJ71	CHEMBL5337	Carbonic anhydrase	1	Annotations Catalogs	SMILES SDF Mol2 Flexibase
Q79MP6_PSEAI	Q79MP6	CHEMBL1293244	Beta-lactamase	1	Annotations Catalogs	SMILES SDF Mol2 Flexibase
SHBG_HUMAN	P04278	CHEMBL3305	Testis-specific androgen-binding protein	1	Annotations Catalogs	SMILES SDF Mol2 Flexibase
TBA1A_PIG	P02550	CHEMBL3658	Tubulin alpha chain	1	Annotations Catalogs	SMILES SDF Mol2 Flexibase
TBA1A_RAT	P68370	CHEMBL4139	Tubulin alpha-1 chain	1	Annotations Catalogs	SMILES SDF Mol2 Flexibase
TBB1_HUMAN	Q9H4B7	CHEMBL1915	Tubulin beta-1 chain	1	Annotations Catalogs	SMILES SDF Mol2 Flexibase
TBB2B_BOVIN	Q6B856	CHEMBL3394	Tubulin beta chain	1	Annotations Catalogs	SMILES SDF Mol2 Flexibase
TBB3_HUMAN	Q13509	CHEMBL2597	Tubulin beta-3 chain	1	Annotations Catalogs	SMILES SDF Mol2 Flexibase
TBB4A_HUMAN	P04350	CHEMBL3838	Tubulin beta-4 chain	1	Annotations Catalogs	SMILES SDF Mol2 Flexibase
TBB4B_HUMAN	P68371	CHEMBL1848	Tubulin beta-2 chain	1	Annotations Catalogs	SMILES SDF Mol2 Flexibase
TBB5_HUMAN	P07437	CHEMBL5444	Tubulin beta-5 chain	1	Annotations Catalogs	SMILES SDF Mol2 Flexibase
TBB8_HUMAN	Q3ZCM7	CHEMBL4024	Tubulin beta-8 chain	1	Annotations Catalogs	SMILES SDF Mol2 Flexibase
TRPA1_HUMAN	O75762	CHEMBL6007	Transient receptor potential cation channel subfamily A member 1	1	Annotations Catalogs	SMILES SDF Mol2 Flexibase
TRY1_HUMAN	P07477	CHEMBL209	Trypsin I	1	Annotations Catalogs	SMILES SDF Mol2 Flexibase
TYRO_AGABI	O42713	CHEMBL3318	Tyrosinase	1	Annotations Catalogs	SMILES SDF Mol2 Flexibase
TYSY_MOUSE	P07607	CHEMBL3160	Thymidylate synthase	1	Annotations Catalogs	SMILES SDF Mol2 Flexibase
Y1284_MYCTU	P64797	CHEMBL5631	Uncharacterized protein Rv1284/MT1322	1	Annotations Catalogs	SMILES SDF Mol2 Flexibase
Z104301	Z104301	CHEMBL1907607	GABA-A receptor; anion channel	1	Annotations Catalogs	SMILES SDF Mol2 Flexibase